Anti-VAV3 (Aa 567-578) Polyclonal Antibody (DPABH-12442) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-VAV3 (aa 567-578) polyclonal antibody (DPABH-12442) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitement by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.

Immunogen Synthetic peptide: CSGEQGTLKLPEK, corresponding to internal sequence amino acids 567-578 of Human VAV3

Isotype IgG

Source/Host Goat

Species Reactivity Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Applications WB, IHC-P

Format Liquid

Size 50 μg

Buffer pH: 7.40; Constituents: 0.5% BSA, Tris buffered saline

Preservative 0.02% Sodium Azide

Storage Store at 4°C or at -20°C for long term storage.

GENE INFORMATION

Gene Name VAV3 vav 3 guanine nucleotide exchange factor [ Homo sapiens ]

Official Symbol VAV3

Synonyms VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; guanine nucleotide exchange factor VAV3; VAV-3; FLJ40431;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Protein Refseq NP_001073343

UniProt ID Q9UKW4

Chromosome Location 1p13.3

Pathway B cell receptor signaling pathway; Cell death signalling via NRAGE, NRIF and NADE; Chemokine signaling pathway; Coregulation of Androgen receptor activity; EGFR1 Signaling Pathway;

Function GTPase activator activity; Rac guanyl-nucleotide exchange factor activity; SH3/SH2 adaptor activity; epidermal growth factor receptor binding; guanyl-nucleotide exchange factor activity; metal ion binding; protein binding

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]