From: ITNDaily Subject: Mount Sinai In The News - February 5, 2018 Date: Monday, February 05, 2018 3:03:34 PM Attachments: ATT00001.txt

In the News February 5, 2018

Genetic Engineering & Biotechnology News – February 5 Grape-Derived Compounds May Help To Prevent Scientists have identified two grape-derived compounds that can effectively help to treat and protect against stress-induced depression in mice, and which could represent promising new candidates for treating depression in humans. The compounds, dihydrocaffeic acid (DHCA) and malvidin-3'-O- glucoside (Mal-gluc), trigger epigenetic changes in genes that affect inflammation and synaptic plasticity, mechanisms that aren’t addressed by current antidepressants. “Our approach to use a combination treatment of DHCA and Mal-gluc to simultaneously inhibit peripheral inflammation and modulate synaptic plasticity in the brain works synergistically to optimize resilience against chronic stress-induced depression-like phenotypes,” said lead researcher, Giulio Maria Pasinetti, PhD, MD, Saunders professor of and program director of the Center for Molecular Integrative Neuroresilience at the Icahn School of Medicine at Mount Sinai. “The discovery of these new, natural grape-derived compounds targeting cellular and molecular pathways associated with inflammation may provide an effective way to treat a subset of people with depression and , a condition that affects so many people." - Giulio Maria Pasinetti, PhD, MD, Saunders Professor, Neurology, Program Director, Center for Molecular Integrative Neuroresilience, Icahn School of Medicine at Mount Sinai Learn more: https://www.genengnews.com/gen-news-highlights/grape-derived-compounds-may-help- to-prevent-depression/81255456 Additional coverage: Healthcare Journal https://journalhealthcare.com/72/machine-learning-natural-language-processing- used-to-generate-clinical-labels-of-medical-scans/ Doctor NDTV https://doctor.ndtv.com/living-healthy/grape-derived-compounds-may-help-treat- depression-says-study-1808631 India Today https://www.indiatoday.in/pti-feed/story/grape-derived-compounds-may-help-treat- depression-1161684-2018-02-04 The Inquisitr https://www.inquisitr.com/4771101/grape-derived-compounds-could-help-treat-depression- a-new-study-reveals/ Laboratory Equipment https://www.laboratoryequipment.com/news/2018/02/grape-derived-compounds- may-promote-resilience-against-depression Medical News Today https://www.medicalnewstoday.com/articles/320830.php

Politico New York – February 5 Off Label — Dan Goldberg Zyrtec, the allergy medicine, may reduce relapses of demyelinating inflammatory disease neuromyelitis optica, according to Dr. Ilana Katz Sand, assistant professor of Neurology at the Icahn School of Medicine. - Ilana Katz Sand, MD, Assistant Professor, Neurology, Icahn School of Medicine at Mount Sinai Learn more: https://www.politicopro.com/states/new-york/newsletters/politico-new-york-health- care/2018/02/05/h-h-to-announce-new-care-management-program-030285

American Council on Science and Health – February 5 Machines Learn To Mimic Physician’s Thought – Kicking It Old School — Chuck Dinerstein The advance of machines into medical diagnostics continues. Machines learn based upon a large dataset of images and linked conclusion - information on whether cancer or diabetic retinopathy or some other condition is present. It should therefore come as no surprise that having not provided information on how humans reach conclusions the machines found their own path, hidden from our understanding. This opacity and our inability to have faith in conclusions we cannot understand represents a profound stumbling block to adoption of these tools. The authors of a study in Radiology are taking a new, well really old, approach to explanation. Using radiology reports to detect expert’s thinking is a beautiful insight. By abstracting thousands of reports, machines can be given a crowd-sourced structured description of images, descriptions that could form the basis for explanations we can more readily comprehend. But first computers need to learn radiologist’s structured approach, the subject of this study. - Eric Oermann, MD, Instructor, Neurosurgery, Icahn School of Medicine at Mount Sinai - John Zech, Medical Student, Icahn School of Medicine at Mount Sinai - Joshua Bederson, MD, Professor, System Chair, Neurosurgery, Mount Sinai Health System, Clinical Director, Neurosurgery Simulation Core Learn more: https://www.acsh.org/news/2018/02/05/machines-learn-mimic-physicians-thought-kicking- it-old-school-12521

Radiology Business – January 30 Otolaryngology Training Programs Cover Radiology Services, But Lack Structure — Subrata Thakar Though most otolaryngology residency programs have a radiology curriculum within their residency program, a thorough review of radiology education requirements from the Accreditation Council for Graduate Medical Education (ACGME) is needed, according to a new study published in JAMA Otolaryngology – Head & Neck Surgery. “Otolaryngologists rely on various head and neck imaging modalities on a daily basis,” wrote authors Kirkland N. Lozada, MD, resident physician at the New York Eye and Ear Infirmary of Mount Sinai, and Joseph M. Bernstein, MD, associate professor of otolaryngology at the Icahn School of Medicine at Mount Sinai. “Experience with ordering and interpreting radiologic studies is an important competency for all graduating residents of otolaryngology programs. However, little is known how residency programs structure training in head and neck imaging throughout the five years.” They added that given the considerable variability encountered in radiology education, “we believe standardized program requirements will improve education across all programs, enhance the level of patient care, and further the disciplinary teamwork of otolaryngologists and radiologists.” - Joseph M. Bernstein, MD, Associate Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai Kirkland Lozada, MD, Resident Physician of Otolaryngology, New York Eye and Ear Infirmary of Mount Sinai Learn more: http://www.radiologybusiness.com/topics/practice-management/quality/otolaryngology- training-programs-cover-radiology-services-lack-structure-and-consistency

CBS News – February 5 More U.S. Teens Identify As Transgender Far more U.S. teens than previously thought are transgender or identify themselves using other nontraditional gender terms, with many rejecting the idea that girl and boy are the only options, research suggests. "I tend to use the analogy of sexual orientation," said John Steever, MD, assistant professor of pediatrics at the Icahn School of Medicine at Mount Sinai and director of special programs at the Mount Sinai Adolescent Health Center, explained in “Gender: The Space Between,” emphasizing that point that a binary definition is not sufficient. "Most people are familiar with being either straight or gay. And most people are familiar with the concept of being bisexual, attracted to both. So if you apply that construct to gender, then that opens up the idea that there is more than just boys, girls, men, women. There can be people who live in the spaces between that. And I'll often point out examples from pop culture — people like Grace Jones or David Bowie — people whose gender presentation is a little ambiguous." - John Steever, MD, Assistant Professor, Pediatrics, Icahn School of Medicine at Mount Sinai, Director, Special Programs, Mount Sinai Adolescent Health Center Learn more: https://www.cbsnews.com/news/more-u-s-teens-identify-as-transgender/

LongIsland.com – February 1 Governor Cuomo Announces $37.7 Million Awarded To Improve Access To Breast Cancer Screening Across New York State Governor Andrew M. Cuomo announced $37.7 million in funding as part of the “Get Screened, No Excuses” initiative to improve access to breast cancer screening for New Yorkers. Funds are being used to support peer educators in community settings, make patient navigators available to help women as they undergo screening and other necessary follow-up care, and operate mobile mammography vans in underserved neighborhoods to bring health services to New Yorkers. These statewide programs are successfully reducing barriers to breast cancer screening for women, including those who lack access to preventative health care because they are economically disadvantaged, live in underserved inner-cities, or live in remote rural areas. The Mount Sinai Hospital is one of the awardee’s that will receive funding for the mobile mammography initiative. - The Mount Sinai Hospital Learn more: https://www.longisland.com/news/02-01-18/governor-cuomo-announces-377-million- awarded-to-improve-access-to-breast-cancer-screening-across-new-york-state.html

Crain’s Health Pulse – February 5 State Health Department Helps Usher Behavioral-Health Providers Into Value-Based Era — Jonathan LaMantia As the state moves more of its Medicaid spending into payments that reward high-quality providers, a new program aims to accelerate progress on the behavioral-health side. The state is investing $60 million over the next three years through the Behavioral Health Value Based Payment Readiness program to get more providers up to speed. Some agencies have already begun experimenting with value-based payments. Institute for Community Living is participating in a pilot with Mount Sinai Health Partners and Healthfirst that reimburses providers for care delivered to people with Health and Recovery Plans, said David Woodlock, ICL's president and chief executive. HARP is the insurance plan for Medicaid recipients with mental health or substance-use conditions. - Mount Sinai Health Partners Learn more: http://www.crainsnewyork.com/article/20180205/PULSE/180209966/state-health-department- helps-usher-behavioral-health-providers-into (Subscription Required)

IBD News Today – February 5 Kenneth Rainin Foundation Gives $1.7 Million In ‘Synergy Awards’ For IBD Research — Iqra Mumal The Kenneth Rainin Foundation has given $1.7 million in prize money to support collaborative research into preventing and detecting inflammatory bowel disease. The Synergy Awards are aimed at getting experts to combine their research abilities towards a common goal, working together rather than independently. The foundation is also continuing to fund previous Synergy Award grantees that made significant progress in advancing their original research hypotheses. A project continuing to be funded with $100,000, is “The role of IBD in the fungal microbiota transmission from pregnant women to the offspring,” led by Inga Peter, PhD, professor of and genomic sciences at the Icahn School of Medicine at Mount Sinai and Jean-Frederic Colombel, MD, professor of medicine and gastroenterology at the Icahn School of Medicine at Mount Sinai and director of the Susan and Leonard Feinstein IBD clinical center at Mount Sinai. Another group that includes Saurabh Mehandru, MD, assistant professor of medicine and gastroenterology at the Icahn School of Medicine at Mount Sinai got $300,000 for their project, “Toward Identifying the unique pathology that explains Ulcerative Colitis distribution.” - Inga Peter, PhD, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai - Jean-Frédéric Colombel, MD, Professor, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai, Director, Susan and Leonard Feinstein IBD Clinical Center at Mount Sinai - Saurabh Mehandru, MD, Assistant Professor, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai Learn more: https://ibdnewstoday.com/2018/02/05/ibd-research-projects-win-1-7m-synergy-awards-from- kenneth-rainin-foundation/

Healio: Cardiology Today – February 2 Q&A: Awareness Of Women’s Heart Health Critical For Diagnosis And Treatment — Darlene Dobkowski The signs of CHD are sometimes different in women than in men, although knowledge gaps remain on how to diagnose and treat women with it. In honor of National Wear Red Day, which raises awareness that CHD is the leading cause of death in women, Mary Ann McLaughlin, MD, associate professor of medicine and cardiology at the Icahn School of Medicine at Mount Sinai, medical director of the cardiac health program and co-director of the women’s cardiac assessment and risk evaluation program at Mount Sinai Heart, talks about the importance of treating women with CHD and what to be aware of when caring for them. “Almost two-thirds of women who die suddenly of CHD have no previous symptoms that have been reported. What physicians are responsible to do is to make sure that woman understand which symptoms could be associated with heart disease and to discuss ways of preventing heart disease,” she said. - Mary Ann McLaughlin, MD, Associate Professor, Medicine, Cardiology, Assistant Professor, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, Medical Director, Cardiac Health Program, Co-Director, Women’s Cardiac Assessment and Risk Evaluation Program, The Mount Sinai Hospital Learn more: https://www.healio.com/cardiology/chd-prevention/news/online/%7B143a7667-0e3d-443d- b960-3040aace3048%7D/qa-awareness-of-womens-heart-health-critical-for-diagnosis-treatment

MD Alert – February 2 Community Program Helps Bangladeshi Patients In NYC Manage Diabetes— Marilynn Larkin A community-based, patient-centered intervention called DREAM led to improvements in the management of among Bangladeshi immigrants in New York City, researchers say. Reshmi Srinath, MD, assistant professor of medicine, endocrinology, diabetes and bone disease and director of the weight and metabolism program at the Icahn School of Medicine at Mount Sinai, said, “Diabetes management can be really challenging for physicians when there are language and health literacy barriers, and this study supports the concept of having a diabetes team which may include nurses, nurse practitioners, and community health workers to assist with patient care.” She added that the study also supports the concept that the more face-to-face time with the healthcare team, the better the outcome with diabetes. Expressing surprise that there were no significant differences in some of the outcomes between groups, Dr. Srinath suggested that “there may have been a placebo effect in the control group; just by being enrolled in the study, they were more focused on improving their diabetes.” - Reshmi Srinath, MD, Assistant Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Director, Weight and Metabolism Management Program, Icahn School of Medicine at Mount Sinai Learn more: http://www.mdalert.com/news/article/community-program-helps-bangladeshi-patients-in- nyc-manage-diabetes

MD Alert – February 5 Potentially Life-Threatening Gaps In Cardiomyopathy Care Documented In Europe — Marilynn Larkin The first European registry on cardiomyopathies reveals that more than a third are genetic, that familial screening is suboptimal, and that people with the life-threatening disorder may be missing out on life- saving treatment, researchers say. Usman Baber, MD, assistant professor of medicine and cardiology, and director of clinical biometrics at the cardiovascular institute at the Icahn School of Medicine at Mount Sinai said, “In contrast to clinical trial participants, ‘real-world’ patients with cardiomyopathies may differ in underlying risk and comorbid risk factors, with important implications for extending evidence- based guidelines to clinical practice.” He added, “The European Cardiomyopathy registry is clinically relevant by providing estimates of disease burden, contemporary treatments and longitudinal follow-up. These efforts will enable clinicians and health systems to identify gaps in care that might improve the overall prognosis and outcomes in cardiomyopathy patients.” - Usman Baber, MD, Assistant Professor, Medicine, Cardiology, Director, Clinical Biometrics, Cardiovascular Institute, Icahn School of Medicine at Mount Sinai Learn more: http://www.mdalert.com/news/article/potentially-life-threatening-gaps-in-cardiomyopathy- care-documented-in-europe

STAT News – February 2 High Doses Of Cellphone Radiation Linked To Some Cancers In Rats — Andrew Joseph Two recent major reports issued by federal scientists found that there was some evidence the type of radiation released from cellphones can cause certain forms of cancer in male rats, but the reports – which include many inconclusive findings – are not likely to quell the debate over whether cellphone radiation poses a threat to human health. Paolo Boffetta, MD, professor of hematology and medical oncology at the Icahn School of Medicine at Mount Sinai, who was not involved with the reports, said that because the studies suggested radiofrequency radiation could have a small carcinogenic effect, researchers should keep studying the subject to determine the level of risk. He added, “One should not just extrapolate these results to think there is a risk to humans.” - Paolo Boffetta, MD, Professor, Hematology, Medical Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://www.statnews.com/2018/02/02/cellphone-radiation-rodents/

The Curbsiders – February 5 Placebos, Nocebos, And The Doctor As A Placebo — Matthew Watto, MD Boost treatment efficacy and amplify the “doctor as a placebo” phenomenon with tips from placebo expert, Mark W. Green, MD, director of the center for headache and pain medicine, professor of neurology, anesthesiology and rehabilitation medicine at the Icahn School of Medicine at Mount Sinai. Topics in the podcast include what is the sugar pill actually doing to us? Why do we get a boost from taking medicine that have no active compounds within them? How does placebo work? How can it be leveraged? - Mark W. Green, MD, Director, Center for Headache and Pain Medicine, Professor, Neurology, Anesthesiology, Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai Learn more: http://thecurbsiders.com/internal-medicine-podcast/81-placebos-nocebos-doctor-placebo

Business Ghana – February 5 Is This Why You’re Tired, Suffer From Brain Fog, And Have Arthritis? — Steve Kroening, MD A study at the Icahn School of Medicine at Mount Sinai found a total of 167 different chemicals in the blood and urine samples of volunteers. There was an average of 91 toxins in each volunteer. The toxins included lead, dioxins, PCBs, phthalate DEHP, as well as compounds that have been banned for more than a quarter century. Of these 167 chemicals, 76 cause cancers in humans or animals, 94 are toxic to the brain and nervous system, and 79 cause birth defects or abnormal development. It’s likely, if not for sure, that each of us has multiple chemicals in our body that don’t need to be there. A healthy body can handle a certain number of chemicals. Unfortunately, we don’t know what the number is. And we don’t know when they begin to cause problems. We just know they do, and given enough time, they will cause problems for most of us. - Icahn School of Medicine at Mount Sinai Learn more: http://www.businessghana.com/site/news/General/158845/Is-this-why-you&

Healio – February 4 Ultrasound Guidance, Other Techniques Ensure Transradial Access Safety In Vascular Procedures — Erik Swain Ultrasound guidance and four other steps were identified as core factors for safely performing vascular procedures with transradial access by a speaker at the International Symposium on Endovascular Therapy (ISET). “If you follow these five steps, they form the core to safely perform transradial access for noncardiac interventions,” said Rahul S. Patel, MD, assistant professor of radiology and surgery at the Icahn School of Medicine at Mount Sinai. “Based on these steps, you can build all your interventions, including liver, renal and mesenteric interventions,” he said. - Rahul S. Patel, MD, Assistant Professor, Radiology, Surgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/cardiac-vascular- intervention/peripheral/news/online/%7B2b15f57a-582b-45b8-8588-31b6450598e0%7D/ultrasound- guidance-other-techniques-ensure-transradial-access-safety-in-vascular-procedures

Women’s Health – January 26 Five Reasons Why Your Belly Button Hurts — Colleen De Bellefonds Most of the time, we give little to no thought to our belly buttons. That is, until we feel a weird case of belly button pain. And while belly button pain can come and go, and be no big deal, sometimes, it’s a sign that somethings wrong. “People should really be making their first stop their primary care doctor to decide what’s important and what’s not, what’s worrisome and what’s not,” said Elana Maser, MD, assistant professor of gastroenterology at the Icahn School of Medicine at Mount Sinai. She also recommends keeping an eye out for red-flag symptoms: if you have a fever, there’s blood in your stool, you can’t keep food down, or you’re not urinating, immediately have someone take you to an emergency room. An inflammatory bowel disease that usually affects the small intestine and colon, Crohn’s disease can cause pain behind the belly button that feels like anything from a dull ache to a sharp, cramping pain that typically occurs 20 to 30 minutes after eating. “But when you make a Crohn’s diagnosis, it’s never made based solely on presence of abdominal pain. You need other symptoms,” said Dr. Maser. Those include severe diarrhea, fatigue, and weight loss. - Elana Maser, MD, Assistant Professor, Gastroenterology, Icahn School of Medicine at Mount Sinai Learn more: https://www.womenshealthmag.com/health/belly-button-pain

Refinery29 – February 1 Why The Star Of Groundbreaking Grey’s Anatomy Trans Story Seems Familiar — Kaitlin Reilly Grey’s Anatomy has a “groundbreaking” new storyline in the works, and has hired actress Candis Cayne to help tell it. Cayne will join the cast of the ABC series for multiple episodes as a trans woman who undergoes vaginoplasty surgery. Cayne’s storyline, was inspired by a real medical breakthrough that benefited the trans community. Hayley Anthony, a trans women, helped Jess Ting, MD, surgical director of Mount Sinai’s Center for Transgender Medicine and Surgery, develop new procedures for gender confirmation surgery. This isn’t the first time the show has tackled issues that some people face within the trans community. - Jess Ting, MD, Surgical Director, Mount Sinai’s Center for Transgender Medicine and Surgery, Assistant Professor, Plastic and Reconstructive Surgery, Icahn School of Medicine at Mount Sinai Learn more: http://www.refinery29.com/2018/02/189734/candis-cayne-greys-anatomy-trans-storyline Additional coverage: InStyle http://www.instyle.com/news/candis-cayne-greys-anatomy-transgender-story Metro http://metro.co.uk/2018/02/01/candis-cayne-joins-greys-anatomy-groundbreaking-transgender- storyline-spin-off-trailer-released-7280373/ Pink News http://www.pinknews.co.uk/2018/02/01/greys-anatomy-is-going-to-have-a-groundbreaking- transgender-storyline/ Christian Today https://www.christiantoday.com/article/greys-anatomy-cast-news-candis-cayne-to- appear-in-a-series-of-groundbreaking-trans-episodes/125250.htm

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200

From: ITNDaily Subject: Mount Sinai In The News - February 2, 2018 Date: Friday, February 02, 2018 12:49:28 PM Attachments: ATT00001.txt

In the News February 2, 2018

Long Island Herald – February 1 What The South Nassau-Mount Sinai Deal Means For Long Island— Peter Belfiore On January 24th, South Nassau announced its partnership with the Mount Sinai Health System. Upon arrival of a state regulatory review, the collaboration could have a profound impact on advanced medical care on the South Shore of Long Island. As part of the affiliation agreement, South Nassau will become the eighth hospital in Mount Sinai’s network, which already has eleven clinics on the Island as well as the Icahn School of Medicine at Mount Sinai, a respected center for medical research and development. Mount Sinai will contribute $120 million over five years to help fund construction projects South Nassau has planned or that are under way. “We felt that having an institutional partner on the Island was critical to establishing a regional presence on Long Island to be added to our practices,” said Arthur Klein, MD, president of the Mount Sinai Health Network. South Nassau’s president and chief executive officer, Richard Murphy, will report to the existing South Nassau board as well as to Kenneth L. Davis, MD, president and CEO of the Mount Sinai Health System. A name change is in the works as well, but talks are still in the early stages. - Kenneth L. Davis, MD, President, CEO, Mount Sinai Health System - Arthur Klein, MD, President, Mount Sinai Health Network Learn more: http://www.liherald.com/stories/what-the-south-nassau-mount-sinai-deal-means-for-long-island,99646

My Palm Beach Post – February 1 Out-Of-State Providers Expand Into Palm Beach County — Alexandra Clough Three New York-based providers, Mount Sinai Health System, NYU Langone, and Hospital for Special Surgery, have opened or are set to open medical offices in downtown West Palm Beach. Mount Sinai partnered with Jupiter Medical Center so that patients needing hospitalization for surgeries or other care can have access to a nearby in-patient facility. - Mount Sinai Health System Learn more: http://www.mypalmbeachpost.com/business/cleveland-clinic-open-clinic-wellington-charts-growth- pbc/HxfZ1ygNuSIzV3uU3bvlOM/ Additional coverage: Becker’s ASC Review https://www.beckersasc.com/gastroenterology-and-endoscopy/boston-medical-center-mount-sinai-health- system-more-5-gi-practices-in-the-news.html

News Medical and Life Sciences – February 1 Research Can Be First Step In Harnessing Power Of Artificial Intelligence To Interpret Medical Scans Researchers used machine learning techniques, including natural language processing algorithms, to identify clinical concepts in radiologist reports for CT scans, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published in the journal Radiology. “The language used in radiology has a natural structure, which makes it amenable to machine learning," said senior author Eric Oermann, MD, instructor in the department of neurosurgery at the Icahn School of Medicine at Mount Sinai. "Machine learning models built upon massive radiological text datasets can facilitate the training of future artificial intelligence-based systems for analyzing radiological images." Study co-author, John Zech, a medical student at the Icahn School of Medicine at Mount Sinai said, “The ultimate goal is to create algorithms that help doctors accurately diagnose patients.” Joshua Bederson, MD, professor and system chair for the department of neurosurgery at the Mount Sinai Health System and clinical director of the neurosurgery simulation core as well as the study co-author, explained, “Research like this turns big data into useful data and is the critical first step in harnessing the power of artificial intelligence to help patients.” - Eric Oermann, MD, Instructor, Neurosurgery, Icahn School of Medicine at Mount Sinai - John Zech, Medical Student, Icahn School of Medicine at Mount Sinai - Joshua Bederson, MD, Professor, System Chair, Neurosurgery, Mount Sinai Health System, Clinical Director, Neurosurgery Simulation Core Learn more: https://www.news-medical.net/news/20180201/Research-can-be-first-step-in-harnessing-power-of-artificial-intelligence- to-interpret-medical-scans.aspx Additional coverage: Politico New York https://www.politico.com/states/new-york/newsletters/politico-new-york-health-care/2018/02/02/whats-in-de- blasios-budget-030119 Clinical Innovation & Technology http://www.clinical-innovation.com/topics/artificial-intelligence/ai-interprets-radiology-reports-91- percent-accuracy Health Data Management https://www.healthdatamanagement.com/news/machine-learning-can-understand-text-reports-written-by- radiologists

The Scientist – February 2 Experimental Drug Relieves Blast-Related PTSD In A Rat Model Of Traumatic Brain Injury— Viviane Callier People who experience blast-related trauma to the brain, a condition that has become more and more common among combat veterans, can later experience depression and heightened anxiety, even in the absence of a psychological stressor. In search of a more- effective drug, researchers have found that a compound that blocks certain glutamate receptors in the brain reverses many of the post-traumatic stress disorder (PTSD)-like symptoms that appear after rats endure a blast injury. Returning veterans often exhibit long-lasting behavioral symptoms, but there is “controversy over how much of this is TBI and how much is PTSD,” said senior author, Gregory A. Elder, MD, research professor of and neurology at the Icahn School of Medicine at Mount Sinai. While PTSD is a psychologically based reaction to a stressor that isn’t necessarily associated with a physical injury, TBI is a physical injury to the brain, he explained. As Dr. Elder was exploring TBI with this rat model, his colleague, Sam Gandy, MD, PhD, professor of neurology and psychiatry at the Icahn School of Medicine at Mount Sinai was investigating Alzheimer’s disease in a different rat model. Dr. Gandy found that a compound called BCI-838 improved memory and reduced anxiety in these animals. As Dr. Elder and his team are now working to understand how the drug affects the pathophysiology in the brain after blast injury, Dr. Gandy is pursuing human clinical trials of BCI-838 among combat vets. - Gregory A. Elder, MD, Research Professor, Psychiatry, Neurology, Icahn School of Medicine at Mount Sinai - Samuel Gandy, MD, PhD, Professor, Neurology, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.the-scientist.com/?articles.view/articleNo/51538/title/Experimental-Drug-Relieves-Blast-Related-PTSD-in-a- Rat-Model-of-Traumatic-Brain-Injury/

MedPage Today – February 1 Morning Break Among adults with mental illness, white people were significantly more likely to lack the money for healthcare or suffer delays in care than any other race, according to a Mount Sinai study. - Judith Weissman, PhD, JD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai - Dolores Malaspina, MD, MPH, Director, Psychosis Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/primarycare/generalprimarycare/70884

Lab Manager – February 2 Researchers Discover Possible Link Between Diet And Back Injuries In a first-of-its-kind study, Mount Sinai researchers have found a possible link between a poor diet and back injuries, especially in women. The study suggests that following a specific type of diet that excludes fast foods and highly processed foods could decrease vertebral fractures and prevent bone loss as people age. “This is the first study to show that high-AGE diets can directly result in altered vertebral bone quality with inferior biomechanical properties, and with a stronger influence on females than males. This study is particularly important since it focuses attention on the importance of nutrition in promoting spinal health and susceptibility to injury, expanding our thinking beyond genetics and mechanical injuries. By highlighting new ways of thinking about spine physiology, these studies can help identify innovative interventions,” said lead researcher James Iatridis, PhD, professor and vice chair for research at the Leni and Peter W. May Department of Orthopaedics at the Icahn School of Medicine at Mount Sinai. “This study could lead to future breakthroughs as we further investigate the biological and biomechanical causes for these findings,” explained Svenja Illien-Jünger, PhD, assistant professor of orthopaedics at the Icahn School of Medicine. “In addition to improved diets, a better understanding of what could lead to back pain and spine disease can help clinicians and researchers develop novel treatments.” - James Iatridis, PhD, Professor, Vice Chair, Research, Leni and Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai - Svenja Illien-Junger, PhD, Assistant Professor, Orthopaedics, Icahn School of Medicine at Mount Sinai Learn more: http://www.labmanager.com/news/2018/02/researchers-discover-possible-link-between-diet-and-back-injuries#.WnR- hdKPJQI Additional coverage: Politico New York https://www.politico.com/states/new-york/newsletters/politico-new-york-health-care/2018/02/02/whats-in-de- blasios-budget-030119

Alzheimer’s & Weekly – February 2 Alzheimer’s & Vitamin E Vitamin E may slow down Alzheimer’s and ease caregiving. The research was performed by experts at the Icahn School of Medicine at Mount Sinai working with Veterans Administration Medical Centers. The study is published in the Journal of the American Medical Association. The researchers investigated vitamin E as α-Tocopherol, an important fat-soluble antioxidant. Mary Sano, PhD, associate dean of clinical research and professor of psychiatry at the Icahn School of Medicine at Mount Sinai, was the trial co-investigator. She said, “Since the cholinesterase inhibitors, we have had very little to offer patients with mild-to-moderate dementia. This trial showed that vitamin E delays progression of functional decline by 19 percent per year, which translates into 6.2 months benefit over placebo.” The finding is valuable because vitamin E is easy to purchase at local drugstores and it is also inexpensive. The clinical trial investigators believe it can be recommended as a treatment strategy, based on the double-blind randomized controlled trial. - Mary Sano, PhD, Associate Dean, Clinical Research, Professor, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: http://www.alzheimersweekly.com/2014/01/can-vitamin-e-slow-down-alzheimers.html

Mother Jones – February 2 The Flu Has Killed 37 Children So Far, But The Scientists Who Study It Are Short On Funds — Kiera Butler We’re only about halfway through flu season, and the influenza virus has already done a number on the United States. According to the Centers for Disease Control and Prevention, nearly 12,000 people had been hospitalized and at least 37 children have died. To make matters worse, our flu defenses are strained. Hospitals are packed. In many places, pharmacies are running out of the antiviral medication Tamiflu. If we can expect a nasty strain to emerge every few years, and an extremely deadly on to pop up now and again, why haven’t we figured out a better way to defend ourselves? One reason is that funding for flu research is notoriously paltry. Even though the virus kills tens of thousands of Americans each year, neither Congress nor Big Pharma see it as a priority. Peter Palese, PhD, professor and chair of microbiology at the Icahn School of Medicine at Mount Sinai is working to develop a universal vaccine for all strains, an accomplishment that would eliminate that guesswork that goes into concocting annual flu shots. “Pharma companies won’t pay for research,” Dr. Palese explained. “We need a health NIH. We rely on it.” - Peter Palese, PhD, Professor, Chair, Microbiology, Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.motherjones.com/politics/2018/02/the-flu-has-killed-37-children-so-far-this-year-but-scientists-who-study- it-still-have-to-beg-for-funds/

CBS New York – February 1 Fight The Flu Travel Tips— Vanessa Murdock Do you have plans to travel during the height of flu season? As mid-winter recess hits, many will be flying, but it is also peak flu season. Peter Shearer, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and medical director of the emergency department at The Mount Sinai Hospital said, “Although they do a good job of cleaning the cabin between flights, they don’t necessarily go around and sanitize everything.” He added that you should absolutely bring your own sanitizing wipes and use them. According to a 2015 study by Travel Math, the seat-back tray table is the dirtiest place on the plane, carrying more germs than the toilet handle, seatbelt buckle, and overhead bin compartment combined. “If you end up on a plane and it’s packed and there’s someone next to you that’s coughing constantly, bringing your own face mask would not be a bad idea,” added Dr. Shearer. The recycled dry air makes it easier for flu and other respiratory illnesses to get passed around, said Dr. Shearer. - Peter Shearer, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Emergency Department, The Mount Sinai Hospital Learn more: http://newyork.cbslocal.com/2018/02/01/flu-hospital-restrictions/

ABC News – February 1 Dabbing: Smoking Marijuana Extract With High Levels Of THC Is Growing In Popularity — CeFaan Kim There’s a new drug with THC that’s not the marijuana you’re used to. Users have to heat it with a blowtorch to smoke it. It’s marijuana extract; otherwise known as concentrated . The use of it is called dabbing. Dabbing is illegal in New York, but it is legal in California, Colorado, and Washington. Experts say its highly likely it will be legalized in New York in just a few years. “There have definitely been cases where people have overdosed on dabbing,” said Yasmin Hurd, PhD, professor of psychiatry, , and systems therapeutics at the Icahn School of Medicine at Mount Sinai, chair of Ward-Coleman Translational Neuroscience, and director of the center for addictive disorders at the Mount Sinai Health System. “For developing brain, we know that THC has long term impact even on lower concentrations, so no one yet knows what these high concentrations of THC will do because they’re very new.” But medical experts say it can cause psychosis, rapid heartbeat, and blackouts. Traditional marijuana has a THC concentration of about 20 percent. Dabbing has close to 100 percent. -Yasmin Hurd, PhD, Professor, Psychiatry, Neuroscience, Pharmacology, Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Chair, Ward-Coleman Translational Neuroscience, Director of the Center for Addictive Disorders, Mount Sinai Health System Learn more: http://abc7ny.com/health/dabbing-concentrated-cannabis-with-high-thc-is-growing-in-popularity/3017476/

Renal & Urology News – February 1 LDR Brachytherapy For Prostate Cancer Offers Excellent Survival— Jody A. Charnow Low-dose-rate brachytherapy (LDR-BT) for localized prostate cancer is associated with excellent disease-specific survival rates and appears to be an effective alternative to radical prostatectomy, researchers concluded. In a study that included 757 men with localized PCa who underwent definitive LDR-BT from 1990 to 2006 and followed up for more than ten years, Stanislav Lazarev, MD, chief resident of radiation oncology at the Icahn School of Medicine at Mount Sinai, and colleagues found that 88.6 percent of patients were alive at the time of their analysis, 1.5 percent died from PCa. And 13.9 percent experienced biochemical failure, according to study findings published in BJU International. Among the patients who experienced biochemical failure, 18% did so more than 10 years after brachytherapy, “which justifies their continued follow-up,” the researchers stated. - Stanislav Lazarev, MD, Chief Resident, Radiation Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://www.renalandurologynews.com/prostate-cancer/brachytherapy-prostate-cancer-survival/article/740680/

Medical Xpress – February 1 Do NFL Players Face A Higher Risk Of Early Death? — Dennis Thompson New research suggests NFL players have a slightly higher risk of early death than a group of replacement players who stood in for a few games during a short league strike in the 1980s. The overall difference in death rates did not reach statistical significance, but NFL players were more likely than replacements to suffer deaths related to neurological disorders and drug overdoses, the study authors said. While interesting, the findings are “kind of murky,” said David Putrino, PhD, director of rehabilitation innovation at the Mount Sinai Health System and assistant professor of rehabilitation medicine at the Icahn School of Medicine at Mount Sinai. It's difficult to form any strong conclusions, given that the players came from a variety of backgrounds and faced a variety of injuries that largely depended on which position they played, said Dr. Putrino, who wasn’t involved in the study. "The one thing we can say for certain is that you can't make overarching statements about NFL players," he added. On the other hand, NFL players are asked to do things that could jeopardize their health, Dr. Putrino acknowledged. "They take a lot of punishment, and it's not just the NFL, it's all elite sports," Dr. Putrino said. "The wear and tear on the body is significant." - David Putrino, PhD, Assistant Professor, Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, Director, Rehabilitation Innovation, Mount Sinai Health System Learn more: https://medicalxpress.com/news/2018-02-nfl-players-higher-early-death.html Additional coverage: WebMD https://www.webmd.com/brain/news/20180201/do-nfl-players-face-a-higher-risk-of-early-death#1 Health & Medicine News http://hmnews.org/psychology-news/cluster982837900/ U.S. News & World Report https://health.usnews.com/health-care/articles/2018-02-01/do-nfl-players-face-a-higher-risk-of-early-death UPI https://www.upi.com/Health_News/2018/02/01/NFL-players-may-face-risk-of-early-death-Study/8431517515208/ The Philadelphia Inquirer http://www.philly.com/philly/health/topics/HealthDay730685_20180201_Do_NFL_Players_Face_a_Higher_Risk_of_Early_Death_.html NewsMax Health https://www.newsmax.com/health/health-news/nfl-players-die-younger/2018/02/01/id/840908/

Runner’s World – February 1 Signs You Suffer From Supination, And How To Fix It — Jenny McCoy Supination, also known as underpronation, is the insufficient inward roll of the foot after landing. It may be the result of having a naturally high-arching foot, or it may also be caused by certain muscle weakness in your calves, ankles, or feet that are a result of ill- fitting running shoes, improper gait, or previous injuries. When a supinator runs, the outside of the heel of his/her foot hits the ground first, said Steven Weinfeld, MD, associate professor of orthopaedics at the Icahn School of Medicine at Mount Sinai and chief of foot and ankle surgery at The Mount Sinai Hospital. Because the foot does not sufficiently roll inward after landing, the force of impact remains concentrated on that one specific part of the foot. An easy way to tell if you’re doing this regularly is if your running shoes wear out quickly and unevenly, with more breakdown on the outer side of the shoe. To check if your shoes have uneven wear, place them on a flat surface. If they tilt outward, supination is likely in play. - Steven Weinfeld, MD, Associate Professor, Orthopaedics, Icahn School of Medicine at Mount Sinai, Chief, Foot and Ankle Surgery, The Mount Sinai Hospital Learn more: https://www.runnersworld.com/feet/what-to-know-about-supination

NPR News – February 1 Can Cooking Classes Keep Chronic Heart Failure Patients Out Of The Hospital? — Lela Nargi Shirline Burbanks is one of the 6.5 million Americans suffering from congestive heart failure (CHF). But unlike most other CHF patients in the U.S., within hours of her admittance, Burbanks was met at her bedside with an offer: to sign up for cooking classes. The offer came from a research coordinator at the Goldring Center for Culinary Medicine at Tulane. According to Mary Ann McLaughlin, MD, associate professor of medicine and cardiology at the Icahn School of Medicine at Mount Sinai, medical director of the cardiac health program, and co-director of the women’s cardiac assessment and risk evaluation program at The Mount Sinai Hospital said, “Anytime you have patients with severe chronic conditions, socialization has an important impact. Food bonds people, and they can learn from each other and share their fears and concerns.” - Mary Ann McLaughlin, MD, Associate Professor, Medicine, Cardiology, Assistant Professor, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, Medical Director, Cardiac Health Program, Co-Director, Women’s Cardiac Assessment and Risk Evaluation Program, The Mount Sinai Hospital Learn more: https://www.npr.org/sections/thesalt/2018/02/01/581891870/can-cooking-classes-keep-chronic-heart-failure-patients-out- of-the-hospital Additional coverage: Associated News http://associatednews.us/content/2018/02/01/can-cooking-classes-keep-chronic-heart-failure-patients-out-of-the- hospital/ New England Public Radio http://nepr.net/post/can-cooking-classes-keep-chronic-heart-failure-patients-out-hospital#stream/0

Women’s Health – January 31 Do You Have Mono, Or Are You Just Really Tired? — Kristin Canning The older people are when they get mono, the worse their mononucleosis symptoms tend to be, said Shanna Levine, MD, instructor of general internal medicine at the Icahn School of Medicine at Mount Sinai. The most common mono symptom is fatigue. “It feels like your body is moving in slow motion,” Dr. Levine added. She explained that, with mono, your immune system gets so busy trying to fight off infection, that your body doesn’t have the energy to perform even simple, daily activities. A critical component to your immune system is your lymph nodes, which usually get swollen when you’re sick, but with mono, they’ll often be big enough that you can actually see them sticking out of the sides your neck. They’ll be tender to the touch too, said Dr. Levine. “A classic sign of mono is having swollen lymph nodes on the back of the neck too, which you don’t typically see with other viruses.” - Shanna Levine, MD, Instructor, Medicine, General Internal Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.womenshealthmag.com/health/mono-symptoms

Health – February 1 The Truth About Scary Tamiflu Side Effects — Sarah Klein At least once every flu season, we hear a chilling story about someone who has experienced an abnormal or dangerous psychiatric event after taking the prescription antiviral flu medication Tamiflu. Tamiflu can be taken by anyone who has the flu. But its most recommended for people who are at the highest risk of developing serious complications – that means kids, older folks, and those whose immune systems are already weakened. That urgency sends some people clamoring to get their hands on a prescription before fully understanding Tamiflu’s drawbacks. “Any time you’re considering taking a drug, you have to consider whether the benefit you’re going to get from it is worth the risk,” said Nicole M. Bouvier, MD, associate professor of medicine, infectious diseases, and microbiology at the Icahn School of Medicine at Mount Sinai. “In most people, flu is definitely an unpleasant illness ... but you’ll get over it almost as fast as if you took Tamiflu. For the average healthy person, I think the potential risks are just not worth the benefits.” A wide range of strange behavior has been reported after taking Tamiflu, including dizziness, hallucinations, delirium, and even suicidal thoughts or behavior, mostly in kid. So far, science hasn’t been able to parse out what’s actually causing these events, Dr. Bouvier said. “You don’t really know whether it’s the drug that’s causing it, whether it has something to do with being infected with flu, or if it would have happened anyway without flu infection or treatment.” - Nicole M. Bouvier, MD, Associate Professor, Medicine, Infectious Diseases, Microbiology, Icahn School of Medicine at Mount Sinai Learn more: http://www.health.com/cold-flu-sinus/tamiflu-side-effects

Psychology Today – February 1 Five Myths About Depression We Need To Shut Down Immediately — Allison Abrams Depression, like art, can never be adequately described in words along. Though words can do some justice and art can convey an essence, unless one has endured the experience, the intangible nature of depression, like other invisible illnesses, makes it that much more challenging for sufferers and non-sufferers alike to reconcile. We often fear what we don’t understand, and both fear and lack of understanding breed fertile ground for stigma. We discuss and explain some common myths about depression. According to Harold W. Koenigsberg, MD, professor of psychiatry and director of the mood and personality disorders program at the Icahn School of Medicine at Mount Sinai, “In clinical depression, the bodily concomitants, such as low energy level, inability to activate pleasure circuitry, are fixed and cognitive patterns lose their flexibility. When this happens, it becomes hard to pull oneself out.” - Harold W. Koenigsberg, MD, Professor, Psychiatry, Director, Mood and Personality Disorders Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.psychologytoday.com/blog/nurturing-self-compassion/201802/5-myths-about-depression-we-need-shut- down-immediately

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - February 1, 2018 Date: Thursday, February 01, 2018 2:44:59 PM Attachments: ATT00001.txt

In the News February 1, 2018

Bloomberg Radio – January 31 Bloomberg Markets: Business Of HealthCare — Carol Massar and Cory Johnson Kenneth L. Davis, MD, president and CEO of the Mount Sinai Health System discusses the possibility of Amazon, JPMorgan, and Berkshire forming their own health care venture. The biggest problem with our rising healthcare costs is “too big of a percentage of GDP, we all don’t have a great idea of what to do about it. There is a sense that the system now rewards performance over quality. What we have is a fee- for-service system as opposed to a system in which you get paid a fixed amount that doesn’t change. In fact, what you might get are rewards if you have better outcomes, getting patients out of the hospitals and avoiding readmissions,” Dr. Davis said. Dr. Davis concluded that the first step in a smarter healthcare system is that, “We have to realign the system, manage care better, identify those patients who are the high consumers of care, navigate them, case manage them, prevent disease in those high utilizers as best we can. Mount Sinai has been able to successfully do that, I think this can be done at a much larger scale.” - Kenneth L. Davis, MD, President, CEO, Mount Sinai Health System Learn more: https://www.bloomberg.com/news/audio/2018-01-31/bloomberg-markets-fed-rate- unchanged-business-of-health-care

South Florida News Weekly Pulse – February 1 Mount Sinai Health System Expands Innovative Care In Florida — Charles Felix Mount Sinai Health System announced the opening of a new state-of-the-art medical practice in Palm Beach, Florida, bringing world-class innovative care to patients and businesses in the region. Mount Sinai Doctors Palm Beach, centrally located on North Flagler Drive in West Palm Beach, will offer primary care, cardiology, gastroenterology, and ophthalmology services. “This is a significant step in expanding the reach of Mount Sinai New York’s innovative high-quality care in South Florida,” said Kenneth L. Davis, MD, president and CEO of the Mount Sinai Health System. “Residents of Palm Beach County and patients who travel between Florida and New York now have streamlined access to care from Mount Sinai’s outstanding physicians in a broad array of specialties.” The compassionate and highly trained physician staff will be led by prominent cardiovascular specialist Gonzalo Loveday, MD, FACC, who will be the practice’s medical director. “The staff and clinical leadership at Mount Sinai Doctors Palm Beach have been carefully chosen from a large pool of national applicants and are dedicated to providing comprehensive, highest-quality care to their patients,” said Arthur Klein, MD, president of the Mount Sinai Health Network. “We are proud to provide the resources of our nationally and internationally recognized academic health care system to benefit the residents and businesses of Palm Beach County.” - Kenneth L. Davis, MD, President, CEO, Mount Sinai Health System - Gonzalo J. Loveday, MD, Assistant Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, Chief Medical Director, Mount Sinai Heart New York at Jupiter Medical Center, Medical Director, Mount Sinai Doctors Palm Beach - Arthur Klein, MD, President, Mount Sinai Health Network Learn more: http://www.sfhnhr.com/

Crain’s Health Pulse – February 1 Who’s News — Dan Goldberg Dr. Sandeep Kishore, associate director of The Arnhold Institute for Global Health, Icahn School of Medicine at Mount Sinai, has been named as a member of The National Academy of Medicine's (NAM's) first Emerging Leaders Forum. - Sandeep Kishore, MD, PhD, Associate Director, The Arnhold Institute for Global Health, Assistant Professor, Global Health, Medicine, Icahn School of Medicine at Mount Sinai Learn more: http://www.crainsnewyork.com/article/20180201/PULSE/180209999/white-adults-with- mental-illness-report-more-barriers-to-care-study Additional coverage: Politico New York https://www.politico.com/states/new-york/newsletters/politico-new-york-health- care/2018/02/01/cuomo-signs-laverns-law-029819

Medical Xpress – January 31 Machine Learning Techniques Generate Clinical Labels Of Medical Scans Researchers used machine learning techniques, including natural language processing algorithms, to identify clinical concepts in radiologist reports for CT scans, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published in the journal Radiology. The technology is an important first step in the development of artificial intelligence that could interpret scans and diagnose conditions. Researchers trained the computer software using 96,303 radiologist reports associated with head CT scans performed at The Mount Sinai Hospital and Mount Sinai Queens between 2010 and 2016. "The language used in radiology has a natural structure, which makes it amenable to machine learning," said senior author Eric Oermann, MD, instructor in the department of neurosurgery at the Icahn School of Medicine at Mount Sinai. "Machine learning models built upon massive radiological text datasets can facilitate the training of future artificial intelligence-based systems for analyzing radiological images." Study co-author, John Zech, a medical student at the Icahn School of Medicine at Mount Sinai said, “The ultimate goal is to create algorithms that help doctors accurately diagnose patients.” Joshua Bederson, MD, professor and system chair for the department of neurosurgery at the Mount Sinai Health System and clinical director of the neurosurgery simulation core as well as the study co-author, explained, “Research like this turns big data into useful data and is the critical first step in harnessing the power of artificial intelligence to help patients.” - Eric Oermann, MD, Instructor, Neurosurgery, Icahn School of Medicine at Mount Sinai - John Zech, Medical Student, Icahn School of Medicine at Mount Sinai - Joshua Bederson, MD, Professor, System Chair, Neurosurgery, Mount Sinai Health System, Clinical Director, Neurosurgery Simulation Core Learn more: https://medicalxpress.com/news/2018-01-machine-techniques-clinical-medical-scans.html Additional coverage: Healthcare Analytics News http://www.hcanews.com/news/at-mount-sinai-researchers-teach-machines- the-language-of-radiology Research & Development https://www.rdmag.com/news/2018/02/machine-learning-techniques-generate- clinical-labels-medical-scans Science Newsline http://www.sciencenewsline.com/news/2018013121570068.html Imaging Technology News https://www.itnonline.com/content/machine-learning-techniques-generate- clinical-labels-medical-scans

News Medical & Life Sciences – January 31 Mount Sinai Study Uncovers Potential Link Between Poor Diet And Back Injuries In a first-of-its-kind study, Mount Sinai researchers have found a possible link between a poor diet and back injuries, especially in women. The study suggests that following a specific type of diet that excludes fast foods and highly processed foods could decrease vertebral fractures and prevent bone loss as people age. Scientists from the Leni & Peter W. May Department of Orthopaedics at the Icahn School of Medicine at Mount Sinai examined the effect of a diet high in advanced glycation endproducts (AGEs) on the spine, something that has never been done before. The research findings are set to be published in the February issue of the Journal of Bone and Mineral Research. “This study is particularly important since it focuses attention on the importance of nutrition in promoting spinal health and susceptibility to injury, expanding our thinking beyond genetics and mechanical injuries. By highlighting new ways of thinking about spine physiology, these studies can help identify innovative interventions," said lead researcher James Iatridis, PhD, professor and vice chair for research at the Leni and Peter W. May department of orthopaedics at the Icahn School of Medicine at Mount Sinai. "While novel innovations in therapies will take time to develop, these studies immediately let patients and doctors know that a healthy diet is important to maintaining a healthy spine." Svenja Illien-Junger, PhD, assistant professor of orthopaedics at the Icahn School of Medicine at Mount Sinai explained, “In addition to improved diets, a better understanding of what could lead to back pain and spine disease can help clinicians and researchers develop novel treatments." - James Iatridis, PhD, Professor, Vice Chair, Research, Leni and Peter W. May Department of Orthopaedics, Icahn School of Medicine at Mount Sinai - Svenja Illien-Junger, PhD, Assistant Professor, Orthopaedics, Icahn School of Medicine at Mount Sinai Learn more: https://www.news-medical.net/news/20180131/Mount-Sinai-study-uncovers-potential-link- between-poor-diet-and-back-injuries.aspx Additional coverage: Becker’s Spine Review https://www.beckersspine.com/spine/item/39730-mount-sinai-investigates-how-a- diet-impacts-back-problems-4-insights.html

Medical Xpress – February 1 Whites With Mental Illness Far More Likely To Report Insufficient Money For Care White adults with mental illness were significantly more likely than those of other ethnicities to report having insufficient money for mental health care or facing delays in care, a Mount Sinai study found. Whites were 50 percent more likely than blacks to experience delays in care, and 20 percent more likely than blacks to lack enough money for treatments such as doctor visits and prescription drugs, the researchers found. The results of the study will be published online in Psychiatric Services, a journal of the American Psychiatric Association. "The results of our research are surprising in light of numerous studies demonstrating disparities in health care utilization among adults in racial and ethnic minority groups," said the study's lead author, Judith Weissman, PhD, JD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai. "Black and Hispanic adults have historically fared worse than white adults, who disproportionately use private coverage. Our study revealed that health coverage and access for the mentally ill can be jeopardized by an economic recession if it is tied to private coverage through employment." The research introduces the possibility that limited access to health care may contribute to the current reported increase in poor health outcomes in white middle-aged adults. The study's senior author is Dolores Malaspina, MD, MPH, director of the psychosis program in the department of psychiatry at the Icahn School of Medicine at Mount Sinai. The results suggest that access to care was worse for patients living in states that were less likely to expand Medicaid access under the Affordable Care Act. - Judith Weissman, PhD, JD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai - Dolores Malaspina, MD, MPH, Director, Psychosis Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://medicalxpress.com/news/2018-02-whites-mental-illness-insufficient-money.html Additional coverage: Crain’s Health Pulse http://www.crainsnewyork.com/article/20180201/PULSE/180209999/white-adults- with-mental-illness-report-more-barriers-to-care-study Health Medicine Network http://healthmedicinet.com/whites-with-mental-illness-far-more-likely-to- report-insufficient-money-for-care-delays/

Science Daily – January 31 Falling IQ Scores In Childhood May Signal Psychotic Disorders Later In Life New research shows adults who develop psychotic disorders experience declines in IQ during childhood and adolescence, falling progressively further behind their peers across a range of cognitive abilities. The researchers from King’s College London’s Institute of Psychiatry, Psychology, and Neuroscience and the Icahn School of Medicine at Mount Sinai, found falls in IQ start in early childhood, and suggest educational interventions could potentially delay the onset of mental illness. IQ scores fluctuate among healthy individuals, and not all children struggling at school are at risk of developing serious psychiatric disorders. Senior author, Abraham Reichenberg, PhD, professor of psychiatry, environmental medicine and public health at the Icahn School of Medicine at Mount Sinai said, “It is important to bear in mind that many children will experience some difficulties with schoolwork or other intellectual tasks at some point in their lives, and only a small minority will go on to develop a psychotic disorder.” He explained, “Our results show the potential importance of interventions happening much earlier in life. Intervening in childhood or early adolescence may prevent cognitive abilities from worsening and this may even delay or prevent illness onset.” - Abraham Reichenberg, PhD, Professor, Psychiatry, Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai Learn more: https://www.sciencedaily.com/releases/2018/01/180131133348.htm Additional coverage: Medical Xpress https://medicalxpress.com/news/2018-01-falling-iq-scores-childhood-psychotic.html Daily Mail http://www.dailymail.co.uk/health/article-5335475/Falling-school-linked-psychotic- disorders.html Science Newsline http://www.sciencenewsline.com/news/2018013121570042.html News Reality http://www.newsreality.com/post/falling-behind-at-school-is-linked-to-psychotic- disorders.html

Psychiatric Times – January 31 Tools And Tips For Assessing Cognition In Older Adults: Issues For Psychiatrists— Priya Sharma, MD and Melinda Lantz, MD With the growth of the elderly population has come increased pressure on psychiatrists to offer timely access to quality care that is specific to the needs of the elderly, particularly the recognition of cognitive loss and dementia. Priya Sharma, MD, geriatric psychiatry fellow in the department of psychiatry at Mount Sinai Beth Israel and Melinda Lantz, MD, associate professor of psychiatry at the Icahn School of Medicine at Mount Sinai, said that cognitive impairment is not always associated with dementia. For this reason, a full comprehensive history is an integral component of any cognitive assessment. Presenting complaints of memory loss or changes in behavior, demeanor, or activity in the elderly population may be reflective of a psychiatric illness including a mood or anxiety disorder, a response to a new medication or a change of dosing, or an underlying medical condition. The following Case Vignette illustrates how complex presenting memory loss can be when complicated by both medical and psychiatric comorbidities. - Priya Sharma, MD, Geriatric Psychiatry Fellow, Department of Psychiatry, Mount Sinai Beth Israel - Melinda Lantz, MD, Associate Professor, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: http://www.psychiatrictimes.com/article/tools-and-tips-assessing-cognition-older-adults- issues-psychiatrists

The Scientist – January 31 Viruses Related To Zika May Also Harm Fetuses— Ruth Williams A Zika virus infection during pregnancy puts the fetus at risk of developing birth defects. Now, a new study suggests Zika may not be alone in harming babies. West Nile virus, Powassan virus, both flavivirus cousins of Zika, can infect and damage fetuses in pregnant mice and replicate efficiently in maternal and fetal tissues from humans, researches reported in Science Translational Medicine. “Basically they found that these related viruses were able to cross the placenta and infect the developing fetus,” said Jean K. Lim, assistant professor of microbiology at the Icahn School of Medicine at Mount Sinai. “The study is provocative because it highlights the need to evaluate how other flaviviruses, such as West Nile, may affect the baby.” The team went on to examine how the viruses behaved in mid-gestational placental tissue samples from human donors. They found that while Powassan and West Nile virus replicated readily in all samples, the alphaviruses exhibited inconsistent and less abundant replication. “These findings are interesting because they suggest Zika may not be unique,” said Dr. Lim. In particular, “West Nile virus, which is the most important pathogen for the United States, could negatively impact the developing fetus in a very small subset of pregnant women.” - Jean K. Lim, PhD, Assistant Professor, Microbiology, Icahn School of Medicine at Mount Sinai Learn more: https://www.the-scientist.com/?articles.view/articleNo/51524/title/Viruses-Related-to-Zika- May-Also-Harm-Fetuses/

ABC World News Tonight – January 31 Flu Straining Resources — Linsey Davis New concerns over the deadly flu epidemic have risen as doctors in the northeast say those rapid flu tests that help diagnose the virus quickly are now in short supply. Judah Fierstein, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and medical director of Mount Sinai Doctors Urgent Care said, “Most urgent care centers don’t have the rapid flu test and the major suppliers can’t provide them right now.” - Judah Fierstein, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Mount Sinai Doctors Urgent Care Learn more: http://abc.go.com/shows/world-news-tonight/episode-guide/2018-01/31-013118-trumps-talk- of-immigration-reform-in-state-of-the-union-falls-flat-with-democrats

Reader’s Digest – January 31 Five Types Of Heart Disease And Their Warning Signs — Alyssa Jung Heart disease is the number one cause of death in the United States. Clogged arteries often lead to coronary artery disease, which accounts for one in seven deaths in the U.S. each year, according to the American Heart Association. Plaque buildup in the main blood vessels of the heart stymie blood flow to the muscle. “This is the number one type of heart disease that we take care of,” said Sandhya K. Balaram, MD, PhD, associate professor of cardiovascular surgery at the Icahn School of Medicine at Mount Sinai. Since arteries clog over time due to a variety of risk factors – high blood pressure, high cholesterol, diabetes, or a sedentary lifestyle – many patients don’t notice any symptoms until there’s a significant blockage. Symptoms include shortness of breath, chest pain, or even heart attack. These are silent signs of a heart attack. The heart is made up of four main valves, which open and close like doors to control blood flow. They're usually soft like tissue paper, said Dr. Balaram, but when they become calcified (hard deposits of calcium accumulate) they become stiff and narrow, reducing blood flow. - Sandhya K. Balaram, MD, PhD, Associate Professor, Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.rd.com/health/conditions/types-of-heart-disease/

Everyday Health – January 31 What’s The Difference Between Acid Reflux And GERD? — Denise Schipani A burning pain in your chest generally signals heartburn, right? But if you were thinking that heartburn, also known as acid reflux, is the same as gastroesophageal reflux disease (GERD), read this. While it may seem that GERD is just a fancy name for heartburn, they are more like close cousins than identical twins. According to the American College of Gastroenterology, GERD is acid reflux that occurs more than a couple of times per week. That said, it’s not the case that a person who has occasional heartburn will necessarily progress toward having GERD, said Louis Cohen, MD, assistant professor of medicine and gastroenterology at the Icahn School of Medicine at Mount Sinai. But the symptoms are the same as those of acid reflux, such as the burning feeling in your chest and the sensation that your stomach contents are in your throat. Diagnosing the condition can usually be done by a primary care doctor or gastroenterologist, by simply evaluating symptom frequency and severity. “We may also put a probe into a patient’s esophagus for a day to measure how frequently reflux happens,” said Dr. Cohen. Knowing how often reflux occurs is another way to confirm diagnosis. - Louis Cohen, MD, Assistant Professor, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai Learn more: https://www.everydayhealth.com/gerd/symptoms/whats-difference-between-acid-reflux- gerd/

Romper – January 31 Can You Get The Flu Twice? Here’s What Experts Want You To Know — Candance Ganger This year’s flu season has officially reached epidemic proportions. With four different strains going around at any given time, you might have a better chance winning the lottery than not catching a virus. So, if you’ve already been sick once this season, can you get the flu twice? The answer, unfortunately, is a resounding yes. Nicole M. Bouvier, MD, associate professor of medicine, infectious diseases, and microbiology at the Icahn School of Medicine at Mount Sinai said, if you’ve already had one strain of the flu, it doesn’t necessarily mean you’re automatically immune to any other strain currently circulating. That’s because “different strains are different viruses – and they’re not neutralized by the same antibodies.” Dr. Bouvier goes on to say that while the current number of flu cases is a bit concerning, it’s not completely out of the ordinary either. In fact, the nation saw similar stats from the 2014-2015 season which was a more difficult flu season than some of the previous ones we’ve all endured. - Nicole M. Bouvier, MD, Associate Professor, Medicine, Infectious Diseases, Microbiology, Icahn School of Medicine at Mount Sinai Learn more: https://www.romper.com/p/can-you-get-the-flu-twice-heres-what-experts-want-you-to- know-8005021

Women’s Health Magazine – January 31 Your Favorite Relaxation Habit Might Be Secretly Screwing With Your Meds— Ashley Mateo As medical marijuana use continues to rise, the use might actually be messing with some other medications you may take. “There are literally hundreds of chemicals in the cannabis plant, including the psychoactive chemicals that give us a traditional marijuana high and chemicals that just happen to be in the plant,” said Timothy Brennan, MD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai and director of the fellowship in addiction medicine program at the addiction institute for Mount Sinai West. “All of those, of course, are free to interact with prescription, over-the-counter, or any other medications one might be using.” In fact, some of the compounds in cannabis can trigger certain enzymes that impact the way your body processes medications, Dr. Brennan explained. “The key point here is that cannabis is fundamentally a psychoactive compound. People use it because it exerts its action on the brain, and on the central nervous system receptors.” You might think that allergy and cold medicine are no big deal, because you can grab them straight off the drugstore shelves – but if you take them with marijuana, they could have unanticipated effects. - Timothy Brennan, MD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Director, Fellowship in Addiction Medicine Program, Addiction Institute, Mount Sinai West Learn more: https://www.womenshealthmag.com/health/marijuana-drug-interactions

New York Daily News – January 31 ‘Grey’s Anatomy’ Recruits Trans Actress Candis Cayne For ‘Groundbreaking’ Gender Assignment Surgery Storyline— Ariel Scotti “Grey’s Anatomy” will continue to highlight transgender stories this season with the addition of actress Candis Cayne in the multi-episode role. Cayne will play a patient admitted to the fictional Grey Sloan Memorial Hospital for a “groundbreaking” vaginoplasty surgery. Cayne’s character was inspired by a real-life story of a transgender woman who helped Jess Ting, MD, surgical director of Mount Sinai’s Center for Transgender Medicine and Surgery, create a new method for her reassignment procedure. The surgery revolutionizes the making of a vagina. “We thought that was a really cool story and Candis is playing a character inspired by something we read,” said Grey’s showrunner Krista Vernoff. - Jess Ting, MD, Surgical Director, Mount Sinai’s Center for Transgender Medicine and Surgery, Assistant Professor, Plastic and Reconstructive Surgery, Icahn School of Medicine at Mount Sinai Learn more: http://www.nydailynews.com/entertainment/tv/grey-anatomy-recruits-actress-candis-cayne- trans-plotline-article-1.3791226 Additional coverage: Hollywood Reporter https://www.hollywoodreporter.com/live-feed/greys-anatomy-enlists-candis-cayne- groundbreaking-trans-story-1080321 The Inquisitr https://www.inquisitr.com/4765151/greys-anatomy-books-candis-cayne-for-a- groundbreaking-gender-reassignment-storyline/ Heavy https://heavy.com/entertainment/2018/01/candis-cayne-greys-anatomy-transgender-actress/ Bustle https://www.bustle.com/p/candis-caynes-greys-anatomy-trans-storyline-is-breaking-new-ground- for-the-abc-series-8079696 United Press International https://www.upi.com/Entertainment_News/TV/2018/01/31/Greys-Anatomy- Candis-Cayne-to-guest-star-in-Season-14/9381517422737/

Cosmopolitan – January 31 This Couple Was Diagnosed With Foot Worms After A Beach Trip — Elizabeth Narins When a couple returned from a weeklong trip to Punta Cana and the Dominican Republic, they couldn’t ignore their itchy feet. Although the couple first assumed bug bites were to blame, they were diagnosed with a parasitic infection days later. Swollen feet led the couple to visit the hospital several times, but it wasn’t until the end of the month that they were diagnosed. It took three doctors to identify the infections as cutaneous larva migrans, which is caused when baby hookworms penetrate unbroken skin and burrow in, according to Daniel Caplivski, MD, associate professor of medicine, infectious disease, and director of the travel medicine program at the Icahn School of Medicine at Mount Sinai. The itching is caused by inflammation that trails the microscopic worm, which can also cause redness and blisters as it moves to different parts of the foot. Although Dr. Caplivski didn’t treat the patients, he said the larva spread in cat and dog feces are often present in sand where these animals are present. Dr. Caplivski said an easy way to side step this infection, is to wear protective footwear on beaches where stray animals and pets roam, and to lie on a towel rather than directly on the sand, since all bare skin is susceptible to the infection. - Daniel S. Caplivski, MD, Associate Professor, Medicine, Infectious Diseases, Director, Travel Medicine Program, Icahn School of Medicine at Mount Sinai Learn more: http://www.cosmopolitan.com/health-fitness/a15923310/foot-worms-beach/

The Washington Post – January 31 After John Wall’s Surgery, Doctors Provide A Glimpse Of What His Recovery Could Look Like – Candice Buckner The fate of John Wall’s left knee deserves its own chapter in the story of this Washington Wizards season. According to experts in the field of orthopedic surgery and physical therapy, Wall, underwent a minimally invasive procedure in which nothing was sewn together. He should immediately be able to conduct everyday actions. “The good thing is you can walk on it right away, you can do low-impact activities right away,” said Alexis Colvin, MD, associate professor of sports medicine and orthopaedics at the Icahn School of Medicine at Mount Sinai, who has not worked with Wall but agreed to provide context on his procedure. “But everything is a step-by-step progression, so of course you’re not going to play a high-impact sport right away. You have to build up to that point.” - Alexis Colvin, MD, Associate Professor, Sports Medicine, Orthopaedics, Icahn School of Medicine at Mount Sinai, Chief Medical Officer, United States Tennis Association Learn more: https://www.washingtonpost.com/news/wizards-insider/wp/2018/01/31/after-john-walls- surgery-doctors-provide-a-glimpse-of-what-his-recovery-could-look-like/?utm_term=.836dc24afa2d

New York Daily News – January 31 Pelicans All-Star Cousins Has Surgery On Achilles Tendon The New Orleans Pelicans says front-court All-Star DeMarcus Cousins has had surgery to repair his ruptured left Achilles tendon. The Pelicans have said Cousins will miss the remainder of this season but no timeline has been announced for the 27 year old. Steven Weinfeld, MD, associate professor of orthopaedics at the Icahn School of Medicine at Mount Sinai and chief of foot and ankles surgery for the Mount Sinai Hospital, said basketball players with the same injury Cousins had usually need nearly a year of rehabilitation before playing again, and routinely up to two years before returning to peak physical performance. - Steven Weinfeld, MD, Associate Professor, Orthopaedics, Icahn School of Medicine at Mount Sinai, Chief, Foot and Ankle Surgery, The Mount Sinai Hospital Learn more: http://www.nydailynews.com/newswires/sports/pelicans-all-star-cousins-surgery-achilles- tendon-article-1.3791797 Additional coverage: AP News https://apnews.com/436cc43ba2bf458480a97480f0676202/Pelicans-All-Star-Cousins-has-surgery- on-Achilles-tendon Chicago Daily Herald http://www.dailyherald.com/article/20180131/sports/301319788/ The Washington Post https://www.washingtonpost.com/sports/wizards/pelicans-all-star-cousins-has- surgery-on-achilles-tendon/2018/01/31/cf2a3b40-06e5-11e8-aa61-f3391373867e_story.html? utm_term=.b3d2dd7c84f1 USA Today https://www.usatoday.com/story/sports/nba/2018/01/31/pelicans-all-star-cousins-has- surgery-on-achilles-tendon/109992478/ ESPN http://www.espn.com/nba/story/_/id/22278987/new-orleans-pelicans-demarcus-cousins-surgery- achilles-tendon NBA http://www.nba.com/article/2018/01/31/new-orleans-pelicans-all-star-demarcus-cousins-has- surgery-achilles-tendon/#/ Fox Sports https://www.foxsports.com/nba/story/pelicans-all-star-cousins-has-surgery-on-achilles- tendon-013118

Nylon – January 31 Why You Should be Wearing A Gel Moisturizer This Winter — Taylor Bryant Gel moisturizers are typically categorized as being a summer skin-care product. It’s a reflex for most of us to reach for a heavy-duty moisturizer once the slightest of chills starts to creep into the air. This is based on the assumption that the creamier the moisturizer, the better chance you have of reaching a high level of hydration. There’s a common misconception that gel products are less moisturizing than their creamy counterparts. That’s not true, said Melissa K. Levin, MD, clinical instructor of dermatology at the Icahn School of Medicine at Mount Sinai. “Rather, gels use water as a medium to deliver ingredients while containing little oil; they also lack a high concentration of synthetic oils, which can clog pores,” she said. You can still get moisture without the greasy feeling that comes along with heavy-duty creams. “Previously, gel moisturizers were commonly alcohol-based and, therefore, could strip natural oils from the skin, making them suitable for only oily and acne-prone skin types,” she explained. “Cosmetic chemists have reformulated gel moisturizers to be highly packed with hydration but still lightweight.” - Melissa K. Levin, MD, Clinical Instructor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://nylon.com/articles/gel-moisturizer-winter

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - February 6, 2018 Date: Tuesday, February 06, 2018 2:27:56 PM Attachments: ATT00001.txt

In the News February 6, 2018

AAMC News – February 6 House Call Medicine Makes A Comeback — Robin Warshaw The old-time practice of doctors making house calls to see patients with acute illnesses is making a comeback for a different purpose: to provide on-going primary care to certain patients. Home-based primary care programs, many of which are run by academic medical centers, are gaining increasing interest nationwide as a way to bring comprehensive care to patients who are homebound with severe chronic conditions. “The number of homebound patients is larger than our nursing home population,” said study lead author, Katherine Ornstein, PhD, MPH, assistant professor of and palliative medicine at the Icahn School of Medicine at Mount Sinai. An additional one million patients are home- limited, going out sometimes but only with assistance, Dr. Ornstein adds. “The experience of seeing patients at home is substantially different than in a clinical setting. And seeing that world is really eye- opening.” Some programs are training for the future. Mount Sinai Visiting Doctors teaches house call medicine to a wide range of learners, from third-year medical students, residents, and fellows to nurse practitioner trainees and social work interns. - Katherine Ornstein, PhD, MPH, Assistant Professor, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://news.aamc.org/patient-care/article/house-calls-make-comeback/

Science Newsline – February 5 Popular, Common Allergy Medication May Prevent Neuromyelitis Optica Relapses The addition of cetirizine (the popular allergy medication sold under the brand name Zyrtec) to standard therapy is safe, well-tolerated, and may reduce relapses in patients with neuromyelitis optica (NMO), a rare and severe disease that causes inflammation and demyelination (damage to the myelin - the protective coating of nerve cells), primarily in the optic nerve (optic neuritis), spinal cord (myelitis), and brainstem. "We were pleased to find that cetirizine was safe and well-tolerated in our population of NMO patients. While the study's open-label design and small sample size preclude definitive conclusions, we did detect a signal that suggested cetirizine may be of benefit. We look forward to future research on this topic,” said Ilana Katz Sand, MD, assistant professor of neurology at the Icahn School of Medicine at Mount Sinai. - Ilana Katz Sand, MD, Assistant Professor, Neurology, Icahn School of Medicine at Mount Sinai Learn more: http://www.sciencenewsline.com/news/2018020516480062.html

Physician’s Briefing – February 5 Mental Health Care Access Differs With Race, Insurance Among adults with serious psychological distress, whites and those with private insurance were significantly more likely than blacks to experience certain barriers to utilizing health care, according to a study published in Psychiatric Services. Judith Weissman, PhD, JD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai, and colleagues used data from the National Health Interview Survey to compare health care access and utilization among adults with serious psychological distress by race-ethnicity and gender in years surrounding implementation of the Affordable Care Act. "More research is needed on health care utilization among adults with serious psychological distress," the authors write. "In this group, whites and those with private coverage reported poor utilization, compared with other racial-ethnic groups and those with Medicaid, respectively.” - Judith Weissman, PhD, JD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: http://www.physiciansbriefing.com/Article.asp?AID=730656 Additional coverage: Doctors Lounge https://www.doctorslounge.com/index.php/news/pb/78245

NewsGram – February 6 Eat Grapes To Ward Off Depression Including grapes in your diet may have a positive impact on your mental health as researchers have found that certain grape-derived compounds might be developed as therapeutic agents for the treatment of depression. “The discovery of these new, natural grape-derived polyphenol compounds targeting cellular and molecular pathways associated with inflammation may provide an effective way to treat a subset of people with depression and anxiety, a condition that affects so many people,” said lead researcher Giulio Maria Pasinetti, PhD, MD, Saunders professor of neurology and program director for the center for molecular integrative neuroresilience at the Icahn School of Medicine at Mount Sinai. The new study found that a bioactive dietary polyphenol preparation from grape was effective in promoting resilience against stress-induced depression in mice. “Our research shows that combination treatment with the two compounds can promote resilience against stress-mediated depression-like phenotypes by modulating systemic inflammatory responses and brain synaptic plasticity in a mouse model of depression,” said Jun Wang, PhD, associate professor of neurology at the Icahn School of Medicine at Mount Sinai. - Giulio Maria Pasinetti, PhD, MD, Saunders Professor, Neurology, Program Director, Center for Molecular Integrative Neuroresilience, Icahn School of Medicine at Mount Sinai - Jun Wang, PhD, Associate Professor, Neurology, Icahn School of Medicine at Mount Sinai Learn more: https://www.newsgram.com/eat-grapes-to-ward-off-depression/ Additional coverage: Medical News Today https://www.medicalnewstoday.com/articles/320830.php FreshPlaza http://www.freshplaza.com/article/189102/Eating-grapes-can-ward-off-depression,-according- to-study Science Newsline http://www.sciencenewsline.com/news/2018020516480063.html

HealthCare Business Daily News – February 6 Mount Sinai Researchers Train Machine Learning Tool To Understand Radiology Reports — Lauren Dubinsky Eric Oermann, MD, instructor of neurosurgery at the Icahn School of Medicine at Mount Sinai, believes that the future of radiology will involve artificial neural networks that assist physicians in performing daily tasks such as interpreting imaging. He and his team are using machine learning techniques including natural language processing algorithms to identify clinical concepts in radiology reports for CT scans. His research team is what makes this tool different from the others. Many of the team members are practicing physicians and medical students who are competent machine learning researchers. The team found that the techniques used in this study resulted in a 91 percent accuracy rate. That demonstrates that it is possible to automatically identify concepts in text from the complex domain of radiology. When asked whether machine learning techniques are something any hospital and radiology practice will have the financial means to deploy, Dr. Oermann replied that algorithms are generally cheaper to deploy than most things in health care. - Eric Oermann, MD, Instructor, Neurosurgery, Icahn School of Medicine at Mount Sinai - John Zech, Medical Student, Icahn School of Medicine at Mount Sinai - Joshua Bederson, MD, Professor, System Chair, Neurosurgery, Mount Sinai Health System, Clinical Director, Neurosurgery Simulation Core Learn more: https://www.dotmed.com/news/story/41420 Additional coverage: GlobalSpec http://insights.globalspec.com/article/7884/using-ai-to-diagnose-disease Health Imaging http://www.healthimaging.com/topics/artificial-intelligence/ai-almost-perfectly- interprets-radiology-reports

NBC Nightly News – February 5 Flu Emergency: The Risk Of Getting The Flu Twice This Season — Dr. John Torres Doctors are warning that just because you had the flu once this season, does not mean you can’t get it again. There are at least four types of flu strains circulating, classified as Type A – which is the predominant and most severe – and Type B. So even if you get sick with one, you can still get infected from other strains. Nicole M. Bouvier, MD, associate professor of medicine, infectious diseases, and microbiology at the Icahn School of Medicine at Mount Sinai said, “Once you’ve gotten one strain of the flu, you are protected from getting that exact strain again. After a while, once your immune response slows down a little bit, you are still susceptible to catching one of the other three strains.” - Nicole M. Bouvier, MD, Associate Professor, Medicine, Infectious Diseases, Microbiology, Icahn School of Medicine at Mount Sinai Learn more: https://www.nbc.com/nightly-news/video/nbc-nightly-news-feb-5-2018/3657971

ABC News – February 6 Washing Hands Versus Hand Sanitizer In Fighting The Flu One of the best ways to protect yourself against the flu is to clean your hands. So what works best, washing them or using hand sanitizer? With the worst flu on record in at least a decade and 53 child deaths across the country, experts are zeroing in on simply hygiene saying it can help curb the spread of the virus. “Frequent hand washing – not just, ‘Kids, wash your hands before dinner,’ – but wash your hands frequently during the day from touching things,” said Peter Shearer, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and medical director of the emergency department of the Mount Sinai Hospital. Hand washing and hand sanitizer are both ways to fight flu. When it comes to hand sanitizer, alcohol-based products work so much better because the alcohol breaks up the bacteria’s proteins and kills them. - Peter Shearer, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Emergency Department, The Mount Sinai Hospital Learn more: http://wtnh.com/2018/02/06/washing-hands-vs-hand-sanitizer-in-fighting-the-flu/

Healio – February 5 Diabetes Epidemic Spurs Renewed Focus, Creative Solutions For U.S. Endocrinologist Shortage — Regina Schaffer As the prevalence of diabetes in the U.S. continues to grow, so too does the need for qualified clinical endocrinologists to meet patient demand. In 2015, an estimated 1.5 million new cases of diabetes were diagnosed among adults, according to the CDC. “Managing diabetes may sound simple, but it is complicated,” said Andrew Stewart, MD, director of the diabetes, obesity, and metabolism institute at the Icahn School of Medicine at Mount Sinai. “There are more and more new drugs and sets of guidelines — even conflicting guidelines — on optimal diabetes management. Drug after drug comes out: This one has cardiovascular benefit, this one doesn’t, this one might. The details are complicated, and there is no question that there is a need for more endocrinologists.” Dr. Stewart added that a lot of good things are happening. “The fun part about my job is that you get to see these amazing things happening. The hard part is getting it translated to the 30 million or potentially 100 million people who actually need it.” - Andrew Stewart, MD, Director of the Diabetes, Obesity, and Metabolism Institute at the Icahn School of Medicine Learn more: https://www.healio.com/endocrinology/practice-management/news/print/endocrine- today/%7Bc4390176-2692-4ea9-abee-e75234e8cfbc%7D/diabetes-epidemic-spurs-renewed-focus-creative- solutions-for-us-endocrinologist-shortage

UNTV News – February 6 Cigarette Smoking During Pregnancy Linked To ADHD In Offspring Children born to women who smoke cigarettes during pregnancy, especially when mothers are heavy smokers, are at an increased risk for attention-deficit/hyperactivity disorder (ADHD), a new review of medical studies confirms. The team found lower risks for ADHD in children of mothers who smoked in the U.S. and Europe, where more smokers stop smoking when they get pregnant. “It would be a big leap from that, but if you are a prior smoker and stop during pregnancy, the inference is that the risk of ADHD goes down,” said Jeffrey Newcorn, MD, professor of psychiatry, pediatrics, and director of the division of ADHD, learning disabilities and related disorders at the Icahn School of Medicine at Mount Sinai. Dr. Newcorn, who was not involved in the research, would like to see more studies on the relationship between genetic and environmental factors in developing ADHD, as well as the role of nicotine exposure. - Jeffrey Newcorn, MD, Professor, Psychiatry, Pediatrics, Director, Division of ADHD, Learning Disabilities and Related Disorders, Icahn School of Medicine at Mount Sinai Learn more: https://www.untvweb.com/news/just-one-cigarette-day-can-lead-heart-disease/

The Conversation – February 6 Why Heart Disease Is Often Missed In Women: The Myth Of The ‘Widowmaker’ — Scott Lear Heart disease is the number one cause of death for women throughout the world. Approximately seven times more women will die from heart disease than breast cancer. A 2012 survey from the United States found that only 56 percent of female respondents identified heart disease as the leading cause of death. Upon arrival in the hospital, women’s symptoms can be dismissed by medical professionals as something else. A reason is that research has historically conducted in middle-aged and older men. This is, in part, because men had heart attacks during their working years, potentially limiting their economic productivity. Women – who tended to suffer heart disease at a later age – received less attention. There was also a fear of involving pregnant women in research, which led to all women of child-bearing age being restricted from participating in most research in the U.S. until the 1990s. As a result, people both within and outside of the medical profession had the impression that heart disease is for men. Annapoorna S. Kini, MD, professor of cardiology and medicine at the Icahn School of Medicine at Mount Sinai, reviews a patient’s angiogram before beginning a procedure at The Mount Sinai Hospital. - Annapoorna S. Kini, MD, Professor, Cardiology, Medicine, Icahn School of Medicine at Mount Sinai Learn more: http://theconversation.com/why-heart-disease-is-often-missed-in-women-the-myth-of-the- widowmaker-90530

Runner’s World – February 6 Six Warning Signs Of Stomach Cancer — Markham Heid Stomach cancer has a reputation for being one of the most painful forms of cancer. But for many sufferers, pain is not among the disease’s early warning signs. In fact, the most common feature in the early stages may be that it causes no symptoms at all, said Umut Sarpel, MD, associate professor of surgery at the Icahn School of Medicine at Mount Sinai. “We all get stomachaches from time to time and that can make people worry about stomach cancer,” Dr. Sarpel said. “But it’s not one of the most common cancers, and in most cases, stomachaches or pain is not going to be the result of cancer.” Roughly one in 111 adults will develop stomach cancer at some point in their lifetime, and the disease is more common among men, according to the American Cancer Society. Dr. Sarpel adds that a person’s risk for the disease goes up as she ages. Stomach cancer is not typically an inherited disease. “The majority of gastric cancers are sporadic, or cause by random DNA mutations,” she said. While there is a super-rare genetic mutation associated with the disease, Dr. Sarpel said it’s not worth testing for that unless a lot of people in your family tree have had the disease. - Umut Sarpel, MD, Associate Professor, Surgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.runnersworld.com/health/6-warning-signs-of-stomach-cancer

Allergic Living – February 6 Food Allergies: Hot Tips For Kissing Safely — Gina Clowes According to Scott Sicherer, MD, professor of pediatrics, allergy and immunology and chief of the division of allergy and immunology at the Jaffe Food Allergy Institute at the Icahn School of Medicine at Mount Sinai, studies show that between five and 12 percent of food-allergic individuals will experience a reaction from kissing. Our saliva contains food protein after we eat. In some cases, that residual protein can linger, even after chewing gum or brushing teeth. Researchers from the Icahn School of Medicine at Mount Sinai studied the risk of peanut exposure from the saliva of a partner who had eaten peanut butter. They found that no detectible peanut protein was left almost four hours later and after the partner had eaten a peanut-free meal. This suggests that if an allergen was eaten, you’re best to wait several hours before any contact, and have the date eat something. - Scott Sicherer, MD, Professor, Pediatrics, Allergy and Immunology, Chief, Division of Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.allergicliving.com/2018/02/06/food-allergies-hot-tips-for-kissing-safely/

Self Magazine – February 4 Why Do My Ear Buds Always Fall Out? — Amber Brenza Unlike your headphones, ears don’t really come as one-size-fits-all, which is why your earbuds might not fit sometimes. Earbuds are supposed to fit so that their little speakers are snug inside the ear canal, allowing sound waves to hit the eardrum more directly. Everyone’s ears and ear canals are different sizes and shapes, so even if those one-size-fits-all earbuds are made according to “standard” ears, they aren’t going to fit every person perfectly. “Children generally have small ear canals, and most men generally have larger ear canals than women,” said Randi Tepper, AuD, senior pediatric audiologist at the New York Eye and Ear Infirmary of Mount Sinai. Beyond that, it just depends, and this is where you can run into earbud problems. Even if your ear canals are of typical size, a buildup of earwax could cause ill- fitting earbuds. “Sometime people come to me and there’s a ton of wax against the eardrum, and there’s no way for wax to get pushed in like that unless it’s by an earbud or a Q-tip,” said Maura Cosetti, MD, director of the Cochlear Implant Center at the Ear Institute of the New York Eye and Ear Infirmary of Mount Sinai. Ear wax is your body’s natural mechanism for keeping your ears clean, and you shouldn’t use Q-tips to try to remove that wax because it can just push the wax in deeper. - Randi Tepper, AuD, Senior Pediatric Audiologist, New York Eye and Ear Infirmary of Mount Sinai - Maura K. Cosetti, MD, Assistant Professor, Otolaryngology, Neurosurgery, Icahn School of Medicine at Mount Sinai, Director, The Cochlear Implant Center, Ear Institute, New York Eye and Ear Infirmary of Mount Sinai Learn more: https://www.self.com/story/earbuds-always-fall-out

Michigan Mom Living – February 5 New Survey Focused On How People Living With Ulcerative Colitis May Be Impacted In Their Daily Life — Cynthia Tait For patients who suffer from chronic disease, like ulcerative colitis (UC), an inflammatory bowel disease characterized by chronic diarrhea, abdominal pain and cramping, embracing and maintaining a social life can be challenging. While the disease can occur at any age, it most often starts under the age of 30, and the symptoms can be debilitating. For some people, UC and its symptoms may not be easy to talk about in any relationship, especially if you are meeting someone new. Marla Dubinsky, professor of pediatrics and gastroenterology at the Icahn School of Medicine at Mount Sinai and chief of pediatric gastroenterology and hepatology at the Kravis Children’s Hospital at Mount Sinai shares some of the ins and outs of living with ulcerative colitis and also discusses the preliminary findings from the new survey. - Marla C. Dubinsky, MD, Professor, Pediatrics, Gastroenterology, Icahn School of Medicine at Mount Sinai, Chief, Pediatric Gastroenterology and Hepatology, Kravis Children’s Hospital at Mount Sinai Learn more: https://michiganmomliving.com/2018/02/05/new-survey-focused-on-how-people-living- with-ulcerative-colitis-may-be-impacted-in-their-daily-life-interview/

Refinery 29 – February 5 How To Get Rid Of Cystic Acne, According To Top Derms — Erika Stalder A 2011 study showed that nearly half of women aged 20-29 has clinical acne. One of the most notorious types is the cystic variety, which can be brought on by monthly hormonal cycles – and can be way more intense to deal with than your average pimple. “Cysts are like balloons under the skin that are filled with oil, but have no place to go. As your oil glands make more oil, cysts become enlarged, the wall cracks, and inflammation develops,” explained Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at the Mount Sinai Hospital. Though Accutane has proven controversial for some, Marina Peredo, MD, assistant clinical professor of dermatology at the Icahn School of Medicine at Mount Sinai, also likes the medication to treat cystic acne. “For most patients, it’s a cure and will prevent deep scar formation if started early in a course of a disease,” she said, noting that a proactive approach is key. “It is very important to start Accutane as soon as possible with severe cystic acne because prolonging the start of treatment can cause deep scars, which are very heard to treat even with the most aggressive laser treatments later.” - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital - Marina Peredo, MD, Assistant Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: http://www.refinery29.com/cystic-acne-treatments?utm_source=feed&utm_medium=rss

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - February 7, 2018 Date: Wednesday, February 07, 2018 12:28:17 PM Attachments: ATT00001.txt

In the News February 7, 2018

Norwalk Patch – February 7 Stamford Company Launches Disease-Screening Product For Newborns — Alfred Branch A Mount Sinai Health System venture, Sema4, a health information company providing advanced genomic testing, announced the launch of Sema4 Natalis, a supplemental newborn screening test designed to detect 193 childhood-onset diseases or disorders so parents can gain insight into their baby’s health. This simple genetic test can be performed at home with a gentle cheek swab. "Until now, families have been likely to be caught off-guard by these early-onset diseases, and prognosis is often poor by the time symptoms have manifested. Thanks to breakthroughs in science and medicine, we can now identify babies at risk for these broader set of diseases and deliver interventions – sometimes as simple as vitamin supplements – in time to make a real difference," said Eric Schadt, PhD, dean of precision medicine, professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai, and founder and CEO of Sema4. “We believe Sema4 Natalis will give parents the advantage of early insight in support of the care of their children.” - Eric Schadt, PhD, Dean, Precision Medicine, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Founder and CEO, Sema4 Learn more: https://patch.com/connecticut/norwalk/s/gcnsl/stamford-company-launches-disease-screening-product- newborns?utm_source=article- mostrecent&utm_medium=rss&utm_term=health%20%26%20fitness&utm_campaign=recirc&utm_content=normal Additional coverage: Stamford Patch https://patch.com/connecticut/stamford/stamford-company-launches-disease-screening-product- newborns?utm_source=article- mostrecent&utm_medium=rss&utm_term=health%20%26%20fitness&utm_campaign=recirc&utm_content=normal New Canaan Patch https://patch.com/connecticut/newcanaan/s/gcnsl/stamford-company-launches-disease-screening- product-newborns?utm_source=article- mostrecent&utm_medium=rss&utm_term=health%20%26%20fitness&utm_campaign=recirc&utm_content=normal Erie News http://www.erienewsnow.com/story/37446661/sema4-launches-supplemental-newborn-screening-test-for- 190-childhood-onset-diseases Xconomy https://www.xconomy.com/new-york/2018/02/07/with-new-test-schadts-sema4-aims-to-broaden-scope-of- newborn-screening/ TMC News http://www.tmcnet.com/usubmit/2018/02/07/8695927.htm

What Is Epigentics – February 6 Natural Compounds In Grapes Could Lead Us To An Epigenetic Treatment For Depression — Bailey Kirkpatrick In a new epigenetic study published in Nature Communications, researchers from the Icahn School of Medicine at Mount Sinai have identified two compounds or found in grapes that are effective in promoting resilience against stress and reducing depression in a mouse model. A team of investigators led by Giulio Maria Pasinetti, PhD, Saunders professor of neurology and program director for the center for molecular integrative neuroresilience at the Icahn School of Medicine at Mount Sinai combined three grape-derived polyphenol products – Concord grape juice, trans-resveratrol, and a select grape seed extract – to form a bioactive dietary polyphenol preparation. This mixture has shown to help reduce stress-induced depression and boost resilience in mice. “Our research shows that combination treatment with the two compounds can promote resilience against stress-mediated depression-like phenotypes by modulating systemic inflammatory responses and brain synaptic plasticity in a mouse model of depression,” said first author Jun Wang, PhD, associate professor of neurology at the Icahn School of Medicine at Mount Sinai. - Giulio Maria Pasinetti, PhD, MD, Saunders Professor, Neurology, Program Director, Center for Molecular Integrative Neuroresilience, Icahn School of Medicine at Mount Sinai - Jun Wang, PhD, Associate Professor, Neurology, Icahn School of Medicine at Mount Sinai Learn more: https://www.whatisepigenetics.com/natural-compounds-grapes-lead-us-epigenetic-treatment-depression/ Additional coverage: WJXT News4Jax https://www.news4jax.com/news/wine-could-treat-depression-study-finds Medical Daily Times http://medicaldailytimes.com/medical-research/can-grape-extracts-treat-depression/3314/ Psych Congress Network https://www.psychcongress.com/article/grape-derived-compounds-show-promise-future- depression-treatment

Physician’s Briefing – February 6 Possible Link Found Between Poor Diet And Back Injuries A high advanced glycation end product (H-AGE) diet is associated with decreased vertebral microstructure, mechanical behaviors, and fracture resistance in young female mice, according to a study published recently in the Journal of Bone and Mineral Research. Svenja Illien-Junger, PhD, assistant professor of orthopaedics at the Icahn School of Medicine at Mount Sinai, and colleagues examined whether high dietary AGE ingestion would diminish vertebral structure and function in a sex- and age-dependent manner. "We conclude that an H-AGE diet, without diabetic or overweight conditions, diminished vertebral microstructure, mechanical behaviors, and fracture resistance in young female mice in a manner suggesting accelerated bone aging," the authors write. - Svenja Illien-Junger, PhD, Assistant Professor, Orthopaedics, Icahn School of Medicine at Mount Sinai Learn more: http://www.physiciansbriefing.com/Article.asp?AID=730817 Additional coverage: Medical Xpress https://medicalxpress.com/news/2018-02-link-poor-diet-injuries.html Doctors Lounge https://www.doctorslounge.com/index.php/news/pb/78276

Connecticut Post – February 6 Trumbull Girl Works On Language With New Implant — Sophia Kunthara Tessa Arden, a seven year old girl from India adopted from an orphanage, recently received a Cochlear Implant enabling her to hear sounds for the first time. She has been working with a speech pathologist to learn how to communicate. It’s a far cry from where Teesa was a year ago, where her only way to communicate was with hand motions or gibberish. Teesa is the first person in the Northeast to receive the new “SlimJ” cochlear implant, a two-piece hearing device with an advanced electrode that was approved by the FDA in November. She became one of the first people in the country to receive the device at all when it was implanted during a December surgery at the New York Eye and Ear Infirmary of Mount Sinai. “When I first met her she had zero words, like not even a single word,” said Maura Cosetti, MD, director of the cochlear implant center at the ear institute at the New York Eye and Ear Infirmary of Mount Sinai. “But she's so interactive and so bubbly and clearly so attentive to the world that, by the time that she got this implant, she had like three words that she could say perfectly. That rate of speech development is remarkable.” Cochlear implants are like phones, Dr. Cosetti said, where new technology is introduced regularly. The “SlimJ” implant Teesa received is a very soft and thin wire that was “snaked” into her cochlea to provide sound stimulation to her inner ear. - Maura K. Cosetti, MD, Assistant Professor, Otolaryngology, Neurosurgery, Icahn School of Medicine at Mount Sinai, Director, The Cochlear Implant Center, Ear Institute, New York Eye and Ear Infirmary of Mount Sinai Learn more: http://www.ctpost.com/local/article/Trumbull-girl-hears-for-first-time-with-new-12555902.php Additional coverage: Fairfield Citizen http://www.fairfieldcitizenonline.com/local/article/Trumbull-girl-hears-for-first-time-with-new- 12555902.php Stamford Advocate http://www.stamfordadvocate.com/local/article/Trumbull-girl-hears-for-first-time-with-new- 12555902.php New Canaan News http://www.newcanaannewsonline.com/local/article/Trumbull-girl-hears-for-first-time-with-new- 12555902.php Greenwich Time http://www.greenwichtime.com/local/article/Trumbull-girl-hears-for-first-time-with-new- 12555902.php

HealthDay – February 7 It’s A Century Since The 1918 Flu Pandemic, Could It Happen Again? — Dennis Thompson One hundred years ago, the deadliest influenza pandemic of all time made a ravaging march across the globe. That raises the inevitable question as the United States battles its way through another severe flu season – could a pandemic as devastating in scope occur in the future? Many medical advances since 1918 have improved people's ability to survive a flu infection, including antivirals and antibiotics, ventilators and vaccinations to protect against both the flu and pneumonia, said Nicole Bouvier, MD, associate professor of medicine, infectious disease and microbiology at the Icahn School of Medicine at Mount Sinai. "We have good supportive care to nurse people through an acute and horrible case of flu," Dr. Bouvier said. "We're better able to get people through a critical illness than we were in 1918." Additionally, the 1918 influenza virus – an H1N1 strain – seems to have been more virulent than any flu that’s since gone on to cause a pandemic, she added. "It certainly is possible that a flu virus could again arise in the animal reservoir that is more pathogenic than the typical flu," Dr. Bouvier said. - Nicole M. Bouvier, MD, Associate Professor, Medicine, Infectious Diseases, Microbiology, Icahn School of Medicine at Mount Sinai Learn more: https://consumer.healthday.com/infectious-disease-information-21/flu-news-314/it-s-a-century-since-the- 1918-flu-pandemic-could-it-happen-again-730888.html Additional coverage: Medical Xpress https://medicalxpress.com/news/2018-02-century-flu-pandemic-.html Drugs.com https://www.drugs.com/news/s-century-since-1918-flu-pandemic-could-happen-again-68616.html? utm_source=ddc&utm_medium=rss&utm_campaign=It%27s+a+Century+Since+the+1918+Flu+Pandemic+- +Could+It+Happen+Again%3F UPI https://www.upi.com/Health_News/2018/02/07/A-century-after-1918-flu-pandemic-experts-say-it-could-happen- again/6511518018027/ The Philadelphia Inquirer http://www.philly.com/philly/health/topics/HealthDay730888_20180207_It_s_a_Century_Since_the_1918_Flu_Pandemic_- _Could_It_Happen_Again_.html U.S. News & World Report https://health.usnews.com/health-care/articles/2018-02-07/its-a-century-since-the-1918-flu- pandemic-could-it-happen-again

KPCW Radio – February 6 This Green Earth— Nell Larson and Chris Cherniak Nell and Chris speak with Philip Landrigan, MD, MSc, professor of environmental medicine and public health and the dean for global health at the Icahn School of Medicine at Mount Sinai, about the links between toxic chemicals in the environment and disease in children. “The incidence of childhood cancer has been rising steadily. We have seen approximately a 40 percent increase in the incidence of childhood cancer. We have connected certain cancers to chemicals in our environment,” Dr. Landrigan said. - Philip Landrigan, MD, MSc, Professor, Environmental Medicine and Public Health, Pediatrics, Dean for Global Health, Icahn School of Medicine at Mount Sinai Learn more: http://kpcw.org/post/green-earth-february-6-2018#stream/0

New York Daily News – February 6 How Winter Warriors Can Stay Fit, Healthy And Injury-Free — Alexis Colvin, MD “For orthopedic surgeons like me, winter is the season for sports injuries, especially to the crucial ligaments that support the knee,” said Alexis Colvin, MD, associate professor of sports medicine and orthopaedics at the Icahn School of Medicine at Mount Sinai. So now is the time to think about how to stay fit and healthy, whether on the ski slopes or just when shoveling your stoop or driveway. “The most common ski injury I see is a torn anterior cruciate ligament, an injury that also bedevils athletes requiring a pivoting motion. A fall, a collision, or even losing your balance can cause a tear.” The most important step to prepare you for winter sports is preconditioning – in particular working on flexibility, core strengthening, and cardio, Dr. Colvin said. The core muscles are key players in skiing, and they are often overlooking in the off-season. To prevent that, “I recommend doing lunges and planks, both to the front and side.” - Alexis Colvin, MD, Associate Professor, Sports Medicine, Orthopaedics, Icahn School of Medicine at Mount Sinai, Chief Medical Officer, United States Tennis Association Learn more: http://www.nydailynews.com/life-style/winter-warriors-stay-fit-healthy-injury-free-article-1.3803081

Health Exec – February 7 What Drove Hospitals’ Rapid Expansion Of — John Gregory In 2000, less than 25 percent of U.S. hospitals with more than 50 beds had palliative care teams. By 2015, that number had jumped to 75 percent, which, according to a study published in Health Affairs, can be largely attributed to training and leadership initiatives. The Center to Advance Palliative Care was founded at the Icahn School of Medicine at Mount Sinai in 1999, aimed at expanding access to palliative care by promoting specialty, motivating hospitals and physicians which may be interested and offering a variety of tools to help facilitate plan, implement and maintain palliative care programs. - Icahn School of Medicine at Mount Sinai Learn more: http://www.healthexec.com/topics/leadership/what-drove-hospitals%E2%80%99-rapid-expansion- palliative-care

Reuters – February 6 Kids With Food Allergies Often Put At Risk By Their Parents — Shereen Lehman Parents of kids with food allergies often engage in behaviors that could trigger an allergic reaction in their child, a survey found. Almost half of parents of kids with food allergies reported at least one risky behavior, such as not carrying epinephrine autoinjectors or not reading food labels. These behaviors are likely due to knowledge gaps and misconceptions, as well as possible financial barriers, according to Julie Wang, MD, associate professor of pediatrics, allergy and immunology at the Icahn School of Medicine at Mount Sinai. Dr. Wang’s team conducted the survey to better understand food allergy management behaviors and attitudes in their patients’ households. “During our patient visits, we routinely counsel families about food allergy management to reduce the risk of allergic reactions. However, we noted that in some cases, our patients experienced allergic reactions that were associated with risk-taking behavior, Dr. Wang said. “It is important to understand the barriers patients and their families face in managing their food allergies,” she added. Nearly one in four parents said they intentionally exposed their kids to the food allergens to see if they were still allergic or to “treat” the underlying allergy. - Julie Wang, MD, Associate Professor, Pediatrics, Allergy and Immunology, Icahn School of Medicine at Mount Sinai Learn more: https://www.reuters.com/article/us-health-kids-food-allergies/kids-with-food-allergies-often-put-at-risk-by- their-parents-idUSKBN1FQ2JF Additional coverage: WHTC http://whtc.com/news/articles/2018/feb/06/kids-with-food-allergies-often-put-at-risk-by-their-parents/ SRN News https://www.srnnews.com/kids-with-food-allergies-often-put-at-risk-by-their-parents/

Reader’s Digest – February 6 Nine Diabetes Myths That Could Be Sabotaging Your Health — Alyssa Jung Initial signs of elevated blood sugar are often so mild that they’re easily overlooked. This is why it’s important to regularly test and track blood sugar levels. Not only can this alert you to dip or spike even before your body sends you signals, it also helps you learn how diet, exercise, stress, and illness affects your levels. When you’re hypoglycemic, you may experience sweating or shakiness. But long-term diabetics often develop something called “hypoglycemia unawareness,” which means they lose the ability to feel these symptoms as time goes on, said Deena Adimoolam, MD, assistant professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai. Closely follow your doctor’s recommendation for how often to check blood sugar levels. - Deena Adimoolam, MD, Assistant Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai Learn more: https://www.rd.com/health/conditions/diabetes-myths/

Allure Magazine – February 6 Short-Term Radiation Is Safe For Treating Basal And Squamous Cell Skin Cancers, Study Says — Macaela Mackenzie For shady moles, short-term high-powered doses of radiation might be a more effective form of skin cancer treatment than scientists previously thought, according to a new study published in the journal Radiotherapy & Oncology. Basal and squamous cell carcinomas aren’t uncommon, as 5.4 million cases are diagnosed each year, according to the American Cancer Society. While radiation zaps the cancerous cells, it also affects the healthy skin cells, said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at The Mount Sinai Hospital. “After treatment, many people sustain some degree of skin damage, known as radiation dermatitis,” he said. “It has traditionally been thought that the higher the amount of energy per treatment, the fewer the number of treatments you need, but the higher the risk of developing general risk skin damage to that area.” - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.allure.com/story/short-term-radiation-safe-for-skin-cancer-treatment

Self Magazine – February 6 Stacy London Developed Depression After Spinal Surgery Last Year — Korin Miller Former What Not to Wear star Stacy London just revealed in an honest essay that she suffered from chronic back pain – and she experienced clinical depression after undergoing surgery to correct her pain. London said she was “foggy” post- op thanks to the pain meds she was on, but even after she went off the medication she was in severe pain. Just over eight weeks after surgery, she started to experience anxiety and depression. Unfortunately, it’s not unheard of for someone to become depressed after having surgery – especially spinal surgery. You’re putting your body – and your emotions – through a lot all at once. “Anything that is a physical or a psychological stressor can increase your risk of depression – and major surgery can be both,” said James Murrough, MD, assistant professor of psychiatry, neuroscience, and director of the mood and anxiety disorders program at the Icahn School of Medicine at Mount Sinai. If someone was previously active before their surgery and then are limited in what they can do post-op, it could trigger depression. Post-op pain can also be a factor, as well as physical and emotional stress from undergoing surgery, Dr. Murrough added. - James Murrough, MD, Assistant Professor, Psychiatry, Neuroscience, Director, Mood and Anxiety Disorders Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.self.com/story/stacy-london-depression-after-spinal-surgery

Self Magazine – February 6 Chrissy Teigen Says Her Baby Is ‘Sucking The Life’ From Her — Korin Miller Chrissy Teigen recently revealed that headaches aren’t the only thing that’s been rough about her second pregnancy. “This baby is sucking the life from me. Drinking my water, making me dry. Eating my food, making me hungry. Taking my health, making me sick,” she wrote on Twitter. Teigen was probably exaggerating a bit, but she’s obviously not the only one who has felt this way. “Every pregnant woman has a bad day where she thinks she can’t be pregnant for another second, and typically it gets better,” said Fahimeh Sasan, DO, assistant professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai. “Unless you have a serious chronic medical issue to begin with, being pregnant is not going to impact your overall health or bring you bodily harm.” If you do have a chronic health issue, such as diabetes, your doctor can help you manage the effects of pregnancy before, during, and after you become pregnant. - Fahimeh Sasan, DO, Assistant Professor, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.self.com/story/chrissy-teigen-says-her-baby-is-sucking-the-life-from-her Additional coverage: Yahoo News https://www.yahoo.com/lifestyle/chrissy-teigen-says-her-baby-183834285.html

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - February 8, 2018 Date: Thursday, February 08, 2018 1:45:07 PM Attachments: ATT00001.txt

In the News February 8, 2018

WABC-7 News – February 7 Children Reunite With Doctors Who Saved Their Lives— A.J. Ross With Valentine’s Day next week, a very special group of children gathered to celebrate early. Their common bond – they were all saved by heart surgery at The Kravis Children’s Hospital at Mount Sinai. Sabrina Ho had her first heart transplant at five months old, her second one at 13 years old, and now she is a 21-year-old college student with a heart pumping strong. Ho met dozens of others at Mount Sinai Hospital who were saved by heart surgery when they were kids. Some still are kids. “It’s painful obviously. I know what they’re going through but at the same time if I can be a role model and influence, it’s lovely,” said Ho. “I think it’s a privilege for physicians who have patients chronically, to have these relationships, they’re so special. It’s an extended family really,” said Ira Parness, MD, professor of pediatrics and cardiology and chief in the division of pediatric cardiology at the Icahn School of Medicine at Mount Sinai. Performing nearly 200 pediatric heart operations a year, physicians utilize state-of-the-art procedures ranging from valve repairs to heart transplants. - Ira Parness, MD, Professor, Pediatrics, Cardiology, Chief, Division of Pediatric Cardiology, Icahn School of Medicine at Mount Sinai Learn more: http://abc7ny.com/health/children-reunite-with-doctors-who-saved-their-lives/3049434/ Additional coverage: Fox Newshttp://www.fox5ny.com/news/heart-surgery-patients-celebration WCBS New York Radio http://newyork.cbslocal.com/2018/02/07/mt-sinai-hospital-heart-patients/

Queens Gazette – February 7 Mount Sinai Queens Celebrates ‘Go Red For Women’ Mount Sinai Queens kicked off National Heart Month with a health and wellness event to promote heart health in the Queens community. The event featured free blood pressure screenings and a presentation by George D. Dangas, MD, PhD, professor of medicine, cardiology and surgery at the Icahn School of Medicine at Mount Sinai and director of cardiovascular innovation at the Zena and Michael A. Weiner Cardiovascular Institute at the Mount Sini Health System. The nationwide Go Red for Women campaign is promoted by the American Heart Association to raise awareness and advance the prevention and treatment of heart disease, the number-one killer of women. Physicians and staff at Mount Sinai Queens wore red on Friday to show their support of this important program. “We encourage women to take action to reduce their personal risk of heart disease and to understand how diet, exercise, and monitoring their risk factors, including blood pressure and cholesterol, can lead to good heart health and a longer and more active life,” said Caryn A. Schwab, executive director of Mount Sinai Queens. “Since 80 percent of cardiac events can be prevented with education and lifestyle changes, we hope women will visit their primary care doctors or cardiologists to get ahead of the curve.” - George D. Dangas, MD, PhD, Professor, Medicine, Cardiology, Surgery, Icahn School of Medicine at Mount Sinai, Director, Cardiovascular Innovation, The Zena and Michael A. Weiner Cardiovascular Institute, Mount Sinai Health System - Caryn A. Schwab, Executive Director, Mount Sinai Queens Learn more: http://www.qgazette.com/news/2018-02- 07/Features/Mount_Sinai_Queens_Celebrates_Go_Red_for_Women.html

Digital Journal – February 7 Sema4 Launches Supplemental Newborn Screening Test For 190+ Childhood Onset Diseases A Mount Sinai Health System venture, Sema4, a health information company providing advanced genomic testing, announced the launch of Sema4 Natalis, a supplemental newborn screening test designed to detect 193 childhood-onset diseases or disorders so parents can gain insight into their baby’s health. This simple genetic test can be performed at home with a gentle cheek swab. "Until now, families have been likely to be caught off-guard by these early-onset diseases, and prognosis is often poor by the time symptoms have manifested. Thanks to breakthroughs in science and medicine, we can now identify babies at risk for these broader set of diseases and deliver interventions – sometimes as simple as vitamin supplements – in time to make a real difference," said Eric Schadt, PhD, dean of precision medicine, professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai, and founder and CEO of Sema4. “We believe Sema4 Natalis will give parents the advantage of early insight in support of the care of their children.” - Eric Schadt, PhD, Dean, Precision Medicine, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Founder and CEO, Sema4 Learn more: http://www.digitaljournal.com/pr/3648996 Additional coverage: MIT Technology Review https://www.technologyreview.com/s/610197/a-new-dna-test-will-look-for-190- diseases-in-your-newborns-genetic-code/ Hartford Business http://www.hartfordbusiness.com/article/20180207/NEWS/180209925 The Week Magazine http://theweek.com/speedreads/753773/theres-new-dna-test-babies-that-check-193- genetic-diseases Financial Buzz http://www.financialbuzz.com/sema4-launches-supplemental-newborn-screening-test-for- 190-childhood-onset-diseases-998529 Stamford Advocate https://www.stamfordadvocate.com/business/article/Sema4-launches-newborn- screening-test-12559674.php

Health Affairs – February 7 Health Philanthropy Staff And Board Changes; Awards— Lee-Lee Prina Diane Meier, MD, professor of geriatrics and palliative medicine, vice chair of public policy at the Icahn School of Medicine at Mount Sinai and director for the Center to Advance Palliative Care, was awarded the National Academy of Medicine’s Gustav O. Lienhard Award for Advancement of Health Care. This award is funded by an endowment from the Robert Wood Johnson Foundation. Dr. Meier received the award because of her leading role in driving awareness and adoption of palliative care services in the United States. - Diane E. Meier, MD, FACP, Professor, Geriatrics and Palliative Medicine, Medicine, Vice Chair, Public Policy, Icahn School of Medicine at Mount Sinai, Director, Center to Advance Palliative Care Learn more: https://www.healthaffairs.org/do/10.1377/hblog20180207.185048/full/

Chelsea News – February 7 The Singsong Of The Siren — Douglas Feiden The jarring wail of the Mount Sinai Health System ambulance fleet has been unplugged as hospital execs introduce the “Hi-Low,” with kinder, gentler, European-style rhythms. For years, Mount Sinai field complaints about the unpleasant blaring of its ambulances and their unfortunate role in abetting urban noise pollution. “Our neighbors and pedestrians hated the jarring sounds and the shrieking of the sirens,” said Joseph J. Davis, director of emergency medical services at the Mount Sinai Health System. He said we took those complaints to heart. Last September, it devised a far more melodious offering with a lower pitch that has been playing to most favorable reviews since it was introduced in October. “It still makes the same amount of noise, but it’s no longer an offensive noise. It cascades up, and then it comes down. It’s more rhythmic, a lot more pleasant, and much less offensive. The complaints have basically stopped,” said Davis. - Joseph J. Davis, Director, Emergency Medical Services, Mount Sinai Health System Learn more: http://www.chelseanewsny.com/local-news/20180207/the-singsong-of-the-siren/2

CNBC News – February 7 Weight Watchers Shares Plan To Rebrand — Angelica LaVito Weight Watchers will offer teens aged 13 to 17 free memberships this summer as part of its plan to help ten million people adopt healthy habits and grow its revenue to more than two billion by 2020. The company said it is rebranding to focus itself on the purpose of inspiring healthy habits for life. Encouraging teens to count calories and diet is dangerous, said Tomi Akanbi, MS, RD, clinical nutrition coordinator at the Mount Sinai Adolescent Health Center. She sees patients who adopt their parents’ weight-loss plans, not realizing that teens need to eat certain foods to help them grow. When teens focus on calories, she said, they tend to skip meals and eat too little or replace them with empty calories from sugary sources like soda. Instead, she encourages teens to create a diet that's heavy in fruits, vegetables, protein and grains and void of refined starches and sugars, mixed with at least an hour of daily exercise. "Weight Watchers really is dieting and focusing on just weight, and research has shown when the focus is on weight and dieting in teens, that is not an effective way to promote and sustain weight loss," Dr. Akanbi added. "It's not even helpful to promote overall wellness because we're also talking about body image and how these kids are experiencing themselves and food and their bodies, and dieting does not help with that." - Tomi Akanbi, MS, RD, Clinical Nutrition Coordinator, Mount Sinai Adolescent Health Center Learn more: https://www.cnbc.com/2018/02/07/weight-watchers-will-offer-teens-as-young-as-13-free- memberships.html

Managed Care Magazine – February 7 It’s A Century Since The 1918 Flu Pandemic, Could It Happen Again? One hundred years ago, the deadliest influenza pandemic of all time made a ravaging march across the globe. That raises the inevitable question as the United States battles its way through another severe flu season – could a pandemic as devastating in scope occur in the future? Many medical advances since 1918 have improved people's ability to survive a flu infection, including antivirals and antibiotics, ventilators and vaccinations to protect against both the flu and pneumonia, said Nicole Bouvier, MD, associate professor of medicine, infectious disease and microbiology at the Icahn School of Medicine at Mount Sinai. "We have good supportive care to nurse people through an acute and horrible case of flu," Dr. Bouvier said. "We're better able to get people through a critical illness than we were in 1918." Additionally, the 1918 influenza virus – an H1N1 strain – seems to have been more virulent than any flu that’s since gone on to cause a pandemic, she added. "It certainly is possible that a flu virus could again arise in the animal reservoir that is more pathogenic than the typical flu," Dr. Bouvier said. - Nicole M. Bouvier, MD, Associate Professor, Medicine, Infectious Diseases, Microbiology, Icahn School of Medicine at Mount Sinai Learn more: http://www.managedcaremag.com/news/20180207/its-century-1918-flu-pandemic-could-it- happen-again Additional coverage: WebMD https://www.webmd.com/cold-and-flu/news/20180207/could-the-deadly-1918-flu-pandemic- happen-again?src=RSS_PUBLIC#1 P&T Community https://www.ptcommunity.com/news/20180207/its-century-1918-flu-pandemic-could-it- happen-again Doctors Lounge https://www.doctorslounge.com/index.php/news/hd/78288

Consumer Reports – February 7 How To Handle A Persistent Cough — Tula Karras Respiratory tract infections such as colds and flu are the leading reason for short-term coughs. Older adults are slightly more likely to develop acute-bronchitis – an inflammation of the bronchial tubes that’s marked by coughing – as a result. There are several possible reasons for a persistent cough. Mucus production may continue after infection, only gradually fading away. In some people, a respiratory infection can cause prolonged airway irritation – which can be accompanied by a persistent cough. Or airways may become so sensitized by coughing during infection that simple breathing or talking can set off coughing episodes. “This sensitization can trigger coughing, and – in a vicious cycle – coughing can further sensitize the nerves,” said Neil Schachter, MD, professor of medicine, pulmonary, critical care and sleep medicine at the Icahn School of Medicine at Mount Sinai. When a cough lasts for eight weeks or longer, it’s considered chronic. See your doctor if you have a cough that persists for this long and are unsure why. - Neil E. Schachter, MD, Professor, Medicine, Pulmonary, Critical Care and Sleep Medicine, Pediatrics, Preventive Medicine, Environmental Medicine and Public Heath, Icahn School of Medicine at Mount Sinai Learn more: https://www.consumerreports.org/cough/how-to-handle-a-persistent-cough/

Everyday Health – February 1 Crohn’s And Iron Deficiency Anemia: What’s The Link? — Quinn Phillips If you have Crohn’s disease, you’re probably familiar with the fatigue that often accompanies it. Fatigue can result directly from Crohn’s, it’s corresponding gastrointestinal (GI) symptoms, or the psychological toll of managing a chronic condition like Crohn’s, and it may negatively affect both your work and personal life. Iron deficiency anemia can have a detrimental effect on the quality of life of people with Crohn’s or other forms of inflammatory bowel disease (IBD). While iron deficiency can have a number of potential causes, in people with Crohn’s disease, it most commonly occurs as a result of bleeding in the digestive tract. When this happens, people “are usually unaware that they are losing blood,” said James Marion, MD, professor of medicine and gastroenterology at the Icahn School of Medicine at Mount Sinai and director of education and outreach at the Susan and Leonard Feinstein Inflammatory Bowel Disease Clinical Center at The Mount Sinai Hospital. That’s because the blood loss can happen gradually over a long period of time, without overt symptoms. In people with Crohn’s disease, Dr. Marion said, this blood loss usually occurs because of disease activity. The digestive tract contains lots of blood vessels, he noted, which can rupture when Crohn’s-related ulcers and fissures penetrate beneath the inner mucosal layer of the intestines. - James F. Marion, MD, Professor, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai, Director, Education and Outreach, Susan and Leonard Feinstein Inflammatory Bowel Disease Clinical Center at The Mount Sinai Hospital Learn more: https://www.everydayhealth.com/hs/iron-deficiency-anemia/crohns/

Diabetes In Control – January 27 AACE 2017- The Transition Process: A Key To Best Adjuvant Care— Steve Freed There are multiple areas of transition. “When children age out of our age group of comfort, we do want to have a place for these individuals to continue their care. That is what the transition program is all about. When they become adults, the idea would be to have them go from a pediatrics practice to the adult practice. The ways of doing that are the core to having continuity of care and assuring excellence in care,” said Robert Rapaport, MD, professor of pediatrics and chief of the division of pediatric endocrinology and diabetes at the Icahn School of Medicine at Mount Sinai. “Transitioning them over to an adult specialist varies tremendously, somewhere between 18 and 21, but most of our patients with diabetes we do take them through college and arrange for transition after that.” He added that certainly by the time of their mid-twenties it would be reasonable to transition them to an adult care practice. - Robert Rapaport, MD, Professor, Pediatrics, Chief, Division of Pediatric Endocrinology and Diabetes, Icahn School of Medicine at Mount Sinai Learn more: http://www.diabetesincontrol.com/robert-rapaport-full-interview/

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - February 9, 2018 Date: Friday, February 09, 2018 1:11:46 PM Attachments: ATT00001.txt

In the News February 9, 2018

Hartford Courant – February 9 Stamford Health Company Can Screen Newborns For 193 Conditions — Rebecca Lurye A Stamford-based health information company wants to use DNA sequencing to give parents more information from the start of their children’s health. Sema4, which spun out of the Mount Sinai Health System, has developed a supplemental newborn screening test called Natalis that covers 193 childhood- onset disease and disorders – all treatable with medication, dietary changes or other therapies, if caught early. “Until now, families have been likely to be caught off-guard by these early-onset diseases, and prognosis is often poor by the time symptoms have manifested,” said Eric Schadt, PhD, dean of precision medicine, professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai, and founder and CEO of Sema4. “Thanks to breakthroughs in science and medicine, we can now identify babies at risk for these broader set of diseases and deliver interventions — sometimes as simple as vitamin supplements — in time to make a real difference.” Its new screening also offers parents an opportunity to analyze their child’s response to more than 30 medications commonly prescribed during childhood, such as antibiotics. - Eric Schadt, PhD, Dean, Precision Medicine, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Founder and CEO, Sema4 Learn more: http://www.courant.com/business/hc-biz-stamford-newborn-screening-20180208-story.html Additional coverage: Xconomy Bio Roundup https://www.xconomy.com/national/2018/02/09/bio-roundup-lung-cancer- questions-migraine-races-hiv-battle-more/ Fox TV affiliates – No links available GenomeWeb https://www.genomeweb.com/scan/wider-screen

Medical News Today – February 9 Psychotic Disorders: Childhood IQ May Predict Onset — Tim Newman Cognitive impairments are a key feature of psychotic disorders. The latest research shows that these deficits can be spotted when a person is as young as 4 years old. The researchers behind a new study — who are all interested in the cognitive aspects of psychiatric disease — hail from King's College London's Institute of Psychiatry, Psychology, and Neuroscience and the Icahn School of Medicine at Mount Sinai. They recently published the details of their latest study in the journal JAMA Psychiatry. "It is important to bear in mind that many children will experience some difficulties with school work or other intellectual tasks at some point in their lives, and only a small minority will go on to develop a psychotic disorder,” said senior study author, Abraham Reichenberg, PhD, professor of psychiatry at the Icahn School of Medicine at Mount Sinai. Following on from this, Dr. Reichenberg plans to study brain changes in individuals who eventually develop psychosis. He also wants to take a closer look at potential environmental and genetic risk factors that could predispose someone to poorer cognitive abilities. - Abraham Reichenberg, PhD, Professor, Psychiatry, Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai Learn more: https://www.medicalnewstoday.com/articles/320847.php

CUNY TV: Science & U! – February 8 Cryoablation: Less Invasive Treatment Finding Some Success — Dr. Max Gomez Everyone is impacted by cancer in some way or another and we all wish the treatments weren’t so demanding on the body. Dr. Max Gomez visits Mount Sinai Union Square to learn about a lesser-known and less invasive treatments that’s finding some success, it’s called cryoablation. “You are freezing the tissue, creating icicles and ice inside the tissue and the cells. But that’s not what kills the tissue. What it does is actually the thawing phase, which bursts those cells,” said Michael A. Palese, MD, site chair for the department of urology at Mount Sinai Downtown and professor of urology at the Icahn School of Medicine at Mount Sinai. Cryoablation involves inserting a probe into cancerous tumors inside the body, and then freezing them with liquid nitrogen, or very cold argon gas. Precise placement is key, aided by imaging, like ultrasounds or CAT scans. “We have been using it particularly for prostate cancer for a number of years. It has also been used successfully for kidney cancer,” Dr. Palese added. - Michael A. Palese, MD, Site Chair, Department of Urology, Mount Sinai Downtown, Professor, Urology, Icahn School of Medicine at Mount Sinai Learn more: http://www.cuny.tv/show/scienceandu/PR2006894

Chicago Tribune – February 9 Could The Deadly 1918 Flu Pandemic Happen Again? — Dennis Thompson One hundred years ago, the deadliest influenza pandemic of all time made a ravaging march across the globe. That raises the inevitable question as the United States battles its way through another severe flu season – could a pandemic as devastating in scope occur in the future? Many medical advances since 1918 have improved people's ability to survive a flu infection, including antivirals and antibiotics, ventilators and vaccinations to protect against both the flu and pneumonia, said Nicole Bouvier, MD, associate professor of medicine, infectious disease and microbiology at the Icahn School of Medicine at Mount Sinai. "We have good supportive care to nurse people through an acute and horrible case of flu," Dr. Bouvier said. "We're better able to get people through a critical illness than we were in 1918." Additionally, the 1918 influenza virus – an H1N1 strain – seems to have been more virulent than any flu that’s since gone on to cause a pandemic, she added. "It certainly is possible that a flu virus could again arise in the animal reservoir that is more pathogenic than the typical flu," Dr. Bouvier said. - Nicole M. Bouvier, MD, Associate Professor, Medicine, Infectious Diseases, Microbiology, Icahn School of Medicine at Mount Sinai Learn more: http://www.chicagotribune.com/lifestyles/health/sc-hlth-could-1918-flu-pandemic-happen- again-0221-story.html

The Scientist – February 8 Gene Expression Overlaps Among Psychiatric Disorders — Ashley P. Taylor Psychiatric disorders display common patterns of gene expression, according to a study published in Science. Researchers have analyzed transcripts within the post-mortem brains of hundreds of people with autism, schizophrenia, bipolar disorder, depression, or alcoholism, as well as healthy controls, in order to learn about how gene expression changes within the diseased brain. “I think the study has to be commended in terms of methodological rigor,” said Sophia Frangou, MD, PhD, professor of psychiatry at the Icahn School of Medicine at Mount Sinai, who was not involved in the work. The study’s results are not particularly revelatory, she added, because it’s already known that many genetic variants link different psychiatric disorders. “It’s nice to see this overlap extend into gene expression, but in many ways it’s more confirmatory rather than outright novel.” - Sophia Frangou, MD, PhD, Professor, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.the-scientist.com/?articles.view/articleNo/51636/title/Gene-Expression- Overlaps-Among-Psychiatric-Disorders/

Newsmax – February 8 Weight Watchers For Teens Offered Free For Six Weeks — Zoe Papadakis Weight Watchers for teens across the U.S. will be free this summer as the company embarks upon a rigorous campaign to promote healthy living among the youth while growing its revenue. The six-week promotion kicks off in July and will allow teens between the ages of 13 and 17 free membership in a bid to help those who need healthy habits to develop them at this critical life-stage. "Weight Watchers really is dieting and focusing on just weight, and research has shown when the focus is on weight and dieting in teens, that is not an effective way to promote and sustain weight loss," said Tomi Akanbi, MS, RD, clinical nutrition coordinator for the Mount Sinai Adolescent Health Center. "It's not even helpful to promote overall wellness because we're also talking about body image and how these kids are experiencing themselves and food and their bodies, and dieting does not help with that." - Tomi Akanbi, MS, RD, Clinical Nutrition Coordinator, Mount Sinai Adolescent Health Center Learn more: https://www.newsmax.com/thewire/weight-watchers-teens-free- memberships/2018/02/08/id/842204/

Endocrinology Advisor – February 8 SGLT2 Inhibitors In The Treatment Of Type 2 Diabetes Barrie Weinstein, MD, assistant professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai explains how she approaches risk-benefit discussions regarding sodium-glucose cotransporter2 (SGLT2) inhibitor use in patients who have type 2 diabetes. “Whenever I’m starting a patient on a new medication, I make sure to have an extensive discussion with the patient about the risk and benefits. SGLT2 inhibitors are an attractive option for patients with type 2 diabetes. In addition to lowering hemoglobin A1c and fasting plasma glucose, they have also been associated with weight loss, blood pressure lowering, and reduction in progression of albuminuria,” she said. She added that there has been a lot of positive noteworthy data about SGLT2 inhibitors; however, it is important to discuss the risks. “These medications can be very dehydrating, and is very important to talk to patients about staying hydrated with water throughout the day. If a patient becomes dehydrated while taking these medications, this potentially can lead to deleterious effects on the kidneys, although they can be reversible, or to the development of diabetic ketoacidosis.” - Barrie Weinstein, MD, Assistant Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai Learn more: https://www.endocrinologyadvisor.com/dr-barrie-weinstein/section/8041/? publishDate=False×tamp=636536920047099661

Healthline – February 8 Breast Cancer Treatments Can Increase Risk Of Heart Disease — Ann Pietrangelo Some treatments for breast cancer can harm your heart. And heart disease is the number one cause of death for women in the United States. Some treatments can cause abnormal heart rhythms, weaken the heart muscle, or damage heart cells. One of the treatments is doxorubicin (Adriamycin). Paula Klein, MD, associate professor of medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai said that Adriamycin, also known as the “red devil,” is commonly incorporated into aggressive treatment programs. “It is associated with irreversible toxicity. But the risk is low - less than one percent. It’s higher in older women and those with cardiovascular risk factors,” she explained. Before beginning treatment with Adriamycin and Herceptin, patients get a baseline echocardiogram and MUGA scan, she said. - Paula Klein, MD, Associate Professor, Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://www.healthline.com/health-news/breast-cancer-treatments-can-increase-risk-of- heart-disease

Cosmopolitan – February 8 Nine Flu Myths That Need To Be Shut Down — Elizabeth Narins This year’s flu season has had more hospitalizations than recent years and a record 53 pediatric deaths, according to a recent Centers for Disease Control and Prevention report that suggests the worst may not be over. To protect yourself and others from contracting the flu, don’t just take all the precautions – help stop these common myths about the virus from spreading even further. A popular myth is that the flu shot can give you the flu. “Because it contains an inactive version of the virus, it’s impossible for the shot to infect you,” said Peter Shearer assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and medical director of the emergency department at Mount Sinai Hospital. Coincidence may be responsible for this confusion: vaccine side effects can include flu-like symptoms such as low-grade fever, headache, and muscle aches. People also tend to get vaccinated in the fall and early winter – when other respiratory illnesses, like the common cold, circulate and are often mistaken for the flu, Dr. Shearer said. - Peter Shearer, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Emergency Department, The Mount Sinai Hospital Learn more: http://www.cosmopolitan.com/health-fitness/a16640281/flu-myths/

The New York Times – February 3 Q&A: Possible Mold In The Walls — Ronda Kaysen Mold is serious and need to be taken care of. Although black mold is toxic, common molds can be harmful to your health, too. If you are allergic to mold, it could cause a reaction or exacerbate asthma, and if your immune system is compromised from an illness like HIV or AIDS, such exposure could pose a serious health threat, said Louis DePalo, MD, professor of medicine, pulmonary, critical care and sleep medicine at the Icahn School of Medicine at Mount Sinai. Even if the mold does not bother you now, you should still insist on removing it because “if you continue to live in that space, you might develop an allergy” to mold eventually, Dr. DePalo said. - Louis DePalo, MD, Professor, Medicine, Pulmonary, Critical Care, Sleep Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.nytimes.com/2018/02/03/realestate/possible-mold-in-the-walls-and-an- unresponsive-board.html

Moneyish – February 9 This Is How Nancy Pelosi Gave A Record-Breaking Eight-Hour Speech In Four Inch Heels — Nicole Lyn Pesce As House Minority Leader Nancy Pelosi proved by giving a record-setting eight-hour speech, at age 77, while standing in four-inch heels, women are well-suited to endure discomfort and push through muscle fatigue – sometimes even better than men. David Putrino, PhD, director of rehabilitation innovation at the Mount Sinai Health System and assistant professor of rehabilitation medicine at the Icahn School of Medicine at Mount Sinai, has been studying endurance, pain and fatigue in high performance athletes. “What we know about pain is that pain is relative, so people who have higher pain thresholds have experienced an enormous amount of pain at some point in their lives. So in some cases, women have the higher pain threshold because they have experienced childbirth, and then anything else doesn’t seem so bad, relatively speaking.” But Dr. Putrino has learned that finding fresh vigor in the midst of pain and fatigue is more about mind over matter than it is about being male versus female. “If you are very passionate about something, you can withstand a lot more to make your goal happen,” he said, citing Olympic athletes who perform record-breaking feats through extreme pain. “So at the very least, what we can say for sure, is that Nancy Pelosi was passionate about standing up and talking about what she believed in,” said Dr. Putrino, “and no amount of pain was going to stop her from standing there for eight hours and getting it all out.” - David Putrino, PhD, Assistant Professor, Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, Director, Rehabilitation Innovation, Mount Sinai Health System Learn more: https://moneyish.com/ish/this-is-how-nancy-pelosi-gave-a-record-breaking-eight-hour- speech-in-four-inch-heels/

Huffington Post – February 9 How To Soothe Irritated Skin, According To Dermatologists — Julia Brucculieri Our skin is a fickle organ, especially when it’s on our faces. It can go from clean and clear one moment to red, itchy and irritated another, with no discernible cause. There are a few things you can do to soothe irritated skin. It’s good to consult with a dermatologist if you think the irritation may be due to a more serious issue. Angela Lamb, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of the Westside Mount Sinai Dermatology Faculty Practice, said that irritation is more common in the winter because our skin can be more sensitive during the colder months. “The serums and exfoliating products that you could use in the summer and spring may be too hard for the fall and winter,” Dr. Lamb said. Irritated skin could also be caused by an underlying issue, such as eczema, or an allergy, which Dr. Lamb said can be developed at any age. “I opt for protecting your skin barrier better with a simple moisturizer that will not irritate things even further,” she said. - Angela Lamb, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Westside Mount Sinai Dermatology Faculty Practice Learn more: https://www.huffingtonpost.com/entry/how-to-soothe-irritated- skin_us_5a7b601de4b08dfc92ff75d6

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - February 12, 2018 Date: Monday, February 12, 2018 3:06:49 PM Attachments: ATT00001.txt

In the News February 12, 2018

GenomeWeb – February 12 Sema4 Launches Newborn Screening Targeted Sequencing Test — Monica Heger Sema4, the Mount Sinai Health System spinout that launched last year, has added a sequencing-based newborn screening test that looks for 193 disorders and analyzes pharmacogenomics genes related to 38 common pediatric medications. Eric Schadt, PhD, dean of precision medicine, professor of genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai, and founder and CEO of Sema4, said that the goal was to focus on early-onset, severe, highly penetrant conditions for which early detection is associated with a treatment or intervention to either reduce symptoms or, in some cases, to prevent them altogether. It’s “focused on being medically actionable,” he said, and guidelines exist for how to treat the disorders. The Natalis test is designed for asymptomatic babies whose parents want the extra information, Dr. Schadt said. Order requests for tests will first be reviewed and must be approved by a physician, he said. Sema4 wouldn't perform testing on newborns who were already showing symptoms of a disorder or on children above a certain age, Dr. Schadt added. - Eric Schadt, PhD, Dean, Precision Medicine, Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Founder and CEO, Sema4 Learn more: https://www.genomeweb.com/molecular-diagnostics/sema4-launches-newborn-screening- targeted-sequencing-test

ABC World News Tonight – February 9 Flu Epidemic Spreads — Eva Pilgram The flu season is raging and getting worse. Doctors on the front lines in emergency rooms are noticing the surge. “A few weeks back it was maybe 25 to 30 patients a day, today we are getting up to 40 to 50 patients a day coming in with flu symptoms,” said Peter Shearer, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and medical director in the emergency department at the Mount Sinai Hospital. There have already been more than 17,000 hospitalizations nationwide, on track to break records. The CDC is urging anyone that is recovering from the flu but never got the flu shot to get it as soon as they are better. - Peter Shearer, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Emergency Department, The Mount Sinai Hospital Learn more: http://abc.go.com/shows/world-news-tonight/episode-guide/2018-02/09-020918-kate-upton- accuses-guess-co-founder-sexual-assault

Romper – February 9 A Transgender Woman Has Exclusively Breastfed Her Baby, And It’s A Dream Come True — Christina Ann-Marie DiEdoardo Thanks to work on induced lactation in Transgender women by Tamar Reisman, MD, assistant professor of medicine, endocrinology, diabetes, and bone disease at the Icahn School of Medicine at Mount Sinai and Zil Goldstein, MSN, program director at the center for transgender medicine and surgery at the Mount Sinai Health System, a transgender mother was not only able to breastfeed her child, but to be the baby’s exclusive food source for its first six weeks of life. This is incredible new for families. Creating a standard of care that supports breastfeeding in transgender mothers in key to “building happy, healthy, transgender families,” said Dr. Reisman. While Trans women have experimented for years with methods to induce lactation, usually doing drugs like domperidone on a do it yourself basis, Dr. Reisman and Goldstein’s case report, published in Transgender Health, is the first time medical professionals have worked towards the same goal and published their results in a medical journal. - Tamar Reisman, MD, Assistant Professor, Medicine, Endocrinology, Diabetes, and Bone Disease, Icahn School of Medicine at Mount Sinai - Zil Goldstein, MSN, Assistant Professor, Medical Education, Icahn School of Medicine at Mount Sinai, Program Director, The Center for Transgender Medicine and Surgery, The Mount Sinai Health System Learn more: https://www.romper.com/p/a-transgender-woman-has-exclusively-breastfed-her-baby-its-a- dream-come-true-8146751

CBS New York – February 9 Study Finds Some Healthy Foods Could Help Cancer Spread — Vanessa Murdock Fish, whole grains, asparagus – all are touted as healthy foods. But new research finds a specific amino acid found in each of the nutrient-rich noshes, called asparagine, which could help spread breast cancer. Charles Shapiro, MD, director of cancer survivorship and translational breast cancer research at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, said at this point the research is far removed from practical application. “Don’t stop eating asparagus,” he said. What is proven to improve health is to step up physical activity and eat a well-balanced, sensible diet. “Less red meat, more greens. Cook your food, instead of buying processed food,” Dr. Shapiro added. - Charles Shapiro, MD, Director, Cancer Survivorship, Translational Breast Cancer Research, The Tisch Cancer Institute, Professor, Medicine, Icahn School of Medicine at Mount Sinai Learn more: http://newyork.cbslocal.com/2018/02/09/healthy-foods-cancer-spread/

Newsmax Health – February 11 Secondhand Plastic Toys May Pose Risk Children who play with second-hand plastic toys may be exposed to unsafe levels of chemicals like lead and cadmium that have been linked to developmental problems and organ damage, a UK study suggests. The researchers discovered high concentrations of hazardous elements including antimony, barium, bromine, cadmium, chromium, lead, and selenium in many building blocks, figures and items of jewelry that were typically yellow, red or black. Luz Claudio, PhD, professor of environmental medicine and public health at the Icahn School of Medicine at Mount Sinai said the findings suggest that parents should be cautious about plastic toys because they may contain harmful chemicals that may leech out easily when kids chew on them. “The stricter regulations that limit chemicals in toys do not apply retroactively to older toys,” Dr. Claudio added, who wasn’t involved in the study. As much as possible, parents can try to give kids alternatives to plastics, whether it’s plush toys or books to play with or frozen fruit wrapped in cheesecloth to teethe on, she said. As a mother, I understand that our children live in a plastic world and are surrounded by potentially hazardous chemicals,” Dr. Claudio said. “I think that if parents become aware of the issues, they will come up with alternatives to protect their children.” - Luz Claudio, PhD, Professor, Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai Learn more: https://www.newsmax.com/health/health-news/secondhand-toys-plastic- danger/2018/02/11/id/842680/ Additional coverage: Gulf Times http://www.gulf-times.com/story/581316/Second-hand-plastic-toys-may-be-harmful ARY News https://arynews.tv/en/second-hand-plastic-toys-risk-kids-study/

STAT News – February 12 Camels And Alpacas Have Special Antibodies. Now Researchers Can Make Them With Yeast — Andrew Joseph One of the biggest obstacles to obtaining a special and prized kind of antibody is that you need to know someone with a camel or alpaca. But given that these animals aren’t exactly hanging around many research centers – and that they’re not easy to work with – scientists have been developing synthetic ways of producing these antibodies. Researchers have discovered a new way of creating a synthetic library, one that uses yeast cells in a vial, as opposed to llamas at a farm, and that is being made available for free to other researchers. Already, the platforms creators have sent the vials – each of which can generate 500 million different versions of these antibodies – to about 40 other labs. Thomas M. Moran, PhD, professor of microbiology at the Icahn School of Medicine at Mount Sinai, who was not involved with developing the platform, said he was skeptical that the nanobodies would have strong enough affinity for their targets to be viable treatments. But he, too, said it could likely be a useful research tool. As part of their study, the researcher’s platform on two difficult-to-bind proteins called G-protein- coupled receptors. “That’s not easy,” Dr. Moran said. “That’s saying something.” - Thomas M. Moran, PhD, Professor, Microbiology, Icahn School of Medicine at Mount Sinai Learn more: https://www.statnews.com/2018/02/12/camels-alpacas-antibodies-yeast/

USA Today – February 6 Twins’ Ervin Santana To Miss Start Of The Season After Finger Surgery Minnesota Twins right-hander, Ervin Santana, will miss the start of the regular season after having surgery on his right middle finger. The Twins announced the 35 year old right-hander was operated on Tuesday at Mount Sinai Downtown by Charles Melone, MD, chief of hand surgery at Mount Sinai Beth Israel and professor of orthopaedic surgery at the Icahn School of Medicine at Mount Sinai, after experiencing discomfort during a bullpen session. Santana is expected to need ten to 12 weeks of rehabilitation before he can pitch in a major league game, which would keep him out of the rotation until at least mid-April. - Charles P. Melone Jr., MD, Chief, Hand Surgery, Mount Sinai Beth Israel, Professor, Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.usatoday.com/story/sports/mlb/2018/02/06/twins-santana-to-miss-start-of- season-after-finger-surgery/110165636/ Additional coverage: CBS Sports https://www.cbssports.com/mlb/news/twins-lose-ace-ervin-santana-for-10-12-weeks-due-to- finger-injury/

Romper – February 9 Who Plays Michelle Velez On ‘Grey’s Anatomy’? Candis Cayne Is The New Doctor In Town — Zakiya Jamal In a recent episode of Grey’s Anatomy all the doctors were preparing to compete in the new Grey Sloan Surgical Innovation Contest. Michelle Velez, is a trans woman who has a plan for a revolutionary surgery that can help all trans women. Candis Cayne got the inspiring role. The character of Michelle is inspired by the story of Hayley Anthony, a trans woman who helped Jess Ting, MD, surgical director at Mount Sinai’s Center for Transgender Medicine and Surgery, create a groundbreaking new procedure for vaginoplasty surgeries. - Jess Ting, MD, Surgical Director, Mount Sinai’s Center for Transgender Medicine and Surgery, Assistant Professor, Plastic and Reconstructive Surgery, Icahn School of Medicine at Mount Sinai Learn more: https://www.romper.com/p/who-plays-michelle-velez-on-greys-anatomy-candis-cayne-is- the-new-doctor-in-town-8171047

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - February 13, 2018 Date: Tuesday, February 13, 2018 1:49:56 PM Attachments: ATT00001.txt

In the News February 13, 2018

Medical Xpress – February 12 Researchers Discover Brain Pathway That Dissociates Opioid Addiction From Analgesia A newly-identified protein can be manipulated to make opioid painkillers effective at lower doses, while also muting the reward mechanism that leads to addiction. The protein, RGSz1, which is expressed in brain regions made that mediate analgesic responses, is part of an intracellular network that controls the pain-relieving effects of opioid analgesics like morphine, fentanyl, and methadone without increasing the risk of reward or dependence, according to a study conducted in mouse models at the Icahn School of Medicine at Mount Sinai and published in Proceedings of the National Academy of Sciences. "Our discovery that RGSz1 and RGSz1 regulated pathways can be targeted to promote analgesia is very exciting because it enables us to develop strategies for the use of low opioid doses for pain relief,” said Venetia Zachariou, PhD, associate professor in the Fishberg department of neuroscience, the department of pharmacological science for the Friedman Brain Institute and the Addiction Institute at the Icahn School of Medicine at Mount Sinai. - Venetia Zachariou, PhD, Associate Professor, The Fishberg Department of Neuroscience, The Department of Pharmacological Sciences, The Friedman Brain Institute, The Addiction Institute, Icahn School of Medicine at Mount Sinai Learn more: https://medicalxpress.com/news/2018-02-brain-pathway-dissociates-opioid-addiction.html Additional coverage: Science Newsline http://www.sciencenewsline.com/news/2018021223040070.html

AABB News – February 12 A Shifting Culture: Facilities Focus On Educating Physicians On Patient Blood Management — Elissa Fuchs Patient blood management (PBM) continues to gain traction, as more health care professionals subscribe to its patient care model and recognize its cost benefits. But culture change is never easy, and clinicians accustomed to ordering blood for certain cases may face challenges adjusting to more restrictive transfusion protocols. To expedite this process, facilities are now educating physicians on PBM principles – and encouraging them to embrace this discipline. The hope behind this approach is that informed clinicians will be motivated to reduce blood use when and where appropriate – and there will be a seismic shift in ordering and transfusion practices. “Facilities that want to have strong PBM programs need to get all clinicians on board, and a lot of education is necessary to make that happen,” said Mark Friedman, DO, medical director of the blood bank and transfusion service, director of the pathology residency program for the Mount Sinai Health System and associate professor of pathology at the Icahn School of Medicine at Mount Sinai, who has been involved in the implementation of PBM initiatives. - Mark T. Friedman, DO, Medical Director, Blood Bank and Transfusion Service, Director, Pathology Residency Program, Mount Sinai Health System, Associate Professor, Pathology, Icahn School of Medicine at Mount Sinai Learn more: No link available.

Medical News Today – February 13 Should All Women Get Screened For Ovarian Cancer? — Ana Sandoiu The United States Preventive Services Task Force (USPSTF) examined a wide range of previous studies in an effort to establish if screening for ovarian cancer reduces mortality risk for women who are not at hereditary risk of the condition. The results were published in the Journal of the American Medical Association (JAMA). The USPSTF concluded with "moderate certainty" that there are more disadvantages and potential harms to ovarian cancer screening than there are benefits. Therefore, they do not advise average-risk women to undergo such a procedure. Stephanie V. Blank, professor of gynecologic oncology, obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai and director of Women’s Health at Mount Sinai Chelsea Center said, “I agree that women who are not at increased genetic risk for ovarian cancer should not be offered ovarian cancer screening because we do not have an effective screening test.” She added, “However, if a woman has symptoms of ovarian cancer such as bloating, trouble eating, pelvic or abdominal pain, she should demand this testing.” - Stephanie V. Blank, MD, Professor in the Division of Gynecologic Oncology, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Director of Women's Health, Mount Sinai Chelsea Center Learn more: https://www.medicalnewstoday.com/articles/320915.php Additional coverage: HealthDay https://consumer.healthday.com/cancer-information-5/ovarian-cancer-news-104/ovarian- cancer-screening-still-ineffective-not-recommended-panel-731007.html Modern Healthcare http://www.modernhealthcare.com/article/20180213/NEWS/180219976 Daily Mail http://www.dailymail.co.uk/health/article-5386727/Screening-ovarian-cancer-NOT- recommended.html

Healthline – February 12 Brain Scans Could Change How We Diagnose Depression — Temma Ehrenfeld Brain scans may redefine depression and help doctors target treatment. Just as an electrocardiogram (EKG) shows the heart in action, a functional MRI shows the electrical activity of the brain. “We’ll see brain scan information help patients in three to five years,” said Helen Mayberg, MD, senior faculty of neurosurgery, neurology, psychiatry and neuroscience at the Icahn School of Medicine at Mount Sinai and director of the center for advanced circuit therapeutics at the Mount Sinai Health System. “We’re going to have precision psychotherapy the way we have precision cancer treatment.” For some illnesses, we have “” that can be seen on things such as a blood test. For other illnesses, doctors rely on a symptom history to make a diagnosis. The hope of the brain scan research is to find biomarkers for depression, and transform the field. “We’re trying to push the field so we can move away from the symptoms to the pathology,” Dr. Mayberg added. - Helen Mayberg, MD, Senior Faculty, Neurosurgery, Neurology, Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, Director, The Center for Advanced Circuit Therapeutics, Mount Sinai Health System Learn more: https://www.healthline.com/health-news/brain-scans-could-change-how-depression- diagnosed

Business Insider – February 13 Digital Health Briefing: Researchers Use AI To Automate Reading Radiology — Laurie Beaver & Ayoub Aouad Researchers at the Icahn School of Medicine at Mount Sinai have trained a machine learning algorithm to understand clinical concepts in a radiology report. The researchers used more than 96,000 radiologist reports to train the computer software, which encapsulated the variety of language used in reports, according to the study published in the journal Radiology. The study could lay the foundation for the training of artificial intelligence (AI) systems to read medical reports. The information in the reports can be turned into data, which can help AI provide clinical decision support for physicians. This is just the latest example of how providers and payers are turning to AI to improve workflow efficiency, mitigate unnecessary hospital visits, and better engage patients. - Eric Oermann, MD, Instructor, Neurosurgery, Icahn School of Medicine at Mount Sinai - John Zech, Medical Student, Icahn School of Medicine at Mount Sinai - Joshua Bederson, MD, Professor, System Chair, Neurosurgery, Mount Sinai Health System, Clinical Director, Neurosurgery Simulation Core Learn more: http://www.businessinsider.com/digital-health-briefing-digital-health-wins-big-in-new-us- spending-bill-dentists-can-use-ai-to-spot-tooth-decay-mobile-app-could-help-fight-opioid-crisis-2018-2

Psychiatry Advisor – February 13 Barriers To Mental Health Care Associated With Differences In Race, Insurance Among adults with serious psychological distress, whites and those with private insurance were significantly more likely than blacks to experience certain barriers to utilizing health care, according to a study published in Psychiatric Services. Judith Weissman, PhD, JD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai, and colleagues used data from the National Health Interview Survey to compare health care access and utilization among adults with serious psychological distress by race-ethnicity and gender in years surrounding implementation of the Affordable Care Act. The researchers found that the proportions of white and black adults with serious psychological distress were largest in the South. After adjusting for health coverage, sociodemographic characteristics, health conditions, region, and year, whites were more likely than blacks to report insufficient money for medications and mental health care and delays in care. - Judith Weissman, PhD, JD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.psychiatryadvisor.com/news/barriers-to-mental-health-care-linked-with- race/article/741997/

Tech Times – February 13 Eating Grapes Can Help Improve Symptoms Of Anxiety And Depression— Karen Tumbokon Grapes are packed with a bunch of nutrients and antioxidants that can improve one's overall health. However, a new study reveals compounds found in grapes can reduce symptoms of depression. Giulio Maria Pasinetti, PhD, Saunders professor of neurology and program director for the center for molecular integrative neuroresilience at the Icahn School of Medicine at Mount Sinai, conducted a study to find new ways to treat anxiety and depression. Dr. Pasinetti and his team discovered that bioactive dietary polyphenol preparation (BDPP), which is made of Concord grape juice, grape seed extract, and trans- resveratrol, was found to protect against mechanisms associated with depression. "The discovery of these new, natural grape-derived polyphenol compounds targeting cellular and molecular pathways associated with inflammation may provide an effective way to treat a subset of people with depression and anxiety, a condition that affects so many people,” said Dr. Pasinetti. - Giulio Maria Pasinetti, PhD, MD, Saunders Professor, Neurology, Program Director, Center for Molecular Integrative Neuroresilience, Icahn School of Medicine at Mount Sinai Learn more: http://www.techtimes.com/articles/220338/20180213/eating-grapes-can-help-improve- symptoms-of-anxiety-and-depression-says-study.htm Additional coverage: ThirdAge http://thirdage.com/researchers-find-that-grape-derived-compounds-may-promote-resilience- against-depression/

Healio – February 13 Patients Report Relief Of Ocular Symptoms After Xen Implantation – Michela Cimberle The Xen45 gel stent can provide long-term IOP reduction in patients with refractory glaucoma, while offering a more favorable safety profile and relief from multiple ocular symptoms, according to a poster presented at the American Academy of Ophthalmology meeting in New Orleans. “The improvement in symptoms is likely related to reduced medication use,” said lead author of the poster, Joseph Panarelli, MD, assistant professor of ophthalmology at the Icahn School of Medicine at Mount Sinai, associate residency program director and glaucoma fellowship director at the New York Eye and Ear Infirmary of Mount Sinai. “We wanted to evaluate whether symptoms improved with the decrease or discontinuation of medication use and whether or not the surgery itself caused a worsening of symptoms.” - Joseph Panarelli, MD, Assistant Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Associate Residency Program Director, Glaucoma Fellowship Director, New York Eye and Ear Infirmary of Mount Sinai Learn more: https://www.healio.com/ophthalmology/glaucoma/news/print/ocular-surgery- news/%7b71fc57f8-7fc1-483b-9deb-038274778e70%7d/patients-report-relief-of-ocular-symptoms-after- xen-implantation

Everyday Health – February 12 Hypothyroidism: How To Spot The Signs And How The Condition Is Diagnosed — Kristeen Cherney Hypothyroidism, also called low or underactive thyroid, is a relatively common condition that develops when your thyroid – a butterfly-shaped gland located at the bottom-front of your neck – doesn’t produce enough hormones. The most common hypothyroid symptoms are fatigue, cold intolerance, constipation, slower metabolism, and dry skin, while more surprising signs may be a slower heart rate, joint and muscle pain, and dry or puffy skin, said Gregory Dodell, MD, assistant clinical professor of medicine, endocrinology, diabetes, and bone disease at the Icahn School of Medicine at Mount Sinai. Some people might experience one symptom but not the others. The key to determining whether you might have hypothyroidism is the longevity of your symptoms. - Gregory Dodell, MD, Assistant Clinical Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai Learn more: https://www.everydayhealth.com/thyroid-conditions/hypothyroidism/warning-signs- symptoms-hypothyroidism/

Metro NY – February 12 How To Keep Your Heart Healthy This Valentine’s Day And Beyond — Sheila Dougherty Heart disease is an umbrella term with different diagnoses. “When most people talk about heart disease, they’re talking about coronary artery disease or coronary atherosclerosis,” said Dennis Finkielstein, MD, associate chairman of cardiology and director of ambulatory cardiology at Mount Sinai Beth Israel. In Manhattan, Dr. Finkielstein says more people are manifesting symptoms in their 40s. “We now have a whole group of people who are manifesting in their 30s. So, the notion that the disease is only of the middle-ages and above is absolutely untrue.” - Dennis Finkielstein, MD, Associate Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, Associate Chairman, Cardiology, Director, The Cardiovascular Diseases Fellowship, Director, Ambulatory Cardiology, Mount Sinai Beth Israel Learn more: https://www.metro.us/body-and-mind/health/heart-health

Urology Times – January 22 Low-Oxalate Diet More Beneficial Than Supplement A preliminary analysis of data from a randomized controlled trial supports the efficacy of a low-oxalate diet for reducing urinary oxalate excretion in patients with idiopathic hyperoxaluria, but shows little or no benefit for daily dietary supplementation with vitamin B6 mg/magnesium 400 mg or a diet- supplement combination. “To our knowledge, this is the first study designed to quantify and compare the effects of a dietary supplement, dietary changes, and both interventions for reducing urinary oxalate excretion, but evaluation of patient compliance with these treatments was a secondary objective,” said Mantu Gupta, MD, site chair of urology at Mount Sinai St. Luke’s and Mount Sinai West and director of the kidney stone center at Mount Sinai Hospital. - Mantu Gupta, MD, Site Chair, Urology, Mount Sinai St. Luke’s and Mount Sinai West, Director, The Kidney Stone Center, The Mount Sinai Hospital, Director, Endourology and Stone Disease, Kidney Stone Center, Mount Sinai Health System Learn more: http://urologytimes.modernmedicine.com/urology-times/news/low-oxalate-diet-more- beneficial-supplement?page=0,0

People Beating Cancer – February 12 Chronic Neuropathic Pain In Women After Breast Cancer Treatment — David Emerson Chemo-induced neuropathic pain and chronic pain after mastectomy are common side effects that can affect a breast-cancer survivor for life. “PMPS is a type of chronic neuropathic pain syndrome that can occur after breast surgery. It is typically associated with nerve fiber injury, but there may be other etiologies. It may be the result of trauma to the nerves during surgery or as a result of scar tissue,” explained Susan Boolbol, MD, associate professor of surgery at the Icahn School of Medicine at Mount Sinai and chief of breast surgery at Mount Sinai Beth Israel. Houman Danesh, MD, director of the division on integrative pain management at The Mount Sinai Hospital said, “Symptoms typical of neuropathic pain include burning, tingling, and lancinating pain in the area of surgery. This pain has been described as throbbing, aching or shooting. Although the pain can range from mild to severe, approximately ten percent of patients describe the pain as severe enough to significantly compromise their quality of life.” - Susan Boolbol, MD, Associate Professor, Surgery, Icahn School of Medicine at Mount Sinai, Chief, Breast Surgery, Mount Sinai Beth Israel - Houman Danesh, MD, Assistant Professor, Anesthesiology, Rehabilitative Medicine, Icahn School of Medicine at Mount Sinai, Director, Division of Integrative Pain Management, The Mount Sinai Hospital Learn more: https://peoplebeatingcancer.org/articlechronic-neuropathic-pain-women-after-breast-cancer- treatment/

Newsweek – February 12 Monkeys Killed Amid Panic Over Yellow Fever — Dana Dovey Monkeys in Brazil are being illegally killed for fear that they’re spreading yellow fever, but experts say this fear is misplaced because yellow fever is caused by a virus spread through the bite of infected mosquitos. Monkeys also contract the virus through mosquito bites but are unable to pass it to humans. Daniel S. Caplivski, MD, associate professor of medicine, infectious disease and director of the travel medicine program at the Icahn School of Medicine at Mount Sinai, emphasized that killing monkeys would do nothing to quell human outbreaks. “The short answer is no,” said Dr. Caplivski. “Yellow fever is a virus that is transmitted by mosquitoes.” - Daniel S. Caplivski, MD, Associate Professor, Medicine, Infectious Diseases, Director, Travel Medicine Program, Icahn School of Medicine at Mount Sinai Learn more: http://www.newsweek.com/yellow-fever-monkeys-brazil-panic-803493

Yahoo News – February 12 Even Gigi Hadid Gets Body-Shamed, Here’s Why It Needs To Stop — Korin Miller Gigi Hadid is the latest celebrity to speak out after being body-shamed. In a series of tweets, Hadid cited her battle with Hashimoto’s disease. “In general, body-shaming ‘devalues’ people and reduces their self- worth down to their outward appearance,” said Thomas Hildebrandt, PsyD, associate professor of psychiatry at the Icahn School of Medicine at Mount Sinai and chief of the division of eating and weight disorders at Mount Sinai Health System. He added if you’re struggling with an illness on top of that, it can make someone feel worse about themselves at a time when they may already be having difficulty with body changes they’re going through, leading to low self-esteem, depression, and eating problems. - Thomas Hildebrandt, PsyD, Associate Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Chief, Division of Eating and Weight Disorders, Mount Sinai Health System Learn more: https://www.yahoo.com/news/even-gigi-hadid-gets-body-shamed-heres-needs-stop- 221107510.html

Maine Public – February 12 Sony Apologizes For Making Fun Of Food Allergy In ‘Peter Rabbit’ — Mary Louise Kelly Sony Pictures is being criticized for a movie that didn’t seem all that controversial – “Peter Rabbit.” This update of the classic short stories by Beatrix Potter pits a group of rabbits led by the eponymous Peter against their nemesis, Mr. McGregor. In this version, Mr. McGregor is allergic to blackberries. In one scene, the rabbit pelts him with the fruit. One gets into his mouth, and he’s forced to use his EpiPen. Some of the families who have gone to see the movie and have kids with food allergies have left being upset. A survey by the Mount Sinai Health System found that about a quarter of children with food allergies are bullied, teased or harassed, sometimes with food as a weapon. - Mount Sinai Health System Learn more: http://mainepublic.org/post/sony-apologizes-making-fun-food-allergy-peter-rabbit Additional coverage: WCAI http://capeandislands.org/post/sony-apologizes-making-fun-food-allergy-peter-rabbit#stream/0 All Things Considered Radio – No link available

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - February 14, 2018 Date: Wednesday, February 14, 2018 1:58:22 PM Attachments: ATT00001.txt

In the News __ January 14, 2018

The Daily Telescope – February 14 Richard J. Martin, MD, Presented with the Albert Nelson Marquis Lifetime Achievement Award by Marquis Who’s Who — Jasmine Peters Marquis Who's Who, the world's premier publisher of biographical profiles, is proud to present Richard J. Martin, MD, professor of medicine, pulmonary, critical care and sleep medicine at the Icahn School of Medicine at Mount Sinai, with the Albert Nelson Marquis Lifetime Achievement Award. An accomplished listee, Dr. Martin celebrates many years of experience in his professional network, and has been noted for achievements, leadership qualities, and the credentials and successes he has accrued in his field. A widely regarded medical professional, Dr. Martin is known for his groundbreaking research into circadian rhythms and nocturnal asthma, as well as the role of bacterial infections in asthma. - Richard J. Martin, MD, Professor, Medicine, Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://dailytelescope.com/pr/richard-j-martin-md-presented-with-the-albert-nelson-marquis-lifetime-achievement-award-by-marquis- whos-who/74474

CBS Miami – February 14 Special Valentine’s Day Party Celebrates Life — Kenneth Craig Each year, about 40-thousand children are born with heart defects, sometimes needing surgeries and other procedures for the rest of their lives. Two- year-old Riley Ortiz was born with a rare and serious congenital heart defect. Doctors at Mount Sinai Hospital performed open heart surgery when she was just four months old. Riley is one of the thousands of children whose hearts have been mended by the pediatric cardiologists at the Kravis Children’s Hospital at Mount Sinai. Each Valentine’s Day the hospital, along with volunteers from Project Sunshine, treat them to a party. The celebration is in its 30th year and many of the families come back year after year just to say thank you. “It’s really the ultimate reward,” said Ira Parness, MD, professor of cardiology and chief of pediatric cardiology at the Icahn School of Medicine at Mount Sinai. “And when they come out the other end, it’s family and I have patients who tell me they love me,” added Dr. Parness. - Ira Parness, MD, Professor, Pediatrics, Cardiology, Chief, Division of Pediatric Cardiology, Icahn School of Medicine at Mount Sinai Learn more: http://miami.cbslocal.com/2018/02/14/special-valentines-day-party-celebrates-life/

Crain’s Health Pulse – February 14 Mount Sinai To Train Docs On Gender-Affirmation Surgery — Caroline Lewis Mount Sinai Health System is planning a three-day event in April that will use live gender-affirmation surgeries to train health care professionals treating transgender patients. The procedures that clinicians will observe include vaginoplasty, breast augmentation, facial feminization, metoidioplasty (female-to-male surgery) and top surgery. The surgeries will be performed in operating rooms within the hospital and then broadcast into the Stern auditorium. "There's a much greater demand now for these kinds of procedures than there is a supply of quality personnel to provide them," said Barbara Warren, director of LGBT programs and policies at Mount Sinai's Office of Diversity and Inclusion. Gender-affirmation surgeries require trained professionals throughout the continuum of care, including mental health professionals, social workers, primary care doctors, clerical staff and nurses, said Warren. In New York, demand for gender-affirmation surgery has risen since Medicaid agreed to cover it in 2015. Mount Sinai has 500 patients queued up for a gender-affirmation procedure of some kind. Mount Sinai will charge for the training sessions, for which participants can get continuing-medical-education credits. It also received funding from the state Health Department, which views gender-affirmation surgery as part of its HIV-prevention agenda. "The more people get to fully be themselves and get the medical care they need, the more incentive they have to take care of themselves and avoid issues like HIV infection," Warren said. - Barbara Warren, PsyD, Director, LGBT Programs and Policies, Mount Sinai’s Office of Diversity and Inclusion Learn more: http://www.crainsnewyork.com/article/20180214/PULSE/180219956/citymd-to-buy-12-clinic-li-chain (Subscription required)

Orthopedics This Week – February 13 Back Injuries In Females Linked To Poor Diet — Elizabeth Hofheinz Scientists from the Leni & Peter W. May Department of Orthopaedics at the Icahn School of Medicine at Mount Sinai examined the effect of a diet high in advanced glycation end products on the spine, something that has never been done before. Svenja Illien-Junger, PhD, assistant professor of orthopaedics at the Icahn School of Medicine at Mount Sinai, and co-author of the study said, “Diabetes is a known risk factor for back pain related to the spine and in our lab we asked exactly how diabetes could cause spinal problems. Our results suggest that poor diet could potentially cause increased spinal pathologies. We recommend that young women, especially if they are diabetic, should be aware of their diet.” - Svenja Illien-Junger, PhD, Assistant Professor, Orthopaedics, Icahn School of Medicine at Mount Sinai Learn more: https://ryortho.com/breaking/back-injuries-in-females-linked-to-poor-diet/

Oncology Times – February 13 Subcutaneous Daratumumab Potential Game Changer For Multiple Myeloma — Peter M. Goodwin Subcutaneous administration of the anti-CD38 monoclonal antibody daratumumab could make it possible for more patients to receive this emerging therapy more easily for their advanced or recently diagnosed multiple myeloma, according to research reported at the 2017 American Society of Hematology Annual Meeting. “It's one of those rare things in medicine where you have a drug that seems to be safer, with lower rates of infusion reaction, seems to be more convenient, and seems to have comparable efficacy,” said study author Ajai Chari, MD, associate professor of medicine, hematology, medical oncology, director of clinical research in the multiple myeloma program and associate director of clinical research at the Mount Sinai Cancer Clinical Trials Office at the Icahn School of Medicine at Mount Sinai. “So I think those things speak for themselves. These are really exciting results and I think it speaks to the reason why there are four phase III studies going on using this formulation.” - Ajai Chari, MD, Associate Professor, Medicine, Hematology, Medical Oncology, Director, Clinical Research in the Multiple Myeloma Program, Associate Director, Clinical Research, Mount Sinai Cancer Clinical Trials Office, Icahn School of Medicine at Mount Sinai Learn more: https://journals.lww.com/oncology-times/Fulltext/2018/02200/Subcutaneous_Daratumumab_Potential_Game_Changer.18.aspx

Daily Mail – February 13 Transgender Woman Becomes First In The World To Breastfeed Exclusively For Six Weeks — Mia De Graaf A transgender woman has become the first in the world to exclusively breastfeed her baby despite not giving birth nor undergoing gender- reassignment surgeries. The 30-year-old woman, told doctors at Mount Sinai’s Center for Transgender Medicine and Surgery that her partner was pregnant but did not wish to breastfeed, and she hoped to try instead. For three-and-a-half months before the birth, the woman was put on a dose of hormone replacement therapy, as well as breast pumping, until she could produce eight ounces of milk a day. The patient’s doctor, Tamar Reisman, MD, assistant professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai said the milestone was a breakthrough for transgender medicine. “We are happy that the patient shared her experience with us, and we are happy to help our patients build happy, healthy, transgender families.” Dr. Reisman said it is possible the mother could have produced breastmilk with a breast pump alone, and that the domperidone was merely supplementary. - Tamar Reisman, MD, Assistant Professor, Medicine, Endocrinology, Diabetes, and Bone Disease, Icahn School of Medicine at Mount Sinai - Zil Goldstein, MSN, Assistant Professor, Medical Education, Icahn School of Medicine at Mount Sinai, Program Director, The Center for Transgender Medicine and Surgery, The Mount Sinai Health System Learn more: http://www.dailymail.co.uk/health/article-5387035/Transgender-woman-world-breastfeed.html Additional coverage: Independent http://www.independent.co.uk/life-style/health-and-families/transgender-woman-breastfeed-first-world-milk-baby-new-york-tamar- reisman-zil-goldstein-mount-sinai-a8209946.html New Scientist https://www.newscientist.com/article/2161151-transgender-woman-is-first-to-be-able-to-breastfeed-her-baby/ The Times https://www.thetimes.co.uk/article/transgender-woman-breastfeeds-baby-qjtzrl6g8 The Inquisitr https://www.inquisitr.com/4785788/transgender-woman-becomes-first-to-breastfeed-her-baby-according-to-new-scientist/ Yahoo News https://in.style.yahoo.com/transgender-woman-becomes-first-world-113855059.html

CBS New York – February 14 Complete Flu Resource Guide — Dr. Max Gomez There’s no cure for the common cold and the flu only responds to antiviral medications if they are taken within the first 48 hours of symptoms. Regardless of symptoms, people should be mindful of the decision they make with over-the-counter drugs. “OTC meds can handle almost all symptoms, whether it’s a cough or a cold or influenza,” said Peter Shearer, MD, assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai and medical director of the emergency department at the Mount Sinai Hospital. “A lot of meds are mixtures, combos of three of four meds. I steer people away from those into what exactly they need.” Dr. Shearer added that tea with some honey is a decent home remedy for a cough and sore throat. Other symptoms can usually be handled at the drugstore, but it’s important to read those medicine labels carefully. In children and the elderly, Dr. Shearer said it’s important to watch out for confusion or altered mental status, which could be a sign of something more than just a viral infection which would require a trip to the emergency room - Peter Shearer, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Emergency Department, The Mount Sinai Hospital Learn more: http://newyork.cbslocal.com/2018/02/14/flu-resources/

U.S. News & World Report – February 13 Ovarian Cancer Screening Still Ineffective And Not Recommended — Robert Preidt Screening for ovarian cancer is not recommended for women with no signs or symptoms of the disease, according to newly released guidelines from the U.S. Preventive Services Task Force. However, the task force recommendation does not apply to women at high risk for ovarian cancer. That includes those with a BRCA gene mutation that is associated with hereditary breast and ovarian cancer. Stephanie V. Blank, professor of gynecologic oncology, obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai and director of Women’s Health at Mount Sinai Chelsea Center said she generally agrees with the task force recommendations “because we do not have an effective screening test.” However, she said, “Because screening for ovarian cancer is not effective, it is extremely important that women be aware of the symptoms of ovarian cancer and advocate for themselves.” - Stephanie V. Blank, MD, Professor in the Division of Gynecologic Oncology, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Director of Women's Health, Mount Sinai Chelsea Center Learn more: https://health.usnews.com/health-care/articles/2018-02-13/ovarian-cancer-screening-still-ineffective-not-recommended-panel Additional coverage: MedPage Today https://www.medpagetoday.com/obgyn/generalobgyn/71124 The Philadelphia Inquirer http://www.philly.com/philly/health/topics/HealthDay731007_20180213_Ovarian_Cancer_Screening_Still_Ineffective__Not_Recommended__Panel.html Doctors Lounge https://www.doctorslounge.com/index.php/news/hd/78417 UPI https://www.upi.com/Health_News/2018/02/13/Panel-Ovarian-cancer-screening-ineffective-not-recommended/9461518542203/ Healthline https://www.healthline.com/health-news/ovarian-cancer-screening-not-recommended-fo-all-women Everyday Health https://www.everydayhealth.com/ovarian-cancer/living-with/screening-asymptomatic-women-without-genetic-risk/ Cancer Compass https://cancercompass.com/cancer-news/article/60746.htm

CBS New York – February 14 Task Force Says Most Women Don’t Benefit From Screening For Ovarian Cancer — Dr. Max Gomez Early screening and detection normally means improved survival, but screening tests for ovarian cancer aren’t very specific and that leads to a lot of false positives, which means interventions and surgeries that themselves carry risks. Ellen Stein, an ovarian cancer patient at Mount Sinai, was a normal, very active and apparently healthy 75-year-old, until one day she became extremely bloated as if she was eight months pregnant. That was the first sign that Ellen had stage three ovarian cancer. Fortunately, she saw her doctor right away for surgery and chemotherapy, but most women are not as lucky. “Ovarian cancer has a very high mortality rate and that is because 75 to 80 percent of the cancer is diagnosed at a very advanced stage, which would be stage three or four,” said Valentin Kolev, MD, assistant professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai. Screening for ovarian cancer is not recommended for women with no signs or symptoms of the disease, according to newly released guidelines from the U.S. Preventive Services Task Force. However, the task force recommendation does not apply to women at high risk for ovarian cancer. - Valentin Kolev, MD, Assistant Professor, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: http://newyork.cbslocal.com/2018/02/13/ovarian-cancer-screening/amp/

OncLive – February 14 Expert Discusses Docetaxel Versus Abiraterone In Hormone-Sensitive Prostate Cancer — Caroline Seymour The management of metastatic hormone-sensitive prostate cancer continues to evolve as new findings emerge, such as results from the LATITUDE and CHAARTED studies. William K. Oh, MD, professor of medicine, hematology, medical oncology and urology, chief of the division of hematology and medical oncology, and associate director of clinical research at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, discussed treatment with abiraterone versus docetaxel in patients with prostate cancer, other remaining questions in the field, and what role immunotherapy is poised to play. “One of the biggest developments in the treatment of advanced prostate cancer over the past several years has been the management of metastatic hormone-sensitive prostate cancer,” he said. - William K. Oh, MD, Professor, Medicine, Hematology, Medical Oncology, Urology, Chief, Division of Hematology and Medical Oncology, Associate Director, Clinical Research, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai Learn more: http://www.onclive.com/web-exclusives/expert-discusses-docetaxel-versus-abiraterone-in-hormonesensitive-prostate-cancer

High Times – February 13 Can Marijuana Treat Postpartum Depression? — Burgess Powell Cannabis is becoming an increasingly common treatment for depression. But is marijuana safe to use while breastfeeding? In short, smoking of any kind is inadvisable while pregnant or breastfeeding. Yasmin Hurd, PhD, professor of psychiatry, neuroscience, pharmacology, systems therapeutics at the Icahn School of Medicine at Mount Sinai, chair of Ward-Coleman translation neuroscience, and director of the Center for Addictive Disorders at the Mount Sinai Health System said, “Even early in development, marijuana is changing critical circuits and neurotransmitting receptors.” The consequences of transmitting THC to a baby can be significant and long-term. You could argue that most of the research is about THC transfer during pregnancy. But infants can also absorb THC through breast milk and we can assume, for now, that similar risks exist. -Yasmin Hurd, PhD, Professor, Psychiatry, Neuroscience, Pharmacology, Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Chair, Ward-Coleman Translational Neuroscience, Director of the Center for Addictive Disorders, Mount Sinai Health System Learn more: https://hightimes.com/women/marijuana-postpartum-depression/

Diagnostic & Interventional Cardiology – February 13 New Pacemaker Technologies — Dave Fornell In early 2016, the U.S. Food and Drug Administration approved the Medtronic Micra device, the first leadless, catheter-implanted pacemaker approved in the United States. It is the world’s smallest pacemaker at 0.8 cc in size. Micra has four self-expanding nitinol hooks that extend as it is unsheathed from its delivery catheter. These act as an anchor, hooking into the trabeculation at the apex of the right ventricle. “The problem with regular pacemakers is the wire that goes to the heart, because as the heart is beating and the wire has all this motion, over the course of time you can hear breaks in the wires. The idea with a leadless pacemaker is that you take the whole wire out of the equation,” said Vivek Reddy, MD, MS, professor of medicine and cardiology at the Icahn School of Medicine at Mount Sinai and director of cardiac arrhythmia services for the Mount Sinai Health System. Dr. Reddy said as a single-chamber pacing system, both the Micra and the Nanostim perform very well according to clinical trial data. Medicare is now reimbursing use of these devices. - Vivek Reddy, MD, MS, Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, Director, Cardiac Arrhythmia Services, Mount Sinai Health System Learn more: https://www.dicardiology.com/article/new-pacemaker-technologies

Slate Magazine – February 13 How Does A Gender-Reassignment Surgeon Work? — Jacob Brogan “Transgender surgery used to be a specialty that lived on the margins of the medical world,” said Jess Ting, MD, surgical director of Mount Sinai’s Center for Transgender Medicine and Surgery, assistant professor of plastic and reconstructive surgery at the Icahn School of Medicine at Mount Sinai. That’s changing, thanks in part to the efforts of Mount Sinai’s Center for Transgender Medicine and Surgery. Dr. Ting and his team have performed more than 350 transgender surgeries since March 2016. More recently, they created a fellowship program to help train surgeons in the field. Along the way, Dr. Ting has helped pioneer new surgical procedures and techniques. That, he said, makes his work exciting and sometimes a little scary: “It’s a unique opportunity to be doing a specialty that is so underdeveloped, to be entering the field really in its infancy,” said Dr. Ting. “There are just not that many jobs where you can get up in the morning and say, today I’m going to change someone’s life. That’s the most rewarding part of what I get to do every day. It’s a privilege and a joy. - Jess Ting, MD, Surgical Director, Mount Sinai’s Center for Transgender Medicine and Surgery, Assistant Professor, Plastic and Reconstructive Surgery, Icahn School of Medicine at Mount Sinai Learn more: https://slate.com/podcasts/2018/02/dr-jess-ting-a-plastic-surgeon-who-specializes-in-transgender-surgery-at-mt-sinai-hospital-in-new- york-city.html?via=recirc_recent

New Republic – February 14 Did Flint’s Water Crisis Damage Kids’ Brains? — Emily Atkin Kids in the lead-poisoned city of Flint, Michigan have become increasingly bad at reading since the water crisis began in 2014. Even if lead was removed in 2016, the effects of lead on a child’s brain wouldn’t have vanished, said Philip Landrigan, MD, MSc, professor of environmental medicine and public health, pediatrics, and dean for global health at the Icahn School of Medicine at Mount Sinai. Dr. Landrigan is a global expert on lead and one of the first scientists to show how lead causes brain damage in children. “Even the very lowest levels of exposure, we know that lead erodes a child’s IQ, shortens attention span, and disrupts their behavior,” he said. “We know when we do follow-up studies that children exposed when they were kids are more likely to be dyslexic, have behavioral problems, and get in trouble with the law. There’s no question about that.” In addition, lead exposure tends to be chronic, because exposure to tainted paint or water tends to be long-term. Dr. Landrigan said it’s likely that an eight-year-old child with lead in her blood has carried it for years. - Philip Landrigan, MD, MSc, Professor, Environmental Medicine and Public Health, Pediatrics, Dean for Global Health, Icahn School of Medicine at Mount Sinai Learn more: https://newrepublic.com/article/147066/flints-water-crisis-damage-kids-brains

MedPage Today – February 13 Parents Angry Over Food Allergy Bullying In Movie ‘Peter Rabbit’ — Salynn Boyles Sony Pictures is being met with a firestorm of criticism from furious parents over a scene in its newly released, eponymous movie in which Peter and his friends pelt their human nemesis, Mr. McGregor, with blackberries – knowing that he is severely allergic. When one lands in his mouth, he must resort to self-injecting epinephrine. A 2010 study by Scott Sicherer, MD, professor of allergy and immunology and chief of the division of allergy and immunology at the Jaffe Food Allergy Institute at the Icahn School of Medicine at Mount Sinai, found bulling those with food allergies was common among children and even adults. One-quarter of children surveyed in that study reported a history of being bullied because of their food allergies, and more than half reported that the harassment included a physical event, such as having an allergen thrown or waved at them. - Scott Sicherer, MD, Professor, Pediatrics, Allergy and Immunology, Chief, Division of Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/allergyimmunology/allergy/71126

Teen Vogue – February 13 What To Know About Eye Worms — Kastalia Medrano Abby Beckley of Grants Pass, Oregon, was on an extended trip aboard a commercial fishing boat, when following days of migraines and inexplicable irritation in her left eye, she went to dig out what she thought might be an eyelash and instead discovered a worm. Doctors identified them as species Thelazia gulosa. “Having other kinds of worms in the eye is not completely out of the blue,” said Avnish Deobhakta, MD, assistant professor of vitreoretinal surgery and ophthalmology at the Icahn School of Medicine at Mount Sinai. “It is unusual for the United States, but it’s not unusual if you’ve ever worked with international patients, particularly in Africa and in tropical areas.” He added, “There’s no way for someone to know the species and you may scratch your eye trying to remove it. I would say if you think you’ve been infected with a worm, come to the ophthalmologist.” - Avnish Deobhakta, MD, Assistant Professor, Vitreoretinal Surgery, Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, Icahn School of Medicine at Mount Sinai Learn more: https://www.teenvogue.com/story/what-to-know-about-eye-worms

Live Science – February 13 Japanese Olympian Suspended: How Widespread Is Olympic Doping? — Brandon Specktor Japanese short-track speed skater Kei Saito became the first Olympic athlete to be suspended from the 2018 Winter Games due to doping allegations. Saito's suspension is the first to occur during the 2018 games, but it's hardly the first scent of doping-related scandal this winter. Just days before Saito's expulsion, the CAS ruled to uphold the bans on 47 Russian athletes and coaches implicated in a state-sponsored doping program during the 2014 Winter Olympics in Sochi, Russia. "As evidenced by athletes who were previously thought to be clean and weren't, people are willing and able to dope at large scale," said Thomas Hildebrandt, PsyD, associate professor of psychiatry at the Icahn School of Medicine at Mount Sinai and chief of the division of eating and weight disorders at the Mount Sinai Health System. "I think we have to assume that the Russians got caught but other programs are doing similar things. And I think it would be foolish of anyone to think otherwise." - Thomas Hildebrandt, PsyD, Associate Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Chief, Division of Eating and Weight Disorders, Mount Sinai Health System Learn more: https://www.livescience.com/61747-how-widespread-olympic-doping.html

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - February 15, 2018 Date: Thursday, February 15, 2018 12:11:47 PM Attachments: ATT00001.txt

In the News February 15, 2018

Queens Gazette – February 14 Mount Sinai Queens’ Presentation At UCCA Breakfast Caryn A. Schwab, executive director of Mount Sinai Queens, provided the participants at the UCCA Legislative Breakfast with an update on the hospital’s expansion project, and corresponding new programs. “We are overjoyed with the appearance of Mount Sinai Queens, and the modern, state-of-the-art facilities that we have built,” said Schwab. “However, the real difference to the community is in the physicians and staff we are able to attract, and the programs we are able to implement in the new facility.” Schwab discussed Mount Sinai Queens’ innovative interventional radiology program. Interventional radiology uses a micro-incision to thread a catheter into the body to deliver image-guided treatment. She also announced five Mount Sinai multi-specialty practices in Queens, where the physicians are all on the faculty of the Icahn School of Medicine at Mount Sinai: two in Long Island City, one in Jackson Heights, one in Forest Hills, and the largest, Mount Sinai Doctors Queens, in the Mount Sinai Queens Pavilion adjacent to the Hospital. - Caryn A. Schwab, Executive Director, Mount Sinai Queens Learn more: http://www.qgazette.com/news/2018-02-14/Features/Mount_Sinai_Queens_Presentation_At_UCCA_Breakfast.html

The Guam Daily Post – February 14 Studies Examine Important Matters Of The Heart — Pam Eastlick Researchers at Mount Sinai St. Luke’s found that routine mammography also may be a useful tool to identify women at risk for heart disease, potentially allowing for earlier intervention. Data from this study show, for the first time, a link between the amount of calcium in the arteries of the breast and the level of calcium buildup in the coronary arteries. Coronary arterial calcification, or CAC, is considered a very early sign of cardiovascular disease. Seventy percent of the women who had evidence of breast arterial calcification on their mammogram also were found to have CAC as shown on a noncontrast CT scan of the chest. The researchers say this information is available on every mammogram, with no additional cost or radiation exposure, and their research suggests breast arterial calcification is as good as the standard risk factor-based estimate for predicting risk. The more breast arterial calcification a women has, the more likely she is to have calcium in her heart's arteries as well and the link should not be ignored. - Mount Sinai St. Luke’s Learn more: https://www.postguam.com/forum/featured_columnists/studies-examine-important-matters-of-the- heart/article_2f00d194-113d-11e8-b1bf-77e8770e118e.html

The Guardian – February 14 Transgender Woman Able To Breastfeed In First Documented Case — Jessica Glenza A 30-year-old transgender woman has been able to breastfeed her child, the first ever case of induced lactation in a transgender woman to be documented in academic literature. Tamar Reisman, MD, assistant professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai, one of the doctors who reported the case said, “Transgender medicine is becoming part of mainstream medicine. We’re getting more evidence-based data, we’re getting more standardized care, and we’re getting more reproductive options.” The transgender woman went to doctors when her partner was five months pregnant. She said her partner did not want to breastfeed the couple’s child, so she hoped to take on the responsibility. The patient took a gradually increasing regimen of the female hormones progesterone and estradiol, stimulated her chest with a breast milk pump, and took domperidone, a nausea medication known to increase milk production. Dr. Reisman said the case has also attracted questions about whether men could now breastfeed. “That, implicitly, is saying that you see transgender women as cisgender men, which is transphobic,” she said. - Tamar Reisman, MD, Assistant Professor, Medicine, Endocrinology, Diabetes, and Bone Disease, Icahn School of Medicine at Mount Sinai - Zil Goldstein, MSN, Assistant Professor, Medical Education, Icahn School of Medicine at Mount Sinai, Program Director, The Center for Transgender Medicine and Surgery, The Mount Sinai Health System Learn more: https://www.theguardian.com/science/2018/feb/14/transgender-woman-breastfeed-health Additional coverage: The Blaze https://www.theblaze.com/news/2018/02/14/transgender-woman-used-experimental-treatments-to-become-first-to- breastfeed-a-baby The Washington Post https://www.washingtonpost.com/news/to-your-health/wp/2018/02/14/how-a-transgender-woman-breast-fed- her-baby/?utm_term=.3857e53bc783 New York Post https://nypost.com/2018/02/14/transgender-woman-becomes-first-to-breastfeed-baby/ Chicago Tribune http://www.chicagotribune.com/lifestyles/health/ct-transgender-breast-feeding-20180215-story.html Science Alert https://www.sciencealert.com/this-is-how-a-transgender-woman-was-able-to-breast-feed-her-baby

Mass Device – February 8 Penumbra Touts Non-Inferiority In Compass Aspiration Thrombectomy Trial — Fink Densford Penumbra released results from the Compass Trial of its aspiration thrombectomy system designed to treat acute ischemic stroke, touting that the system was shown to be non-inferior to stent retrievers. Results from the trial were presented at the International Stroke Conference. “The primary outcome was demonstrating non-inferiority in clinical outcome between the patients, and it’s the first trial designed specifically to access clinical outcome in non-inferiority between these two cohorts. The results demonstrate clearly non-inferior outcomes, with 52 percent of the aspiration first cohort achieving independence and 49 percent of the second cohort demonstrating independence, and the persistence of non-inferiority was consistent across multiple sensitivity analyses,” said lead investigator, J Mocco, MD, MS, professor of neurosurgery at the Icahn School of Medicine at Mount Sinai, director of the cerebrovascular center at The Mount Sinai Hospital and vice chair of neurosurgery for the Mount Sinai Health System. “There is clearly a dire need for us to prove our ability to get patients these important therapies, and it’s better if Compass’ results help to step along that path – that’d certainly be a tremendous win,” Dr. Mocco said. - J Mocco, MD, MS, Professor, Neurosurgery, Icahn School of Medicine at Mount Sinai, Director, The Cerebrovascular Center, Mount Sinai Hospital, Vice Chair, Neurosurgery, The Mount Sinai Health System Learn more: https://www.massdevice.com/penumbra-touts-non-inferiority-compass-aspiration-thrombectomy-trial/

ALN Magazine – February 14 Grape Compound Protects Against Depression, Mouse Research Reveals — Elizabeth Doughman Natural compounds found in grapes could ward off stress-induced depression, according to new research found in Nature Communications. Scientists at the Icahn School of Medicine at Mount Sinai conducted an extensive analysis of two new grape-derived compounds, dihydrocaffeic acid (DHCA) and malvidin-3’-O-glucoside (Mal-gluc). The research team found that a bioactive dietary polyphenol product that included a select Concord grape juice, a select grape seed extract, and trans-resveratrol effectively treated stress-induced depression in mice. "We hope to translate our findings into a clinical setting, where we believe the treatment could effectively decrease difficult to treat symptoms associated with depression by targeting mechanisms of inflammation in a subset of patients who are refractive to current treatment options," said Giulio Maria Pasinetti, PhD, MD, Saunders professor of neurology, and program director for the center of molecular integrative neuroresilience at the Icahn School of Medicine at Mount Sinai. - Giulio Maria Pasinetti, PhD, MD, Saunders Professor, Neurology, Program Director, Center for Molecular Integrative Neuroresilience, Icahn School of Medicine at Mount Sinai Learn more: https://www.alnmag.com/news/2018/02/grape-compound-protects-against-depression-mouse-research-reveals

NBC News – February 15 Here’s Why It’s So Hard To Make A Better Flu Vaccine — Maggie Fox Every year, flu kills between 12,000 and 56,000 people, the CDC says. This year is shaping up to be on the high end of that range. That’s why teams of scientists are working on what’s called a universal flu vaccine. The hope is to develop a formulation that will recognize something a little deeper than just the “face” of the flu virus — something that doesn’t change from one virus to another and that doesn’t mutate over time. Peter Palese, PhD, professor and chair of microbiology and professor of medicine and infectious diseases at the Icahn School of Medicine at Mount Sinai, has a team working on a vaccine that goes after on unchanging target. One of influenza’s most prominent surface protein is hemagglutinin — the “H” in a flu virus’s name. It’s a mushroom-shaped structure and while the “cap” of the flu mushroom is both easily seen and also changeable, the stem is less visible and also mutates less. Dr. Palese’s lab is focusing on ways to stimulate the immune system to recognize the stem or stalk of the hemagglutinin protein – the equivalent of tweaking facial recognition technology so look for the overall shape of someone's face, or the distance between the eyes. - Peter Palese, PhD, Professor, Chair, Microbiology, Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.nbcnews.com/health/health-news/here-s-why-it-s-so-hard-make-better-flu-n848081

Medscape – February 14 ‘No’ To Ovarian Cancer Screening: Harm Outweigh Benefits — Liam Davenport Women should not undergo screening for ovarian cancer if they do not have signs or symptoms of the disease, as it does not improve survival but may expose women unnecessarily to surgical complications. This is the final guidance from the US Preventive Services Task Force, published in JAMA. Stephanie V. Blank, MD, professor of gynecologic oncology, obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai and director of women’s health at Mount Sinai Chelsea Center, who was not involved in developing the recommendations, agreed that there is a lack of effective tests for the disease. "In the general population, ovarian cancer is a relatively rare disease, and the specificity of our current tests is not acceptable," she said in a statement. "False positives in ovarian cancer screening can result in unindicated surgeries. - Stephanie V. Blank, MD, Professor in the Division of Gynecologic Oncology, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Director of Women's Health, Mount Sinai Chelsea Center Learn more: https://www.medscape.com/viewarticle/892673 Additional coverage: Cure Today https://www.curetoday.com/articles/harms-outweigh-benefits-from-screening-women-at-average-risk-for-ovarian-cancer

HealthDay – February 14 One Hidden Culprit Behind Weight Gain: Fruit Juice — Dennis Thompson Fruit juice isn't doing any favors for your waistline, a new study reports. People who drink a small glass of fruit juice daily can expect to steadily gain a bit of weight over the years, according to data from a long-term study of women's health. Sugary fruit juice is a contributing factor to obesity, said Reshmi Srinath, MD, assistant professor of medicine, endocrinology, diabetes and bone disease, and director of the weight and metabolism management program at the Icahn School of Medicine at Mount Sinai, but it’s “heard to pinpoint as a single culprit” responsible for weight gain. "Generally, the association is with the pattern of healthy eating and healthy lifestyle," Dr. Srinath added. Those who eat fresh fruit are generally having a healthier or more active lifestyle than those who are drinking juice. “I would say limit juice, especially through childhood, because those patterns can continue into adulthood.” - Reshmi Srinath, MD, Assistant Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Director, Weight and Metabolism Management Program, Icahn School of Medicine at Mount Sinai Learn more: https://consumer.healthday.com/vitamins-and-nutrition-information-27/food-and-nutrition-news-316/one-hidden- culprit-behind-weight-gain-fruit-juice-731105.html Additional coverage: Medical Xpress https://medicalxpress.com/news/2018-02-hidden-culprit-weight-gain-fruit.html The Philadelphia Inquirer http://www.philly.com/philly/health/topics/HealthDay731105_20180214_One_Hidden_Culprit_Behind_Weight_Gain__Fruit_Juice.html Drugs.com https://www.drugs.com/news/one-hidden-culprit-behind-weight-gain-fruit-juice-68698.html? utm_source=ddc&utm_medium=rss&utm_campaign=One+Hidden+Culprit+Behind+Weight+Gain%3A+Fruit+Juice Doctors Lounge https://www.doctorslounge.com/index.php/news/hd/78446 NewsMax Health https://www.newsmax.com/health/health-news/weight-gain-fruit-juice-culprit/2018/02/15/id/843525/

WADO AM Radio – February 14 Symptoms That Tell You That You May Be Suffering From Some Heart Disease Johanna Contreras, MD, assistant professor of medicine and cardiology at the Icahn School of Medicine at Mount Sinai spoke about the importance of heart care. Exercising and controlling blood pressure can help prevent heart or brain attacks. Chest pains, shortness of breath, swelling of the legs and resistance to physical activity are all symptoms that tell you to go to the doctor. - Johanna Contreras, MD, Assistant Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai Learn more: https://www.univision.com/nueva-york/wado-am/nueva-york/wxtv/sintomas-que-le-indican-que-puede-estar-sufriendo- de-alguna-enfermedad-del-corazon-video

Tonic – February 14 Menthol Cigarettes Could Be Even Worse Than Regular Cigarettes — Jessica Migala New Jersey is taking steps to become the first state to ban the sale of menthol cigarettes. Menthol, the compound in plants like peppermint that impart a minty taste, has been added to cigarettes since the 1920s. Problem is, because of the flavor and the cooling sensation you get from the menthol, some smokers think they’re a safer alternative than regular cigarettes. “All of these cigarettes cause cancer. Period,” said Raja Flores, MD, Steven and Ann Ames professor in thoracic surgery, director of the thoracic surgical oncology program at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai and system chair of thoracic surgery for the Mount Sinai Health System. “Menthol will make you inhale more. The more you smoke, the greater your chances of getting cancer,” Dr. Flores said. - Raja Flores, MD, Steven and Ann Ames Professorship in Thoracic Surgery, Director, Thoracic Surgical Oncology Program, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, System Chair, Thoracic Surgery, Mount Sinai Health System Learn more: https://tonic.vice.com/en_us/article/8xdx7k/are-menthol-cigarettes-worse

Brooklyn Reporter – February 14 Newest ‘Medcast Plus’ Episode Tackles Diabetes— Jaime DeJesus This month’s ‘Medcast Plus,’ a television program aimed at informing Brooklynites about various health issues with doctors medical professions as featured guests, focuses on diabetes and how patients can treat the disease ahead of time. Iraklii Buziashvili, MD, an endocrinologist at Mount Sinai Brooklyn, discussed the importance of treating diabetes as well as other illnesses. “If any of your relatives have diabetes, especially one of both of your parents, that’s probably one of the biggest reasons to get checked and then do something to lower the risk. Eat healthier, lose weight or increase physical activity,” said Dr. Buziashvili. - Iraklii Buziashvili, MD, Endocrinologist, Mount Sinai Brooklyn Learn more: http://brooklynreporter.com/story/newest-medcast-plus-episode-tackles-diabetes/

Self Magazine – February 14 Nine Mistakes You’re Making When You Moisturize Your Face — Jenn Sinrich The best moisturizer is the one that fits your own skin’s needs. “Just because your best friend likes the feel of a particular product, does not mean it will work well for you,” said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at The Mount Sinai Hospital. “With so many products on the market, you can select the ideal formulation for your preference – gel, creams, lotions, ointments and foams can all be effective.” The key is to know which ingredients will best address your individual skin concerns. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.self.com/story/how-to-moisturize-face

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - February 16, 2018 Date: Friday, February 16, 2018 2:08:34 PM Attachments: ATT00001.txt

In the News February 16, 2018

The New York Times – February 15 Transgender Woman Breast-Feeds Baby After Hospital Induces Lactation — Ceylan Yeginsu When a transgender woman told doctors at the Mount Sinai Hospital that she wanted to breast feed her pregnant partner’s baby, they put her on a regimen of drugs that included an anti-nausea medication licensed in Britain and Canada but banned in the United States. Within a month, according to the journal of Transgender Health, the woman was producing droplets of milk. With three months – two weeks before the baby’s due date – she had increased her production to eight ounces of milk a day. In the end, the study showed, “she was able to achieve sufficient breast milk volume to be the sole source of nourishment for her child for six weeks,” according to the journal. Tamar Reisman, MD, assistant professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai and Zil Goldstein, MSN, program director of The Center of Transgender Medicine and Surgery at the Mount Sinai Health System, said that the case illustrates that, in some circumstances, modest but functional lactation can be induced in transgender women who did not give birth or undergo surgery. “We believe that this is the first formal report in the medical literature of induced lactation in a transgender woman,” said the study’s authors, Dr. Reisman and Ms. Goldstein. - Tamar Reisman, MD, Assistant Professor, Medicine, Endocrinology, Diabetes, and Bone Disease, Icahn School of Medicine at Mount Sinai - Zil Goldstein, MSN, Assistant Professor, Medical Education, Icahn School of Medicine at Mount Sinai, Program Director, The Center for Transgender Medicine and Surgery, The Mount Sinai Health System Learn more: https://www.nytimes.com/2018/02/15/health/transgender-woman-breast-feed.html Additional coverage: Medical Xpress https://medicalxpress.com/news/2018-02-transgender-women-breastfeed-case.html BBC Radio http://www.bbc.co.uk/programmes/w172vrbbglfzrkj WGNO ABC News http://wgno.com/2018/02/15/transgender-woman-breastfeeds-infant-in-first- documented-case/ The Japan Times https://www.japantimes.co.jp/news/2018/02/16/world/science-health- world/transgender-women-can-breast-feed-first-case-study-shows/#.WobwpNKPJQI Fox News http://fox17online.com/2018/02/16/transgender-woman-breastfeeds-infant-in-first- documented-case/ IFL Science http://www.iflscience.com/health-and-medicine/transgender-woman-breastfeeds-her- newborn-baby-in-first-documented-case/ Live Science https://www.livescience.com/61782-transgender-woman-breast-feeding.html Vice https://tonic.vice.com/en_us/article/zmwzn5/transgender-woman-breastfeeding HealthDay https://consumer.healthday.com/health-technology-information-18/press-medical-and-health- reporting-news-552/health-highlights-feb-15-2018-731163.html U.S. News & World Report https://health.usnews.com/health-care/articles/2018-02-15/health-highlights- feb-15-2018 The Health Site http://www.thehealthsite.com/news/transgender-woman-successfully-breastfeeds-baby- in-world-first-ag0218/ WebMD https://www.webmd.com/baby/news/20180216/transgender-woman-able-to-breast-feed-infant? src=RSS_PUBLIC NewNowNext http://www.newnownext.com/transgender-woman-breastfeds-baby-first-time- ever/02/2018/ American Nurse Today https://www.americannursetoday.com/nurse-practitioner-co-authors-case-study- breastfeeding-transgender-woman/ EndrTimes http://endrtimes.blogspot.com/2018/02/breast-feeds-baby-after-hospital.html International Business Times http://www.ibtimes.com/trans-woman-breastfeeds-through-first-ever- induced-lactation-case-2654073 People http://people.com/bodies/transgender-woman-first-breastfeed-her-baby/ Mothering http://www.mothering.com/articles/transgender-woman-becomes-worlds-first-to-exclusively- breastfeed/

Insight News – February 2 Military Tech Identifies Eclipse-Shaped Eye Damage A woman who viewed the solar eclipse earlier this year without protective glasses has been left with permanent crescent-shaped damage over one of her retinas that match exactly the shape of the sun at the time of the eclipse. The case, published in JAMA Ophthalmology, was the first of its kind to be assessed with modern imaging tools due to the relative rarity of solar eclipses. Study co-author, Chris Wu, MD, resident physician at the New York Eye and Ear Infirmary of Mount Sinai said it was exciting to see the correlation between the symptoms and the photoreceptor injury on a cellular level. “This study can prepare doctors and patients for the next eclipse in 2024 and make them more informed of the risks of directly viewing the sun without protective eyewear,” he added. “New York Eye and Ear Infirmary is one of the few sites in North America with access to this technology, and using this to get an exact look at this retinal damage on such a precise level will help clinicians better understand the condition,” said lead investigator, Avnish Deobhakta, MD, an ophthalmologist at the New York Eye and Ear Infirmary of Mount Sinai. - Chris Wu, MD, Resident Physician, New York Eye and Ear Infirmary of Mount Sinai - Avnish Deobhakta, MD, Assistant Professor, Vitreoretinal Surgery, Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, Icahn School of Medicine at Mount Sinai Learn more: http://www.insightnews.com.au/Article3/1412/Military-tech-identifies-eclipse-shaped-eye- damage

Gadgets Now – February 16 AI Has Touched A Remarkable High In Past Two Years — Shilpa Phadnis AI is the development of computer systems able to perform tasks normally requiring human intelligence, such as visual perception, speech recognition, decision-making, and translation between languages. The phenomenal increases in computing power in recent times at extremely affordable costs, combined with powerful new algorithms, have democratized AI significantly. The AI System at the Mount Sinai Health System, called Deep Patient, has analyzed electronic health records from 700,000 patients. Deep Patient has taught itself to predict risk factors for 78 different diseases – and doctors now turn to the system to aid in diagnoses. - Mount Sinai Health System Learn more: https://www.gadgetsnow.com/tech-news/in-business-lexicon-ai-has-touched-a-remarkable- high-in-past-2-years/articleshow/62941725.cms

MedPage Today – February 15 Brave New World In Neurorehabilitation Advancements— Kristen Monaco The field of neurorehabilitation is burgeoning, explained David Putrino, PhD, assistant professor of rehabilitation medicine at the Icahn School of Medicine at Mount Sinai and director of rehabilitation innovation at the Mount Sinai Health System. He breaks down – from active-engagement to neuromodulation and robotics – everything providers should know when working with patients recovering from neurological damage, and research gaps that still need filling. ” There's a brave new world of wearables, of motion-capture devices, of force platforms, of things that don't actually cost all that much money, but can quantify someone's function in a very precise way and actually let us know if we're having an influence on whether or not they're getting better and what their level of function is, and maybe even what level of function they can expect down the track,” said Dr. Putrino. - David Putrino, PhD, Assistant Professor, Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, Director, Rehabilitation Innovation, Mount Sinai Health System Learn more: https://www.medpagetoday.com/neurology/generalneurology/71178

The New York Times – February 15 In Allergy Bullying, Food Can Hurt — Roni Caryn Rabin Many parents of children with food allergies have been disturbed by a scene in the new Peter Rabbit film, in which rabbits hurl a blackberry at a human character with severe food allergies, causing him to go into anaphylactic shock. Sony Pictures has issued an apology, but parents say the movie illustrates one of the persistent preventable threats to their children’s health: bullies who pick on children because of their food allergies, going beyond verbal taunting to attack them with allergens. Among children who were bullied, one study found, more than half said they had been touched by an allergen, had an allergen thrown or waved at them or had their food intentionally contaminated with an allergen. “Most of the bullying was verbal, as in ‘Ha ha, you can’t eat this,’ but occasionally they would wave the food at the person and threaten them with it, and if they dropped the allergen into the child’s own food, that could cause a serious reaction,” said the author of that study, Scott Sicherer, MD, professor of pediatrics, allergy and immunology, and chief of the division of allergy and immunology at the Jaffe Food Allergy Institute at the Icahn School of Medicine at Mount Sinai. - Scott Sicherer, MD, Professor, Pediatrics, Allergy and Immunology, Chief, Division of Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.nytimes.com/2018/02/15/well/family/in-allergy-bullying-food-can-hurt.html

Healio – February 15 As Obesity-Related Health Costs Rise, Experts Warn Of Far-Reaching Complications — Regina Schaffer Obesity-related health care costs in the United States rose 29 percent between 2001 and 2015, and new data from the most populous states reveal that the cost burden varies throughout the country, according to research published in Clinical Chemistry. Reshmi Srinath, MD, assistant professor of medicine, endocrinology, diabetes and bone disease and director of the weight and metabolism management program at the Icahn School of Medicine at Mount Sinai, said obesity puts a patient at risk for multiple conditions, ultimately increasing the health care cost burden. “Our biggest concern as endocrinologists is the risk for heart disease and risk for stroke. There’s a greater risk for cancer, and then, endocrine-wise, we see obesity is directly tied to fertility. Men present with low testosterone, and women present with conditions such as polycystic ovary syndrome, which is associated with infertility. We see the risk for sleep issues and sleep apnea, which is also tied in with metabolic complications.” - Reshmi Srinath, MD, Assistant Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Director, Weight and Metabolism Management Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/endocrinology/obesity/news/in-the-journals/%7Bba41f239-2825- 4953-89bc-444a18997dd3%7D/as-obesity-related-health-costs-rise-experts-warn-of-far-reaching- complications

Everyday Health – February 15 What Is Hyperglycemia? How To Prevent, Detect, And Treat High Blood Sugar — Kristeen Cherney Typically, your doctor will diagnose you with insulin resistance, prediabetes, or diabetes after seeing your blood sugar levels are abnormal. Often, the test they’ll use is the hemoglobin A1C, or A1C test for short, said Gregory Dodell, MD, assistant clinical professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai. A1C is a two- to three-month average of your blood sugar levels, said Dr. Dodell, explaining that the test measures the percentage of sugar that’s attached to your red blood cells. Dr. Dodell also said your doctor may also test your blood sugar levels through fasting glucose test. - Gregory Dodell, MD, Assistant Clinical Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai Learn more: https://www.everydayhealth.com/type-2-diabetes/guide/hyperglycemia/

The Guardian – February 16 Stress In Fathers May Alter Sperm And Affect Behavior In Offspring — Nicola Davis Stressed fathers may end up with changes to their sperm that could affect behavior in their offspring, research in mice has shown. While the team is currently examining whether similar effects occur in humans, researchers say pilot studies have shown that changes in vesicles in men’s semen mirror that in their sperm, suggesting that, as in mice, the two interact. are also thought to play a role in psychiatric conditions, with new research presented by Paul J. Kenny, PhD, professor and chair of neuroscience at the drug discovery institute at the Icahn School of Medicine at Mount Sinai, suggesting that changes in levels of particular microRNA molecules could be linked to anxious or fearful behavior. - Paul J. Kenny, PhD, Professor, Chair, Neuroscience, Director, Drug Discovery Institute, Icahn School of Medicine at Mount Sinai Learn more: https://www.theguardian.com/science/2018/feb/16/stress-fathers-behaviour-offspring- altering-sperm-micrornas

Long Island Herald – February 15 Bellmore-Merrick Central District Teacher Shares His ‘Incredible Gift’ — Alexandra Ramey Ken Abbott emphasizes the importance of being an organ donor. New York state has among the country’s lowest donation consent rates, according to the American Journal of Transplantation, he said, and he finds that statistic distressing. Abott was given a heart transplant back in 2016, at Mount Sinai Hospital, after waiting six months for a donor. The earth science teacher had lived for five years with an internal pacemaker implant, after being diagnosed with an autoimmune condition that attacked his heart. Abott keeps a pillow given to him by Mount Sinai Hospital staff on a glass shelf in the back of his classroom so he can remember the gift of his new heart. - The Mount Sinai Hospital Learn more: http://www.liherald.com/stories/central-district-teacher-shares-his-incredible-gift,100171

MedPage Today – February 15 Mass Shootings Trigger Change For Emergency Medicine — Nicole Lou In the aftermath of Wednesday's mass shooting at a Florida high school, the emergency medicine community is once again thinking about how to improve disaster preparedness as it waits for more details to be made available on how peers responded to the tragedy that left 17 dead. That's not to say that medical professionals failed in Broward County: a semiautomatic AR-15 assault rifle causes "a crazy amount of damage in a human body," said Michael Redlener, MD, medical director of prehospital care and disaster preparedness at Mount Sinai St. Luke’s. Still, in the past decade, the emergency medicine community has been working to overhaul responses in order to keep up with the tide of mass shootings. Moreover, a new appreciation of how unique deadly bleeding can be – realized just within the last seven years, according to Dr. Redlener – is making bleeding a main priority for EMS and changing how civilian responders are encouraged to help in an emergency. Dr. Redlener said that coordination before victims arrive at the hospital among EMS, police, bystanders, and hospital operations is key. Thanks to modern tools, communication can be enhanced and people triaged and taken to the operating room or ICU more quickly. - Michael Redlener, MD, Assistant Professor, Emergency Medicine, Icahn School of Medicine at Mount Sinai, Medical Director, Prehospital Care and Disaster Preparedness, Mount Sinai St. Luke’s Learn more: https://www.medpagetoday.com/emergencymedicine/emergencymedicine/71195

PHYS.org – February 16 In Mice, A Single Vaccine Prompts The Immune System To Fight Breast, Lung, And Skin Cancers — Melissa Healy In research that could open a new frontier in the young field of cancer immunotherapy, Stanford University scientists have found that inoculating mice with stem cells that have been inactivated by radiation significantly boosted the animals' defenses against cancers of the breast, lungs and skin. And when administered alongside an immune booster already in use among humans, a vaccine of inactivated stem cells prevented cancer from recurring and spreading in mice that already had tumors surgically removed. Eirini Papapetrou, MD, PhD, associate professor of oncological sciences, medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai, called the study’s results “very remarkable.” A study in mice is a far cry from demonstrating that such a vaccine would protect humans from cancer, said Dr. Papapetrou, who was not involved in the new research. And as researchers aim to translate their findings to human treatments, they will have to show that inactivated stem cells are safe, she added. - Eirini Papapetrou, MD, PhD, Associate Professor, Oncological Sciences, Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://phys.org/news/2018-02-mice-vaccine-prompts-immune-breast.html

NBC San Diego – February 15 San Diego Company’s First Blood Test To Evaluate Receives Green Light — Jared Whitlock A first-ever test from San Diego’s Banyan Biomarkers to help doctors diagnose traumatic brain injuries has won Federal Drug Administration approval. The privately held company anticipates the test will reduce the number of CT scans ordered on patients for a possible concussion, lowering costs and radiation exposure. More than 90 percent of patients posting up at the emergency department with mild concussion symptoms receive a negative CT scan. “Brain biomarkers will change the practice of emergency care for mild TBI (traumatic brain injury) and will greatly assist a large number of patients. The impact will be improved medical care by reducing radiation exposure to the patient and improving efficiency in the emergency department,” said Andy S. Jagoda, MD, professor and chair of emergency medicine at the Icahn School of Medicine at Mount Sinai. - Andy S. Jagoda, MD, Professor, Chair, Emergency Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.nbcsandiego.com/news/local/San-Diego-Banyan-Biomarkers-First-Blood-Test- to-Evaluate--474189083.html

Self Magazine – February 15 Selma Blair Spent Her Valentine’s Day Getting Steroid Injection In Her Sinuses — Korin Miller Getting a steroid injection in your sinuses sounds terrible, but it’s a tool doctors use to treat sinus pain when other methods fail. People who have to get corticosteroid injections usually suffer from severe or chronic sinusitis, a condition that causes your nasal passages to become inflamed and swollen for at least 12 weeks despite other treatments. You may end up having the shot in your sinuses if you suffer from nasal polyps (painless, noncancerous growths on the lining of your nasal passages or sinuses), or enlarged turbinates, which are ridges of tissue that are in your nose, said Anthony Del Signore, MD, director of rhinology and endoscopic skull base surgery at Mount Sinai Union Square. Before that, though, your doctor will numb your nasal passages to help dull or slow the transmission of the nerves in your sinuses, making it less likely that you’ll be in pain when you actually get the shot, said Dr. Del Signore. - Anthony Del Signore, MD, Assistant Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai, Director, Rhinology and Endoscopic Skull Base Surgery, Mount Sinai Union Square Learn more: https://www.self.com/story/selma-blair-steroid-injection-in-her-sinuses

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - February 20, 2018 Date: Tuesday, February 20, 2018 2:01:20 PM Attachments: ATT00001.txt

In the News February 20, 2018

MedPage Today – February 19 Strong Eczema Response To JAK Inhibitor— Charles Bankhead Patients with moderate or severe atopic dermatitis (AD) had as much as 74 percent improvement in disease status with the oral Janus kinase (JAK) inhibitor upadacitinib, a randomized trial showed. Across the range of doses tested, upadacitinib had a favorable safety profile, reported lead investigator Emma Guttman-Yassky, PhD, professor of dermatology and clinical immunology, vice chair of research in the department of dermatology and the director of the Center for Excellence in Eczema at the Icahn School of Medicine at Mount Sinai, at the American Academy of Dermatology meeting. "The emerging positive benefit/risk profile observed for upadacitinib in atopic dermatitis supports proceeding with phase III trials," Dr. Guttman-Yassky concluded. Upadacitinib is a once-daily, oral JAK1-selective inhibitor under evaluation for several inflammatory diseases and the FDA recently granted breakthrough therapy status for the drug. - Emma Guttman-Yassky, MD, PhD, The Sol & Clara Professor, Dermatology, Clinical Immunology, Medicine, Vice Chair, Research, Department of Dermatology, Director, The Center for Excellence in Eczema, Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/meetingcoverage/aad/71244 Additional coverage: AAD Meeting News https://aadmeetingnews.org/2018-annual-meeting-dailies/jak-inhibitors-show-promise-for-ad/ Dermatology Times http://dermatologytimes.modernmedicine.com/dermatology-times/news/aad-meeting-preview-atopic-dermatitis-treatments Street Insider https://www.streetinsider.com/FDA/AbbVie+%28ABBV%29+Announced+New+Positive+Results+from+Phase+2b+Data+on+Upadacitinib+in+Atopic+Dermatitis/13835793.html

MedPage Today – February 18 Using Biology Of Atopic Dermatitis To Improve Therapy — Charles Bankhead Following the therapeutic model of psoriasis, treatment for atopic dermatitis (AD) increasingly focuses on identifying and targeting specific molecules involved in etiology and pathogenesis. The potential for applying the psoriasis model to AD did not become apparent until recently, as AD is a more complex condition, involving abnormalities in both immune response and the skin barrier, said Emma Guttman-Yassky, PhD, professor of dermatology and clinical immunology, vice chair of research in the department of dermatology and the director of the Center for Excellence in Eczema at the Icahn School of Medicine at Mount Sinai, at the American Academy of Dermatology meeting. "Unlike psoriasis, AD cannot be explained by a single cytokine pathway," said Dr. Guttman-Yassky. "But the consistent cytokine axis activated across all phenotypes appears to be Th2. Thus far, dupilumab shows similar in intrinsic/extrinsic and filaggrin-positive and negative AD phenotypes." - Emma Guttman-Yassky, MD, PhD, The Sol & Clara Professor, Dermatology, Clinical Immunology, Medicine, Vice Chair, Research, Department of Dermatology, Director, The Center for Excellence in Eczema, Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/meetingcoverage/aad/71229

Medscape – February 20 First Documented Case Of Transgender Woman Breastfeeding — Becky McCall A transgender woman has breastfed her partner's baby after stimulating milk production with a regimen of domperidone, estradiol, progesterone, and breast pumping, providing the sole source of nourishment for the baby's first six weeks. This is believed to be the first formal report of induced lactation in a transgender woman, lending weight to the argument that in some circumstances, modest but functional lactation can be induced in men who have transitioned to become women, say the authors, led by Tamar Reisman, MD, assistant professor of medicine, endocrinology, diabetes, and bone disease at the Icahn School of Medicine at Mount Sinai. - Tamar Reisman, MD, Assistant Professor, Medicine, Endocrinology, Diabetes, and Bone Disease, Icahn School of Medicine at Mount Sinai - Zil Goldstein, MSN, Assistant Professor, Medical Education, Icahn School of Medicine at Mount Sinai, Program Director, The Center for Transgender Medicine and Surgery, The Mount Sinai Health System Learn more: https://www.medscape.com/viewarticle/892858 Additional coverage: Cosmopolitan https://www.cosmopolitan.com/sex-love/a18208944/transgender-woman-breastfeeds-baby/ Pakistan Today https://www.pakistantoday.com.pk/2018/02/17/first-transgender-woman-breastfeeds-baby-for-six-weeks/

The New York Times – February 19 Finding Resilience, 25 Years After 1993 World Trade Center Bombing— Sharon Otterman For five and a half hours on February 26, 1993, Carl Selinger was trapped alone in an elevator at the World Trade Center, wondering if the smoke seeping in from the elevator shaft would kill him. Unaware it was a terror attack that had left him stranded; he spent the first hour writing a goodbye letter to his family on a piece of loose-leaf paper. The event last week at the 9/11 Memorial and Museum is one of several this month dedicated to the 25th anniversary of the bombing, focused on the long-term effects of trauma, and featured psychiatrists and survivors of the 1993 attack. Rachel Yehuda, PhD, professor of psychiatry and neuroscience and director of the division of traumatic stress studies at the Icahn School of Medicine at Mount Sinai, speaking at a panel, said each person handles trauma differently. “On the one hand, you have people who will be quite resilient, and who will reflect on what could have happened but didn’t, and try to get a life lesson or object lesson going, and try to use the event somehow in a positive way,” Dr. Yehuda said. “At the other extreme are people who remain very frightened, very overwhelmed.” And of course, there is a range of reactions in the middle, she said. - Rachel Yehuda, PhD, Professor, Psychiatry, Neuroscience, Director, Division of Traumatic Stress Studies, Icahn School of Medicine at Mount Sinai Learn more: https://www.nytimes.com/2018/02/19/nyregion/first-terror-attack-world-trade-center-anniversary.html

Trib Live – February 16 Phipps’ Symposium Tackles ‘Chemicals Of Concern’ — Mary Pickels Phipps Conservatory and Botanical Gardens is again planning a symposium to explore global and local environmental issues and their effects on human, animal and environmental health. The 2018 One Health One Planet, scheduled from 8:30 am to 5 pm on March 8, will focus on "Health Impacts: Chemicals of Concern in the Environment." Emphasis will focus on endocrine disruptors, with expert speakers, breakout sessions and networking planned. Featured speakers include Shanna Swan, PhD, professor of environmental medicine and public health, obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai. - Shanna Swan, PhD, Professor, Environmental Medicine and Public Health, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: http://triblive.com/aande/museums/13309309-74/phipps-symposium-tackles-chemicals-of-concern

Friedreich’s Ataxia News – February 20 Patient Advocacy Groups Worldwide Plan Events To Mark Rare Disease Day: February 28 — Larry Luxner From Athens to Atlanta, from San Diego to Sydney, people across the globe will mark World Rare Disease Day on February 28 in a variety of fun, creative ways. The goal: to raise awareness about the 7,000 or so known rare diseases, 95 percent of which have few treatments and no cures. The New York Genome Center will mark the day with an evening conference, “Rare Disease Genetics: Unlocking Insights for All.” Speakers include Max Gomez, medical correspondent for CBS News and Bruce Gelb, MD, professor of pediatrics, genetics and genomic sciences, and director of the Mindich Child and Health Development Institute at the Icahn School of Medicine at Mount Sinai. - Bruce Gelb, MD, Professor, Pediatrics, Cardiology, Genetics and Genomic Sciences, Director, Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai Learn more: https://friedreichsataxianews.com/2018/02/20/patient-advocacy-groups-worldwide-plan-events-mark-rare-disease-day-feb-28/

MedPage Today – February 17 Are ‘Vaccine Skeptics’ Responsible For Flu Deaths? — Molly Walker For months, speculation swirled around this year's flu season, and the apparent lack of efficacy of the vaccine in Australia earlier in the year, but did all that skepticism contribute to flu deaths in the U.S.? The CDC's most recent flu data indicates that an additional 22 children died from influenza-related causes and the portion of pneumonia and influenza-associated mortality hovers near 10 percent, far above the epidemic threshold for this particular week. Recently released flu vaccine efficacy data indicated that only a little over a quarter of pediatric deaths were in vaccinated children. Peter Palese, PhD, professor of chair of microbiology at the Icahn School of Medicine at Mount Sinai, was unequivocal in his response: “I fully agree with the statement that the antivaxxers are responsible for the needless deaths of many unvaccinated people.” - Peter Palese, PhD, Professor, Chair, Microbiology, Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/infectiousdisease/uritheflu/71225

The Wall Street Journal – February 17 In Hospitals, Pneumonia Is A Lethal Enemy — Lucette Lagnado At a time when the public is concerned with drug-resistant superbugs, researchers have identified another danger of going to the hospital: contracting pneumonia. Hospital- acquired pneumonia is more pervasive and urgent than most people realize. To battle germs and superbugs, hospitals are cleaning rooms and equipment thoroughly, controlling the use of antibiotics and dispensing hand sanitizer to patients, visitors and staff. Brian Koll, MD, professor of medicine and infectious diseases at the Icahn School of Medicine at Mount Sinai and executive medical director of infection prevention and control for the Mount Sinai Health System said oral-care initiatives make perfect sense, just like efforts to get patients to wash their hands. “You want to reduce the amount of bacteria in your mouth,” added Dr. Koll. Still, he believes more data are needed to come up with “evidence-based guidelines.” - Brian Koll, MD, Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai, Executive Medical Director, Infection Prevention and Control, Mount Sinai Health System Learn more: http://www.pharmacist.com/article/hospitals-pneumonia-lethal-enemy

Healio – February 16 Strong Evidence Lacking For Interventions For Below-The-Knee Lesions — Erik Swain Although some technologies have shown promise, the best interventions for treatment of below-the-knee lesions in patients with critical limb ischemia are yet to be determined, a speaker said at the International Symposium on Endovascular Therapy. “Below-the-knee trials in the U.S. have been few and far between,” said Robert Lookstein, MD, professor of radiology and surgery at the Icahn School of Medicine at Mount Sinai and vice chairman of the department of radiology at the Mount Sinai Health System. Drug-coated balloons have been very successful in above-the-knee lesions; however, “unfortunately, to date, there has never been a demonstrated benefit in terms of freedom from target lesion revascularization or freedom from amputation for these drug-coated balloons in the below-the-knee circulation,” he said, noting that the Lutonix BTK trial just completed enrollment and may provide better data in this area. - Robert Lookstein, MD, Professor, Radiology, Surgery, Icahn School of Medicine at Mount Sinai, Vice Chairman, Department of Radiology, Mount Sinai Health System Learn more: https://www.healio.com/cardiac-vascular-intervention/limb-salvage/news/online/%7B08361df5-40f7-403f-874b-3fca79901a75%7D/strong-evidence-lacking-for- interventions-for-below-the-knee-lesions

She Knows – February 20 Signs Of Ovarian Cancer You Might Miss — Elizabeth Yuko Ovarian cancer is the fifth-leading cause of death in women ages 35 to 74. The tricky part is that the symptoms of ovarian cancer can be easy to dismiss according to Stephanie V. Blank, MD, professor of gynecologic oncology, obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai and director of women’s health at Mount Sinai Chelsea Center. Some of these include bloating, bowel changes, abnormal urination and pelvic discomfort, she said. "Because there is not one hallmark symptom, you need a high index of suspicion to make the diagnosis," Dr. Blank explains. "Ovarian cancer is not necessarily at the top of the list of considerations, so oftentimes; patients will have had tests for many other conditions before the diagnosis is made." Women with genetic predisposition to ovarian cancer are most at risk, she added, including women with genetic mutations in some of the genes we know to be associated with ovarian cancer — BRCA1 and BRCA2 as well as several others. - Stephanie V. Blank, MD, Professor in the Division of Gynecologic Oncology, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Director of Women's Health, Mount Sinai Chelsea Center Learn more: http://www.sheknows.com/health-and-wellness/articles/1138288/signs-of-ovarian-cancer Additional coverage: Yahoo News https://www.yahoo.com/lifestyle/m/2df7fa8d-947e-3c9d-b309-e2aa370399a0/ovarian-cancer-is-hard-to.html

Self Magazine – February 19 Are Nasal Decongestants Actually ‘Addictive’? — Korin Miller Nasal decongestants are high on the list of seemingly innocent things people swear are actually “addictive.” While it’s easy to dismiss the concept of reliance on nasal decongestants as a health urban legend, doctors say it can actually happen. That doesn’t mean you shouldn’t use nasal decongestant sprays at all. “I tell my patients that it’s OK to use a nasal decongestant spray for one, two, or three days,” Anthony Del Signore, MD, assistant professor of otolaryngology at the Icahn School of Medicine at Mount Sinai and director of rhinology and endoscopic skull base surgery at Mount Sinai Union Square. After that, he said, you’re more likely to become dependent on them. - Anthony Del Signore, MD, Assistant Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai, Director, Rhinology and Endoscopic Skull Base Surgery, Mount Sinai Union Square Learn more: https://www.self.com/story/nasal-decongestant-spray-addictive

Forbes – February 15 Why DASH and Mediterranean Are The Best Diets For 2018 — Eustacia Huen In January, U.S. News & World Report released its annual ranking of the Best Diets Overall, which saw DASH and Mediterranean coming out on top. Touted for their balanced and realistic approach, there’s much more to these healthy eating plans that make them the best for 2018. Sara Wilson, MS, RD, CDN, senior director of clinical nutrition for the Mount Sinai Health System said that ultimately, as obvious as it may seem, “The success of any ‘diet’ lies in whether or not you can follow it.” With an uptrend in health and wellness in 2018, finding a healthy eating pattern that you can maintain is crucial. - Sara Wilson, MS, RD, CDN. Senior Director, Clinical Nutrition, Mount Sinai Health System Learn more: https://www.forbes.com/sites/eustaciahuen/2018/02/15/diet/#559b129361c9

Forbes – February 15 How This Melt-Resistant Ice Cream Sundae Can Even Be Lit On Fire — Eustacia Huen Made in cooperation by Kanazawa Ice with the Faculty of Pharmaceutical Sciences of Kanazawa University, these treats—a soft serve ice cream and an ice cream parfait— are so melt-resistant that they can even be lit on fire. These new items contain the patented strawberry polyphenol which has a property that keeps the soft serve from melting at room temperature for 30 minutes; or 104 degrees Fahrenheit for three hours in popsicle-form. Sara Wilson, MS, RD, CDN, senior director of clinical nutrition at the Mount Sinai Health System said, “Polyphenols are phytochemicals that occur naturally in plants. Known for their antioxidant properties, studies have reported a diet rich in polyphenols may offer protection against inflammation and chronic diseases. However, there is still so much we don’t know and understand about polyphenols, including absorption, metabolism, and how much is too much.” So while Wilson certainly will not add this product to her list of healthy recommendations, polyphenol as an ingredient isn’t necessarily bad for you. However, like most things, she added, “You still have to consider the source. When it comes to ice cream, with or without polyphenols, moderation is key.” - Sara Wilson, MS, RD, CDN. Senior Director, Clinical Nutrition, Mount Sinai Health System Learn more: https://www.forbes.com/sites/eustaciahuen/2018/01/31/sundae/#720bb09a6a27

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - February 21, 2018 Date: Wednesday, February 21, 2018 12:27:37 PM Attachments: ATT00001.txt

In the News February 21, 2018

CBS New York – February 20 Rare Tumor Could Help Produce Insulin For Type 1 Diabetes, Study Shows — Dr. Max Gomez Researchers have found a surprising potential ally in the search for a cure for Type-1 diabetes. It’s a rare tumor that produces a lot of what diabetics are missing – insulin. Type-1 diabetics own immune system is destroying beta cells that make insulin. To cure diabetes you have to stop that auto-immune attack, and then you have to replace the destroyed beta cells. That’s where the tumor comes in. Alecia Wesner was diagnosed with Type-1 diabetes at age six, a continuous glucose monitor and a small insulin pump made managing her blood sugar easier, but not easy. “There’s no break from Type-1 diabetes,” said Alicia. What gives Alecia a lot of hope for the future is what’s being done in the lab of Andrew Stewart, MD, director of the diabetes, obesity and metabolism institute at the Icahn School of Medicine at Mount Sinai. He explained that even though Alicia has had diabetes for almost four decades, she still has a few beta cells left. The key to getting them to replicate enough to replace the destroyed beta cells may lie in the DNA of rare benign tumors called beta cell insulinomas. “Those small insulinoma tumors in the pancreas have the genomic recipe for knowing how to make beta cells replicate,” Dr. Stewart said. - Andrew Stewart, MD, Director of the Diabetes, Obesity, and Metabolism Institute at the Icahn School of Medicine at Mount Sinai Learn more: http://newyork.cbslocal.com/2018/02/20/insulin-tumor-for-diabetes/

IBD News Today – February 20 FDA Oks Clinical Trial To Test Bacteriophage-Based Treatment For Crohn’s — Carolina Henriques The FDA recently cleared a Phase 1/2a clinical trial to study a set of bacteriophages to treat inflammatory bowel disease, specifically Crohn’s disease. Researchers developed a new therapy based on bacteriophages that specifically targets the various Escherichia coli bacteria strains that have been found in patients with Crohn’s disease. The clinical trial, which will be conducted at Mount Sinai Hospital, will test the feasibility and effectiveness of the therapy in human patients. Jean-Frederic Colombel, MD, professor of medicine and gastroenterology at the Icahn School of Medicine at Mount Sinai and director of the Susan and Leonard Feinstein IBD clinical center at Mount Sinai, the principal investigator of this clinical trial said, “Escherichia coli have been implicated in the pathogenesis development of Crohn’s disease. Bacteriophages may offer a much-needed approach for specifically targeting AIEC in the human gastrointestinal tract, reducing the risk of progression of Crohn’s disease. If the approach shows efficacy in the planned clinical trials in our hospital, it will enhance and expedite product development and could ultimately benefit hundreds of thousands of people suffering from Crohn’s disease.” - Jean-Frédéric Colombel, MD, Professor, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai, Director, Susan and Leonard Feinstein IBD Clinical Center at Mount Sinai Learn more: https://ibdnewstoday.com/2018/02/20/fda-approves-clinical-trial-testing-bacteriophages- crohns-disease/

MedPage Today – February 21 Long-Term Efficacy Of Brodalumab For The Treatment Of Moderate To Severe Psoriasis — Mark G. Lebwohl, MD Mark Lebwohl, MD, professor and chair of dermatology at the Icahn School of Medicine at Mount Sinai and system chair of the Waldman department of dermatology for the Mount Sinai Health System, speaks about the long term efficacy of brodalumab for the treatment of moderate to severe psoriasis. “There are several key findings from the study. First of all - the drug is very fast, second of all - it is very effective, and third of all - the effect persists for up to 108 weeks in this study,” Dr. Lebwohl said. - Mark Lebwohl, MD, Professor, Chair, Dermatology, Icahn School of Medicine at Mount Sinai, System Chair, Waldman Department of Dermatology, Mount Sinai Health System Learn more: https://www.medpagetoday.com/video/meetingcoverage/aad/aad-video-conference- reporter-2018/165

MedPage Today – February 20 Low-Fat Versus Low-Carb: Both Work For Weight Loss — Kristen Monaco In a face-off between a low-fat and a low-carbohydrate diet, neither reigned supreme. The results, published in JAMA, showed no significant interaction between the amount of weight loss, individual genotype responsiveness patterns, and appropriate matching to corresponding diet type. Reshmi Srinath, MD, assistant professor of medicine, endocrinology, diabetes and bone disease and director of the weight and metabolism program at the Icahn School of Medicine at Mount Sinai, who was not involved in the study said, “The weight loss results are comparable to prior studies where we see weight loss really is dependent on compliance rather than the diet itself. But I was hoping to see some significant difference in the weight lost by those matched by genotype.” She added that this study furthers the need to investigate the role of genetics on weight loss and being able to tailor a diet to a particular individual based on their genetics. - Reshmi Srinath, MD, Assistant Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Director, Weight and Metabolism Management Program, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/primarycare/dietnutrition/71267

Healthline – February 21 New Blood Test Can’t Really Detect Concussions — Kristen Fischer The FDA recently fast-tracked approval for a blood test that’s said to help detect concussions, but experts say the test’s capabilities are being overstated. In short, it can’t detect concussions. And it’s only meant for adults. CT scan technology does more than give a “yes” or “no” when it comes to detecting concussions, noted David Putrino, PhD, assistant professor of rehabilitation medicine at the Icahn School of Medicine at Mount Sinai and director of rehabilitation innovation for the Mount Sinai Health System. “They allow physicians to visualize the brain and evaluate the extent of brain injury, which you simply cannot do with a blood test.” Dr. Putrino added that the blood test is most effective within 12 hours of an injury. Many people don’t seek medical advice during that time frame – another limitation of solely using the blood test for detection. - David Putrino, PhD, Assistant Professor, Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, Director, Rehabilitation Innovation, Mount Sinai Health System Learn more: https://www.healthline.com/health-news/new-blood-test-cant-really-detect-concussions

Reader’s Digest – February 20 Nine Symptoms Of Ovulation You Might Be Missing — Krissy Howard Abdominal cramping is perhaps one of the most common symptoms of ovulation. The mild cramping usually happens in the lower abdominal area, typically on one side of the pelvis, on the same side from which you release an egg, according to Fahimeh Sasan, DO, assistant professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai. "This pain is called 'mittelschmerz,' a German word meaning 'middle' and 'pain'," Dr. Sasan said, and it occurs mid-month for many women. If you have severe cramps, along with painful periods, talk to your doctor to rule out uterine fibroids or endometriosis. Pay attention to these symptoms of uterine fibroids and these signs of endometriosis. - Fahimeh Sasan, DO, Assistant Professor, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.rd.com/health/conditions/ovulation-symptoms/

Daily Mail – February 20 Chrissy Teigen Explains Why Her Second Pregnancy Is So Different To Her First — Megan Sheets Model Chrissy Teigen has been revealing intimate details of her second pregnancy on social media. Teigen’s experiences highlight some of the typical differences between a woman’s first and second pregnancies. Nutritionally speaking, the biggest concern during a second pregnancy is iron deficiency, said Shari Brasner, MD, assistant clinical professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai. Pregnancy in general puts a big strain on the blood’s iron stores, and many women go into their first pregnancy iron deficient. During the second pregnancy a woman’s body may not have fully recovered from the first one, making the deficiency even worse. Iron deficiency can lead to low energy levels and headaches. Luckily, this problem is easy to remedy with the help of iron supplements or by paying extra attention to diet. - Shari Brasner, MD, Assistant Clinical Professor, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: http://www.dailymail.co.uk/health/article-5415189/Chrissy-Teigen-shares-second- pregnancy-experience.html

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - February 22, 2018 Date: Thursday, February 22, 2018 11:40:06 AM Attachments: ATT00001.txt

In the News February 22, 2018

Palm Beach Florida Weekly – February 22 Jupiter Medical Center: The Center Of Excellence In Cardiac Care Jupiter Medical Center – currently a Center of Excellence in cardiac care – has invested heavily in expanding its interventional cardiac capabilities over the past three years. Since 2015, the hospital has forged an innovative clinical partnership with Mount Sinai Heart and added two interventional cardiac catheterization labs for procedures such as balloon angioplasty and coronary stents, increasing by 300 percent the number of coronary interventions Jupiter Medical Center performs. “Our goal is to improve the high level of cardiac care we already offer at Jupiter Medical Center,” said Gonzalo J. Loveday, MD, assistant professor of medicine and cardiology at the Icahn School of Medicine at Mount Sinai and chief medical director of Mount Sinai Heart New York at Jupiter Medical Center. “It’s crucial to have top- quality cardiac care minutes from home when seconds really count.” Jupiter Medical Center’s affiliation with Mount Sinai New York encompasses all areas of cardiac care: wellness and preventive cardiology, noninvasive diagnostics, interventional cardiology, congestive heart failure, cardiac rehabilitation, electrophysiology, research and education, and the seamless continuity of care. - Gonzalo J. Loveday, MD, Assistant Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, Chief Medical Director, Mount Sinai Heart New York at Jupiter Medical Center, Medical Director, Mount Sinai Doctors Palm Beach Learn more: https://palmbeach.floridaweekly.com/articles/jupiter-medical-center-announces-6-million-in- gifts/

MedPage Today – February 21 AAD Conference: New Developments In Atopic Dermatitis — Emma Guttman-Yassky, MD Emma Guttman-Yassky, MD, PhD, the Sol & Clara professor of dermatology, clinical immunology and medicine, vice chair of research in the department of dermatology and director of the center for excellence in eczema in the laboratory of inflammatory skin diseases at the Icahn School of Medicine at Mount Sinai discusses new developments in atopic dermatitis. “I think there is a lot of excitement now in atopic dermatitis because we are following the same model of psoriasis. We have a growing knowledge of molecules that are evolved in the pathogenesis of the disease, and we are going after them with therapeutic targeting,” she said. - Emma Guttman-Yassky, MD, PhD, The Sol & Clara Professor, Dermatology, Clinical Immunology, Medicine, Vice Chair, Research, Department of Dermatology, Director, The Center for Excellence in Eczema, Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/video/meetingcoverage/aad/aad-video-conference- reporter-2018/165/2391 Additional coverage: Medscape https://www.medscape.com/viewarticle/892961

Dermatology Times – February 21 From New Vaccines To The Advent Of New Neurotoxins — Lisette Hilton It’s an extraordinary time in dermatology, said Mark Lebwohl, MD, professor and chair of dermatology at the Icahn School of Medicine at Mount Sinai and system chair of the Waldman department of dermatology for the Mount Sinai Health System. He added that today, there are treatments for conditions that didn’t have viable treatment option ten or 20 years ago. Dr. Lebwohl directed the “What’s New in Dermatology,” session on February 20th during the American Academy of Dermatology meeting in San Diego. For surgical dermatology, target treatments for advanced and metastatic non-melanoma skin cancers have been impactful, said Desiree Ratner, MD, director of the comprehensive skin cancer center at Mount Sinai Downtown Chelsea Center. “What's new in surgical dermatology these days relates to the management of advanced non-melanoma skin cancers, for which we really haven't had any options until quite recently,” said Dr. Ratner. - Mark Lebwohl, MD, Professor, Chair, Dermatology, Icahn School of Medicine at Mount Sinai, System Chair, Waldman Department of Dermatology, Mount Sinai Health System - Desiree Ratner, MD, Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, The Comprehensive Skin Cancer Center, Mount Sinai Downtown Learn more: http://dermatologytimes.modernmedicine.com/news/new-vaccines-advent-new-neurotoxins

Daily Mail – February 21 A Cure For Peanut Allergies? — Jaleesa Baulkman New research suggests daily doses of peanut powder could prevent the allergy. Scientists said 67 percent of children who consumed daily doses of peanut powder, contained in a capsule and sprinkled over food, were able to tolerate roughly two peanuts after a year. For years, researchers have tried to come up with a cure for peanut allergies, but the peanut powder capsule is the only treatment to come close to preventing them. The new study builds on previous research that suggests exposing children to peanuts earlier could prevent them from developing the allergy. In 2017, research published in the JAMA found a skin patch developed by the Icahn School of Medicine at Mount Sinai, left patients ten times more resilient to the peanut allergy. The device was designed to gradually expose patients to the proteins that give them an allergic reaction. - Icahn School of Medicine at Mount Sinai Learn more: http://www.dailymail.co.uk/health/article-5417787/Peanut-capsules-cure-children-peanut- allergies.html

Yahoo News – February 22 Half Of Women Are Missing This Telltale Sign Of Ovarian Cancer, Study Finds — Rachel Grumman Bender Women are more likely to blame their eating habits when they’re constantly bloated rather than get it checked out by their doctors, even though that’s a major sign of ovarian cancer, according to a new study. Ovarian cancer — which ranks fifth in cancer deaths among women, according to the American Cancer Society — is notoriously hard to detect early on for several reasons. “The signs and symptoms are non- specific and can be easily written off,” said Stephanie Blank, MD, professor of gynecologic oncology, obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai and director of women’s health for the Mount Sinai Health System. “Ovarian cancer does not usually cause noticeable symptoms until it has spread, and there is no effective screening test for ovarian cancer.” She added that the best way to determine if you are at an increased genetic risk of cancer is to know your family history and discuss it with your doctor. “If you are found to be at increased genetic risk of cancer, you can take measures to prevent cancer and save your own life,” said Dr. Blank. “That said, the majority of women who develop ovarian cancer will not have a family history of cancer. So not having cancer in the family does not mean you will not get ovarian cancer.” - Stephanie V. Blank, MD, Professor in the Division of Gynecologic Oncology, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, Director of Women's Health, Mount Sinai Chelsea Center Learn more: https://finance.yahoo.com/news/half-women-missing-telltale-sign-ovarian-cancer-study- finds-140055719.html

Uro Today – February 21 Addition Of Fluciclovine F-18 To NCCN Guidelines For PET Imaging For Suspected Recurrent Prostate Cancer Blue Earth Diagnostics, a molecular imaging diagnostics company, announced that Axumin (fluciclovine F 18) injection has been added to the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology for Prostate Cancer. These updated NCCN Guidelines state that F-18 fluciclovine PET/CT or PET/MRI should be considered in the clinical workup of patients with recurrence or progression of their prostate cancer. “Referring physicians need actionable information to guide patient management decisions,” said Lale Kostakoglu, MD, professor of radiology and chief of nuclear medicine and molecular imaging at the Icahn School of Medicine at Mount Sinai. “A PET imaging agent such as Axumin that can reliably detect and localize recurrent prostate cancer is important, due to the limited ability of other currently used imaging procedures to identify the extent and localization of recurrent disease in these patients.” - Lale Kostakoglu, MD, Professor, Radiology, Chief, Nuclear Medicine and Molecular Imagine, Icahn School of Medicine at Mount Sinai Learn more: https://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/102236- addition-of-fluciclovine-f18-to-nccn-guidelines-for-pet-imaging-for-suspected-recurrent-prostate- cancer.html

Good Morning America – February 22 Wendy Williams Reveals Health Struggle — Eva Pilgrim Talk show host, Wendy Williams announced that she’s taking time off to deal with Graves’ disease. Williams will step away to deal with hypothyroidism and Graves’ disease. “Graves’ disease is an autoimmune disorder that causes an over production of thyroid hormone. I have had patients with Graves’ disease who report fainting prior to being diagnosed,” said Barrie Weinstein, MD, assistant professor of medicine, endocrinology, diabetes and bone disease at the Icahn School of Medicine at Mount Sinai. Symptoms include fatigue, difficulty sleeping, irritability, weight loss, and bulging eyes. “Some patients come in having had symptoms for many months and are really feeling unwell and exhausted. Having them take a break from work is often a very smart idea to help them recover.” Dr. Weinstein added. - Barrie Weinstein, MD, Assistant Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai Learn more: http://abcnews.go.com/GMA/Culture/video/wendy-williams-announces-taking-time-health- reasons-53258416

The East Hampton Star – February 22 Family Copes With A Rare Disease — Judy D’Mello Imagine what it would be like to live without answers to your most basic questions. That is the harsh reality not only for many patients with rare diseases, but especially for their families. In 2016, five-year- old Rowland Egerton-Warburton was diagnosed with ADNP syndrome, also known as Helsmoortel- VanDerAa syndrome. This extremely rare neurodevelopmental disorder is caused by a mutation in the activity-dependent neuroprotective protein gene that regulates brain formation, development, and function. ADNP became official in the U.S. in 2014, when Sandra Sermone’s son, Tony, became the first person in the country to be diagnosed with it and only the 11th worldwide. Rowland is mostly nonverbal, but his lack of vocabulary is made up for by giggling and chirping his way through the day, despite the fact his days are filled by a tag team of specialists. Lisa Macaluso, a licensed applied-behavior analyst works with Rowland, who is known as “the autism whisperer” among parents of autistic children, and was recommended by Alexander Kolevzon, MD, clinical director of the Seaver Autism Center for research and treatment at the Icahn School of Medicine at Mount Sinai. - Alexander Kolevzon, MD, Professor, Psychiatry, Pediatrics, Clinical Director, Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, Learn more: http://easthamptonstar.com/Education/2018222/Family-Copes-Rare-Disease

Yahoo News – February 21 12-Year-Old Student Nicknamed ‘Trash Girl’ By Bullies Just Wants To Make The World A Better Place — Korin Miller Nadia Sparkes has been nicknamed ‘Trash Girl’ by bullies at her school because she picks up trash on the two-mile route from her school to her house. The 12 year old uses the basket of her bike to collect trash and, in the short time she’s been doing this, Sparkes has already collected more than two recycling bins worth of plastic. Unfortunately, the bullying isn’t surprising, said Jacob Ham, PhD, director of the center for child trauma and resilience at the Icahn School of Medicine at Mount Sinai; he added that there are two major types of bullying. “Bullying that’s done because the child has been hurt in the past and want to hurt other, and bullying because kids want to figure out who they are and where they belong.” Dr. Ham said that they sometimes tease people who stand out and might not fit in, “It’s a way to say ‘I’m part of us and they’re the outsider.’” Dr. Ham recommends that parents encourage their child to reach out for social support from people who understand and believe in them. And, for parents, it’s crucial to reach out to your child’s school for help. “It takes a team effort to stop bullying,” he added. - Jacob Ham, PhD, Assistant Professor, Psychiatry, Director, Center for Child Trauma and Resilience, Icahn School of Medicine at Mount Sinai Learn more: https://sg.news.yahoo.com/12-year-old-nicknamed-trash-girl-bullies-just-wants-make-world- better-place-190713203.html

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200

From: ITNDaily Subject: Mount Sinai In The News - February 28, 2018 Date: Wednesday, February 28, 2018 2:01:21 PM Attachments: ATT00001.txt

In the News February 28, 2018

Crain’s Health Pulse – February 28 Hospital Deaths Lead To Higher Health Costs For Bereaved Spouses — Jonathan LaMantia A person whose spouse dies in the hospital is more likely to incur higher medical costs in the following two years than someone whose spouse dies outside the hospital, according to a new study by a Mount Sinai researcher. The study, published today in Health Services Research, showed the death of a spouse in the hospital was associated with a 50 percent higher risk of an emergency department visit. The findings, while not proving causation, suggest that medical providers must consider the trauma involved when a loved one undergoes high-intensity care, said the study’s author, Katherine Ornstein, PhD, MPH, assistant professor of geriatrics and palliative medicine at the Icahn School of Medicine at Mount Sinai. "We need to think about how end-of-life care impacts families," she said. "We need to think about how we can meet their needs." - Katherine Ornstein, PhD, MPH, Assistant Professor, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai Learn more: http://www.crainsnewyork.com/article/20180228/PULSE/180229884/city-council-bills-wont- move-the-needle-on-opioid-overdoses (Subscription required)

The Chronicle of Philanthropy – February 28 Grants Round-up — M.J. Prest Here are notable new grant awards compiled by The Chronicle: Jack Martin Fund - $2.5 million to Kravis Children's Hospital at Mount Sinai to open a new in-patient unit for pediatric cancer. - Kravis Children’s Hospital at Mount Sinai Learn more: https://www.philanthropy.com/article/Grants-Roundup-Cornell-Gets/242655

WebMD – February 27 How Jim And Jeannie Gaffigan Found Humor In A Crisis — Lauren Paige Kennedy Last year, comedian Jim Gaffigan and his writer wife, Jeannie, faced a health crisis that nearly ended her life, derailed her family, and halted his career. But innovative technology – and a little humor – got them through. When Jeannie developed crushing headaches, frequent falls, and severe fatigue in 2016, she figured she had the flu. After ordering an MRI scan on Jeannie’s head, it revealed a six-centimeter tumor growing within the tightly contained space of her brain stem. While it eventually tested benign, its dimensions and location were particularly dangerous. Had it gone unchecked for even a short time longer, she would have had problems thinking and remembering, paralysis, and very likely death, according to her doctor, Joshua Bederson, MD, professor and system chair of neurosurgery at the Mount Sinai Health System and clinical director of the neurosurgery simulation core. Dr. Bederson ordered Jeannie to undergo an additional seven hours of MRI scans and other imaging tests in the days before her surgery to produce what he calls “a 3D virtual reality simulation of her brain. This cutting edge, augmented reality technology” enabled him to remove the tumor with a high degree of precision “not possible even a year or two ago.” Dr. Bederson and his colleagues use innovative technology that “creates a GPS for the brain,” allowing them to see – and most importantly, avoid – critical parts of the brain with 3D computerized imaging as they remove the tumor. - Joshua Bederson, MD, Professor, System Chair, Department of Neurosurgery, Mount Sinai Health System, Clinical Director, Neurosurgery Simulation Core Learn more: https://www.webmd.com/a-to-z-guides/features/gaffigan-brain-tumor?src=RSS_PUBLIC#1

Bloomberg – February 28 Scientists Want To Completely Rethink How They Make The Flu Vaccine — Cynthia Koons & Ivan Levingston The only thing worse than getting the flu is catching it after you’ve gotten the flu shot, the current shot is just 25 percent effective against the H3N2 virus, this season’s most often-identified strain by the Centers for Disease Control and Prevention. The experts say, with enough time and money, they can do a lot better. GlaxoSmithKline, a leading vaccine developer, is conducting one the first studies of a universal flu vaccine in humans. The shot is based on research directed in part by Peter Palese, PhD, professor and chair of microbiology and professor of medicine and infectious disease at the Icahn School of Medicine at Mount Sinai. Unlike current vaccines that target the constantly changing proteins on the surface of the flu virus, Dr. Palese’s approach targets a part of the virus that remains relatively stable from year to year. - Peter Palese, PhD, Professor, Chair, Microbiology, Professor, Medicine, Infectious Diseases, Icahn School of Medicine at Mount Sinai Learn more: https://www.bloomberg.com/news/articles/2018-02-28/scientists-want-to-completely-rethink- how-they-make-the-flu-vaccine Additional coverage: TIME http://time.com/5179131/the-flu-vaccine-worst-year/

STAT News – February 28 This Scientist Is Testing A Marijuana Ingredient As A Way To Prevent Relapse. It’s A Daunting Task — Megan Thiekling

When Yasmin Hurd, PhD, professor of psychiatry, neuroscience, pharmacology and systems therapeutics at the Icahn School of Medicine at Mount Sinai, chair of Ward-Coleman translational neuroscience, and director of the center for addictive disorders at the Mount Sinai Health System, started collecting brains her peers wondered what she could possibly be thinking. She waved her colleagues off. She wanted to know what was happening in human brains, not in mice. Dr. Hurd saw the opioid crisis coming. Ever since, she’s been trying to figure out how to intervene – could she modify or reverse the way addiction changed the brains being studied in the lab? Dr. Hurd has homed in on , one of the two main compounds plucked from the marijuana plant. She thinks it might hold the potential to curb cravings for and other opioids. Studying cannabidiol is daunting, and not just because the brain is so complex. To use cannabidiol or any part of the cannabis plant for research, a scientist has to get a special license from the Drug Enforcement Administration, which can take years. Then, scientists have to get approval from the Food and Drug Administration to administer it to patients. Dr. Hurd is trying to spur her fellow scientists to do as much research as possible on the potential of cannabidiol to treat opioid addiction, in a bid to build a consortium. Her goal: build an infrastructure that’s far broader than her own. “I don’t need to be the only person in the room studying cannabidiol for opioid addiction,” she said. “It can’t be done with just one little Yasmin Hurd lab.” -Yasmin Hurd, PhD, Professor, Psychiatry, Neuroscience, Pharmacology, Systems Therapeutics, Icahn School of Medicine at Mount Sinai, Chair, Ward-Coleman Translational Neuroscience, Director of the Center for Addictive Disorders, Mount Sinai Health System Learn more: https://www.statnews.com/2018/02/28/marijuana-cannabidiol-opioids-addiction/

CBS New York – February 27 Stem Cells Offer New Hope For Recovery From Rotator Cuff Surgery — Dr. Max Gomez Stem cells have shown promise for all sorts of medical issues for years. You can now add shoulder surgery to that list. It’s for the more than three million Americans who experience rotator cuff injuries each year. Seamus Mullen is a celebrity chef and depends on his arms and hands for his livelihood, so you can only imagine what he felt when a bike accident tore both or his rotator cuffs. Thankfully for Seamus, he was back in the gym just two months after having both shoulders operated on – something most people can’t do for nearly a year post-up. His surgeon credits stem cells for the remarkable recovery. “They have the ability to become the tendon cells, so either they’re becoming tendon cells or producing proteins that recruit other cells that help heal it,” said his surgeon, Aruna M. Seneviratne, MD, assistant professor of orthopaedics at the Icahn School of Medicine at Mount Sinai. “At six months, there’s 100 percent healing and at ten years there’s almost zero re-tears.” The stem cells more than did the trick for Seamus. Just as exciting, the approach has been shown to help other injuries such as tennis elbow, Achilles tendon tears, even knee arthritis. - Aruna M. Seneviratne, MD, Assistant Professor, Orthopaedics, Icahn School of Medicine at Mount Sinai Learn more: http://newyork.cbslocal.com/2018/02/27/stem-cell-rotator-cuff-treatment/

Bergenfield Daily Voice – February 27 Valley-Mount Sinai Offers Breakthrough Breast Cancer Treatment — John Haffey Physicians at Valley-Mount Sinai Comprehensive Cancer Care have begun offering women with early- stage breast cancer a breakthrough treatment. The innovative procedure delivers an entire course of radiation therapy to the patient in the operating room following a lumpectomy, thereby eliminating the need for what is typically weeks of post-surgery radiation. “The IORT procedure uses a miniaturized X- ray source to deliver a full course of targeted radiation from inside the body, directly within the tumor cavity where the cancer is most likely to recur,” said Michael Wesson, MD, clinical assistant professor of radiation oncology at the Icahn School of Medicine at Mount Sinai and co-director of radiation oncology for Valley-Mount Sinai Comprehensive Cancer Care. “This destroys cancer cells while reducing the risk of damage to nearby healthy tissues, including the heart, lungs and ribs.” Chad DeYoung, MD, clinical assistant professor of radiation oncology at the Icahn School of Medicine at Mount Sinai and co-director of radiation oncology for Valley-Mount Sinai Comprehensive Cancer Care said, “This helps minimize potential side effects, which are more common with whole breast irradiation.” - Michael Wesson, MD, Clinical Assistant Professor, Radiation Oncology, Icahn School of Medicine at Mount Sinai, Co-Director, Radiation Oncology, Valley-Mount Sinai Comprehensive Cancer Care - Chad DeYoung, MD, Clinical Assistant Professor, Radiation Oncology, Icahn School of Medicine at Mount Sinai, Co-Director, Radiation Oncology, Valley-Mount Sinai Comprehensive Cancer Care Learn more: http://bergenfield.dailyvoice.com/lifestyle/valley-mount-sinai-offers-breakthrough-breast- cancer-treatment/732266/

Healio – February 28 FDA Clears Study Of Bacteriophages In IBD Treatment— Alex Young Biotech company, Intralytix, has obtained FDA clearance to begin a phase 1/2a study of bacteriophages specifically designed to treat inflammatory bowel disease. Principal investigator, Jean-Frédéric Colombel, MD, professor of medicine and gastroenterology at the Icahn School of Medicine at Mount Sinai and director of the Susan and Leonard IBD Clinical Center at Mount Sinai, said they will take a closer look at bacteriophages that specifically target adherent-invasive Escherichia coli (AIEC), a strain of bacteria that is regularly found in the mucosa of patients with Crohn’s disease. “Several therapeutic strategies targeting AIEC colonization have been proposed to slow or even halt the natural course of CD,” Dr. Colombel said. “Manipulation of the patient’s microbiota through antibiotic treatment, fecal transplantation, nutritional interventions or the administration of pre/probiotics could be used either alone or in combination with immunotherapy, to induce the remission of active disease or as a postoperative treatment to prevent relapse. However, the results obtained to date have been inconsistent.” - Jean-Frédéric Colombel, MD, Professor, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai, Director, Susan and Leonard Feinstein IBD Clinical Center at Mount Sinai Learn more: https://www.healio.com/gastroenterology/inflammatory-bowel- disease/news/online/%7Bcce06bf2-4708-4388-95cc-d9f189a54052%7D/fda-clears-study-of-bacteriophages- in-ibd-treatment Additional coverage: Everyday Health https://www.everydayhealth.com/crohns-disease/treatment/fda-clears-clinical-studies- new-bacteriophage-treatment-crohns-disease/

Reader’s Digest – February 27 The Newest Psoriasis Treatments Will Have You Wearing Short Sleeves Again — Denise Mann, MS While there is still no cure for psoriasis, new treatments now allow millions of people who live with this inflammatory skin condition to sport short sleeves once again. “For the first time ever, the newest biologics can take someone from having psoriasis to no psoriasis. They are completely clear,” said Mark Kauffman, MD, associate clinical professor of dermatology at the Icahn School of Medicine at Mount Sinai. Given by shot or intravenous infusion, biologics are reserved for people with moderate to severe psoriasis. The newest crop of biologics gets even more specific in their aim, making them that much more effective and safe. They are even effective if someone has tried and failed or stopped responding to older biologics. There are also new biologics being investigated that may be even more targeted, Dr. Kauffman predicts. "It's plausible in next five years, we will have biologics that are given once a year and then you will have no psoriasis for rest of the year. It's the most incredible time in the treatment of psoriasis." - Mark D. Kaufmann, MD, Associate Clinical Professor, Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.rd.com/health/conditions/new-psoriasis-treatments/

Reader’s Digest – February 27 12 Everyday Habits That Secretly Slow Your Metabolism — Teresa Dumain The last thing you want to do is stand in the way of your body burning calories. Muscle tissue is the source of your resting metabolic rate, said Jeffrey Mechanick, MD, clinical professor of medicine, endocrinology, diabetes and bone disease, director of metabolic support at the Icahn School of Medicine at Mount Sinai and medical director of the Marie-Josee and Henry R. Kravis Center for Cardiovascular Health at Mount Sinai Heart. That’s the number of calories your body uses to keep your heart beating, lungs pumping, and all the other necessary functions that keep our body healthy. So it stands to reason: the more muscle you have, the higher your metabolic rate and the more calories you burn. As we age, we lose muscle and gain fat. To counteract those effects, include strength training in your regimen. - Jeffrey Mechanick, MD, Clinical Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Director, Metabolic Support, Icahn School of Medicine at Mount Sinai, Medical Director, The Marie- Josee and Henry R. Kravis Center for Cardiovascular Health, Mount Sinai Heart Learn more: https://www.rd.com/health/healthy-eating/slow-metabolism/

New York Daily News – February 27 How To Fight Heart Disease – The Number One Killer Of Women — Beth Oliver, DNP, RN Heart disease is the number one killer of women, both in the United States and worldwide. Heart disease causes one of every three deaths among women is the United States. Beth Oliver, DNP, RN, senior vice president of cardiac services for the Mount Sinai Health System said, “One of the challenges we face is that women may experience different symptoms of heart disease than men. Women may not always have crushing chest pain. Sometimes their only symptoms are feelings of extreme fatigue, shortness of breath, or abdominal discomfort.” It is crucial to take steps to protect your heart health long before an emergency can arise. “We need to start taking charge of our own heart health. When it comes to our hearts, an ounce of prevention is worth a pound of cure.” - Beth Oliver, DNP, RN, Senior Vice President, Cardiac Services, Mount Sinai Health System Learn more: http://www.nydailynews.com/life-style/fight-heart-disease-no-1-killer-women-article- 1.3845679

Medscape – February 28 Pregnancy Apps: Useful Or Useless? — Tara Haelle As many as four in five U.S. women of childbearing age have a smartphone, and about one fourth of these women use health apps, according to Katherine T. Chen, MD, professor and system vice chair of education in the department of gynecology, obstetrics and reproductive science at the Icahn School of Medicine at Mount Sinai. Among more than 90,000 apps in the Apple iTunes store, seven percent focus on women’s health and pregnancy. These apps, which number in the thousands, aim to capture the attention of pregnant women by offering tools for everything from tracking fetal development to timing contractions. "Apps are becoming more patient-centered," said Dr. Chen, who studies ob/gyn-related mobile apps. Although she focuses on apps for clinicians, Dr. Chen sees growing interest in apps that help pregnant women track their health and communicate with providers. App overload and inaccuracy are the two biggest problems with health apps, said Dr. Chen, whose research has found high levels of inaccuracy in some women's health apps. - Katherine T. Chen, MD, Professor, System Vice-Chair, Education, Department of Gynecology, Obstetrics and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.medscape.com/viewarticle/892945

Cosmopolitan – February 27 What Is PPMD? — Hannah Smothers Premenstrual dysphoric disorder (PMDD), which is essentially an extreme version of PMS that comes with symptoms similar to clinical depression. Like PMS, PMDD is tied to the menstrual cycle, but PMDD is severe enough to have a negative effect on your everyday life. Shari Lusskin, MD, clinical professor of psychiatry, obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai said "up to 80 percent of women have premenstrual syndrome" and experience mood and body changes, like bloating and breast tenderness. "But they don't meet the criteria for PMDD, which is defined as having at least thirty percent worsening — you have to have a significant decrease in mood with a substantial impact on functioning." To identify a pattern, Dr. Lusskin said your doctor will ask you to track your symptoms in real time instead of retrospectively. The doctor is looking to rule out symptoms that last all month long but get worse around the time of your period, which technically would be something more like depression or panic disorder than PMDD. - Shari Lusskin, MD, Clinical Professor, Psychiatry, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.cosmopolitan.com/sex-love/a18735059/pmdd-symptoms-treatment-facts/

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - February 27, 2018 Date: Tuesday, February 27, 2018 3:26:54 PM Attachments: ATT00001.txt

In the News February 27, 2018

Crain’s Health Pulse – February 27 Mount Sinai Receives $2.5 Million For Children’s Cancer Unit — Caroline Lewis Mount Sinai Health System is naming a new pediatric cancer unit at Kravis Children's Hospital after the Jack Martin Fund after receiving a $2.5 million gift from the foundation, the health system said Monday. The fund, established in 1950 by the family and friends of a business executive who died of polio, has contributed more than $36 million to Mount Sinai over the years. The pediatric hematology-oncology division the unit is a part of is also named for Jack Martin. Mount Sinai is holding a ribbon-cutting today for the 5,300-square-foot Jack Martin Fund Inpatient Unit for Children's Cancer and Blood Disease, which will feature eight private beds, including two isolation rooms, as well as a family lounge and playroom. "Through our alliance with Children's Hospital of Philadelphia and the co-managed Children's Cancer Program, we have expanded our pool of nationally recognized experts and are increasing the scope of clinical services in order to provide the most advanced care for children battling cancer and blood disease," said Kenneth L. Davis, president and CEO of Mount Sinai Health System. - Kenneth L. Davis, MD, President, CEO, Mount Sinai Health System Learn more: http://www.crainsnewyork.com/article/20180227/PULSE/180229908/nomad-health-raises- 12m-in-latest-round (Subscription required). Additional coverage: Politico New York https://www.politico.com/states/new-york/newsletters/politico-new-york-health- care/2018/02/27/med-mar-back-in-court-038994

Bisnow – February 26 Large Hospitals Shrink As Medical Tech Leads To More Outpatient, Specialty Care Clinics — Lara O’Keefe Medical facilities are becoming smaller and more specialized to help minimize costs for both patients and hospitals. Outpatient clinics are becoming an increasingly popular option for care. The facilities, which include same-day surgery center and microhospitals, are popping up all over the country. Mount Sinai Health System now offers a network of specialty services at different sites, including urgent care, outpatient-surgery, and behavioral services. Mount Sinai has taken this approach with a number of its facilities and is focused on converting many of its hospitals to specialty care building that can still offer emergency services when needed. In addition to improved technology, part of the reason for this shift is the fact that the U.S. is home to more hospital beds than needed. In microhospitals, approximately 92 percent of patients are able to be treated and sent home in under two hours, limiting both risk of infection and medical costs. - Mount Sinai Health System Learn more: https://www.bisnow.com/national/news/healthcare/sprawling-hospitals-are-becoming- smaller-85452

WCBS News Radio – February 27 Health And Well Being: Surgery Without Scars — Pat Farnack If a thyroid has to be removed, large scars in the neck can be avoided with a BABA robotic procedure. Hyunsuk Suh, MD, assistant professor of surgery at the Icahn School of Medicine at Mount Sinai said “BABA stands for bilateral axillo-breast approach robotic thyroidectomy, which means that instead of having a conventional surgery for thyroid where you make an incision in the neck, which is quite visual, you make four small incisions at the skin fold at the armpit and the breast where the incisions are hidden. So once they heal, it becomes nearly invisible.” He added, “The typical patient that has thyroid disease can be treated with the BABA procedure.” - Hyunsuk Suh, MD, Assistant Professor, Surgery, Icahn School of Medicine at Mount Sinai Learn more: http://newyork.cbslocal.com/audio/health-and-well-being/

Scientific American – February 27 Getting To The Root Of The Problem: Stem Cells Are Revealing New Secrets About Mental Illness — Dina Fine Maron Millions of Americans who suffer from bipolar disorder depend on lithium. The medication has been prescribed for half a century to help stabilize patients’ moods and prevent manic or depressive episodes. Yet what it does in the brain—and why it does not work for some people—has remained largely mysterious. Researchers have uncovered new details about how lithium may alter moods. The team used established lab techniques to reprogram patients’ skin cells into stem cells capable of becoming any other kind – and then chemically coaxed them into becoming brain cells. This process is now providing the first real stand-ins for brain cells from mentally ill humans, allowing for unprecedented direct experiments. The team obtained ordinary skin cells from people in both groups, and transformed those samples into iPSCs and then brain cells. “When you reprogram cells into iPSCs they lose all markers of age, regardless of how old the person is,” said Kristen Brennand, PhD, associate professor of neuroscience, psychiatry, genetics and genomic sciences at the Icahn School of Medicine at Mount Sinai, who was not involved in the work. “We can look at disease risk in a dish without any impact of things like drug abuse or adolescent trauma or infection of the mother while pregnant—so all we have is the genetic risk that was there when sperm met egg.” - Kristen Brennand, PhD, Associate Professor, Neuroscience, Psychiatry, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai Learn more: https://www.scientificamerican.com/article/getting-to-the-root-of-the-problem-stem-cells- are-revealing-new-secrets-about-mental-illness/

BioMed Central – February 26 Research On Rare Genetic Disorders Informs Autism And Leads To Better Clinical Care— Silvia De Rubeis, PhD Rare genetic neurodevelopmental disorders are often associated with autism spectrum disorder (ASD). Silvia De Rubeis, PhD, assistant professor of psychiatry and neurodevelopment disorders researcher at the Mindich Child Health and Development Institute at the Icahn School of Medicine at Mount Sinai shares some of the latest research on rare genetic diseases associated with autism and explains how it is benefiting treatment strategies, improving clinical trials and increasing our knowledge of autism. The Seaver Autism Center at Mount Sinai is currently conducting research and leading studies on five rare genetic disorders associated with ASD and intellectual disability. “For all these disorders, we have both a pre-clinical and a clinical program in place. We take an inter-disciplinary and translational approach: genetic findings are translated in cell and rodent models, which are then used to investigate the basic mechanisms of the disorders,” said Dr. De Rubeis. In summary, understanding rare genetic disorders associated with ASD is important to improve clinical care and optimize treatment strategies for these debilitating conditions. - Silvia De Rubeis, PhD, Assistant Professor, Psychiatry, Neurodevelopment Disorders Researcher, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai Learn more: http://blogs.biomedcentral.com/on-biology/2018/02/26/research-on-rare-genetic-disorders- informs-autism-clinical-care-rare-disease-day/

Skilled Nursing News – February 26 Targeting Seniors In The ER Can Bolster Partnerships, Reap Savings — Maggie Flynn Emergency departments could play a key role in care transitions for older patients and lead to overall Medicare savings, according to a study published in the Journal of the American Geriatrics Society. More generally, focusing on seniors in the ED could also lead to better relationships between hospitals and skilled nursing facilities. “The emergency department is that intersection of patients where it’s their last resort of care, whether it’s because of truly an emergency or because they don’t have access to care,” said corresponding author Ula Hwang, MD, associate professor of emergency medicine, geriatrics and palliative medicine at the Icahn School of Medicine at Mount Sinai. Even though older patients with multiple medical issues are coming to the emergency room, hospitals should avoid the “knee-jerk reflex that everyone needs to be admitted,” she said. - Ula Hwang, MD, Associate Professor, Emergency Medicine, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://skillednursingnews.com/2018/02/targeting-seniors-er-can-bolster-partnerships-reap- savings/

NBC News: Today – February 26 Man’s New Life Post Eight-Pound Tumor Removal The tumor doctors call the most extreme and complicated they’ve ever seen is finally gone from Lucas McCulley’s face. It took more than seven hours at the New York Eye and Ear Infirmary at Mount Sinai last Fall to remove the mass – the 25th operation McCulley has endured in his life. He was born with lymphangioma, a non-cancerous congenital tumor on the right side of his face likely caused by a random genetic mutation. Gregory Levitin, MD, director of vascular birthmarks and malformations at the New York Eye and Ear Infirmary of Mount Sinai, performed the surgery last October. He called it the most challenging he’s ever seen. Dr. Levitin was able to remove 80 percent of the mass, but left behind a “shelf of tumor” that is holding up McCulley’s right eye. The most important aspect of the surgery is that McCulley is pain-free now. - Gregory M. Levitin, MD, Senior Faculty, Otolaryngology, Icahn School of Medicine at Mount Sinai, Director, Vascular Birthmarks and Malformations, New York Eye and Ear Infirmary of Mount Sinai - Joseph Rousso, MD, Associate Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai, Facial Plastic Surgeon, New York Eye and Ear Infirmary of Mount Sinai Learn more: https://www.today.com/health/idaho-man-face-tumor-reveals-surgery-results-t123934 Additional coverage: KTVB News http://www.ktvb.com/article/news/local/lucas-mcculley-reveals-himself-post-surgery/277- 523567995 People Health http://people.com/health/man-facial-tumor-removed-pain-free/ Idaho State Journal https://idahostatejournal.com/news/local/south-idaho-man-undergoes-surgery-to- treat--pound-facial/article_20001ee2-1439-55b4-9b7e-99222efb9088.html 11 Alive http://www.11alive.com/article/news/local/lucas-mcculleys-post-surgery-look-revealed-it-feels- like-i-have-got-a-new-life/85-523675872 The Doctors TV https://www.thedoctorstv.com/videos/man-s-new-life-post-8-pound-tumor-removal LittleThings https://www.littlethings.com/lucas-8-pound-tumor/

The ASCO Post – February 25 Stand Up To Cancer Awards $11 Million To Study Immune Response To Cancer Stand Up To Cancer (SU2C) has announced a “Convergence 2.0” research initiative that awards $11 million to seven multidisciplinary research teams to investigate immune system response to cancer. The multi-institutional teams were announced at SU2C’s Scientific Summit. Each team comprises experts in life sciences, physical sciences, mathematics, and engineering and will have the opportunity to work collaboratively with Microsoft’s machine learning experts to discover key aspects of the interaction between cancer and the immune system. In addition to support from Microsoft, the Lustgarten Foundation for Pancreatic Cancer Research committed $1.76 million in funding, and the Society for Immunotherapy of Cancer will provide one million to support postdoctoral fellows on several teams. The Computational Deconstruction of Neoantigen-TCR Degeneracy for Cancer Immunotherapy team, led by Benjamin Greenbaum, MD, assistant professor of medicine, hematology, medical oncology, pathology, and oncological sciences at the Icahn School of Medicine at Mount Sinai will explore the underpinnings of pancreatic cancer survivorship. - Benjamin D. Greenbaum, MD, Assistant Professor, Medicine, Hematology and Medical Oncology, Pathology, Oncological Sciences, Icahn School of Medicine at Mount Sinai Learn more: http://www.ascopost.com/issues/february-25-2018/stand-up-to-cancer-awards-11m-to-study- immune-response-to-cancer/

Specialty Pharmacy Times – February 26 New Study Explores Potential Of Mediterranean Diet In Multiple Sclerosis — Laurie Toich Researchers and health experts alike have reported significant benefits from the Mediterranean diet, which emphasizes plant-based foods, healthy fats, and fish. Several studies suggest the diet can improve health among patients with various diseases, including rheumatoid arthritis, diabetes, and multiple sclerosis (MS). A new study conducted by researchers from the Icahn School of Medicine at Mount Sinai is exploring the role of gut bacteria in inflammation and . Specifically, they are investigating how a modified Mediterranean diet may help lessen the symptoms of MS. “We want to better understand the inflammatory process, the neurodegenerative process, and the effect that diet has on MS symptoms,” said lead researcher, Ilana Katz Sand, MD, assistant professor of neurology at the Icahn School of Medicine at Mount Sinai and associate medical director of the Corinne Goldsmith Dickinson Center for Multiple Sclerosis. “Our findings could be very important in understanding the onset of MS and how to treat it.” - Ilana Katz Sand, MD, Assistant Professor, Neurology, Icahn School of Medicine at Mount Sinai, Associate Medical Director, The Corinne Goldsmith Dickinson Center for Multiple Sclerosis Learn more: https://www.specialtypharmacytimes.com/news/new-study-explores-potential-of- mediterranean-diet-in-multiple-sclerosis

Futurity – February 25 Human Genome’s Frontier May Hold Keys To New Drugs — Andreas Westergaard The development of new drugs currently focuses on just 60 percent of potential drug targets, a new study indicates. The study, which builds on extensive data analysis, conducted using super computers—a technique called data mining—has examined huge amounts of literature within the health and medical sciences and other evidence sources in order to identify both the most and least studied proteins for drug targets. The research could pave the way for new so-called repositioning opportunities, where already approved drugs can be tested on new factors. This means that proteins in drugs only approved for one therapy could be tested for the treatment of other diseases. The analysis is based on research collaboration among the NIH National Center for Advancing Translational Sciences; Novo Nordisk Foundation Center for Protein Research; University of Copenhagen; the European Bioinformatics Institute; and the Icahn School of Medicine at Mount Sinai. - Icahn School of Medicine at Mount Sinai Learn more: http://www.futurity.org/human-genome-analysis-drug-discovery-1687832/

MedPage Today – February 26 AAD Poster Rounds: Many Psoriasis Patients Use Multiple Drugs An initial analysis of 842 psoriasis patients included in the industry-sponsored Corrona registry indicated that a substantial minority take more than one biologic medication to control their disease. Lauren Bonomo, MD, clinical research fellow in the department of dermatology at the Icahn School of Medicine at Mount Sinai, and colleagues identified 92 patients in the registry using biologic combination therapy. Although the data did not indicate the specific reasons in individual patients, analysis of patients' characteristics revealed a number of group differences between those on combination therapy versus those using single agents. The research was presented at the American Academy of Dermatology annual meeting in San Diego. Eventually the Corrona registry is anticipated to enroll a total of 12,000 patients, which may shed more light on the safety and efficacy of real-world therapies, the researchers indicated. - Lauren Bonomo, MD, Clinical Research Fellow, Department of Dermatology, Icahn School of Medicine at Mount Sinai Learn more: https://www.medpagetoday.com/meetingcoverage/aadposterrounds/71390

Oprah Magazine – February 26 How To Avoid Straining Your Eyes If You Stare At A Computer All Day — Rachel Morris Working your eyes too hard can lead to eyestrain, that must-close-my-lids sensation often accompanied by blurred vision, headaches and neck pain, said Avnish Deobhakta, MD, assistant professor of vitreoretinal surgery and ophthalmology at the Icahn School of Medicine at Mount Sinai. When you look at your computer screen, the ciliary muscle in your eye changes the shape of your lens to bring emails or spreadsheets into focus. And just like any other muscle, the ciliary gets fatigued if engaged for too long, said Dr. Deobhakta. At least once an hour, give it a break by gazing off into the middle distance for two or three minutes. The ciliary muscle has to work overtime to focus the eye against too-bright light, added Dr. Deobhakta. Fiddle with the brightness, position, and tilt of your screen to see whether it makes a difference in how your eyes feel. - Avnish Deobhakta, MD, Assistant Professor, Vitreoretinal Surgery, Ophthalmology, Icahn School of Medicine at Mount Sinai Learn more: http://www.oprah.com/health_wellness/how-to-avoid-eye-strain-at-work

HealthDay – February 26 15 Percent Of Teens Say They’ve Sexted — Dennis Thompson About 15 percent of teenagers say they've shared a sexually explicit image or video of themselves over the internet or via phone messaging, researchers say. Sexting between teenagers is increasing with the widespread use of camera-equipped smartphones and computers. "I believe most teens do not appreciate the reality that once messages or photos are out in the world, there is no way of controlling how they are used or who they are forwarded to," said Elizabeth Ochoa, PhD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai and chief psychologist at Mount Sinai Beth Israel. "Reputations can be compromised for years to come, the result of sending an impulsive, sexually explicit message or photograph," she added. She said that parents should discuss the potential legal ramifications of sexting. In some states, teens could face felony charges for sexting a photo of themselves, and might even have to register as a sex offender. - Elizabeth Ochoa, PhD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai, Chief Psychologist, Mount Sinai Beth Israel Learn more: Additional coverage: https://consumer.healthday.com/pregnancy-information-29/love-sex-and- relationship-health-news-452/15-percent-of-teens-say-they-ve-sexted-731441.html U.S. News & World Report https://health.usnews.com/health-care/articles/2018-02-26/15-percent-of-teens- say-theyve-sexted Health Magazine http://www.health.com/healthday/15-percent-teens-say-theyve-sexted Doctors Lounge https://www.doctorslounge.com/index.php/news/hd/78668 WebMD https://www.webmd.com/parenting/news/20180226/15-percent-of-teens-say-theyve-sexted UPI https://www.upi.com/Health_News/2018/02/26/Study-15-percent-of-teens-say-theyve- sexted/9401519679890/ Medical Xpress https://medicalxpress.com/news/2018-02-percent-teens-theyve-sexted.html Drugs.com https://www.drugs.com/news/15-percent-teens-say-they-ve-sexted-68815.html? utm_source=ddc&utm_medium=rss&utm_campaign=15+Percent+of+Teens+Say+They%27ve+Sexted

Self Magazine – February 26 Chrissy Teigen Says She’s Worried About Developing Postpartum Depression Again — Emily Wang Chrissy Teigen has been open about her experience with postpartum depression after the birth of her daughter in 2016 – and that she initially dismissed her symptoms. Now, this past weekend, the supermodel revealed that she’s worried the condition may resurface when she gives birth to her son in June. Thankfully, there are steps pregnant patients can take to lower the risk for repeated PPD. “It’s not a bad idea to touch base with a therapist,” said Michel Silverman, PhD, assistant professor of psychiatry at the Icahn School of Medicine at Mount Sinai. “That doesn’t necessarily mean you have to get back into therapy, but just have a plan.” Getting good sleep, balanced nutrition, and regular physical activity is also especially important to keep you healthy mentally and physically at this time. - Michael Silverman, PhD, Assistant Professor, Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.self.com/story/chrissy-teigen-worried-about-getting-postpartum-depression- again

Allure Magazine – February 26 How To Tell If Your Little Red Facial Bump Is A Pimple Or A Cold Sore — Kaleigh Fasanella If you’ve ever had a pimple pop up in close vicinity to your mouth, chances are you’ve wondered if said blemish could actually be a cold sore. In actuality, pimples and cold sores share very little in common, making them pretty easy to distinguish from one another once you know what to look for. The cluster can look like a small group of pimples, though, as the skin around the area will be quite inflamed and will quickly form a scabby appearance, said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at The Mount Sinai Hospital. The first time someone gets a cold sore, it can last anywhere from two to four weeks, and after that first time will typically resolve itself in a week or two. Because cold sores are sparked by a virus, they need to be treated with antiviral medications, which can sometimes curb them from occurring altogether. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.allure.com/story/identify-herpes-cold-sore-vs-pimple

Metro NY – February 26 Seasonal Allergies: What’s Causing Your Dry Eye & Runny Nose This Winter? — Sheila Dougherty In the U.S., we’ve been experiencing the worst flu season in a decade; as of last week, 97 children have died of the illness. Influenza has been grabbing all the headlines, but our eyes, ears, noses, and throats experience all sorts of trouble this time of year. Gregory Levitin, MD, otolaryngologist and director of the vascular birthmarks and malformations program at the New York Eye and Ear Infirmary of Mount Sinai and Angie Wen, MD, cornea and cataract surgeon at the New York Eye and Ear Infirmary of Mount Sinai, talk about the differences among the illnesses we commonly experience this year, and how best to care for ourselves. “Cold and flu season refers to the winter months when respiratory viruses are most prevalent. Many people are actually sensitive to cold weather, a condition called vasomotor rhinitis, and develop symptoms similar to that of allergic rhinitis, which can occur year-round,” said Dr. Levitin. Dr. Wen added, “Many decongestants and antihistamines can cause dry eye in the same way that they dry out the mucous membranes of the nose.” - Gregory M. Levitin, MD, Senior Faculty, Otolaryngology, Icahn School of Medicine at Mount Sinai, Director, Vascular Birthmarks and Malformations, New York Eye and Ear Infirmary of Mount Sinai - Angie Wen, MD, Assistant Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Cornea and Cataract Surgeon, New York Eye and Ear Infirmary of Mount Sinai Learn more: https://www.metro.us/body-and-mind/health/winter-allergies-dry-eye

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - February 26, 2018 Date: Monday, February 26, 2018 1:20:47 PM Attachments: ATT00001.txt

In the News February 26, 2018

The Wall Street Journal – February 25 What The Hospitals Of The Future Look Like — Laura Landro The days of the hospital as we know it may be numbered. In a shift away from their traditional inpatient facilities, health-care providers are investing in outpatient clinics, same-day surgery centers, free- standing emergency rooms and microhospitals, which offer as few as eight beds for overnight stays. Mount Sinai Health System has developed a hospital-at-home program, HaH-plus, for some patients who show up at the emergency department or are referred by their primary-care doctors. “For some admissions, we can avoid the emergency department, but for most admissions like pneumonia, dehydration or a skin infection, we evaluate them in the ED and then send them home in an ambulance with an IV in place,” said Linda DeCherrie, MD, clinical director of the mobile acute care team of Mount Sinai’s Hospital at Home Program. Mount Sinai estimates that nationally, 575,000 cases each year could qualify for such a program, and treating just 20 percent of those could save Medicare $45 million annually. Mount Sinai is working with Contessa Health, which manages bundled-payment arrangements for hospital-at-home services, and plans to expand the home program to other areas, such as patients recovering from surgeries that would typically require an inpatient stay. “The goal is to care for each patient in the most appropriate setting, whether in a traditional hospital bed, an outpatient center or at home,” said Kenneth L. Davis, MD, president and CEO of the Mount Sinai Health System. - Kenneth L. Davis, MD, President, CEO, Mount Sinai Health System - Linda V. DeCherrie, MD, Associate Professor, Medicine, Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, Clinical Director, Mobile Acute Care Team, Mount Sinai’s Hospital at Home Program Learn more: https://www.wsj.com/articles/what-the-hospitals-of-the-future-look-like-1519614660

The New York Times – February 23 Am I Going Blind? — Frank Bruni An estimated one million Americans are legally blind, meaning that their corrected vision is no better than 20/200. A few million more have life-altering vision impairment. Just a tiny minority of both groups were born that way. The rest lost their sight after seeing perfectly well. Frank Bruni experienced what is called “a stroke of the eye,” whereby the optic nerve is ravaged by a brief reduction of blood flow and thus, oxygen. The name for this condition is nonarteritic anterior ischemic optic neuropathy (N.A.I.O.N), and it afflicts perhaps one in 10,000 Americans. Rudrani Banik, MD, associate professor of ophthalmology at the Icahn School of Medicine at Mount Sinai and an ophthalmologist at the New York Eye and Ear Infirmary of Mount Sinai, one of the neuro-ophthalmologists who monitored Bruni during a clinical trial, told Bruni to think of the nerve and its surrounding sheath as “a cable within a pipe.” Bruni’s pipe, she explained, is a quarter of the normal size, so if the nerve swells – as nerves do when bereft of oxygen – it’s more likely to press up against the pipe and be hurt. “Everything is congested,” she said. “Anatomically, we call it a disc at risk. I hate to use that term because it scares patients.” - Rudrani Banik, MD, Associate Professor, Ophthalmology, Icahn School of Medicine at Mount Sinai, Ophthalmologist, The New York Eye and Ear Infirmary of Mount Sinai Learn more: https://www.nytimes.com/2018/02/23/opinion/eyesight-going-blind.html

John Batchelor Show – February 25 Neanderthals And Breastfeeding — Michael Balter A team led by Manish Arora, BDS, MPH, PhD, director of exposure biology and associate professor of environmental medicine and public health at the Icahn School of Medicine at Mount Sinai, hypothesized that it might be possible to detect when a child was weaned from the amount of barium in its growing teeth. Barium is an element similar to calcium and is present in water sources and many types of soils. The teeth begin growing before birth, but while a child is still in the womb the placenta blocks most barium – but no calcium – from reaching their dentine and enamel. After birth, barium in breast milk can more easily reach the teeth; and when a human baby is switched to infant formula, even more barium enters the teeth, because both cow- and soy-based formulas contain higher levels of the element than breast milk. Then, when the child switches from formula to solid food, the barium level goes back down. - Manish Arora, BDS, MPH, PhD, Director of Exposure Biology, Associate Professor, Environmental Medicine, Public Health, Icahn School of Medicine at Mount Sinai Learn more: https://audioboom.com/posts/6692589-neanderthals-and-breastfeeding-michael-mbalter

MD Alert – February 23 Prognostic Value Of Multigene Signatures Vary In Node-Negative Breast Cancer — Marilynn Larkin For women with node-negative breast cancer, a combination of clinical findings and molecular information from the ROR, BCI and EPclin multigene signatures has significantly more prognostic value for overall and late-distant recurrence than the IHC4, RS and CTS signatures, researchers say. Charles Shapiro, MD, director of cancer survivorship and translational breast cancer research at the Tisch Cancer Institute and professor of medicine at the Icahn School of Medicine at Mount Sinai noted, “The two best scores, the ROR and the BCI, were not that different, with nearly overlapping 95 percent confidence intervals.” He added that the tests are useful if you are low risk, with a ten-year risk of distance recurrence of five percent or less. “You may choose to not take any treatment, especially an aromatase inhibitor that is taken for five years and has potential side effects that may make a big impact on your daily quality of life.” - Charles Shapiro, MD, Director, Cancer Survivorship, Translational Breast Cancer Research, The Tisch Cancer Institute, Professor, Medicine, Icahn School of Medicine at Mount Sinai Learn more: http://www.mdalert.com/news/article/prognostic-value-of-multigene-signatures-vary-in- node-negative-breast-cancer

Healio – February 23 Digital Sensor In Antipsychotic May Improve Medication Adherence — Savannah Demko In November 2017, the FDA approved Abilify MyCite, aripiprazole tablets with an ingestible sensor that digitally tracks whether patients have taken their medication, for the treatment of schizophrenia, manic and mixed episodes associated with bipolar I disorder and as an add-on treatment for depression. Intended to enhance medication compliance in these patients, the tracking system works by sending a message from the pill's sensor to a wearable patch that transmits the information to a mobile app patients can access from their smartphone. “For some persons with severe mental illness, being adherent to medications means the difference between being institutionalized or receiving outpatient care, so there are some important opportunities for this new formulation,” said Dolores Malaspina, MD, MPH, director of the psychosis program in the department of psychiatry at the Icahn School of Medicine at Mount Sinai. “An important cause of noncompliance is also executive brain dysfunction that causes persons to forget the medication and a pill with a sensor will be helpful.” - Dolores Malaspina, MD, MPH, Director, Psychosis Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/psychiatry/schizophrenia/news/online/%7Beb5f5a01-866e-49f5- 934c-560a6ea3ba7d%7D/digital-sensor-in-antipsychotic-may-improve-medication-adherence

Allure Magazine – February 23 The New PiQo4 Laser Is A Hyperpigmentation Treatment For All Skin Tones — Macaela Mackenzie There’s a new laser treatment in town. Unveiled earlier this month at the American Academy of Dermatology annual meeting in San Diego, the PiQo4 laser is upping the ante for skin-care tech. For surface-level treatment, “the laser works by punching microscopic holes in the skin, creating a controlled wound,” said Joshua Zeichner, MD, assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai and director of cosmetic and clinical research in dermatology at the Mount Sinai Hospital. “As the skin heals from this controlled injury, it does so in a healthier and cosmetically elegant manner.” What is most notable about the PiQo4 laser are the four different wavelengths of light it uses. Currently, not all lasers on the market are suitable for darker skin tones, but the new laser works on all skin tones. - Joshua Zeichner, MD, Assistant Professor, Dermatology, Icahn School of Medicine at Mount Sinai, Director, Cosmetic and Clinical Research in Dermatology, The Mount Sinai Hospital Learn more: https://www.allure.com/story/piqo4-laser-treatment-hyperpigmentation-before-after-photos

Reader’s Digest – February 26 15 Everyday Habits That Could Add Five Years To Your Life — Tina Donvito These healthy activities have been scientifically shown to help you stick around longer. A recent study showed dog owners were 33 percent less likely to die early. “Dogs have been shown to improve longevity and reduce heart disease, but the mechanism of why is unclear,” said Shanna Levine, MD, instructor of general internal medicine at the Icahn School of Medicine at Mount Sinai. It could be because owners take their dogs for frequent walks and therefore get more exercise. Research also shows that those who eat a Mediterranean diet have longer telomeres, the protective caps on the end of chromosomes, which slows aging. “Ideally everyone should eat five serving of fruits and vegetables a day,” said Dr. Levine. “This equals ½ cup of cooked vegetables or one cup of raw vegetables.” - Shanna Levine, MD, Instructor, Medicine, General Internal Medicine, Icahn School of Medicine at Mount Sinai Learn more: https://www.rd.com/health/wellness/habits-for-long-life/

Self Magazine – February 23 Dehydration Can Cause Contractions During Pregnancy — Korin Miller Pregnancy is filled with weird aches, pains, and twinges and some are a little scarier than others. Former Bachelorette star Ali Fedotowsky recently had a particularly confusing experience with pregnancy pain – and it was so bad that she thought she was going into pre-term labor. This kind of thing is surprisingly common during pregnancy. The American College of Obstetricians and Gynecologists specifically says on its website that dehydration in pregnancy has been linked with a small increase in uterine contractions. “Labor contractions make your cervix dilate,” said Fahimeh Sasan, DO, assistant professor of obstetrics, gynecology and reproductive science at the Icahn School of Medicine at Mount Sinai. “But when a pregnant woman is dehydrated, her uterine muscles can just contract, but she’s not actually in labor.” She added that any pregnant woman with any pain should be evaluated and should never assume everything is fine. So, even if you do drink water and the pain goes away, you should still check in with your doctor afterward. - Fahimeh Sasan, DO, Assistant Professor, Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai Learn more: https://www.self.com/story/dehydration-can-cause-contractions-during-pregnancy-as- bachelorette-star-ali-fedotowsky-just-found-out

Health Magazine – February 23 Kourtney Kardashian Weighs 98 Pounds, Here’s Why That’s Not Necessarily A Bad Thing — Sarah Klein The number on the scale varies greatly with our own individual packaging, so to speak – which in Kourtney Kardashian’s case is small. Depending on bone structure, muscle mass, and genetics, a range for healthy women of five feet could be anywhere from the low 90s to the 120s. Reshmi Srinath, MD, assistant professor of medicine, endocrinology, diabetes and bone disease and director of weight and metabolism management program at the Icahn School of Medicine at Mount Sinai, said she typically looks at a person’s BMI or body mass index rather than just the number on the scale – and even those don’t provide a perfect measure. “BMI is a standardized measure of height compared to weight, and using that, I can characterize someone as normal weight, underweight, or reaching obesity,” she explained. - Reshmi Srinath, MD, Assistant Professor, Medicine, Endocrinology, Diabetes and Bone Disease, Director, Weight and Metabolism Management Program, Icahn School of Medicine at Mount Sinai Learn more: http://www.health.com/weight-loss/kourtney-kardashian-weight-98-pounds

If you have a news story, news tip, breakthrough, study, upcoming event or patient success story to share or have been contacted by the media for an interview contact: [email protected] 212-241-9200 From: ITNDaily Subject: Mount Sinai In The News - February 23, 2018 Date: Friday, February 23, 2018 12:51:10 PM Attachments: ATT00001.txt

In the News February 23, 2018

Amsterdam News – February 22 New York Urban League Honors Champions Of Diversity The New York Urban League (NYUL) recognizes companies and respected leaders who have exemplary diversity practices in the areas of leadership, hiring and promotion, supplier diversity and philanthropy at its 15th annual Champions of Diversity Awards Breakfast. The NYUL also bestowed three Champions of Diversity Awards for Exemplary Best Practices. Individuals and their companies who are presented with this award have recognized that diversity is not a one-time hire or creation of affinity groups, but a daily commitment to inclusive best practices. Mount Sinai Health System was honored along with L’Oréal and Major League Baseball, for continuing to champion the cause of diversity, and for the ability to respond to issues of gender and race in real time. - Mount Sinai Health System Learn more: http://amsterdamnews.com/news/2018/feb/22/nyul-champions-of-diversity/

The Economist – February 22 The Ramifications Of A New Type Of Gene Many genes, it transpires, do not encode proteins. Instead, they regulate which proteins are produced. These newly discovered genes are sources of small pieces of RNA, known as micro-RNAs. Response to stress is not the only thing in which micro-RNAs are implicated. They are also suspected of involvement in schizophrenia and bipolar disorder. To investigate this, Paul J. Kenny, PhD, professor and chair of neuroscience and director of the drug discovery institute at the Icahn School of Medicine at Mount Sinai, turned to mice. The root of Dr. Kenny’s suspicion was the discovery, post mortem, in the brains of patients who had been suffering from these conditions, of elevated levels of three micro-RNAs. He and his colleague Molly Heyer, a postdoctoral fellow in neuroscience at the Mount Sinai Health System, therefore looked at the role of these micro-RNAs in regulating brain cells called parvalbumin interneurons, which are thought to be involved in schizophrenia. What this means for the study of schizophrenia is unclear. It is possible that examination of the other two pertinent micro-RNAs may shed more light on the matter. More generally, though, Dr. Kenny’s work is a good example of the fact that there is more to genes than was once believed. - Paul J. Kenny, PhD, Professor, Chair, Neuroscience, Director, Drug Discovery Institute, Icahn School of Medicine at Mount Sinai - Molly Heyer, Postdoctoral Fellow, Neuroscience, Mount Sinai Health System Learn more: https://www.economist.com/news/science-and-technology/21737248-it-can-pass-acquired- characteristics-ramifications-new-type-gene

Multiple Sclerosis News Today – February 23 Pilot Study Is Testing Whether Mediterranean Diet Can Help MS Patients — Ana Pena New York researchers are doing a pilot study of whether a Mediterranean diet can reduce multiple sclerosis symptoms and improve patients’ quality of life. Ilana Katz Sand, MD, assistant professor of neurology at the Icahn School of Medicine at Mount Sinai and associate medical director of the Corinne Goldsmith Dickinson Center for Multiple Sclerosis, is leading the research. Diet can change the composition of gut bacteria. Some people with MS try to eat well and maintain their health. A poor diet can interfere with energy levels, bladder and bowel health, and possibly shift the immune system to a more or less inflammatory state. “We want to better understand the inflammatory process, the neurodegenerative process, and the effect that diet has on MS symptoms,” said Dr. Sand. “Our findings could be very important in understanding the onset of MS and how to treat it.” The diet is expected to generate changes in patients’ biological parameters, such as levels of lipids and carotenoids in blood, and salt in urine. Researchers are measuring these markers during the study. - Ilana Katz Sand, MD, Assistant Professor, Neurology, Icahn School of Medicine at Mount Sinai, Associate Medical Director, The Corinne Goldsmith Dickinson Center for Multiple Sclerosis Learn more: https://multiplesclerosisnewstoday.com/2018/02/23/pilot-multiple-sclerosis-study- mediterranean-die/

Medscape – February 22 Allergy Drug May Reduce Relapse In Neuromyelitis Optica — Nancy A. Melville The popular allergy medication cetirizine, known as Zyrtec, when added to standard therapy, shows the potential to reduce the rate of relapse of the neuromyelitis optica (NMO), in a small but important study. "We were pleased to find that cetirizine was safe and well-tolerated in our population of NMO patients," said senior author, Ilana Katz Sand, MD, assistant professor of neurology at the Icahn School of Medicine at Mount Sinai. "While the study's open-label design and small sample size preclude definitive conclusions, we did detect a signal that suggested cetirizine may be of benefit." The study should pave the way for more robust research into the role of cetirizine vs placebo in NMO treatment, she said. “A natural next step would be to do a larger, randomized trial of cetirizine as an add-on to standard NMO therapy.” - Ilana Katz Sand, MD, Assistant Professor, Neurology, Icahn School of Medicine at Mount Sinai, Associate Medical Director, The Corinne Goldsmith Dickinson Center for Multiple Sclerosis Learn more: https://www.medscape.com/viewarticle/893016

Psychology Today – February 22 Is Depression Really Four Illnesses? — Temma Ehrenfeld Recent brain scan analysis suggests four distinct kinds of depression, according to study results that appeared in Nature Medicine. Fine-tuning diagnosis could ultimately transform care. “We’ll see brain scan information help patients in three to five years,” said Helen Mayberg, MD, senior faculty of neurosurgery, neurology, psychiatry and neuroscience at the Icahn School of Medicine at Mount Sinai and director of the center for advanced circuit therapeutics at the Mount Sinai Health System. “We’re going to have precision psychotherapy the way we have precision cancer treatment.” Although an fMRI brain scan of someone with depression looks normal at first, over time brain imaging reveals that certain areas are becoming active together--indicating “functional connectivity.” - Helen Mayberg, MD, Senior Faculty, Neurosurgery, Neurology, Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, Director, The Center for Advanced Circuit Therapeutics, Mount Sinai Health System Learn more: https://www.psychologytoday.com/blog/open-gently/201802/is-depression-really-four- illnesses

Healio – February 22 Elotuzumab Plus Stem Cell Transplant Shows Promise For Multiple Myeloma— Alexandra Todak The addition of elotuzumab and autologous peripheral blood mononuclear cell reconstitution to autologous hematopoietic stem cell transplantation plus lenalidomide maintenance appeared effective with a manageable safety profile, according to results of a phase 1b open-label trial presented at BMT Tandem Meetings. “The autologous HSCT platform is a good setting for exploring immunotherapeutic therapies, because it is a platform in which there is minimal disease burden and immunogenic cell death,” said Keren Osman, MD, associate professor of medicine, hematology and medical oncology at the Icahn School of Medicine at Mount Sinai, during her presentation. She concluded that, “These results suggest elotuzumab and lenalidomide may support persistence or increases in clonal T-cell populations posttransplant.”She added that a phase two study is planned. - Keren Osman, MD, Associate Professor, Medicine, Hematology, Medical Oncology, Icahn School of Medicine at Mount Sinai Learn more: https://www.healio.com/hematology-oncology/myeloma/news/online/%7B7feae0e9-2c3f- 4873-b07d-f005c1560c7a%7D/elotuzumab-plus-stem-cell-transplant-shows-promise-for-multiple- myeloma Additional coverage: Hematology Times https://www.hematologytimes.com/section/myeloma/article/asct-regimen-deemed- safe-and-feasible-in-mm/

ABC News: Good Morning America – February 23 ‘Dancing With The Stars’ Pro Surprises Teen With Scoliosis Who Can Dance Again After Surgery — Catherine Thorbecke A championship ballroom dancer who was forced to give up her passion due to a medical condition that caused her spine to be disfigured is now able to dance again following a life-changing experimental surgery that re-aligned her spine. Despite being diagnosed with scoliosis, a disorder in which there is a sideways curve of the spine, the dancer thinks dancing is what she was meant to do. The dancer found Baron Lonner, MD, professor of orthopaedics, pediatrics and neurosurgery at the Icahn School of Medicine at Mount Sinai, who offered an experimental, and not FDA approved alternative treatment for scoliosis called tethering. In this procedure, Dr. Lonner attached a flexible cord onto screws placed in the vertebrae. When the cord is tightened, it compresses the screw to straighten the spine. “It preserves and maintains flexibility for the patient, as well as growth for those who are still growing,” Dr. Lonner said. He added that, “our hope is to develop this procedure so that we will have cords that last a lifetime.” - Baron Lonner, MD, Professor, Orthopaedics, Pediatrics, Neurosurgery, Icahn School of Medicine at Mount Sinai Learn more: http://abcnews.go.com/GMA/Culture/dancing-stars-pro-surprises-teen-scoliosis-dance- surgery/story?id=53273524

NY1 News – February 22 Some Pediatricians Now Include ‘Literacy Checkups’ In Their Exams — Lindsey Christ Pediatricians already ask parents about how their children have been eating and sleeping, but some are now asking about their reading habits as well. When Leora Mogilner, MD, assistant professor of pediatrics at the Icahn School of Medicine at Mount Sinai sees patients for checkups, she brings her stethoscope and a picture book. The book is a critical part of the exam. While pediatricians check on the child’s physical health, they are also supposed to talk with parents about reading. Research shows reading to children boosts brain development and helps with emotional bonding. “The American Academy of Pediatrics issued guidelines recommending that literacy promotion be part of regular pediatric primary care,” said Dr. Mogilner. - Leora Mogilner, MD, Assistant Professor, Pediatrics, Icahn School of Medicine at Mount Sinai Learn more: http://www.ny1.com/nyc/all-boroughs/education/2018/02/22/some-pediatricians-now- include--literacy-checkups--in-their-exams

WebMD – February 22 Exercising Yourself To Death: The Rare Risk Of Rhabdo — Jennifer Clopton Rhabdomyolysis is a syndrome involving muscle breakdown and damage. When muscles are injured, they release their contents, including a muscle enzyme, into the bloodstream. The enzyme can harm the kidneys and can cause kidney failure in up to 40 percent of cases. It also can harm the kidneys’ ability to remove urine and other waste. Patients generally recover when they get prompt treatment, but the condition can lead to death in rare cases. Alexis Colvin, MD, associate professor of sports medicine and orthopaedics at the Icahn School of Medicine at Mount Sinai, said she’s also heard of cases connected to marathons and ultramarathons. “There is definitely more awareness of it with the popularity of people looking for different ways of challenging themselves,” she added. “It’s about the trend in how you are feeling. In most typical recoveries, people tend to start to move in the right direction, but with rhabdo, that isn’t the case. Untreated, it will most likely get worse.” - Alexis Colvin, MD, Associate Professor, Sports Medicine, Orthopaedics, Icahn School of Medicine at Mount Sinai, Chief Medical Officer, United States Tennis Association Learn more: https://www.webmd.com/fitness-exercise/news/20180222/exercising-yourself-to-death-the- risk-of-rhabdo

Health Magazine – February 22 How To Lose Weight On A Part-Time Diet — Jacqueline Andriakos Part-time dieting is an umbrella term for eating styles that let you be flexible with the hours, days, even weeks that you cut calories. Recent research is starting to uncover how different methods may make it easier to shed pounds and improve health. Before you try this on-off strategy, remember this: You can’t eat what you want during your no-dieting period. “Consuming 5,000 calories just because it’s your ‘free’ week is not efficient. You still want to think about filling your body with whole foods,” said Jennifer Cholewka, RD, CNSC, senior dietician at The Mount Sinai Hospital. A few studies have linked the 5:2 diet – which calls for eating normally five days of the week and only 25 percent of your typical calorie intake for two days of your choice – to weight loss and lower your insulin levels. “If I were to try any part-time diet, the 5:2 plan would be my pick,” said Cholewka. - Jennifer Cholewka, RD, CNSC, Senior Dietician, The Mount Sinai Hospital Learn more: http://www.health.com/weight-loss/part-time-diets Additional coverage: Southern Living https://www.southernliving.com/syndication/part-time-diets

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