Anti-VAV3 (aa 567-578) polyclonal antibody (DPABH-12442) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitement by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Immunogen Synthetic peptide: CSGEQGTLKLPEK, corresponding to internal sequence amino acids 567-578 of Human VAV3 Isotype IgG Source/Host Goat Species Reactivity Human Purification Immunogen affinity purified Conjugate Unconjugated Applications WB, IHC-P Format Liquid Size 50 μg Buffer pH: 7.40; Constituents: 0.5% BSA, Tris buffered saline Preservative 0.02% Sodium Azide Storage Store at 4°C or at -20°C for long term storage. GENE INFORMATION Gene Name VAV3 vav 3 guanine nucleotide exchange factor [ Homo sapiens ] Official Symbol VAV3 Synonyms VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; guanine nucleotide exchange factor VAV3; VAV-3; FLJ40431; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Entrez Gene ID 10451 Protein Refseq NP_001073343 UniProt ID Q9UKW4 Chromosome Location 1p13.3 Pathway B cell receptor signaling pathway; Cell death signalling via NRAGE, NRIF and NADE; Chemokine signaling pathway; Coregulation of Androgen receptor activity; EGFR1 Signaling Pathway; Function GTPase activator activity; Rac guanyl-nucleotide exchange factor activity; SH3/SH2 adaptor activity; epidermal growth factor receptor binding; guanyl-nucleotide exchange factor activity; metal ion binding; protein binding 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.