On the Shoulders of Giants Scientific Symposium
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ON THE SHOULDERS OF GIANTS SCIENTIFIC SYMPOSIUM Celebrating W. Thomas Boyce, MD Professor Emeritus Lisa and John Pritzker Distinguished Professor of Developmental Health at the University of California, San Francisco Recipient of the 2020 Sarah Gund Prize for Research and Mentorship in Child Mental Health Tuesday, October 6, 2020 5 PM – 8 PM EST Welcome Welcome to our 10th annual On the Shoulders of Giants Scientific Symposium, the Child Mind Institute’s celebration of scientific achievement in child and adolescent psychiatry, psychology and developmental neuroscience. The symposium pays tribute to the winner of the Child Mind Institute’s Sarah Gund Prize for Research and Mentorship in Child Mental Health. The award is given each year to a leader in the field chosen by our Scientific Research Council for outstanding contributions to our understanding of the brain and behavior and dedication to scientific collaboration and mentorship. 2 Child Mind Institute Program PART ONE: AWARDS AND PRESENTATIONS 5-6:30 PM EDT Welcome and Opening Remarks Harold S. Koplewicz, MD, President, Child Mind Institute Sarah Gund Prize for Research and Mentorship in Child Mental Health Presentation Sarah Gund, Psychoeducational Clinician Presentations The Tenderness of Childhood: Orchids, Dandelions, and the Intergenerationality of Developmental Science Tom Boyce, MD, Professor Emeritus, Lisa and John Pritzker Distinguished Professor of Developmental Health at the University of California, San Francisco, Recipient of the 2020 Sarah Gund Prize for Research and Mentorship in Child Mental Health Biological Embedding of Early Life Stress: Intergenerational Transmission, Reversibility, and Resilience Nicole Bush, PhD, Associate Professor, University of California, San Francisco From risk to resilience: Leveraging developmental science to improve the lives of adversity-exposed families. Danielle Roubinov, PhD, Assistant Professor, University of California, San Francisco 3 Child Mind Institute Program PART TWO: ROUND TABLE DISCUSSION FOCUSING ON RESEARCH AROUND CURRENT WORLD EVENTS 6:30-8 PM EDT Moderator: Nora Volkow MD, Director, National Institute on Drug Abuse (NIDA) Panelists: W. Thomas Boyce, MD, Xavier Castellanos, MD, Kenneth A. Dodge, PhD, Felton ‘Tony’ Earls, MD, Yasmin Hurd, PhD, Jerome Kagan, PhD, Thomas R. Insel, MD, John Weisz, PhD Closing Remarks Michael Milham, MD, PhD, Vice President of Research, Child Mind Institute 4 Child Mind Institute Bios W. Thomas Boyce, MD Professor Emeritus Lisa and John Pritzker Distinguished Professor of Developmental Health at the University of California, San Francisco Recipient of the 2020 Sarah Gund Prize for Research and Mentorship in Child Mental Health W. Tom Boyce, MD, is a leading expert on the interplay between neurobiological and psychosocial processes — an interplay that leads to socially partitioned differences in childhood health, development and disease. Studying the interactive influences of socio-economic adversities and neurobiological responses, Dr. Boyce has demonstrated how psychological stress and neurobiological reactivity to aversive social contexts operate conjointly to produce both physical and mental health disorders in childhood populations. A central goal of his work is to develop a new synthesis between biomedical and social epidemiologic accounts of human pathogenesis and to articulate the public health implications of that synthetic view. He is professor emeritus of pediatrics and psychiatry at the University of California, San Francisco, where he formerly served as Lisa and John Pritzker Distinguished Professor of Developmental and Behavioral Health. He previously taught at the University of California, Berkeley and at the University of British Columbia. He is the author of the book The Orchid and the Dandelion: Why Some Children Struggle and How All Can Thrive, which was published in 2019. 5 Child Mind Institute Bios Nicki Bush, PhD, is an Associate Professor in the University of California, San Francisco departments of Psychiatry and Pediatrics and the Director of Research for the Division of Developmental Medicine. Dr. Bush’s research focuses on the manner in which early social contexts interface with individual differences to affect developmental trajectories across the life course. She examines how socioeconomic, parental, and environmental risks for maladaptive behavior and developmental psychopathology are modulated by individual differences in children’s temperamental, neurobiological, and genetic reactivity to stress. She also investigates the ways in which contextual experiences of adversity become biologically embedded by changing children’s developing physiologic systems and epigenetic processes, thereby shaping individual differences that mediate and moderate the effects of context on trajectories of development and mental health. Her research has examined relations among biobehavioral predispositions (e.g., temperament and physiology) and stressful life circumstances (e.g., poverty, parenting, and neighborhood) in the prediction of a broad range of children's mental health outcomes. Her examinations of how social disadvantage interacts with and alters children’s biological stress response systems aim to clarify the etiology of children’s mental and physical health outcomes and subsequent adult health. 6 Child Mind Institute Bios Danielle Roubinov, PhD, is a licensed Clinical Psychologist and Assistant Professor in the University of California, San Francisco Department of Psychiatry. She joined the UCSF faculty in 2017, following a two-year fellowship in developmental psychobiology in the UCSF Department of Pediatrics. Dr. Roubinov’s research examines the pathways and mechanisms through which exposure to adversity early in life shapes children’s trajectories of physical and psychological health. A particular focus of her work is on children’s developing stress response systems, with a goal to understand how environmental contexts become “biologically embedded” to influence health outcomes across the lifespan. By understanding the “how, when, and for whom” of early trauma and its effects on children’s development, she aims to help develop a tailored prevention and intervention program for at-risk children and families. She is currently the Principal Investigator of a 5-year Career Development Award (K23) from the National Institute of Mental Health (NIMH) that focuses on understanding and treating symptoms of depression and anxiety during early childhood. As part of this grant, she directs the ABC Study. 7 Child Mind Institute Bios Nora D. Volkow, MD, is Director of the National Institute on Drug Abuse (NIDA) at the National Institutes of Health. NIDA supports most of the world’s research on the health aspects of drug use and addiction. Dr. Volkow’s work has been instrumental in demonstrating that drug addiction is a disease of the human brain. As a research psychiatrist and scientist, Dr. Volkow pioneered the use of brain imaging to investigate the toxic and addictive properties of abusable drugs. Her studies have documented changes in the dopamine system affecting, among others, the functions of frontal brain regions involved with motivation and self-regulation in addiction. She has also made important contributions to the neurobiology of obesity, ADHD, and aging and to the imaging field. 8 Child Mind Institute Bios Xavier Castellanos MD, is an endowed Professor of Child & Adolescent Psychiatry and Professor of Radiology and Neuroscience at the NYU Langone Medical Center. He has been a research psychiatrist at the Nathan Kline Institute since 2006, with a focus on using intrinsic functional connectivity-based approaches in human and translational studies. Leading up to his current work, Dr. Castellanos studied Chomskian linguistics at Vassar College, experimental psychology at the University of New Orleans, and medicine at Louisiana State University in Shreveport. He was in the first cohort of “triple board” residents (combined training in pediatrics, psychiatry, and child and adolescent psychiatry) at the University of Kentucky, after which he spent a decade conducting child psychiatry research at the National Institute of Mental Health in Bethesda. In 2001, he moved to his current position at New York University. He was an early advocate of examining low-frequency fluctuations in brain function and in behavior — both of which have become mainstream lines of investigation. He has been consistently identified as among the top 1% of cited scientists in psychiatric neuroscience. Dr. Castellanos has served on many national and international review committees and was Vice-Chair of the American Psychiatric Association DSM-5 Workgroup on ADHD. 9 Child Mind Institute Bios Kenneth A. Dodge PhD, is the William McDougall Distinguished Professor of Public Policy and Professor of Psychology and Neuroscience at Duke University. He is also the founding and past director of the Center for Child and Family Policy, as well as the founder of Family Connects International. Dr. Dodge is a leading scholar in the development and prevention of aggressive and violent behaviors. Dr. Dodge’s work provides a model for understanding how some young children grow up to engage in aggression and violence and provides a framework for intervening early to prevent the costly consequences of violence for children and their communities. Dr. Dodge's research has resulted in the Family Connects Program, an evidence-based, population health approach to supporting families of newborn infants. Piloted