From: ITNDaily Subject: Mount Sinai In The News - February 5, 2018 Date: Monday, February 05, 2018 3:03:34 PM Attachments: ATT00001.txt In the News February 5, 2018 Genetic Engineering & Biotechnology News – February 5 Grape-Derived Compounds May Help To Prevent Depression Scientists have identified two grape-derived compounds that can effectively help to treat and protect against stress-induced depression in mice, and which could represent promising new candidates for treating depression in humans. The compounds, dihydrocaffeic acid (DHCA) and malvidin-3'-O- glucoside (Mal-gluc), trigger epigenetic changes in genes that affect inflammation and synaptic plasticity, mechanisms that aren’t addressed by current antidepressants. “Our approach to use a combination treatment of DHCA and Mal-gluc to simultaneously inhibit peripheral inflammation and modulate synaptic plasticity in the brain works synergistically to optimize resilience against chronic stress-induced depression-like phenotypes,” said lead researcher, Giulio Maria Pasinetti, PhD, MD, Saunders professor of neurology and program director of the Center for Molecular Integrative Neuroresilience at the Icahn School of Medicine at Mount Sinai. “The discovery of these new, natural grape-derived polyphenol compounds targeting cellular and molecular pathways associated with inflammation may provide an effective way to treat a subset of people with depression and anxiety, a condition that affects so many people." - Giulio Maria Pasinetti, PhD, MD, Saunders Professor, Neurology, Program Director, Center for Molecular Integrative Neuroresilience, Icahn School of Medicine at Mount Sinai Learn more: https://www.genengnews.com/gen-news-highlights/grape-derived-compounds-may-help- to-prevent-depression/81255456 Additional coverage: Healthcare Journal https://journalhealthcare.com/72/machine-learning-natural-language-processing- used-to-generate-clinical-labels-of-medical-scans/ Doctor NDTV https://doctor.ndtv.com/living-healthy/grape-derived-compounds-may-help-treat- depression-says-study-1808631 India Today https://www.indiatoday.in/pti-feed/story/grape-derived-compounds-may-help-treat- depression-1161684-2018-02-04 The Inquisitr https://www.inquisitr.com/4771101/grape-derived-compounds-could-help-treat-depression- a-new-study-reveals/ Laboratory Equipment https://www.laboratoryequipment.com/news/2018/02/grape-derived-compounds- may-promote-resilience-against-depression Medical News Today https://www.medicalnewstoday.com/articles/320830.php Politico New York – February 5 Off Label — Dan Goldberg Zyrtec, the allergy medicine, may reduce relapses of demyelinating inflammatory disease neuromyelitis optica, according to Dr. Ilana Katz Sand, assistant professor of Neurology at the Icahn School of Medicine. - Ilana Katz Sand, MD, Assistant Professor, Neurology, Icahn School of Medicine at Mount Sinai Learn more: https://www.politicopro.com/states/new-york/newsletters/politico-new-york-health- care/2018/02/05/h-h-to-announce-new-care-management-program-030285 American Council on Science and Health – February 5 Machines Learn To Mimic Physician’s Thought – Kicking It Old School — Chuck Dinerstein The advance of machines into medical diagnostics continues. Machines learn based upon a large dataset of images and linked conclusion - information on whether cancer or diabetic retinopathy or some other condition is present. It should therefore come as no surprise that having not provided information on how humans reach conclusions the machines found their own path, hidden from our understanding. This opacity and our inability to have faith in conclusions we cannot understand represents a profound stumbling block to adoption of these tools. The authors of a study in Radiology are taking a new, well really old, approach to explanation. Using radiology reports to detect expert’s thinking is a beautiful insight. By abstracting thousands of reports, machines can be given a crowd-sourced structured description of images, descriptions that could form the basis for explanations we can more readily comprehend. But first computers need to learn radiologist’s structured approach, the subject of this study. - Eric Oermann, MD, Instructor, Neurosurgery, Icahn School of Medicine at Mount Sinai - John Zech, Medical Student, Icahn School of Medicine at Mount Sinai - Joshua Bederson, MD, Professor, System Chair, Neurosurgery, Mount Sinai Health System, Clinical Director, Neurosurgery Simulation Core Learn more: https://www.acsh.org/news/2018/02/05/machines-learn-mimic-physicians-thought-kicking- it-old-school-12521 Radiology Business – January 30 Otolaryngology Training Programs Cover Radiology Services, But Lack Structure — Subrata Thakar Though most otolaryngology residency programs have a radiology curriculum within their residency program, a thorough review of radiology education requirements from the Accreditation Council for Graduate Medical Education (ACGME) is needed, according to a new study published in JAMA Otolaryngology – Head & Neck Surgery. “Otolaryngologists rely on various head and neck imaging modalities on a daily basis,” wrote authors Kirkland N. Lozada, MD, resident physician at the New York Eye and Ear Infirmary of Mount Sinai, and Joseph M. Bernstein, MD, associate professor of otolaryngology at the Icahn School of Medicine at Mount Sinai. “Experience with ordering and interpreting radiologic studies is an important competency for all graduating residents of otolaryngology programs. However, little is known how residency programs structure training in head and neck imaging throughout the five years.” They added that given the considerable variability encountered in radiology education, “we believe standardized program requirements will improve education across all programs, enhance the level of patient care, and further the disciplinary teamwork of otolaryngologists and radiologists.” - Joseph M. Bernstein, MD, Associate Professor, Otolaryngology, Icahn School of Medicine at Mount Sinai Kirkland Lozada, MD, Resident Physician of Otolaryngology, New York Eye and Ear Infirmary of Mount Sinai Learn more: http://www.radiologybusiness.com/topics/practice-management/quality/otolaryngology- training-programs-cover-radiology-services-lack-structure-and-consistency CBS News – February 5 More U.S. Teens Identify As Transgender Far more U.S. teens than previously thought are transgender or identify themselves using other nontraditional gender terms, with many rejecting the idea that girl and boy are the only options, research suggests. "I tend to use the analogy of sexual orientation," said John Steever, MD, assistant professor of pediatrics at the Icahn School of Medicine at Mount Sinai and director of special programs at the Mount Sinai Adolescent Health Center, explained in “Gender: The Space Between,” emphasizing that point that a binary definition is not sufficient. "Most people are familiar with being either straight or gay. And most people are familiar with the concept of being bisexual, attracted to both. So if you apply that construct to gender, then that opens up the idea that there is more than just boys, girls, men, women. There can be people who live in the spaces between that. And I'll often point out examples from pop culture — people like Grace Jones or David Bowie — people whose gender presentation is a little ambiguous." - John Steever, MD, Assistant Professor, Pediatrics, Icahn School of Medicine at Mount Sinai, Director, Special Programs, Mount Sinai Adolescent Health Center Learn more: https://www.cbsnews.com/news/more-u-s-teens-identify-as-transgender/ LongIsland.com – February 1 Governor Cuomo Announces $37.7 Million Awarded To Improve Access To Breast Cancer Screening Across New York State Governor Andrew M. Cuomo announced $37.7 million in funding as part of the “Get Screened, No Excuses” initiative to improve access to breast cancer screening for New Yorkers. Funds are being used to support peer educators in community settings, make patient navigators available to help women as they undergo screening and other necessary follow-up care, and operate mobile mammography vans in underserved neighborhoods to bring health services to New Yorkers. These statewide programs are successfully reducing barriers to breast cancer screening for women, including those who lack access to preventative health care because they are economically disadvantaged, live in underserved inner-cities, or live in remote rural areas. The Mount Sinai Hospital is one of the awardee’s that will receive funding for the mobile mammography initiative. - The Mount Sinai Hospital Learn more: https://www.longisland.com/news/02-01-18/governor-cuomo-announces-377-million- awarded-to-improve-access-to-breast-cancer-screening-across-new-york-state.html Crain’s Health Pulse – February 5 State Health Department Helps Usher Behavioral-Health Providers Into Value-Based Era — Jonathan LaMantia As the state moves more of its Medicaid spending into payments that reward high-quality providers, a new program aims to accelerate progress on the behavioral-health side. The state is investing $60 million over the next three years through the Behavioral Health Value Based Payment Readiness program to get more providers up to speed. Some agencies have already begun experimenting with value-based payments. Institute for Community Living is participating in a pilot with Mount Sinai Health Partners and Healthfirst that reimburses providers for care delivered to people with Health and Recovery Plans, said David Woodlock, ICL's president