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R.T.R. Clinical Cases Studies Package

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R.T.R. Clinical Cases Studies Package Cover test.qxp_Mise en page 1 12/09/2018 11:14 Page1 CaSepstodeont Studies September 2018 ion SPECIAL ECDolIleTct ION R.T.R. Full resorption... strong new bone formation Case Studies Collection_RTR_Synthesis.qxp_Mise en page 1 31/08/2018 10:56 Page2 Case Studies Collection_RTR_Synthesis.qxp_Mise en page 1 31/08/2018 10:56 Page3 Content Bone Augmentation Biomaterials for bone regeneration in oral surgery: A multicenter study to evaluate the clinical application of “R.T.R.” ............................................................................................................... 04 P. Brunamonti Binello, G. Galvagna, M. Galli, M. Labanca Use of ß-tricalcium phosphate for bone regeneration in oral surgery ......................................................... 12 G. Galvagna, P. Brunamonti Binello, M. Galli, M. Labanca ß-tricalcium phosphate used with onlay graft for horizontal bone augmentation yielded preferable result: a case report ................................................................................................. 22 Yaqian Chen, Qingqing Wu, Yi Man Post-extraction sockets Bone regeneration with ß-tricalcium phosphate (R.T.R.) in post-extraction sockets .................. 27 O. H. Arribasplata Loconi Use of R.T.R. and PRF as filling material in post extraction sockets ......................................................... 36 P. González, O. González, C. Zenteno, J. Urrizola Alveolar Ridge Preservation Alveolar Ridge Preservation With Alloplastic Material ........................................................................................... 40 Ana I. Coello Gómez, Selene P. Navarro Suárez, Daniel Torres Lagares, Jose Luis Gutiérrez Perez Clinical case of alveolar ridge preservation with alloplastic material: Results at 6 months ................................................................................................................................ 46 Dr. S. P. Navarro Suárez, Dr. D. Torres Lagares, Dr. J. L. Gutiérrez Pérez Alveolar preservation with R.T.R ................................................................................................................................................. 50 Dr Gabriela Vilar Pineda Periodontal defects R.T.R. and aggressive periodontitis ............................................................................................................................................. 59 D. Bouziane, K. L. Makrelouf, M. Bouziane Alloplastic Grafts - Beta-tricalcium phosphate ................................................................................................................. 67 Mario Ernesto García-Briseño Periodontal intraoseous defects and post-extraction compromised socket. Treatment with Beta Tricalcium Phosphate ..................................................................................................... 74 Dr. Mario Ernesto García Briseño Sinus Lift Sinus Floor Augmentation with ß-Tricalcium Phosphate (R.T.R. Septodont) ................................... 79 Mario Ernesto García-Briseño 3 Case Studies Collection_RTR_Synthesis.qxp_Mise en page 1 31/08/2018 10:56 Page4 Biomaterials f or bone regeneration in oral surgery: A multicenter study to evaluate the clinical application of “R.T.R.” (ß-Tricalcium Phosphate) Paolo Brunamonti Binello : Consultant Professor, University of Genoa Giuseppe Galvagna : Private practice, Catania, Italy Massimo Galli : Private practice, Pistoia, Italy Mauro Labanca : Consultant Professor in Oral Surgery and Anatomy, Milan, Italy In Literature there isn’t any conflicting data about the clinical results obtained in Oral Surgery for bone regeneration using Biomaterials of either animal or synthetic origin. (1) What is the most important, however, is the creation of a microenvironment suitable for the proliferation and differentiation of hard tissues, such as to successfully promote the regeneration of new bone at the implant-prosthetic purposes. (1-2) For this reason, therefore, the Authors always prefer the use of synthetic materials with reduced risk of inflammation and complete absence of potential cross infections. (1) The Goal of this study is, therefore, to illustrate - through a case series - short term results of a multicenter research on bone regeneration in Oral Surgery by using an heterologous filling material that consists of ß-Tricalcium Phosphate, called R.T.R. Introduction International Literature about bone regeneration the surgical technique), turned out to be predic - in implant dentistry describes many different table if done correctly. (3) available surgical techniques and the following The Literature data, then, show how - osteogenic are the principal: distractions aside - the use of a biomaterial • Guided Bone Regeneration (G.B.R.) (regardless of its origin, whether animal or • Bone Grafting synthetic) is helpful if not indispensable to the • Osteogenic Distractions attainment of an adequate clinical outcome. (4) Each of the above mentioned methods, while Finally, the use of semi-permeable barriers - presenting different and precise application whether or not absorbable membranes - rather limits (mostly related to the type of defect and than metal grids, in order to maintain a suitable 4 Case Studies Collection_RTR_Synthesis.qxp_Mise en page 1 31/08/2018 10:56 Page5 space, has proved indispensable in G.B.R., while genesis, understood as a budding center of it is still extremely discussed in other regenerative deputies to the new bone genesis: techniques. (5) - Osteoinduction: stimulation of the differentiation In fact, when we speak about Biomaterials in of mesenchymal cells in preosteoblasts. Regenerative Oral Surgery it is appropriate to - Osteoconduction: biological scaffold as a support make a distinction between the following to new cells in the differentiation process. elements: - Semi-permeable membranes : they allow the It is deduced that the new bone tissue formation stabilization of cloth and the selection of cell occurs if the following organic conditions exist: lines that will colonize the bone defect (space - Availability of mesenchymal cells capable of maintainer = maintenance of biological space). differentiating following the osteoinductive input - Filling material : Support the membrane and - Presence of osteoinductive input ("Osteoin - act as a "scaffold" for the migration, growth ductive Boost"), which initiates the differentiation and differentiation of pre-osteoblasts into of mesenchymal preosteoblasts in osteoblasts osteoblasts. - Existence of an osteoconductive environment To contribute to the regeneration process, here that promotes the colonization and proliferation are the following basic mechanisms of Osteo - of graft. R.T.R. (ß-tricalcium phosphate) Except for autologous bone, on the fundamental into the site of regeneration: this creates an concepts of Osteogenesis, remains today still ideal ionic concentration with an alkaline pH, open the debate as to which type of currently which stimulates the activation of alkaline phos - available bone grafting material is the best. (6) phatase enzyme, which is essential to the ossification process. (6-8) Given that, the Authors have carried out a multi - center research about clinical application of a Then, all resources of this study and the attention synthetic filler (already known for years on the of the authors are focused on the use of ß-Trical - market) based on ß-Tricalcium Phosphate for cium Phosphate called “R.T.R.” basically because bone regenerative purposes, called “R.T.R.” this synthetic biom aterial would possess - as a (Resorbable Tissue Replacement). (6) prerequisite - all the features that a generic The Ca 3(PO 4)2 powder (treated with naphthalene filling material should have -with the exception and subsequently compacted by sintering) form of Osteinduction. (6-7-8) the ß-tricalcium phosphate, with macropores of These characteristics may be summarized as a diameter between 100 and 300 microns ideal, follows: that is, for the Osteoconduction. (6) - High biocompatibility and minimum autoimmune This heterologous biomaterial, once placed, is response completely absorbed in 6 or 9 months, and - Bio-inert (absence of local inflammatory reac - replaced by new bone. (6-7) tion) Recent studies on large crestal defects show a - Ideal time of resorption for the type of bone significant increase in the regeneration with defect ß-Tricalcium Phosphate already after 2 weeks - Total reabsorption compared to the other control sites, thereby - Excellent osteoconductivity proving the effectiveness of this filling material. (7) - Good packaging During resorption, in addition, ß-Tricalcium Phos - - High handling during surgery phate provides with Ca ions and phosphate - Absolutely no risk of cross-infection transmission 5 Case Studies Collection_RTR_Synthesis.qxp_Mise en page 1 31/08/2018 10:56 Page6 In particular, since “R.T.R.” is completely resor - implant-prosthetic rehabilitation, in contrast with bable over a period of time, reasonably useful many other filling materials that do not resorb for important bone defects resolution, the authors completely - and allow only a repair instead of a think “R.T.R.” is particularly appropriate for all healing of the bone defect. (8-9) regenerations conducted for the purpose of Materials and methods This multicenter Study provides for the regene - Regarding the type of defect, it is deliberately ration of bone tissue with ß-tricalcium phosphate excluded to standardize the same, in terms of ”R.T.R.” in patients with a residual bone defect morphology and etiopathogenesis,
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