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Genome Technology Contents | Zoom in | Zoom out For navigation instructions please click here Search Issue | Next Page This Month in Genome Technology SPECIAL ISSUE Genome Technology GT Celebrates the Rising Young Stars of Science 30 promising researchers – recommended by today’s established PIs – are profiled in this exclusive year-end issue. We highlight their work in these categories and more: Sequencing Synthetic biology RNAi Gene expression Computational biology Structural variation Proteomics Translational research Genome Technology Online Log on now at www.genome-technology.com Recent results from GT Polls Explore all of our exclusive new resources for molecular biologists: Would you speak at a conference that The Daily Scan: Our editors’ daily picks of what’s worth reading didn’t pay your registration fee? on the Web. Nope, I’d boycott on principle. They should The Forum: Where scientists can inquire and comment on at least let you into the conference. 66% research, tools, and other topics. I’d grumble about it, but ultimately accept. Podcasts: Hear the full comments – in their own voices – of It’s worth the extra line on my CV. 16% researchers interviewed in the Genome Technology Magazine. Sure, why not? 18% Polls: Make your opinion known on topics from the sublime to the ridiculous. Archive: Magazine subscribers can read every word of every article we have ever published. Contents | Zoom in | Zoom out For navigation instructions please click here Search Issue | Next Page A Genome Technology Previous Page | Contents | Zoom in | Zoom out | Front Cover | Search Issue | Next Page BEF MaGS __________________________________________ A Genome Technology Previous Page | Contents | Zoom in | Zoom out | Front Cover | Search Issue | Next Page BEF MaGS A Genome Technology Previous Page | Contents | Zoom in | Zoom out | Front Cover | Search Issue | Next Page BEF MaGS 9FELJ1 NEXT-GEN SEQUENCE ANALYSIS AND AGBIO TECH GUIDES ;<:<D9<I)''/&A8EL8IP)''0 THIRD ANNUAL Tomorrow’s PIs Genome Technology’s special year-end issue profiles rising young investigators A Genome Technology Previous Page | Contents | Zoom in | Zoom out | Front Cover | Search Issue | Next Page BEF MaGS A Genome Technology Previous Page | Contents | Zoom in | Zoom out | Front Cover | Search Issue | Next Page BEF MaGS ______________________________ __________________________ A Genome Technology Previous Page | Contents | Zoom in | Zoom out | Front Cover | Search Issue | Next Page BEF MaGS A Genome Technology Previous Page | Contents | Zoom in | Zoom out | Front Cover | Search Issue | Next Page BEF MaGS DECEMBER 2008/JANUARY 2009 Contents 28 CARL KINGSFORD A computer Tomorrow’s PIs scientist takes on transcription Resources SEQUENCING 29 JAMES TAYLOR 5 PRIMER Researching to help researchers Starting out, already stars 9 JAY SHENDURE Functional testing with next-gen technology 30 WOLFGANG HUBER 7 DEMOGRAPHICS Pushing statistics to the limit In numbers 10 LI DING The genomic basis of cancer PROTEOMICS 48 CAREERS Steps to start your career 11 ROBERT RIEHN Stretching 31 XUDONG YAO From signal and sequencing DNA transduction to cystic fibrosis 51 FUNDING Grant opportunities SYNTHETIC BIOLOGY 32 GISELLE KNUDSEN From detection to drugs 53 LOOKING AHEAD 12 TIM LU Letting the bedside Next-gen tomorrow’s PIs inform the bench 33 WEI-JUN QIAN Step by step, a better mass spec 54 CLASS OF 2007 STRUCTURAL BIOLOGY A year later POPULATION GENETICS 15 DAVID MATHEWS Looking for 57 RECOMMENDERS Thanks to today’s PIs secondary structure 34 SHAMIL SUNYAEV A better approach to interpretation 16 BOJAN ZAGROVIC 58 BLUNT END Finding order in disorder 35 RAUL RABADAN Elucidating evolution, virus by virus 17 OLIVER RANDO Opening the ‘black box’ of chromatin COMPARATIVE GENOMICS RNA INTERFERENCE 37 RACHAEL THOMAS Cancer in dogs, cats, and people 19 JULIUS BRENNECKE Parsing nature’s elegant solutions TRANSLATIONAL 20 KEVIN MORRIS RESEARCH “In the future, Another mode of gene silencing 39 CAREY LUMENG Investigating experimental and the perils of obesity STRUCTURAL VARIATION computational 40 BRIDGET WAGNER Large-scale 21 GREG COOPER screens to study diabetes biology are only going A compelling look at variation 41 CHARLES SCHROEDER to become more GENE EXPRESSION ‘Cells in, disease out’ intertwined and even 23 ADRIANA BRISCOE 42 GAD GETZ The physicist who inseparable. What I It’s all in the eyes tackled cancer hope to see is a culture 24 UWE OHLER Imaging gene regulation REGULATORY ELEMENTS that ... [understands] 45 LEN PENNACCHIO Finding 25 MARIAN WALHOUT A fresh look if it isn’t transparent function in dark matter at differential expression and reproducible, it 46 ZHAOLEI ZHANG Where COMPUTATIONAL BIOLOGY collaborations are king isn’t science.” 27 PAUL FLICEK 47 LAURA ELNITSKI In the informatics trenches The functional perspective James Taylor, page 29 DECEMBER 2008/JANUARY 2009 GENOME TECHNOLOGY 3 A Genome Technology Previous Page | Contents | Zoom in | Zoom out | Front Cover | Search Issue | Next Page BEF MaGS A Genome Technology Previous Page | Contents | Zoom in | Zoom out | Front Cover | Search Issue | Next Page BEF MaGS _____________ A Genome Technology Previous Page | Contents | Zoom in | Zoom out | Front Cover | Search Issue | Next Page BEF MaGS A Genome Technology Previous Page | Contents | Zoom in | Zoom out | Front Cover | Search Issue | Next Page BEF MaGS FROM THE EDITOR Primer ISSUE NO. 87 125 Maiden Lane, Second Floor New York, NY 10038 Starting Out, Already Stars Tel +1 212 269 4747 Fax +1 212 269 3686 GENOME-TECHNOLOGY.COM__________________ ack when we came up with the idea for Tomorrow’s PIs EDITORIAL DIRECTOR — a special issue designed to introduce our readers to a Meredith W. Salisbury new generation of promising scientists still early in their [email protected] SENIOR EDITOR careers — we really had no clue how the whole thing Ciara Curtin [email protected] would pan out. Now, as we’re getting ready to send the SENIOR WRITERS Bthird annual Tomorrow’s PIs edition to the printer, we can’t imagine Matthew Dublin [email protected] Jeanene Swanson [email protected] what we’d do without it. People we’ve profiled in the past have gone ART DIRECTOR Therese Shechter ___________info@trixiefilms.com on to do great things in science, and no doubt that will continue. GENOMEWEB DAILY NEWS This magazine began in the summer, when we started consulting Bernadette Toner, Editorial Director, News experts in the systems biology community to get recommenda- [email protected] tions for scientists who will soon be taking the world by storm. We Ed Winnick, Managing Editor [email protected] looked for nominees who are no more than five years or so past their Matt Jones, Reporter postdoc and then selected a group with a diverse range of scientific [email protected] interests, backgrounds, and affiliations. After many, many inter- Andrea Anderson, Reporter [email protected] views (and more planning meetings than the Genome Technology staff GENOMEWEB NEWSLETTERS would care to remember), we emerged Kirell Lakhman, News Editor [email protected] with the final 30 people who are profiled Justin Petrone, BioArray News Editor in this issue. As always, we had far more [email protected] recommendations than we could actually Vivien Marx, BioInform Editor [email protected]_____________ print, so we’ll have mini-profiles of many Alex Philippidis, BioRegion News Editor more young investigators throughout the [email protected] year at www.genome-technology.com. Ben Butkus, Biotech Transfer Week Editor [email protected] We’re so grateful to the outstanding Charlotte LoBuono, Cell-Based Assay News Editor [email protected] cast of scientists who contacted us with Julia Karow, In Sequence Editor nominations — without them, this issue [email protected] would not be possible. Turna Ray, Pharmacogenomics Reporter Editor [email protected]____________ One thing we noticed this year was a particular challenge in as- Tony Fong, ProteoMonitor Editor signing these up-and-coming scientists to technology categories. The _____________ [email protected] research they’re engaged in is becoming more integrative, bringing Doug Macron, RNAi News Editor [email protected]______________ together lots of platforms and concepts from different disciplines. CHAIRMAN AND PUBLISHER You’ll also see that next-gen sequencing is really shaking things up; Dennis P.Waters, PhD [email protected] many of the scientists say that advances in that technology have ADVERTISING/SALES thoroughly changed the kinds of experiments they’re able to do. Judy Block, Associate Publisher The advertisers in this issue have made it possible for us to give [email protected] +1 212 651 5629 a travel stipend to each of the scientists profiled here, so we also Allan Nixon, Director of Business Development [email protected] +1 212 651 5623 thank them very much for their generosity and support of these David Samuels, Subscriptions and early-career researchers. Site License Manager [email protected]_______________ OPERATIONS AND FINANCE Greg Anderson, Director [email protected] Meredith W. Salisbury, Editor Philip Borowiecki, Associate [email protected] What do you think of Genome Technology? Let me know how we’re doing by
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