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The Informant Issue11.Pdf The Friedman Brain Institute is proud to present the 11th issue of the FBI Informant. The Informant is a triennial newsletter highlighting announcements and events for basic and clinical neuroscience at Mount Sinai. The purpose of riedman rain nstitute the Informant is to keep everyone abreast of all that is going on in and out of the F B I labs and clinics that comprise the Friedman Brain Institute, as well as acknowledge those individuals responsible for its success. In addition to sharing the information, our hope is that the Informant can be used as a tool to inspire, informant congratulate, and support one another. Announcements Dr. Rita Goldstein and Dr. Alia-Klein (Psychiatry) Co-Chief’s of NARC (Neuropsychoimaging of Addiction and Related Conditions) Research Program • We are pleased to announce that Dr. Goldstein has accepted the position of Director of the Friedman Brain Institute’s neuroimaging center, Brain Imaging Core (BIC). Dr. Goldstein is world-renowned for her neuroimaging and neuropsychological studies in drug addiction. We look forward to an exciting new era of neuroimaging at Mount Sinai. Please join us in congratulating Dr. Goldstein on her new role. • Nelly Alia-Klein, PhD is an invited panelist by the National Academies for the panel on Brain Disorders, Drugs, Psychopathy, and Violence: What are the Links? At the Institute of Medicine’s 2013 Annual Meeting entitled, The Science of Violence: Causation, Mitigation, and Prevention. • Congratulations to Anna B Konova, MA on receiving the Stony Brook University GSO Distinguished Travel Award, 2013. • Congratulations to Scott J. Moeller, PhD on receiving two travel awards this summer: one to attend the annual meeting of the College on Problems of Drug Dependence (CPDD) and one to attend the annual meeting of the American College of Neuropsychopharmacology (ACNP). • NARC is gearing up to launch its imaging protocol in the new state-of-the-art Translational and Molecular Imaging Institute within the Hess Center for Science and Medicine. Our subjects’ testing will be conducted in the KCC (neuropsychology including CANTAB tests, EEG/ERPs and Brain Computer Interface experiments, rTMS, clinical/ diagnostic interviews) and CSM (fMRI, PET-MRI). • Federico d'Oleire Uquillas, one of NARC's Clinical Research Coordinators, has been elected to the executive board for the Sinai Neuroscience Outreach Program (SNOP). • New group members include Rebecca Preston-Campbell, PhD who joined the laboratory as a Post- Doctoral Fellow in August. She received her PhD in Clinical Psychology from Hofstra University, with her clinical background strongly rooted in evidence-based treatment modalities, specifically cognitive behavior therapy and mindfulness based approaches. She received training at the New York State Psychiatric Institute within the Columbia University Medical Center studying sex differences in behaviors related to cocaine and alcohol use disorders in various groups of men and women, including current cocaine and/or alcohol users. Her research interests concentrate on factors involved in impaired self-regulatory behaviors that are often implicated in the development and maintenance of substance use and impulse control disorders. Recent Publications: • Volkow ND, Tomasi D, Wang GJ, Telang F, Fowler JS, Goldstein RZ, Alia-Klein N, Wong C, Swanson JM, Shumay E. (2013). Association between dopamine D4 receptor polymorphism and age related changes in brain glucose metabolism. PLoS One, 8(5):e63492.(1-3):178-85. Publications continued... 1 Dr. Rita Goldstein and Dr. Alia-Klein continued... Recent Publications: • Moeller SJ, Parvaz MA, Shumay E, Beebe-Wang N, Konova AB, Alia-Klein N, Volkow ND, Goldstein RZ. (2013). Gene x abstinence effects on drug cue reactivity in addiction: multimodal evidence. Journal of Neuroscience, 33 (24):10027–1003. • Moeller SJ, Beebe-Wang N, Woicik PA, Konova AB, Maloney T, Goldstein RZ. (2013). Choice to view cocaine images predicts concurrent and prospective drug use in cocaine addiction. Drug and Alcohol Dependence, 1;130 (1-3):178-85. • Konova AB, Moeller SJ, Tomasi D, Volkow ND, Goldstein RZ. (2013). Effects of methylphenidate on resting-state functional connectivity of the mesocorticolimbic dopamine pathways in cocaine addiction. JAMA Psychiatry, 1;70 (8):857-68. • Gkirtzou K, Honorio J, Samaras D, Goldstein RZ, Blaschko MB. (2013). fMRI analysis of cocaine addiction using k-support sparsity. IEEE International Symposium on Biomedical Imaging. • Gkirtzou K, Honorio J, Samaras D, Goldstein RZ, Blaschko MB. (2013). fMRI Analysis with Sparse Weisfeiler- Lehman Graph Statistics. In Proc MICCAI (MLMI workshop), accepted. Asbell Lab (Ophthalmology) Congratulations to Dr. Asbell on becoming the Editor in Chief of Eye & Contact Lens - Science and clinical pracatice; Journal of the CLAO (Contact Lens Association of Ophthalmologists) Buxbaum Lab (Psychiatry) Recent Publications: • Soorya L, Kolevzon A, Zweifach J, Lim T, Dobry Y, Schwartz L, Frank Y, Wang AT, Cai G, Parkhomenko E, Halpern D, Grodberg D, Angarita B, Willner JP, Yang A, Canitano R, Chaplin W, Betancur C, Buxbaum JD. Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency. Mol Autism. 2013 Jun 11;4(1): 18. • Betancur C, Buxbaum JD. SHANK3 haploinsufficiency: a "common" but underdiagnosed highly penetrant monogenic cause of autism spectrum disorders. Mol Autism. 2013 Jun 11;4(1):17. • Schafer CM, Campbell NG, Cai G, Yu F, Makarov V, Yoon S, Daly MJ, Gibbs RA, Schellenberg GD, Devlin B, Sutcliffe JS, Buxbaum JD, Roeder K. Whole exome sequencing reveals minimal differences between cell line and whole blood derived DNA. Genomics. 2013 Jun 3. [Epub ahead of print] • Smith RG, Reichenberg A, Kember RL, Buxbaum JD, Schalkwyk LC, Fernandes C, Mill J. Advanced paternal age is associated with altered DNA methylation at brain-expressed imprinted loci in inbred mice: implications for neuropsychiatric disease. Mol Psychiatry. 2013 Jun;18(6):635-6. • Noh HJ, Ponting CP, Boulding HC, Meader S, Betancur C, Buxbaum JD, Pinto D, Marshall CR, Lionel AC, Scherer SW, Webber C. Network topologies and convergent aetiologies arising from deletions and duplications observed in individuals with autism. PLoS Genet. 2013 Jun;9(6):e1003523. Epub 2013 Jun 6. • Buxbaum JD, Baron-Cohen S. DSM-5: the debate continues. Mol Autism. 2013 May 15;4(1):11. • Ionita-Laza I, Lee S, Makarov V, Buxbaum JD, Lin X. Sequence Kernel Association Tests for the Combined Effect of Rare and Common Variants. Am J Hum Genet. 2013 May 14. [Epub ahead of print] • Bozdagi O, Tavassoli T, Buxbaum JD. Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay. Mol Autism. 2013 Apr 27;4(1):9. 2 2 Clem Lab (Neuroscience) Congratulations to Dr. Clem on receiving the highly celebrated 2013 BBRF Young Investigator Grant! Recent publication: • Clem RL, Huganir RL. Norepinephrine Enhances a Discrete Form of Long-Term Depression during Fear Memory Storage. J Neurosci. 2013 Jul 17;33(29):11825-32. Ehrlich-Gandy Labs (Neurology) Recent Publication: • Gandy S, Heppner FL. Microglia as dynamic and essential components of the amyloid hypothesis. Neuron. 2013 May 22;78(4):575-7. doi: 10.1016/j.neuron. 2013.05.007. Filizola Lab (Structural and Chemical Biology) • The Filizola lab welcomes summer student Robert Colef from New York University. • Dr. Filizola serves as an external examiner for the PhD thesis defense of student Klara Felsovalyi from Columbia University. • Dr. Filizola becomes a regular member of the Biophysics of Neural Systems (BPNS) Study Section, Center for Scientific Review, National Institutes of Health. • Dr. Filizola becomes an Advisory Board Member for the Center for Therapeutic Antibody Development (CTAD) of the Experimental Therapeutics Institute at Mount Sinai. • Recent PNAS publication in collaboration with the Devi lab receives media coverage; http://medicalxpress.com/ news/2013-07-chemical-compound-alternative-opioid-pain.html • Dr. Filizola edits a book entitled “G Protein-Coupled Receptor Modeling and Simulation” for Springer Science + Business Media. The book includes state-of-the-art views on modeling and simulation by recognized experts with an established reputation in the development and/or application of computational methods to G Protein-Coupled Receptors (GPCRs), the targets for as many as half of currently marketed drugs. Expected publication date of the book is September 2013, and each individual chapter will be indexed in Pubmed. Recent Publications: • Gomes I, Fujita W, Gupta A, Saldanha AS, Negri A, Pinello CE, Roberts E, Filizola M, Hodder P, and Devi LA “Identification of a µOR-δOR heteromer-biased agonist with antinociceptive activity” Proc. Natl. Acad. Sci. USA (2013) 110(29):12072-7. • G Protein-Coupled Receptors – Modeling and Simulation; Advances in Experimental Medicine and Biology series; Publisher: Springer; Editor: Marta Filizola; in press. • Johnston, J.M. and Filizola, M. “Beyond Standard Molecular Dynamics: Investigating the Molecular Mechanisms of G Protein-Coupled Receptors with Enhanced Molecular Dynamics Methods” In: G Protein-Coupled Receptors – Modeling and Simulation ; Advances in Experimental Medicine and Biology series; Publisher: Springer; Editor: Marta Filizola; in press. 3 Dr. Sophia Frangou (Psychiatry) The Psychosis Research Program welcomes three new members: Dr. Danai Dima, Ms. Arriella Carlin and Mr. Alexander Rasgon. *New* Psychosis Research Club The Psychosis
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