HHMI Constellation Studios for Science Education November 13-15, 2015 | HHMI Headquarters | Chevy Chase, MD

Big Data, MOOCs, and Quantitative Education for Biologists

Co-Chairs Pavel Pevzner, University of California- San Diego Sarah Elgin, Washington University Studio Objectives

 Discuss existing challenges in education with experts in and quantitative biology education,  Evaluate best practices in teaching quantitative and computational biology, and  Collaborate with scientist educators to develop instructional modules to support a biology curriculum that includes quantitative approaches.

Friday | November 13 4:00 pm Arrival Registration Desk 5:30 – 6:00 pm Reception Great Hall 6:00 – 7:00 pm Dinner Dining Room 7:00 – 7:15 pm Welcome K202 David Asai, HHMI Cynthia Bauerle, HHMI Pavel Pevzner, University of California-San Diego Sarah Elgin, Washington University Alex Hartemink, Duke University 7:15 – 8:00 pm How to Maximize Interaction and Feedback During the Studio K202 Cynthia Bauerle and Sarah Simmons, HHMI 8:00 – 9:00 pm Keynote Presentation K202 "Computing + Biology = Discovery" Speakers: Ran Libeskind-Hadas, Harvey Mudd College Eliot Bush, Harvey Mudd College 9:00 – 11:00 pm Social The Pilot

Saturday | November 14 7:30 – 8:15 am Breakfast Dining Room 8:30 – 10:00 am Lecture session 1 K202 Moderator: Pavel Pevzner

834a-854a “How is body fat regulated?” Laurie Heyer, Davidson College 856a-916a “How can we find mutations that cause cancer?” Ben Raphael, Brown University “How does a tumor evolve over time?” 918a-938a Russell Schwartz, Carnegie Mellon University “How fast do ribosomes move?” 940a-1000a Carl Kingsford, Carnegie Mellon University 10:05 – 10:55 am Breakout working groups Rooms: S221, (coffee available in each room) N238, N241, N140 1. “How is body fat regulated?” (S221) 2. “How can we find mutations that cause cancer?” (N238) 3. “How does a tumor evolve over time?” (N241) 4. “How fast do ribosomes move?” (N140) 11:00 am – 12:30 pm Lecture session 2 K202 Moderator: Sally Elgin

1104a-1124a “How neurons do integrals” Mark Goldman, University of California-Davis 1126a-1146a “A hitchhiker’s guide to coevolution” Ran Libeskind-Hadas, Harvey Mudd College 1148p-1208p “Predicting of HIV drug resistance” Christopher Lee, University of California-Los Angeles

HHMI Constellation Studios for Science Education November 13-15, 2015 | HHMI Headquarters | Chevy Chase, MD

Saturday | November 14 (Cont.) 12:30 - 1:30 pm Lunch Dining Room 1:40 - 2:30 pm Breakout working groups Rooms: S221, (coffee available in each room) N238, N241

1. “How neurons do integrals” (S221) 2. “A hitchhiker’s guide to coevolution” (N238) 3. “Predicting evolution of HIV drug resistance” (N241) 2:35 – 4:05 pm Lecture session 3 K202 Moderator: Phillip Compeau

239p-259p “To be or not to be: male, female or both?” Véronique Delesalle, Gettysburg College 301p-321p “How does principal component analysis work with biological data?” Claudia Neuhauser, University of Minnesota 323p-343p “Designing vaccines to target viruses” Steven Skiena, SUNY Stonybrook

“Using divide-and-conquer to construct the tree of life” 345p-405p , University of Illinois Urbana-Champaign 4:10 - 5:00 pm Breakout working groups Rooms: S221, (coffee available in each room) N238, N241, N140 1. “To be or not to be: male, female or both?” (S221) 2. “How does principal component analysis work with biological data?” (N238) 3. “Designing vaccines to target viruses” (N241) 4. “Using divide-and-conquer to construct the tree of life” (N140) 5:05 – 5:30 pm Group Photo Atrium 5:35 – 6:30 pm Break/Reception Great Hall 6:30 – 7:25 pm Dinner Dining Hall 7:30 – 8:30 pm Brainstorming Breakout session D115, D116, Discussion 1: Identifying other resources to support quantitative education (D115) North & South Discussion 2: Defining quantitative learning outcomes for undergraduate biology students (D116) Lounges Discussion 3: Adapting and implementing quantitative education resources (North Lounge) Discussion 4: TBA, South Lounge D124 & D125 8:30 – 9:30 pm Full Group Report Out and Discussion Moderator, Alex Hartemink, Duke University 8:30 – 10:30 pm Re-recording Session (6 slots available for speakers from Session 1/2/3) K202 9:30 – 11:00 pm Social The Pilot

Sunday | November 15 7:30 – 8:15 am Breakfast Dining Room 8:30 – 10:00 am Lecture session 4 K202 Moderator: Alexander Hartemink

834a-854a “Compressive genomics in the next-gen world” , Massachusetts Institute of Technology 856a-916a “Searching for a sequence needle in a genome haystack” , University of California-Los Angeles 918a-938a “How to fit 6 billion DNA nucleotides in a 10 micron nucleus” Bill Noble, Washington University

“How genome assembly tracked the 2001 anthrax attacks to their source” 940a-1000a , 10:05 – 10:55 am Breakout working groups Rooms: S221, (coffee available in each room) N238, N241, N140 1. “Compressive Genomics : Scaling faster than light” (S221) 2. “Searching for a sequence needle in a genome haystack” (N238) 3. “How to fit 6 billion DNA nucleotides in a 10 micron nucleus” (N241) 4. “How genome assembly tracked the 2001 anthrax attacks to their source” (N140) 11:00 am – 11:50 am Closing Discussion K202 Pavel Pevzner, University of California-San Diego Sarah Elgin, Washington University Alex Hartemink, Duke University 12:00 – 1:00 pm Lunch Dining Hall 1:00 – 2:30 pm Re-recording Session (6 slots available for speakers from Session 3/4 ) K202