University of Cape Town
RESEARCH REPORT
2000
Faculty of Health Sciences
This report can also be found on UCT’s webpage: http://www.uct.ac.za
Editor: Ms M. Ward
CONTENTS
FACULTY OF HEALTH SCIENCES
Introduction 1
Department of Anaesthesia 8
Department of Anatomical Pathology 11
Department of Cardiothoracic Surgery 17
Department of Chemical Pathology 23
Department of Dermatology 28
Department of Forensic Medicine and Toxicology 32
Department of Haematology 35
Department of Human Biology 38
Department of Human Genetics 44
Department of Immunology 47
Department of Logopaedics 50
Department of Medical Biochemistry 53
Department of Medical Microbiology 56
Department of Medical Physics 61
Department of Medicine 63
Department of Neurosurgery 108
Department of Nuclear Medicine 110
Department of Nursing 112
Department of Obstetrics & Gynaecology 116
Department of Occupational Therapy 122
Department of Ophthalmology 126
Department of Orthopaedic Surgery 129
Department of Otolaryngology 134
Department of Paediatric Pathology 136
Department of Paediatric Surgery 140
Department of Paediatrics & Child Health 142
Department of Pharmacology 154
Department of Physiotherapy 161
Department of Plastic, Reconstructive and Maxillo-Facial Surgery 164
Department of Primary Health Care 165
Department of Psychiatry and Mental Health 169
Department of Public Health 176
Department of Radiation Oncology 182
Department of Radiology 186
Department of Surgery 191
Department of Urology 196
HSRC/UCT Centre for Gerontology 198
FACULTY OF HEALTH SCIENCES
Dean: Professor N Padayachee Director of Research: Prof A Azad Acting Director of Educaton: N Hartman Directors of Schools: Prof D Power - Child and Adolescent Health Prof A Miller - Deputy Child and Adolescent Health A/Prof R Watson - Allied Health Sciences Prof I Parker - Basic and Applied Sciences Prof J Myers - Public Health
INTRODUCTION
The University of Cape Town has long been recognised as the pre-eminent centre for medical research in South Africa and on the African continent. The world’s first heart transplant and the pioneering research leading to the development of the CAT scanner are among the major medical discoveries that have helped put Cape Town firmly on the world map.
Over time, certain of the research programmes have become disparate, and teams have lacked critical mass and direction. On the other hand, disciplines such as the clinical, laboratory and public health personnel addressing issues of national and international importance have seen a significant increase in magnitude of research teams and funding. However, because of shrinking financial support from traditional sources there has been undue diversion of human resources and expertise away from basic clinical research (which remains a major strength in the Faculty) into externally driven contract research.
Primary and Public Health research has traditionally been neglected by the Faculty and thus needs to be strengthened as a major priority. Even with this relative lack of resources, the Primary/Public Health sectors of the Faculty have made significant advances in health care provision and have contributed to many of the clinical and laboratory studies. However, the current levels of funding and range of Faculty research activities remain diverse and thinly spread in many of the research areas. Basic biomedical research has suffered most because of a lack of these resources, focus, critical mass and world class facilities required to be internationally competitive.
Review of research practice within the Faculty shows that most medical research is carried out by post- graduate students, who are supervised by senior academics. However, because of the administrative, teaching and clinical loads placed on these supervisors, they are not able to dedicate enough of their time to the research teams that they co-ordinate. As a result, research productivity and the mentoring of research students and junior researchers has not been optimal. There is a serious lack of full time researchers such as post-doctoral fellows. It should be noted that it is researchers at this level of seniority who, together with graduate students are responsible for the vast majority of research productivity in the USA and Europe. This relative lack of trained full-time, medium-seniority researchers impedes our capability to be internationally competitive in these areas of research.
Research capacity, research culture and associated university operations need to keep pace with contemporary international practices. This is especially true of intellectual property development and its exploitation, through mutually beneficial partnerships with the pharmaceutical and biotechnology industries.
RESEARCH PLAN
The major thrust of the FHS research plan is the reorganisation and consolidation of its research activities into major initiatives centered on a small number of health care problems of national importance and in areas of existing strength. This is in recognition of dwindling sources of research funding, the need to concentrate on research objectives of direct relevance to the health, economic and social needs of South Africa, and to build up capacity and expertise in key areas that allow health research in the UCT to be of a worldclass standard. This requires:
(i) identification of niche areas and areas of strength;
1
(ii) building of multidisciplinary research teams for each major program, and project; (iii) establishment of critical mass, appropriate expertise and state of the art facilities in each of the disciplinary areas, and; (iv) awareness of intellectual property issues and willingness to collaborate with industry on an equal footing; (v) that research activities promote community needs and transformation issues (vi) strict compliance with ethical and regulatory guidelines
To bring about this change in research culture, a Research Directorate has been established within the FHS and a Research Director has been appointed.
To achieve the above objectives the Research Directorate working together with the Faculty Research Committee and the Departmental Research Committees will:
(i) Carry out an audit of all existing research activities within the FHS to identify areas of major strength where the UCT would be internationally competitive and align them to health problems of national importance; (ii) Formulate policies to: • provide special support to areas of research that had previously been neglected • enhance research profile and productivity in priority areas that need special attention • ensure that research activities are in compliance with and promote transformation, ethical and regulatory guidelines (iii) Consolidate research activities around major diseases of relevance to SA and the African continent and form multidisciplinary research teams that allows these problems to be tackled in a significant and comprehensive manner. Where this is not possible within the UCT, strategic alliances need to be established with other research groups within SA and the African continent; (iv) Carry out an audit of available expertise and major facilities to ensure that there is critical mass and world class facilities in each disciplinary area. This will be greatly strengthened by forming strong operating links with the Faculties of Science and Engineering at the UCT and with specialist groups in neighbouring universities; (v) Formulate appropriate policies for intellectual property development and commercialisation and highlight the importance of these in obtaining industry funds and setting up of industrial collaborations. This has to be done in close collaboration with the Department of Research Development and the Office of Industrial Liaison.
The recognition and implementation of appropriate solutions that meet our current limitations will result in a strengthening of research capacity. Much of this can be carried through the setting up of one or more multidisciplinary Institutes that would provide tangible benefits and opportunities not only to the UCT but also to the region.
The strategic directions being adopted for health sciences research at the UCT are also generally applicable to the rest of South Africa and the rest of the continent. It is therefore, desirable to develop joint strategies for mutual benefit, rather than working in isolation.
By sharing existing equipment and expertise, utilising African indigenous resources, and fully developing local intellectual property within the continent, Africans have the potential to effectively tackle the major health problems that affect the region.
The realisation of this vision is also dependent on the availability of a full range of contemporary enabling technologies within the continent. An African institution needs to be set up to not only provide state of the art equipment and facilities to African researchers, but to also work with various funding agencies to provide resources and opportunities for short-term fellowships, long-term fellowships, training workshops, and needs-based short visits to specialist centres. Besides increasing research activity this will enable African researchers working on collaborative projects to carry out world-class research primarily from their home base and thereby stem the brain drain out of their countries and out of Africa.
2
PROPOSED INSTITUTE OF INFECTIOUS DISEASES AND MOLECULAR MEDICINE
During the last year the UCT Strategic Committee and the UCT Council have approved the establishment of a new Institute of Infectious Diseases and Molecular Medicine that will not only allow medical research in the UCT to remain internationally competitive but would also become an African centre of excellence for contemporary enabling technologies.
The proposed Institute will bring together complementary expertise and facilities within the Faculties of Health Sciences, Science and Engineering in the UCT and specialist groups in the Universities of Western Cape and Stellenbosch to provide the capacity to carry out basic and strategic research at a level that has previously not been possible in South Africa. The Institute will foster close co-operation between basic, clinical and public health scientists for tackling health problems of national priority. This will ensure that research outcomes are directly relevant to the needs of and acceptable to the community.
The proposed Institute will concentrate on a small number of optimally supported research activities in areas of direct relevance to the health, economic and social needs of South Africa and the region. Health problems of national and regional priority will be tackled by multidisciplinary research teams with complementary expertise and facilities that would provide critical mass in each discipline and allow these problems to be tackled in a significant and comprehensive manner. The Institute will concentrate on the following Research Programs which will each consist of a small number of significant multidsiciplinary projects.
1. Viral Diseases - HIV/AIDS and Hepatitis 2. Bacterial Diseases - TB and any other Bacterial Infections 3. Parasitic Diseases - Malaria and Helminthic Infections 4. Major Cancers 5. Prevalent Genetic Disorders - (including Genomic and Bioinformatics) 6. Non-communicable Diseases and Metabolic Disorders 7. Other Diseases - Immunology/Neurology Disorders etc
A major focus of the proposed Institute will be capacity building and training of African researchers. The infrastructure that will be set up will be made available to South African and African collaborators.
Towards this end it is proposed that the Institute be established as a multi-disciplinary research institution to provide resources and opportunities for long-term fellowships, training workshops and short visits. This will be possible only through partnerships with the USHEPiA Program and major funders such as the Rockefeller Foundation, and by building on the very productive current relationships with the Wellcome Trust and the MRC.
A five day research workshop is planned for February 2001 to identify individuals and projects that would qualify for membership of the proposed Institute, and also to identify research areas in infectious diseases suitable for collaboration with the USHEPiA partner universities. The Rockefeller Foundation has provided funding for a number of joint workshops on Health Equity between USHEPiA partners to enable the drafting of a small number of significant collaborative projects. The Rockefeller Foundation will arrange to have these presented to major international funders.
RESEARCH FUNDING
Research at the Health Sciences Faculty can be broadly categorised in five main areas: public health and policy; laboratory sciences; clinical science; epidemiology; and rehabilitation medicine and medical support systems. The following are the elements of research enterprise in the faculty that together constitute its research profile.
Finance: Research is financed by the income from various trusts comprehensively managed by the Faculty Research Committee (formerly MERC) which in 2000 amounted to R3,781,053.44; designated funds for cancer research (CANSA) which in 2000 amounted to R1,047,943.00 (including VAT); the Medical Research Council which in 2000 amounted R1,615,900.00; and the National Research Foundation (NRF) which in 2000 amounted to R3,765,760.00.
3
Summary of Research Funds for Heath Sciences Faculty in 2000
FUNDING AGENCY 1999 AWDS 2000 AWDS
Research Committee (MERC) Awards 2,936,351.49 3,781,053.44
Cancer Association of South Africa (CANSA) 974,973.00 1,047,943.00
Medical Research Council (MRC) - Individual Grants 1,159,400.00 1,615,900.00
* Medical Research Council (MRC) - Research Units 2,857,198.50 4,337,582.00
** National Research Foundation 4,125,797.00 3,765,760.00
12,053,719.99 14,548,238.44 * Includes Assistantship Posts ** This reflects claimed amount, ie actual revenue we will receive, not awarded amounts.
RESEARCH UNITS AND CENTRES
The research units in the Health Sciences Faculty attract a large proportion of funding, primarily but not solely from the Medical Research Council. These units also account for much of the postgraduate training in research, which plays a major role in future leadership in research at the university, and the country.
The research units and centres in the Health Sciences Faculty are listed in the Table below.
RESEARCH UNIT DIRECTORS
Cardiovascular Research Unit Prof Zilla
Heart Research Unit Prof LH Opie
Hatter Institute for Cardiology Research Dr M Sack
Lipid Unit Dr D Marais
Traditional Medicines Unit Prof P Folb
Liver Research Centre Prof RE Kirsch
Oesophageal Cancer Research Group Prof I Parker
Bioenergetics of Exercise Research Group Prof T Noakes
Centre of Gerentology Dr M Ferreira
Industrial Health Research Group Mr N Henwood
Institute of Child Health Prof DW Beatty
Occupational Health Research Group Prof J Myers
4
Leukaemia Centre Prof N Novitzky
Women’s Health Research Unit Prof M Hoffman
Health Economics Unit Prof D McIntyre
Child Health Unit Prof M Jacobs
Lung Institute Prof E Bateman
WHO Collaborating Centre for Drug Policy Prof P Folb
UCT Medical Imaging Research Unit Prof K Vaughan
Infectious Immunology Assoc. Prof F Brombacher
Genomics Prof Raj Ramesar
Major sources of research funding have also come from DACST and the Wellcome Trust.
Innovation Funds (DACST)
The UCT Health Sciences Faculty has 3 DACST innovation awards amounting to 21 Million Rand.
Prof P Folb - Department of Pharmacology A/Prof A-L Williamson, Division of Medical Microbiology Prof K Vaughn - Department of Human Biology
Wellcome Trust - supported Individuals and Projects
Prof Frank Brombacher: Wellcome Senior Research Fellow. Prof Peter Meissner: Wellcome Senior Research Fellow. Prof A Katz: Wellcome Senior Research Fellow. Prof David Beatty: Childhood TB. Prof Bernard Ryffel: TB Research. Dr Daan Steenkamp: TB Research. Dr Ed Sturrock: 3D structure of ACE
RESEARCH OUTPUT
The Research Output of the Faculty of Health Sciences is reflected on the following Table. Changing trends over the period 1993 - 1999 are reflected in the Table.
1993 1994 1995 1996 1997 1998 1999 Journal 483 422 392 367 397 379 404 Articles Books 6 3 8 13 16 15 15 Chapters in 30 82 159 58 49 103 127 Books Published 32 8 23 92 62 64 87 Conference Proceedings
University 216 301 279 350 364 416 289 and Other Publications TOTAL 767 816 861 880 888 977 922
5
POSTGRADUATE STUDENTS
At the heart of the research initiative of the institution lies its capacity to provide excellent opportunities, facilities and training for postgraduate students. This applies to every level of research training, from honours to doctoral studies. A breakdown for the year 2000 enrolment of postgraduate students in the faculty is provided in the following Table.
Degree Total White Coloured Indian Black Male Female MEDG07 9 3 2 - 4 4 5 MEDG09 41 5 6 2 28 16 25 MEDH01 59 36 8 4 11 13 46 MEDM01 405 278 39 38 50 281 124 MEDM02 18 16 1 - 1 - 18 MEDM04 1 - - - 1 - 1 MEDM05 14 9 4 - 1 - 14 MEDM06 77 45 11 6 15 44 33 MEDM08 1 - 1 - - - 1 MEDM09 21 16 2 3 - - 21 MEDM10 2 2 - - - - 2 MEDM11 7 3 2 2 - 5 2 MEDM12 16 3 4 1 8 9 7 MEDM95 101 67 13 3 18 49 52 MEDD01 140 86 19 6 29 83 57 MEDD02 21 18 1 2 - 19 2 MEDM04 1 - - - 1 - 1 TOTAL 936 590 113 67 166 525 411
Key: MEDG07 - Postgraduate Diploma in Occupational Health MEDG09 - Postgraduate Diploma in Health Management MEDH01 - BSc (Med) ) (Hons) MEDM01 - Master of Medicine (Mmed) MEDM02 - MSc Nursing MEDM04 - MSc Physiotherapy MEDM05 - MSc Occupational Therapy MEDM06 - Mphil MEDM08 - MSc Audiology MEDM09 - MSc Speech and Language Pathology MEDM10 - Msc in Nutrition and Diet MEDM11 - Master of Family Medicine MEDM12 - Master of Public Health MEDM95 - MSc (Med) MEDD01 - PhD MEDD02 - Doctor of Medicine MEDM04 - ChM
For purposes of comparison, data is provided in the following Table for Undergraduate students registered in the Faculty (total numbers only, for all programmes, are provided).
Statistics as at 15 August 2000.
Degree Total White Coloured Indian Black Male Female All U/G 1 531 722 228 197 384 470 1 061
6
DEAN's REPORT ON RESEARCH TO THE FACULTY
Research at our Faculty received a boost with the appointment of a Research Director, Professor Ahmed Azad, in January 2000. Top of his agenda during the past year has been the establishment of our new Institute of Infectious Diseases and Molecular Medicine. The University Council approved our business and funding proposal and agreed to contribute a significant portion (approximately R7million) towards the construction of the building to accommodate the Institute. UCT’s Development Office has prioritised the funding of the costs. A project manager and an architect were seconded from the central Properties & Services administration to oversee the project, and it is hoped that construction will commence in 2001.
Collaborative partnerships were established with research groups within South Africa and Southern and East Africa through the extension of the existing USHEPIA programme. Funds have been made available by the Rockefeller Foundation through the International Academic Programmes Office to enable the Faculty to drive a health sector collaboration with English language-speaking, sub-Saharan institutions. A new, externally funded Chair of Virology was established and filled; and a significant donation has been made by an external donor towards the Chair and research in the UCT/MRC Research Unit for Exercise Science & Sports Medicine. The Medical Research Council has agreed to fund a senior research scientist in the HSF.
In the interest of revitalising our research support structures and procedures to maintain international standards we are in the process of setting up a new Faculty Research Committee with representatives from the 11 new departments and the Faculty’s major Institutes. We have also established two new Ethics committees – one dealing with human and the other with animal ethics.
DEAN's REPORT TO THE FACULTY ON EQUIPMENT
The central UCT Equipment Committee allocated R595 000 towards research equipment in the Faculty of Health Sciences in 2000, R500 000 of which was used towards purchasing a mass spectrometer.
REPORT OF RESEARCH ETHICS COMMITTEES
The newly established Research Ethics Committee came into operation in 2000. This Committee is divided into two namely, the Animal and Human. The Committee is co-chaired by Profs. C Swanepoel (Human) and D. Kahn (Animal).
The committee activities have been aligned with the MRC/ICH GCP guidelines.
The in-house training of members started with the excellent course organised by Prof. Benatar. Other talks are planned to be for an ongoing education programme. The Committee meets regularly. The Human Ethics meets every last Friday of each month and the Animal ethics during the middle of the second month. The committee has received 336 protocols in 2000. 306 studies have been approved and 30 not approved. 326 are in -house research.
Professor Ahmed Azad Director of Research, Faculty of Health Sciences
7
7
DEPARTMENT OF ANAESTHESIA
HEAD OF DEPARTMENT – Professor MFM James
DEPARTMENT CONTACT DETAILS Postal Address: Department of Anaesthesia Room 80, D23 New Groote Schuur Hospital Main Road Observatory 7925 South Africa UCT Telephone: SA (21) 406-6143 GSH Telephone: SA (21) 404-5004 Fax: SA (21) 447-5206 Email: [email protected]
DEPARTMENTAL PROFILE
Despite a continuing decline in the available staff, and increased pressure of clinical work, the department has maintained research output for this year. This is due entirely to the dedication and enthusiasm of staff members who have committed their personal time to research. The gradual growth of a stable senior staffing echelon has contributed to this and the department is now developing a good cadre of research minded individuals. The department has been fortunate in being able to attract several reasonably well-funded clinical trials, and this should expand our financial base with which to support further research. The studies of haemodilution-associated increases in coagulation continue to play a major part in the research profile of the department and a collaborative project with University College Hospital, London, in this field has been established, with a fully-funded research fellow from UCH spending this year at UCT. The collaboration with Adelaide University has continued successfully and has resulted in two publications and two further studies in preparation for publication. The unique clinical material available at the Red Cross Children's Hospital has continued to attract contract clinical research, but has also provided a base for registrar research, and a further MMed thesis is in preparation arising from work conducted in this institution. Studies in thoracic anaesthesia and anaesthesia for phaeochromocytoma are continuing.
DEPARTMENTAL STATISTICS 2000
HONORARY STAFF (Hospital Services) PERMANENT AND LONG TERM CONTRACT STAFF Senior Lecturers 6
Research Technologists 1 Professors 2 Administrative and Clerical staff 1 Emeritus Professor 1 TOTAL 8 Associate Professor 1 Principal Specialists 3 Senior Specialists/Lecturers 8 STUDENTS Specialists/Lecturers 13 Registrars 44 Postgraduates 44 Administrative staff and Clerical 2 Undergraduates 170 Staff TOTAL 214 TOTAL 74
8
RESEARCH FIELDS
Dyer, RA total intravenous anaesthesia; aspects of anaesthesia in patients with severe pre-eclampsia James, MFM (Head of Department) the role of magnesium in the treatment of malignant arrhythmias in association with anaesthesia; control of pulmonary shunting during one-lung anaesthesia, blood transfusion and anesthesia, haemodilution and coagulation; crystalloid v. colloid in trauma resuscitation; efficacy and safety of melagatran H376/95 compared with enoxaparin as prophylaxis against venous thromboembolism; blood coagulation in patients with chronic renal failure a thromboelastographic study Heijke, SAM transoesophageal echocardiography in cardiac anaesthesia Reid, A intravenous regional anesthesia and the role of morphine; magnesium in the treatment of bupivacaine toxicity; the role of magnesium in anaesthesia for patients undergoing cerebral aneurysm surgery Ruttmann, TG Interaction of various intravenous solutions and anaesthetic techniques on coagulation; ICU care with Diprivan; the effects of intra-venous fluid management with either colloid or a crystalloid on coagulation in patients undergoing peripheral vascular surgery; remifentanil and midazolam regiment versus a morphine and midazolam regimen in Intensive Care Unit patients; the effects of increasing haemodilution on coagulation Viljoen, JF management of pain particularly in post-thoracotomy patients; national collaborative study on low flow and closed circuit anaesthesia Whitehead, P cardiotoxity of ropivacaine versus bupivacaine Evans, N Studies on the intubating LMA; LMA proseal in isolating respiratory and alimentary tracts; descriptive trial on the new LMA proseal Gardner, S rocuronium for Rapid Sequence Induction [RSI]; investigation into the benefits of perioperative skin surface warming in cardiac surgical patients; gender issues in anaesthesia H van Dyk a phase I, single-center, open-label study evaluating the pharmacokinetics and pharmacodynamics of dexmedetomidine in paediatric patients Roche, T coagulation calcium concentration on citrated whole blood; coagulation effects of in vivo haemodilution with physiologically-based and non-physiologically based starch solutions; coagulation effects of acute normovolaemic haemodilution with hydroxyethyl starches Rous, SA the interaction between rocuronium and thiopentone Thomas, J epidural infusion of ropivacaine
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Gordon, P.C. & James, M.F.M. 2000 Anaesthesia in rural hospitals. South African Medical Journal 90(4): 326-327[Letter to Editor]. Botha, J.F., Spearman, C.W., Millar, A.J.W., Michell, L., Gordon, P.C., Lopez, T., Butt, A., Thomas, J., McCulloch, M., James, M.F.M., Kirsch, R.E., Terblanche, J. & Kahn, D. 2000. Ten years of liver transplantation at Groote Schuur Hospital. South African Medical Journal 90(9):880-883. James, M.F.M. & Hift, R.J. 2000. Porphyrias. British Journal of Anaesthesia 85(1):143-153 . Dyer, R.A., Heijke, S.A.M., Russell, J., Bloch, M. & James, M.F.M. 2000. Can insertion length for a double lumen intubation be predicted? 2000 Anaesthesia and Intensive Care 28: 666-668.
9
Russell, W.J. & James, M.F.M. 2000. The effects of increasing cardiac output with adrenaline or isoprenaline on arterial haemoglobin oxygen saturation and shunt during one lung ventilation. Anaesthesia and Intensive Care 28: 636-641.
UNIVERSITY PUBLICATIONS AND PUBLICATIONS OF A POPULAR NATURE
Thomas, J. 2000. Challenges in paediatric pain management. Specialist Medicine May:280-288. Viljoen, J.F. 2000. Decision-making in anaesthesia: The influence of non-scientific factors. Specialist Medicine May: 268-270.
CONFERENCE ABSTRACTS
Bass, B. 2000. Nerve blocks – do they play a role in chronic pain management? South African Society of Anaesthesiologists Congress, Cape Town. Bloch, M. 2000. Post-thoracotomy pain relief. South African Society of Anaesthesiologists Congress, Cape Town. Bloch, M. 2000. The educational value of anaesthesia simulators. South African Society of Anaesthesiologists Congress, Cape Town. Dyer, R.A. 2000. The effect of tramadol on post-thoracotomy pain. American society of anesthesiologists, San Francisco, California. Evans, N. 2000. Haemodynamic responses to tracheal intubation using the intubating laryngeal mask. 12th World Congress of Anaesthesiologists, Montreal, Canada. Evans, N. 2000. The role of the laryngeal mask and the intubating laryngeal mask in the management of the difficult airway. South African Society of Anaesthesiologists Congress, Cape Town. Evans, N. 2000. Haemodynamic responses to tracheal intubation using the intubating laryngeal mask. American Society of Anesthesiologists, San Francisco, California. Gardner, S. 2000. Intraoperative warming and post-operative coagulation status during cardiac surgery. American Society of Anesthesiologists, San Francisco, California. James, M.F.M. 2000. Hemodynamic management strategies. 12th World Congress of Anaesthesiologists, Montreal, Canada. James, M.F.M. 2000. Anaesthesia for carotid endarterectomy. South African Society of Anaesthesiologists Congress, Cape Town. James, M.F.M. 2000. VIMA in low flow anaesthesia. South African Society of Anaesthesiologists Congress, Cape Town. Lopez, T.J. 2000. The ethics of paediatric pain management. South African Society of Anaesthesiologists Congress, Cape Town. Lopez, T.J. 2000. Management of the difficult paediatric airway. South African Society of Anaesthesiologists Congress, Cape Town. Lopez, T.J. 2000. Emergency surgery: paediatric trauma – severe burns; ventriculo-peritoneal shunt – raised intracranial pressure. South African Society of Anaesthesiologists Congress, Cape Town. Reed, A. 2000. Anaesthesia for cerebral aneurysm surgery. South African Society of Anaesthesiologists Congress, Cape Town. Roche, T. 2000. In vitro serial haemodilution with a balanced electrolyte hetastarch solution (Hextend) and TEG analysis. American Society of Anesthesiologists, San Francisco, California. Ruttmann, T. 2000. Proagulant effects of haemodilution are attenuated by keeping antithrombin III levels constant. American Society of Anesthesiologists, San Francisco, California. Ruttmann, T. 2000. Haemodilution enhances coagulation: A caveat. 12th World Congress of Anaesthesiologists, Montreal, Canada. Ruttmann, T. 2000. Pros and cons: difficult intubation – awake or asleep? South African Society of Anaesthesiologists congress, Cape Town. Thomas, J. 2000. Advanced paediatric life support. South African Society of Anaesthesiologists Congress, Cape Town. Thomas, J. 2000. Medical disorders- haemorrhagic diseases; meningococcaemia; Stevens-Johnson Syndrome; Epidermolysis Bullosa. South African Society of Anaesthesiologists Congress, Cape Town.
10
DEPARTMENT OF ANATOMICAL PATHOLOGY (Including the Cytopathology Laboratory and UCT Mortuary)
HEAD OF DEPARTMENT: Professor JP Cruse
DIRECTOR OF RESEARCH: Professor P de la M. Hall
DEPARTMENTAL CONTACT DETAILS
Postal address: Department of Anatomical Pathology University of Cape Town Medical School Anzio Road Observatory 7925 South Africa Telephone: SA (21) 406-6162 Fax: SA (21) 448-1789 e-mail: [email protected]
DEPARTMENTAL PROFILE
The Wernher and Beit Chair of Anatomical Pathology was established in 1918, and the department shortly afterwards. The Department of Anatomical Pathology is a large University department with extensive undergraduate teaching commitments to medical and dental students, the Allied Health Sciences and various Technikons. In addition, the department has major diagnostic service commitments to the Groote Schuur Hospital region, including over 200 primary healthcare and community clinics throughout the Western Cape, for histopathological (surgical pathology), autopsy (adult and perinatal autopsies) and cytopathology services. The department also serves as a public and private tertiary referral centre for renal and liver pathology, neuropathology, immunocytochemistry, electron microscopy and molecular pathology. There is a Paediatric Pathology service, covering all disciplines of pathology, based at Red Cross Hospital . These service commitments drive most of the research programmes which are patient-and disease-orientated.
The departmental research is focused on diseases that are common in South Africa such as tuberculosis, viral infections (HIV, HPV, HBV) and various cancers, particularly those affecting disadvantaged populations groups, such as oesophageal, cervical and prostatic carcinoma.
Apart from its own active research programmes the department also collaborates closely with the departments of Medicine, Surgery, Obstetrics and Gynaecology, with other faculties within the University of Cape Town, with colleagues at the Universities of Stellenbosch, the Western Cape and with other South Africa universities. The department has international research collaborations with colleagues in Australia (the Institute of Medical and Veterinary Scince, Adelaide, Flinders University of South Australia; Storr Liver Unit, Westmead Hospital, Sydney; Murdoch University, Perth; University of Western Australia); Europe (University of London, University of Leiden, Groningen University, the Netherlands; Georg-August University, Goettingen, Germany) and with institutions in the United States (Cornell University in New York, University of Arizona, Tucson, Arizona).
During 2000, the service departments of the Department were amalgamated with those of the Department of Oral Pathology & Maxillofacial Pathology & WHO Centre for Oral Cancer, University of the Western Cape. Prof Joss Hille and Emeritus Mervyn Shear therefore join the department in a long-term collaborative move, which will strengthen the combined diagnostic services as well as increasing research and teaching outputs.
11
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG-TERM CONTRACT STAFF ON RED CROSS STAFF ESTABLISHMENT Professors 2 Professors 2 Senior Lecturers 4 Lecturers 1 Lecturers 2 TOTAL 3 Scientists and Research Staff 1 Administrative, Clerical and Support Staff 9 STAFF ON UWC TOTAL 18 ESTABLISHMENT
Professors 2
TOTAL 2 HONORARY STAFF Honorary Lecturers 2 TOTAL 2
STUDENTS PhD 4 DPhil (Paediatric Pathology) 1 Masters (MMed) 8 Masters (MBA) 1 Undergraduate (MBChB) 192 Allied Health Sciences 66 BTech (Cape Technikon) 33 BChD (UWC) 36 TOTAL 341
RESEARCH FIELDS
Professor J. P. Cruse Head of Department, Professor Cruse is interested in the application of modern business methods to the management of Pathology laboratories (he is currently registered for the 2 year part-time Executive MBA at the Graduate School of Business, UCT); Epidemiological studies on the prevention of causation of human cancers; gastrointestinal histopathology; the histogenesis of human colonic, gastric and pancreatic cancers, the epidemiology of cancers; digital image analysis and morphometry, cancer registry Professor P. de la M. Hall Hepatobiliary disease including - alcohol and drug related liver injury; hepatic neoplasms; primary and secondary iron overload; hepatic infections including hepatitis B in animal models, and schistosomiasis; non-alcoholic steatohepatitis in humans and animal models, hepatic stem cells in human liver disease and animal models for hepatocarcinogenesis; also a range of neoplasms including carcinoma of the oesphagus, colon, pancreas, prostate and cervix Professor J. Hille pathology, pathogenesis and epidemiology of head and neck pathology, and in particular salivary gland tumours; the role of myoepithelial cells in head and neck tumours Dr R. M. Bowen Principal Specialist and Senior Lecturer; neuropathology of patients with chronic mental handicaps; ophthalmic and otorhinolaryngologic pathology; head of the diagnostic histopathology service Dr M. S. Duffield Senior Lecturer; geographic distribution of cancer of the cervix; application of immunogold and electron microscopy to the ultrastructural diagnosis of tumours, renal biopsies and pathology of transplanted organs Dr G. Langman Lecturer; the role of non-alcoholic steatohepatitis in methotrexate induced liver injury in psoriatic patients, human herpes virus 8 in inflammatory myofibroblastic tumours
12
Dr B. K. Knight Senior part-time lecturer; the prevalence and morphology of chlamydia infection in Papanicolaou smears by morphological and molecular techniques; comparison of methods for optimal collection for cervical smears Dr D. A. Taylor Senior Lecturer; light microscopy and immunocytochemistry of human soft tissue tumours Dr K. Taylor Lecturer; Special interest in lymphomas Dr A. Timme the pathology of malignant melanomas in the Western Cape; dermatopathology; lymphomas Dr H. C. Wainwright Senior Lecturer; neonatal and paediatric pathology; investigation of congenital malformation; morphological examination of human placentas; congenital heart disease; endothelial damage in pregnancy-induced hypertension; congenital syphilis; foetal alcohol syndrome in collaboration with the Foundation for Alcohol Related Research headed by Professor Denis Viljoen; also a cervical pathology project with Dr Lynn Denny Dr J. Whittaker Part-time lecturer; the evaluation comparison between PAPNet and AutoPAP automated cytology screening system
DISTINGUISHED VISITORS
Dr V. Anderson Brooklyn Health Science Centre, New York Dr A.J. Bourne Women’s and Children’s Hospital, Adelaide, South Australia Prof G.C. Farell Westmead Hospital, Sydney, Australia Prof J. Jass University of Queensland, Australia Dr I. Leclercq Westmead Millennium Institute, University of Sydney, Australia Prof D.C. Mangham Royal, Orthopaedic Hospital, Birmingham Dr S. Orrell Clinpath, Adelaide, South Australia Dr T. Schlott Georg-August University, Goettingen, Germany Prof A. Tiltman University of Witwatersrand Prof K. Unni Mayo Clinic, Rochester, Minneapolis, USA Dr C. Vessey University College, London
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Brandwein, M., Hille, J.J., Gnepp, D., Urken, M.L. & Ivanov, K. 2000. The many faces of mucoepidermoid carcinoma. Pathology case reviews 5(4): 214-220. Denny, L., Kunn, L., Pollack, A., Wainwright, H. & Wright, T.C. 2000. Evaluation of alternative methods of cervical cancer screening for resource-poor settings. Cancer 89: 826-833. Kirsch, R., Woodburne, V.E., Shephard, E.G. & Kirsch, R.E. 2000. Patients with stable uncomplicated cirrhosis have normal neutrophil function. J Gastroenterol & Hepatol 15: 1298-1306. Langman, G. & Hewlett, R. 2000. Intravascular lymphoma – test and teach. Pathology 32: 116-117, 136. Plummer, J.L., Ossowicz, C.J., Whibley, C., Ilsley, A.H. & Hall, P. de la M. 2000. Influence of intestinal flora on the development of fibrosis and cirrhosis in a rat model. J Gastroenterol & Hepatol 15: 1307-1311.
13
Ramesar, R.S., Madden, M.V., Felix, R., Harocopas, C.J., Westbrook, C.A., Jones, G., Cruse, J.P. & Goldberg, P.A. 2000. Molecular genetics improves the management of hereditary nonpolyposis Colorectal Cancer. South African Medical Journal 90(7): 709-714. Wemyss-Holden, S.A., Robertson, G.S.M., Dennison, A.R., Hall, P. de la M., Fothergill, J.C., Jones, B. & Maddern, G.J. 2000. Electrochemical lesions in the rat liver supports its potential for treatment of liver tumours. Journal of Surgical Research 93: 55-62.
PUBLISHED CONFERENCE PROCEEDINGS
Hall, P. de la M. 2000. Essentials and the course of the pathological spectrum of alcoholic liver disease in man. ISBRA, Yokohama, Japan. Alcoholism: Clinical & Experimental Research 24 (suppl) WS11.1, 192A. Kirsch, R., Shepherd, E., Kirsch, R. & Hall, P. de la M. 2000. The rat nutritional model for steatohepatitis: Strain and gender studies. IASL/APASL, Fukuoka, Japan. J Gastroenterol & Hepatol 15 (suppl): F81. Kaschula, R.O.C. 2000. An analysis of 32 PNET/Ewing's sarcoma cases from Red Cross Children's Hospital, Cape Town, South Africa. XXIII International Congress of International Academy of Pathology, Nagoya, Japan. Pathology International 50 (suppl): FP-27-19. Learmouth, G. 2000. Fine Needle Aspiration of Ganglioneuromatous Neoplasms. University of Cape Town and University College of London Hospital. Pathologia 38: 40 (A138). Leclercq, I., Do, L., Farrell, G.C., Hall, P. de la M. & Robertson, G.R. 2000. Gender and Th-cell cytokine profile influence the pattern of liver injury in murine NASH. Presented at the Australian Gastroenterology Week, Hobart. J Gastroenterol & Hepatol. 15 (suppl): J 41. Robertson, G.R., Farrell, G.C. & Hall, P. de la M. 2000. Gender and TH-cell cytokine profile influence the pattern of liver injury in murine NASH. Presented at the American Association for the Study of the Liver Meeting, Dallas. Hepatology 32: A196, #133. Seedall, R.J., Learmouth, G. & Kocjan, G. 2000. ThinPrep 2000 versus conventional preparation Methods for non Gynaecological specimens, Royal Free Hospital and University College Medical School, University College London. Cytopathology 11: 10 (Suppl), 8.
ABSTRACTS PRESENTED AT SCIENTIFIC CONFERENCES
Breeuwsma, A.J., Hall, P. de la M., Krige, J.E.J., Bornman, C. & Terblanche, J. 2000. Prognostic factors in patients presenting with bleeding varices treated with sclerotherapy. Presented at the Surgical Research Society meeting, Cape Town. Langman, G., Engel, M. & Sinclair-Smith, C. 2000. Human herpes virus 8 in inflammatory myofibroblastic tumours. Presentation at the 40th Annual Congress of the Federation of South African Societies of Pathology, Warmbaths. Langman, G. 2000. Pathology of colorectal cancer in a large South African family. Colorectal Cancer Symposium, Cape Town. Langman, G. 2000. Pathology of the duodenum. Approach to biopsy interpretation. 40th Annual Congress of the Federation of South African Societies of Pathology, Warmbaths. Davies, J.Q. & S-Smith, C. 2000. Interdigitating dendritic cell sarcoma - a report of three cases at Red Cross Children's Hospital. Presented at Red Cross Children’s Hospital Research day. Davies, J. & S-Smith, C. 2000. Interdigitating dendritic cell sarcoma - a report of 3 cases at Red Cross Children's Hospital. PATH 2000, The 40th Annual congress of the Federation of South African Societies of Pathology, Warmbaths. de Vries, D., Hall, P. de la M., Krige, J.E.J., Bornman, P.C. & Terblanche, J. 2000. Solid-cystic- papillary tumours of the pancreas. The use of Immunohistochemical detection of mismatch repair deficit in patients with colorectal cancer. Presented at the Surgical Research Society meeting, Cape Town. Duffield, M. 2000. Classification of Renal Disease. Presented at a joint International Society of Nephrology (ISN) and African Association of Nephrology (AFRAN) meeting, Aga Khan Hospital, Nairobi. Duffield, M. 2000. Focal Segmental Glomerulosclerosis. Presented at a joint International Society of Nephrology (ISN) and African Association of Nephrology (AFRAN) meeting, Aga Khan Hospital, Nairobi. Duffield, M. 2000. The smear technique in neuropathology. Presented at the Bergpath Meeting, Drakensberg.
14
Engelbrecht, G., Hudson, D.A. & Seymour, B. 2000. A Modified technique of arterial sleeve anastomosis in microsurgery. Presented at the Surgical Research Society 2000 Meeting. Hall, P. de la M. 2000. Non-alcoholic steatohepatitis. Presented at the Bergpath Meeting, Drakensberg. Hall, P, de la M. 2000. Pregnancy-related liver disease. Presented at the Bergpath Meeting, Drakensberg. Hall, P. de la M., Wemyss-Holden, S., Robertson, G., Dennision, A., Fothergill, J. & Maddern, G. 2000. The natural history of electrochemical lesions in the rat liver support its potential for the treatment of unresectable liver tumours. Division of Pathology Research Day. Hall, P. de la M. 2000. Chronic viral hepatitis. Presented at Association of Pathologists from East, Central and Southern Africa (APECSA), Victoria Falls, Zimbabwe. Hall, P. de la M. 2000. Pathology and classification of autoimmune hepatitis. Presented at the 5th Meeting of the African Association for the Study of Liver Disease (AASLD), Sun City. Hall, P. de la M. 2000. Pathology of alcoholic and non-alcoholic steatohepatitis. Presented at the 5th Meeting of the African Association for the Study of Liver Disease (AASLD), Sun City. Hall, P. de la M., Hairwadzie, H. & Spearman, W. 2000. Case presentations/panel discussion. Presented at the 5th Meeting of the African Association for the Study of Liver Disease (AASLD), Sun City. Hameed, F., Hall, P., Algar, U., Felix, R., Ramesar, R.S. & Goldberg, P.A. 2000. The use of immunohistochemical detection of mismatch repair deficit in patients with colorectal cancer. Presented at the Surgical Research Society meeting, Cape Town. Hofmeyr, M., Williamson, A.L., Jabour, M. & Hall, P. de la M. 2000. The role of Cox 2 in cervical pathology. Presented by P Hall at the Division of Pathology research day. Hofmeyr, M., Williamson, A.L., Jabour, M. & Hall, P de la M. 2000. The role of Cox 2 in cervical pathology. Presented at the 40th Conference of the Federation of the South African Societies of Pathology (FSASP), Warmbaths. Kaschula, R.O.C. 2000. Osseus Ewing's Sarcomas seen at Red Cross Children's Hospital over 35 years. Federation of SA Societies of Pathology, Warmbaths, South Africa. Kaschula, R.O.C. 2000. Intestinal Dysmotality childhood. Association of Pathologists from East, Central and Southern Africa (APECSA), Victoria Falls, Zimbabwe. Kaschula, R.O.C. 2000. Human herpesvirus-8 in kaposi sarcoma patients of Africa: Does it play a role? Association of Pathologists from East Central & Southern Africa (APECSA), Victoria Falls, Zimbabwe. Kaschula, R.O.C. 2000. Childhood peripheral primitive neuroectodermal tumours in Cape Town. Paediatric Pathology Society, Edinburgh, UK. Kirsch, R., Shephard, E., Kirsch, R. & Hall, P. de la M. 2000. The rat nutritional model of non- alcoholic steatohepatitis: strain and gender studies. Presented at the Division of Pathology Research Day. Kirsch, R., Shephard, E., Woodburne, V.E., Kirsch, R.E. & Hall, P. de la M. 2000. Rodent models of non-alcoholic steatohepatitis: Comparative studies in rats and mice. Presented at the 3rd AstraZenica Medical Research Day, University of Stellenbosch. Kirsch, R., Shephard, E., Woodburne, V.E., Kirsch., R.E. & Hall, P. de la M. 2000. Rodent models of non-alcoholic steatohepatitis: Comparative studies in rats and mice. Dept of Medicine Research Day, UCT. Langman, G. & Hall, P. 2000. Histological assessment of sequential liver biopsies during long-term methotrexate therapy for psoriasis. Presented at the Division of Pathology Research Day. Langman, G. & Hall, P de la M. 2000. The role of non-alcoholic steatohepatitis (NASH) in methotrexate-induced liver injury. SAGES, Namibia. Mall, A., Suleman, N., Kidd, M., Taylor, K., Tyler, M., Lotz, Z., Hickman, R. & Kahn, D. 2000. The incidence of Helicobacter Heilmannii in the normal pig stomach. Presented at the Surgical Research Society 2000 Meeting. Mall, A., Suleman, N., Kidd, M., Taylor, K., Tyler, M., Lotz, Z., Hickman, R. & Kahn, D. 2000. Is there an association between H Heilmanni infection mucus degradation and ulceration of the pars oesophagea of the abattoir pig stomach? Presented at the Surgical Research Society 2000 Meeting. Mall, A., Hall, P., Barnard, R., Ho, S.B., von Rensburg, M. & Kahn, D. 2000. The expression of mucin in cholangiocarcinome. An immunohistochemical study. Presented at the International Mucin Meeting, Cambridge.
15
Mall, A.S., Dent, D.M., Hickman, R., Taylor, K., Kahn, D., McLeod, H., Lotz, Z. & Tyler, M. 2000. The expression of mucins in diseases of the stomach and liver. A biochemical and immunohistochemical analysis. 5th International Symposium on the impact of cancer biotechnology on predictive oncology and therapy, Geneva, Switzerland. Solomon, R. & Duffield, M.S. 2000. Expression of surface adhesion molecules and relation to metastases in vulval carcinomca. PATH 2000, the 40th Annual congress of the Federation of South African Societies of Pathology, Warmbaths. Struwe, F.G. & Kaschula, R.O.C. 2000. Rhinosporidiosis as seen in Cape Town, South Africa. Paediatric Pathology Society, Edinburgh, UK. Struwe, F.G., Davies, J.Q, Andronikou, S., Fieggen, A.G. & Kaschula, R.O.C. 2000. Clinical pathological findings in 3 cases of hemimegalencephaly. University of Cape Town, Institute of Child Health Annual Research Day, Cape Town. Struwe, F.G. & Kaschula, R.O.C. 2000. Rhinosporidiosis as seen in Cape Town. University of Cape Town, Institute of Child Health Annual Research Day, Cape Town. Taylor, K. & Langman, G. 2000. Crohn’s involvment of the stomach. The Cape Town experience –, A Kummer. Presentation at the 40th Annual Congress of the Federation of South African Societies of Pathology, Warmbaths. Vessey, C., Hall, P. de La M. & Gelderblom, W. 2000. A protocol for oval cell generation in Fischer rats. Presented at SAGES, Namibia. Wainwright, H. & Duffield, M. 2000. An unusual case of arthrogryposis. 40th Annual Congress of the Federation of South African Societies of Pathology, Warmbaths. Wainwright, H. 2000. Classification of interstitial lung disease. 40th Annual Congress of the Federation of South African Societies of Pathology, Warmbaths.
THESES AND DISSERTATIONS PASSED FOR HIGHER DEGREES
Denny, L. 2000. An evaluation of alternative strategies for the prevention of cervical cancer in low resource settings: 1-177. Ph.D. (Anat Path) thesis, University of Cape Town. Hofmeyr, M. 2000. Cyclooxygenase –2 in cervical neoplasia and the relationship with specific human papillomavirus types: 1-76. M.Med. (Anat Path) dissertation, University of Cape Town. Lemmer, E.R. 2000. The fumonisin B1-fed rat as a model for liver injury, oval (‘progenitor’) cell proliferation and carcinogenesis: 1-187. Ph.D. (Medicine) thesis, University of Cape Town.
16
DEPARTMENT OF CARDIOTHORACIC SURGERY (Cardiovascular Research Unit)
HEAD OF DEPARTMENT: Professor Ulrich O. von oppell
DEPARTMENTAL CONTACT DETAILS
Postal address: Department of Cardio-Thoracic Surgery University of Cape Town School of Medicine Observatory 7925 Cape Town Telephone: SA (21) 406-6181 Fax: SA (21) 448-1145 E-Mail: [email protected]
DEPARTMENTAL PROFILE
The Department of Cardiothoracic Surgery at the University of Cape Town provides clinical and training services in cardiac and thoracic surgery at both Groote Schuur and Red Cross Children’s Hospitals. The clinical services have been further reduced by the Provincial Administration of the Western Cape because of budgetary constraints, which has impacted on our ability to train registrars in the various surgical procedures. The progressive change in the category of heart valves implanted adults in our Department is illustrated in the following illustration. In addition, our drive towards off-pump coronary artery bypass graft surgery is depicted in the subsequent illustration.
Type of Valve Procedure - UCT Isolated CABG Surgery - UCT
100% Bioprostheses 100% CPB 80% Mechanical 80% Off-pump Repair 60% 60% 40% 40% 20% 20%
% of All Valve Surgery Valve % All of 0% 0% 3 6 7 8 9 1998 1999 2000 9 9 994 995 9 9 199 1 1 199 199 1 1 2000 Year of Surgery
The department hosts the Cardiovascular Research Unit situated in the SAMIOT building, Medical School.
17
DEPARTMENTAL STATISTICS
PERMANENT AND LONG TERM CONTRACT STAFF UCT conditions of service 2000 Provincial conditions of service 2000 Professors 2 Associate Professors 1 Research Staff - UCT 1 Senior Lecturers 2 Research Staff - Contract 12 Lecturers (Part time - sessions) 2 Technical Support Staff 3 Research Staff 2 Administrative & Clerical Staff 4 Clinical Technologist - Perfusion 3 TOTAL 22 Clinical Technologist - Intensive care 1 Administrative & Clerical Staff 1 TOTAL 12
STUDENTS Doctoral 5 Masters MMed – Cardiothoracic 7 MSc 3 Honours 1 Diploma Clinical Technology 2 TOTAL 18
RESEARCH FIELDS
PERMANENT STAFF
Prof U O Von Oppell Head of Department; myocardial preservation; spinal cord protection during aortic surgery; arrhythmia surgery; mitral valve repair surgery; stentless valve surgery; off-pump coronary artery bypass graft surgery; minimally invasive approaches to cardiac surgery; surgery for atrial fibrillation Prof P Zilla Director Cardiovascular Research Unit; tissue engineering of cardiovascular implants Assoc. Prof. M De Groot Head of Thoracic Surgery; oesophageal carcinoma; lung carcinoma; surgery for tuberculosis Dr J Brink Head of Heart and Lung Transplantation; Cyclosporin toxicity; post heart transplantation hypertension and renal dysfunction; surgical alternatives to transplantation; homograft and autograft aortic valve replacement surgery; xenotransplantation Dr J Hewitson Head of Paediatric cardiothoracic surgery; paediatric empyema; surgery for tuberculosis; mitral valve repair surgery
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES Cooper, D.K.C., Keogh, A.M., Brink, J., Corris, P.A., Kleetko, W., Pierson, R.N., Schmoeckel, M., Shirakura, R. & Warner Stevenson, L. 2000. Report of the xenotransplantation advisory committee of the International Society for Heart and Lung Transplantation: The present status of xenotransplantation and its potential role in the treatment of end-stage cardiac and pulmonary diseases. Journal of Heart and Lung Transplant 19: 1125-1165. Deutsch, M., Meinhart, J., Schense, J., Hubbell, J. & Zilla, P. 2000. Endothelial cell seeding: revisiting the issues. Journal of Vascular Surgery (31):1265-1267. Von Oppell, U.O., Bautz, P. & De Groot, M. 2000. Penetrating thoracic injuries: what we have learnt. Thoracic Cardiovascular Surgeon (48):55-61.
18
Von Oppell, U.O., Stemmet, F., Brink, J., Commerford, P.J. & Heijke, S.A.M. 2000. Ischaemic mitral valve repair surgery. Journal of Heart Valve Disease (9):64-74. Von Oppell, U.O. & Mohr, F. 2000. A new technique that facilitates chordal replacement in minimally invasive mitral valve surgery using premeasured Gore-Tex loops. Ann Thorac Surg 70: 2166- 2168. Weissenstein, C., Human, P., Bezuidenhout, D. & Zilla, P. 2000. Gluteraldehyde detoxification in addition to enhanced amine cross-linking dramatically reduces bioprosthetic tissue calcification in the rat model. Journal of Heart Valve Disease (9):230-240. Zilla, P., Weissenstein, C., Human, P.A., Dower, T. & Von Oppell, U.O. 2000. High gluteraldehyde concentrations mitigate bioprosthetic root calcification in the sheep model. Ann Thorac Surg 70: 2091-2095.
PUBLISHED CONFERENCE PROCEEDINGS
Von Oppell, U.O. 2000. Cardiac surgery in the third world. Pioneering techniques in cardiac surgery: the second in the series. [Invited]. Leipzig, Germany, 20-21. Zilla, P. 2000. Endothelial Seeding NIH/Life-Line Meeting: The Biology of Vascular Interventions – Minimally invasive approaches to Vascular Disease. [Invited]. Bethesda, USA, 1265-2168.
CONFERENCE ABSTRACTS
International: Deutsch, M., Meinhart, J. & Zilla, P. 2000. Clinical in-vitro endothelialization of synthetic blood surfaces: 10 years of experience in 150 vascular patients. VIII Intern Symposium: Cardiac Bioprostheses, Cancun, Mexico. Dower, T. & Zilla, P. 2000. Hypoxic macrophages may promote transmural angiogenesis in the healing of synthetic vascular grafts. VII Bianual Meeting of the Intern. Soc Applied Cardiovasc Biology, Tucson, Arizona. Human, M.P. & Zilla, P. 2000. Characterization of the immune response to valve bioprostheses and its role in primary tissue failure. VIII Intern Symposium: Cardiac Bioprostheses, Cancun, Mexico. Human, P. 2000. Graft-specific antibodyimplicated in calcification of valve bioprosthetic tissue. VII Bianual Meeting of the Intern. Soc Applied Cardiovasc Biology,Tucson, Arizona. Jansen, E. & Von Oppell, U.O. 2000. Multiple vessel grafts (off pump): Live Teleconference demonstration of surgical procedure. Pioneering techniques in cardiac surgery: the second in the series. [Invited live surgery demonstration]. Leipzig, Germany. Meinhart, J., Deutsch, M., Zilla, P., Hubbell, J. & Schense, J. 2000. Enhanced cell retention on endothelialized synthetic vascular grafts by means of RGD crosslinking to fibrin. VII Bianual Meeting of the Intern. Soc Applied Cardiovasc Biology, Tucson, Arizona. Merzkirch, C. & Zilla, P. 2000. Control of vascular cell migration and proliferation by fibronectin and fibronectin fragments. VII Bianual Meeting of the Intern. Soc Applied Cardiovasc Biology, Tucson, Arizona. Smith, J. & Zilla, P. 2000. Cyclic stretch induces the expression of vascular endothelial growth factor in vascular smooth muscle cells: an argument for a compliant vascular graft. VII Bianual Meeting of the Intern. Soc Applied Cardiovasc Biology, Tucson, Arizona. Trantina-Yates, A., Dower, T., Weissenstein, C., Human, P. & Zilla, P. 2000. Stentless bioprosthetic heart valve rresearch: Sheep versus primate model. VIII Intern Symposium: Cardiac Bioprostheses, Cancun, Mexico. Von Oppell, U.O. & Autschbach, R. 2000. Surgical radio frequency ablation of atrial fibrillation: Live Teleconference demonstration of surgical procedure. Pioneering techniques in cardiac surgery: the second in the series. [Invited live surgery demonstration]. Leipzig, Germany. Von Oppell, U.O. 2000. Cardiac surgery in the third world. Pioneering techniques in cardiac surgery: the second in the series. [Invited]. Leipzig, Germany. Von Oppell, U.O. 2000. Cerebral protection in aortic arch surgery. VII International Congress of the Portuguese Society of Cardiothoracic and Vascular Surgery. [Invited]. Tomar, Portugal. Von Oppell, U.O. 2000. Tissue adhesives in cardiovascular surgery. VII International Congress of the Portuguese Society of Cardiothoracic and Vascular Surgery. [Invited]. Tomar, Portugal. Zhang, Y., Human, P., Von Oppell, U. & Zilla, P. 2000. Fixation related tissue damage of commercial stentless aortic valve bioprostheses VIII Intern Symposium: Cardiac Bioprostheses, Cancun. Zilla, P. 2000. Endothelial Seeding NIH/Life-Line Meeting: The Biology of Vascular Interventions – Minimally invasive approaches to Vascular Disease (invited). Bethesda, USA.
19
Zilla, P. 2000. Imunological processes are important in tissue valve failure – Pro. VII Biannual Meeting of the Intern.Soc Applied Cardiovasc Biology (invited), Tucson, Arizona. Zilla, P. 2000. Tissue engineering of prosthetic vascular grafts Invited Key Note Lecture: 49th International Conference of the European Society for Cardiovascular Surgery, Dresden, Germany. Zilla, P. 2000. Graft endothelialization by in vitro lining (invited). XII International Symposium on Atherosclerosis, Stockholm, Sweden. Zilla, P. 2000. Tissue engineering of prosthetic vascular grafts (invited). 32nd Annual Meeting of the Austrian Society for Vascular Surgery, Vienna, Austria.
Local:
Bezuidenhout, D., Weissenstein, C., Human, P., Bracher, M. & Zilla, P. 2000. Cross-link extension with L- Lysine affects aortic wall-, leaflet- and pericardial calcification in the rat model. [Abstract] 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:322. Brink, J.G. 2000. Surgical options in end-stage heart failure. [Invited]. 1st Congress of the South African Heart Association, Stellenbosch. Brink, J.G., du Toit, H., Stemmet, F. & von Oppell, U. 2000. The minimally invasive approach to the aortic valve - the University of Cape Town experience. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:277. Brink, J.G., Moore, K., Seele, K., Church, H., Hewitson, J. & von Oppell, U. 2000. Heart transplantation at Groote Schuur Hospital - a comparison with international trends in thoracic organ transplantation. [Abstract]. 1st Congress of the South African Heart Association. Stellenbosch, Cardiovascular Journal of South Africa 11:314. Davies, N., Dower, T. & Zilla, P. 2000. Control of vascular cell migration and proliferation by fibronectin and fibronectin fragments. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:322-323. Davies, N., Dower, T. & Zilla, P. 2000. Hypoxic macrophages may promote transmural angiogenesis in the healing of synthetic vascular grafts. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:323. De Groot, K.M. 2000. Surgical approach for the solitary pulmonary nodule. [Invited]. Combined Congress of Critical Care & Pulmonology Societies of South Africa, Durban. De Groot, K.M. 2000. Use of stents in thoracic surgery. [Invited]. Combined Congress of Critical Care & Pulmonology Societies of South Africa, Durban. Deutsch, M., Meinhart, J. & Zilla, P. 2000. Clinical in-vitro endothelialization of synthetic blood surfaces: 10 years of experience in 150 vascular patients. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:288. Du Toit, H., Stemmet, F., von Oppell, U.O. & Brink, J.G. 2000. Stentless aortic valves: Biocor no-react versus MedtroniFreestyle® valves - short-term results. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:315. Hewitson, J., Lawrenson, J. & Stirling, J. 2000. Minimally invasive approach to repair of atrial septal defects. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:289. Human, P. & Zilla, P. 2000. Characterization of the immune response to valve bioprostheses and its role in primary tissue failure. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:284-286. Human, P., Weissenstein, C., Trantina, A. & Zilla, P. 2000. Immediate tissue fixation significantly reduces the calcification of aortic wall tissue. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11: 321. Karani, Z., Hewitson, J.P. & von Oppell, U. 2000. Comparative analysis of VSD closure techniques. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:319-320. Kowolik, H., von Oppell, U.O. & Stemmet, F. 2000. Blunt traumatic aortic rupture: recommended techniques based on a 15-year experience. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:318. Moore, K., Seele, K., Stemmet, F. & Brink, J.G. 2000. Review of opportunistic infections in heart transplant recipients over an eight year period. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:313.
20
Prager, M., Kilinska, L., Dower, T., Trantina, A. & Zilla, P. 2000. Insufficient tissue crosslinking enhances potentially detrimental transanastomotic pannus ingrowth in stentless bioprosthetic heart valves. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:316. Smith, J., Davies, N., Dower, T., Sumpio, B. & Zilla, P. 2000. Cyclic stretch induces the expression of vascular endothelial growth factor in vascular smooth muscle cells: And argument for a compliant vascular graft. [Abstract]. 1st Congress of the South African Heart Association. Stellenbosch. Cardiovascular Journal of South Africa 11:284. Trantina-Yates, A.E., Zilla, P. & Rigler, B. 2000. Endothelialization of bioprosthetic heart valves reduces calcification and inflammatio. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:318. Trantina-Yates, A.E. & Zilla, P. 2000. Stentless bioprosthetic heart valve research: sheep versus primate model. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:318-319. Von Oppell, U.O. 2000. Timing of revascularization after myocardial infarction. [Invited]. 1st Congress of the South African Heart Association, Stellenbosch. Von Oppell, U.O., Kowolik, H. & Scott Millar, R.N. 2000. The surgical treatment of arrhythmia’s. [Invited]. 1st Congress of the South African Heart Association, Stellenbosch. Von Oppell, U.O. & Mohr, F. 2000. A new technique that facilitates chordal replacement in both minimally invasive and conventional mitral valve surgery using premeasured Gore-tex loops. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:317-318. Von Oppell, U.O., Stemmet, F., Brink, J., Commerford, P. & Heijke, S. 2000. Ischaemic mitral valve repair surgery. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:276. Von Oppell, U.O., Stemmet, F., Oliver, S., Roditi, D. & Brink, J. 2000. Infective endocarditis: the diagnostic and therapautic implications of operative findings. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:275- 276. Weissenstein, C., Human, P., Bezuidenhout, D. & Zilla, P. 2000. Gluteraldehyde detoxification on top of enhanced cross-linking dramatically reduces bioprosthetic tissue calcification in the rat model. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:322. Worthington, M., Brink, J.G, Moore, K., Seele, K., Hewitson, J. & von Oppell, U. 2000. Cardiac transplantation cardioplegia St Thomas No2 vs. Bretschneider HTK4. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:314. Zhang, Y., Human, P., von Oppell, U. & Zilla, P. 2000. Fixation-related tissue damage of commercial stentless valve bioprostheses. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:319. Zilla, P. 2000. Tissue engineering of cardiovascular prostheses. [Invited]. 1st Congress of the South African Heart Association, Stellenbosch. Zilla, P., Weissenstein, C., Human, P. & Bracher, M. 2000. The anticalcification effect of gluteraldehyde detoxification on aortic wall tissue in the sheep model. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:286. Zilla, P., Weissenstein, C., Human, P. & von Oppell, U. 2000. Aortic root prostheses in the sheep model: mitigation of wall calcification through increased gluteraldehyde crosslinks. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:321-322. Zilla, P., Weissenstein, C., Human, P., Bezuidenhout & van der Walt, A. 2000. L-Lysine extension of gluteraldehyde crosslinks further enhances their mitigating effect on porcine aortic wall calcification in the sheep model. [Abstract]. 1st Congress of the South African Heart Association, Stellenbosch. Cardiovascular Journal of South Africa 11:316.
EDUCATIONAL COURSES
De Groot, K.M. 2000. The solitary pulmonary nodule. Local CPD course; Southern Cross Hospital, Cape Town. [Invited].
21
Von Oppell, U.O. 2000. Current issues in valve surgery. Cape Town cardiothoracic surgeons; Panorama Hospital, Cape Town. Klein Panarama Guest House. [Invited]. Von Oppell, U.O. 2000. Mitral valve disease and atrial fibrillation: solutions to this ongoing global problem. Department of Cardiology, University College Hospital, London. [Invited]. Von Oppell, U.O. 2000. Mitral valve surgery: current issues. The New Jersey Chapter of the College of Surgeons Travellers Club. University of Cape Town, Medical School. [Invited]. Von Oppell, U.O. 2000. Principles of myocardial protection during cardiopulmonary bypass. Anaesthetic refresher course, Medical school, University of Cape Town. [Invited]. Von Oppell, U.O. 2000. Robotic Surgery in the new millennium. Grand Rounds. Medical Faculty, University of Cape Town. Von Oppell, U.O. 2000. Surgery for atrial fibrillation. Cape Town cardiologists & cardiothoracic surgeons, Cullinen Hotel, Cape Town. [Invited]. Von Oppell, U.O. 2000. Surgery for atrial fibrillation. Johannesburg cardiologists & cardiothoracic surgeons, Morningside Clinic, Johannesburg. [Invited].
THESES AND DISSERTATIONS PASSED FOR HIGHER DEGRESS
Walther, G. 2000. Lung volume reduction surgery: the Groote Schuur Hospital Experience, University of Cape Town. M.Med dissertation, University of Cape Town. Williams, E. 2000. FCS (SA) Cardiothoracic Surgery. University of Cape Town.
CONSULTANCY AND OTHER ACTIVITIES BASED ON EXPERTISE DEVELOPED IN RESEARCH
Brink, J.G. 2000. Member of Xenotransplantation advisory committee; International Society of Heart and Lung Transplanation. Von Oppell, U.O. 2000. Editorial Board; Cardiovascular Journal of South Africa Zilla, P. 2000. Co-ordination: Intern Clinical Multi-Centre Study: In-Vitro Endothelialization of Vascular Grafts (12 Centres). Zilla, P. 2000. Editorial Board; Cardiovascular Pathology. Zilla, P. 2000. Advisory Board; Advanced Tissue Sciences, San Diego, USA. Zilla, P. 2000. Editor; Circulator.
22
DEPARTMENT OF CHEMICAL PATHOLOGY (Including the Chemical Pathology sections of Groote Schuur Hospital and Red Cross War Memorial Childrens’ Hospital)
HEAD OF DEPARTMENT - Professor J.S. Davidson
DEPARTMENTAL CONTACT DETAILS Postal address: Department of Chemical Pathology University of Cape Town Medical School Observatory 7925 South Africa Telephone : SA (21) 406-6185 Fax : SA (21) 448-8150 e-mail : [email protected]
DEPARTMENTAL PROFILE
Associate Professor David McIntosh’s research group has developed ATP analogues as specific probes of the ATP site of the P-glycoprotein, which is responsible for drug resistance of cancer cells. These analogues will be used in the design of more potent inhibitors, with the ultimate goal of enhancing cancer chemotherapy. Professor McIntosh's reputation as a leader of his field was highlighted when he was invited to critically appraise new developments on the calcium pump in a review for News and Views, Nature Structural Biology. Associate Professor Daan Steenkamp made outstanding advances towards identifying the enzymes of novel biochemical pathways of thiol metabolism in the TB bacillus and in trypanosomes (sleeping sickness). His success was recognised by the award of a large grant from the Wellcome Trust. The holy grail of new anti-TB and anti-trypanosome drugs seems closer than ever! Professor Eric Harley's group has identified a novel method of free radical removal involving dityrosine which exists in the rhinoceros, and may be of relevance to human disease. His group has made DNA libraries from bats and sharks for population genetic studies which are vital for conservation strategies. Professor James Davidson, together with Associate Prof. Brian Rayner of the Dept. of Medicine, reported a high prevalence of primary aldosteronism and low-renin hypertension in Black patients. They also found low renin and aldosterone levels in Black normotensives, suggesting a salt-retaining tendency in this population group which may be relevant to hypertension. Dr Peter Berman perfected a method for determining carbohydrate-deficient transferrin as a marker of alcohol abuse.
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG TERM CONTRACT STAFF STUDENTS
Professors 2 Doctoral 11 Associate Professors 4 Masters 2 Emeritus Professors 1 M Med 3 Medical Natural Scientists 4 Honours 2 Medical Specialists 2 Undergraduate 172 Research Officers 2 TOTAL 190 Research Assistants 4 Administrative and Secretarial Staff 2 Technical Officers 1 Departmental Assistants 3 TOTAL 25
23
RESEARCH FIELDS
Professor J.S. Davidson Hypertension; renin; aldosterone, Aldosterone disorders Associate Professor D.B. McIntosh P-type ATPase; calcium-ATPase; multidrug resistance P-glycoprotein; flavonoids; site-directed mutagenesis; photoaffinity labelling; Ion Pumps and ABC transporters: Mechanism and drug targeting of ion pumps and ABC transporters of Mycobacterium tuberculosis and mammals; Properties and drug targeting of hypoxanthine phosphoribosyl transferase from malaria and Toxoplasma gonidii Emeritus Professor M.C. Berman Calcium metabolism in muscle; calcium-ATPase pump mechanism; coupling and uncoupling of calcium transport; Ion Pumps and ABC transporters: Mechanism and drug targeting of ion pumps and ABC transporters of Mycobacterium tuberculosis and mammals; Properties and drug targeting of hypoxanthine phosphoribosyl transferase from malaria and Toxoplasma gonidii Professor E.H. Harley Inherited metabolic disease; homocysteinaemia; mitochondrial myopathy; red cell metabolism; population genetics; molecular evolution; molecular systematics Inherited Metabolic Disorders/Molecular Evolution. (1) Mitochondrial DNA diseases (2) Molecular genetics of inherited metabolic disorders (3) DNA analysis as a tool for molecular systematics and population genetics Dr E.P. Owen Homocysteine; mitochondrial DNA mutations; TPMT mutations; urea cycle disorders Inherited Metabolic Disorders/Molecular Evolution. (1) Mitochondrial DNA diseases (2) Molecular genetics of inherited metabolic disorders (3) DNA analysis as a tool for molecular systematics and population genetics Dr D. Steenkamp Thiol metabolism in pathogens; Biochemical Parasitology Enzymes in the metabolism of the trypanosomatids and mycobacteria as potential drug targets Dr P. Berman Carbohydrate-deficient transferrin as a biochemical marker of alcoholism. Biochemstry of Alcoholism Dr J.A. King Evolution of gonadotropin-releasing hormones and their receptors; Molecular Reproductive Endocrinology Associate Professor L.R. Purves Mass spectrometry; gastrointestinal function. Biochemical Diagnosis of Diseases of Sick Children (Red Cross War Memorial Childrens’ Hospital) (1) Gastrointestinal function (2) Genetics of hyperlipidaemia, tuberculosis, galactosaemia, and cystic fibrosis (3) Mass spectrometry (4) Inherited metabolic disease Associate Professor H. Henderson Genetics of hyperlipidaemia, galactosaemia, and cystic fibrosis; inherited metabolic disease; Biochemical Diagnosis of Diseases of Sick Children (Red Cross War Memorial Childrens’ Hospital) (1) Gastrointestinal function (2) Genetics of hyperlipidaemia, tuberculosis, galactosaemia, and cystic fibrosis (3) Mass spectrometry (4) Inherited metabolic disease Ms F. Leisegang Genetics of galactosaemia and cystic fibrosis; application of PCR to genetic screening; Biochemical Diagnosis of Diseases of Sick Childre (Red Cross War Memorial Childrens’ Hospital) (1) Gastrointestinal function (2) Genetics of hyperlipidaemia, tuberculosis, galactosaemia, and cystic fibrosis (3) Mass spectrometry (4) Inherited metabolic disease
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Berman, M.C. 2000. Characterisation of thapsigargin-releasable Ca2 from the Ca2+ -ATPase of sacroplasmic reticulum at limiting [Ca2+]. Biochemica et Biophysica Acta 1509: 42-54.
24
Berman, C. & Brandt, W.F. 2000. Existence of covalently cross-lonked haemoglobin in human erythrocytes, and its induction by naturally occurring sugars in vitro. South African Journal of Science 96: 549. Champeil, P., Henao, F., Lacapere, J.J. & McIntosh, D.B. 2000. A remarkably stable phosphorylated form of Ca2+-ATPase prepared from Ca2+-loaded and fluorescein-isothiocyanate-labelled sarcoplasmic reticulum vesicles. Journal of Biological Chemistry. Clee, S.M., Bissada, N., Miao, F., Miao, L., Marais, A.D., Henderson, H.E., Steures, P., McManus, J., McManus, B., LeBoeuf, R.C., Kastelein, J.J. & Hayden, M.R. 2000. Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis. Journal of Lipid Research 41: 521-531. Forlano, P.M., Maruska, K.P., Sower, S.A., King, J.A. & Tricas, T.C. 2000. Differential distribution of gonadotropin-releasing hormone-immunoreactive neurons in the stingray brain: functional and evolutionary considerations. General and Comparative Endocrinology 118: 226-248. Ginzinger, D.G., Clee, S.M., Dallongeville, J., Lewis, M. E., Henderson, H.E., Bauje, E., Rogers, Q.R., Jensen, D.R., Eckel, R.H., Dyer, R., Innis, S., Jones, B., Fruchart, J.C. & Hayden, M.R. 1999. Lipid and lipoprotein analysis of cats with lipoprotein lipase deficiency. European Journal of Clinical Investigation 29: 17-26. Harley, E.H., Baumgarten, I. & Rogers, P.S. 2000. The use of DNA microsatellite markers for determining paternity in a captive cheetah population. South African Journal of Wildlife 30: 22- 25. King, J.A., Fidler, A., Lawrence, S., Adam, T., Millar, R. & Katz, A. 2000. Cloning and expression, pharmacological characterization, and internalization kinetics of the pituitary GnRH receptor in a metatherian species of mammal. General and comparative endocrinology 117: 439-448. McIntosh, D.B. 2000. Portrait of a P-type pump. Nature Structural Biology 7: 532-535. Pienaar, S., Eley, B., Beatty, D.W. & Henderson, H.E. 2000. X-linked agammaglobulinaemia and the underlying genetics in two kindreds. Journal of Paediatric Child Health 36: 453-456. Rayner, B.L., Opie, L.H. & Davidson, J.S. 2000. Aldosterone/renin ratio as a screening test for primary aldosteronism. South African Medical Journal 90: 394-400. Soule, S.J., Davidson, J.S. & Rayner, B.L. 2000. The evaluation of primary aldosteronism. South African Medical Journal 90: 387-394. Wiseman, R., O’Ryan, C. & Harley, E.H. 2000. Microsatellite analysis reveals that domestic cat (Felis catus) and southern African wild cat (F.lybica) are genetically distinct. Animal Conservation 3: 221-228.
CONFERENCE ABSTRACTS
Anderson, S., Yekeso, N., Goliath, R., Pienaar, S., Wood, K., Eley, B., Henderson, H.E., Hussey, G., Iloni, K., Hughes, J., Beatty, D. & Levin, M. 2000. Childhood tuberculosis: a functional approach towards the identifcation of mutations and polymorphisms in genes controlling the interferon gamma pathway. Institute of Child Health and Department of Chemical Pathology Research Day, Red Cross Childrens’ Hospital, Rondebosch, South Africa. Bellstedt, D.U., Linder, H.P. & Harley, E.H. 2000. Phylogenetic relationships in the Disinae based on non-coding trnL-trnF chloroplast sequences: evidence of numerous repeat regions. South African Society of Systematic Biology 2nd Conference, Mtunzini, South Africa. Bellstedt, D.U., Linder, H.P. & Harley, E.H. 2000. Phylogenetic relationships in the Disinae based on non-coding trnl-trnF chloroplast sequences: evidence of numerous repeat regions. Meeting of the Association for the Study of the Taxonomy of Tropical African Plants, Brussels, Belgium. Berman, P.A. 2000. Underglycosylated transferrin as a biochemical marker of excessive alcohol exposure. UCT Pathology Research Day, University of Cape Town Medical School, Observatory, South Africa. Berman, P.A., Baumgarten, I., Kramer, Y. & Anthony, J. 2000. Elevated serum urate as a marker of pre-eclampsia: evidence for impaired renal tubular urate secretion. Department of Obstetrics and Gynaecology Research Day, UCT Medical School, Observatory, South Africa. Blignaut, A., Morley, A.J., Burger, W.P., Harley, E.H. & Bellstedt, D.U. 2000. Phylogenetic relationships of ostrich mycoplasmas based on 16srRNA sequences. South African Society of Systematic Biology 2nd Conference, Mtunzini, South Africa. Clee, S., Bissada, N., Miao, F., Miao, L., Marais A.D., Henderson, H.E., Steures, P., Mcmanus, J., Mcmanus, B. & Hayden, M. 1999. Atherogenicity of lipoprotein lipase is related to its site of expression in mice: circulation vs vessel wall. South African Association of Clinical Biochemists FSASP Congress, Durban, South Africa.
25
Daskiewicz, J.B., Comte, G., Bayet, C., Barron, D., Viornery, A., Dumontet, C., Conseil, G., de Wet, H., McIntosh, D. & Di Pietro, A. 2000. Flavanoidic modulators of P-glycoprotein: positive effect of hydrophobic substitutions on rings A and B, and of opening of ring C. Polyphenols Communications 2000, Freising-Weihenstephan, Germany. Davidson, J.S., Opie, I.H., Myers, J., Trinder, V.A. & Rayner, B.L. 2000. Screening for primary aldosteronism: normal ranges for aldosterone and renin in three South African population groups. UCT Pathology Research Day, University of Cape Town Medical School, Observatory, South Africa. Eick, G., Harley, E.H. & O’Ryan, C. 2000. The use of microsatellites to test the hypothesis of kin selection in a eusocial insect, Camponotus klugii. Experimental Biology Meeting. University of Cape Town, Rondebosch, South Africa. Harley, E.H. 2000. The University of Cape Town (UCT) wildlife cell bank: uses in conservation genetics. Genetic Resources for the New Century, San Diego, USA. Harley, E.H. & Weber, B. 2000. Insights into free radical pathology from studies in comparative red cell metabolism. UCT Pathology Research Day, University of Cape Town Medical School, Observatory, South Africa. Henderson, H.E., Clee, S., Ratangee, B., Hayden, M.R. & Marais, A.D. 2000. The use of gradient gel electrophoresis to investigate lipoprotein particle size variation in ApoE knockout mice, expressing varying levels of lipoprotein lipase. UCT Pathology Research Day, University of Cape Town Medical School, Observatory, South Africa. Henderson, H., Leisegang, F., Hayden, M. & Marais, A. 2000. Lipoprotein lipase gene defects are common in pregnancy-induced hypertriglyceridemic pancreatitis. South African Association of Clinical Biochemists FSASP Congress, Durban, South Africa. Henderson, H., Leisegang, F. & Reynolds, L. 2000. DNA analysis of spinal muscular atrophy in the Western Cape. Federation of the South African Society of Pathology Annual Congress, Warmbaths, South Africa. Hislop, H., Madziva, M., Everest, H., Harding, T., Uney, J., Millar, R., Troskie, B., Davidson, J.S., Willars, G.B. & McArdle, C.A. 2000. Differential desensitization and internalization of human and Xenopus gonadotropin-releasing hormone receptors expressed in pituitary cells using recombinant adenovirus. The Endocrine Society 82nd Annual Meeting, Toronto, Canada. McIntosh, D.B., de Wet, H., Seekoe, T., Di Pietro, A., Callaghan, R. & Goffeau, A. 2000. Mechanism and drug targeting of multidrug resistance P-glycoprotein. UCT Pathology Research Day, University of Cape Town Medical School, Observatory, South Africa. Miller-Butterworth, C.M., Jacobs, D.S. & Harley, E.H. 2000. Population genetics of Schreibers’ long- fingered bat, Miniopterus schreibersii in South Africa. North American Bat Research Symposium, Miami, USA. Rayner, B.L. & Davidson, J.S. 2000. The efficacy of the AT1 receptor antagonist in low renin hypertension: a preliminary report. Angiotensin II College, Limerick, Ireland. Riordan, G. & Owen, P. 2000. Leigh syndrome: a novel mutation. Institute of Child Health and Department of Chemical Pathology Research Day, Red Cross Childrens’ Hospital, Rondebosch, South Africa. Shaboodien, G., Eley, B., Hughes, J. & Henderson, H. 2000. Molecular analysis of x-linked severe combined immuno-deficiency and atypical phenotypes. UCT Pathology Research Day, University of Cape Town Medical School, Observatory, South Africa. Shaboodien, G., Eley, B., Hughes, J. & Henderson, H. 2000. Gene mutational analysis of Severe Combined Immunodificiency. Institute of Child Health and Department of Chemical Pathology Research Day, Red Cross Childrens’ Hospital, Rondebosch, South Africa. Swarts, L., Owen, P., Delport, S. & Henderson, H. 2000. DNA analysis of ornithine transcarbamylase deficiency. UCT Pathology Research Day, University of Cape Town Medical School, Observatory, South Africa. Swarts, L., Owen, P., Delport, S. & Henderson, H. 2000. Molecular genetics of ornithine transcarbamylase deficiency in South African subjects. Institute of Child Health and Department of Chemical Pathology Research Day, Red Cross Childrens’ Hospital, Rondebosch, South Africa. Van der Merwe, A., Marais, E.M., Harley, E.H. & Bellstedt, D.U. 2000. Phylogenetic relationships in the minor genera of the Hyacinthaceae based on non-coding trnL-trnF chloroplast sequences. South African Society of Systematic Biology 2nd Conference, Mtunzini, South Africa. Vogt, R. & Steenkamp, D. 2000. A novel transsulfuration reaction: the biosynthesis of ovothiol A in the Leishmania parasites. UCT Pathology Research Day, University of Cape Town Medical School, Observatory, South Africa.
26
THESES AND DISSERTATIONS PASSED FOR HIGHER DEGREES
De Wet, H. 2000. The nucleotide binding domains of multidrug resistance P-glycoproteins. Ph.D. thesis, University of Cape Town. Henshall-Howard, M-P.A.E. 2000. An investigation of the role of N102 of the GnRH receptor in determining the potency of C-terminally modified agonist analogs. M.Sc. dissertation, University of Cape Town. Weber, B. 2000. Red blood cell pathophysiology: comparative and diagnostic aspects. Ph.D. thesis, University of Cape Town.
27
DEPARTMENT OF DERMATOLOGY
HEAD OF DEPARTMENT - Professor Gail Todd
DEPARTMENTAL CONTACT DETAILS Postal address: Department of Dermatology Ward G23 Groote Schuur Hospital Observatory 7925 South Africa Telephone: SA (21) 404-3376 Fax: SA (21) 47-8232 e-mail : [email protected]
DEPARTMENTAL PROFILE
Despite the staffing crisis at a time of significant faculty reforms, the Department of Dermatology continues to maintain a high academic profile, meeting its many teaching, services and research commitments. This is possible because of a dedicated staff and ongoing interdisciplinary research and service links with a number of other departments both nationally and internationally. With the help of the Development Office, funding for the UCT Skin & Hair Centre at the UCT Lung Institute was raised. The Centre has facilities for managing patients with skin disease on an outpatient basis and aims to complement colleagues in private practice by offering a specialist referral service. Funds generated in the Centre are to be used to finance departmental activities. The Centre provides the space essential for clinical and applied research. Professor Norma Saxe retired this year but remains an active honorary member of the department. Dr Sue Jessop was appointed as a full-time senior lecturer and her experience and capable contributions to the department have been invaluable. Dr Pat Lawrence continues to develop the paediatric dermatology service at Red Cross Hospital, the first of its kind in Southern Africa. A diploma course in this sub-speciality is planned for the future.
The Dermatology Nurse’s Diploma Course, run in collaboration with the Nursing Education Unit at Groote Schuur Hospital, continues to train nurses from all over Southern Africa. Nurses are taught basic dermatology diagnosis and management to enable them to run community based day-care centres. Functional units in South Africa operate at Wesfleur (Atlantis) and Hout Bay and are run by dermatology nurse graduates. Similar units are now established in Zimbabwe. The course has been listed by the International Federation of Anti-Leprosy Associations and several nurses from throughout Africa are to be sponsored by The Leprosy Mission International and South Africa in 2001. Rotary has adopted the concept for its Rotary Road to Skin Health campaign. Local and international funding has been raised to sponsor clinic development and the training of nurses in under-serviced areas. CPN Pat Kelly, one of the graduates is funded by departmental research money to co-ordinate the initiative. She represents South Africa and Africa on the International Skin-Care Nursing Group, a recently constituted organisation that aims to promote the provision of skin care internationally.
A collaborative project with Professor Hywel Williams, University of Nottingham, funded by a 3-year Wellcome Grant on the prevalence and cost of childhood atopic dermatitis in rural, urban and informal settlements in around Cape Town, South Africa was initiated this year. The fieldwork is to be completed early in 2001. Dr Sue Jessop has completed a Cochrane systematic review in collaboration with the University of Stellenbosch and the Cochrane Skin Group, Nottingham on treatments for chronic discoid lupus erythematosus. The National Occupational Skin Disease Initiative, a national collaborative project run under the auspices of the South African Society of Occupational Medicine, is co-ordinated through the Department because of its status as a centre of expertise in occupational skin diseases and contact dermatitis.
28
Beach clinics, voluntarily run by local dermatologists to publicise the dangers of sunlight with regard to skin cancer took place over December 1999 and January 2000 in collaboration with the Cancer Association of South Africa and Rotary. They continue to be co-ordinated by Dr Cecile Keyzer. Local collaborative research includes a project on ethno-pharmacology investigations into traditional plants together with the Pharmacology Department, an investigation on the molecular basis of vitiligo with the Department of Anatomy and Cell Biology, projects on industry related skin disorders with the Department of Community Health, a study of skin diseases in children with chronic diarrhoea with the Department of Paediatrics and studies on aspects of lupus and scleroderma with the Rheumatic Diseases Unit. The Department’s training programme includes teaching of undergraduate medical students, (3rd to 6th year), nurses and students in professions allied to medicine. Several foreign students have worked in the department during 2000. Postgraduate students include 3 dermatology registrars. The department contributes to continuing professional development all year round, lecturing to various healthcare providers and participating in many refresher courses and educational initiatives.
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG TERM STUDENTS CONTRACT STAFF Associate Professors 1 Doctoral 1 Senior Lecturer (full-time) 1 Masters 4 Senior Lecturers (part-time 5/8) 1 Undergraduate 680 (part-time, sessional) 6 TOTAL 685 Research Staff 3 Administrative and clerical staff 2 Honorary Snr Lecturer 3 TOTAL 17
RESEARCH FIELDS
PERMANENT STAFF
Associate Professor Gail Todd Head of Department; Prevalence and cost of childhood atopic dermatitis in rural, urban and periurban settlements around Cape Town, South Africa, collaborative project with the University of Nottingham; Occupational dermatoses amongst seafood workers and occupational allergy associated with rock lobster and salt water bony fish processing in South Africa, collaborative projects with the Department of Community Health and University of Michigan, USA; Patch testing and atopic eczema, collaborative study Dermatology Departments in UK, Tanzania and South Africa; the molecular basis of vitiligo and its treatment (Dr Gavin Gottschalk, MRC scholarship) Department of Anatomy and Cell Biology; Study to identify indigenous plants with antiviral therapeutic potential and isolation of active ingredients; (Miss Sibongile Pefile PhD student) Department of Pharmacology Dr Susan Jessop Risk and benefits of oestrogen therapy in systemic lupus erythematosus, collaborative study with Departments of Obstetrics and Gynaecology and Rheumatic Diseases Units, University of Cape Town and Stellenbosch, the use of functional measures in systemic sclerosis in collaboration Department of Rheumatic Diseases; Cochrane review: Treatments for discoid lupus erythematosus in collaboration with the Departments of Dermatology and Rheumatic Diseases Unit, University of Stellenbosch and The Cochrane Skin Group, Nottingham Dr Pat Lawrence Skin lesions in children with chronic diarrhoea, collaborative study with Department of Paediatrics
29
HONORARY STAFF (LECTURERS)
Professor Norma Saxe Dr M. Forder Dr I. Webster CPN Nora Christians
REGISTRARS
Dr J. Milne Management of vitiligo with khellin and ultraviolet radiation Dr G. Sobey Inpatient treatment of chronic plaque psoriasis Dr A. Collison
RESEARCHERS
S. Tolosana (research assistant – full-time) Prevalence and cost of childhood atopic dermatitis in rural, urban and informal settlements around Cape Town, South Africa, collaborative project with the University of Nottingham (Wellcome grant) P. Kelly (senior sister – part-time) Delivery of primary and secondary dermatological care; the role of the dermatology nurse and the establishment of community dermatology day-care centres S. Pefile (in collaboration) PhD student, Department of Pharmacology; The use of traditional medicinal plants in the treatment of viral skin disorders G. Gottschalk (MRC scholarship – in collaboration) MSc student, Department of Anatomy and Cell Biology; A molecular analysis of vitiligo lesional melanocytes and of the possible involvement of the Sonic Hedgehog (SHH) signalling pathway in aetiopathogenesis (MRC grant) S Copelyn (research assistant – part-time) Cancer and vitiligo (MRC grant)
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
McKenzie, R. & Roux, P. 2000. Disseminated BCG infection following bone marrow transplantation for X-linked severe combined immunology. Paediatric Dermatology 17(3):208-212.
CONGRESS ABSTRACTS
Jessop, S., Whitelaw, D. & Jordaan, F. 2000. Drug treatments for discoid lupus erythematosus. 8th International Cochrane Colloquium Abstracts.
UNIVERSITY PUBLICATIONS AND PUBLICATIONS OF A POPULAR NATURE
Benjamin, E.S. 2000. Itching and scratching in the elderly. Continuing Medical Education 18: 521. Docrat, E. 2000. Bullous pemphigoid,. Current Allergy and Clinical Immunology 12(2): 36. Jessop, S. 2000. Itching and scratching. An approach to diagnosis and management. Continuing Medical Education 18: 483. Lawrence, P. 2000. Itching and scratching. Inflammatory skin disease. Continuing Medical Education 18:502. McKenzie, R. 2000. Itching and scratching. HIV disease. Continuing Medical Education 18: 528. Saxe, N. 2000. Itching and scratching. Itch as metaphor. Continuing Medical Education 18: 480. Todd, G. 2000. Itching and scratching. Continuing Medical Education 18: 478. (Guest editor and Editorial) Todd, G. 2000. .Dermatologics, South African Medicines Formulary 5th Edition, 2000.
30
Todd, G. 2000. The role of the dermatologist in the diagnosis and management of allergic skin conditions.Allergy Abstracts No 10.
CONSULTANCY AND OTHER ACTIVITIES
Members of the department act as consultants and serve on many committees at local, national and international level in addition to their routine commitments. This ensures that our dermatology service continues to function at a high standard and that dermatology, as a speciality, is not marginalised during health reforms. We intend expanding the clinical drug trials with which we have been actively involved to generate funds necessary for dermatology teaching, research and services to be sustained and developed in the future. In order to increase skin care at a primary care level we are planning to introduce diplomas in dermatology and paediatric dermatology in 2001. This will be a first in Southern Africa and will be available to the region as a whole, as is our Dermatology Nurse Diploma Course.
31
DEPARTMENT OF FORENSIC MEDICINE AND TOXICOLOGY
HEAD OF DEPARTMENT - Professor G. J. Knobel
DEPARTMENTAL CONTACT DETAILS
Postal Address: Department Forensic Medicine & Toxicology Faculty of Health Sciences Anzio Road Observatory 7925 Telephone: SA (21) 406-6412 Fax: SA (21) 448-1249 E-Mail: [email protected]
DEPARTMENTAL PROFILE
A range of activities related to the role of Forensic Medicine in public policy and health promotion are being pursued. The provision of a sustainable database on violence and injury in the Cape Town Metropole is being implemented as an urgent research priority.
DEPARTMENTAL STATISTICS 2000
PERMANENT STAFF STUDENTS
Chief Specialist/Professor 1 Undergraduate third year 185 Specialists 2 Undergraduate fourth year 167 Registrars 2 Final year LLB students 23 Principal Medical Officer (part-time) 1 (Medicina Forensis course) Chief Medical Technologist 1 TOTAL 375 Administrative and clerical 4
TOTAL 11
RESEARCH FIELDS
PERMANENT STAFF
Professor G. J. Knobel Head of Department; Cape Town injury mortality database: an ongoing departmental project with the Cape Town Metropolitan Non-natural Mortality Study Group and the Health Consulting Office, Health Technology Research Group, Medical Research Council, aimed at reporting the epidemiology of all non-natural mortality in the Cape Town area as a basis for a local injury control policy; S. A. Community Epidemiology Network on Drug Use: alcohol and unnatural deaths; epidemiology of homicidal firearm injuries for the period 1994 to 2000; epidemiology of violent and unnatural deaths in the greater Cape Town area; Statutory, legal and ethical issues in HIV/AIDS; deaths related to recreational drugs; hazards of intravenous fluid administration to Neonates: Intravenous Fluid Investigative Task Team, Dept. Pharmacology, Groote Schuur Hospital Dr D. Lourens Specialist; survival rate in pericardial injuries - in conjunction with the Trauma Unit of Groote Schuur Hospital; death in custody, sexual asphyxia’s
32
Dr L.J. Martin Specialist; Medical Research Council - Crime Violence and Injury Lead Programme; sustainable solutions for women and children with HIV/AIDS; South African Gender-Based Violence and Health Initiative; National study of the epidemiology of female murder; International Initiative on Sexual Violence; National rape training task team; Rape Prevention Strategy Project Dr L. Liebenberg Registrar; the survival rate in pericardial injuries; in conjunction with the Trauma Unit of Groote Schuur Hospital; Firearm fatalities and final judicial outcome
RESEARCH OUTPUTS
CONFERENCE ABSTRACTS
Knobel, G.J. 2000. The legal System in South Africa. District Surgeons Seminar, Bredasdorp. Knobel, G.J. 2000. Statutory Obligations of Doctors in South Africa. District Surgeons Seminar, Bredasdorp. Knobel, G.J. 2000. Causes of Death and Death Certification. District Surgeons Seminar, Bredasdorp. Knobel, G.J. 2000. The doctor’s responsibility in Child Abuse and Elder Neglect and abuse. District Surgeons Seminar, Bredasdorp. Knobel, G.J. 2000. The Skull of Hintsa?? Research Day 2000, Division of Pathology, Cape Town. Knobel, G.J. 2000. Medico-legal and Ethical Issues of HIV/AIDS. AIDS 2000 Conference, Bellville. Knobel, G.J. 2000. The Doctor and the Law; Medico-legal and Ethical Issues in Modern Family Practice. SA Academy of Family Practice, HPC Offices, Cape Town. Knobel, G.J. 2000. The Health Professional and the Law. 2 Military Hospital, Wynberg. Knobel, G.J. 2000. Alcohol and Unnatural Deaths in Cape Town; 1994 – 1998. Congress of the International Society of Pathologists: PATH 2000, Warmbaths. Knobel, G.J. 2000. Fulminant Liver Necrosis: Hepato-toxin or Infection. Congress of the International Society of Pathologists: PATH 2000, Warmbaths. Knobel, G.J. 2000. Embalmed Witness: The Human Tissue Act and relationship to the Inquest Act. Congress of the International Society of Pathologists: PATH 2000, Warmbaths. Knobel, G.J. 2000. Myospherulosis: Fungal Infection or artefact. Congress of the International Society of Pathologists: PATH 2000, Warmbaths. Knobel, G.J. 2000. Monday Morning Angina due to Withdrawal From Trinitro-Glycerine exposed to in Explosives Factory: Discussion of three cases. Congress of the International Society of Pathologists: PATH 2000, Warmbaths. Knobel, G.J. 2000. Excessively High Carbon Monoxide Level in Firearm Suicide. Congress of the International Society of Pathologists: PATH 2000, Warmbaths.. Knobel, G.J. 2000. Elder Abuse: Elder Amendment Act and the Statutory Obligation of the Health Care Worker. Congress of the International Society of Pathologists: PATH 2000, Warmbaths. Knobel, G.J. 2000. Death from “Severe Headache”; Presentation of two interesting cases. Congress of the International Society of Pathologists: PATH 2000, Warmbaths. Knobel, G.J. 2000. Hintsa’s Head or Phantom Skull? (Poster presentation). Congress of the International Society of Pathologists: PATH 2000, Warmbaths. Martin, L.J. 2000. Forensic management of rape. District Surgeons Seminar, Breadsdorp. Martin, L.J. 2000. Collection of biological evidence. District Surgeons Seminar, Bredasdorp. Martin, L.J. 2000. Effects of alcholic intoxication. District Surgeons Seminar, Bredasdorp. Martin, L.J. 2000. Examination of a drunken driver. District Surgeons Seminar, Bredasdorp. Martin, L.J. 2000. Inputs on gender based violence. Seminar: The Link between HIV/AIDS and gender based violence, National Department of Health, Pretoria. Martin, L.J. 2000. Forensic management of rape survivors. Seminar, Women’s Health, Department of National Health, Johannesburg. Martin, L.J. 2000. Rape homicide in Cape Town, 1996 – 1998. Research Day 2000, Division of Pathology, University of Cape Town. Martin, L.J. 2000. Sexual assault: examination of the rape survivor. Refresher Course in forensic pathology and clinical forensic medicine, Continuing Medical Education programme, Tygerberg. Martin, L.J. 2000. Forensic management of rape and collection of biological evidence. Summit: Forensic training for health professionals, National Department of Health, Pretoria.
33
Martin, L.J. 2000. Addressing the Women and Children: Barriers to Reporting Sexual Violence. XIII International AIDS Conference 2000, Durban. Martin, L.J. 2000. Impacts of violence against women. South African Men’s Forum, Seminar: Men’s role in gender issues. Martin, L.J. 2000. Collecting evidence for domestic and sexual assault. WHO and FIGO International Conference: The role of health professionals in addressing violence against women, Royal Palace, Naples, Italy.
UNPUBLISHED RESEARCH/TECHNICAL/POLICY DOCUMENTS
Els, T., Martin, L.J. & Muller, K. 2000. Clinical forensic medical standards in South Africa; an analysis and conceptual model. National committee of Forensic Pathologists. Martin, L.J. & Denny, L.A. 2000. Standardised Provincial guidelines for the management of survivors of rape or sexual assault. PAWC: Department of Health. Martin, L.J. & Denny, L.A. 2000. Report on Sexual Assault Examination. PAWC: Department of Health. Martin, L.J. & Denny, L.A. 2000. Provincial policy on the management of survivors of rape. PAWC: Department of Health.
CONSULTANCY AND OTHER ACTIVITIES BASED ON EXPERTISE DEVELOPED IN RESEARCH
Regularly consulted regarding medico-legal matters including: causes of death, inquest dockets, alcohol-related trauma and death, deaths due to poisoning, iatrogenic causes of death, expert evidence in courts and acting as assessors in court proceedings.
34
DEPARTMENT OF HAEMATOLOGY
HEAD OF DEPARTMENT: Professor N. Novitzky
DEPARTMENTAL CONTACT DETAILS
Postal Address: Department of Haematology Faculty of Health Sciences Anzio Road Observatory 7925 Telephone: SA (21) 406-6154 Fax: SA (21) 448-8607 Email: [email protected]
DEPARTMENTAL PROFILE
The Department of Haematology at Groote Schuur Hospital is a multidisciplinary unit with a broad range of activities that include outpatient clinics, a UCT Leukemia Unit, a stem cell transplantation programme, a routine service laboratory as well as tertiary diagnostic and specialised laboratories. Here, of particular importance are developments in the areas of immunophenotyping and cytogenetics. A state of the art automated karyotyping system has recently been acquired and new technologies such as fluorescence in situ hybridisation (FISH} are being explored to improve the turnaround times. Patients with elaborate diagnostic problems, haematological malignancies or requiring stem cell transplantation are referred from all provinces; predominantly the Northern and Eastern Cape and occasionally referrals from other regional institutions are also treated. Peer review systems are constantly applied, both informally during ward rounds, and through formal “Morbidity-Mortality” presentations or by reporting the outcome of patients at local or international conferences and to international registries.
Together with the Department of Radiation Oncology, patients with multiple myeloma and other lymphoproliferative disorders are treated in combined clinics. The direct application of bone marrow/haematopoietic stem cell transplantation to properly selected patients has led to a considerable improvement in the prognosis of patients with these disorders.
The apheresis section provides a service to the hospital and is central to the bone marrow/stem cell transplantation programme. Studies continue on the efficacy of plasma exchange in the emergency treatment of respiratory failure due to myasthenia gravis and the Guillain-Barré syndrome. In the hyperlipidaemias these procedures efficiently remove cholesterol and improve survival. Mobilisation of haematopoietic progenitors with growth factors is now established and attempts are being made to determine whether these manipulations lead to the release of cells, which are functionally different from their normal marrow counterparts.
Among the other multiple clinical activities, a busy Haemophilia Centre provides total care to patients with congenital bleeding disorders. This permits the appropriate and unified therapy of these genetic disorders, which start at birth, at Red Cross War Memorial Children’s Hospital, a tertiary institution also under the umbrella of UCT. Part of the routine work includes the running of an anticoagulant clinic under direct supervision of one of the consultants, by the Haematology registrars.
35
DEPARTMENTAL STATISTICS
PERMANENT AND LONG TERM STUDENTS CONTRACT STAFF Professors 1 Doctoral 1 Senior Specialists 4 Masters 3 Medical Officers 2 Undergraduate: MBCHB 3rd year 180 Specialists, part-time 2 Undergraduate: MBCHB 4th year 175 Medical Natural Scientists 1 TOTAL 359 Registrars, joint appointments 7 Acting Chief Professional Nurse 1 Control Technologists 1 Clerical and Administrative staff 6 TOTAL 25
RESEARCH FIELDS Professor N. Novitzky Haematopoietic stem cell biology; clonogenic assays; Haematopoietic stem cell transplantation; Immune Reconstitution; Haematological malignancies Dr. R. Charlewood Haematopoietic stem cell biology Dr. C. du Toit Haematopoietic stem cell transplantation; Haematological malignancies; Haemophilia Dr. J. Finlayson Molecular Biology of neoplasia: chronic myelogenous leukaemia; Coagulation abnormalities Dr. E. Holland Haematopoietic stem cell transplantation; Multiple Myeloma Dr. R. Rubinstein Molecular pathology of neoplasia; Thrombophilia
RESEARCH OUPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Davison, G.M., Novitzky, N., Kline, A., Thomas, V., Abrahams, L., Hale, G. & Waldmann, H. 2000. Immune reconstitution after allogeneic bone marrow transplantation depleted of T cells. Transplantation 15;69(7): 1341-1347. Hale, G., Jacobs, P., Wood, L., Fibbe, W.E., Barge, R., Novitzky, N., du Toit, C., Abrahams, L., Thomas, V., Bunjes, D., Duncker, C., Wiesneth, M., Selleslag, D., Hidajat, M., Starobinski, M., Bird, P. & Waldmann, H. 2000. CD52 antibodies for prevention of graft-versus-host disease and graft rejection following transplantation of allogeneic peripheral blood stem cells. Bone Marrow Transplant 26(1):69-76. Novitzky, N., Mohamed, R., Finlayson, J. & du Toit, C. 2000. Increased apoptosis of bone marrow cells and preserved proliferative capacity of selected progenitors predict for clinical response to anti-inflammatory therapy in myelodysplastic syndromes. Experimental Hematology 28(8):941- 949. Novitzky, N., Rubinstein, R., Hallett, J.M., du Toit, C.E. & Thomas, V.L. 2000. Bone marrow transplantation depleted of T cells followed by repletion with incremental doses of donor lymphocytes for relapsing patients with chronic myeloid leukemia: a therapeutic strategy. Transplantation 69(7):1358-1363. Novitzky, N. & Prindull, G. 2000. Myelodysplastic syndromes in children. A critical review of the clinical manifestations and management. American Journal of Hematology 63(4):212-222. Novitzky, N. 1999. A case of fever, confusion and anaemia in a young woman. South African Medical Journal 89(4):390. Roux, P. & Novitzky, N. 2000. The Cape Town experience with haematopoietic stem cell transplantation: the paediatric programme. South African Medical Journal 90(8):804-811.
36
Rubinstein, R., Kolia, F. & Novitzky, N. 2000. Prevalence of Factor V Leiden in three ethnic groups of patients with deep vein thrombosis in the Western Cape province of South Africa. European Journal of Haematology 65(1):78-79.
CONGRESS PRESENTATIONS
Davison, G.M., Novitzky, N., Kline, A., Thomas, V., Abrahams, L., Hale, G. & Waldmann, H. 2000. Immune Reconstitution After Allogeneic Bone Marrow Transplantation Depleted Of T Cells. CAMPATH Users Meeting. Novitzky, N., Davison, G., du Toit, C., Thomas, V. & Abrahams, L. 2000. Schedule for Mobilization of CD34+ Cells For Transplantation: Effectiveness Of A Flexible Strategy. SASMO/SASRO Congress. Novitzky, N., Makgoka, S. & Mohamed, R. 2000. Transplantation of Cytokine Mobilised Peripheral Blood Progenitor Cells is associated with improved support for the proliferation of the Stroma Adherent CD34+ Cells by the Bone Marrow Stroma. 40th Annual Congress of the Federation of South African Societies of Pathology. Novitzky, N., Makgoka, S.J. & Mohamed, R. 2000. Basic Fibroblast Growth Factor (bFGF) corrects the Proliferative Derangement of the Bone Marrow Stroma and of the CD34+ Population that follows Allogeneic Stem Cell Transplantation. The American Society of Hematology Meeting and Exposition. Novitzky, N., Mohamed, R., du Toit, C. & Finlayson, J. 2000. In Myelodysplastic Syndromes (MDS) Excessive Apoptosis (APO) in the Bone Marrow (BM) is associated to poor proliferation of CD34+ Cells that may be overcome by addition of Cytokines. SASMO/SASRO Congress. Novitzky, N., Mohamed, R., du Toit, C. & Finlayson, J. 2000. In Myelodysplastic Syndromes (MDS) Excessive Apoptosis (APO) in the Bone Marrow (BM) is associated to poor proliferation of CD34+ Cells that may be overcome by addition Of Cytokines. ESPHI Working Group's Meeting. Novitzky, N., Thomas, V. & Stubbings, H. 2000. Intensified Myeloablative Therapy and Autologous Stem Cell Transplantation for Patients with Acute Myelogenous Leukaemia: Single Centre Experience. SASMO/SASRO Congress. Novitzky, N., Thomas, V. & Stubbings, H. 2000. Intensified Myeloablative Therapy and Autologous Stem Cell Transplantation for Patients with Acute Myelogenous Leukaemia: Single Centre Experience. 40th Annual Congress of the Federation of South African Societies of Pathology. Novitzky, N., Thomas, V. & Stubbings, H. 2000. Intensified Myeloablative Therapy and Autologous Stem Cell Transplantation for Patients with Acute Myelogenous Leukaemia: Single Centre Experience. The American Society of Hematology Meeting and Exposition. Novitzky, N. 2000. Myelodysplastic Syndromes: Clonality and Immunity. 40th Annual Congress of the Federation of South African Societies of Pathology, Roux, P. & Novitzky, N. 2000. The Cape Town Experience with Haematopoietic Stem Cell Transplantation: The Paediatric Programme. CAMPATH Users Meeting.
THESES AND DISSERTATIONS PASSED FOR HIGHER DEGREES
Davison, G. 2000. Immuno Constitution post bone marrow transplantation. M.M.Sc. dissertation, University of Cape Town. Seth, Y. 2000. Review and Re-appraisal of patients treated with Splenectomy for Immune Thrombocytopaenic Purpura at five years post operatively and beyond. M. Med. dissertation, University of Cape Town.
37
DEPARTMENT OF HUMAN BIOLOGY
HEAD OF DEPARTMENT - Professor Christopher L Vaughan
DEPARTMENTAL CONTACT DETAILS Postal address: Department of Human Biology Health Sciences Faculty Observatory 7925 South Africa Telephone: SA (21) 406-6238 Fax: SA (21) 448-3291 e-mail: [email protected] web-page: http://www.uct.ac.za/depts/
DEPARTMENTAL PROFILE The year 2000 brought about major changes, not least of which was the merger of three departments to form the new Department of Human Biology. The old departments were: Anatomy and Cell Biology, Biomedical Engineering, and Physiology. We anticipate that the new department will benefit from the merger in terms of scientific collaboration, increased efficiency and improved utilisation of resources. The areas of research activity include: cell and developmental biology; anthropology; medical education; mineral metabolism; electrophysiology; neuroscience; post mortem changes; sports science; and biomedical engineering. The department of Human Biology houses two separate MRC/UCT Research Units.
The MRC/UCT Research Unit for Exercise Science and Sports Medicine was formalised in 1989 and is under the directorship of Professor Tim Noakes. The focus is on postgraduate education, in particular sports medicine, sports physiotherapy and the exercise sciences. The Unit forms the core of the medical, scientific and outreach programmes of the Sports Science Institute of South Africa in Newlands in which building the teaching and research laboratories of the Unit are housed. Its large postgraduate enterprise leads to degrees in exercise science, biokinetics and sports medicine.
The MRC/UCT Medical Imaging Research Unit was launched in May 2000 and is under the directorship of Professor Kit Vaughan. The focus is on the application of imaging technologies to address medical problems that are specific to South Africa, including trauma, cancer, tuberculosis, and foetal alcohol syndrome. Drawing together academics and postgraduate students from the Faculties of Science, Engineering and Health Sciences, the Unit is working on low dose digital X-rays, telemedicine, high-resolution electroencephalography, and surgical navigation technologies. The Unit will form the core of the Allan Cormack Institute for Medical Imaging, to be housed in the Anatomy Building, which will honour the UCT alumnus who earned a Nobel Prize in Medicine for his pioneering research in developing the computer tomographic (CT) scanner.
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG TERM CONTRACT STAFF
UNIVERSITY STAFF JMS STAFF PAWC STAFF Professors 2 Professors 1 Senior Lecturer 2
Associate Professor 8 TOTAL 1 Lecturers 1
Senior Lecturers 8 TOTAL 3
Research Staff 7
Technical and Support Staf 18 Admin and Clerical Staff 5 TOTAL 48
38
STUDENTS HONORARY STAFF
Doctoral 57 Honorary Associate 1 Masters 42 Professors Mphil 2 Honorary Lecturers 8 Honours 14 TOTAL 9 Undergraduate 1107 TOTAL 1222
RESEARCH FIELDS
PERMANENT STAFF
Professor Christopher L Vaughan Hyman Goldberg Professor and Department Head, Director of UCT/MRC Medical Imaging Research Unit, musculoskeletal biomechanics, theories of human gait, medical imaging Professor Tim Noakes Discovery Health Chair of Exercise and Sports Science and Director of UCT/MRC Research Unit for Exercise Science and Sports Medicine (RUESSM) - A neural governor that prevents the development of myocardial ischaemia during maximal exercise; the hyponatraemia of exercise; mechanisms whereby carbohydrate depletion causes exercise fatigue Professor W.J. Els Molecular membrane biology; regulation of membrane ion channels Associate Professor Steve Dennis Biochemistry of exercise Associate Professor Wayne Derman RUESSM - Skeletal muscle dysfunction in chronic disease; exercise training in chronic disease Associate Professor S.H. Kidson Developmental biology; melanocytes; eye development and glaucoma Associate Professor Mike Lambert RUESSM – Muscle damage; regeneration, overload, heart rate, anabolic steroids, human performance, ergogenic aids Associate Professor Vicki Lambert RUESSM - Fat metabolism during exercise; effect of ante-natal nutrition on subsequent health; predictors of health Associate Professor G.J. Louw Human growth; medical curricula; skeletal analysis Associate Professor A.G. Morris Physical anthropology Associate Professor Vivienne Russell Attention deficit hyperactivity disorder Associate Professor Martin Schwellnus RUESSM - Epidemiology of sports injuries; biomechanical factors associated with sporting injuries Dr David A Boonzaier Senior Lecturer; rehabilitation technology Dr Andrew Bosch RUESSM – Muscle glycogen; fatigue; training; performance Dr Wayne L Capper Lecturer; physiological flow Dr Malcolm Collins RUESSM - Genetic contributions to sporting excellence; molecular mechanisms in training adaptations and in exercise-induced fatigue Dr M.-A. Davies (joined the department in 2000) - Lecturer; bioarchaeology Dr L.-M. Holtzhausen (left the department in 2000) - Senior Lecturer; sports medicine; bioarchaeology Dr Laurie Kellaway In vivo and in vitro visual cortical mechanisms
39
Dr D.M. Lang (joined the department in 2000) - Lecturer; nervous system development; axon growth and regeneration Dr David Querido Physico-chemical estimation of postmortem interval Dr C.P. Slater Senior Lecturer; interactive multimedia for anatomy teaching Dr Alan St Clair Gibson RUESSM - Neural mechanisms in fatigue; neural mechanisms in locomotion Dr C.M.R. Warton Senior Lecturer; medical education and teaching materials Ms D. Constant Senior Lecturer; bioarchaeology; skeletal analysis Mr Mladen A Poluta Senior Lecturer; Director, Healthcare Technology Management Mrs L. van der Merwe (joined the department in 2000) - Lecturer; cell biology; imaging techniques
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Andrew, C. 2000. Sensorimotor EEG rhythms and their connection to local/global neocortical dynamic theory. Behavioural and Brain Sciences 23(3):399-400. Brossy, J.-J., Plos, A.L., Blackbeard, J.M. & Kline, A. 2000. Diseases acquired by captive penguins: what happens when they are released into the wild? Marine Ornithology 27:185-186. Burke, L.M., Hawley, J.A., Schabort, E.J., St Clair Gibson, A., Mujika, I. & Noakes, T.D. 2000. Carbohydrate loading failed to improve 100-km cycling performance in a placebo-controlled trial. Journal of Applied Physiology 88: 1284-1290. Clark, V.R., Hopkins, W.G., Hawley, J.A. & Burke, L.M. 2000. Placebo effect of carbohydrate feedings during a 40-km cycling time trial. Medice and Science in Sports and Exercise 32: 1642-1647. Goedecke, J.H., St Clair Gibson, A., Grobler, L., Collins, M., Noakes, T.D. & Lambert, E.V. 2000. Determinant of the variability in substrate utilisation at rest and during exercise in trained athletes. American Journal of Physiology 279: e1325-e1334. Grobler, L.A., Schwellnus, M.P., Trichard, C., Calder, S., Noakes, T.D. & Derman, W.E. 2000. Comparative effects of zopiclone and loprazolam on psychomotor and physical performance in active individuals. Clinical Journal of Sports Medicine 10: 123-128. Lambert, M.I. & Keytel, L.R. 2000. Training habits of top runners in different age groups in a 56 km race. South African Journal of Sports Medicine 7: 27-32. Ledger, M., Holtzhausen, L.-M., Constant, D. & Morris, A.G. 2000. Biomechanical beam analysis of long bones from a late 18th century slave cemetery in Cape Town, South Africa. American Journal of Physical Anthropology 112:207-216. London, L., Thompson, M.L. & Capper, W. 2000. Utility of vibration sense testing for use in developing countries: comparison of extinction time on the tuning fork to vibration thresholds on the Vibratron II. NeuroToxicology 21(5):743-753. Lowery, M., Vaughan, C.L., Nolan, P. & O'Malley, M.J. 2000. Spectral compression of the electromyographic signal due to decreasing muscle fiber conduction velocity. IEEE (The Institute of Electrical and Electronics Engineers) Transactions on Rehabilitation Engineering 8(3): 353-361. Mayers, L.B. & Noakes, T.D. 2000. A guide to Treating Ironman Triathletes at the Finish Line. The Physician and Sportsmedicine 28: 35-50. Mbambo, Z.H. & Lambert, M.I. 2000. Variations in the heart rate of an elite long distance runner during races of varying distances. South African Journal of Sports Medicine 7: 17-20. Noakes, T.D. & Durandt, J.J. 2000. Physiological requirements of cricket. Journal of Sports Science 18: 1-11. Noakes, T.D. 2000. Hyponatremia in distance athletes. Physician and Sportsmedicine 28: 71-76. Noakes, T.D. 2000. Taboo: Why black athletes dominate sport and why we're afraid to talk about it. South African Medical Journal 90: 1193-1194.
40
Rawdon, B.B. 2000. Can gastric endoderm change the regionally specific inducing ability of presumptive small intestinal mesoderm? Developmental Dynamics 219:402-416. Rawdon, B.B. & Larsson, L.-I. 2000. Development of hormonal peptides and processing enzymes in the embryonic avian pancreas with special reference to co-localization. Histochemistry and Cell Biology 114:105-112. Russell, V.A. 2000. The nucleus accumbens motor-limbic interface of the spontaneously hypertensive rate (SHR) as studied in-vitro by the superfusion technique. Neuroscience & Biobehavioural Reviews 24: 133-136. Russell, V.A., Allie, S. & Wiggins, T. 2000. Increased noradrenergic activity in prefrontal cortex slices of an animal model for attention-deficit hyperactivity disorder - the spontaneously hypertensive rat. Behavioural Brain Research 117: 69-74. Russell, V.A., De Villiers, A., Sagvolden, T., Lamm, M. & Taljaard, J. 2000. Brain Research Bulletin 53: 187-192. Schabort, E.J., Killian, S.C., St Clair Gibson, A., Hawley, J.A. & Noakes, T.D. 2000. Medicine & Science in Sports and Exercise 32: 844-849. Schabort, E.J., Wilson, G. & Noakes, T.D. 2000. Dose related elevations in venous pH with citrate ingestion do not alter 40-km cycling time-trial performance. European Journal of Applied Physiology 83: 320-327. Sharwood, K.A., Lambert, M.I., St Clair Gibson, A. & Noakes, T.D. 2000. Changes in muscle power and neuromuscular efficiency after an eccentric challenge in veteran long distance runners. Clinical Journal of Sports Medicine 10: 129-135. Smith, R.S., Zabaleta, A., Kume, T., Savinova, O.V., Kidson, S.H., Martin, J.E., Nishimura, D.Y, Alward, W.L., Hogan, B.L. & John, S.W. 2000. Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development. Human Molecular Genetics 9:1021-1032. Sole, G., Lambert, M.I. & Juritz, J. 2000. The role of the physiotherapy in Sports Medicine: perceptions of orthopaedic surgeons, sports physicians, biokineticists and physiotherapists. South African Journal of Physiotherapy 56: 29-35. Sparling, P.B., Owen, N., Lambert, E.V. & Haskell, W.L. 2000. In Promoting Physical Activity: The New Imperative for Public Health. Health Education Research 15: 367-376. Speedy, D.B., Noakes, T.D., Rogers, I.R., Hellemans, I., Kimber, N.E., Boswell, D.R., Campbell, R. & Kutter, J.A. 2000. A prospective study of exercise-associated hyponatremia in two ultradistance triathletes. Clinical Journal of Sports Medicine 10: 136-141. St Clair Gibson, A., Lambert, M.I., Myburgh, K.H. & Noakes, T.D. 2000. Quadriceps and hamstring muscle function in complete and parial anterior cruciate ligament deficiency. South African Journal of Sports Medicine 7: 21-26. St Clair Gibson, A., Lambert, M.I., Myburgh, K.H., Walters, J., Vaughan, C.L., O'Malley, M.J. & Noakes, T.D. 2000. The relationship between functional capacity, muscle size and strength in chronic ACL deficient and ACL reconstructed individuals. South African Journal of Physiotherapy 56: 12-18. St Clair Gibson, A., Perold, J., Watermeyer, G.A., Latouf, S.E., Hawley, J.A., Lambert, M.I. & Noakes, T.D. 2000. Veteran athletes exercise at higher maximum heart rates than are achieved during standard exercise (stress) testing. South African Medical Journal 90: 141-146. Vaughan, C.L. 2000. The professor as entrepreneur. South African Journal of Science 96(April):154.
CHAPTERS IN BOOKS
Hawley, J.A., Schabort, E.J. & Noakes, T.D. 2000. Distance running. In Maughan, R.J. (ed.) Nutrition in Sport: 550-561. Oxford, London: Blackwell Science Ltd. Morris, A.G. 2000. A Canadian Mounted Rifleman at War, 1899-1902. Second Series No.31. Cape Town: Van Riebeeck Society. Noakes, T.D. 2000. Exercise in the heat. In Brukner, P.K. (ed.) Clinical Sports Medicine (2nd edition): 798-806. Australia: McGraw-Hill Companies Inc. Noakes. T.D. 2000. Medical coverage of endurance events. In Brukner, P.K. (ed.) Clinical Sports Medicine (2nd edition): 806-865. Australia: McGraw-Hill Companies Inc. Noakes, T.D. 2000. Hyperthermia, hypothermia and problems of hydration. In Shephard, R.J. & Astrand, P.O. (eds) Endurance in Sport (2nd Edition): 591-613. London: Blackwell Science Ltd. Noakes, T.D. 2000. Medical considerations for runners. In Hawley, J.A. (ed.) Handbook of Sports Medicine and Science. Running: 72-89. London: Blackwell Science Ltd.
41
PUBLISHED CONFERENCE PROCEEDINGS
Capper, W.L. & Myers, L. 2000. Gestational age dependency of umbilical flow waveforms: An investigation using a lumped parameter model. Digest of papers of the 2000 World Congress on Medical Physics and Biomedical Engineering and the Proceedings of the 22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Chicago’s Navy Pier. [Refereed research article on CD Rom] Hough, J., Jones, D.T.L. & Vaughan, C.L. 2000. Assessment of a stereophotogrammetric patient positioning system for proton therapy. Proceedings of the Sixth International Symposium on the 3D Analysis of Human Movement, Cape Town, South Africa, 58-61. Meintjes, E.M., Adams, L.P., Stekhoven, A., Vaughan, C.L., Taylor, A.G., Fieggen, A.G. & Peter, J. 2000. An application of Pepper's Ghost to the 3D localisation of lesions in neurosurgery. Proceedings of the Sixth International Symposium on the 3D Analysis of Human Movement, Cape Town, South Africa, 54-57. Myers, L.J. & Capper, W.C. 2000. The effect of arterial curvature on Doppler velocity blood flow waveform indices. Digest of papers of the 2000 World Congress on Medical Physics and Biomedical Engineering and the Proceedings of the 22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Chicago’s Navy Pier. [Refereed research article on CD Rom] Tabakin, D. & Vaughan, C.L. 2000. A comparison of 3D gait models based on the Helen Hayes marker set, Proceedings of the Sixth International Symposium on the 3D Analysis of Human Movement, Cape Town, South Africa, 98-101.
PUBLISHED ABSTRACTS
Bukenya, E.M., Louw, G.J. & Morris, A.G. 2000. The role of facet (zygapophyseal) size in primates of different locomotive behaviour. Anatomical Society of Southern Africa. Buthelezi, B.P. & Louw, G.J. 2000. Is age at menarche determined by father's education? Anatomical Society of Southern Africa. Els, W.J., Butterworth, M.B., Rhodes, S. & Blazer-Yost, B. 2000. Evidence for forskolin-induced GFP ENaC trafficking in A6 epithelial cells. Experimental Biology Meeting, San Diego, USA. FASEB (Federation of American Societies for Experimental Biology) Journal 14:C-165. Goedecke, J.H., St Clair Gibson, A., Grobler, L., Collins, M., Noakes, T.D. & Lambert, E.V. 2000. Differences in substrate utilization at rest and during submaximal exercise in high- and low-fat oxidizers. Medical Science Sports & Exercise 32(5): S346. Kubukeli, Z.N., St Clair Gibson, A., Collins, M., Noakes, T.D. & Dennis, S.C. 2000. The effects of high intensity interval training, taper and 6 weeks of habitual training on 100-km time trial performance in endurance trained cyclists. Medical Science Sports & Exercise 32 (5): S132. Lambert, M.I., Dugas, J.P., Kirkman, M.C., Waldeck, M.R., Bekker, J.P.I., Mokone, G.G., Drake, B.S. & Barlowe, G. 2000. Changes in running speeds during a 100 km ultramarathon race. Medical Science Sports & Exercise 32(5): S191. Manyaapelo, T. & Louw, G.J. 2000. An investigation into the degree of sexual dimorphism in Black and in White Medical students. Anatomical Society of Southern Africa. Marino, F.E., Mbambo, Z., Kortekass, E., Wilson, G., Lambert, M.I., Noakes, T.D. & Dennis, S.C. 2000. Advantages of smaller body mass during distance running in warm humid environments Medical Science Sports & Exercise 32(5): S157. Naidoo, S. & Louw, G.J. 2000. A comparative analysis of trauma cases treated at Tygerberg Hospital, Cape Town, during the period 1997 to 1999. Anatomical Society of Southern Africa. Pratt, M., Booth, M. Craig, C.L., Ainsworth, B., Sjostrom, M., Matsudo, V., Lambert, E.V. & Bauman, A. 2000. Global standards in measurement, reporting, and surveillance of physical activity: dreams of reality. Medical Science Sports & Exercise 32(5, Suppl ): S37. Smith, J., Grobler, A., van der Merwe, E.L., Geerts, L. & Schneider, J.W. 2000. The effect of absent or retrograde end-diastolic flow (AREDF) in the umbilical artery on human lung development. American Thoracic Society, Toronto, Canada. Smith, J., Grobler.,A., Schneider, J., van der Merwe, E.L. & Geerts, L. 2000. The effect of absent or retrograde end-diastolic flow in the umbilical artery on human lung development. 7th World International Association for Maternal and Neonatal Health Conference, Stellenbosch, South Africa.
42
Vaughan, C.L. 2000. Allan MacLeod Cormack: a Capetonian whose work led to the development of the CT scanner and the award of the Nobel Prize for Medicine. 10th Biennial Congress of the South African Lymphoma Study Group, Cape Town, South Africa.
THESES AND DISSERTATIONS PASSED FOR HIGHER DEGREES
Bukenya, E.E.M. 2000. The vertebral column in humans and selected non-human primates, and the functional structure of its transitional elements. Ph.D. thesis, University of Cape Town. Clarke, R.E. 2000. Cell-type specific regulation of the chicken tyrosinase promoter. M.Sc.(Med) dissertation, University of Cape Town. Daries, H.N. 2000. Fluid replacement in long distance runners: 1-51. M.Sc. (Med) dissertation, University of Cape Town. Goedecke, J.H. 2000. Fat as a fuel for Exercise: 1-273. Ph.D. thesis, University of Cape Town. Hough, J.K. 2000. Patient positioning in proton therapy: 1-146. M.Phil. dissertation, University of Cape Town. John, L. 2000. An inverse electrical transmissionline to estimate the severity and location of lower limb arterial stenosis: 1-181. Ph.D. thesis, University of Cape Town. Lehmann, M. 2000. Design and manufacture of a coronary stent for the South African market: 1-106. M.Sc.(Med) Biomedical Engineering dissertation, University of Cape Town. Rauch, H.G.L. 2000. Fuel subsrate kinetics during ultra-endurance exercise: The interaction between carbohydrate, fat and lactate oxidation. Ph.D. thesis, University of Cape Town. Stern, V. 2000. The effectiveness of ergonomic training on visual display terminal operators: 1-183. M.Sc.(Med) dissertation, University of Cape Town. Tabakin, D. 2000. A comparison of 3D biomechanical models in walking: 1-112. M.Sc.(Med) Biomedical Engineering dissertation, University of Cape Town. Truter, E.J. 2000. Immunospecific albumin microspheres as a drug delivery system for cisplatin and 5- fluorouracil for the treatment of ovarian adenocarcinoma. Ph.D. thesis, University of Cape Town.
UNIVERSITY PUBLICATIONS AND PUBLICATIONS OF A POPULAR NATURE
Morris, A.G. 2000. Comment on "Genes, Tribes and African History" by S.MacEachern. Current Anthropology 41:376-377. Morris, A.G. 2000. Response from Researcher to "Skeletons in the cupboard: museums and the incipient trade in human skeletons, 1907-1917" by M.Legassick & C. Rassool: 73-76. South African Museum and McGregor Museum. Slater, C. 2000. The functional anatomy of the knee joint. An illustrated overview of the interrelationship of the structures of the knee. Continuing Medical Education 18:778-786. Smith, J., Grobler.,A., van der Merwe, E.L., Geerts, L. & Schneider, J.W. 2000. The effect of absent or retrograde end-diastolic flow (AREDF) in the umbilical artery on human lung development. Academic year day – Medical School Stellenbosch. Vaughan, C.L. 2000. Medical Imaging: more than X-rays. MRC News 31(2): 4-6.
43
DEPARTMENT OF HUMAN GENETICS
HEAD OF DEPARTMENT – Prof RS Ramesar (Acting Head)
DEPARTMENTAL CONTACT DETAILS Postal address: Department of Human Genetics University of Cape Town Medical School Observatory 7925 South Africa Telephone: SA (21) 406-6297 Fax: SA (21) 447-7703 e-mail: [email protected] Webpage: http://www.uct.ac.za/depts/genetics/
DEPARTMENTAL PROFILE
The Department of Human Genetics is committed to providing a world-class clinical service which is underpinned by a strong research programme and laboratory services. A significant proportion of basic research projects are aimed at elucidating the underlying genetic basis of disease, which upon fruition, lead to the provision of services for the diseases under investigation. The interaction between researchers and clinicians is strengthened by the fact that the senior laboratory staff are accredited by the HPCSA as genetic counsellors, and that they are directly involved in the departmental clinical services. Research in the Department has attracted considerable international and local funding. The largest research endeavour currently involves the genetics of retinal degenerative disorders (RDDs). A research highlight in 2000 was the establishment of a Colorectal Cancer Research Consortium involving pathologists, surgeons and geneticists (from UCT and the University of Stellenbosch Medical School) under the directorship of Professor Ramesar). Results emerging from this dynamic research group have already lead to the establishment of predictive testing protocols for some forms of colorectal cancers. Other major departmental research initiatives include the investigation of the genetic basis of retinal degenerative disorders, neurodegenerative disorders, psychiatric disorders (bipolar disorder and depression), muscular dystrophies and connective tissue disorders. A positive new development for the Department has been the awarding of an MRC/UCT Research Unit for Human Genetics which is to be activated in 2001.
DEPARTMENTAL STATISTICS 2000
UCT STAFF UCT/GSH PERSONNEL
Professors 1 Registrars 1 Associate Professors 1 TOTAL 1 Research Staff (4 x P/T) 15 Technical Support Staff 5 HONORARY STAFF Admin. & Sec. Staff (1 x P/T) 2 Departmental Assistants 2 Honorary Senior Lecturers 2 TOTAL 26 TOTAL 2
STUDENTS
GSH PERSONNEL Doctoral 4 Masters 1 Medical Officers (P/T – Sessions) 3 Hons 2 Medical Technical Officers (2 x P/T) 3 TOTAL 7 Registered Nurses 2 TOTAL 8 44
RESEARCH FIELDS
Professor Raj Ramesar Head of Department (Acting); cancer of the colon; genetics of psychiatric disorders; retinal degenerative disorders Dr Donald Basel Registrar; spina bifida; dysmorphology Associate Professor Jacquie Greenberg Retinal degenerative disorders; genetics of neurological disorders; neuromuscular disorders Dr George Rebello Post-doctoral fellow; bioinformatics; retinal degenerative disorders Ronald Smart Deletion 22q syndrome
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Astuto, L.M., Weston, M.D., Carney, C.A., Hoover, D.M., Cremers, C.W.R.J., Wagenaar, M., Moller, C., Smith, R.J.H., Pieke-Dahl, S., Greenberg, J., Ramesar, R., Jacobson, S., Ayuso, C., Heckenlively, J.R., Tamayo, M., Gorin, M.B., Reardon, W. & Kimberling, W.J. 2000. Genetic heterogeneity of Usher Syndrome: Type I: mutation and linkage analysis of 155 families with Usher Type I. American Journal of Human Genetics 67:1569-1574. Basel, D. & Goldblatt, J. 2000. Tibial aplasia—VACTERL association, a new syndrome? Clinical Dysmorphology 9(3):205-208. Basel, D., Sobey, G., Gardner, J. & Beighton, P. 2000. The Gordon Syndrome Revisited. The South African Medical Journal 90(9): 864-867. Goldberg, P.A., Madden, M.V., Harocopos, C., Grobbelaar, J.J., Kotze, M.J., Marx, M.P., de Jong, G. & Ramesar, R. 2000. Inherited Colon Cancers. Editorial, South African Medical Journal 90(7): 703-705. Ianakiev, P., Kilpatrick, M.W., Daly, M.J., Zolindaki, A., Bagley, D., Beighton, G., Beighton, P. & Tsipouras, P. 2000. Localization of an acromesomelic dysplasia on chromosome 9 by homozygosity mapping. Clinical Genetics 57:278-283. Inakiev, P., Kilpatrick, M.W., Toudjarska, I., Basel, D., Beighton, P. & Tsipouras, P. 2000. Split- hand/split-foot malformation is caused by mutations in the p63 gene on 3q27. American Journal of Human Genetics 67:59-66. May, P.H., Brooke, L., Gossage, J.P., Croxford, J., Adnams, C., Jones, K.L., Robinson, L. & Viljoen, D. 2000. Epidemiology of Fetal Alcohol Syndrome in a South African Community in the Western Province. American Journal of Public Health 90(12): 1905-1912. Ramesar, R.S., Madden, M.V., Felix, R., Harocopos, C.J., Westbrook, C.A., Jones, G., Cruse, J.P. & Goldberg, P.A. 2000. Molecular genetics improves the management of hereditary non-polyposis colorectal cancer. South African Medical Journal 90(7): 709-714. Roberts, L., Ramesar, R. & Greenberg, J. 2000. Low frequency of rhodopsin mutations in South African patients with autosomal dominant retinitis pigmentosa. Clincal Genetics 58:77-78. Weston, M.D., Eudy, J.D., Fujita, S., Yao, S., Usami, S., Cremers, C., Greenberg, J., Ramesar, R., Martini, A., Moller, C., Smith, R.J., Sumegi, J. & Kimberling, W.J. 2000. Genomic structure and identification of novel mutations in Usherin, the gene responsible for Usher Syndrome Type IIa. American Journal of Human Genetics 66(4):1199-1210.
CHAPTERS IN BOOKS
Beighton, P. 2000. Ehlers-Danlos Syndrome in Rheumatological Procatice. In Rovensky, J. (ed.) Rheumatological Theory and Procatice VI: 599-606. Slovak Republic: Vyddavatelstvo Osveta, Slovak Republic.
CONFERENCE ABSTRACTS
Felix, R., Algar, U., Goldberg, P. & Ramesar, R.S. 2000. Molecular genetic analysis of hereditary colorectal cancer in South Africa. Human Genetics Society of Australasia, Wellington, New Zealand. (Poster presentation)
45
Greenberg, J., Bardien-Kruger, S., Rebello, G., Ramesar, R.S. 2000. Gene mapping: the role of links and luck and most of all, accurate clinical information in linkage analysis. Ophthalmology Society of Southern Africa (OSSA) Swaziland. (Oral presentation) Greenberg, J., Roberts, L. & Ramesar, R.S. 2000. Unusual frequencies of rhodopsin mutations and polymorphisms in southern African patients with Retinitis Pigmentosa. IX International Symposium on Retinal Degeneration: Durango, Colorado. (Poster presentation) Ramesar, R., Rebello, G. & Greenberg, J. 2000: Inherited retinal degenerative disorders: Sowing the seeds for genetic research in Southern Africa. Vision Quest 2000, 11th World Conference of Retina International, Toronto, Canada. (Oral presentation) Ramesar, R.S., Felix, R., Algar, U. & Goldberg, P. 2000. Molecular Epidemiology of Hereditary Nonpolypotic Colorectal Cancer in South Africa. 12th International Conference of the International Collaborative Group for HNPCC, Tiberias, Galilee, Israel. (Oral presentation) Ramesar, R.S., Felix, R., Algar, U. & Goldberg, P. 2000. Hereditary Nonpolypotic Colorectal Cancer: Molecular Genetics to Management - The Challenges. 12th International Collaborative Group- HNPCC Meeting, Tiberias, Galilee, Israel. (Oral presentation) Ramesar R.S., Felix, R., Algar, U. & Goldberg, P. 2000. Molecular epidemiology of hereditary colorectal cancer in South Africa, European Society of Human Genetics Meeting, Amsterdam. (Oral presentation) Ramesar, R.S., Pietersen, E., Koen, M., Cupido, D. & Kibel, D. 2000. Suicide in families with Bipolar Disorder. Fourth Southern African Conference on Suicidology, Durban. (Oral presentation)
THESES AND DISSERTATIONS PASSED FOR HIGHER DEGREES
Goliath, R. 2000. Towards identifying the ADRP gene in a large South African retinitis pigmentosa family: 1-190. Ph.D. thesis, University of Cape Town. Stephen, L.X.E. 2000. Osteogenesis imperfecta: oral manifestations of dentinogenesis imperfecta and its value as a diagnostic discriminant:1-350. Ph.D. thesis, University of Cape Town.
46
DEPARTMENT OF IMMUNOLOGY (incorporating MRC/UCT infectious Immunology unit, Allergology and Tissue Immunology units)
HEAD OF DEPARTMENT: Professor Bernhard Ryffel
DEPARTMENT CONTACT DETAILS
Postal Address: Department of Immunology H53, H Floor, Room 22 Old Main Building Groote Schuur Hospital Observatory 7925 Cape Town South Africa Telephone: SA (21) 406-6616/6147 Fax: SA (21) 448-6116 e-mail: [email protected]
DEPARTMENTAL PROFILE
This department comprises four divisions : • Immunology, Head: Professor Bernhard Ryffel • Infectious Immunology, Head: Assoc. Professor Frank Brombacher These two divisions form an MRC Unit. • Allergology, Head: Assoc. Professor Paul Potter • Transplantation Immunology, Head: Assoc. Professor Ernette du Toit All divisions are involved in providing clinical services and developing new laboratory diagnostic tools based on clinical and experimental research. Allergology also provides a very active clinic. All sections are extensively involved in local, national and international collaboration. The department provides transgenic animals and a specific pathogen free (SPF) facility for research collaboration at a national level.
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG STUDENTS TERM CONTRACT STAFF Professors 1 Postdoctoral 6 Associate Professors 3 Doctoral 8 Lecturers 1 Masters 3 Research Staff 26 Honours 3 Technical Support Staff 4 TOTAL 20 Administrative Staff 3 TOTAL 38
RESEARCH FIELDS
B Ryffel TB; HIV; Vaccine A Lopata Identification specific allergens; Anasikis pegreffi G Hanekom Cutaneous melanoma P Burger Fibroblast growth factor; prostatic stem cells ID 47
E L Wilson Balance VEGF /angiopoietin expression F Brombacher IL-4, IL-13 in innate and adaptive immunity E du Toit Transplantation, population genetics, HLA
RESEARCH ASSOCIATES
Dr Christoph Hoelscher Generation and analysis of cell-specific IL-4 receptor – alpha gene-deficient mice
DISTINGUISHED VISITORS
Dr Horst Mossmann Max Planck Institute, Freiburg, Germany Dr Chantal de Chastellier Pathogen Interaction Laboratory Necker, Paris
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED JOURNAL ARTICLES
Berman, D., Nurse, B., Haus, M., Puterman, A.S., Potter, P.C. & Weinberg, E.G. 2000. Allergen - specific IgE profile in Xhosa asthmatic children. ACI International S2: 188. Berman, D., Nurse, B., Haus, M., Puterman, A.S., Weinberg, E.G. & Potter, P.C. 2000. PBMC’s from both Atopic Asthmatic and Non-Atopic children show a TH2 Cytokine response to house dust mite Allergen. Journal of Allergy and Clinical Immunology 106: 84-91. Berman, D., Puterman, A.S., Haus, M., Nurse, B., Weinberg, E.G. & Potter, P.C. 2000. Correlation of allergen – specific lymphocyte proliferation and cytokine release in atopic asthmatic and healthy Xhosa children. ACI International S2: 49. Bowie, R.C.K., Sweijd, N.A., Evans, B.S. & Lopata, A.L. 2000. Molecular genetics and marine organisms. Hydrobiologia 420: 153-164. Brombacher, F. 2000. The role of interleukin-13 in infectious diseases and allergy. BioEssays 22:646- 656 (I.F. = 7.3). Brombacher, F., Mohrs, M., Wen, J.D., Köhler, G., Ryffel, B., Schaub, G.A., Mossman, H. & Hölscher, C. 2000. Tumor Necrosis Factor Alpha-Mediated Toxic Shock in Trypanosoma cruzi –Infected Interleuken 10-Deficient Mice. Infection and Immunity July: 4075-4083. Ellis, J.T., Harper, P.A.W., Reichel, M.P. & Atkinson, R. 2000. Progress in the Serodiagnosis of Neospora caninum Infections of Cattle. Parasitology Today 16 (3). Hölscher, C., Mohrs, M., Dai, W.J., Köhler, G., Ryffel, B., Schaub, G.A., Mossmann, H. & Brombacher, F. 2000. TNF-a-mediated toxic shocksyndrome in Trypanosoma cruzi-infected IL- 10 deficient mice. Inf. & Immun. 68:1773-1780 .(I.F.= 3.7). Houston, K. M., Wilson, E.H., Eyres, L., Brombacher, F., Harnett, M.M., Alexander, J. & Harnett, W. 2000. Presence of phosphorylcholine on a filarial nematode protein influences immunoglobulin G subclass response to the molecule and by an interleukin-10-dependent mechanism. Inf. & Immun. 68:5466-5468 (I.F.= 3.7). Jacobs, M., Brown, N., Allie, N., Guler, R. & Ryffel, B. 2000. Increased resistance to mycobacterial infection in the absence of binterleuken-10. Immunology 100: 494-501. Jacobs, M., Brown, N., Allie, N. & Ryffel, B. 2000. Fatal Mycobacterium bovis BCG Infection in TNF-LT-α-Deficient Mice. Clinical Immunology 94(3): 192-199. Jacobs, M., Guler, R., Vesin, D., Olleros, M.L.,Vassalli, P., Chvatchko, Y., Garcia, I. & Ryffel, B. 2000. Lethal Mycobacterium Bovis Bacillus Calmette Guérin Infection in Nitric Oxide Synthase 2-Deficient Mice:Cell-Mediated Immunity Requires Nitric Oxide Synthase 2. Laboratory Investigation 80(9): 1385. Jacobs, M., Marino, M., Brown, N., Abel, B., Bekker, L., Quesniaux, V.J.F., Fick, L. & Ryffel, B. 2000. Correction of Defective Host Response to Mycobacterium Bovis BCG Infection in TNF- Deficient Mice by Bone Marrow Transplantation. Laboratory Investigation 80(6): 9011. Jeebhay, M.F., Lopata, A.L. & Robins, T.G. 2000. Seafood processing in South Africa: A study of working practices, occupational health services and allergic health problems in the industry. Occupational. Medicine 50(6): 406-413.
48
Mohrs, M., Hölscher, C. & Brombacher, F. 2000. IL-4Ra deficientBalb/c mice have an unimpaired Th2 polarization in response to Leishmania major infection. Inf. &Immun. 68:1773-1780. (I.F.= 3.7).
49
Okano, M., Satoskar, A.R., Abe, M., Harn, D.A., Okana, M., Nishizaki, K., Takeda, Y., Yoshino, T., Brombacher, F. & Salm, S.N., Koikawa, Y., Ogilvie, V., Tsujimura, A., Coetzee, S., Moscatelli, D., Moore, E., Lepor, H., Shapiro, E., Sun, T-T. & Wilson, E.L. 2000. Generation of active TGF- ß by prostatic cell co-cultures using novel basal and luminal prostatic cell lines. J. Cell Physiol. 184: 70-79. Salm, S.N., Koikawa, Y., Ogilvie, V., Tsujimura, A., Coetzee, S., Moscatelli, D., Moore, E., Lepor, H., Shapiro, E., Sun, T-T. & Wilson, E.L. 2000. Transforming growth factor ß is an autocrine mitogen for a novel androgen-responsive murine prostatic smooth muscle cell line, PSMC1. J. Cell Physiol. 185: 416-434. Satoskar, A.A. 2000. Interleukin-4-independent production of Th2 cytokines by nasal lymphocytes and nasal eosinophilia in murine allergic rhinitis. Allergy 55:723-731. (I.F.= 0.9).
50
DEPARTMENT OF LOGOPAEDICS
HEAD OF DEPARTMENT – Professor Seppo Kalervo Tuomi
DEPARTMENTAL CONTACT DETAILS Postal Address: Department of Logopaedics University of CapeTown E 47 Old Main Building Groote Schuur Hospital Observatory 7925 South Africa Telephone: SA (21) 406-6313 Fax: SA (21) 406-6645 Email: [email protected]
DEPARTMENTAL PROFILE
Our principal functions are teaching, research and clinical training in communication disorders. Several specialised clinics are in existence. A voice clinic, which includes use of stroboscopy, is run in collaboration with the Otolaryngology Department, and offers opportunities for training and research using highly specialised equipment. A video-fluoroscopy clinic, for assessment of swallowing disorders, is run in co-operation with the Department of Radiology. A voice restoration clinic for post- laryngectomy patients is a department strength. A centre for aural rehabilitation for deaf children, initiated and established by the Department, is now recognised by the Education Department and provides rehabilitation for deaf children at primary, secondary and tertiary health care levels. A Hearing and Research Centre (HARK) mobile clinic has been instituted in association with the British Commonwealth Society and provides primary audiological services to peri-urban and rural communities in Western Cape districts. Our focus is community-based teaching. Off-site clinics rendering child, adult and geriatric services are successfully run by supervised fourth year students. Applied research in line with national research priorities is being undertaken. Research activities include the study of inter- cultural communication, the development of culturally appropriate assessment and therapeutic tools, deaf studies and epidemiological studies. Community involvement has extended to advocacy and post- creation within the educational, health and private sectors. The Department is an important centre for postgraduate education in Speech-Language Pathology and Audiology.
DEPARTMENTAL STATISTICS 2000
PERMANENT STAFF AND LONG STUDENTS TERM CONTRACT STAFF
Associate Professor and Head of 1 Doctoral 2 Department Masters 18 Senior Lecturer 1 Undergraduate 105 Lecturers 6 TOTAL 125 Asst. Lecturer 1
TOTAL 9 CLINICAL STAFF Clinical staff (full time) 5 Clinical staff (part time) 1 TOTAL 6
RESEARCH FIELDS
Professor Seppo Tuomi Early Xhosa phonological development; verbal and non-verbal aspects of intercultural communication; assessment of effectiveness and problems of intercultural communication in South African businesses; prevention and treatment of voicedisorders 51
Dr Dale Ogilvy Early sign language development; hearing parents – deaf children interaction; community-based audiology; interpreting issues; child speech and language disorders; including semantic pragmatic disorder Dr Shajila Singh Dysphagia; adultneurology; speechmotor disorders Dr Jacob Semela Brain-stem auditory evoked potentials, auditory reception of telephone transmitted high frequency phonemes in African languages, influence of cultural factors on communication disorders, traditional healers and speech-language and hearing disorders Ms Meryl Glaser Telecommunications for Deaf and deafened people; the linguistic structure of the signed languages; training of sign language elicitors and training in linguistic data encoding techniques; deaf adult literacy Ms Pharyn Sorour Fetal Alcohol Syndrome; developmental language disorders Ms Carol Legg Neurogenic language disorders; cultural speech language pathology Ms Heather Graz Early intervention; paediatric neurology; central auditory processing Ms Lucretia Petersen Ototoxicity in medication for TB; Hearing aids
Clinical Staff Ms Ros Lentin Cleft palate; laryngectomy; voice Ms Ingrid von Bentheim Narrative discourse in persons with aphasia; acute stroke rehabilitaiton; dysphagia Ms Mandy Fisch Interpreting issues in audiological rehabilitation; test instrumentation Ms Shameemah Hassiem Child language disorders; stuttering Ms Faieza Sayed Stuttering; laryngectomy Ms Heather Wilkinson Child language disorders; culturally appropriate testing
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Hain, T.C., Burnett, T.A., Kiran, S., Larson, C.R., Singh, S. & Kenney, M. 2000. Instructing subjects to make a voluntary response reveals the presence of two components to the audio-vocal reflex. Experimental Brain Research 130: 133-141. Ogilvy, D., von Bentheim, I., Venter, A., Ulatowska, H. & Penn, C. 2000. Discourse, Aphasia and Dialect in the Western Cape. South African Journal of Communication Disorders, Special Edition.
CHAPTERS IN BOOKS
Penn, C., Venter, A. & Ogilvy, D. 2000. Aphasia in Afrikaans: A Preliminary Analysis. In Paradis, M. (ed.) Aphasia in Multilingual Populations.
PUBLISHED CONFERENCE PROCEEDINGS
Brewis, S. & Tuomi, S. 2000. Perceptions of Intercultural Communications in a South African Business Organization. Speech Pathology Australia National Conference, Adelaide, Australia, 171-180. Glaser, M. & Aarons, D.A. 2000. Deaf Adults who want to read and write. In CD Proceedings International 19th Congress on Deaf Education (ICED), Sydney, Australia.
52
Glaser, M.A. 2000. Field Trial and Evaluation of Telkom’s Teldem Terminal in a Deaf Community in the Western Cape. In CD Proceedings of South Africa Telecommunication and Network Access Conference (SATNAC), Somerset West. Kinsella, A. & Ogilvy, D. 2000. Developmental Limb Apraxia in Deaf Children: An Objective Assessment. Speech Pathology Australia National Conference. Adelaide, Australia, 266-275.
CONFERENCE ABSTRACTS Brewis, S. & Tuomi, S. 2000. Perceptions of Intercultural Communications in a South African Business Organization. Poster presentation to the Second International Symposium on Communication Disorders in Multilingual Populations, Kwa Maritane, South Africa. Fagan, J., Lentin, R., Oyarzabal, M., Isaacs, M. & Sellars, S. 2000. Tracheo-Oesophageal Speech at Groote Schuur Hospital: Implications for patient and valve selection in the developing world. Oral presentation to the Surgical Research Society 2000 Meeting, Cape Town, South Africa. Glaser, M. 2000. Deaf Adults who want to read and write. Oral presentation to the International Conference on Deaf Education (ICED), Sydney, Australia. Glaser, M. 2000. The written English skills of Deaf adults who use South African Sign Language (SASL) Poster presentation to 7th International Theoretical Issues in Sign Language Research (TISLR) Conference, Amsterdam, Netherlands. Israel, A. & Ogilvy, D. 2000. Hierarchical Discourse Therapy: A Mode of Intervention for Mildly, Cognitively-Communicatively Impaired Patients. Poster presentation to the 9th International Aphasiology Conference, Rotterdam, Netherlands. Madden, S. & Ogilvy, D. 2000. Assessment of Communicative Skills in Deaf Signing Children of Hearing Parents. Oral Presentation to the 7th International Theoretical Issues in Sign Language Research (TISLR) Conference, Amsterdam, Netherlands. Ogilvy, D. 2000. The Assessment of Communicative Skills in Children with Pervasive Developmental Disorders. Oral presentation to the Institute of Child Health, University of Cape Town. Ogilvy, D., Penn, C. & Commeford, A. 2000. Assessment of Linguistic and Cognitive Functions in the Learning Disabled Deaf Signers. Oral presentation to the 7th International Theoretical Issues in Sign Language Research (TLSIR) Conference, Amsterdam, Netherlands. Ogilvy, D. & Evans, M. 2000. The Communicative, Interpersonal and Therapeutic Dynamics of the Audiologist-Interpreter-Caregiver Triad in Interpreted Consultations. Oral Presentation to the Institute of Child Health, University of Cape Town. Ogilvy, D., Von Bentheim, I., Venter, A., Penn, C. & Ulatowska, H. 2000. Cultural and linguistic factors in linguistic factors: “because why?”. Oral presentation to the Second International Symposium on Communication Disorders in Multilingual Populations, Kwa Maritane, South Africa. Pascoe, M.D. & Tuomi, S. 2000. Segmental Phonology and Black South African English Speakers: Communicative Success with Standard Dialect Listeners. Poster presentation to the Second International Symposium on Communication Disorders in Multilingual Populations, Kwa Maritane, South Africa. Semela, J.M. 2000. The significance of cultural variables in diagnostic assessment and therapy. Oral presentation to the Second International Symposium on Communication Disorders in Multilingual Populations, Kwa Maritane, South Africa. Von Bentheim, I. & Venter, A. 2000. Cultural factors influencing tasks in discourse assessment. Oral presentation to the Second International Symposium on Communication Disorders in Multilingual Populations, Kwa Maritane, South Africa.
THESES AND DISSERTATIONS PASSED FOR HIGHER DEGREES Von Bentheim, I. 2000. Narrative Discourse in English Speaking Coloured Persons with Aphasia and Normal Controls in the Western Cape, South Africa: 1-127. Masters Dissertation, University of Cape Town. Fonarov, I. 2000. Narrative Discourse in Language Impaired Learning Disabled Pre-Adolescents. Masters Dissertation, University of Cape Town. Pascoe, M. 2000. Segmental Phonology and Black African English Speakers: Communicative Success with Standard Dialect Listeners: 1-97. Masters Dissertation, University of Cape Town.
CONSULTANCY AND OTHER ACTIVITIES BASED ON EXPERTISE DEVELOPED IN RESEARCH Glaser, M. 2000. World Federation of the Deaf (WFD) Nominated by Deaf SA and appointed expert on Audiology and telecommunication for 3 year term 2000 – 2003. Ogilvy, D. 2000. Western Cape Education Department, ELSEN, Policy and Admission Criteria.
53
DEPARTMENT OF MEDICAL BIOCHEMISTRY (Including the Research and Development Unit of Ribotech, a subsidiary of Bioclones PTY Ltd. and the CANSA/MRC Oesophageal Cancer Research Group)
HEAD OF DEPARTMENT: Professor M. Iqbal Parker
DEPARTMENTAL CONTACT DETAILS
Postal address: Department of Medical Biochemistry University of Cape Town Faculty of Health Sciences Anzio Road Observatory 7925 South Africa Telephone: SA (21) 406-6335 Fax: SA (21) 447-7669 e-mail: [email protected]
DEPARTMENTAL PROFILE
The Department of Medical Biochemistry is a preclinical, basic science department in the UCT Faculty of Health Sciences. Our principal functions are teaching and research. Undergraduate teaching is in medical biochemistry to first-year MBChB students and in physiology and medical biochemistry (jointly with the Department of Physiology) to second-year MBChB students. Postgraduate teaching includes a vigorous Honours course (jointly with the Department of Chemical Pathology) and MSc and PhD programmes. Our research activities fall into 4 major areas: (1) Regulation of collagen gene expression; (2) proteolytic processing of membrane proteins; (3) cellular and molecular biology of breast and oesophageal cancer; (4) endocytic processing with particular emphasis on mechanisms for intracellular survival of mycobacteria; (5) molecular reproductive endocrinology. In addition, the affiliated Ribotech Unit is developing the use of double-stranded RNA as interferon-inducing antiviral agents. The Department also houses the Oesophageal Cancer Research Group funded by the MRC and the Cancer Association of S.A. The Group includes researchers from UCT, UNITRA, Stellenbosch, Pretoria, UWC and the Free State, with Professor Parker as the Director. Professor Parker has also been awarded a U.N.E.S.C.O. Molecular and Cell Biology Network laboratory which allows access of UNESCO funds for training of scientists from developing countries. Professor Thilo has ongoing collaborations on mycobacterial research with groups in France and Germany. Dr Arieh Katz and his group joined the Department in January 1999. He still has a very active collaboration with Professor Millar who is currently Director of the MRC Reproductive Biology Unit in the United Kingdom.
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG TERM HONORARY STAFF CONTRACT STAFF Professors 1 Honorary Senior Lecturers 2 Associate Professors 1 TOTAL 2 Senior-Lecturers 1 Research Staff 4 STUDENTS Post-doctoral Fellows 4 Administrative and Clerical Staff 2 Doctoral 10 TOTAL 13 Masters 6 Honours 5 Undergraduate 374 TOTAL 395
54
RESEARCH FIELDS
PERMANENT STAFF
Professor M Iqbal Parker Acting Head of Department and Chair of Cancer Research; Research interests include cellular and molecular biology breast and oesophageal cancer; collagen gene regulation A/Professor Lutz Thilo Research interests: Endocytic and membrane trafficking; mycobacterial phagosomes Dr Cynthia Sikakana Senior Lecturer; research interests: drug and xenobiotic metabolism
HONORARY STAFF
Professor R.P.Millar Honorary Professor – Director of MRC Reproductive Biology Unit, Edinburg, UK and collaborates with Dr Arieh Katz Dr A Katz Wellcome Senior Fellow, Honorary Senior Lecturer; Molecular Reproductive Endocrinology Dr Edward Sturrock Honorary Senior Lecturer; Structure/function studies on angiotensin-converting enzymes
SCIENTIFIC OFFICERS
Dr Tommy Haylett Research Officer; endocytic processing Sylva Schwager Senior Scientific Officer; proteolytic processing of membrane proteins Erin Dietzsch Scientific Officer; mutations in oesophageal cancer
POST-DOCTORAL FELLOWS
Dr Robea Ballo Identification of genes involved in susceptibility to oesophageal cancer Dr B Troskie Cloning of the GnRH receptor
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Woodman, Z.L., Oppong, S.Y., Cook, S., Hooper, N.M., Schwager, S.L.U., Brandt, W.F., Ehlers, M.R.W. & Sturrock, E.D. 2000. Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared to testis ACE despite cleavage at identical stalk sites. Biochemistry Journal 347: 711-718. King, J.A., Fidler, A., Lawrence, S., Adam, T., Millar, R.P. & Katz, A. 2000. Cloning and expression, pharmacological characterisation and internalisation kinetics of the pituitary GnRH receptor in a metatherian species of mammal. General and Comparative Endocrinology 117:439-448. Conklin, D., Rixon, M.W., Kuestner, R.E., Maurer, M.F., Whitmore, T.E. & Millar, R. 2000. Cloning and gene expression of a novel human ribonucleoprotein. Biochemica and Biophysica Acta 1492: 465-469. Troskie, B.E., Hapgood, J.P., Millar, R.P. & Illing, N. 2000. cDNA cloning, gene expression and ligand selectivity of a novel GnRH receptor expressed in the pituitary and midbrain of Xenopus laevis. Endocrinology 141: 1764-1771. Yoo, M.S. Kang, H.M., Choi, H.S., Kim, J.W., Troskie, B.E., Millar, R.P. & Kwon, H.B. 2000. Molecular cloning, distribution and pharmacological characterization of a novel gonadotropin- releasing hormone ([Trp8] GnRH) in frog brain. Molecular and Cellular Endocrinology 164: 197- 204.
55
Conklin, D., Yee, D.P., Millar, R., Engelbrecht, J. & Vissing, H. 2000. Mining of assembled expressed sequence tag (EST) data for protein families: application to the G-protein coupled receptor superfamily. Briefings in Bioinformatics 1: 93-99.
THESES PASSED FOR HIGHER DEGREES
Donninger, H. 2000. Gene Mutations and Expression in Breast Cancer. Ph.D. thesis, University of Cape Town. Dave, J. 2000. Identification and characterisation of proteases in Mycobacterium tuberculosis. Ph.D. thesis, University of Cape Town. Lopes, J. 2000. The role of the chicken gonadotropin-releasing hormone receptor C-terminal tail in expression and coupling. M.Sc. dissertation, University of Cape Town.
INTERNATIONAL CONFERENCES ATTENDED
Sturrock, E.D. 2000. Gordon Research Conference on Proteolytic Enzymes and their Inhibitors. Parker, M.I. 2000. Gave oral presentations at the following congresses: Sixteenth South African Society of Biochemistry and Molecular Biology (SASBMB) Grahamstown. Third Federation of African Societies of Biochemistry and Molecular Biology (FASBMB), Cairo, Egypt. Eighteenth International Union of Biochemistry and Molecular Biology (IUBMB), Birmingham, UK – attended the IUBMB Executive Committee meeting.
56
DEPARTMENT OF MEDICAL MICROBIOLOGY
HEAD OF DEPARTMENT – Professor Lafras M Steyn
DEPARTMENTAL CONTACT DETAILS
Postal address: Department of Medical Microbiology University of Cape Town, Medical School Anzio Road Observatory 7925 South Africa Telephone: SA (21) 406-6363 Fax: SA (21) 448-8153 e-mail: [email protected] Website: http://www.uct.a c.za/depts/mmi/index.html
DEPARTMENTAL PROFILE
The department consists of Microbiology and Virology sections. Members of each section provide diagnostic services, undergraduate and postgraduate medical student training, conduct research and provide training for science students interested in a research career.
The composition of the Department is complex with staff drawn from the University of Cape Town, Groote Schuur Hospital, Red Cross Children’s Hospital and the South African Institute of Medical Research. The microbiology diagnostic laboratories are located at the two hospitals, while the virology diagnostic laboratories are located on the Medical School Campus in the Wernher & Beit Building (North). This is also the site of the molecular research laboratories.
Aside from providing a full range of diagnostic services, the department is involved in clinical and diagnostic trials, investigating outbreaks of infection, and in defining the epidemiology of various infectious agents. Important areas of research focus on the Human Immunodeficiency Virus, tuberculosis, hepatitis virus, bacterial antibiotic resistance, human papilloma viruses, and nosocomial pathogenes. A major effort is directed into developing novel vaccines and vaccine vectors. The department also has a frequently accessed site on the World Wide Web.
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG HONORARY STAFF STUDENTS TERM CONTRACT STAFF
Professors 2 Honorary Lecturers 8 Post-Doctoral 6 Associate Professors 2 TOTAL 8 Registrars 4 Senior Lecturers 6 Doctoral 10 Lecturers 2 Masters 11 Research Staff 13 Honours 7 Technical Support Staff 14 Undergraduate 176 Administrative and Clerical Staff 4 TOTAL 214 TOTAL 43
57
RESEARCH FIELDS
PERMANENT STAFF
Professor Lafras M Steyn Molecular biology of mycobacterium tuberculosis Professor Girish Kotwal Immunevasion by microorganisms Assoc. Prof. Albert Lastovica Campylobacter and Helicobacter Assoc. Prof. Anna-Lise Williamson Human Papillomaviruses , HIV-1 vaccine development Dr Gay Elisha Antibiotic resistance mechanisms & molecular epidemiology Dr Di Hardie Molecular biology of Hepatitis B Virus - management of diagnostics viral lab Dr Anthony Keen Management of diagnostic virology laboratories; HIV epidemiology Dr Steve Oliver Infection control policies and antibiotic usage Dr Denise Roditi Clinical antibiotic usage and infection control; Clinical trials Dr Linda Stannard Electron microscopy of viruses Dr Jane Yeats Management of diagnostic virology laboratories; Parvovirus B19
REGISTRARS JOINT APPOINTMENTS
Dr Lydia Altini Opportunity infectious in HIV/AIDS Dr Sabina Ernsting Paediatric microbiology Dr Tim Tucker Hepatitis viruses Dr Andrew Whitelaw Molecular diagnostics
HONORARY STAFF
Dr Heinrich Hoppe Protozoan parasites Dr W Katz Vaccine production Dr D Mehtar Infection control Dr Mike Renan Oncogenesis Dr Johnny Sachs Vaccine development Dr J Simpson Clinical microbiology Dr H Smuts Hepatitis C Dr C Williamson HIV molecular biology
CONTRACT RESEARCH STAFF
Dr Linda-Gail Bekker Immunopathogenesis of tuberculosis Dr Ros Chapman Mycobacterial stress responses 58
Dr Di Marais Human papillomavirus immunology Dr Jenny Ramesar Human papillomavirus typing Mr Bruce Allan Diagnosis of human papillomavirus Mrs Kate Aspden Development of recombinant poxy virus-rabies virus vaccine Mr Jandre Grobler HIV Mrs Patty Kay Human papillomavirus vaccine project Mr Shayne Loubser HIV Mr Lucky Malaza HIV Mr Peter Owira HIV Ms Nicole Pahl Human Papillomavirus Mr Fritz Tiedt Election microscopy of recurring recombinant proteins
DISTINGUISHED VISITORS
Gilbert Carnathan International Aids Vaccine Initiative Wayne Koff International Aids Vaccine Initiative Dr W Prozesky SAAVI – MRC Cape Town Gerard T Sanders Academic Medical Centre – University of Amsterdam Prof. S.A. Tswana Department of Medical Microbiology – University of Zimbabwe, Harare Prof. N.A.M. Urbanus Academic Medical Centre – University of Amsterdam Jan C van den Boer Roche Diagnostics – Netherlands
POST –DOCTORAL FELLOWS
Dr William Bourn HIV Dr Ros Chapman Mycobacterial stress responses Dr Vandana Govan HPV Dr Jo-Ann Passmore HPV Dr Karen Shires Coldshock in mycobacteria Dr Joanne van Harmelen HIV
RESEARCH OUTPUTS
RESEARCH PAPERS
Bekker, L.G., Haslett, P., Maartens, G., Steyn, L. & Kaplan, G. 2000. Thalidomide-induced antigen- specific immune stimulation in patients with HIV-1 and tuberculosis. Journal of Infectious Diseases 181:954 - 965.
59
Karlshev, A.V., Linton, D., Gregson, N.A., Lastovica, A.J. & Wren, B.W. 2000. Identification of high molecular weight lipopolysaccharide of C jejuni as type II capsular polysaccharide: genetic and biochemical evidence. Molecular Microbiology 35: 529-541. Marais, D,.J., Rose, R.C., Lane, C., Kay, P., Nevin, J., Denny, L., Soeters, R., Dehaeck, C.M. & Williamson, A.L. 2000. Seroresponses to human papillomavirus types 16, 18, 31, 33 and 45 virus-like particles in South African women with cervical cancer and cervical intraepithelial neoplasia. Journal of Medical Virology 60(4): 403-410. Marais, D..J., Rose, R.C., Lane, C., Aspinall, S., Bos, P. & Williamson, A-L. 2000. Seroresponses to virus-like particles of human papillomavirus types 16, 18, 31, 33 and 45 in San people of Southern Africa. Journal of Medical Virology 60(3): 331-336. Marais, D..J., Vardas, E., Ramjee, G., Allan, B., Kay, P., Rose, R.C. & Williamson, A-L. 2000. The impact of Human Immunodeficiency Virus Type 1 Status on Human Papillomavirus (HPV) Prevalence and HPV Antibodies in Serum and Cervical Secretions. Journal of Infectious Diseases 182(4): 1239-1242. Osborn, A.M., Da Silva Tatley, F.M., Steyn, L.M., Pickup, R.W. & Saunders, J. 2000. R. Mosaic plasmids and mosaic replicons: evolutionary lessons from the analysis of genetic in InFll-related replicons. Microbiology 146: 2267-2275. Tucker, T.J. & Smuts, H.E.M. 2000. GBV-C/HGV Genotpyes: Proposed Nomenclature for Genotypes 1-5. Journal of Medical Virology 62: 82-83. Tucker, T.J., Smuts, H.E.M., Eedes, C., Knobel, D., Eickhaus, P., Robson, R.E. & Kirsch, R.E. 2000. Evidence that GBV-C/Hepatitis G Virus is primarily a Lymphotropic Virus. Journal of Medical Virology 61(1):52-58. Van der Riet, F. De St J. 2000. Diseases of plants transmissible between plants and man (Phytonoses) exist – follow-up. Medical Hypotheses 54(2): 310-311. Van der Riet, F. De St J. & Renan, M.J. 2000. How infections with non-retroviral RNA viruses may be involved in the development of neoplasia. Medical Hypothesis 55(2): 109-113. Wassenar, T.M., Lastovica, A.J., Duim, B., Wagenaar, J.A., Coole, P.J. & Fry, B.N. 2000. Genetic characterization of Campylobacter jejuni 0:41 isolates in relation with Guillan-Barre syndrome. Journal of Clinical Microbiology 38: 874-876. Williamson, C., Loubser, A.S., Brice, G., Joubert, T., Smit, R., Thomas, R., Visagie, M., Cooper, M. & van der Ryst, M. 2000. Allelic frequencies of host genetic variants influencing susceptibility to HIV-1 infection and disease in South African Populations. 14 (4):449-451. Williamson, C., Morris, L., Rybicki, E. & Williamson, A-L. 2000. Designing HIV-1 subtype C vaccines for South Africa. South African Journal of Science 96: 318-324.
RESEARCH LETTER
Lastovica, A.J. & Le Roux, E. 2000. Efficient isolation of campylobacteria from stools. Journal of Clinical Microbiology 38:2798-2799.
EDITORIAL/LETTER Rybicki, E., Williamson, A-L. & Morris, L. 2000. AIDS dissidents aren’t victims - but the people their ideas kill will be. Nature 18: 405(6784):273.
CONFERENCES/MEETINGS PROCEEDINGS
Kidd, M., Lastovica, A.J., Pere-Perez, G., Tang, L.H., Modlin, I.M. & Louw, J.A. 2000. The biological relevance of Helicobacter pylori virulence fingerprints. Southern African Gastroenterological Society meeting, Windhoek. South African Medical Journal 90: 643. Kidd, M., Peek, R.M., Lastovica, A.J., Kummer, A.F. & Louw, J.A. 2000. Relationship between Helicobacter pylori iceA genotypes, vacA alleles and clinically significant disease in South Africa. Southern African Gastroenterological Society meeting, Windhoek. South African Medical Journal 90: 637. Kummer, A.F., Kidd, M., Kotze, U., Taylor, K., Lastovica, A.J. & Louw, J.A. 2000. Relationship between gastric adenocarcinoma 9GAC) and H.pylori (HP): A case-control study. Southern African Gastroenterological Society meeting, Windhoek. South African Medical Journal 90: 637. Lastovica, A.J. & Engel, M.E. 2000. Campylobacter concisus: pathogen or comensal? Results of a five year study of paediatric patients in South Africa. 100th Annual American Society of Microbiology meeting in Los Angeles, CA.
60
Lastovica, A.J. & Engel, M.E. 2000. The epidemiology of other Campylobacter species. WHO Consultation on the Increasing Incidence of Campylobacteriosis in humans, Copenhagen, Denmark. Steyn, L.M. 2000. Rockefeller Foundation Meeting on Tuberculosis Drug Development (Somerset West). Association of Pathologists for East, Central and southern Africa (APECSA) invited speaker, Victoria Falls, Zimbabwe. Secure the Future, TB/HIV Working Group Meeting. Tucker, T.J. 2000. African Associaton for the study of Liver Disease. Hepatitis A and E; Epidemiology, Clinical Syndromes and Vaccination, Sun City, South Africa. Williamson, A.L. 2000. Escherichia coli heat-labile enterotoxin mutant LT(R192G) and CpG DNA act as potent mucosal adjuvants for oral delivery of human papillomavirus virus-like particles. 18th International Papillomavirus & HPV Clinical Workshop jointly with the 12th Meeting of the AEPCC, Barcelona, Spain. Williamson, A.L. 2000. Human papillomavirus-specific immunity induced following immunization with recombinant mycobacterium bovis bacille calmette-guérin (BCG) expressing HPV-16 L1 protein. 18th International Papillomavirus Conference & HPV Clinical Workshop jointly with the 12th Meeting of the AEPCC, Barcelona, Spain. Williamson, A.L. & Marais, D. 2000. Oral and cerivcal mucosal antibodies to human papillomavirus type 16 in women with cervical neoplasia. 18th International Papillomavirus Conference & HPV Clinical Workshop jointly with the 12th Meeting of the AEPCC, Barcelona, Spain. Williamson, A.L. & Marais, D. 2000. The impact of human immunodeficiency virus type 1 status on human papillomavirus prevalence and HPV antibodies in serum and vaginal washes. 18th International Papillomavirus Conference of HPV Clinical Workshop jointly with the 12th Meeting of the AEPCC, Barcelona, Spain. Williamson, C. 2000. Plenary debate – Vaccines for testing in developing countries should always be matched to the dominant local HIV strain/subtype (Db03). International AIDS Conference, Durban. Williamson, C., Swanstrom, R., Morris, L., Thomas, R., Ping, P.H., Pacual, A., Johnston, R.E. & Abdool Karim, S.S. 2000. Selection of a representative HIV-1 subtype C isolate for use in the development of candidate vaccines for Southern Africa. TUOrA415. XIII International AIDS 2000, Durban. Williamson, C. 2000. AIDS Vaccine Development for Africa. Design of VEE Replicon AIDS Vaccine. Roundtable (TuOr46). XIII International AIDS Conference, Durban. Williamson, C. 2000. South African HIV/AIDS Vaccine. Reproductive Health Priorities 2000, Cape Town.
BOOK CHAPTERS
Lastovica, A.J. & Skirrow, M.B. 2000. Clinical Significance of Campylobacter and Related Species other than C. jejuni. In Nachamkin, I. & Blaser, M. (eds) Campylobacter: 89-120. American Society for Microbiology, Washington, D.C.
THESES PASSED FOR HIGHER DEGREES
Bekker, L-G. 2000. Immunotherapy in patients infected with Mycobacterium tuberculosis and HIV. Ph.D. thesis, University of Cape Town. Marais, D. 2000. A study of the immune response to human papillomavirus types causing cervical cancer. Ph.D. thesis, University of Cape Town.
OTHER ACTIVITIES
Steyn, L.M. 2000. External examiner for the MBBS pathology course, University of the West Indies (Camp Hill Campus, Barbados and Mona Campus, Jamaica).
61
DEPARTMENT OF MEDICAL PHYSICS
HEAD OF DEPARTMENT: Dr ER Hering
DEPARTMENTAL CONTACT DETAILS
Postal Address: LC 32, Department of Medical Physics Groote Schuur Hospital Observatory South Africa Telephone: SA (21) 404-6266 Facsimile: SA (21) 404-6269 Email: [email protected]
DEPARTMENTAL PROFILE
The department of Medical Physics is responsible to the Departments of Diagnostic Radiology, Nuclear Medicine and Radiation Oncology for the safe use of ionization radiation, patient dosimetry and treatment, and the optimum use and functioning of equipment. This also includes the training of staff in their departments.
The department is recognised by the HPCSA as a training centre for Medical Physicists. The department has an active postgraduate teaching / research programme.
DEPARTMENTAL STATISTICS
PERMANENT AND LONG TERM HONORARY STAFF
CONTRACT STAFF
Senior Lecturer 1 Honorary Lecturers 1
Lecturers 2 TOTAL 1 TOTAL 3
STUDENTS M.Med. 7
M.Sc. (Med) 3
TOTAL 10
RESEARCH FIELDS
PERMANENT STAFF
Dr ER Hering Head of Department; low dose radiation dosimetry JK Hough Assessment of and Improvements to a Stereophotogrammetric Patient Positioning System for Proton Therapy Mr C. Challens in vivo dosimetry
HONORARY LECTURERS
Mr J. Korrubel Electronics and medical instrumentation
62
RESEARCH OUTPUTS
THESES PASSED FOR HIGHER DEGREES
Bhengu, K.J. 2000. The use of thermoluminescent dosimeters for in-vivo dosimetry in a fast neutron beam: 1-77. M.Sc. (Med) dissertation, University of Cape Town. Hough, J.K. 2000. Assessment of and Improvements to a Stereophotogrammetric Patient Positioning System for Proton Therapy: 1-148. M.Sc. (Med) dissertation, University of Cape Town.
63
DEPARTMENT OF MEDICINE (Incorporating the UCT Bioethics Centre, MRC/UCT Ischaemic Heart Research Unit and the MRC/UCT Liver Research Centre)
HEAD OF DEPARTMENT - Professor RE Kirsch
DEPARTMENTAL CONTACT DETAILS
Postal Address: Department of Medicine University of Cape Town Medical School Observatory 7925 Cape Town Telephone: SA (21) 406-6200 Fax: SA (21) 447-9670 E-mail: [email protected]
DEPARTMENTAL PROFILE
The Department incorporates 3 research Units: the UCT Bioethics Centre, the MRC/UCT Liver Research Centre and the MRC/UCT Ischaemic Heart Disease Research Unit; 14 divisions or clinics: Cardiology, Immunology, Endocrinology and Diabetology, Emergency Medicine, Gastroenterology, Geriatrics, the Hypertension Clinic, Lipidology, Neurology, Nephrology, Nutrition and Dietetics, Pulmonology, and Rheumatology; and Departments of Internal Medicine – at Groote Schuur, Conradie, Jooste, Somerset, and Victoria Hospitals.
DEPARTMENTAL STATISTICS 2000
PERMANENT & LONG TERM HONORARY STAFF CONTRACT STAFF Professors 6 Honorary Professors 1 Associate Professors 15 Emeritus Professor 1 Senior Lecturers 17 Honorary Associate 1 Lecturers 6 Professor Research staff (see units within Honorary Senior 7 Dept) Lecturers
Administrative and clerical staff 9 Honorary Lecturers 4
TOTAL 53 Honorary Research 2
Associates TOTAL 16
STUDENTS Doctoral 12 Masters 110 Undergraduates 516 TOTAL 638
64
RESEARCH FIELDS
See Units and Divisions within the Department
Professor R E Kirsch Medical education, health services, porphyria, hepatitis, infection and liver disease, cardiovascular manifestations of portal hypertension
65
UCT BIOETHICS CENTRE
DIRECTOR – Professor S.R. Benatar
CONTACT DETAILS Postal Address: UCT Bioethics Centre J Floor, OMB Groote Schuur Hospital Observatory, 7925 Cape Town Telephone: SA (21) 406-6115 Fax: SA (21) 448-6815 Email: [email protected] [email protected]
DEPARTMENTAL PROFILE AND SUMMARY
The first Applied Ethics Masters Degree Course in Bioethics (MPhil) was completed at the end of 2000. All five students successfully completed the course work and are working on their dissertations. Terry Fleischer completed his first year with us as a visiting scholar. He has become an active, much sought after and appreciated participant in many of our activities- including teaching in our MPhil programme. He has taken a leading role in our work on resource allocation and priority setting, and is working with Ann Pope in developing a course in 'Law and Medicine' for the Law Faculty.
Professor Benatar spent four months as visiting Professor in the Departments of Public Health Sciences and Medicine at the Joint Bioethics Centre, University of Toronto. He was the Canadian Royal College of Physicians and Surgeons’ McLaughlin-Gallie Visiting Professor for 2000. He serves on the Board of Directors of the International Association for Bioethics, and on the Board of Directors of The Ethics Institute of South Africa.
Dr David Benatar was invited to give a large number of lectures at many venues throughout South Africa. He and Prof S Benatar delivered a five-lecture evening course on medical ethics to a group of almost 100 medical practitioners in Cape Town.
Our consultation service has been used quite extensively and this continues to be offered at several hospitals. In addition, Professor Benatar has provided teaching/consultation sessions each at our community hospitals - once a month at each of Victoria, Jooste, Somerset and Conradie Hospitals.
DEPARTMENTAL PROFILE
In October 2000 the UCT Bioethics Centre Consortium (with colleagues from the Universities of Stellenbosch, Witswatersrand, Natal and Orange Free State) was awarded a Development Grant of $50,000 a year for two years from the US National Institutes of Health's Fogarty International Centre to develop a program for capacity building in Research Ethics in South Africa. The development process will take place in collaboration with the Joint Centre for Bioethics in Toronto.
We have embarked on a series of projects on resource allocation and priority setting under conditions of increasing scarcity of resources at Groote Schuur and the Red Cross Childrens' Hospitals. The first project towards defining a policy for dealing with severe head injuries under conditions of severe resource constraints has been published.
DEPARTMENTAL STATISTICS
PERMANENT AND LONG- HONORARY STAFF STUDENTS
TERM CONTRACT STAFF
Professors 1 Honorary staff 24 M.Phil. Bioethics 5
TOTAL 1 TOTAL 24 TOTAL 5
66
RESEARCH FIELDS
Prof S R Benatar Research Ethics (including International Research Ethics) and Global Bioethics Dr David Benatar Moral Philosophy and Applied Ethics Dr Augustine Shutte African Philosophy and its implications for Bioethics Dr Leslie Henley End of life decisions - with special reference to a children's hospital Dr Paul Roux The impact of informed consent with regard to HIV / AIDS in a children’s hospital Terry Fleischer Resource allocation/priority setting within the context of shrinking resources. Dr Steve Andrews Informed consent in a multicultural setting
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFERREED ARTICLES
Benatar, S.R. & Singer, P.A. 2000. A new look at international research ethics. British Medical Journal 321: 824-826. Benatar, S.R. 2000. Avoiding exploitation in clinical research. Cambridge Quarterly of Healthcare Ethics 9(4): 562-565. Benatar, S.R. 2000. Preventing vertical HIV transmission: the controversy in South Africa. Journal of Women’s Health and Law 1(3): 313-318. Benatar, S.R., Fleischer, T.E., Taylor, A. & Peter, J. 2000. Treatment of head injuries in SA. South African Medical Journal 90: 790-793. Benatar, S.R. 2000. Medical education and medical practice in the 21st century. Brunei Medical Journal 2: 15-16. Benatar, D. 2000. The wrong of wrongful life. American Philosophical Quarterly 37 (2): 175-183. Henley, L.D. & Landman, W.A. 2000. Implementing children’s constitutional healthcare rights fairly. South African Medical Journal 90: 601-604. Landman, W.A. & Henley, L.D. 2000. Rationing and children’s constitutional healthcare rights. South African Journal of Philosophy 19 (1): 41-50. Landman, W.A. & Henley, L.D. 2000. Legalising advance directives in South Africa (editorial). South African Medical Journal 90: 785-787.
BOOKS
Glazewski, J. 2000. Environmental Law in South Africa: 1-911. Durban: Butterworths.
CHAPTERS IN BOOKS
Benatar, S.R. 2000. Human Rights in the Biotechnology Era: A story of two lives and two worlds. In Bhatia, G.S., O’Neil, J.S., Gall, G.L. & Bendin, P.D. (eds) Peace, Justice and Freedom: Human Rights challenges in the new millennium: 245-257. Edmonton: University of Alberta Press.
CONFERENCE ABSTRACTS
Benatar, S.R. 2000. Avoiding conflict in clinical research. 5th World Conference on Bioethics, London, UK.
UNIVERSITY PUBLICATIONS AND WORKS OF A POPULAR NATURE
Benatar, D. 2000. Euthanasia and assisted suicide: the right to life and its corollary. Specialist Medicine 22(6): 354-358. Benatar, S.R. 2000. (Book Review) Clinical Guidelines and the Law by B Hurwitz. South African Medical Journal 90: 123-124. Benatar, S.R. 2000. (Letter) AIDS in the 21st century. New England Journal of Medicine 342: 515-516.
67
Logie, D.E. & Benatar, S.R. 2000. (Letter) Realistic priorities for AIDS control. The Lancet 356: 1525-1526. Benatar, S.R. & Fleischer, T.E. 2000. (Letter) Tough priorities. The Hastings Center Report 30: (5) 4.
CONSULTANCY AND OTHER ACTIVITIES BASED ON EXPERTISE DEVELOPMENT IN RESEARCH
Prof SR Benatar participated as a Committee member/consultant in re-writing the CIOMS International Guidelines on Research Ethics in Geneva. Board of Directors – Ethics Institute of South Africa Board of Trusteers – Groote Schuur Hospital Trust South African Scientific Advisor to the Novartis Foundation, London Elected Member: Committee for Human Rights, Ethics and Professional Practice. Health Professional Council of South Africa Elected Member: Board of Trustees of the International Association of Bioethics Chairman UCT Committee of Ethics of Research Editorial Advisory Board. Journal of Theoretical Medicine and Bioethics Editorial Advisory Board. International Library of Law, Ethics and Medicine Prof S R Benatar gave three invited presentations at the AIDS 2000 Conference in Durban. He presented invited papers at the Hastings Center Meeting on 'Medicine and the Market,' and at a plenary session of the 5th World Congress of Bioethics in London. He gave an invited keynote address at the Scientific Meeting of the Swiss Society of Public Health in Bern, in honour of Prof theodore Abelin’s retirement. Prof SR Benatar gave an invited presentation at a Colorectal Cancer Symposium in Cape Town. Prof T Zabow gave presentations at the International Conference on Ethics in Medical Education In Israel, and at the 13th World Congress of Medical Law in Helsinki. Prof T Zabow gave presentations at the 11th National Congress of Psychiatry in Durban and at a Conference on the Impaired Health Professional and Student Health Professions Council of South Africa in Cape Town Prof J Glazewski presented at the Annual Conference of the South African Teachers of Law in Durban. Mr Terry Fleischer gave a presentation at the meeting of the Neurosurgeon’s Society of South Africa, in Cape Town.
68
CARDIAC CLINIC
HEAD OF DEPARTMENT - Professor P J Commerford
CONTACT DETAILS Postal Address: The Cardiac Clinic E25 Groote Schuur Hospital Observatory 7925 Cape Town Telephone: SA (21) 404-6084 Fax: SA (21) 448-7062 Email: [email protected]
DEPARTMENTAL PROFILE
The Cardiac Clinic provides an in- and outpatient clinical service in cardiology and training for registrars in the subspeciality. Research activities are predominantly clinical including evaluation of new pharmaceutical agents and adaptations of practice to suit local conditions.
DEPARTMENTAL STATISTICS
PERMANENT AND LONG TERM STUDENTS CONTRACT STAFF Professor 1 Learner Technologists 2 Associate Professor 1 TOTAL 2 Senior Lecturers 3 Part-time Senior Lecturer 1 Registrars-in-training 3 Secretarial and Research Staff 4 Technologists 4 ECG Technicians 8 Honorary Staff 1 Nursing Staff 33 radiographers 4 GSH Administrative 6
TOTAL 69
RESEARCH FIELDS
Professor Patrick J Commerford VAL-HEFT Study. A placebo-controlled trial to assess the effect of Valsartan on morbidity and mortality in patients with stable, chronic, congestive heart failure; a4-year, double-blind, randomized, placebo-controlled study of atorvastatin as prevention of CHD end points in patients with (Type II) Noninsulin-dependent diabetes mellitus,Parke-Davis Pharmaceuticals; mocardial ischaemic reduction with aggressive cholesterol lowering (MIRACL) with atorvastatin patients with unstable angina or non-Q wave myocardial infarction, Parke-Davis Pharmaceuticals; CURE: Clopidogrel in unstable angina to prevent recurrent ischaemic events (oasis-4) - protocol no. efc3307a phase iii randomized, double blind, parallel group clinical trial of clopidogrel versus placebo in patients with an acute coronary syndrome (unstable angina or myocardial infarction without st segment elevation) (International Steering Committee); Candesartan Cilexetil (Candesartan) in heart failure assessment of reduction in mortality and morbidity (CHARM) clinical study no: sh-ahs-0003, sh-ahs-0006 and sh-ahs-0007; INTER-HEART – an international multicentre case control study to identify the risk factors for acute myocardial infarction in different ethnic populations. (International Steering Committee); GUSTO IV AMI – Protocol co116t31. A phase iii, randomised, open-label trial evaluating the efficacy and safety of reopro (abciximab) in combination with reduced dose retavase/rapilysin (recombinant plasminogen activator, reteplase, r-pa) for the treatment of acute myocardial infarction; OVERTURE - Protocol no. cv 137-068. omapatrilat versus enalapril randomized trial of utility in reducing events (overture); EPLERENONE: Clinical protocol for a double-blind, randomised, placebo-controlled trial evaluating the safety and efficacy of eplerenone in patients with heart failure following acute myocardial infarction, ind #51,780 69
Professor R N Scott Millar 1998 Survey of cardiac pacing in South Africa. Report of working group of the Cardiac Arrhythmia Society of South Africa (CASSA); Nationwide survey of indications, methods and demographics of pacemaker implantation M Le Roux, Dr A Okreglicki, Professor R N Scott Millar Evaluation of the performance of different bipolar pacing leads. Retrospective analysis of the performance of 3 different bipolar pacing electrodes; Peri-operative ventricular tachyarrhythmias: outcome after ICD implant Professor U von Oppell, Professor RN Scott Millar Surgery for ventricular tachycardia, Review of GSH experience of surgery for ventricular arrhythmias Dr A Okreglicki, Dr T Pillay, Professor R N Scott Millar Review of experience with Wolff-Parkinson-White Syndrome over 12 years, Groote Schuur Hospital A Okreglicki, DT Huang, JP Daubert Longer term analysis of atrial pacing leads with regard to lead position and measured farfield ventricular signals A Okreglicki, JP Daubert, EA O’Gorman, B Delpapa, M Petrini Biventricular pacing in congestive heart failure (chf) - Is it a feasible therapeutic option in a tertiary level state hospital? A Okreglicki & T Pillay CURE STUDY (clopidogrel in unstable angina to reduce recurrent events), Investigator Dr B N Levetan Senior Lecturer; PRESTO STUDY (Prevention of restenosis with tranilast and its outcomes: a placebo-controlled trial), Investigator
DISTINGUISHED VISITORS
Dr Donna Stewart University of Toronto, Canada Professor Bernard J Gersh Mayo Clinic, Rochester, USA Professor Shah Ebrahim, Dr William Hood, Dr Karen Rees, Dr Juliet Manyemba, Dr Antoinette Cilliers, Professor Enoch Kwizera, Ms Theresa Moore, Mrs Margaret Burke The Cochrane Collaboration Team – UK and USA Professor J V Nixon Virginia Commonwealth University, Virginia, USA
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Garner, P., Gelband, H., Olliaro, P., Salinas, R., Volmink, J. & Wilkinson, D. 2000. Available in The Cochrane Library (database on disk and CDROM). The Cochrane Collaboration; Issue 4. Oxford. Mayosi, B.M. & Scott Millar, R.N. 2000. Letter to the Editor. East African Medical Journal 77(6): 339. Meinert, D. & Mohammed, Z. 2000. MRI of congenital coronary artery aneurysm (case report). British Journal of Radiology 73: 322-324. St Clair Gibson, A., Perold, J., Watermeyer, G.A., Latouf, S.E., Hawley, J.A., Lambert, M.I. & Noakes T.D. 2000. Veteran athletes exercise at higher maximum heart rates than are achieved during standard exercise (stress) testing. South African Medical Journal 90(2): 141-146. Update Software; 1997. Updated quarterly. Von Oppell, U., Stemmet, F., Brink, J., Commerford, P.J. & Heijke, S.A.M. 2000. Ischemic mitral valve repair surgery. Journal of Heart Valve Disease 9(1): 64-74.
CHAPTER IN BOOKS
Brice, E.A.W. & Commerford, P.J. 2000. Rheumatic valve disease. In Rosendorff, C. (ed.) Essential Cardiology. Section VII: 561-582. Philadelphia: WB Saunders Co: Philadelphia.
70
LETTERS
Okreglicki, A.M. 2000. P Terminal force in lead V1. American Journal of Cardiology 86(2): 255. Okreglicki, A.M. & Scott Millar, R. 2000. Letter to the Editor Ebstein’s anomaly. PACE Part 1, November.
PUBLISHED CONFERENCE PROCEEDINGS
Mayosi, B.M., Lombard, C. & Mbewu, A.D. 2000. The impact of lp(a) level and apo(a) isoform on left ventricular function following acute myocardial infarction. European Heart Journal 21: 601. Mayosi, B.M., Lombard, C. & Mbewu, A.D. 2000. A prospective study of the effect of lipoprotein(a) level and apolipoprotein(a) isoform on left ventricular damage following acute myocardial infarction. Circulation 102(18): Suppl II, 280.
CONSULTANCY AND OTHER ACTIVITIES BASED ON EXPERTISE DEVELOPED IN RESEARCH
Professor Commerford served on the International Steering Committee of OASIS-2, 3 and 4 and the Organising Committee of INTERHEART, a multinational investigation of inter-ethnic variation in risk factors for acute myocardial infarction (Canadian Cardiovascular Collaboration.)
71
CLINICAL IMMUNOLOGY LABORATORY
HEAD OF UNIT – Associate Professor SR Ress
CONTACT DETAILS
Postal Address: Clinical Immunology Laboratory H47 Old Main Building Groote Schuur Hospital Observatory, 7925 Cape Town Telephone: SA (21) 406-6201 Fax: SA (21) 448-6815 Email: [email protected]
DEPARTMENTAL PROFILE
Clinical immunology laboratory provides a comprehensive diagnostic service to Groote Schuur and related teaching hospitals, including specialised investigations for the evaluation of immune function in patients with suspected immune deficiency. Research activities comprise the evaluation of cellular immunity in tuberculosis and lipid mediated inflammation. TB basic research evaluates protective immunity of cytotoxic T-cell activity, while collaborative studies are in progress on BCG vaccination (ICH, UCT)) and response to therapy (pharmacology UCT). Collaborative research on the role of monocytes in inducing inflammation and atheroma is undertaken with the Lipid Unit, Dept of Medicine.
STATISTICS
PERMANENT AND LONG- TERM STAFF Associate Professors 1 Research Staff 2 Laboratory Technical 2 Officer Technical Support 2 Staff TOTAL 7
RESEARCH FIELDS
Professor Stanley Ress Immunology of Lipid disorders and tuberculosis Dr MM Keraan Immunology of Lipid disorders and tuberculosis M Watkins (MSc): Immunology of TB PL Semple (MSc): Immunology of TB and lipid disorders
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Hendricks, A.S., Hunter, A.J, Keraan, M. & Blekkenhorst, G.H. 2000. Effects of low dose irradiation on TK 6 and U937 cells: induction of p53 and its role in cell cycle delay and the adaptive response. International Journal of Radiation Biology 76: 11-21.
72
DOCTORAL THESIS PASSED FOR HIGHER DEGREES
Glashoff, R.H. 2000. Characterisation of cytolytic CD4+ and suppressor CD8+ activity of T lymphocyte clones derived from tuberculous pleuritis: 1-174. Ph.D. thesis, University of Cape Town.
CONSULTANCY AND OTHER ACTIVITIES BASED ON EXPERTISE DEVELOPED IN RESEARCH
Professor Ress was invited to attend a WHO workshop in Washington DC in May 2000 on "correlates of immune protection in tuberculosis", and presented research data at the meeting.
73
ENDOCRINE/DIABETES UNIT
HEAD OF DIABETES UNIT - Professor F. Bonnici HEAD OF ENDOCRINE UNIT- Associate Professor N S Levitt
CONTACT DETAILS
Postal Address: The Endocrine/Diabetes Unit Department of Medicine Faculty of Health Sciences Observatory, 7925 Cape Town Telephone: SA (21) 406-6140 Fax: SA (21) 448-6815 E-mail: [email protected]
DEPARTMENTAL PROFILE
During the past year the headships of the combined unit have been separated although there continues to be considerable overlap in areas of interest including research. The Endocrine/Diabetes Unit provides comprehensive clinical and laboratory services to the UCT Teaching Hospital Group, an educational training programme for under- and post-graduate students and fulfils a broad spectrum of research activities.
The Endocrine Unit is actively engaged in research in osteoporosis, adrenal disorders, diabetes and the foetal origins of chronic diseases. International, national and intra-institutional collaborations have been established with the Universities of Edinburgh, Cambridge, Newcastle, British Columbia, the South African Medical Research Council and within UCT, with the departments of Chemical pathology and Neonatology and the Sports Science Institute. This research has focussed on the epidemiology of diabetes and its complications, the prevention of diabetic complications, genetics of diabetes, diabetes health systems research, polycystic ovarian syndrome, mechanisms underlying the association between low birth weight and adult onset chronic disorders, newer tests for the evaluation of adrenal disorders and pharmacological trials in osteoporosis and diabetes. The Endocrine unit and its collaborators have been the recipients of major grants from the Nestle Foundation and the Medical Research Council.
The Diabetes Unit, is instituting a Young Adult's programme as a natural extension of its already successful Adolescent Transition Care. Research is focusing on intensification of metabolic control with new insulin regimes, long-term psychosocial integration and immunotherapy for the prevention of type 1 diabetes. A phase 1 study, investigating the pharmacokinetic and immune responses to an altered peptide ligand in young volunteer subjects with type 1 diabetes, inaugurated the new premises of the Pharmacokinetic Unit at the Lung Institute.
With the help of the Phumeza Mawonga Diabetes Fund, supported by UCT, the SA Diabetes Association and the corporate pharmaceutical sector, novel avenues of cultural, religious and social self- expression are being explored and evaluated as a means of promoting diabetes awareness, self- management and social upliftment in the African communities of Cape Town.
UNIT STATISTICS
PERMANENT AND LONG TERM STAFF Full Professor 1 Associate Professor 1 Senior Lecturers 2 Senior Registrar in training 1 Technical Support Staff 2 Administrative and Clerical 1 Staff TOTAL 8
74
RESEARCH FIELDS
Professor F Bonnici Head of Diabetes Unit; Genetic and molecular studies in growth hormone disorders; phase 4 insulin analogue studies in type 1 and 2 diabetes; phase 1 pharmacokinetic and immune response studies of an altered peptide ligand in the prevention of type 1 diabetes Associate Professor N S Levitt Head of Endocrine Unit; Diabetes and hypertension health systems research; genetics of diabetes, mechanisms for and prevention of complications of diabetes; the foetal origins of chronic diseases; the glycaemic index of foods and pharmaceutical trials in the management of diabetes Dr B Ascott-Evans Osteoporosis; drug research with bisphosphonates; treatment of type 2 diabetes using novel insulin secretagogues, and insulin analogues Dr S Soule Diagnostic tests for the evaluation of Primary hyperaldosteronism; evaluation of adrenal function; pharmaceutical trials in the management of dyslipidaemia, diabetes and osteoporosis
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Coetzee, E. & Levitt, N.S. 2000. Maternal diabetes and perinatal outcome. Seminars in Neonatology 5: 221-229. Daniels, A.R., Patel, M., Biersma, R., Otten, J. & Levitt, N.S. et al. 2000. A structured record to implement the national guidelines for diabetes and hypertension care. South African Medical Journal 90: 53-56. Kaplan, F.J. & Levitt, N.S. 2000. Insulinoma presenting as temporal lobe epilepsy. South African Medical Journal 90: 777- 779. Kaplan, F.J.L., Levitt, N.S. & Soule, S.G. 2000. Primary hypoadrenalism assessed by the 1µg ACTH test in hospitalised patients with active pulmonary tuberculosis. Quarterly Journal of Medicine 93: 603-609. Levitt, N.S., Unwin, N. & Bradshaw, D. et al. 2000. Application of the new ADA criteria for the diagnosis of diabetes to population studies in sub-Saharan Africa. Diabetic Medicine 17: 381- 385. Lourens, W., Bonnici, F., Hertz, M., Arora, V. & Roach, P. 2000. Improved glycaemic control with Humalog Mix25 compared with human insulin 30/70 in patients with type 2 diabetes. Journal of Endocrinology, Metabolism & Diabetes of South Africa 5(2): 87-92. Soule, S., Davidson, J. & Rayner, B. 2000. The evaluation of primary hyperaldosteronism. South African Medical Journal 90: 387-394. Soule, S., Van Zyl Smit, C., Parolis, G., Attenborough, S., Peter, D., Kinvig, S., Kinvig, T. & Coetzer, E. 2000. The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism. Clinical Endocrinology 53: 221-227. Steyn, K., De Wet, T., Richter, L., Cameron, N., Levitt, N.S. & Morrell, C. 2000. Cardiovascular disease risk factors in 5-year-old urban South African children- the birth-to-ten study. South African Medical Journal 90: 719-726.
ABSTRACTS
Aginsky, J., Visser, M. & Levitt, N.S. 2000. The inter- and intraindividual variation in glycaemic and insulin responses to glucose and white bread in healthy male subjects. Biennial Nutrition Congress of South Africa, Durban. Aginsky, J., Visser, M.E. & Levitt, N.S. 2000. The Inter- and Intraindividual Variation in Glycaemic Response to Glucose and White Bread in Healthy Male Subjects. Society for Endocrinology, Metabolism & Diabetes in South Africa, Durban. Lambert, E.V., Levitt, N.S. & Woods, D. 2000. Heart-Rate Variability and Urinary Catecholamines in a Low Birthweight Cohort of Young South Africans. Society for Endocrinology, Metabolism & Diabetes in South Africa, Durban. Levitt, N.S., Lambert, E.V., Woods, D.L. & Seckl, J.R. 2000. Altered HPA Responsiveness in Young South African Adults with Low Birth Weight. Society for Endocrinology, Metabolism & Diabetes in South Africa, Durban.
75
Matwa, P.N., Dick, J. & Levitt, N.S. 2000. Knowledge, Attitudes and Practices of Xhosa Speaking Diabetic Patients regarding the Optimum Care of their Feet. Society for Endocrinology, Metabolism & Diabetes in South Africa, Durban. McMahon, C.L., Welman, C., Lambert, V.L., Levitt, N.S. & Woods, D. 2000. Anthropometric and CT- derived measures of visceral obesity in young South African adults. Biennial Nutrition Congress of South Africa, Durban. Levitt, N.S., Steyn, K., Daniels, A.D., Lombard, C. & Zwarenstein, M.F. 2000. Does Primary Care for Diabetes in South Africa meet National Guideline Standards? IDEG Satellite meeting to the IDF Congress, Acapulco. Levitt, N.S., Steyn, K., Hoffman, M., Lombard, C., Lambert, E.V., Daniels, A. & Fourie, J. 2000. Insulin resistance is associated with a clustering of metabolic disorders in a South African community. International Diabetes Federation Congress, Mexico City. Nthangeni, N.G., Alberts, M., Steyn, N.P., Steyn, K. & Levitt, N.S. 2001. Comparison of Macro- and Micronutrient Intakes in Africa Type 2 Diabetic Patients in the Northern Province. Society for Endocrinology, Metabolism & Diabetes in South Africa, Durban. Soule, S.G., Coetzer, E., Van Zyl Smit, C., Parolis, G., Attenborough, S., Peters, D., Kinvig, T. & Kinvig, S. 2000. The 1µg ACTH stimulation test for the evaluation of ACTH deficiency in patients with hypopituitarism. 36th Society for Endocrinology, Metabolism & Diabetes in South Africa, Durban.
UNIVERSITY PUBLICATIONS AND WORKS OF A POPULAR NATURE
Soule, S.G. 2000. Prolactin inhibitors. In Gibbon, C.J. (ed.) South African Medicines Formulary 5th Edition: 199-201. Cape Town: SAMA Health and Medical Publishing Group. Soule, S. 2000. Male menopause – fact or fiction? OsteoNews Issue 15, April.
CONSULTANCIES AND OTHER ACTIVITIES BASED ON EXPERTISE IN RESEARCH
Professor F Bonnici -Consultative Section on Education and Section on Childhood and Adolescent Diabetes of the International Diabetes Federation; Contributor, ISPAD Consensus Guidelines for the Management of type 1 diabetes; Board of Trustees, The Diabetes Education Foundation; Expert Diabetes Education Study Group of the European Association for the Study of Diabetes; International Editorial Advisory Board, Practical Diabetes International; Scientific Programme Committee, 17th IDF Congress Mexico 2000; WHO Expert Advisory Panel (Diabetes); Diabetes Atlas 2000 Editorial Committee and French translator. Associate Professor N S Levitt - Chairperson Society for Endocrinology Metabolism and Diabetes of Southern Africa Co-Ordinator of Subgroup for Development of National Guidelines for the Management of Type 1 and Type 2 Diabetes at hospital level in South Africa (Department of Health). Member of subgroups for Development of National Guidelines for the Management of Obesity at Primary Care Level in South Africa (Department of Health). Consultant to Chronic Diseases of Lifestyle Group, Medical Research Council. Dr B H Ascott-Evans - National Advisory Board on Bisphosphonates. Consultancy service (academic expert/opinion leader) to 3 international pharmaceutical companies involved in Osteoporosis, and 2 in Diabetes - related to track record in international clinical research and academic standing. Dr S Soule - Member of Organising Committee Osteoporosis Congress – Densitometry Course, Cape Town Oct 2000. Member of Executive Committee of National Osteoporosis Foundation. Member of SEMDSA Executive Committee.
76
GASTROINTESTINAL CLINIC
HEAD OF CLINIC - Professor Japie Louw
CONTACT DETAILS Postal Address: GI Clinic, E23 New Main Building Groote Schuur Hospital Observatory 7925 Cape Town Telephone: SA (21) 404-3040/1 Fax: SA (21) 447-0582 Email: [email protected]
DEPARTMENTAL PROFILE
The Gastrointestinal Clinic is a multi-disciplinary clinical unit consisting of Medical and Surgical components. This report primarily reflects the Medical component. The Clinic carries a large clinical load and offers a number of specialised services, with clinical and applied research interests in: Hepatobiliary disease - surgical; Colorectal disease - surgical; Oesophageal disease - medical/surgical; Inflammatory bowel disease - medical/surgical; and H.pylori related disease - medical. The Clinic is involved in collaborative research projects with Professor IM Modlin (Yale), Professor L Tang (Yale), Professor S Schreiber (Christian Albrechts University, Kiel, Germany), Dr JC Atherton (Nottingham, UK), Dr M Achtman (Max-Planck Institüt, Berlin, Germany), and the GI Unit, University of Stellenbosch and Tygerberg Hospital.
UNIT STATISTICS
PERMANENT AND LONG TERM CONTRACT STAFF STUDENTS Professors 1 Emeritus Professors 1 Doctoral 2 Senior Lecturers 1 Masters 2 Research Staff 2 TOTAL 4 Administrative and 1 Clerical Staff TOTAL 6
RESEARCH FIELDS
Professor Japie Louw Head of GI Clinic; Helicobacter pylori: role in gastric carcinogenesis: this includes clinical (case control studies), molecular assessment of strain diversity, pathogenic role of various H.pylori components on cell proliferation (with M Kidd), the relationship between gastroesophageal reflux and asthma (with M. Letier and Respiratory Clinic); Gastroesophageal reflux disease: assessment of predictors of surgical outcome, audit of surgical outcome (with Surgery); Upper gastrointestinal bleeding: development of outcome predictors (with S Kalula); Achalasia: evaluation of treatment modalitis (with Surgery); the pathobiology of Barrett’s oesophagus (with G Watermeyer); drug trials - various Dr Trevor Winter Senior Specialist; Inflammatory bowel disease: ongoing research includes nutritional aspects of IBD (with N. Kaganson), the role of anti-oxidant vitamins in IBD, genetic studies in IBD (collaborative work with Oxford and Christian Albrechts University, Kiel, Germany), drug trials with novel agents (budesonide, ridogrel)
77
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Winter, T.A., Lemmer, E.R., O’Keefe, S.J.D. & Ogden, J.M. 2000. The effect of severe undernutrition, and subsequent refeeding on digestive function in human patients. European Journal of Gastroenterology & Hepatology 12: 191-196. Van Zyl, J.H., Grundling, H. de K., Van Rensburg, C.J., Retief, F.J., O’Keefe, S.J.D., Theron, I., Fischer R. & Bethke, T. 2000. Efficacy and tolerability of 20 mg pantoprazole versus 300 mg ranitidine in patients with mild reflux-oesophagitis: a randomized, double-blind, parallel, and multicentre study. European Journal of Gastroenterology & Hepatology 12: 197-202. Louw, J.A. & Marks, I.N. 2000. The treatment of peptic ulcer disease. Current Opinion in Gastroenterology 16: 489-494. Kidd, M., Moss, S.F., Tang, L.H., Zhang, T., Chin, K., Holt, P. & Modlin, I.M. 2000. Gastrin mediated alterations in gastric epithelial apoptosis and proliferation in a rodent model of gastric neoplasia. Digestion 62: 143-151. Modlin, I.M., Kidd, M. & Fahardi, J. 2000. Bayliss and Starling and the nascence of endocrinology. Regulatory Peptides 25: 109-123. Kidd, M., Tang, L.H., Schmid, S., Lauffer, J., Louw, J.A. & Modlin, I.M. 2000. Helicobacter pylori lipopolysaccharide alters ECL cell DNA synthesis via a CD14 Receptor and polyamine pathway in mastomys. Digestion 62(4): 217-224.
CHAPTERS IN BOOKS
Modlin, I.M., Fahardi, J. & Kidd, M. 2000. From the pump to the Helix. In Hunt, R.H. & Tytgat, G.N.J. (eds) Helicobacter pylori – Basic mechanisms to clinical cure: 347-372. London: Kluwer Academic Publishers.
UNIVERSITY PUBLICATIONS AND WORKS OF A POPULAR NATURE
Winter, T.A. 2000. Alimentary Tract and Metabolism. In Gibbon, C.J. (ed.) The South African Medicines Formulary, 5th Edition: 32-88. Cape Town: South African Medical Association Health and Medical Publishing Group.
CONFERENCE ABSTRACTS
Lantermann, A., Winter, T.A., Kim, W.H., Nagy, M., Koepke, B., Hampe, J., Folsch, U.R., Flad, H.D. & Schreiber, S. 2000. Investigation of HLA-DPA1 associations with IBD in European, South African and South Korean populations. Gastroenterology 2000. American Gastroenterology Association Annual Conference, San Diego, California. Thomsen, O.O., Cortot, A., Jewel, D., Wright, J., Winter, T.A., Veloso, F.T., Vatn, M., Persson, T. & Pettersson, E. 2000. An evaluation of the effect of budesonide and mesalamine on the clinical condition of patients with active Crohn’s disease. Gastroenterology 2000. American Gastroenterology Association Annual Conference, San Diego, California. Thomsen, O.O., Cortot, A., Jewel, D., Wright, J., Winter, T.A., Veloso, F.T., Vatn, M., Persson, T. & Pettersson, E. 2000. A comparison of the effect of budesonide and mesalamine on quality-of-life in patients with active Crohn’s Disease. Gastroenterology 2000. American Gastroenterology Association Annual Conference, San Diego, California. Kaganson, N., Winter, T.A., Callanan, M. & Paterson, H. 2000. The effect of supplemental Vitamins A and E on relapse rates in Crohn’s disease. South African Medical Journal 90(6):637. South African Gastroenterology Society Annual Conference, Windhoek, Namibia. Kidd, M., Peek, R.M., Lastovica, A.J., Kummer, A.F. & Louw, J.A. 2000. Relationship between Helicobacter pylori iceA genotypes, vacA alleles and clinically significant disease in South Africa. South African Medical Journal 90(6):637. South African Gastroenterology Society Annual Conference, Windhoek, Namibia. Kidd, M., Lastovica, A.J., Perez-Perez, G., Tang, L.H., Modlin, I.M. & Louw, J.A. 2000. The biological relevance of Helicobacter pylori virulence fingerprints. South African Medical Journal 90(6):643. South African Gastroenterology Society Annual Conference, Windhoek, Namibia. Kummer, A.F., Kidd, M., Kotze, U., Taylor, K., Lostovica, A. & Louw, J.A. 2000. Relation between gastric adenocarcinoma (GCA) and H.pylori (HP): a case-control study. South African Medical Journal 90(6):637.
78
Douie, W.J.P., Bornman, P.C., van Wyk, M., Kidd, M., Johnson, C.D. & Fitzsimmons, D. 2000. Which factors influence quality of life (QoL) in patients with chronic pancreatitis after surgery for intractable pain? SA Journal of Surgery 38:23. Association of Surgeons of South Africa Annual Conference, Port Elizabeth. Douie, W.J.P., Bornman, P.C., van Wyk, M., Kidd, M., Beckingham, I. & Terblanche, J. 2000. Is surgery a viable therapeutic option in the management of pain in chronic pancreatitis? SA Journal of Surgery 38:18. Association of Surgeons of South Africa Annual Conference, Port Elizabeth. Mall, A., Suleman, N., Kidd, M., Taylor, K., Tyler, M., Lotz, Z., Hickman, R. & Kahn, D. 2000. The incidence of Helicobacter heilmannii in the normal pig stomach? Surgical Research Society Annual Conference, Cape Town. Mall, A., Suleman, N., Taylor, K., Tyler, M., Lotz, Z., Kidd, M., Hickman, R. & Kahn, D. 2000. Is there an association between H. heilmannii infection, mucus degradation and ulceration of the pars oesophagea of the abattoir pig stomach? Surgical Research Society Annual Conference, Cape Town. Mall, A., Blows, D., Taylor, K., Kidd, M., Tyler, M., Lotz, Z., Hickman, R. & Kahn, D. 2000. Is there an association between H.heilmannii infection, mucus degradation and ulceration of the pars oesophagea in the bile duct ligated pig? A pilot study. Surgical Research Society Annual Conference, Cape Town.
THESES AND DISSERTATIONS PASSED FOR HIGHER DEGREES
Kaganson, N. 2000. The antioxidant vitamin status of Inflammatory Bowel Disease patients: An intervention study : 1-191. M.Sc.(Med) dissertation, University of Cape Town. Kidd, M. 2000. Relationship of Helicobacter pylori virulence to gastric patholobiology in the Western Cape : 1-192. Ph.D.(Med) thesis, University of Cape Town.
UNIVERSITY PUBLICATIONS AND WORKS OF A POPULAR NATURE
Winter, T.A. 2000. Medical management of inflammatory bowel disease: past, present and future. Specialist Medicine XXII:376-388 (invited reprint). Louw, J.A. 2000. What to do about H.pylori in Africa. www.GastroHep.com.
79
GERIATRIC MEDICINE
ACTING HEAD - Dr SZ Kalula
CONTACT DETAILS Postal Address: Geriatric Medicine J47 Old Main Building Groote Schuur Hospital Observatory 7925 Cape Town Telephone: SA (21) 406-6211 Fax SA (21) 448-6815 Email: [email protected]
DEPARTMENTAL PROFILE
Geriatric Medicine is still in its developmental phase in South Africa. This year the Unit has moved to further strengthen the development of locally appropriate, resource independent, problem focused and responsive services, paralleled with clinical training which emphasises interdisciplinary collaboration, which is community and outreach focused, and promotes bi-directional care.
The problem focused initiatives such as the Memory and Stroke Services, Syncope and TIA Clinics, have provided the much needed support to hospitals and the community. The participation in the Rehabilitation Services based at Conradie Hospital, has been of mutual benefit to medical professionals and students and has provided better patient care.
The recognition of the inescapable interdependence of Ageing disciplines led to the formulation of closer links between these disciplines. This has culminated in the establishment of the Institute of Ageing in Africa comprising of Geriatric Medicine with the strongly related disciplines of Gerontology (HSRC UCT Centre) and Psycho-Geriatrics. This has combined the strengths of each discipline and eliminated an unsustainable duplication of skills and resources, forming a strong cross-disciplinary partnership. This can only strengthen our research capacity and promote national and international links in education and research, further promoting better patient care. This will serve as a model for future Geriatric Service development in Sub-Saharan Africa, and respond to, and meet, the challenges of an Ageing Africa in the new millennium.
Research partnerships have been created with the International 10/66 Dementia Group and plans are underway to form links with the Oxford Department of Gerantology in the year 2001. The Unit is collaborating with the WHO in the establishment of an African minimum data set.
UNIT STATISTICS
PERMANENT AND LONG HONORARY STAFF TERM CONTRACT STAFF Senior Lecturers 1 Professors 1 Lecturers 2 Senior Lecturers 1 TOTAL 3 Senior Registrars 1 Medical Officers (part- 1 STUDENTS time) Masters 1 Secretarial and Admin 1 M.Phil. 1 Staff TOTAL 2 TOTAL 5
RESEARCH FIELDS
Professor AO Wilson Characteristics and Prevalence of Dementia in Rural and Urban Xhosa communities; Syncope, carotid sinus hypersensitivity, arrythmias, and pacemakers; stroke - interventions in morbidity and disability
80
Dr S Z Kalula Clinical predictors in the outcome of upper GIT haemorrhage; Epidemiology of dementia in developing countries Dr L De Villiers Stroke Rehabilitation (young stroke)
DISTINGUISHED VISITORS
Dr Martin Prince London School of Hygiene and Tropical Medicine, UK. Prof John Copeland University of Liverpool, Liverpool, UK.
RESEARCH OUTPUTS
THESES AND DISSERTATIONS PASSED FOR HIGHER DEGREES
Kalula, S.Z. 2000. The development and testing of an instrument for assessment of dependency needs of older persons in South Africa: 1-135. M.Med. dissertation, University of Cape Town.
81
HEART RESEARCH UNIT AND HATTER INSTITUTE FOR CARDIOLOGY RESEARCH
HEAD OF DEPARTMENT Dr Michael N Sack (Director: Hatter Institute for Cardiology Research) Professor Lionel H Opie (Director: Heart Research Unit)
CONTACT DETAILS Postal Address: Cape Heart Centre University of Cape Town Medical School Observatory, 7925 Cape Town Telephone: SA (21) 406-6350 Fax: SA (21) 447-8789 Email: opie@capeheart, sack@capeheart
DEPARTMENTAL PROFILE
During the past twelve months we have integrated the research within the Heart Research Unit and Hatter Institutes. This combined research entity is now probably the largest heart research group in the country, and incorporates molecular, cellular and physiological studies in heart disease. To enhance our productivity, we have consolidated the research programmes, and modestly expanded the number of research personnel. One additional master's student, one additional PhD student and one clinician postdoctoral fellow have joined the laboratory in the last twelve months.
A number of collaborative research initiatives have been established both in Cape Town and internationally. These include:
Links between the Hatter Institutes, University College London and Cape Town. For the fourth consecutive year, formal collaboration between these institutes will be celebrated by the presentation Cardiology at the Limits – IV in Cape Town during October 2000. This symposium brings together experts in Cardiology from the USA, Europe and South Africa. The link with University College London has also resulted in obtaining combined funding for research from the Wellcome Trust in the UK.
Collaboration with the University of the Western Cape. Professor Daneel Dietrich of the Department of Physiological Sciences, University of the Western Cape, has entered into a long-term research collaboration with us. She is now doing important preliminary research to enable her to apply for a distinguished Wellcome Trust Award in the United Kingdom. The collaboration which will be developed between the University of Cape Town and the University of the Western Cape during the tenure of such a fellowship is intended to be of an ongoing nature, so that the training of historically disadvantaged science students in South Africa will be facilitated by this plan.
Collaboration with the Cardiac Clinic – GSH. Two clinicians have joined the laboratory and work concurrently in the cardiac clinic. These individuals (Dr David Marshall and Dr Chris McLeod) are supported, in part, by the cardiac clinic research fund.
Additional Research Collaborative Initiatives: Washington University Medical School, St. Louis, MO, USA. Collaborative study with Dr Daniel P. Kelly - Center for Cardiovascular Research. University of California, San Diego, San Diego, CA, USA. Collaborative Study with Dr Ken Chien.
STATISTICS
PERMANENT AND LONG TERM POSTDOCTORAL STUDENTS CONTRACT STAFF RESEARCH FELLOWS M.Sc. 2 Professor 1 Postdoc Fellows 5 Ph.D. 4 Senior lecturer 1 TOTAL 5 TOTAL 6 Honorary Professor 1 Visiting Professor 1 Clinical Staff 6 82 TOTAL 10
RESEARCH FIELDS
Dr Michael Sack, Dr Faadiel Essop, Ms Kholiswa Ngumbela, Ms Nayna Manga, Mr Siyanda Makaula, Ms Joy McCarthy Molecular regulation of cardiac energy metabolism and its contribution to heart disease Dr Michael Sack, Professor Lionel Opie, Professor Derek Yellon, Professor Daneel Dietrich, Dr Jan Minners, Dr Chris McLeod, Dr Sandrine Lecour, Dr Rob Smith, Ms Anne Jonassen, Mr James Meiring, Ms Lydia Lacerda Delineation of cellular and molecular mechanisms promoting cardiac protection
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Aitchison, K.A., Baxter, G.F., Awan, M.M., Smith, R.M., Yellon, D.M. & Opie, L.H. 2000. Opposing effects on infarction of delta and kappa opioid receptor activation in the isolated rat heart: implications for ischemic preconditioning. Basic Research in Cardiology 95: 1-10. Awan, M.M., Makaula, S., Forresti, S., Sack, M.N. & Opie, L.H. 2000. Mechanisms whereby glucose deprivation triggers metabolic preconditioning in the isolated rat heart. Molecular and Cellular Biochemistry 211: 111-121. Bell, P., Sack, M.N., Patel, A., Opie, L.H. & Yellon, D.M. 2000. Delta opioid receptor stimulation mimics ischemic preconditioning in human heart muscle. Journal for the American College of Cardiology 36(7): 2296-2302. Jonassen, A.K., Brar, B.K., Mjos, O.D., Sack, M.N., Latchman, D.S. & Yellon, D.M. 2000. Insulin administered at reoxygenation exerts a cardioprotective effect in myocytes by a possible anti- apoptotic mechanism. Journal of Molecular and Cellular Cardiology 32: 757-764. Marshall, D. & Sack, M.N. 2000. Apoptosis: a pivotal event or an epiphenomenon in the pathophysiology of heart failure? Heart 84: 355-356. Minners, J., van den Bos, E.J., Yellon, D.M., Schwalb, H., Opie, L.H. & Sack, M.N. 2000. Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in isolated rat heart: support for a mitochondrial role in cardioprotection. Cardiovascular Research 47: 68-73. Opie, L.H. 2000. Adverse cardiovascular drug interactions. Current Problems in Cardiology 25: 621- 676. Opie, L.H. 2000. Diuretic downsides – but in low doses they still seem among the best authenticated antihypertensives. Cardiovascular Drugs and Therapy 14: 407-409. Opie, L.H. 2000. View point article: First line drugs in chronic stable effort angina – the case for newer longer-acting calcium channel blockers. Journal of the American College of Cardiology 36: 1967-1971. Opie, L.H., Yusuf, Y. & Kubler, W. 2000. Current status of safety and efficacy of calcium channel blockers in cardiovascular diseases: a critical analysis based on 100 studies. Progress in Cardiovascular Disease 43: 171-196. Rayner, B.L., Opie, L.H. & Davison, J.S. 2000. The aldosterone/renin ratio as a screening test for primary aldosteronism. South African Medical Journal 90: 394-400. Sack, M.N., Harrington, L.S., Jonassen, A.K., Mjos, O.D. & Yellon, D.M. 2000. Coordinate regulation of metabolic enzyme encoding genes during cardiac development and following carvedilol therapy. Cardiovasular Drugs and Therapy 14: 31-39. Sack, M.N., Smith, R.M. & Opie, L.H. 2000. Tumour necrosis factor in myocardial hypertrophy and ischaemia – an anti-apoptotic perspective. Cardiovascular Research 45: 688-695.
BOOKS
Opie, L.H. 2000. Drugs for the Heart, 5th Edition: 1-426. Philadelphia: W B Saunders Company.
CHAPTERS IN BOOKS
Kantor, P.F., Lopaschuk, G.D. & Opie, L.H. 2000. Myocardial Energy Metabolism. In Sperelakis, N., Kurachi, Y., Terzic, A. & Cohen, M.V. (eds) Heart Physiology and Pathophysiology, 4th Edition: 543-569. San Diego: Academic Press.
83
CONFERENCE ABSTRACTS
Makaula, S., Awan, M., Lochner, Sack, M. & Opie, L. 2000. H89, an inhibitor of PKA activity, administerd as a pretreatment or with subthreshold preconditioning promotes recovery of contractile function following ischemia/ reperfusion - a putative novel cardioprotective agent. American Heart Association Meeting, New Orleans. Circulation, 102 (Suppl II); II-269. Makaula, S., Awan, M., Lochner, Sack, M. & Opie, L. 2000. H89, an inhibitor of PKA activity, administerd as a pretreatment or with subthreshold preconditioning promotes recovery of contractile function following ischemia/ reperfusion - a putative novel cardioprotective agent. South African Heart Association Meeting, Stellenbosch. Meiring, J. 2000. TNFα promotes tolerance against ischemic damage in myocytes via NFκB activation - a putative autocrine/paracrine mediator of ischemic preconditioning. South African Heart Association Meeting, Stellenbosch. Minners, J., Meiring, J.J., van den Bos, E.J., Opie, L.H. & Sack, M.N. 2000. Inner mitochondrial membrane modulation in preconditioned myotubes: a putative role for mitochondrial homeostasis in enhanced tolerance to ischemia. American Heart Association Meeting, New Orleans. Circulation, 102 (Suppl II); II-287. Ngumbela, K. 2000. Cardiac medium-chain acyl CoA dehydrogenase is downregulated at pre- and post- translational levels following acute hypoxia in mice. South African Heart Association Meeting, Stellenbosch. Ngumbela, K., Essop, F.M. & McLeod, C. 2000. Cardiac medium-chain acyl CoA dehydrogenase is downregulated at pre- and post-translational levels following acute hypoxia in mice. American Heart Association Meeting, New Orleans. Circulation, 102 (Suppl II); II-344. Sack, M. 2000. TNFα and myocardial protection. South African Heart Association Meeting, Stellenbosch. van den Bos, E.J., Minners, J., Opie, L.H. & Sack, M.N. 2000. Trimetazidine abolishes ischemic and drug-induced preconditioning: does mitochondrial protection antagonize preconditioning-like cardioprotection? American Heart Association Meeting, New Orleans. Circulation, 102 (Suppl II); II-269.
THESIS AND DISSERTATIONS
Makaula, S. 2000. Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart: 1-122. M.Sc. dissertation, University of Cape Town. Sack, M.N. 2000. Changing concepts of metabolic regulation in the heart: 1-190. Ph.D. thesis, University of Cape Town.
84
HYPERTENSION CLINIC
HEAD OF DEPARTMENT - Associate Professor Brian Rayner
CONTACT DETAILS Postal Address: E13, New Groote Schuur Hospital Observatory 7925 Cape Town Telephone: SA (21) 404-3495 Fax: SA (21) 448-2349 E mail: [email protected]
DEPARTMENTAL PROFILE
Completed research: Two projects were completed this year. The first related to the prevalence of PA in the Hypertension Clinic at Groote Schuur Hospital, and the second related to the normal ranges of aldosterone and renin in the normotensive population, and the prevalence of PA among hypertensives attending primary care clinics in the major ethnic grouping in the Western Cape. The former project was published in the South African Medical Journal, and the latter has been submitted for publication. The projects were done in conjunction with Prof. James Davidson from Chemical Pathology, and Prof J. Myers from Community Health.
Research in progress: i) Prognostic significance of aortic unfolding in hypertensive patients. This is a pilot study to determine if unfolding of the aorta has prognostic significance in patients with hypertension. Recruitment of patients has been completed and analysis of the data is in progress with the view to publication. ii) Primary Aldosteronism (PA) The major focus of the research activities of the Hypertension Clinic are in the field of primary aldosteronism.
Projects in progress Protocol for screening and investigation of primary aldosteronism. This project will investigate the sensitivity and specificity of the aldosterone/renin ratio as compared to the saline suppression test (the gold standard for diagnosing PA) in hypertensive patients with the view to developing cost effective strategies for the investigation of patients with hypertension in the South African context. Funding has been received from the SA Hypertension Society for this project. The project is being done in conjunction with Prof. James Davidson from Chemical Pathology, and Drs Soule and Raubenheimer from the Endocrine Dept.
Frequency of Epithelial Na+ channel polymorphisms in the South African population This project is being done in conjunction with Prof. James Davidson from the Dept of Chemical Pathology. It stems from our observation that normotensive African patients have highly suppressed renin and aldosterone. Funding has been received from the SA Hypertension Society for this project.
Fibrillin and Hypertension In conjunction with Prof. Eric Harley of the Dept. of Chemical Pathology research is being conducted into abnormalities in the fibrillin gene as a possible cause for essential hypertension. Funding has been received from the MRC for this work.
Efficacy and safety of Indapamide SR 1.5 mg per os in 400 hypertensive NIDDM patients with microalbuminuria and essential hypertension. This is a multi-centre international trial comparing indapamide versus enalapril in reducing microalbuminuria in hypertensive NIDDM patients. The Hypertension Clinic is one of the participating centres, and the study is being co-ordinated by Dr Yvonne Trinder.
Clinical protocol for double-blind, randomised, placebo and active controlled comparison study of the antihypertensive effect and safety of eplerenone versus placebo and versus losartan in black and white hypertensive patients. Phase III clinical trial.
85
This is a multicentre international trial investigating the safety and efficacy of the new aldosterone antagonist, eplerenone, in black and white hypertensives. 18 patients were entered into the study at our site, and it was completed in November.
A double blind randomized dose- response study of losartan in children with hypertension. This study will be started as soon as approval is obtained from the MCC.
The efficacy of the AT1 receptor antagonist, losartan, in the treatment of patients with resistant low renin hypertension.
STATISTICS
PERMANENT AND LONG TERM CONTRACT STAFF Full-time professional staff 3 Part-time professional staff 3 Research Staff 2 TOTAL 8
RESEARCH FIELDS
Associate Professor Brian Rayner Primary aldosteronism, AT1 receptor antagonists, contract research Dr Y Trinder Contract Research
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Rayner, B.L., Opie, L.H. & Davidson, J.S. 2000. Aldosterone/renin ratio as a screening test for primary aldosteronism. South African Medical Journal 90: 387-394. Soule, S.J., Davidson, J.S. & Rayner, B.L. 2000. The Evaluation of Primary Aldosteronism. South African Medical Journal 90: 387-394.
CONGRESS ABSTRACTS
Rayner, B.L., Opie, L.H., Trinder, Y.A. & Davidson, J.S. 2000. Primary aldosteronism; a community based survey in 3 ethnic communities in Cape Town, South Africa. American Journal of Hypertension 13: 175A.
INTERNATIONAL CONGRESSES
Rayner, B.L., Myers, J., Opie, L.H., Trinder, Y.A. & Davidson, J.S. 2000. Primary aldosteronism: a community based survey in 3 ethnic communities in Cape Town, South Africa. Congress on “Primary aldosteronism: into a new millennium”, 15th Scientific meeting of the American Society of Hypertension, New York. Rayner, B.L., Trinder, Y.A. & Davidson, J.S. 2000. Efficacy of losartan in patients with low renin resistant hypertension. AII College, Limerick, Ireland.
86
LIPID CLINIC AND LABORATORY
HEAD OF DEPT - Associate Professor AD Marais
CONTACT DETAILS Postal Address: Lipid Laboratory Cape Heart Centre University of Cape Town Anzio Road Observatory, 7925 Cape Town Telephone: SA (21) 406-6166 Fax: SA (21) 406-6396 Email: [email protected]
DEPARTMENTAL PROFILE
The lipid clinic and laboratory of the University of Cape Town and Groote Schuur Hospital is in a strong position for providing expert opinion with respect to clinical and laboratory diagnosis of dyslipoproteinaemia and from this base, to perform research into disorders of lipid and lipoprotein metabolism of local and international interest. The clinic and laboratory, though small, are viewed as a local and international centre of expertise. The clinic and laboratory have been able to perform pharmaceutical studies for newer drugs to treat severe hypercholesterolaemia. The funds raised through these studies have allowed a diagnostic laboratory to develop and also permitted international collaborations into the mechanism of action of drugs, descriptions of dyslipoproteinaemia, and the metabolic derangements in dyslipoproteinaemia. One of the achievements from this group is the finding that statin drugs are effective in homozygous familial hypercholesterolaemia. This was exsplained by a reduced production of lipoproteins as their increased removal from the plasma is not possible due to the defect in this disorder. There is scope for expanding clinical and laboratory investigation provided that clinical service and administrative burdens do not preclude such development.
STATISTICS
PERMANENT AND LONG TERM STAFF Associate Professors 3 Senior Lecturers 1 Registrars 2 Medical Officers 3 Nursing 3 Dietitians 2 Laboratory Staff 5 Administrative Staff 3 TOTAL 22
RESEARCH FIELDS
JC Firth, ME Bateman, SG Soule, J Davidson, Y Dhansay, D Blom, AD Marais Dyslipoproteinaemias in patients referred for management JC Firth, KH Wolmarans, RM Jooste, CA Fuller, AD Marais ZD4522 in heterozygous and homozygous familial hypercholesterolaemia JC Firth, KH Wolmarans, RM Jooste, CA Fuller, AD Marais fluvastatin 80mg slow release formulation in hypercholesterolaemia JC Firth, KH Wolmarans, RM Jooste, CA Fuller, AD Marais atorvastatin in adolescents with familial hypercholesterolaemia JC Firth, KH Wolmarans, RM Jooste, CA Fuller, M Levey, D Blackhurst, AD Marais atorvastatin, avasimibe and their combination in homozygous familial hypercholesterolaemia; Prevalence of apolipoprotein E R145C in type III hyperlipidaemia and black population P Byrnes, S Jones, AD Marais Anti-oxidant effect of alcoholic beverages on lipid peroxidation in edible oils 87
D Blackhurst, AD Marais Breath tests for chylomicron remnant-like lipoproteins
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Berger, G.M. & Marais, A.D. 2000. Diagnosis, Management and Prevention of the Common Dyslipidaemias in South Africa - Clinical Guideline, 2000. South African Medical Journal 90: 164-178. Clee, S.M., Bissada, N., Miao, F., Miao, L., Marais, A.D., Henderson, H.E., Steures, P., McManus, B., LeBoeuf, R.C., Kastelein, J.J.P. & Hayden, M.R. 2000. Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis. Journal of Lipid Research 41: 521-531. Marais, A.D. 2000. Therapeutic modulation of LDL particle size. Current Opinion in Lipidology 11(6): 597-602. Raal, F.J., Pappu, A.S., Illingworth, R.I., Pilcher, G.J., Marais, A.D., Firth, J.C., Kotze, M.J., Heinonen, T.M. & Black, D.M. 2000. Inhibition of cholesterol synthesis by atorvastatin in homozygous familial hypercholesterolaemia. Atherosclerosis 150: 421-428.
CONFERENCE ABSTRACTS
Blackhurst, D.M. & Marais, A.D. 2000. The antioxidant effect of wine on lipid oxidation in edible oils. Research Day, Department of Medicine, University of Cape Town. Blackhurst, D.M. & Marais, A.D. 2000. Lipid oxidation in edible oils: an evaluation using three spectrophotometric methods. Lipid Laboratory, Cape Heart Centre, Health Science Faculty, University of Cape Town, Observatory, 7925 South Africa. 6th LASSA Symposium, Durban South Africa. Clee, S., Henderson, H.E., Ratanjee, B.D., Hayden, M.R. & Marais, A.D. 2000. Use of gradient gel electrophoresis (GGE) to investigate lipoprotein particle size in apo-E knock-out mice expressing variable levels of lipoprotein lipase. Medical Genetics, Univ British Columbia, Chemical Pathology and Internal Medicine, Univ of Cape Town. 6th LASSA Symposium, Durban, South Africa. Firth, J.C., Marais, A.D., Byrnes, P., Fuller, C.A. & Bonnici, F. 2000. Fluvastatin in heterozygous familial hypercholesterolaemia. 35th Annual General Meeting of Association of European Paediatric Cardiology. Strasbourg, France.. Fuller, C.A., Firth, J.C., Wolmarans, K.H., Byrnes, P., Jooste, R.M. & Marais, A.D. 2000. Efficacy of Dietary Modification in Children with Familial Hypercholesterolaemia (FH). Lipid Laboratory, Internal Medicine, Health Science Faculty, University of Cape Town. 6th LASSA Symposium, Durban South Africa. Henderson, H.E., Clee, S., Ratanjee, B.D., Hayden, M.R. & Marais, A.D. 2000. The use of gradient gel electrophoresis (GGE) to investigate lipoprotein particle size variation in apoE knockout mice expressing varying levels of lipoprotein lipase (LPL). Division of Pathology Research Day. Insull, W., Marais, A.D., Aronson, R. & Manfreda, S. 2000. Fluvastatin extended-release formulation is effective in treating primary hypercholesterolaemia. XII ISA, Stockholm, Sweden. Marais, A.D. 2000. Electrophoretic descriptions of lipoproteins for the diagnosis of dyslipoproteinaemias. Lipid Laboratory, Internal Medicine, Health Science Faculty, University of Cape Town. 6th LASSA Symposium, Durban, South Africa. Marais, A.D. 2000. The clinical approach to dyslipidaemia in South Africa. Lipid laboratory, Internal medicine, Health Science Faculty, University of Cape Town. 6th LASSA Symposium, Durban South Africa. Marais, A.D., Byrnes, P. & Purdie, N. 2000. Modified Chugaev reaction for the derivation of cholesterol in lipoprotein fractions: a pilot study. Internal Medicine, University of Cape Town, Chemistry Department, Oklahoma State University, Stillwaters, OK, USA. 6th LASSA Symposium, Durban South Africa. Marais, A.D., Jones, S., Firth, J.D., Byrnes, P., Ross, J.K., Moodie, M. & Gaffney, D. 2000. Familial defective apolipoprotein B is of varied origin in South Africa.Lipid Laboratory, UCT Health Science Faculty and Pathological Biochemistry, University of Glasgow, Scotland. 6th LASSA Symposium, Durban, South Africa. Pillay, T., Commerford, P.J. & Marais, A.D. 2000. A retrospective analysis of risk factors, clinical and angiographic characteristics in young females presenting with acute coronary syndromes. South African Heart Association Congress, Stellenbosch.
88
Rubinstein, A., Marais, A.D., Szostak, W.B., Colquhoun, D., Keber, I., Werba, J.P., Bertolami, M., Stolero, D. & Tal, S. 2000. Efficacy and safety of cerivastatin 0.8mg versus pravastatin 40mg for treatment of dyslipidaemia. XII ISA, Stockholm, Sweden.
UNIVERSITY PUBLICATIONS AND WORKS OF A POPULAR NATURE
Marais, A.D. 2000. Serum lipid-reducing agents. In Gibbon, C.J. (ed.) South African Medicines Formulary 5th Edition: 150-156. Cape Town: South African Medical Association Health & Medical Publishing Group. Marais, A.D. 2000. Dyslipidaemia in Diabetes Mellitus. Specialist Medicine 22: 148-179. Marais, A.D. 2000. Will more aggressive lowering of plasma cholesterol concentrations better prevent coronary heart disease? South African Journal of Continuing Medical Education 18 (1):57,58 (Part I;18 (2): 168,169 (Part II); 18 (3):252,253 (Part III).
89
MRC/UCT LIVER RESEARCH CENTRE
EXECUTIVE DIRECTOR – Professor RE Kirsch CO-DIRECTOR – Professor J. Terblanche
CONTACT DETAILS Postal Address: MRC/UCT Liver Research Centre Departments of Medicine and Surgery University of Cape Town Medical School Observatory, 7925 Cape Town Telephone: SA (21) 406-6200 Fax: SA (21) 447-9670 Email: [email protected]
DEPARTMENTAL PROFILE
The Centre is multidisciplinary and its members consist of physicians, surgeons, biochemists, immunologists and pathologists. Apart from its laboratories in the Departments of Medicine, Surgery, Biochemistry, virology and Anatomical Pathology the Centre runs the only multidisciplinary, comprehensive, liver clinic, including a liver transplantation program, in Africa.
The Centre’s Mission is to serve as a national resource by:
• increasing the understanding of the liver in health and disease • identifying and studying diseases of the liver which occur in Southern Africa • identifying and studying measures capable of preventing liver disease • identifying and studying methods of improving the health of patients with liver disease • disseminating information which will allow health authorities and health workers to prevent liver disease, to promote health by emphasising dangers such as alcohol abuse and to improve the care of patients with already existing liver disease • developing human resources capable of continuing to fulfil our mission and in doing so to give preference where possible to persons disadvantaged as a result of discrimination on the basis of their race or gender.
Major areas of research include: porphyria, viral hepatitis, chronic hepatitis, immune abnormalities in liver disease, immunosuppressive factors in the venom of bitis arietans, the role of hepatic stem cells in experimental cirrhosis, liver transplantation, the pathogenesis of cardiovascular changes in portal hypertension, the role of portal systemic shunting in abnormal energy metabolism of liver disease, laparoscopic cholecystectomy, the treatment of bile duct calculi, the management of portal hypertension, and new methods of liver resection.
The Centre currently collaborates with 5 overseas and 3 South African universities and with 9 Departments within UCT.
STATISTICS
PERMANENT AND LONG HONORARY STAFF STUDENTS TERM CONTRACT STAFF Professors 5 Honorary Staff 3 Ph.D. students 8 Associate Professors 6 TOTAL 3 TOTAL 8 Senior Lecturers 9 Senior Research 10 Officers Technical Support Staff 10 TOTAL 40
90
RESEARCH FIELDS
Kirsch RE Medical education, health services, porphyria, hepatitis, infection and liver disease, cardiovascular manifestations of portal hypertension Terblanche J Management of portal hypertension, new methods of liver resection laparoscopic cholecystectomy, treatment of bile duct calculi Bornman PC Management of portal hypertension, new methods of liver resection laparoscopic cholecystectomy, treatment of bile duct calculi Hall P Alcoholic liver disease, chronic hepatitis, non-alcoholic steatohepatitis Kahn D liver transplantation, liver regeneration Krige JEJ Management of portal hypertension, new methods of liver resection laparoscopic cholecystectomy, treatment of bile duct calculi Miller AJW Liver transplantation Shephard EG Immunology of liver disease Campbell JAH Experimental cirrhosis Hift RJ Porphyria, iron overload Spearman CWN Liver transplantation Matsiliza N Cardiovascular manifestations of portal hypertension Corrigall AV Porphyria Mall A The role of mucus in the pathogenesis of gallstones Meissner PN Porphyria Sturrock E Angiotensin converting enzyme
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Botha, J.F., Tandon, V., Linley, W., Mall, A., Davison, D., McKenzie, I., Kahn, D. & Sandrin, M. 2000. Prolonged survival of baboon renal allografts using idarubicin conjugated anti-CD4 monoclonal antibodies. Transplantation International 13 (Suppl 1): S480-S481. Botha, J.F., Krige, J.E.J. & Bornman, P.C. 2000. Current perspectives in the endoscopic management of non-variceal upper gastrointestinal bleeding. Digestive Endoscopy 12: 3-7. Botha, J.F., Spearman, C.W., Millar, A.J.W., Michell, L., Gordon, P., Lopez, T., Butt, A., Thomas, J., McCulloch, M., James, M., Kirsch, R.E., Terblanche, J. & Kahn, D. 2000. Ten years of liver transplantation at Groote Schuur Hospital. South African Medical Journal 90 (9): 880. Corrigall, A.V., Hift, R.J., Davids, L.M., Hancock, V., Meissner, D., Kirsch, R.E. & Meissner, P.N. 2000. Homozygous variegate porphyria in South Africa: Genotypic analysis in 2 cases. Molecular Genetics & Metabolism 69: 323-330. Kirsch, R., Woodburne, V.E., Shephard, E.G. & Kirsch, R.E. 2000. Neutrophil function is normal in patients with stable uncomplicated cirrhosis. Gastroenterology and Hepatology 15: 1298-1306. Krige, J.E.J., Bornman, P.C., Goldberg, P.A. & Terblanche, J. 2000. Variceal Rebleeding and Recurrence after endoscopic injection sclerotherapy: A Prospective Evaluation in 204 patients. Archives of Surgery 135: 1315-1322. Letier, M.H., Krige, J.E.J., Lemmer, E.R. & Terblanche, J. 2000. Injection sclerotherapy for variceal bleeding in patients with irresectable hepatocellular carcinoma. Hepato-Gastroenterology 47: 1672-1676. 91
Marr, J.D.F., Krige, J.E.J. & Terblanche, J. 2000. Analysis of 153 gunshot wounds of the liver. British Journal of Surgery 87: 1030-1034. Mall, A.S., Lotz, Z., Tyler, M., Mcleod, H., Hickman, R., Dent, D. & Kahn, D. 2000. Increased Fragmentation of MUC5AC mucin in gastric juice of patients with ulceration and carcinoma. South African Journal of Science 96(1): 39-43. Pontin, A.R., Pascoe, M.D., Botha, J.F., Tandon, V. & Kahn, D. 2000. Does rural follow-up of renal allografts give impaired graft survival? Transplant International 13: S92-S94.
CHAPTERS IN BOOKS
Krige, J.E.J., Bornman, P.C. & Terblanche, J. 1999. In Sivak, M.V. (ed.) Complications of Sclerotherapy. Gastroenterology Endoscopy, 2nd Edition: chapter on CD ROM. Philadelphia: WB Saunders Co. Krige, J.E.J. & Bornman, P.C. 2000. Infections in hepatic biliary and pancreatic surgery. In Blumgart, L.H. & Fong, Y. (eds) Surgery of the Liver and Biliary Tract, 3rd edition 1: 151-166. London, Edinburgh, New York, Philadelphia: WB Saunders Co. Krige, J.E.J. & Terblanche, J. 2000. Endoscopic therapy in the management of esophageal varices: Injection sclerotherapy and variceal ligation. In Blumgart, L.H. & Fong, Y. (eds) Surgery of the Liver and Biliary Tract, 3rd edition 2: 1885-1906. London, Edinburgh, New York, Philadelphia: WB Saunders Co.
CONFERENCE ABSTRACTS
Douie, W.J.P., Bornman, P.C., van Wyk, M., Kidd, M., Johnson, C.D. & Fitzsimmons, D. 2000. Which factors influence quality of life (QoL) in patients with chronic pancreatitis after surgery for intractable pain? Association of Surgeons of South Africa 22nd Biennial Congress Feather Market Center, Port Elizabeth. South African Journal of Surgery 38: 23. Douie, W.J.P., Bornman, P.C., van Wyk, M., Kidd, M., Krige, J.E.J., Beckingham, I. & Terblanche, J. 2000. Is surgery a viable therapeutic option in the management of pain in chronic pancreatitis. Association of Surgeons of South Africa 22nd Biennial Congress Feather Market Center, Port Elizabeth. South African Journal of Surgery Suppl. 38: 18. Goddard, E.A., Spearman, C.W.N., McCulloch, M.I., Millar, A.J.W. & Kahn, D. 2000. Cytomegalovirus (CMV) infection in paediatric liver transplant recipients in a developing country. Paediatric Transplantation 4 (2): 48. Hameed, M.F., Krige, J.E.J. & Nicol, A. 2000. Local complications after surgery for penetrating pancreatic injuries. Surgical Research Society Meeting, Cape Town. Hameed, M.F., Krige, J.E.J. & Nicol, A. 2000. Morbidity of pancreatic resections for trauma. Association of Surgeons of South Africa 22nd Biennial Congress Feather Market Center, Port Elizabeth. Hameed, M.F., Krige, J.E.J. & Nicol, A. 200. What is the morbidity of pancreatic resections for trauma? Association of Surgeons of South Africa 22nd Biennial Congress Feather Market Center, Port Elizabeth. South African Journal of Surgery Suppl 38:15. Krige, J.E.J., Beningfield, S.J., Bornman, P.C. & Terblanche, J. 2000. Percutaneous selective hepatic artery embolization is the treatment of choice for hepatic haemobilia. 4th World Congress, Brisbane Australia. Hepatobiliary International 2:245. Krige, J.E.J., Beningfield, S.J., Bornman, P.C. & Terblanche, J. 2000. Subparietal hepaticojejunal access loop for intrahepatic stones. 4th World Congress, Brisbane Australia. Hepatobilary International 2: 118. Krige, J.E.J., Bornman, P.C. & Terblanche, J. 2000. Pancreatoduodenectomy for complex pancreatic trauma. 4th World Congress, Brisbane Australia. Hepatobiliary International 2: 214. Krige, J.E.J., Bornman, P.C. & Terblanche, J. 2000. Sclerotherapy versus surgery for longterm management of bleeding esophageal varices: Analysis of a prospective randomized controlled trial. 4th World Congress, Brisbane Australia. Hepatobiliary International 2: 274. Krige, J.E.J., Bornman, P.C. & Terblanche, J. 2000. Variceal rebleeding and recurrence after injection sclerotherapy: a prospective evaluation in 204 patients. 4th World Congress, Brisbane Australia. Hepatobiliary International 2: 274. Krige, J.E.J., Douie, W.J.P., Bornman, P.C. & Terblanche, J. 2000. Variceal re-bleeding and recurrence after injection sclerotherapy: a prospective evaluation in 204 patients. South African Journal of Surgery Suppl. 38: 17. Krige, J.E.J., Marr, J.D.F., Bornman, P.C. & Terblanche, J. 2000. Gunshot wounds of the liver. An analysis of 153 cases. 4th World Congress, Brisbane, Australia. Hepatobiliary International 2: 245. 92
Krige, J.E.J., Swart, N., Bornman, P.C. & Terblanche, J. 2000. Liver resection for colorectal metastases. Association of Surgeons of South Africa 22nd Biennial Congress Feather Market Center, Port Elizabeth. South African Journal of Surgery Suppl 38:11. Mall, A., Blows, D., Taylor, K., Tyler, M., Lotz, Z. & Kahn, D. 2000. Is there an association between H heilmannii infection, mucus degradation and ulceration of the pars oesophagea in the bile duct ligated pig? A Pilot Study. Surgical Research Society Meeting, Cape Town. Mall, A., Hall, P., Barnard, R., Ho, S.B., van Rensburg, M. & Kahn, D. 2000. The expression of Mucin in Cholangiocarcinoma. An Immunohistochemical Study. Surgical Research Society Meeting, Cape Town. Mall, A., Suleman, N., Kidd, M., Taylor, K., Tyler, M., Lotz, Z. & Kahn, D. 2000. The incidence of Helicobacter heilmannii in the normal pig stomach. Surgical Research Society Meeting, Cape Town. Mall, A., Suleman, N., Taylor, K., Tyler, M,. Lotz, Z., Kidd, M. & Kahn, D. 2000. Is there an association between H heilmannii infection, mucus degradation and ulceration of the pars oesophagea of the abattoir pig stomach. Surgical Research Society Meeting, Cape Town. McCulloch, M., Andronikou, S., Hoffman, E.B., Goddard, E. & Kahn, D. 2000. Avascular necrosis of the hip in paediatric renal transplant recipients. Paediatric Transplantation 4 (2): 122. McCulloch, M., Gilbert, R., Eley, B., Zuhlke, L., McCurdie, F., Pascoe, M., Pontin, A., Millar, A.J.W. & Kahn, D. 2000. Overview of paediatric renal transplant programme in a developing country. Paediatric Transplantation 4 (2): 103. Millar, A.J.W., Spearman, C.W.N., McCulloch, M., Goddard, L., Rode, H. & Kahn, D. 2000. Paediatric liver transplantation in a developing country – taking stock. Paediatric Transplantation 4 (2): 129. Mirza, K.M., Krige, J.E.J., Beningfield, S., Cullis, P.C. & Terblanche, J. 2000. Longterm management of intrahepatic stones. Association of Surgeons of South Africa 22nd Biennial Congress Feather Market Center, Port Elizabeth. South African Journal of Surgery Suppl. 38:17. Motale, P., Mall, A., Lotz, Z., Tyler, M., Sheperd, E., Hall, P., Hickman, R. & Kahn, D. 2000. The effect of mycophenolate mofetil on liver regeneration. Surgical Research Society Meeting, Cape Town. Rowe, P., Bautz, P.C., Nicol, A. & Kahn, D. 2000. Accuracy of diagnostic tests for haemopericardium. Surgical Research Society Meeting, Cape Town. Spearman, C.W.N., McCulloch, M., Goddard, E., Millar, A.J.W., Hartley, P. & Kahn, D. 2000. Post- transplant lymphoproliferative disease (PLTD) in paediatric liver transplant recipients in a developing country. Paediatric Transplantation 4 (2): 53. Spearman, C.W.N., McCulloch, M., Goddard, E.A., Hartley, B., Prescott, C., Kahn, D. & Millar, A.J.W. 2000. Post transplant lymphoproliferative disease in paediatric liver transplant recipients in a developing country. 1st Congress of the International Pediatric Transplant Association Giorgio Cini Foundation Venice. Swart, N., Douie, W.J.P., Krige, J.E.J. & Bornman, P.C. 2000. Is the training of surgical registrars adequate? Association of Surgeons of South Africa 22nd Biennial Congress Feather Market Center, Port Elizabeth. South African Journal of Surgery Suppl 38: 13. Van Rensburg, M., Krige, J.E.J., Beckingham, I., Bornman, P.C. & Terblanche, J. 2000. Traumatic biliary fistula after liver injury. Association of Surgeons of South Africa 22nd Biennial Congress Feather Market Center, Port Elizabeth. South African Journal of Surgery Suppl 38: 16.
THESES AND DISSERTATIONS PASSED FOR HIGHER DEGREES
Hift, R.J. 2000. Variegate Porphyria. Molecular basis and its biochemical and clinical consequences: 1- 311. Ph.D. thesis, University of Cape Town. Siziba, K. 2000. Expression, purification and characterisation of protoporphyrinogen oxidase from diverse species: 1-202. Ph.D. thesis, University of Cape Town.
UNIVERSITY PUBLICATIONS AND WORKS OF A POPULAR NATURE
Hift, R.J. 2000. Prescribing for patients with liver disease. In Gibbon, C.J. (ed.) South African Medicines Formulary 5th Edition: 15-19. Cape Town: SAMA Health and Medical Publishing Group. Hift, R.J. 2000. Prescribing for patients with porphyria and management of the acute attack. In Gibbon, C.J. (ed.) South African Medicines Formulary 5th Edition: 20-27. Cape Town: SAMA Health and Medical Publishing Group. 93
INVITED TO PARTICIPATE IN JOURNAL DEBATES, PEER EXCHANGE & INSIGHTS INTO MEDICINE
Behrns, K.E., Bornman, P.C., Bradley, E.L., Foxx-Oernestein, A.E., Heider, T.R. & Theodre, N.P. 2000. Acute Pancreatitis and Pseudocyst Controversies in Management. Medical Crossfire General Surgery Ed. 1: 18-31.
94
NEUROLOGY UNIT
HEAD OF UNIT - Associate Professor RW Eastman
CONTACT DETAILS Postal Address: Neurology Unit E8, New Groote Schuur Hospital Observatory, 7925 Cape Town Telephone: SA (21) 404-3198 Fax: SA (21) 406-6251 Email: [email protected]
DEPARTMENTAL PROFILE
Research activity has continued despite a heavy clinical load. The acquisition of state-of-the art digital video and EEG equipment has greatly enhanced the surgical treatment of epilepsy programme, which is unique in South Africa.
A Neurogenetics Clinic (jointly run with the Genetics Dept) in establishing a database of common local neurogenetic disorders, especially the familial neuropathies and spino-cerebellar ataxias.
An acute Stroke Unit is in operation (with the Geriatrics Dept) and is now equiped to high-care standard. A database of all stroke patients presenting to Groote Schuur Hospital has been created. Continuing medical education is now accelerating and the impact of this on medical practice is being investigated. The use of computers in medicine, and specifically to create a multi-media medical teaching course, is a focus of interest.
The Myasthenia Gravis Clinic is rapidly expanding and researching new immuno-therapy approaches to treatment.
STATISTICS
PERMANENT AND LONG-TERM STUDENTS CONTRACT STAFF Associate Professor 1 Neurology Registrars 3 Senior Lecturers (full-time) 3 TOTAL 3 Senior Lecturers (part-time) 1 Lecturer (part-time) 1 TOTAL 6
RESEARCH FIELDS
Assoc. Prof R W Eastman Epilepsy, epilepsy surgery, EMG, EEG Dr B M Kies Epilepsy, Parkinson’s disease, headache, continuing medical education Dr A Bryer Stroke, neuro-genetics, spino-cerebellar ataxia Dr E B Lee Pan Myasthenia gravis, computer-based education, health systems information technology, epilepsy surgery Dr J Heckmann Myasthenia gravis, neuro-immunology, neuro-genetics, HIV-related neuropathies
DISTINGUISHED VISITORS
Prof A Compston University of Cambridge; Multiple sclerosis 95
Prof J Berger University of Kentucky; AIDS Prof W Blume University of Toronto; Epilepsy surgery Prof O Dulac University of Paris; Paediatric epilepsy
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Bryer, A. & Geffen, L. 2000. Stroke - new strategies. South African Medical Journal (CME) 18: 10-12. Bryer, A. & de Villiers, L. 2000. Is CT Scan essential in the diagnosis of stroke. South African Medical Journal 90: 110-112. Kies, B.M. 2000. Therapeutics in Neurology. South African Medical Journal (CME) 18: 436-441. Kies, B.M. 2000. CPD Points System - What doctors think. South African Medical Journal 90: 353- 354.
CONFERENCE ABSTRACTS
Isaacs, M., Lee Pan, E. & Eastman, R. 2000. A Profile of Parkinson Support Group Attenders. NASA Conference, Drakensberg. Kies, B.M. 2000. The CPD Points System: Evaluation and Implementation. NASA Conference, Drakensberg. Kies, B.M. 2000. Women and Epilepsy. SANEL Congress, Cape Town. Swanepoel, A., Lee Pan, E., Heckmann, J. & Tucker, L. 2000. Clinical and Electrophysiological findings in glue sniffing neuropathy. NASA Conference, Drakensberg.
UNIVERSITY PUBLICATIONS AND WORKS OF A POPULAR NATURE
Eastman, R. 2000. Neurology for students, 2nd Edition. Neurology Unit, UCT. Kies, B.M. 2000. Anti-Parkinsonian Agents. In Gibbon, C.J. (ed.) South African Medicines Formulary 5th Edition: 387-392. Cape Town: South African Medical Association Health and Medical Publishing Group. Bryer, A. 2000. Antimigraine preparations. In Gibbon, C.J. (ed.) South African Medicines Formulary 5th Edition: 370-374. Cape Town: South African Medical Association Health and Medical Publishing Group. Eastman, R. 2000. Anti-epileptics. In Gibbon, C.J. (ed.) South African Medicines Formulary 5th Edition: 375-386. Cape Town: South African Medical Association Health and Medical Publishing Group.
96
NUTRITION & DIETETICS UNIT
HEAD OF UNIT - Associate Professor Karen Charlton
CONTACT DETAILS Postal Address: J Floor, OMB Groote Schuur Hospital Observatory, 7925 Cape Town Telephone: SA (21) 406-6534 Fax: SA (21) 448-6815 Email: [email protected] [email protected] (secretary)
DEPARTMENT PROFILE
The Nutrition and Dietetics Unit was established in 1990 and is the only facility to offer postgraduate training in nutrition in the country, and indeed the region of Southern Africa, to enable science graduates to become state-registered dietitians, after following a 2-year postgraduate Bachelor of Science Medical Honours degree course. The Unit attracts mature students from a range of science backgrounds. In addition to the Honours programme, the unit currently also has students registered for Masters’ degrees, by dissertation only.
Associate Professor Charlton is the recipient of a three-year Unifoods Doctoral fellowship which is administered through the Chronic Diseases of Lifestyle Programme at the Medical Research Council. A randomized controlled trial is being undertaken to assess the association between salt sensitivity, potassium supplementation, body composition and blood pressure in black South African subjects.
Important work on determinants of food security in South Africa was undertaken during 2000, in collaboration with Professor Donald Rose from Michigan State University who was awarded a MRC Visiting Scientist Grant to spend 3-months in the Unit. Secondary analysis was conducted on data from 29580 households, collected as part of the 1995 Income and Expenditure Survey by Statistics South Africa. The research findings identified that 43.5% of South African households were in “food poverty” (i.e. could not afford to purchase a basic subsistence diet) in 1995. This type of information is useful to enable prioritisation of nutrition and poverty alleviation interventions.
Vitamin A deficiency is a public health problem in South Africa. Ms. Lindi Sibeko, a South African born Master’s student from McGill University, Canada, spent six months in the Unit to conduct fieldwork for a study to investigate the Vitamin A and nutritional status of infants aged 1 – 6 months in an informal settlement in Cape Town. The association between infant feeding practices, maternal nutritional status and infant micronutrient status was assessed.
A survey of the quality and nutritional adequacy of meals provided to orthopaedic patients at Groote Schuur Hospital was recently undertaken by the Unit. It was found that up to 40% of patients interviewed during the study period, rejected at least one of the meals provided. The nutrient analysis of the meals provided to patients showed that it was inadequate in terms of energy, protein and several micro-nutrients.
In addition to teaching and research activities, the Unit has a comprehensive outreach extension service, run under the auspices of the Nestle Nutrition Resources Centre which is housed within the Unit. Partnerships have been created with communities in Heideveld, Hout Bay, Woodstock and in George. Each year, students conduct a field study on a nutrition topic relevant to the social upliftment of impoverished communities, as identified by community representatives and NGOs. In 2000, the Unit developed a nutrition education component for the Chrysalis project, a three-month residential initiative undertaken by the Dept. of Community Safety in the Western Cape to provide male school-leavers, who are at high risk for involvement in crime, with skills in order to improve job opportunities.
A growing activity of the Nutrition Resources Centre is a telephonic service to the public, with many of the enquiries resulting in collaboration with community projects and expansion into research investigations conducted by honours postgraduate honours students.
97
STATISTICS
PERMANENT AND LONG-TERM STUDENTS CONTRACT STAFF Associate Professor 1 Honours 13 nd Lecturers 2 Honours (2 year) 8 Part-time lecturers 2 M.Sc. 2 Secretarial Staff 1 TOTAL 23 TOTAL 6
RESEARCH FIELDS
Assoc. Professor K Charlton Salt sensitivity and blood pressure in transitional communities; nutrition and successful ageing; nutrition and cognitive functioning; nutritional epidemiology; prevention and management of obesity and other chronic diseases; body composition Mrs M Visser Clinical nutrition; nutritional epidemiology; nutrition and HIV/AIDS; nutritional biochemistry Ms I. Schloss Nutritional status and growth; gastro-enterology; community nutrition
DISTINGUISHED VISITORS
Prof. Donald Rose Dept. Agriculture and Economics, Michigan State University, USA (Recipient of MRC Visiting Scientist Grant): Nutrition economist and nutrition policy consultant Ms. Lindi Sibeko Department of Nutrition, McGill University Canada: Lactation consultant and community dietician Associate Professor Linda Tapsall Wollangong University, Australia: Validations of dietary methodology, metabolic studies on substrate utilization Professor Prakash Shetty London School of Hygiene and Tropical Medicine, United Kingdom: Nutrition in developing countries, body composition and energy expenditive assessment, protein metabolism
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Charlton, K.E. 2000. Nutrition, health and old age: the case of urban South African elderly. South African Journal of Clinical Nutrition 13(S): S31-S38. Charlton, K.E. & Schmidt, M. 2000. Structured, Holistic Approach for Research Planning (SHARP). South African Journal of Clinical Nutrition 13(S): S31-S38. Patel, M., Steyn, K., Bourne, L.T., Charlton, K.E., Jooste, P. & Laubscher, R. 2000. The risk profile for chronic diseases of lifestyle in older black persons of the Cape Peninsula: The BRISK study. South African Journal of Gerontology 9(1): 20-24.
PUBLISHED CONFERENCE PROCEEDINGS
Charlton, K.E. & Luft, F.C. 2000. Hypertension and dietary electrolyte intake. In Geertman, R.M. (ed.) 8th World Salt Symposium, vol 1. Amsterdam: Elsevier Science B.V. Lewandowski, S., Rodgers, A.L. & Schloss, I. 2000. The influence of a high oxalate diet on the risk of calcium oxalate renal stone formation in healthy black and white South Africans. In Rodgers, A.L. (ed.) 9th International Symposium on Urolithiasis, vol 1. Cape Town.
UNIVERSITY PUBLICATIONS AND WORKS OF A POPULAR NATURE
Charlton, K.E. 2000. Vitamins. In Gibbon, C.J. (ed.) South African Medicines Formulary, 5th Edition: 73-84. Cape Town: South African Medical Association Health and Medical Publishing Group: Cape Town. 98
Charlton, K.E. & Visser, M.E. 2000. Nutrition in Medical Practice: A need for nutrition education for medical practitioners. Update May: 68-69. Charlton, K.E. 2000. Nutrition in Medical Practice: Diet and blood pressure: To salt or not to salt? Update June: 73-81. Schloss, I. 2000. Eating right to prevent cancer. Update August. Visser, M.E. & Aginsky, J. 2000. The glycaemic Index (GI): A useful concept in the dietary management of people with Diabetes Mellitus? Update June: 62-67.
CONFERENCE ABSTRACTS
Aginsky, J., Visser, M.E. & Levitt, N.S. 2000. The Inter- and Intra- individual variation in glycaemic and insulin responses to glucose and white bread in healthy male students. Biennial Nutrition Congress of South Africa, Durban. Caradas, A., Lambert, E.V. & Charlton, K.E. 2000. An ethnic comparison of eating attitudes and associated body image concerns in South African schoolgirls. 13th International Congress of Dietetics, Edinburgh, United Kingdom. Caradas, A., Lambert, E.V. & Charlton, K.E. 2000. An ethnic comparison of eating attitudes and associated body image concerns in South African schoolgirls. 36th Society for Endocrinology, Metabolism and Diabetes of South Africa (SEMDSA) Congress, Durban. Charlton, K.E. & Lambert, E.V. 2000. Out of the frying pan… into the fire. Emerging obesity in South Africa. Invited presentation to scientists at Unilever Head Office, Vlaardingen, Netherlands. Charlton, K.E., Lovely, J. & Love, P. 2000. Food Based Dietary Guidelines: One size fits all? Biennial Nutrition Congress of South Africa, Durban. Charlton, K.E. on behalf of the Food Based Dietary Guidelines (FBDG) Working Group. 2000. Food Based Dietary Guidelines: the way forward. Biennial Nutrition Congress of South Africa, Durban. Charlton, K.E., London, L., te Water Naudé, J., Sayed, R., Dausab, M., Marco, C., Rendell, K., Swart, R. 2000. Poverty, alcohol and nutritional status in farmworkers in the Western Cape. Biennial Nutrition Congress of South Africa, Durban. Croucher, L., Schloss, I. & Bourne, L.T. 2000. Nutritional status and infant feeding practices of infants attending Nolungile Day Hospital in Khayelitsha. Biennial Nutrition Congress of South Africa, Durban. Harrison, V., Fawcus, S., de Santos, N., Peat, G. & Charlton, K.E. 2000. The association of maternal magnesium status with hypoxic-ischaemic Encephalopathy of the newborn. 7th World IAMANEH Conference, Stellenbosch. Lambert, E.V., Weitz, W., Charlton, K.E., Lambert, M.I., Kubukeli, Z., Keytel, L., Temple, N. & Daniels, A. 2000. Health and fitness survey in adolescent schoolchildren in the Western Cape: relationship to body mass index and obesity. Biennial Nutrition Congress of South Africa, Durban. Rose, D. & Charlton, K.E. 2000. Food insecurity and food poverty in South African households. Biennial Nutrition Congress of South Africa, Durban. Schloss, I., Huskisson, J., Reay, G., Charlton, K.E., Saitowitz, R., Hendricks, M., Shung King, M., Irlam, J., Hussey, G. & Ernsten, K. 2000. Vitamin A brochure improves knowledge of Primary Health Care (PHC) workers. Biennial Nutrition Congress of South Africa (Poster), Durban. Visser, M.E. 2000. Dietary requirements for people living with HIV/AIDS: enough evidence for specific dietary guidelines? Biennial Nutrition Congress of South Africa, Durban.
UNPUBLISHED RESEARCH/TECHNICAL / POLICY DOCUMENTS:
Te Water Naude, J.M., Charlton, K.E., Sayed, R., Dausab, M., Marco, C., Rendall-Mkosi, K. & London, L. 2000. The Dopstop Association – Promoting health on farms – Stellenbosch, 1998. Health Systems Trust, Charlton, K.E. 2000. Nutrition and ageing in Africa: policy issues. Invited paper at the Organization of African Unity (OAU) Policy Framework on Ageing meeting, Kampala, Uganda.
CONSULTANCIES AND OTHER COMMUNITY ACTIVITIES BASED ON EXPERTISE DEVELOPED IN RESEARCH
Charlton KE: Member of Working Group for Development of National Food Based Dietary Guidelines. Chairperson of Working Group for Development of Dietary Guidelines for Elderly South Africans. 99
Member of Working Group for the Development of National Guidelines on the Prevention and Management of Obesity (Initiative of National Department of Health and South African Society for the Study of Obesity (SASSO)). Member of Nutrition Advisory Committee of Nutrition Directorate of Department of Health: Western Cape. International Union of Nutritional Sciences' (IUNS) Committee on Nutrition and Ageing: member. Member of Scientific Committee: Biennial South African Nutrition Congress 2000. Schloss I: Member of Site Development & Multi-disciplinary Committee (UCT). Visser ME: Member of MBChB curriculum development committee (UCT) Member of National Advisory panel on the Glycaemic Index (GI)
100
RENAL UNIT
HEAD OF DEPARTMENT - Dr MD Pascoe
CONTACT DETAILS Postal Address: Renal Unit E13 Groote Schuur Hospital Observatory 7925 Cape Town Telephone: SA (21) 404-3318 Fax: SA (21) 448-2349 Email: [email protected]
DEPARTMENTAL PROFILE
The department continues to follow many of the same research directions as before. The emphasis on studies in relation to the HI virus and its effect on the kidney continues. Collaboration between the renal unit and the infectious disease group is being developed as well as collaboration with colleagues in the eastern Cape at Umtata and Port Elizabeth. The huge impact of this disease and its effects on the kidney and the implications of this for the provision of renal services are of major importance.
STATISTICS
PERMANENT AND LONG- STUDENTS
TERM CONTRACT STAFF Medical Registrars 3
Associate Professors 3 International Society 1
Senior Lecturers 2 of Nephrology
TOTAL 5 Fellow
TOTAL 4
RESEARCH FIELDS
Dr M D Pascoe Fine needle aspiration biopsy of renal allografts; Renal pathology with HIV disease; Factors influencing long term renal graft survival; Cost effective drug strategies in transplantation - the role of ketoconazole in combination with cyclosporin and tacrolimus; New immunosuppression protocols for renal transplantation Dr J A Halkett Anaemia and iron metabolism in chronic renal failure; Aluminium overload in haemodialysis patients; Acute renal failure Demographics and outcome at Groote Schuur Hospital; Renal pathology with HIV disease; Outcome of haemodialysis treatment for acute renal failure in patients with HIV infection Associate Professor B L Rayner Research activities are based in the hypertension clinic; Nil renal Associate Professor C R Swanepoel Renal Osteodystrophy & Lanthanum carbonate; Hepatitis G & the kidney; Sildenafil & erectile dysfunction in patients with renal disease Associate Professor R van Zyl Smit Genetics of renal disease; chronic renal failure; focal sclerosing glomerulonephritis; proteinuric disease; Lipid abnormalities; post transplantation
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Kahn, D., Botha, J.F., Pascoe, M.D., Pontin, A.R., Halkett, J. & Tandon, V. 2000. Withdrawal of cyclosporine in renal transplant recipients with acute tubular necrosis improves renal function. Transplantation International 13 [Suppl 1]: S82-S83.
101
Pascoe, M.D., Marshall, S.E., Welsh, K.I., Fulton, L.M. & Hughes, D.A. 2000. Increasing the accuracy of renal allograft rejection diagnosis using combined perforin, granzyme B and Fas-ligand fine- needle aspiration immunocytology. Transplantation 69 (12): 2547-2553. Pontin, A.R., Pascoe, M.D., Botha, J.F., Tandon, V. & Kahn, D. 2000. Does rural follow-up of renal allografts give impaired graft survival. Transplantation International [Suppl 1]: S92-S94. Taal, M.W. & van Zyl-Smit, R. 2000. Hepatitis C virus infection in chronic haemodialysis patients-- relationship to blood transfusions and dialyser re-use. South African Medical Journal 90(6): 621- 625. Tandon, V., Botha, J.F., Banks, J., Pontin, A.R., Pascoe, M.D. & Kahn, D. 2000. A Tale of two kidneys. How long can a kidney transplant wait. Clinical Transplantation 14 (3): 189-192. Van Zyl-Smit, R., Mills, P. & Vogelpoel, L. 2000. Unrecognized acute renal failure following the comrades marathon. South African Medical Journal 90(1): 39-40.
CONFERENCE ABSTRACTS
Fisher, G., Twahir, M., Pascoe, M.D. & Halkett, J.A. 2000. Haemodialysis therapy for acute renal failure in patients with retroviral disease. XXIIth Congress of the South African Renal Society and XXth Congress of the Renal Care Society of South Africa, Somerset West. Halkett, J. 2000. European survey of anaemia management (ESAM): The South African data. XXIIth Congress of the South African Renal Society and XXth Congress of the Renal Care Society of South Africa, Somerset West. Halkett, J.A. 2000. Approach to anaemia in the chronic renal failure patient. Renal Management Update, SA Renal Society Meeting. Maree, M. & Halkett, J.A. 2000. The use of low calcium dialysate in hypercalcemic haemodialysis patients. XXIIth Congress of the South African Renal Society and XXth Congress of the Renal Care Society of South Africa, Somerset West. Pascoe, M., Halkett, J., Findlayson, J. & Davies, Y. 2000. Fine needle aspiration cytology, early evaluation of a clinical role. XXIIth Congress of the South African Renal Society and XXth Congress of the Renal Care Society of South Africa, Somerset West. Pascoe, M.D. 2000. New drugs in renal transplantation. Renal Management Update, SA Renal Society Meeting. Rayner, B.L. 2000. Peritoneal Dialysis - the Cape Town experience. XXIIth Congress of the South African Renal Society and XXth Congress of the Renal Care Society of South Africa, Somerset West. Rayner, B.L. 2000. The use of computers in the peritoneal dialysis unit. XXIIth Congress of the South African Renal Society and XXth Congress of the Renal Care Society of South Africa, Somerset West. Rayner, B.L., Hollander, M. & Willett, C. 2000. Nutritional assessment and adequacy of dialysis in CAPD patients. XXIIth Congress of the South African Renal Society and XXth Congress of the Renal Care Society of South Africa, Somerset West. Stead, P., Halkett, J., Kahn, D. & Pascoe, M. 2000. Long-term renal transplant survivors at Groote Schuur hospital. XXIIth Congress of the South African Renal Society and XXth Congress of the Renal Care Society of South Africa, Somerset West. Swanepoel, C. & Gerntholtz, T. 2000. The use of sildenafil for erectile dysfunction in patients with renal disease. XXIIth Congress of the South African Renal Society and XXth Congress of the Renal Care Society of South Africa, Somerset West. Swanepoel, C. 2000. Preventable nephropathy. Renal Management Update, SA Renal Society Meeting. Twahir, M., Halkett, J., Duffield, M. & Pascoe, M. 2000. A five year retrospective study of renal biopsy diagnosis in HIV positive patients in Groote Schuur hospital, Cape Town South Africa. XXIIth Congress of the South African Renal Society and XXth Congress of the Renal Care Society of South Africa, Somerset West. Van Zyl Smith, R. 2000. Lipid abnormalities in patients with renal disease. Renal Management Update, SA Renal Society Meeting.
UNIVERSITY PUBLICATIONS AND WORKS OF A POPULAR NATURE
De Tout, E., Pascoe, M.D. & Thomson, P. 2000. Combined report on Maintenance Dialysis and Transplantation in the Republic of South Africa (1998). South African Dialysis and Transplant Registry (SADTR). Pascoe, M.D. 2000. The Cape Gliding Club - The first 50 years. Red Roof Publishing.
102
RESPIRATORY CLINIC
HEAD OF DEPARTMENT – Professor ED Bateman
CONTACT DETAILS Postal Address: UCT Lung Institute PO Box 34560 Groote Schuur 7937 Cape Town Telephone: SA (21) 406-6901 Fax: SA (21) 406-6902 Email: [email protected] Webpage: http://www.uct.ac.za/depts/respiratory/
DEPARTMENTAL PROFILE
The main clinical service areas of the Respiratory Clinic are the outpatients clinic and the Respiratory Intensive Care Unit located in Groote Schuur Hospital. Its base for research and expanded clinical service is the UCT Lung Institute. The Institute is located in a new purpose designed four-storey building on the Health Sciences Faculty campus officially opened in April 2000. In addition, clinic staff provide a consultancy service at secondary hospitals including the regional tuberculosis hospitals. Research and academic activities extend beyond this, and members of staff are highly specialised in different aspects of respiratory and critical care medicine and allergology and make notable contributions to the development of public policy, professional societies and local and international academic activities and research in these fields. In the Lung Institute, the Lung Clinical Research Unit is one of 5 units involved in collaborative activities, the others being an Allergology and Diagnostic Unit, an Occupational Health Unit, an Infectious Diseases Unit and a Skin Centre. Together these units share the goal of promoting lung health and improving the treatment of respiratory and related diseases in Southern Africa.
STATISTICS
PERMANENT AND LONG RESEARCH STAFF
TERM CONTRACT STAFF Medical Officers 3 Professor 1 Nursing study co- 7 Associate Professors 3 ordinators Senior Lecturers 1 Research Assistants 2 TOTAL 5 Admin and Clerical 2 Staff TOTAL 14 TECHNICAL SUPPORT STAFF Chief Technologist 1 STUDENTS Principal Technologist 1 Doctoral M.D./Ph.D. 3 TOTAL 2 M.Med: FCP 4 M.Sc. 1 TOTAL 8
RESEARCH FIELDS
Professor E.D. Bateman Disease management, pharmacology, and epidemiology of asthma and chronic obstructive pulmonary disease; classification and treatment of diffuse parenchymal lung diseases; treatment of tuberculosis Associate Professor G.M. Ainslie Clinical features and treatment of sarcoidosis; treatment of cryptogenic fibrosing alveolitis; cryptogenic organising pneumonia; clinical patterns of asthma; alpha1-antitrypsin deficiency
103
Dr R.I. Raine Airway management in critical care; septic shock; antimicrobial therapy in candidaemia; analgesia and sedation in critical care; the role of surfactant administration in the management of ARDS; prognostic indicators in critical care Associate Professor N.W. White Lung disease in ex-miners; epidemiology of silicosis in gold miners; lung function reference equations; tuberculosis in miners; occupational asthma; radiological classification of pneumoconiosis; effects of air pollution upon the health of children Associate Professor P.A. Willcox Multi-drug-resistant tuberculosis; lung cancer; cystic fibrosis; community-acquired pneumonia; nocardial infections; bacterial endocarditis Dr H Zar Gastro-oesophageal reflux in asthma; near-fatal and fatal asthma
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Bateman, E.D., Adler, L., Chyrek-Borowska, S., Theman, K., Rogeaux, Y., Schultze-Werninghaus, G., Nel, A.M., Pasquet, J-P., Notelet, D., Hardy, P., Petillo, J. & Banerji, D. 2000. Inhaled Triamcinolone acetonide HFA 450µg twice daily compared with beclomethasone dipropionate CFC 500µg twice daily in adults with moderate persistent asthma. Clinical Drug Investigation 20: 1-9. Bateman, E.D. 2000. Salmeterol/fluticasone propionate combination. Guest commentary. Drugs 57: 941-943. Lalloo, U.G., Bateman, E.D., Feldman, C., Bardin, P.G., Plit, M., Irusen, E.M. & O’Brien, J. 2000. Guidelines for the management of chronic asthma in adults - 2000 Update. For the South African Pulmonology Society Adult Asthma Working Group. South African Medical Journal 90: 540- 552. Willcox, P.A. 2000. Drug-resistant tuberculosis. Current Opinions in Pulmonary Medicine 6: 198-202. Zar, H.J. & Bateman, E.D. 2000. Near-fatal asthma – a review. South African Journal of Critical Care 16: 5-9.
CHAPTERS IN BOOKS
Lewis, S.J., Ainslie, G.M. & Bateman, E.D. 2000. Efficacy of azathioprine as second-line treatment in Pulmonary sarcoidosis. In The Golden Book: Sarcoidosis 1994/1999: 176-181. Fidenza (Parma): Casa Editrice Mattioli.
CONFERENCE ABSTRACTS
Ainslie, G.M. & Bateman, E.D. 2000. Natural history of patients presenting with chest radiographic Stage 4 pulmonary sarcoidosis. European Respiratory Journal 16: 390s. World Lung Health Congress, Florence, Italy. Ainslie, G.M. & Latib, M.A. 2000. The concordance of different criteria for asthma severity as proposed by the SAPS Guidelines. South African Respiratory Journal 6:84. COMCO: Combined Congress of the Critical Care Society of South Africa and the South African Pulmonology Society, Durban. Ainslie, G.M. & Bateman, E.D. 2000. Natural history of patients presenting with chest radiographic Stage 4 pulmonary sarcoidosis. South African Respiratory Journal 6: 84. COMCO: Combined Congress of the Critical Care Society of South Africa and the South African Pulmonology Society, Durban. Bateman, E.D., Jenkins, C., Woolcock, A. & Sykes, J. 2000. ‘Total’ asthma control with salmeterol/ fluticasone propionate (FP) combination compared with budesonide at a higher microgram steroid dose. South African Respiratory Journal 6: 86 . COMCO: Combined Congress of the Critical Care Society of South Africa and the South African Pulmonology Society, Durban. Bateman, E.D., Poyser, M., Zar, H.J. & Parnell, S. 2000. Correlation between fear fatal and fatal asthma attacks and socio-economic deprivation in Cape Town South Africa. South African Respiratory Journal 6: 86. COMCO: Combined Congress of the Critical Care Society of South Africa and the South African Pulmonology Society, Durban. Bateman, E.D., Notelet, D., Francois, M.H., Hardy, P. & Banerji, D. 2000. Once daily regimen of triamcinolone acetonide (TAA) HFA inhalation aerosol maintains asthma control in adults. European Respiratory Journal 16:34s. World Lung Health Congress, Florence, Italy. 104
Bateman, E.D., Notelet, D., Francois, M.H., Hardy, P. & Banerji, D. 2000. Once daily regimen of triamcinolone acetonide (TAA) HFA inhalation aerosol maintains asthma control in adults. South African Respiratory Journal 6: 86. COMCO: Combined Congress of the Critical Care Society of South Africa and the South African Pulmonology Society, Durban. Bateman, E.D. & Kruger, M.J. 2000. A computer-based home-monitoring disease management programme, PulmAssist Plus (PAP), achieves significant improvement in quality of life, and healthcare costs in moderate and severe asthma. American Journal of Respiratory and Critical Care Medicine 161:s. International Conference of the American Thoracic Society, Toronto, Canada. Bateman, E.D. & Kruger, M.J. 2000. Improvements in prescriptions and healthcare utilisation in patients with moderate or severe asthma enrolled in a 12 month study with the Pulmassist® Plus (PAP) disease management programme. American Journal of Respiratory and Critical Care Medicine 161:s. International Conference of the American Thoracic Society, Toronto, Canada. Bateman, E.D. 2000. Comparison of salmeterol/ fluticasone propionate combination 50/100 BID delivered via metered dose inhaler or diskus in patients with reversible airways obstruction. American Journal of Respiratory and Critical Care Medicine 161:s. International Conference of the American Thoracic Society, Toronto, Canada. Bateman, E.D., Poyser, M., Zar, H.J. & Parnell, S. 2000. Correlation between near-fatal and fatal asthma attacks and socio-economic deprivation in Cape Town, South Africa. European Respiratory Journal 16:368. World Lung Health Congress, Florence, Italy. Bateman, E.D., Johansson, G. & Drake, F. 2000. Comparable overall control of moderate asthma with salmeterol/fluticasone propionate (FP) combination (50/100 mcg bd) compared with a four-fold higher dose of budesonide (400 mcg bd). European Respiratory Journal 16:456s. World Lung Health Congress, Florence, Italy. Bateman, E.D., Jenkins, C., Woolcock, A. & Sykes, J. 2000. ‘Total’ asthma control with salmeterol/fluticasone propionate (FP) combination compared with budesonide at a higher microgram steroid dose. European Respiratory Journal 16:457s. World Lung Health Congress, Florence, Italy. Darmalingam, M., Ainslie, G.M., Goodman, H., Wainwright, H. & Bateman, E.D. 2000. Lack of correlation between high resolution computer tomography and surgical lung biopsy in idiopathic pulmonary fibrosis. South African Respiratory Journal 6:90. COMCO: Combined Congress of the Critical Care Society of South Africa and the South African Pulmonology Society, Durban. Latib, M.A. & Ainslie, G.M. 2000. Potential for improvement in the management of asthmatic patients referred to a tertiary hospital. South African Respiratory Journal 6:101. COMCO: Combined Congress of the Critical Care Society of South Africa and the South African Pulmonology Society, Durban. Poyser, M., Ehrlich, R., Nelson, H., Parnell, S. & Bateman, E.D. 2000. Association between asthma prevalence and socio-economic deprivation in the 1995 Cape Town ISAAC Study. South African Respiratory Journal 6:86. COMCO: Combined Congress of the Critical Care Society of South Africa and the South African Pulmonology Society, Durban. Stead, P.A. & Ainslie, G.M. 2000. Organising pneumonia pattern at Groote Schuur Hospital. South African Respiratory Journal 6: 107. COMCO: Combined Congress of the Critical Care Society of South Africa and the South African Pulmonology Society, Durban. Venter, J.A., Stead, P.A. & Raine, R.I. 2000. Type IV renal tubular acidosis presenting as rapidly progressive flaccid paralysis. South African Respiratory Journal 6:110. COMCO: Combined Congress of the Critical Care Society of South Africa and the South African Pulmonology Society, Durban. Venter, J.A., Willcox, P.A. & Roditi, D. 2000. The development of quinolone resistance in Pseudomonas aeruginosa infections in adult patients with cystic fibrosis. Cystic Fibrosis Congress, Sun City. White, N.W., Ehrlich, R.I., Abdullah, I. & Herman, C. 2000. Asbestos related diseases among electrical power generation workers in South Africa. South African Respiratory Journal 6:112. COMCO: Combined Congress of the Critical Care Society of South Africa and the South African Pulmonology Society, Durban. White, N.W. 2000. Respiratory Health in South Africa: results of the 1998 Demographic and Health Survey. South African Respiratory Journal 6:112. COMCO: Combined Congress of the Critical Care Society of South Africa and the South African Pulmonology Society, Durban. White, N.W. 2000. Validation of a radiological classification of thoracic tuberculosis for use in conjunction with the ILO Radiological Classification of the Pneumoconioses. South African Respiratory Journal 6:113. COMCO: Combined Congress of the Critical Care Society of South Africa and the South African Pulmonology Society, Durban.
105
Zar, H.J., Hanslo, D., Apolles, P., Tannenbaum, E., Eley, B., Klein, M., Argent, A., Burgess, J., Magnus, K., Bateman, E.D. & Hussey, G. 2000. Aetiology and outcome of pneumonia in HIV- infected children admitted to hospital in South Africa. South African Respiratory Journal 6:114. COMCO: Combined Congress of the Critical Care Society of South Africa and the South African Pulmonology Society, Durban. Zar, H.J., Toerien, A., Stickells, D., Wilson, D., Klein, M. & Bateman, E.D. 2000. Changes in asthma mortality and morbidity in Cape Town, South Africa from 1980 – 1997. American Journal of Respiratory and Critical Care Medicine 161:s. International Conference of the American Thoracic Society, Toronto, Canada.
THESES AND DISSERTATIONS PASSED FOR HIGHER DEGREES
Zar, H.J. 2000. Pneumonia in HIV-Infected Children Admitted to Hospital in Cape Town, South Africa. (Jointly with Department of Paediatrics). Ph.D. thesis, University of Cape Town.
UNIVERSITY PUBLICATIONS AND WORKS OF A POPULAR NATURE
Ainslie, G.M. 2000. Interstitial Lung Disease: current perspectives and challenges. South African Respiratory Journal 6: 43. Ainslie, G.M. 2000. Cryptogenic Organising Pneumonia. South African Respiratory Journal 6: 66-71. Ainslie, G.M. 2000. An approach to the diagnosis of interstitial lung disease. Specialist Medicine XXII: 444-450.
CONFERENCE ABSTRACTS
Venter, J.A., Willcox, P.A. & Roditi, D. 2000. The development of quinolone resistance in Pseudomonas aeruginosa infections in adult patients with cystic fibrosis. Cystic Fibrosis Congress, Sun City. Willcox, P.A. 2000. HIV and Tuberculosis. South African Pulmonology Society Continuing Medical Education Congress, Durban.
CONSULTANCY AND OTHER ACTIVITIES
Professor E. D Bateman Elected President of the South African Thoracic Society. Elected Member of the Communications Committee of the American Thoracic Society Core Member of the International Committee drafting a Consensus Document on the Classification of Interstitial Lung Disease. Invited advisor on research to the Brewelskloof Tuberculosis Hospital. Consultant to Partners-in-Healthcare in developing a computer programme for the diagnosis and management of asthma and chronic obstructive lung disease. Invited speaker at meetings arranged by the Chinese Thoracic Society in Taiwan in March. Invited speaker at Chinese Respiratory Society Congress in Nanking, China, in October . Invited speaker at Respiratory Healthcare Decision-Makers Workshop, Rome, Italy, in November. Invited speaker at Respiratory Physicians’ Specialist Symposium Barcelona, Spain in November. Serves on several South African Advisory Boards for new therapeutic interventions. Invited speaker at the Annual International Congress of the American Thoracic Society in Toronto in April. Invited speaker at symposia at the World Lung Health Congress in Florence, Italy in September. Invited speaker at the International Influenza Consultants Meeting, arranged by the R. W. Johnson Pharmaceutical Research Institute in Paris in May. Invited speaker at COMCO, the combined meeting of the South African Pulmonology Society and the Critical Care Society of Southern Africa held in Durban in July. Invited speaker at the Asthma Control Workshop, Lisbon, Portugal in February and at a Satellite Symposium in San Diego, USA in March. Visiting Professor and invited lecturer at the Firestone Institute for Respiratory Health, McMaster University, Hamilton, Ontaria, Canada in May. Serves as Director of the UCT Lung Institute. As head of the Lung Clinical Research Unit he participated in 21 sponsored clinical trials involving drugs for asthma, chronic obstructive pulmonary disease, influenza, multi-drug resistant tuberculosis, idiopathic pulmonary fibrosis and bronchitis. 106
Regular reviewer for 13 medical journals. Associate Professor G A Ainslie Elected National Chair of National Asthma Education Programme. Elected member of Council of South African Thoracic Society. Attended as South African representative at a meeting of the Alpha-1 Anti-Trypsin Deficiency International Registry in Florence in August. Presented papers at the South African Pulmonology Society Congress in Durban in July, and at the World Lung Health Congress in Florence in September. Organised and presented at the Continuing Medical Education Workshop on Interstitial Lung Disease (South African Pulmonology Society) in Durban in July. Dr. R.I. Raine Medical volunteer in Red Cross Mercy Air Service. Elected member of Council of the Critical Care Society of Southern Africa. Associate Professor P A Willcox Invited speaker at the Brewelskloof Tuberculosis Conference, Worcester in August , at the South African Pulmonology Society Continuing Medical Education Congress in September, and at the Botswana Medical and Dental Congress in Francistown in October. Elected a member of the Editorial Board of the Malawi Medical Journal. Reviewer for the South African Medical Journal and the Central African Journal of Medicine. Involved in research contracts on novel treatments in multi-drug-resistant tuberculosis and community-acquired pneumonia. Served as external examiner for the College of Medicine, Malawi (final year medicine) and for the University of Zimbabwe (final year medicine and master of medicine candidates). Associate Professor N White Invited speaker at the Continuing Medical Education Workshop on Interstitial Lung Disease in Durban in July (South African Pulmonology Society). Awarded best poster presentation at the COMCO Congress in Durban in July. Member of the Scientific Committee for the 2000 Africa Region Congress of International Union against Tuberculosis and Lung Disease (IUAT-LD), Conacry. Member of the Mining and Occupational Health Advisory Committee (MOHAC). Reviewer for the Scientific Committee of the World Lung Health Congress held in Florence, Italy in September. Collaborative researcher in mining-related projects funded by SIMRAC, in collaboration with Aurum Health Research (Pty) Ltd, the University of Natal, the National Centre for Occupational Health, Johannesburg and the Department of Public Health, UCT.
107
RHEUMATIC DISEASES UNIT
HEAD OF DEPARTMENT - Associate Professor Asgar Ali Kalla
CONTACT DETAILS Postal Address: J47 Old Main Building Groote Schuur Hospital Observatory, 7925 Cape Town Telephone: SA (21) 404-5422 / 404-2131 / 406-6514 Fax: SA (21) 448-3253 Email: [email protected]
DEPARTMENTAL PROFILE
The Rheumatic Diseases Unit has several research interests relating to different aspects of the rheumatic diseases. Corticosteroid induced osteoporosis is an area of interest for many years and we are currently collecting longitudinal bone mineral density data in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Age-related bone loss at different skeletal sites is also being prospectively studied in collaboration with the Department of Nuclear Medicine and the Endocrine Unit. We are analysing the results of SPECT scans in SLE patients developing signs and symptoms of neuropsychiatric SLE. Clinical drug trials are being conducted to study the safety and efficacy of the newer non steroidal anti inflammatory drugs (NSAIDS), the class of COXIBS, in patients with RA and osteo arthritis (OA). Some of these include collaborative participation with the GIT Unit, where gastropathy is an outcome variable. The genetic basis for SLE is being looked at with respect to potential candidate genes.
The unit provides in- and outpatient rheumatology services for the entire Western Cape region. Training is provided on a continuous basis for medical students, allied health professionals, a senior house officer, and two registrars. Research is both clinically and laboratory based. In this regard, collaborative arrangements are in place with the Rheumatic Diseases Hospital in Bath, UK.
STATISTICS
PERMANENT AND LONG-TERM HONORARY STAFF STUDENTS CONTRACT STAFF
Associate Professor 1 Honorary lecturers 3 Medical Officers 2
Senior Lecturer 1 TOTAL 3 TOTAL 2
Lecturer 1
Research Staff 2 Administrative and Clerical 1 Staff TOTAL 6
RESEARCH FIELDS
Prof. AA Kalla Osteoporosis; steroid-induced osteoporosis; disease modification of RA Dr YI Patel Apoptosis and auto-immunity, genetics of SLE Dr C Spargo Neuropsychiatric Lupus Erythematosus Sr GMM Hepburn-Brown Methotrexate in rheumatoid arthritis
108
DEPARTMENT OF NEUROSURGERY
HEAD OF DEPARTMENT - Professor Jonathan Peter
DEPARTMENTAL CONTACT DETAILS
Postal address: H-53, Old Main Building Groote Schuur Hospital Observatory 7925 South Africa Telephone: SA (21) 406-6213/4 Fax: SA (21) 406-6555 e-mail: [email protected] [email protected]
DEPARTMENTAL PROFILE
The department continues to offer a comprehensive neurosurgery service to the people of the Western Cape. Our expertise in the field of interventional neurovascular surgery has been enhanced by the attendance of Dr Allan Taylor at the Neuro-interventional Course offered by Professor Lasjaunias in Malaysia together with the University of Paris. It is his intention to develope this service with the Department of Radiology. Dr Graham Fieggen attended courses in endoscopic neurosurgery in Germany and has developed this aspect of our service to include both children and adults.
Clinical and laboratory research continues in the field of vascular, spinal, pituitary, paediatric neurosurgery and epilepsy surgery.
Our operative work has been greatly enhanced by the acquisition of the Opympus Neurosurgical Microscope from George. The department is grateful to Dr MacMahon's help in this regard. Dr Taylor's costs have been funded by the Taeuber Management Trust who have committed themselves to helping with a development programme for the Neurosurgery Department.
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG TERM STUDENTS CONTRACT STAFF Professors 1 Doctoral 2 Senior Lecturers 3 Masters 6 Lecturers 1 Undergraduate (part of IV & V yr Research Staff 1 MBChB Registrars 6 physiotherapy) teaching Medical Officer 1 TOTAL 8 Nursing Sister 1 Administrative & Clerical Staff 2 TOTAL 16
HONORARY STAFF
Emeritus Professor 1 TOTAL 1
109
RESEARCH FIELDS
PERMANENT STAFF
Professor Jonathan Peter Head of Department; Dysraphism, spasticity in cerebral palsy; Epilepsy surgery; Posterior fossa tumours in children; Hydrocephalus; CNS infection; Head trauma Dr Patrick Semple Snr Specialist; Pituitary disease, Head trauma, Vascular surgery Dr Allan Taylor Snr Specialist; Vascular surgery, Intraventricular haemorrhage in premature babies, Stereotactic surgery, Neuronavigational technology development, and Skull Base surgery Dr Graham Fieggen Snr Specialist - Paediatric Neurosurgeon; Dysraphism, Stereotactic surgery, Head Trauma, Epilepsy surgery and Paediatric Oncology
HONORARY PROFESSORS
Professor Jacquez Charl de Villiers Honorary Consultant; Pituitary disease
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Peter, J.C. & Fieggen, G. 1999. Congenital malformation of the brain- a neurosurgical perspective at the close of the twentieth century. Child’s Nervous System 15: 635-645. Peter, J.C. 1999. The Department of Neurosurgery of the University of Cape Town. Neurosurgery 45(5): 1228-1233.
CHAPTERS IN BOOKS
Domingo, Z., Fisher-Jeffes, N.D. & De Villiers, J.C. 2000. Surgical Management of Arteriovenous Malformations of the Scalp. In Schmidek, J.J. & Sweet, W.H. (eds) Operative Neurosurgeical Techniques , 2nd Edition Vol 2. Philadelphia: W.B. Saunders.
UNIVERSITY PUBLICATIONS AND PUBLICATIONS OF A POPULAR NATURE
Benatar, S.R., Fleischer, T.E., Peter, J.C. & Taylor, A.G. 2000. Editorial. Treatment of head injuries in the public sector in South Africa. South African Medical Journal 90: 790-793. De Villiers, J.C. 2000. French Humanitarian Contributions During the Anglo-Boer War. Bulletin of the Huguenot Society of South Africa 36:9935-9938. De Villiers, J.C. 2000. The origins and early use of radiology in South Africa. SA Journal of Radiology: 12-19. De Villiers, J.C. 2000. Aspects of surgery during the Anglo-Boer War. Transactions of the Medical Society of London 115:27-37. Semple, P.L., Vance, M.L., Findling, J. & Laws, E. 2000. Transsphenoidal Surgery for Cushing’s Disease: Outcome in Patients with a Normal Magentic resonance Imaging Scan. Neurosurgery 46(3).
110
DEPARTMENT OF NUCLEAR MEDICINE
ACTING HEAD OF DEPARTMENT - Professor S. Beningfield
DEPARTMENTAL CONTACT DETAILS Postal address: Department of Nuclear Medicine C3 New Groote Schuur Hospital Observatory 7925 Telephone: SA (21) 404-4169 Fax: SA (21) 404-3402 Email: [email protected]
DEPARTMENTAL PROFILE
Ongoing projects include:
• Bone scans and ERNAS on patients with cancer of the breast and prostate who are on various treatment protocols • Ventilation/perfusion lung scans in patients who are part of a multi institution trial using a new anti - coagulant following DVT or pulmonary embolus. • GFR studies in patients receiving therapy for carcinoma. • Bone mineral density scans for the department of gastro enterology.
DEPARTMENTAL STATISTICS 2000
PERMANENT STAFF
UCT/CPA JOINT STAFF PAWC STAFF
Senior Lecturers 1 Radiographers 7 TOTAL 1 Osteodensitometrist 1 Medical Technologist 1 TOTAL 9
STUDENTS
Masters 1 TOTAL 1
RESEARCH FIELDS
PERMANENT STAFF
Dr A B Fataar Senior Lecturer; osteodensitometry; bone scintigraphy; cerebral perfusion etc Mrs L Bewerunge Osteodensitometrist; research co ordinator Miss G Boltman Chief Radiographer; part time lecturer & network user administrator; cell labelling; radiation protection Mr J Boniaszczuk Chief Radiographer & part time lecturer; instrumentation; quality control Mrs P Freedman Chief Radiographer & part time lecturer; gastric emptying; colonic transit 111
Mrs G Philotheou Radiography Fulltime Lecturer; distance education
RESEARCH OUTPUT
CONSULTANCY
Dr A.B. Fataar and Ms G. Boltman visited Windhoek Hospital in Namibia as part of the IAEA (International Atomic Energy Agency) assessment of various Nuclear Medicine facilities. Mrs P. Freedman and G. Philotheou visited Uganda, Kenya and Sudan under the same programme. Miss G. Boltman went on a scientific visit to London & Oxford to observe techniques in breast and SPECT brain imaging under the auspices of the IAEA. Ms G. Boltman, P Freedman and G. Philotheou were involved in the organising of the S.A. Society of Radiographers 15th Annual Congress in Cape Town in September 2000. Presentations at this congress made by Dr A. Fataar, P.F. Freedman, G. Boltman and J. Boniaszczuk and G.M. Philotheou. P. Freedman presented a poster on colonic transit in spinal cord injuries at the Society of Nuclear Medicine Congress in April 2000 in Bloemfontein.
112
DEPARTMENT OF NURSING
ACTING HEAD OF DEPARTMENT – Associate Professor S.E. Clow
DEPARTMENTAL CONTACT DETAILS Postal address: Department of Nursing University of Cape Town Anzio Road Observatory 7925 South Africa Telephone: SA (21) 406-6319 Fax: SA (21) 406-6497 Email: [email protected]
DEPARTMENTAL PROFILE
A major event in the life of the Department of Nursing was the early retirement of Professor Rosalie Thompson, who has been associated with this department for 27 years, and Professor and Head for the past 18 years. Her considerable contribution to nursing at this university and further afield will be greatly missed. Probably her most important contribution was that of entirely redesigning the undergraduate Bachelor of Nursing programme in 1984 to one that was health based recognising the whole person within the context of the family and wider community. This approach was well in advance of the development towards a primary health care based approach in national health policy and in the curriculum approach of the Faculty of Health Sciences. This courageous initiative was also brought to bear on her work with the South African Nursing Council on which she served two terms as an active member of the education committee and latterly the executive committee.
It is often said of Nursing that it is the backbone of the health service. As nurses are the professional group closest to the population in terms of demography and accessibility, they have the potential to play a substantial role in transformation. Nursing however is not only about systems and structures, but has at its heart a commitment to caring within the context of relationship. A nurse without this commitment and skill is, at best, a skilled technician, and perhaps it is the recognition of this lack of commitment to caring that has resulted in widespread disenchantment with nurses by the South African public over the past few years. This central characteristic of caring needs to be reclaimed and developed. However this does not happen in a haphazard way.
40% of our population is under the age of 15 years. This is a priority and poses a major challenge to education and training of nurses and health care professionals in this country and beyond our borders as well. Dr Minette Coetzee, who is a child nurse, was awarded her PhD in December 2000 for her thesis entitled ‘Learning to engage children : towards a model for undergraduate students in nursing – a grounded theory study. This thesis arose from an interest in understanding how undergraduate students learn in the practice-based discipline of nursing, especially when working with very vulnerable children. The specific contribution of this research is that it makes the complex, and often hidden, process of learning to nurse children visible. Her conceptual model describes the processes that students use as they interact and work with children and their families. The thesis contributes to the theoretical base of experiential learning and has relevance in the international arenas of both nursing and education.
Inadequate staffing continues to be a limiting factor in both teaching and research. Academic staff have had difficulty in meeting their research and publication goals due to the heavy teaching and clinical supervision loads. Academic staff contribute at all levels of the profession and to the health service in general, but need to further develop the department’s research expertise to support nurses in evidence- based practice. Current contributions to the national debates are in the area of changing legislation governing nursing practice, the formation of a standards generating body for nursing and midwifery, and management preparation of nurses for district level practice.
113
There were five Masters graduates in 2000 - the largest haul in a single year. Tanya Doherty who was awarded the degree cum laude is currently studying at Harvard on a Fulbright Scholarship. Three of the graduates of 1999 were awarded the Juta research award for the best undergraduate nursing research in the country – the fifth time in seven years that this award has been awarded to UCT students.
The Department of Nursing introduced a Bachelor of Nursing programme for registered nurses in 1999. The envisaged product of such a programme is a set of graduates groomed for leading the nursing profession into the 21st century. The changing economy and the financial pressure on the health services have had the effect of reducing the viability of a one-year study leave option for professional nurses to further their education. It is thus imperative that nursing education adapt to the needs of the practising nurse, and the department has therefore introduced this part-time, flexible, modular degree programme for professional nurses. This is a first in this university and in this region at the undergraduate level. It also incorporates the principles of recognition of prior learning, in line with SAQA, as recognition is given for diplomas in nursing. There is potential for this programme to be further developed as a dual mode programme i.e. both residential and distance options.
The programme also enables students to elect certain pathways that will lead to additional professional registration with the South African Nursing Council eg Child Nursing, Critical Care Nursing, Nursing Management and Advanced Midwifery. This year, the first four graduates completed the degree in record time one of whom obtained the degree with distinction. Two of the graduates also obtained their qualifications as nurse educators.
The Department of Nursing, in collaboration with the Groote Schuur Hospital Nursing Division, convened the sixth annual Road to Research in August 2000. This activity is an outworking of the department’s commitment to fostering nursing research, and of developing a research ethic and capacity beyond the confines of the department, as well as building opportunities for future collaboration.
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG TERM STUDENTS
CONTRACT STAFF
Professors 1 BN for RN 56
Associate Professors 1 Masters 19
Senior Lecturers 3 Ph.D. 1 Part-time Senior Lecturers 1 TOTAL 76 Administrative staff 2
TOTAL 8
RESEARCH FIELDS
PERMANENT STAFF
Professor R.A.E Thompson The meaning of health; mature women’s health; domestic worker women; nursing education Associate Professor S.E Clow Acting Head of Department; midwifery; women’s health; vacuum extraction deliveries by midwives; Safe Motherhood Initiative; political violence and health; domestic worker women; health policy Dr M Coetzee Senior Lecturer; children’s nursing; nursing education; children of domestic worker women Mrs R.B Hill Senior Lecturer; quality assurance; business process reengineering; change management; forensic nursing; medico-legal issues Mrs P.M Mayers Senior Lecturer; mental health; chronic fatigue syndrome
PART-TIME CONTRACT STAFF
Mrs U Kyriacos Ethics, nursing education patient compliance following open heart surgery for valve replacement
114
DISTINGUISHED VISITORS
Dr K Carr Vice President, American College of Nurse-Midwives. People to People Midwifery delegation leader Janet Selway Johns Hopkins University of Nursing. People to People Nurse Practitioner delegation leader Dr Nancy Bryant Aga Kahn University, Karachi Pakistan Dr Monica Habermann University of Bremen, Germany
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Coetzee, M. 2000. What is it that matters most in the practice of nursing children? Curationis 23(3): 81- 85. Haegert, S. 2000. An African Ethic for Nursing. Nursing Ethics 7(6):492-502.
CONFERENCE PAPERS
Hill, R. 2000. More than surviving: Strategies for the caring progressive nurse manager. Nursing 2000: Providing Direction for the Future Nursing. An International Conference. Convened by the Forum for Professional Nurse Leaders of Private Health Care Facilities, Eskom Conference Centre, Midrand, Gauteng. Kyriacos, U. 2000. Teaching nursing research. 6th Annual Road to Research Day 2000, University of Cape Town, Faculty of Health Sciences. Mayers, P.M. 2000. Psychological Rehabilitation and Human Rights. Paper presented at the Psychological Rehabilitation conference, Cape Town. Mayers, P.M. 2000. Developing Mental Health Skills in Community Settings – Learning through Partnership. 6th Network for Psychiatric Nursing Research Conference, Oxford, UK. Mayers, P.M. 2000. Invited Theme Group convenor for Nurse Education Tomorrow International Conference, University of Durham, England. Mayers, P.M. 2000. The Lived Experience of Persons suffering from Chronic Fatigue Syndrome. Paper accepted for presentation to the International Qualitative Research Conference, Banff, Canada.
THESES AND DISSERTATIONS PASSED FOR HIGHER DEGREES
Coetzee, M. 2000. Learning to engage children: towards a model for undergraduate students in nursing – a grounded theory study. Ph.D. thesis, University of Cape Town. Doherty, T. 2000. Community health workers & professional nurses: A descriptive study of their relationship in two Western Cape communities. M.Sc. dissertation, University of Cape Town. Geogehan, M.D. 2000. A review of peri operative records used in hospitals in the Western Cape Metropolitan health region, comparison with international standards and recommendations for setting of local documentation standards. M.Sc. dissertation, University of Cape Town. Greathead, E.E. 2000. Competencies of first-line nurse managers in community health centres: A delphi study. M.Sc. dissertation, University of Cape Town. Michell, K. 2000. A quantitative and qualitative assessment of the knowledge and understanding professional nurses have of occupational hazards they are exposed to in the operating theatre. M.Sc. dissertation, University of Cape Town. Sheard, D. 2000. Enhancing the role of nurses in substance abuse intervention. A study of student nurses and nurse education institutions in the Western Cape. M.Sc. dissertation, University of Cape Town.
CONSULTANCY AND OTHER ACTIVITIES BASED ON EXPERTISE DEVELOPED RESEARCH
Staff in the department serve on numerous editorial boards and review panels of peer- reviewed journals. Thompson, R.A.E. A reviewer for the South African Medical Journal and member of the Editorial Advisory Board for South African Journal of Gerontology.
115
Thompson, R.A.E. Serves as a member of the panel of overseas advisers and reviewers for the Journal of Advanced Nursing, London. Clow, S. A member of the review panel and editorial board for Curationis – the South African nursing research journal. Clow, S. Currently assisting case managers (largely nurses) in the managed care sector. She has consulted both nationally and locally in working towards setting appropriate standards and a legislative framework for this new area of practice. Clow, S. Member of the committtee convening the establishment of an Active birth unit at Mowbray Maternity Hospital Clow, S. External examiner for the University of Natal’s MCur degree and MSocSc degree. Clow, S. External examiner for the University of Cape Town’s MPhil degree (Maternal and Child Health) Clow, S. International Council of Nurses ICN Code of Ethics for Nurses (revised 2000) ICN : Geneva 2000. (Professor SE Clow was one of seven members of the ICN expert panel for reviewing the International Code for Nurses. This has been adopted by the 129 member organisations and has been published.) Coetzee, M. & Mayers, P. Members of the review panel of Health SA Gesondheid. Coetzee, M. An external examiner for the University of Cape Town’s MPhil degree (Maternal and Child Health). Fouché, N. Critical Care Society of Southern Africa. Co-opted onto the Executive Council of the Critical Care Society to address the crisis of critical care nurse training & shortage. Hill, R.B. An external examiner for the University of the Witwatersrand MSc (Nursing) programme. Hill, R.B. An external examiner for the University of Namibia’s BA (Nursing) programme. Hill, R.B. An external examiner for the University of Stellenbosch’s BA (Nursing) programme. Hill, R.B. Acted as expert witness at inquests, concerning expectations of the ‘average nurse practitioner’, and more recently has been appointed Nurse Assessor assisting the Magistrate during inquests. Kyriacos, U. Appointed as consultant, lecturer and examiner to the South African Red Cross Society in respect of their new national programme for training in community-based care with an emphasis on the needs of HIV/AIDS sufferers. Mayers, P.M. Member of the Advisory Group for the Nursing Education Tomorrow conference, held annually in Durham, UK. Mayers, P.M. Member of the International Review panel for a new journal: Nurse Education in Practice, to be launched 2001. Mayers, P.M. Examiner for course work masters dissertation (Occupational Therapy), UCT, November 2000. Mayers, P.M. Acts as the South African link person for the National Network for Psychiatric Nursing Research group based in the UK. All staff are involved in curriculum review and transformation of Western Cape College of Nursing.
116
DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY
HEAD OF DEPARTMENT: Prof Z. M. van der Spuy
Postal Address: Department of Obstetrics and Gynaecology H Floor, Old Main Building, Groote Schuur Hospital Observatory 7925 South Africa Telephone: SA (21) 406-6112 Fax: SA (21) 448-6921 e-mail: [email protected]
DEPARTMENTAL PROFILE
During the year 2000, steady research progress took place in all subspecialty areas of Obstetrics and Gynaecology with an increased number of refereed publications appearing in print during the year.
The Oncology Unit had a particularly productive year with six refereed publications. Much of this work was associated with studies examining different methods of screening for cervical cancer. Professor Lyn Denny, who has been at the centre of this research, and her American collaborators have received considerable international recognition for the work carried out at Khayelitsha. This has resulted in ongoing external funding and many opportunities to speak as an invited speaker at a number of prestigious meetings including the FIGO meeting in Washington.
The Reproductive Medicine Unit published five papers. Two of these publications reflected the work of the Contraceptive Development Network to which the UCT Gynaecology Department is affiliated. This is a significant international link concerned with evaluating and developing contraceptive strategies in both developing and industrialised societies. This research is internationally funded and externally audited. The Cape Town unit has made a significant contribution to these studies and after the last cycle of audit was invited to continue as a key participant in these collaborative studies. The Reproductive Medicine Unit has also been engaged in ongoing clinical trials of the anti-progestogen trilostane. This work is unique and likely to have a significant impact on the management of labour including induction of labour in early pregnancy.
The Maternal and Fetal Medicine Unit also published five refereed papers during the year 2000. Two of these publications were in the area of critical care while Professor Ed Coetzee, together with Professor Dinky Levitt, published an authoritative review of diabetic management in Seminars in Neonatology. Members of the unit were privileged to attend and present work on homocysteine and apolipoprotein E at the biannual meeting of the International Society for Study of Hypertension in Pregnancy in Paris. Several projects were successfully concluded during 2000 and are currently in press. New collaborative links were also established with the Immunology unit at the University of Cape Town and there is every prospect of a productive year ahead.
During the year 2000, the Department has shown considerable strength in the extremely difficult area of clinical research. The Department, however, lacks adequate access to laboratory-based research medicine. It is hoped that the current Faculty initiatives designed to develop molecular biological sciences will bear fruit and that the opportunity to carry out meaningful laboratory research relevant to our own peculiar circumstances will soon become a reality. In the meantime, it should be recognised that the productivity of a clinical department is achieved only after a great deal of hard and often tedious work. It is therefore a tribute to the clinical staff of the Department that despite an enormous burden of clinical work and teaching, they still manage to find time to plan and execute high quality clinical research. 117
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG TERM HONORARY STAFF
CONTRACT STAFF
Professors 1 Honorary Professors 1 Emeritus Professors 2 Associate Professors (PAWC) 3 Senior Lecturers (PAWC) 7 Emeritus Associate Professors 2 Honorary Senior Lecturers 5 Lecturers (PAWC) 3 Honorary lecturers 2 Research Staff 13 TOTAL 12 Technical Support Staff 4 Administrative and Clerical staff 8 TOTAL 39
STUDENTS
Postdoctoral 1
Doctoral 2
Obstetrics and Gynaecology 28
Registrars
Undergraduates 467 TOTAL 498
RESEARCH FIELDS
Professor Zephne van der Spuy Contraceptive and interceptive development; reproductive failure; polycystic ovary syndrome; endocrine dysfunction; hormone replacement therapy Professor John Anthony Randomised controlled trial of nimodipine versus magnesium sulphate for the prevention of eclamptic seizures; Randomised controlled trial of low molecular weight heparin versus warfarin for the management of patients with posthetic heart valves; Study of ApoE genotype polymorphism and dyslipidaemia among women with pre-eclampsia; critical care management: ICU scoring systems; non-invasive methods of haemodynamic monitoring; Homocysteine metabolism in pre-eclamptic women and autonomic changes in pre-eclampsia compared to non- pregnant and normal pregnant controls Professor Mitch Besser HIV Professor Edward Coetzee Fetal ultrasound and diabetes; Prevention of mother-to-child transmission of HIV Dr Janet Cole Cervical cancer and HIV Dr Peter de Jong Gynaecological endoscopic surgery; urinary incontinence Dr George Draper Teaching methodology; Community obstetrics Professor Lynette Denny Cervical cancer screening; Rape protocol; Termination of pregnancy services Dr Silke Dyer Infertility and menopause Dr Susan Fawcus Maternal mortality; Abortion; Infections in pregnancy Dr Keith Gunston PMS; Rhesus disease; Health systems Dr Tham Matinde Decision delivery/interval in emergency caesarean sections Dr Arthur Nongauza Reproductive failure; Nutritional status in abruptio placentae Dr Leann Schoeman Management of rape victims; high risk obstetrics Dr Chantal Stewart Preterm labour; Pre-term premature membrane rupture, Ultrasound
118
EMERITUS PROFESSORS
Professor Dennis Davey Hormone replacement therapy and osteoporosis
DISTINGUISHED VISITORS
Dr Bridgette Byrne University College Hospital, Galway, Ireland; obstetric medicine Professor Wulf Utian HRT in the older woman Dr Marikje Alblas expert in the field of Fertility Regulation and Termination of Pregnancy; training in a variety of techniques for termination of pregnancy Dr Thomas Wright, Jr. Columbia University, New York Dr Louise Kuhn Columbia University, New York Professor Robert Shull Scott White Clinic, Temple, Texas, USA; genital prolapse Dr Michael O'Connell Hull Maternity Hospital, United Kingdom; amniotic fluid study Professor Paul Hilton Newcastle; presented at the Pelvic Floor Society Professor Tony Smith St Mary's Hospital, Manchester, United Kingdom; GP Refresher Course Guest Speaker; RCOG visiting lecturer Professor Michael de Swiet Queen Charlottes Hospital, United Kingdom; lectured on Lessons from the Maternal Mortality Enquiries Dr Markus Waloch Nkana Hospital, Kitwe, Zambia Dr Stephen Lindow University of Hull, United Kingdom; collaborative research; Clause 18 visitor; Refresher Course guest speaker Professor Sturla Eik-Nes National Center for Fetal Medicine, Department of Obstetrics and Gynaecology, University Hospital of Trondheim, Norway; lectured on the Detection of Fetal Anomalies, How, What and When Professor Richard Lilford University of Birmingham Dr Caroline Crowther Adelaide University for the Cochrane Colloquium Professor Jeffrey Nisker Coordinator Bioethics and London Health Sciences Centre, Ontario, Canada; Editor of Society of Obstetrics and Gynaecologists Journal
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Coetzee, E.J. & Levitt, N.S. 2000. Maternal diabetes and neonatal outcome. Seminars in Neonatalogy 5: 221-229. Davey, D.A. 2000. Androgens and Oestradiol - testosterone implants in the menopause. South African Journal of Obstetrics and Gynaecology 6(2): 24-28. Davey, D.A. 2000. HRT, Cancer and cardiovascular disease - second thoughts? South African Journal of Obstetrics and Gynaecology 6(3): 38-40. Denny, L., Kuhn, L., Pollack, A., Wainwright, H. & Wright, T.C. Jr. 2000. Evaluation of alternative methods of cervical cancer screening for resource-poor settings. American Cancer Society: 826- 833. Denny, L., Kuhn, L., Risi, L., Richart, R., Pollack, A., Lorincz, A., Kostecki, F. & Wright, T.C. 2000. Two stage cervical cancer screening: an alternative for resource-poor settings. American Journal of Obstetrics & Gynaecolology 183: 383-388. 119
Dyer, S.J. & Tregoning, S.K. 2000. Laparoscopic reconstructive tubal surgery in a tertiary referral centre - a review of 177 cases. South African Journal of Obstetrics and Gynaecology 6(3): 42- 47. South African Medical Journal 90(10): 1015-1019. Gilbert, W.M., Towner, D.R., Field, N.T. & Anthony, J. 2000. The safety and utility of pulmonary artery catheterisation in severe pre-eclampsia / eclampsia. American Journal of Obstetrics and Gynaecology 182: 1397-1403. Glazier, A.E., Anakwe, R., Everington, D., Martin, C.W., van der Spuy, Z., Cheng, L., Ho, P.C. & Anderson, R.A. 2000. Would women trust their partners to use a male pill? Human Reproduction 15(3): 646-649. Kuhn, L., Denny, L., Pollack, A., Lorincz, A., Richart, R. & Wright, T.C. 2000. Human Papillomavirus DNA testing for cervical cancer screening in low resource settings. Journal of National Cancer Institute 92(10): 818-825. Mariais, D.J., Rose, R.C., Lane, C., Kay, P., Nevin, J., Denny, L., Soeters, R., Dehaeck, C.M.C. & Williamson, A. 2000. Seroresponses to human papillomavirus types 16, 18, 31, 33 and 45 virus-like particles in South African women with cervical cancer and cervical intraepithelial neoplasia. Journal of Medical Virology 60: 403-410. Martin, C.W., Anderson, R.A., Cheng, L., Ho, P.C., van der Spuy, Z., Smith, K.B., Glasier, A.F., Everington, D. & Baird, D.T. 2000. Potential impact of hormonal male contraception: cross- cultural implications for development of novel preparations. Human Reproduction 15(3): 637- 645. Penny, J.A., Anthony, J., Shennan, A.H., de-Swiet, M. & Singer, M. 2000. A comparison of hemodynamic data derived by pulmonary artery flotation catheter and the esophageal Doppler monitor in pre-eclampsia. American Journal of Obstetrics and Gynaecology 183(3): 658-661. Smith, P., Anthony, J. & Johanson, R. 2000. Nifedipine in pregnancy. British Journal of Obstetrics and Gynaecology 107(3): 299-307. Tregoning, S.K., Ballard, R.C., Andersson, P-B., Fehler, H.G. & van der Spuy, Z.M. 2000. Antibodies to chlamydia trachomatis in patients presenting with ectopic pregnancy at Groote Schuur Hospital. South African Medical Journal 90(7): 727-730. Wright, T.C. Jr., Denny, L., Kuhn, L., Pollack, A. & Lorinez, A. 2000. HPV DNA Testing of self- collected vaginal samples compared with cytologic screening to detect cervical cancer. Journal of the American Medical Association 283(1): 81-86. Wright, T.C. Jr., Kuhn, L. & Denny, L. 2000. Human papillomavirus detection to screen for cervical cancer. American Journal of Obstetrics & Gynaecolology 284(1): 39-40. Young, P.F., Leighton, N.A., Jones, P.W., Anthony, J. & Johanson, R.B. 2000. Fluid management in severy pre-eclampsia (VESPA): Survey of members of ISSHP. Hypertensive Pregnancy 19(3): 249-259.
CHAPTERS IN BOOKS
Anthony, J. 2000. Hypertension in pregnancy. In Birkenhager, W.H., Reid, J.L. & Rubin, P.C. (eds) Eclampsia. Handbook of hypertension 21: 296-325. Amsterdam: Elsevier. James, M.F.M. & Anthony, J. 2000. Critical care management of the pregnant patient. In Birnbach, D.J., Gatt, S.P. & Datta, S. (eds) Textbook of Obstetric Anesthesia: 716-732. New York, London, Edinburgh, Philadelphia: Churchill Livingstone. Stewart, C.J.M. & Soothill, P.W. 2000. Testing placental function using oxygen transfer in utero. In Kinghorn, J., Jauniaux, E. & O'Brien, S. (eds) The Placenta: Basic Science and Clinical Practice: 275-284. RCOG Press.
PUBLISHED CONFERENCE PROCEEDINGS
De Jong, P. 2000. Complications in laparoscopic surgery and their prevention. Presymposium on laparoscopic and hysteroscopic surgery at Kenya Obstetrical and Gynaecological Society, Whitesands Hotel, Mombasa, Kenya, 1-3. De Jong, P. 2000. Hysteroscopic resection and ablation of the endometrium. Presymposium on laparoscopic and hysteroscopic surgery at Kenya Obstetrical and Gynaecological Society, Whitesands Hotel, Mombasa, Kenya.
CONFERENCE ABSTRACTS
Anthony, J. 2000. Anticoagulation in pregnancy. Invited Speaker, 1st Congress of the South African Heart Association, Stellenbosch, Book of Abstracts, 63. 120
Anthony, J. 2000. Antihypertensive drugs in pregnancy. Invited lecturer: Clinical Pharmacology Weekend, Cape Town. Anthony, J. 2000. Management of the critically ill hypertensive patient. Invited Speaker. Third Congress of the African society of Organization Gestosis and 32nd Congress of the Society for the Study of Pathophysiology of Pregnancy, Cape Town. Anthony, J., Burton, R., Owen, P. & Williams, M. 2000. Hyperhomosteinaemia is significantly more common amongst South African women with pre-eclampsia. 12th World Congress of the International Society for the Study of Hypertension in Pregnancy, Paris, 19(51): 92. Burton, R., Marais, D., Williams, M. & Anthony, J. 2000. Apolipoprotien E polymorphism and risk of pre-eclampsia in South Africa. Presented at 12th World Congress of the International Society for the Study of Hypertension in Pregnancy, Paris, 19(51): 87. Cheng, L., Hu, X., van der Spuy, Z., Heap, M., Mayo, A. & Glasier, A. 2000. The effect on contraceptive use of pregnancy rates (postpartum) of giving expert contraceptive conseling in the antenatal clinic. XVI FIGO World Congress of Gynaecology and Obstetrics, Washington D.C., Book of Abstracts, 56. FC1.22.03. Denny, L. 2000. The results of Cape Town visual screening trial. 18th International Papillomarirus Conference, Barcelona, 516: 692. Denny, L., Kuhn, L. & Wright, T.C. Jr. 2000. Prospects for cervical screening in developing countries. XVI FIGO World Congress of Gynaecology and Obstetrics, Washington D.C. Book of Abstracts, 9 ON3.03.03. Denny, L., Kuhn., Pollack, A. & Wright, T.C. 2000. HPV DNA testing as a primary screening test in low resource settings. 18th International Papillomavirus Conference, Barcelona, 503: 683. Marais, D.J., Best, J., Soeters, R., Denny, L., Dehaeck, C.M., Nevin, J., Rose, R.C., Kay, P. & Williamson, A- L. et al. 2000. Oral and cervical mucosal antibodies to human papillomavirus type 16 in women with cervical neoplasia. 18th International Papillomavirus Conference, Barcelona, 333: 413. Tregoning, S.K., Zinn, P.M. & van der Spuy, Z.M. 2000. Inhibition of progesterone secretion as an interceptive strategy. XVI FIGO World Congress of Gynaecology and Obstetrics, Washington D.C., Book of Abstracts, 15. FC1.01.07. Van der Spuy, Z.M. 2000. What is PCO? XVI FIGO World Congress of Gynaecology and Obstetrics, Washington D.C Book of Abstracts, 9 RM3.03.01. Wright, T.C., Denny, L., Kuhn, L. & Pollack, A. 2000. HPV DNA Testing of self-collected vaginal samples. 18th International Papillomarirus Conference, Barcelona, 94 034.
THESES AND DISSERTATIONS PASSED FOR HIGHER DEGREES
Denny, L. 2000. Evaluation of alternative strategies for prevention of cervical cancer in low resource settings: 1-177. Ph.D. thesis, University of Cape Town. Zinn, P. 2000. Trilostane as antiprogestin therapy in pregnancy termination: 1-114. M.Med. dissertation, University of Cape Town.
UNIVERSITY PUBLICATIONS AND WORKS OF A POPULAR NATURE
Alberts, P. 2000. Sheehan's syndrome. Obstetrics & Gynaecology Forum 10(2): 4. Anthony, J. 2000. Ultrasound and obstetric practice: Defining the limits. Specialist Medicine: 162-163. Burton, R. 2000. The management of idiopathic thrombocytopenic purpura (ITP) in pregnancy: an evidence based approach. Obstetrics and Gynaecology Forum 10(4): 8-15. Coetzee, E.J. 2000. To screen or not to screen: Detection of fetal anomalies in early pregnancy. Specialist Medicine: 64-170. De Jong, P. 2000. Letters to the Editor. Menopause Update 3(2): 6. De Jong, P. & Rienhardt, G. 2000. Innovation in the management of female urinary stress incontinence. Specialist Medicine: 172-179. De Jong, P. 2000. Complications of laparoscopy and how to avoid them. Specialist Medicine: 251-254. De Jong, P. 2000. Endometrial destruction for menstrual disorders - is it worth the effort? Special Medicine: 354-358. Puzey, M. 2000. An audit of mirena intra-uterine system in solo private practice over the last three years. Obstetrics and Gynaecology Forum 10(4): 4-6. Schoeman, L.K. 2000. Immunisation in pregnancy. Obstetrics and Gynaecology Forum 10(4): 16-22. Van Coeverden de Groot, H.A. 2000. Saving young mothers. Planned Parenthood Association of South Africa. Sexual & Reproduction Health Bulletin 9: 8-9.
121
Van der Spuy, Z.M. 2000. Cognitive function - the possible role of estrogen replacement therapy. Editorial. Obstetrics and Gynaecology Forum 10(4): 1-2.
UNPUBLISHED RESEARCH/TECHNICAL POLICY DOCUMENTS
Denny, L. & Martin, L. 2000. Policy for Management of Rape Survivors. Accepted by PAWC Health Department. Denny, L. & Martin, L. 2000. Protocol for management of survivors of sexual assault. Adopted by PAWC Health Department.
CREATIVE WORKS, PERFORMANCES, EXHIBITIONS
Denny, L. 2000. Khayelitsha cervical cancer screening projects "Silence of the wombs" directed by Athalie Crawford. 52 minute documentary on the experience of 3 women with diagnosis of cervical cancer designed for use by policymakers and health professionals. To be screened SABC 2001. Denny, L. 2000. Khayelitsha cervical cancer screening project "Nokhwezi's Story". 26 minute story designed to encourage women to go for Pap smears. To be screened SABC 2001.
CONSULTANCY AND OTHER ACTIVITIES BASED ON EXPERTISE DEVELOPED RESEARCH
Anthony, J. Committee member of the Faculty of the South African College of Obstetricians and Gynaecologists. Coetzee, E.J. Secretary of the Faculty of the South African College of Obstetricians and Gynaecologists. Coetzee, E.J. Chairman of the South African Society of Ultrasound in Obstetrics and Gynaecology. Coetzee, E.J. Member of the Council of South African of the South African Society of Obstetricians and Gynaecologists. Coetzee, E.J. Federal Councillor for the South African Medical Association. Denny, L. Chairperson, Board of Trustees, Rape Crisis, Cape Town since 1998, ongoing. Denny, L. Consultant to GF Jooste, Thutuxela Rape Centre, ongoing. Dyer, S. Chairman - South African Society of Medical Women. Dyer, S. Executive Committee Member of the South African Society of Reproductive Scientists and Surgeons. Van der Spuy, Z.M. Chairman - South African Representative Committee of Royal College of Obstetricians and Gynaecologists. Van der Spuy, Z.M. Committee member of the Faculty of the South African College of Obstetricians and Gynaecologists. Van der Spuy, Z.M. Committee member of the South African Society of Obstetricians and Gynaecologists. Van der Spuy, Z.M. Editorial Board of Gynaecology Forum. Van der Spuy, Z.M. Editor of Obstetrics and Gynaecology Forum. Van der Spuy, Z.M. Principal Investigator, Cape Town Branch of Contraceptive Development Network.
122
DEPARTMENT OF OCCUPATIONAL THERAPY
HEAD OF DEPARTMENT - Professor Ruth Watson
DEPARTMENTAL CONTACT DETAILS
Postal address: Department of Occupational Therapy Health Sciences Faculty Old Main Building Groote Schuur Hospital Observatory 7925 South Africa Telephone: SA (21) 406-6395 Fax: SA (21) 406-6324 e-mail: [email protected] web-page: http://www.uct.ac.za/depts/occther
DEPARTMENTAL PROFILE
The Department of Occupational Therapy aims to promote the health of individuals, groups and communities through their involvement in the occupations of life and the vehicle of a primary health care approach. Research is undertaken in the following areas: district-based rehabilitation; equal opportunities for disabled people (including entrepreneurship; children with special needs; productive behaviour of people with mental illness); student learning; values and ethics; and the occupations of particular groups (including women who live in poverty and the severely disabled).
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG TERM HONORARY STAFF CONTRACT STAFF Honorary Senior lecturer 1 Honorary lecturers 3 UNIVERSITY STAFF TOTAL 4 Associate Professors 1 Senior Lecturer 2 Lecturers 4 Admin & Clerical Staff 2 STUDENTS SUBTOTAL 9 PhD 1 Masters students 15 PAWC STAFF Undergraduate students 142 Senior Specialists /Senior lecturers 1 TOTAL 158 Lecturer 15 SUBTOTAL 16
TOTAL 25
RESEARCH FIELDS
PERMANENT STAFF
Associate Professor Ruth Watson Head of Department, qualitative research related to disability studies, health systems and community-based rehabilitation
123
Ms Madeleine Duncan Senior Lecturer, contemporary ethics, psychosocial rehabilitation of hospitalised persons who have mental illness Ms Lana van Niekerk Senior lecturer; participatory action research; community-based entrepreneurship development; writing for clinical reasoning; systems theory; psychiatric disability and work Ms Helen Buchanan Lecturer; writing for clinical reasoning; outcome-based practice and rehabilitation Ms Theresa Lorenzo Lecturer; disability issues; community-based entrepreneurship development; participatory action research; development of information systems for rehabilitation, gender issues
CONTRACT STAFF
Ms Elelwani Ramugondo (Development post) Lecturer, diversity in the learning context; developmental issues of children with HIV/AIDS; play and caregiver-child interaction with children living with HIV/AIDS and development of occupational therapy service at school clinics in the Western Cape Ms Roshan Galvaan (Development post) Lecturer; qualitative research; occupational storytelling; transitional occupations of domestic workers
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Fourie, M. 2000. A writer’s story: A narrative analysis of human occupation. The South African Journal of Occupational Therapy 30(2): 3-7.
CONFERENCE ABSTRACTS
Dawe, A. L. & Weskamp, K. 2000. The effect of biomechanical and activity analysis on the management of people with arthritis. Presented at the 6th Congress of the European Federation of Societies for Hand Therapy, Barcelona, Spain. De Jager, L. T. & Weskamp, K. 2000. Tendon transfer in a 3 year old child with tetraplegia. Poster presented at the 7th Congress of the European Societies for Surgery of the Hand, Barcelona, Spain. De Jager, L. T. & Weskamp, K. 2000. Tendon transfers in the hand of a child with tetraplegia. Presented at the 31st Congress of the South African Society for Surgery of the Hand, Durban, South Africa. Duncan, M.E. 2000. Vocational rehabilitation in forensic psychiatry: A tertiary hospital perspective. Presented at the Western Cape Psychosocial Rehabilitation Conference: Crossing Boundaries Towards Quality in Mental Health Care, Cape Town, South Africa. Furneaux, M., Percy, S., Roberts, C. & Seider, L. 2000. The influences on the experience of work of employees with mental illness in the open labour market: A collective case study. Presented at the South African Federation of Mental Health 2000 Conference: Towards Equal Employment for People with Mental Illness and Mental Handicap, Johannesburg, South Africa. Isaacs, R. 2000. Exit: Come and talk about your stay… Poster presented at the Western Cape Psychosocial Rehabilitation Conference: Crossing Boundaries Towards Quality in Mental Health Care, Cape Town, South Africa. Lorenzo, T., Mdlokolo, P., January, M. & Mguda, N. 2000. The Value of Ubuntu in social and economic transformation: A renewed hope through storytelling for disabled women in South Africa. Poster presented at two Conferences of Uppsala University, one on Disability and the other on Gender, Power and Culture, Uppsala, Sweden. Van Niekerk, L. & Lorenzo, T. 2000. Establishing indicators of outcome through the process of participatory action research. Presented at the First Qualitative Evidence-based practice conference, Coventry, United Kingdom. Watson, R.M. 2000. Learning how to help learners learn. Presented at the 6th Annual International Qualitative Health Research Conference, Banff, Canada. Weskamp, K. & Dawe, A. L. 2000. The importance of biomechanical and activity analysis in the treatment of arthritis: A case study. Presented at the 31st Congress of the South African Society for Surgery of the Hand, Durban, South Africa.
124
THESES AND DISSERTATIONS PASSED FOR HIGHER DEGREES
Beeton, H. 2000. Nature and meaning of occupation for young men with tetraplegia living on the Cape Flats: 1-115. M.Sc. dissertation, University of Cape Town. Bosch, J. 2000. Collaboration with aphasic clients toward autonomous occupational engagement: 1-115. M.Sc. dissertation, University of Cape Town. Galvaan, R. 2000. The live-in domestic worker’s experience of occupational engagement: 1-92. M.Sc. dissertation, University of Cape Town. Ramugondo, E. 2000. The experience of being an occupational therapy student with an underrepresented ethnic and cultural background: 1-98. M.Sc. dissertation, University of Cape Town.
UNPUBLISHED RESEARCH/TECHNICAL/POLICY DOCUMENTS
Armour, S., Kellard, G., Tapson, D., Williams, T. & Ramugondo, E. 2000. A descriptive study exploring the caregivers’ understanding of play, the attitudes they have towards play and the importance they attach to play for children with HIV/AIDS, at the Groote Schuur HIV/AIDS clinic. Department of Occupational Therapy, University of Cape Town. Brauer, T., Oates, C., Rubenstein, L., Stein, B. & Flieringa, H. 2000. The availability of mobility devices for physically disabled children attending special schools in the Western Cape. Department of Occupational Therapy, University of Cape Town. Brodrick, K. 2000. The individual, group and population interventions, with reference to the rehabilitation models i.e. biomedical, client-centred, community-based and independent living. (Assignment done in partial fulfilment of MSc degree in Occupational Therapy). Department of Occupational Therapy, UCT. Buchanan, H. 2000. Individual versus group versus population-based interventions. A critical analysis of rehabilitation in South Africa. Department of Occupational Therapy, University of Cape Town. Buchanan, H. 2000. The development of an activity centre for people with disabilities living in Hout Bay: A critique. Department of Occupational Therapy, University of Cape Town. Buchanan, H., Moore, R. & Van Niekerk, L. 2000. Assessing interactive journals: developmental portfolios. Cook, T., Smith, J., Woodford, L. & Buchanan, H. 2000. A pilot study to investigate the play of a specific group of children at Christine Revell Children’s Home. Department of Occupational Therapy, University of Cape Town. Emms, L., Gray, D., Johannsmeier, C., Schoeman, M. & Lorenzo, T. 2000. A qualitative research study exploring the role performance of disabled women living in the Khayelitsha area. Department of Occupational Therapy, University of Cape Town. Furneaux, M., Percy, S., Roberts, C., Seider, L. & Van Niekerk, L. 2000. The influences on the experience of work of employees with mental illness in the open labour market: A collective case study. Department of Occupational Therapy, University of Cape Town. Gifford, C., Horwits, J., Moodley, R. & Weskamp, K. 2000. The experience of meaningful occupations of elderly residents living at Neighbourhood Old Age Homes. Department of Occupational Therapy, University of Cape Town. Mdlokolo, P. 2000. Challenging disability through solidarity: Disabled womens’ experiences in Khayelitsha and Nyanga areas. Research report, Department of Occupational Therapy, University of Cape Town. Muller, S. 2000. The process of rehabilitation with particular attention to occupational therapy specific services and the African context. (Assignment done in partial fulfilment of MSc degreee in Occupational Therapy). Department of Occupational Therapy, UCT. Peffers, S., Schmitt, N., Stanbury, A., Tinsley, N. & Duncan, M. 2000. Substance use and leisure boredom of substance dependent adolescents. Department of Occupational Therapy, University of Cape Town. Sonnie, W. 2000. A critique of the foundation pillars of disability studies. (Assignment done in partial fulfilment of MSc degree in Occupational Therapy). Department of Occupational Therapy, UCT. Twigg, D., Venning, N., Vriend, I. & Galvaan, R. 2000. A study describing the Fountain House members’ perspective of the factors which influence independent employment seeking after the transitional employment programme at Fountain House (SA). Watson, R.M. & Lagerdien, KA. 2000. District Occupational Therapy Rehabilitation. Annual report to Health Systems Trust.
125
CONSULTANCY AND OTHER ACTIVITIES BASED ON EXPERTISE DEVELOPED IN RESEARCH
Lorenzo, T. 2000. The influence and response of religion in disability and rehabilitation programmes: Perspectives from experience with disabled women in South Africa. A seminar presented for the International Disability and rehabilitation Management course, Amsterdam, The Netherlands. Lorenzo, T. 2000. A consideration of disability issues and international disability: Programmes and policy. A seminar to Faculty of Theology, Uppsala University; Sweden.
126
DEPARTMENT OF OPHTHALMOLOGY
HEAD OF DEPARTMENT - Prof A D N Murray
DEPARTMENTAL CONTACT DETAILS
Postal address: Department of Ophthalmology UCT Medical School Observatory 7925 South Africa Telephone : SA (21) 406-6216/5 Fax : SA (21) 406-6218 email : [email protected]
DEPARTMENTAL PROFILE
The corneal clinic is investigating factors affecting the healing of corneal ulcers. The paediatric unit is involved in 3 projects: a trial comparing photoscreening devices used for the detection of strabismus and/or refractive errors, an ongoing study of retinopathy of prematurity in the current health care system, and a study collecting prospective and retrospective data on congenital cataract surgery with the "Helen Keller Worldwide" organisation. The retinal unit is involved in a multicentric randomized study evaluating the use of intravitreous hyaluronidase to clear vitreous haemorrhage.The strabismus unit is involved in four international multicentric projects: a prospective randomized trial of botulinum toxin in traumatic sixth nerve palsy, a prospective randomized clinical trial to assess whether very early surgery for infantile esotropia is beneficial, a prospective randomized study to determine whether pre-operative alternate occlusion improves binocularity and a study to determine the degree of binocular vision in patients with untreated infantile esotropia who are aligned as visual adults. The uveitis clinic is involved in a study assessing aqueous PCR levels in patients with luetic eye disease and a prospective trial to establish the role of intravitreal corticosteroids, in addition to antibiotics, for endophthalmitis.
These projects are in addition to seven local interdepartmental projects and twelve departmental projects.
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG TERM HONORARY STAFF CONTRACT STAFF Honorary Lecturers 1 TOTAL 1 Professors 1 Senior Lecturers 3 Lecturers 14 STUDENTS Research Staff 4 Masters 11 Administrative Staff 1 Undergraduate 160 TOTAL 23 TOTAL 171
RESEARCH FIELDS
PERMANENT STAFF (FULL -TIME)
Dr R Grotte Paediatric Consultant in Charge at Red Cross Childrens' Hospital; Paediatric Ophthalmology
127
Dr K A Lecuona Consultant Specialist; Groote Schuur Hospital; Lacrimal Drainage Disorders; Chloroquine Retinopathy; Audit of admission profiles in the Department of Ophthalmology; Glaucoma; Ocular Oncology Prof A Murray Professor and Head, Department of Ophthalmology, UCT Medical School and Groote Schuur Hospital; Strabismus Dr A Perrott Consultant specialist: Groote Schuur Hospital; Anterior Segment Surgery; Glaucoma
PERMANENT STAFF (PART-TIME)
Dr A Aleksic Anterior Segment Dr D Duval Retina Dr J C Hill Corneal Disease; Refractive Surgery Dr A Ivey Cataract ; Strabismus; Paediatric Ophthalmology Dr M Johnston Vitreo-Retinal Disease, Oculoplastics Dr F Kupper Anterior Segment Dr R Maske Ocular Allergy; Corneal disease, Anterior Segment Dr M Mesham Glaucoma; Refractive Surgery Dr B Phillips Anterior Segment Dr R Scholtz Vitreo-Retinal Disease Dr M S Solwa Glaucoma, Diabetes Dr P Steven Neuro-Ophthalmology Dr K Suttle Vitreo-Retinal Disease, Orbital Disease, Oculoplastics Dr C Willies Anterior Segment Surgery, Oculoplastics
DISTINGUISHED VISITORS
Dr Robert Doran Leeds Prof M Luntz New York Dr Bradley Black Louisiana, USA
RESEARCH OUTPUTS
PAPERS AND ARTICLES
Murray, A.D.N. 2000. Eye Muscles Surgery. Current Opinion in Ophthalmology 11: 336-341. Murray, A.D.N. 2000. Cataracts and Blindness. South African Medical Journal 90:1001-1002. Stannard, C.E., Sealy, G.R., Hering, E.R., Pereira, S.B., Knowles, R. & Hill, J.C. 2000. Malignant Melanoma of the Eyelid and Palpebral Conjunctiva Treated with Iodine-125 Brachytherapy. Ophthalmology 107: 951-958.
128
UNPUBLISHED RESEARCH / TECHNICAL / POLICY DOCUMENTS
Ivey, A. 2000. The role of systemic medication in the management of traumatic hyphaema. Department of Ophthalmology, University of Cape Town. Ivey, A. 2000. Tranexamic Acid versus Prednisone for the treatment of traumatic hyphaema. Department of Ophthalmology, University of Cape Town. Johnston, M. 2000. A safety and efficacy assessment of hyaluronidase solution injected into the vitreous body of the eye to hasten the clearing of blood from the vitreous. Department of Ophthalmology, University of Cape Town. Lecuona, K. 2000. The longterm follow up of patients on chloroquine therapy. Department of Ophthalmology, University of Cape Town. Lecuona, K. 2000. Admission profiles in the Department of Ophthalmology, University of Cape Town. Department of Ophthalmology, University of Cape Town. Murray, A.D.N. 2000. Isolated lacerations of extra-ocular muscles following penetrating stab wounds of the orbit. Department of Ophthalmology, University of Cape Town. Murray, A.D.N. 2000. Supermaximal surgical treatment of total sixth nerve paralysis. Department of Ophthalmology, University of Cape Town. Richards, J. 2000. Prospective, observational double blind controlled trial to establish the use of intravitreal corticosteroids, in addition to standard intravitreal antibiotics, for endophthalmitis. Department of Ophthalmology, University of Cape Town.
CONSULTANCY AND OTHER ACTIVITIES BASED ON EXPERTISE DEVELOPED IN RESEARCH
Professor Anthony Murray is Vice-President of the International Strabismological Association; Co- Chairman Sub-Saharan Africa Region, International Agency for the Prevention of Blindness; Member International Affairs Committee, American Association of Pediatric Ophthalmology and Strabismus and Board Member of the Pan Arab African Council of Ophthalmology. He serves as a member of the Department of Health's National Blindness Prevention Programme Committee and on the International Advisory Board of the Journal "Survey of Ophthalmology". He delivered the Angeline Park's Memorial Lecture in Washington in March 2000. He was elected to Chair IV of Academia Ophthalmologica Internationalis, the academic arm of the International Council of Ophthalmology, in May 2000. Dr. Rhian Grotte acts as a consultant on congenital cataract surgery to the Helen Keller Foundation.
129
DEPARTMENT OF ORTHOPAEDIC SURGERY
HEAD OF DEPARTMENT: Professor Johan Walters
DEPARTMENTAL CONTACT DETAILS
Postal address: Department of Orthopaedic Surgery H49 Old Main Building Groote Schuur Hospital Observatory 7925 South Africa Telephones: SA (21) 406-6157/8 Fax: SA (21) 447-2709 e-mail: [email protected]
DEPARTMENTAL PROFILE
The Department of Orthopaedic Surgery engaged in its first meaningful contract research project involving the use of recombinant Bone morphogenic protein in tibial fractures. We will look to promote our clinical strengths for future research purposes. Arthroplasty, Paediatric Orthopaedic Surgery and Trauma remain the most productive areas.
DEPARTMENTAL STATISTICS
PERMANENT AND CONTRACT STAFF STUDENTS Professor 1 Postgraduate FCS(SA) Orth & 17 Associate Professor 1 Mmed Senior Lecturers 3 Undergraduate MBChB 475 Senior Lecturers - Part-time 16 B.Sc Physio/Occupational 30 Lecturers – Full-time 2 Therapy 111 Research Staff 1 Diploma in Orthopaedic Nursing 26 Administrative and Clerical 3 Science Staff TOTAL 548 TOTAL 27
HONORARY STAFF Honorary Senior 3 Lecturers TOTAL 3
RESEARCH FIELDS
PERMANENT STAFF
Professor Johan Walters Head of Department; Knee Replacement after Osteotomy; Anterior Cruciate Bone Tunnel Study; Bone defects in Hip and Knee Replacement; Tibial Plateau Bone Graft in Knee Replacement, Patellectomy – An Outcome Study; Osteotomies around the knee: Long-term outcome study; a new Humeral Intramedullary Nail, a new Exoskeletal Fixation device; an Anatomical Study of Gluteus Minimus
130
Associate Professor EB Hoffman Head, Orthopaedic Service, Red Cross Children's Hospital; Rectus femoris transfer in diplegic cerebral palsy patients; Outcome of the management of simple bone cysts treated with steroid injection Dr C Maraspini Senior Lecturer, Groote Schuur Hospital; Fractures of the Distal Radius - ongoing review of functional results; Osteotomy for malunion of distal radial fractures; Fractures of the femoral neck in the elderly - a functional review; Fibular osteotomy for delayed union of the tibia Dr GM Siboto Senior Lecturer, Groote Schuur Hospital; A prospective study on Pelvic and Acetabular Fractures Dr MW Solomons Head, Martin Singer Hand Unit, Groote Schuur Hospital; Gluteus Minimus: Observations on its Insertion; Mechanics of External Fixation; Fracture Dislocations around the Elbow; Humerus Shaft Fractures; Distal Femur Fractures; Two-Stage Flexor Tendon Grafting Dr GP Grobler Part-time Lecturer, Princess Alice Orthopaedic Unit; 5 year results of the Duraloc Cup in THR; Long term results of bone grafting in revision hip surgery; Hip and knee pathology in 1st class rugby players after 10 years; Results of cementless THR; Beads vs hydroxy apatite Dr W de Jager Part-time Senior Lecturer, Hand Unit, Groote Schuur Hospital; Sports injuries of the Hand; Brachial plexus injuries Dr G du Toit Part-time Senior Lecturer, Princess Alice Orthopaedic Unit; A retrospective review of lumbar spinal fusions performed with various pedicular fixation devices to assess the efficacy of these devices in achieving a fusion; A continuing prospective study on the use of Segmental Spinal Correction System in the management of lumbar spinal pathology; A retrospective review of the efficacy of anterior transthoracic decompression of the spinal cord in paraplegia caused by progressive congenital non-dysrathic spinal deformities Dr P Makan Part-time Senior Lecturer, Groote Schuur Hospital; Prospective study to evaluate the “Cervical- U-Fixator” in Atlantoaxial fusions: Attempt at improving the clinical assessment of lumbar spinal stenosis with the use of the “Shuttle Walking Test” and by designing a new questionnaire - “The Oxford Claudication Score”; Respective review of the local experience with the use of the Spine Rectangle in instrumental spinal fusions; Basic science study assessing the effects of alcohol on bone in rats Dr AM Mullins Part-time Senior Lecturer, Princess Alice Orthopaedic Unit; Ankle Arthrodesis Dr BC Vrettos Part-time Senior Lecturer, Groote Schuur Hospital; Shoulder and trauma; A new Humeral Intramedullary Nail
CONTRACT RESEARCH STAFF
Mrs J Hearne Orthopaedic records
DISTINGUISHED VISITORS
Professor Charles Galasko Orthopaedic Surgeon, Department of Orthopaedic Surgery, University of Manchester, UK Mr Graham Keys Orthopaedic Surgeon, Macclesfield District General Hospital, UK Professor Ian Learmonth Orthopaedic Surgeon, University of Bristol, UK Professor Philippe Neyret Orthopaedic Surgeon, Hospital de la Croix-Rousse, Caluire, France Professor E H Simmons Orthopaedic Surgeon, Buffalo, USA Dr Thomas Thornhill Orthopaedic Surgeon, Brigham and Women’s Hospital, Boston, USA Dr Leo Whiteside Orthopaedic Surgeon, Bone & Joint Centre, St Louis, Missouri, USA 131
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Goldschmidt, R. 2000. The Challenge of Tuberculosis. Current Orthopaedics 14(1):18-25. Hoffman, E.B. & Magnus, K.G. 2000. Pyogenic Spondylitis and Early Tuberculous Spondylitis in Children: Differential Diagnosis with Standard Radiographs and Computed Tomography. Journal of Pediatric Orthopaedics 20:539-543. Skoll, P.J., Hudson, D.A., de Jager, W. & Singer, M. 2000. Long Term Results of Tendon Transfers for radial nerve palsy in patients with limited rehabilitation. ANN Plastic Surg. 45:122-126. Walters, J., St Clair Gibson, A., Lambert, M.I., Myburgh, K.H., Vaughan, C.L., O’Malley, M.J. & Noakes, T.D. 2000. The Relationship between Functional Capacity, Muscle Size and Strength in Chronic ACL Deficient and ACL Reconstructed Individuals. SA Journal of Physiotherapy 56: 3:12-18.
CONFERENCE ABSTRACTS
Burkhart, S., de Beer, J.F. & van Rooyen, K. 2000. Bone defects as a cause of failed arthroscopic bankart repairs. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. de Beer, J.F. & van Rooyen, K. 2000. The modified Latarjet procedure for shoulder instability with anterior glenoid deficiency. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. de Beer, J.F. & van Rooyen, K. 2000. The arthroscopic mumford procedure using two superior portals. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. de Beer, J.F. & van Rooyen, K. 2000. Pectoralis major transfer for irreparable tears of the subscapularis. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. de Beer, J.F., Boezaart, A.P. & van Rooyen, K. 2000. Arthroscopic Rotator Cuff Repair – a review of 96 cases. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. de Beer, J.F., Boezaart, A. & van Rooyen, K. 2000. Repair of Rotator Cuff Defects after calcium deposit removal. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. de Beer, J.F., Boezaart, A. & van Rooyen, K. 2000. Gleno-humeral joint injection. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. de Beer, J.F., Boezaart, A. & van Rooyen, K. 2000. Cryo-Arthroscopy – preliminary evaluation of a new concept. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. de Jager, W. 2000. Wrist Arthrodesis with Plate fixation. Presented at the Federation of the European Societies for Surgery of the Hand Congress, Barcelona, Spain. de Jager, W. 2000. Tendon transfer in a 3 year old child with Tetraplegia. Presented at the Federation of the European Societies for Surgery of the Hand Congress, Barcelona, Spain. de Jager, W. 2000. Tendon transfer in a 3 year old child with Tetraplegia. Presented at the SA Society for Surgery of the Hand Congress, Durban. de Jager, W. 2000. OA Thumb CMC joint – assessment and management options. Presented at the SA Society for Surgery of the Hand Refresher Course, Cape Town. du Toit, G. 2000. Selective Lumbar Fusion for Mechanical Low Back Pain in the presence of Multilevel Disc Degeneration: an Outcome Study. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. Erasmus, P.J. 2000. Kinematics of the Patello-Femoral Joint. Presented at the SA Orthopaedic Association Instructional Course, Cape Town. Erasmus, P.J. 2000. Tubercle Displacement Osteotomy – technique. Presented at the SA Orthopaedic Association Instructional Course, Cape Town. Erasmus, P.J. 2000. Technique of Distal Femoral Osteotomy. Presented at the SA Orthopaedic Association Instructional Course, Cape Town. Gajjar, V.P. & Makan, P. 2000. Spinal Biopsies: a review of comparing CT-Guided Needle, Image Intensifier- guided Needle and open Biopsies. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. Goldschmidt, R.B. 2000. Instability of the Hip in Cerebral Palsy. Presented at the SA Paediatric Orthopaedic Society Millennium Congress, Cape Town. Grobler, G. 2000. Perioperative Management. Presented at the SA Orthopaedic Association Instructional Course, Cape Town. Hastings, C.J. 2000. Overview: Pelvic Osteotomy. Presented at the SA Paediatric Orthopaedic Society Millennium Congress, Cape Town.
132
Hastings, C.J. 2000. AVN after Hip Infection. Presented at the SA Paediatric Orthopaedic Society Millennium Congress, Cape Town. Hastings, C.J. 2000. Transient Synovitis of the Hip. Presented at the SA Paediatric Orthopaedic Society Millennium Congress, Cape Town. Hastings, C.J. 2000. Mid and Forefoot Inuuries. Presented at the Smith & Nephew Skeletal Trauma Symposium, Kwa Maritane. Hastings, C.J. 2000. Subtrochanteric Fractures. Presented at the Smith & Nephew Skeletal Trauma Symposium, Kwa Maritane. Hoffman, E.B. 2000. Management of the unstable hip in mid lumbar myelomeningocele patients. Presented at the SA Paediatric Orthopaedic Society Millennium Congress, Cape Town. Hoffman, E.B. 2000. One stage management of developmental dysplasia in the older child. Presented at the SA Paediatric Orthopaedic Society Millennium Congress, Cape Town. Hoffman, E.B. 2000. Avascular necrosis and chondrolysis of the hip in children following slipped upper femoral epiphysis. Presented the SA Paediatric Orthopaedic Society Millennium Congress, Cape Town. Hoffman, E.B. 2000. Septic arthritis of the hip in children. Presented at the South African Orthopaedic Society Millennium Congresss, Cape Town. Hoffman, E.B. 2000. The management of Perthes disease. Presented at the South African Orthopaedic Society Millennium Congress, Cape Town. Hoffman, E.B. 2000. Tuberculosis of the hip in children. Presented at the South African Orthopaedic Society Millennium Congress, Cape Town. Hoffman, E.B. 2000. Tuberculosis of the knee in children. Presented at the South African Orthopaedic Society Millennium Congress, Cape Town. Hoffman, E.B. 2000. Discoid meniscus in children. Presented at the South African Orthopaedic Society Millennium Congress, Cape Town. Hoffman, E.B., Loots, S.B., Hastings, C.J. & Davies, J.Q. 2000. Physeal arrest following meningococcaemia. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. Hoffman, E.B., Munting, T.W. & Hastings, C.J. 2000. Transient Synovitis versus Septic Arthritis of the Hip. A clinical diagnosis? Presented at the 46th Congress of the SA Orthopaedic Association, Durban. Hoffman, E.B., Loots, S.B., Hastings, C.J. & Davies, J.Q. 2000. Physeal arrest following Meningococcaemia. Presented at the Institute of Child Health Research Day at Red Cross Children’s Hospital. Jaffe, R. 2000. RA: General principles of upper limb management. Presented at the SA Society for Surgery of the Hand Refresher Course, Cape Town. Loots, S.B., Davies, J.Q., Hastings, C.J. & Hoffman, E.B. 2000. Physeal arrest following Meningococcaemia. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. Makan, P. 2000. Classification of Spinal Instability. Presented at the SA Spine Society Congress, Cape Town. Makan, P. 2000. Gunshot Injuries to the Spine: when is surgery indicated? Presented at the Girdlestone Orthopaedic Society Meeting, Malta. Makan, P. 2000. Odontoid fractures: a review comparing Conservative Treatment, Posterior Atlanto- axial fusion and Anterior Dens Screw fixation. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. . Maraspini, C. 2000. New aspects of Bone Grafting. Presented at the Smith & Nephew Skeletal Trauma Conference, Flims, Switzerland. Maraspini, C. 2000. Fractures of the Distal Radius. Presented at the Smith & Nephew Skeletal Trauma Conference, Flims, Switzerland. Maraspini, C. 2000. Famoral Nailing: Antegrade or Retrograde. Presented at the Smith & Nephew Skeletal Trauma Conference, Flims, Switzerland. Maraspini, C. 2000. New aspects of Bone Grafting. Presented at the Smith & Nephew Skeletal Trauma Symposium, Kwa Maritane. Maraspini, C. 2000. Gunshot injuries of Bone and Joint. Presented at the Smith & Nephew Skeletal Trauma Symposium, Kwa Maritane. Maraspini, C. 2000. Femoral Shaft Fractures: Antegrade or Retrograde Nailing. Presented at the Smith & Nephew Skeletal Trauma Symposium, Kwa Maritane. Maraspini, C. 2000. Open Fractures of the Tibial Shaft: Management Options. Presented at the Smith & Nephew Skeletal Trauma Symposium, Kwa Maritane. Maraspini, C. 2000. Fractures of the Distal Radius. Presented at the Smith & Nephew Skeletal Trauma Symposium, Kwa Maritane. Maraspini, C. 2000. Fractures of the Distal Humerus. Presented at the Smith & Nephew Skeletal Trauma Symposium, Kwa Maritane.
133
Mullins, A.M. 2000. Ankle arthrodesis – the first choice. Presented at the SAFSA Symposium, Johannesburg. Munting, T.W., Hastings, C.J. & Hoffman, E.B. 2000. Transient Synovitis versus Septic Arthritis of the Hip. A clinical diagnosis? Presented at the 46th Congress of the SA Orthopaedic Association, Durban. Munting, T.W. & Vrettos, B.C. 2000. Missed Shoulder Dislocations. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. Newton, D.A. 2000. Traumatic Spinal Cord Injuries in Ankylosing Spondylitis. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. Roche, S.J.L. & Siboto, G.M. 2000. Pre-operative Indomethacin in Acetabular Fracture Surgery. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. Oleksak, M. & Makan, P. 2000. Traumatic Lumbar Spine Subluxations and Facet Dislocations. Presented at the SA Spine Society Congress, Cape Town. Oleksak, M. & Makan, P. 2000. Traumatic Lumbar Spine Subluxations and Facet Dislocations. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. Pollock, D. 2000. Patellectomy – technique. Presented at the SA Orthopaedic Association Instructional Course, Cape Town. Pollock, D. 2000. How to assess the clinical and radiological data to avoid complications: “What would you do with …” Presented at the SA Orthopaedic Association Instructional Course, Cape Town. Solomons, MW. Assessing the writs in RA. Presented at the SA Society for Surgery of the Hand Refresher Course, Cape Town. Solomans, M.W. 2000. Assessing the wrist in RA. Presented at the SA Society for Surgery of the Hand Refresher Course, Cape Town. Solomons, M.W. 2000. Two-Stage Flexor Tendon Grafting. Presented at the SA Society for Surgery of the Hand Refresher Course, Cape Town. Solomons, M.W. 2000. Humeral Shaft Fractures. Presented at the Smith & Nephew Skeletal Trauma Symposium, Kwa Maritane. Solomons, M.W. 2000. Fractures and Dislocations around the Elbow. Presented at the Smith & Nephew Skeletal Trauma Symposium, Kwa Maritane. Solomons, M.W. 2000. Distal Femoral Fractures. Presented at the Smith & Nephew Skeletal Trauma Symposium, Kwa Maritane. Sparks, L.T. 2000. Idiopathic Condrolysis of the Hip Joint. Presented at the SA Paediatric Orthopaedic Society Millennium Congress, Cape Town. Sparks, L.T. 2000. Triple Innominate Bone Osteotomy in Hip Dysplasia. Presented at the SA Paediatric Orthopaedic Society Millennium Congress, Cape Town. Sparks, L.T. 2000. Steel Osteotomy for Reidual Acetabular Dysplasia in the adolescent. Presented at the SA Paediatric Orthopaedic Society Millennium Congress, Cape Town. van Huyssteen, Hastings, C.J., Hoffman, E.B. & Roche, S.J.L. 2000. Late-onset Blount’s disease: an epidemiological, radiological and histological study. Presented at the 46th Congress of the SA Orthopaedic Association, Durban. Vrettos, B.C. 2000. Osteoporotic patient with a proximal Humerus Fracture. Presented at the 46th Congress of the SA Orthopaedic Assocation, Durban. Vrettos, B.C. 2000. The Elbow Joint in RA. Presented at the SA Society for Surgery of the Hand Refresher Course, Cape Town. Walters, J. 2000. Technique of Prox Tibial Osteotomy: Dome/Barrel-Vault. Presented at the SA Orthopaedic Association Instructional Course, Cape Town.
134
DEPARTMENT OF OTOLARYNGOLOGY
HEAD OF DEPARTMENT - Professor Sean Sellars
DEPARTMENTAL CONTACT DETAILS
Postal address: Department of Otolaryngology University of Cape Town Medical Faculty Anzio Rd Observatory 7925 South Africa Telephone: SA (21) 406-6420 Fax: SA (21) 448-6461 e-mail: [email protected]
DEPARTMENTAL PROFILE
The Department combines an academic hospital service with a university teaching, training and research commitment. It provides specialist clinical services to patients in the Western Cape and to those referred from other Provinces and teaches nursing staff in training and Primary Health care medical officers . Its University responsibilities include in-hospital and community based training of 160 5th year medical students, the teaching of dental and para-medical students, and the specialist training of both local graduates and graduates from other countries. A major outreach programme supplements the training of students and primary health care workers in the fundamentals of ear care. Clinical research and publication of research studies are encouraged at all levels.
DEPARTMENTAL STATISTICS
PERMANENT AND LONG TERM STUDENTS CONTRACT STAFF
Professors 1 Masters 11
Associate Professors 1 Undergraduate 160
Senior Lecturers 1 TOTAL 171
Lecturers 1 Clinical Research Fellows 3 Senior Lecturers (part-time) 7 Audiologists 2 Technical Staff (PAWC) 2 Administrative Staff 1 TOTAL 19
RESEARCH FIELDS
Banfield, G. Gunshot wounds of the neck; ear disease in state prisoners Chidziva, C. HIV disease in the head and neck Hassan, H. Al. Otologic disease in the urban and rural community Karjieker, A. Ototoxicity and tuberculosis
135
Fagan, J.J. Head and neck cancer; disection outcomes for malignancy Prescott, C.A.J. Undergraduate teaching and training; teaching and training of ENT in developing countries; ENT in primary care; acoustic rhinometry in children Sellars, S.L. Specialist training in South Africa; laryngeal disease; clinical outreach Thander, M.Z. Outcomes of choanal atresia surgery; ENT manifestation of HIV in children Vanlierde, M.R. Stroboscopy and voice pathology
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Fagan, J. & Myers, E.N. 2000. Laser ablation of granulation tissue at the tracheooesophageal fistula. Head and Neck 22(7):714-716. Mortimore, S. & Wormald, P.J. 1999. Management of acute complicated sinusitis: A 5-year review. American Academy of Otolaryngology-Head and Neck Surgery 121(5): 639-642. Prescott, C.A., Omoding, S.S., Fermor, J. & Ogilvy, D. 1999. International Journal of Pediatric Otorhinolaryngology. An evaluation of the ‘voice test’ as a method for assessing hearing in children with particular reference to the situation in developing countries 15;51(3):165-170. Robins, A.H. & Sellars, S.L. 2000. Oscar Wilde’s terminal illness: reappraisal after a century. The Lancet 356: 1841-1843. Thorp, M.A., Gardiner, I.B. & Prescott, C.A.J. 2000. Burow’s solution in the treatment of active mucosal chronic suppurative otitis media: determining an effective dilution. Journal of Laryngology and Otology 114: 432-436. Thorp, M.A., Isaacs, S. & Sellars, S.L. 2000. Tonsillectomy and tonsillitis in Cape Town – age and sex of patients. South African Journal of Surgery 38(3): 62-63.
136
DEPARTMENT OF PAEDIATRIC PATHOLOGY
HEAD OF DEPARTMENT: Associate Prof. Colin Sinclair-Smith
DEPARTMENTAL CONTACT DETAILS
Contact Details: Paediatric Pathology Institute of Child Health University of Cape Town Red Cross Children’s Hospital Klipfontein Road Rondebosch 7700 Telephone: SA (21) 658-5249/36 Fax: SA (21) 658-5485 or 689-1287 Email: [email protected]
DEPARTMENTAL PROFILE
The Department of Paediatric Pathology is predominantly a laboratory service department to Red Cross Children’s Hospital and to paediatric, neonatal and fetal services to other Western Cape Health Care Institutions. The pathology service functions as an amalgum of four sub units comprising: Anatomical Pathology, Chemical Pathology, Haematology and Medical Microbiology. Undergraduate teaching activities are largely undertaken through larger equivalent disciplines at Groote Schuur Hospital and the Medical School of the University of Cape Town to medical and physiotherapy students. Post-graduate teaching is undertaken to M.Phil (Paediatr Pathol), M.Med (in all the pathology disciplines), BSc (hons), MSc and PhD students at UCT as well as to M.Med students at Tygerberg Hospital. Research activities are almost entirely related to laboratory aspects of child health and is undertaken through projects driven by laboratory staff as well as collaborative support to clinical colleagues, mainly in paediatrics and paediatric surgery.
DEPARTMENTAL STATISTICS
PERMANENT AND LONG TERM STUDENTS CONTRACT STAFF Associate Professors 5 Doctoral 1 Senior Lecturers 2 Medical Registrars 2 Lecturers 2 Masters 9 Administrative and Clerical 1 TOTAL 12 Staff TOTAL 10
All academic staff are employed by the Provincial Administration of the Western Cape under conditions of service jointly agreed to by the Province and University of Cape Town.
RESEARCH FIELDS
Assoc. Prof. R.O.C. Kaschula Kaposi Sarcoma; EBV virus; Human Herpes Virus-8; Megacolon; Intestinal Pseudo- Obstruction; Muscular Dystrophy; Progenitors of Nephroblastoma; Childhood Castleman’s Disease
137
Assoc. Prof. C.C. Sinclair-Smith Hodgkin’s Disease; EBV Virus; Burkitt Lymphoma; Mitochondrial Myopathy; Hepatitis B Virus Glomerulonephritis Assoc. Prof. H.E. Henderson Lipids and Lipoproteins; Inborn Errors of Metabolism; Galactosaemia; Spinal Muscular Atrophy; Cystic Fibrosis; Metachromatic Leucodystrophy; Atherosclerosis Assoc. Prof. L.R. Purves PCR Diagnosis of Tuberculosis; Colonic Metabolism in Diarrhoea; Mass Spectrometric Applications in Paediatric Pathology Assoc. Prof. A.J. Lastovica Enteric Diseases; Campylobacter and Helicobacter Dr D.H. Hanslo Paediatric Infectious Diseases Dr M.H.G. Shuttleworth Immunophenotyping & Cytogenetics of Paediatric Leukaemia; Congenital Coagulation Disorders; Von Willebrand Multimers, Paediatric Myelodysplastic Syndromes Mr M.E. Engel Kaposi Sarcoma; Hodgkin’s Disease; Diagnostic Molecular Techniques; EBV; HHV-8; Burkitt Lymphoma Mrs F.M. Leisegang Molecular biology of HIV; Tuberculosis; Inborn Errors of Metabolism; Lipoprotein Lipase
RESEARCH OUTPUTS
RESEARCH PAPERS & REFEREED ARTICLES
Clee, S.M., Bissada, N., Miao, F., Miao, L., Marais, A.D., Henderson, H.E., Steures, P., McManus, J., McManus, B., Leboeuf, R.C., Kastelein, J.J. & Hayen, M.R. 2000. Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis. Journal of Lipid Research 41(4):521-3. Daubenton, J.D. & Sinclair-Smith, C.C. 2000. Severe Hypercalcemia in Association with a Juvenile Granulosa Cell Tumor of the Ovary. Medical and Paediatric Oncology 34:301-303. Engel, M., Essop, M.F., Close, P., Hartley, P., Pallesen, G. & Sinclair-Smith, C. 2000. Improved prognosis of Epstein-Barr virus associated childhood Hodgkin's lymphoma: study of 47 South African cases. Journal of Clinical Pathology 53: 182-186. Karylshev, A.V., Linton, D., Gregson, N.A., Lastovica, A.J. & Wren, B.W. 2000. Identification of high molecular weight lipopolysaccharide of C. jejuni as type II capsular polysaccharide: genetic and biochemical evidence. Molecular Microbiology 35: 529-541. Pienaar, S., Eley, B., Beatty, D. & Henderson, H.E. 2000. X-linked agammaglobulinaemia and the underlying genetics in two kindreds. Journal of Paediatrics and Child Health 36: 453-456. Wassenaar, T.M., Lastovica, A.J., Duim, B., Wagenaar, J.A., Coloe, P.J. & Fry, B.N. 2000. Genetic characterization of Campylobacter jejuni O:41 isolates in relation with Guillain-Barré syndrome. Journal of Clinical Microbiology 38: 874-876. Westwood, A.T.R., Eley, B.S., Gilbert, R.D. & Hanslo, D. 2000. Bacterial infection in children with HIV: a prospective study from Cape Town, South Africa. Annals of Tropical Paediatrics 20: 193-198. Zar, H.J., Dechaboon, A., Hanslo, D., Apolles, P., Magnus, K.G. & Hussey, G. 2000. Pneumocystis carinii pneumonia in South African children infected with Human Immunodeficiency Virus. Pediatric Infectious Disease Journal 19: 603 – 607. Zar, H.J., Tannenbaum, E., Apolles, P., Roux, P., Hanslo, D. & Hussey, G. 2000. Sputum induction for the diagnosis of pulmonary tuberculosis in infants and young children in an urban setting in South Africa. Archives of Disease in Childhood 82:305-308.
CHAPTERS IN BOOKS
Lastovica, A.J. & Skirrow, M.B. 2000. Clinical Significance of Campylobacter and Related Species other than C. jejuni. In Nachamkin, I. & Blaser, M. (eds) Campylobacter: 89-120. Washington DC: M. American Society for Microbiology.
RESEARCH LETTER
Lastovica, A.J. & Le Roux, E. 2000. Efficient isolation of campylobacteria from stools. Journal of Clinical Microbiology 38:2798-2799.
138
PUBLISHED CONFERENCE PROCEEDINGS
Engel, M.E. & Lastovica, A.J. 2000. Epidemiological and clinical profiles of Campylobacter infection in South African Children in 1996-1998. Proceedings of 69th Annual Meeting of the Society for Applied Microbiology - Glasgow, United Kingdom. Supplement to Journal of Applied Microbiology, 2000, 89 (1).xiv.
CONFERENCE ABSTRACTS
Kaschula, R.O.C. 2000. Osseus Ewing’s Sarcomas seen at Red Cross Children’s Hospital over 35 years. Federation of SA Societies of Pathology, Warmbaths, South Africa. Kaschula, R.O.C. 2000. Intestinal Dysmotality childhood. Association of Pathologists from East, Central and Southern Africa, Victoria Falls, Zimbabwe. Kaschula, R.O.C. 2000. Human herpesvirus-8 in kaposi sarcoma patients of Africa: Does it play a role? Assoc. of Pathologists from East Central & Southern Africa, Victoria Falls, Zimbabwe. Struwe, F.G. & Kaschula, R.O.C. 2000. Rhinosporidiosis as seen in Cape Town, South Africa. Paediatric Pathology Society, Edinburgh, UK. Kaschula, R.O.C. 2000. Childhood peripheral primitive neuroectodermal tumours in Cape Town. Paediatric Pathology Society. Edinburgh, UK. Kaschula, R.O.C. 2000. An analysis of 32 PNET/Ewing’s sarcoma cases from Red Cross Children’s Hospital, Cape Town, South Africa. XXIII International Congress of International Academy of Pathology. Nagoya, Japan. Struwe, F.G., Davies, J.Q., Andronikou, S., Fieggen, A.G. & Kaschula, R.O.C. 2000. Clinical pathological findings in 3 cases of hemimegalencephaly. University of Cape Town, Institute of Child Health Annual Research Day, Cape Town. Lastovica, A.J. & Engel, M.E. 2000. Campylobacter concisus: pathogen or commensal? Results of a five-year study of paediatric patients in South Africa. 100th Annual American Society for Microbiology meeting in Los Angeles, CA. Lastovica, A.J. & Engel, M.E. 2000. The epidemiology of other Campylobacter species. WHO Consultation on the Increasing Incidence of Campylobacteriosis in humans, Copenhagen, Denmark. Henderson, H.E., Leisegang, F. & Reynolds, L. 2000. DNA analysis of spinal musculature in the Western Cape. South African Society of Clinical Biochemists, Federation of the South African Society of Pathologists (FSASP) congress, Warmbaths. Clee, S.M., Bissada, N., Miao, F., Miao, L., Marais, A.D., Henderson, H.E., Steures, P., McManus, J., McManus, B., Leboeuf, R.C., Kastelein, J.J. & Hayden, M.R. 2000. Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis. Lipid and Atherosclerosis Society of Southern Africa (LASSA) Congress, Durban. Henderson, H., Leisegang, F., Hayden, M. & Marais, A.D. 2000. Lipoprotein lipase gene defects are common in pregnancy-induced hypertriglyceridemic pancreatitis. Lipid and Atherosclerosis Society of Southern Africa (LASSA) Congress, Durban. Engel, M.E. & Lastovica, A.J. 2000. Epidemiological and clinical profiles of campylobacter infection in South African children in 1996-1998. 69th Annual Meeting of the Society for Applied Microbiology in Glasgow, UK.
CONSULTANCY AND OTHER ACTIVITIES BASED ON EXPERTISE DEVELOPED IN RESEARCH
Lastovica, A.J. Nominated to the Editorial Board of the Journal of Clinical Microbiology. Lastovica, A.J. Invited to be an international scientific advisor to assist in the organization of the 11th International Workshop on Campylobacter, Helicobacter and related organisms, to be held in Freiberg, Germany, Sept, 2001. Lastovica, A.J. Invited to attend a workshop: Strategic planning health related water research: microbiological programme, held under the aegis of the Water Research Commission, Pretoria, March 27, 2000. Lastovica, A.J. Participation in the steering committee of Water Research Commission project No. K/1(150): Occurrence of emerging viral, bacterial and parasitic pathogens in source and treated water in South Africa. A meeting was held in Pretoria on March 28, 2000. Lastovica, A.J. Participation in the Water Research Commission committee on Microbiological protocols for research involving source and treated water. A meeting was held in Pretoria on May 12, 2000.
139
Lastovica, A.J. & a UWC colleague, Dr Pieter Gouws. Organized a Seminar: Campylobacter 2000 which was held on Aug 19, 2000 The concept is for provision of an open forum of research on Campylobacter that is currently in progress. This one-day Seminar was highly successful, with about 35 delegates participating. Kaschula, R.O.C. Forensic Autopsy Report to Sydney Harbour Police, Sydney, Australia to resolve interpretation of malicious malnutrition of a child, based upon publications. Kaschula, R.O.C. Report to Royal Liverpool Children’s Inquiry in respect to retention of autopsy tissues at United Kingdom Children’s Hospitals.
140
DEPARTMENT OF PAEDIATRIC SURGERY
HEAD OF DEPARTMENT: Professor H. Rode
DEPARTMENTAL CONTACT DETAILS
Postal Address: Department of Paediatric Surgery Institute of Child Health Red Cross War Memorial Children’s Hospital Rondebosch 7700 South Africa Telephone: SA (21) 658-5012 Fax: SA (21) 685-6632 e-mail: [email protected]
DEPARTMENTAL PROFILE
The department is one of four accredited training centres for career paediatric surgeons and recognised as such by the College of Medicine of South Africa and the Interim South African Medical and Dental Council. The department serves as a regional and referral hospital and is regarded as a national centre in terms of organ transplantation and specialised neurosurgical and cardiothoracic surgical procedures. In addition the department has under its auspices the only dedicated trauma centre for children as well as the Child Accident Prevention Foundation of Southern Africa. An extensive surgical outreach programme was developed to improve the surgical care of children. In the last 21 years more than 38 South African and foreign postgraduate students trained as career paediatric surgeons in the department. Surgery. Outreach programmes for higher surgical training has been established with 3 Sub-Saharan and West African countries. Research is being conducted in the department in liver transplantation, burn therapy and common diseases of Africa. Financial support is received from the MRC, Pharmaceutical companies and private donations.
DEPARTMENTAL STATISTICS
PERMANENT AND LONG TERM STUDENTS
CONTRACT STAFF
Professor 1 Doctoral 1
Associate Professor 1 Masters 3 Senior Lecturers 3 TOTAL 4 Research Staff 3 Administrative Staff 3 Honorary Senior Lecturer 1 TOTAL 12
RESEARCH FIELDS
PERMANENT STAFF
Professor H Rode Head of the department; Burn and Nutrition Research; congenital abnormalities; oncology and vascular supply to pelvic structures Associate Professor A.J.W. Millar Organ transplantation; gastro-enterology; oncology and endoscopic surgery
141
Dr RA Brown Gastro-enterology; endoscopic surgery; constipation and gastro-intestinal polyposis Dr AB van As Traumatology, congenital abnormalities and gastro-intestinal diseases R Albertyn Research social worker; Paediatric Pain and rehabilitation J Raad Principle medical technologist; Manometry and gastro-enterology N du Toit Research Social Worker; Child Accident Prevention P de Wet Control Medical Technologist; Thermal injury, antiseptics
RESEARCH OUTPUTS
RESEARCH PAPERS AND ARTICLES
Bickler, S.W. & Rode, H. 2000. Priorities for Paediatric Surgery in Africa. Africa Health: 5-9. Botha, J., Spearman, W. & Millar, A.J.W. et al. 2000. 10 Years of Liver Transplantation at Groote Schuur Hospital. South African Medical Journal 90(9): 880-883. Goddard, E.A., Spearman, C.W.N., McCulloch, M.J., Millar, A.J.W. & Kahn, D. 2000. Cytomegalovirus (CMV) infection in paediatric liver transplant recipients in a developing country. Pediatric Transplant 4(2): 48. Jandera, V., Hudson, D.A., de Wet, P.M., Innes, P.M. & Rode, H. 2000. Cooling the Burn Wound: Evaluation of Different Modalities. Burns 26: 265 – 270. McCulloch, M., Gilbert, R., Eley, B., Zulke, L., McCurdie, F., Pascoe, M., Pontin, A., Millar, A.J.W. & Kahn, D. 2000. Overview of paediatric renal transplant programme in a developing country. Pediatric Transplant 4(2):103. Millar, A.J.W., Spearman, W., McCulloch, M., Goddard, L., Rode, H. & Kahn, D. 2000. Paediatric transplantation in a developing country – taking stock. Pediatriac Transplant 4(2): 129. Spearman, C.W.N., McCulloch, M.J., Goddard, E., Millar, A.J.W., Hartley, P. & Kahn, D. 2000. Post- transplant lymphoproliferative disease (PLTD) in paediatric liver transplant recipients in a developing country. Pediatric Transplant 49(2): 53.
CHAPTERS IN BOOKS
Millar, A.J.W., Rode, H. & Cywes, S. 2000. Intestinal Atresia and Stenosis. In Ashcraft, K.W. (ed.) Paediatric Surgery, Third Edition: 406 – 424. Philadelphia: W.B. Saunders Co Ltd. Rode, H., Brown, R.A. & Cywes, S. 2000. Degenerative Hollow Visceral Myopathy mimicking Hirshsprung’s Disease. In Holschneider, A.M. & Puri, P. (eds) Hirschsprung’s disease and allied disorders 2nd edition: 197-210. Netherlands: Harwood Academic Publishers. Brown, R.A. & Cywes, S. 2000. Disorders and Congenital Malformations Associated with Hirshsprung’s Disease. In Holschneider, A.M. & Puri, P. (eds) Hirschsprung’s disease and allied disorders 2nd edition: 137-145. Netherlands: Harwood Academic Publishers.
LETTERS
Rode, H. 2000. Surgical Wound Infections with Reference to Children. Specialist Medicine XXII (5): 271. Rode, H. 2000. Editorial. Wound Care and Burns. Specialist Medicine XXII (5): 271.
142
DEPARTMENT OF PAEDIATRICS & CHILD HEALTH
HEAD OF DEPARTMENT: Professor DJ Power
DEPARTMENTAL CONTACT DETAILS Postal address: Department of Paediatrics & Child Health Red Cross Children's Hospital Rondebosch 7700 Cape Town South Africa Telephone: SA (21) 658-5324 Fax: SA (21) 689-1287 Email: [email protected]
DEPARTMENTAL PROFILE
Research in the fields of paediatrics and child health is carried out under the umbrella of the Institute of Child Health (ICH), is inter-disciplinary and reflects the clinical problems of the wider community. Research focused on infectious diseases, nutrition, immune deficiencies, some organ specific diseases, health systems and health policy for children. This activity is reflected in the Department's annual Research Meeting at which 36 oral and 27 poster presentations were given over two days. The highlights of this years research have included collaboration with overseas researchers in the fields of tuberculosis and HIV/AIDS at both a clinical and basic science level. This collaboration and the initial results have enabled researchers to obtain major external funding with which to extend overseas collaboration and attract both local and foreign doctoral students to work in our laboratories.
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG TERM CONTRACT STUDENTS STAFF Professors 4 Doctoral 8 Emeritus Professors 2 Masters 51 Associate Professors 12 Undergraduate 305 Emeritus Assoc Professors 4 TOTAL 364 Senior lecturers (full time) 10 Senior lecturers (part time) 9 Lecturers (full time) 16 Lecturers (part time) 18 Honorary Senior Lecturers (full time) 5 Honorary lecturers (part time) 3 Research Staff (including Senior 39 Research Officer, Research Officers, Scientific Officer) Administrative and clerical 7 TOTAL 129
143
RESEARCH FIELDS
PERMANENT STAFF
Professor DJ Power Head Department of Paediatrics; ambulatory and primary care services Professor D W Beatty Head of Immunology; inherited and acquired immunodeficiencies; infectious diseases Professor M E Jacobs Head Child Health Unit; community paediatrics, child health policy Professor F Bonnici endocrinology; growth hormone; diabetes; human insulin analogues Associate Professor G D Hussey Infectious diseases; tuberculosis; vitamin A; HIV infections; haemophilus influenza vaccines Associate Professor P S Hartley Senior Lecturer; haematology; oncology Associate Professor J D Ireland Senior Lecturer; gastroenterlogy; liver disease; cystic fibrosis Associate Professor C D Karabus haematology; oncology Associate Professor M Klein pulmonology; critical care Associate Professor M D Mann nuclear medicine; diarrhoeal disease Associate Professor AA Sive Senior Lecturer; nutrition; gastroenterology Associate Professor J Daubenton Senior Lecturer, oncology Associate Professor E G Weinberg allergy; asthma Associate Professor C Motala Senior Lecturer; allergy Associate Professor D L Woods neonatology; perinatal health education Dr A Allie Senior Lecturer; general paediatrics Dr A Argent Senior Lecturer; critical care Dr J D Burgess Senior Lecturer; HIV infections Dr S V Delport Senior Lecturer; endocrinology; diabetes Dr L D Henley Senior Lecturer; medical ethics; medical social science Dr G H Moller Senior Lecturer; neonatology Dr A Philotheou Senior Lecturer; diabetes; endocrinology Dr LG von B Reynolds Senior Lecturer; pulmonology; muscle disorders, critical care Dr P Roux Senior Lecturer; oncology; bone marrow transplants, HIV Dr G H Swingler Senior Lecturer; ambulatory paediatrics; primary health care Dr C Adnams Senior Lecturer; developmental medicine Dr M Hann Senior Lecturer; neonatology Dr ATR Westwood Senior Lecturer; cystic fibrosis, gastroenterology; ambulatory paediatrics Dr M Hendricks Senior Lecturer; nutrition
144
Dr M McCulloch Senior Lecturer; takayasu's arteritis; infant dialysis; renal and liver transplantations Dr F Desai Lecturer; oncology; haematology Dr B Eley Lecturer; immunology; infectious diseases Dr D Greenfield Lecturer; community neonatology Dr J Lawrenson Lecturer; cardiology Dr L Linley Lecturer; community neonatology Dr JE Mostert Lecturer; ambulatory paediatrics Dr H M Power Lecturer; health informatics Dr J Stirling Lecturer; cardiology Dr C Thompson Lecturer; neurodevelopment; neonates Dr I Els Lecturer, neonatology Dr M Hatherill Lecturer, cardiology Dr G Riordan Lecturer, neurology; epilepsy Dr SM Kroon Lecturer, community neonatology
CONTRACT RESEARCH STAFF
Dr S Anderson T.B.-Immunology; genetics Dr H Zar pulmonology; HIV
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Botha, J.F., Spearman, C.W., Millar, A.J., Michell, L., Gordon, P., Kahn, D., Lopez, D., Butt, A., Thomas, J., McCulloch, M., James, M., Kirsch, R.E. & Terblanche, J. 2000. Ten years of Liver Transplantation at Groote Schuur Hospital. South African Medical Journal 90:880-883. Coppin, B., Dennis, N. & Turner, C.A. 2000. Clinical, cytogenetic and molecular study of 47 females with r(X) chromosomes. Ann. Hum Genet 64: 277-293. Daubenton, J.D. & Sinclair-Smith, C. 2000. Severe hypercalcaemia in association with a juvenile granulosa cell tumor of the ovary. Medical Pediatric Oncology 34: 301-303. Engel, M., Essop, M.F., Close, P., Hartley, P.S., Pallesen, G. & Sinclair-Smith, C. 2000. Improved prognosis of EBV associated childhood Hodgkin's lymphoma study of 47 South African cases. Journal of Clinical Pathology 53:182-186. Goddard, E., Mouton, S., Westwood, A.R.T. & Ireland, J.D. 2000. Cryptosporidial sclerosing cholangitis in an apparently immunocompetent child. Journal of Paediatric Gastroenterology and Nutrition 31(3): 317-320. Hanekom, W.A., Yogev, R., Heald, L.M., Edwards, K.M., Hussey, G.D. & Chadwick, E.G. 2000. Effect of vitamin A therapy on serologic responses and viral load changes after influenza vaccination in children infected with the human immunodeficiency virus. Journal of Pediatrics 136:550-552. Hatherill, M., McIntyre, A.G., Wattie, M. & Murdoch, I.A. 2000. Early hyperlactataemia in critically ill children. Intensive Care Medicine 26:314-318. Hatherill, M., Sykes, K., McIntyre, A.G. & Murdoch, I.A. 2000. Procalcitonin may help differentiate disseminated herpes simplex viral infection from bacterial sepsis in neonates. European Journal Pediatrics 159:168-169.
145
Hatherill, M., Tibby, S.M., Turner, C., Ratnavel, N. & Murdoch, I.A. 2000. Procalcitonin and cytokine levels: relationship to organ failure and mortality in pediatric septic shock. Critical Care Medicine 28:2591-2594. Hendricks, M.K., Perez, E.M., Roberts, M. & Weight, M. 2000. A prospective study of the growth of children attending the Bishop Lavis Malnutrition Clinic. South African Journal of Epidemiological Infections 15: 32-35. Henley, L.D. & Landman, W.A. 2000. Legalising advance directives in South Africa. South African Medical Journal 90(8): 785-787. Henley, L.D. & Landman, W.A. 2000. Implementing children's constitutional health care rights fairly. South African Medical Journal 90(6): 601-604. Hussey, G., Apolles, P., Arendse, Z., Yeates, J., Robertson, A., Swingler, G. & Zar, H.J. 2000. Respiratory syncytial virus infections in children with lower respiratory tract infection. South African Medical Journal 90:509-512. Landman, W.A. & Henley, L.D. 2000. Rationing and children's constitutional health-care rights. South African Journal of Philosophy 19(1): 41-51. Levitt, N.S., Lambert, E.V., Woods, D., Hales, C.N., Andrew, R. & Seckl, J.R. 2000. Impaired glucose tolerance and elevated blood pressure in low birth weight, nonobese young South African adults: early programming of cortisol axis. Journal of Clinical Endocrinology and Metabolism 85: 4611- 4618. Motala, C., Kling, S., Gie, R., Potter, P.C., Manjra, A., Vermeulen, J., Weinberg, E.G. & Green, R. 2000. Guideline for the management of chronic asthma in children- 2000 update. South African Medical Journal 90(5): 524-539. Nurse, B., Puterman, A.S., Haus, M., Berman, D. & Weinberg, E.G. 2000. PBMCs from both atopic asthmatic and nonatopic children show a TH2 cytokien response to house dust mite allergen. Journal of Allergy & Clinical Immunology 106(1)1: 84–91. Pienaar, S., Eley, B., Beatty, D.W. & Henderson, H.E. 2000. X-linked agammaglobulinaemia and the underlying genetics in two kindreds. Journal Paediatric Child Health 36(5):453-456. Rubinstein, R., Karabus, C.D., Smuts, J., Kolia, F. & Van Rensburg, E.J. 2000. Prevalence of human parvovirus B19 and TT virus in a group of young haemophiliacs in South Africa. Haemophilia 6: 93 – 97. Roux, P., Henley, L.E. & Cotton, M. 2000. Burden and cost of in-patient care for HIV-positive paediatric patients. Status in the Cape Town metrople during the second week of March 1999. South African Medical Journal 90:1008-1011. Roux, P. & Novitzky, N. 2000. The Cape Town experience of haematopoetic stem cell transplantation: The paediatric programme. South African Medical Journal 90: 804-811. Swingler, G.H. & Hussey, G.D. & Zwarenstein, M. 2000. Duration of illness in ambulatory children diagnosed with bronchiolitis. Arch Pediatric Adolesc Med 154:997-1000. Swingler, G.H. & Zwarenstein, M. 2000. An effective trial of a diagnostic test in a busy outpatients department in a developing country:issues around allocation concealment and envelope randomization. Journal of Clinical Epidemiology 53:702-706. Swingler, G.H. & Zwarenstein, M. 2000. Telephone follow-up in a randomized controlled trial in a less developed country: feasibility, validity and representativeness. Journal of Clinical Epidemiology 53:331-334. Swingler, G.H. 2000. Chest radiography in ambulatory children with acute lower respiratory infections: effective tuberculosis case finding? Annals Tropical Paediatrics 20:11-15. Swingler, G.H. 2000. The radiologic differentiation between bacterial and viral lower respiratory infection in children: a systematic literature review. Clinical Pediatrics 39:627-633. Te W Naude, J., Donald, P., Hussey, G., Kibel, M., Louw, A., Perkins, D. & Schaaf, S. 2000. Twice weekly vs. daily chemotherapy for childhood tuberculosis. Pediatric Infectious Disease Journal 19:405-410. Thorburn, K., Hatherill, M., Roberts, P.C., Durward, A., Tibby, S.M. & Murdoch, I.A. 2000. Evaluation of the 5-French saline paediatric gastric tonometer. Neonatal and Paediatric Intensive Care 2: 973-980. Tibby, S.M., Hatherill, M. & Murdoch, I.A. 2000. Use of transesophageal doppler ultrasonography in ventilated pediatric patients: derivation of cardiac output. Critical Care Medicine 28:2045-2050. Weinberg, E.G. 2000. Urbanization and childhood asthma: An African perspective. Journal of Allergy & Clinical Immunology 105(2)1: 224-231. Weinberg, E.G. & Naya, I. 2000. Treatment preferences of adolescent patients with asthma. Pediatric Allergy Immunology 11:49-55. Westwood, A.R.T. & Ireland, J.D. 2000. Children with cystic fibrosis in South Africa: An inproving nutritional picture. Journal of Tropical Paediatrics 46: 119-121.
146
Westwood, A.T.R., Eley, B.S., Gilbert, R.D. & Hanslo, D. 2000. Bacterial infections in children with HIV: a prospective study from Cape Town, South Africa. Annals Tropical Paediatrics 20: 193- 198. Woods, D.L. 2000. A distance learning programme in maternal and newborn care. Perinatology 2: 283- 285. Woods, D.L. 2000. A self-directed learning course for midwives to improve the care of pregnant women and their newborn infants with HIV infection in South Africa. Nursing Update 24: 4. Woods, D.L. 2000. A distance learning course for midwives to improve the care of pregnant women and their newborn infants with HIV/AIDS. Bulletin AIDS 2000, 9: 9. Woods, D.L. A distance learning course for midwives to improve the care of pregnant women and their newborn infants with HIV/AIDS. HST Update 2000, 51: 20. Zar, H.J. & Bateman, E. 2000. Near fatal asthma - a review. South African Journal Critical Care Medicine 16:5-9. Zar, H.J., Brown, G., Donson, H., Brathwaite, N., Mann, M.D. & Weinberg, E.G. 2000. Spacers made from sealed cold-drink bottles were as effective as conventional spacers in children with acute asthma. Evidence-Based Medicine 5:79. Zar, H.J., Dechaboon, A., Hanslo, D., Apolles, P., Magnus, K. & Hussey, G. 2000. Pneumocystis carinii pneumonia (PCP) in HIV-infected children in South Africa. Pediatric Infectious Disease Journal 19:603-607. Zar, H.J., Maartens, G., Wood, R. & Hussey, G. 2000. Pneumocystis carinii pneumonia (PCP) in HIV infected patients in Africa: an important pathogen? South African Medical Journal 90:684-688. Zar, H.J., Mann, M.D. & Weinberg, E.G. 2000. Overlooking of Cochrane reviews in asthma research. Lancet 355:70. Zar, H.J., Tannenbaum, E., Apolles, P., Roux, P., Hanslo, D. & Hussey, G. 2000. Sputum induction for the diagnosis of pulmonary tuberculosis in infants and young children in an urban setting in South Africa. Arch Dis Child 82: 305-308. Zar, H.J., Weinberg, E.G., Binns, H.J., Gallie, F. & Mann, M.D. 2000. Lung deposition of aerosol - a comparison of different spacers. Archives of Disease in Childhood 82:495-498.
Non-peer reviewed Beatty, D. & Eley, B. 2000. Plomary Immunodeficiency Disease in Cape Town. Allergy and Clinical Immunology International 267-287. Berman, D. 2000. Pollinosis and the aerobiology of Southern Africa. Allergy and Clinical Immunology International 258-261. Daubenton, J.D. & Hartley, P.S. 2000. Special Report Cancer Treatment in Children. Transactions: Journal of the Colleges of Medicine of South Africa 44 (1): 29-30. Fransman, D., McCulloch, M., Lavies, D. & Hussey, G. 2000. Doctors' attitudes to the care of children with HIV in South Africa. AIDS Care 12:89-96. Harrison, D., Harker, H., Heese, HdeV. & Mann, M. 2000. The accuracy of anthropometric measurements for the road-to-health card. Nursing update 5:12. Ireland, J.D. 2000. People, Pollution, Pets and Parasites. Vital News Third Quarter 24 - 25. Ireland, J.D. 2000. Much More Than A Mere Worm: Modern Medicine of SA November/December: 44 – 51. Ireland, J.D. 2000. The Mighty Worm. Journal of Modern Pharmacy April: 38 -43. Ireland, J.D. 2000. The Ways of Worms. Journal of Modern Pharmacy August: 44 - 48. McKenzie, R.H. & Roux, P. 2000. Disseminated BCG after bone marrow transplantation in child with SCID. Pediatric Dermatol 17:208-212. Motala, C. 2000. Management of Chronic asthma in children. Journal of Continuing Education for General Practitioners. Update: August: 66-70. Motala, C. 2000. Food allergy-Current Issues. Current Allergy & Clinical Immunology 13(4). Motala, C. 2000. Editorial: Allergy and the Environment. Current Allergy & Clinical Immunology 13(4). Reynolds, L. 2000. The rights of the child: a challenge for health professionals. HST Update May 52:3-4. Health Systems Trust. Swingler, G. 2000. Heavy breathing and the diagnosis of pneumonia. Paediatric Chronicle, June. Weinberg, E.G. 2000. Allergy to bee stings: A bee sting in an allergic patient could be fatal - assistance is provided to prevent this eventuality. CME August 18(8): 662 – 668. Weinberg, E.G. 2000. The effects of urbanization and other factors on childhood asthma in South Africa. Allergy and Clinical Immunology International, 262-266.
BOOKS Sarkin, J. & Proudlock, P. 2000. Law of South Africa. Public Health Chapter (revision). Butterworths. 147
Seear, M., Hendricks, M. & Bamford, L. 2000. The child who is failing to grow. In Seear, M. (ed.) Manual of Tropical Paediatrics: 25-50. Cambridge: Cambridge University Press. Woods, D.L. (ed.) 2000. Perinatale MIV/VIGS. Handleiding III. Perinatal Education Programme. University of Cape Town Printers. Woods, D. & Malan, A. 2000. Notes on the Newborn Infant (6th edition). University of Cape Town Printers. Fifth Edition.
PUBLISHED CONFERENCE PROCEEDINGS & CONFERENCE ABSTACTS
Adnams, C.M., Kodituwakku, P.W., Hay, A., Kitching, A., May, P.A. & Viljoen, D. 2000. Neuropsychological Characteristics of South African Children with Fetal Alcohol Syndrome. Research Society on Alcoholism 23rd Annual Scientific Meeting, Denver, USA. Adnams, C.M., Kodituwakku, P.W., Hay, A., Kitching, A.E., Adams, R., Viljoen, D. & May, P.A. 2000. Deficient Skills in Executive Control Functioning in Children with Fetal Alcohol Syndrome and Possible Interventions. 9th International Conference for Treatment of Addictive Behaviours, Somerset West, South Africa. Adnams, C.M., Kodituwakku, P.W., Hay, A., Kitching, A., May, P.A., Viljoen, D. 2000. Neuropsychological Characteristics of South African Children with Fetal Alcohol Syndrome. Research Society on Alcoholism 23rd Annual Scientific Meeting, Denver, USA. Andronikou, S., Kader, E. & McCulloch, M. 2000. Imaging in the new millenium, CSIR Conference Centre, Pretoria. Imaging Strategy for African Children with first diagnosed UT1 in Tertiary Hospital Setting. Andronikou, S., Kader, E. & McCulloch, M. 2000. Imaging Strategy for African Children with first diagnosed UTI in Tertiary Hospital Setting. Paediatric Radiology 30:B32. Andronikou, S., Kader, E. & McCulloch, M. 2000. Imaging Strategy for African Children with first diagnosed UT1 in Tertiary Hospital Setting. Pediatric Radiology 30:B32. Andronikou, S., McCulloch, M. & Goddard, E. 2000. The Angiographic Features of 21 South African children with Takayasu's Aortitis (non-specific aortoarteritis). Paediatric Radiology 30:B26. Bateman, E.D., Poyser, M., Zar, H.J. & Parnell, S. 2000. Correlation between near-fatal and fatal asthma attacks and socio-economic deprivation in Cape Town, South Africa. European Respiratory Journal 16 (Suppl 31):368s. Daubenton, J.D., Hartley, P.S., Desai, F. & Karabus, C.D. 2000. Paraplegia/Paraparesis in Children with Cancer. Proceedings of the 4th Continental meeting of International Society of Paediatric Oncology in Africa, Sun City, South Africa. (Abstract), 96. Daubenton, J.D., Hartley, P.S., Desai, F. & Karabus, C.D. 2000. Paraplegia/Paraparesis in children with cancer. 4th Continental Meeting of SIOP in Africa. De Decker, H.P. 2000. The CATCH phenotype: from diversity to a single gene theory. Presented at the first congress of The South African Heart Association. Desai, F., Hartley, P.S., Daubenton, J.D. & Karabus, C.D. 2000. Intrarenal Neuroblastoma. Proceedings of the 4th Continental meeting of International Society of Paediatric Oncology in Africa, Sun City, South Africa, 90. (Abstract). Desai, F., Hartley, P.S., Daubenton, J.D. & Karabus, C.D. 2000. Intrarenal neuroblastoma. 4th Continental Meeting of SIOP in Africa. Etiebet, M., Fransman, D., Coetzee, N., Forsyth, B., Fawcuss, S. & Hussey, G. 2000. Pregnant women opt for participation in district based interventions to reduce perinantal transmission. AIDS2000 Conference, Durban. Giese, S. 2000. Drafting the New Child Care Act. Children and Violence Forum. Giese, S. 2000. Establishing a directory of services for children and youth infected / affected by HIV/AIDS. Presentation to National AIDS and Children Task Team (NACTT). Giese, S. 2000. Social assistance for children made vulnerable by HIV/AIDS. CHAiN workshop. Giese, S. 2000. Social assistance for children made vulnerable by HIV/AIDS. Written submission to the National Committee of Inquiry into a Comprehensive Social Security System. Giese, S. 2000. Social assistance for children made vulnerable by HIV/AIDS. Oral submission to the Inter-departmental Committee of Inquiry into a Comprehensive Social Security System. Giese, S. 2000. The South African Law Commission's provisional recommendations for children living with HIV/AIDS. Public Meeting to launch CHAiN. Giese, S. 2000. Commentary on the SALC's Consultative Paper: Children living with HIV/AIDS. Submission to the SALC. Goddard, E., Spear-man, C.W.N., McCulloch, M., Millar, A.J.W. & Kahn, D. 2000. Cytomegalovirus (CMV) infection in paediatric liver transplant recipients in a developing country. Paediatric Transplantation 4(Supp 2): 48.
148
Goeiman, H., Hendricks, M., Russia, M. & Bourne, L. 2000. An Integrated Approach to Malnutrition in Childhood: experiences from Bloekombos, Western Cape Province. From Lab to Land Nutrition Congress 2000, International Convention Centre, Durban. (abstract South African Journal of Clinical Nutrition 13 (3): 113). Guthrie, T. 2000. Children with Disabilities: The Care Dependency Grant. Seminar on Social Security in South Africa. Guthrie, T. 2000. Problems with the Existing Social Security System for Children Infected and Affected by HIV/AIDS. CHAiN workshop. Guthrie, T. 2000. Social Assistance for Children Affected by HIV/AIDS - SALC Discussion Document. Workshop discussing the SALC's review of the Child Care Act. Guthrie, T. 2000. The Care Dependency Grant - Limitations and Possibilities. Social Security Workshop. Guthrie, T. 2000. The Financial Implications of Social Assistance for Children Affected by HIV/AIDS. WC workshop on the Challenges of Children Affected by HIV/AIDS. Guthrie, T. 2000. The Right of Children with Disabilities to Social Security: Budgetary Concerns. The Disabled Children's Budget Workshop. IDASA. Guthrie, T., Giese, S. & Footner, L. 2000. Issue Paper on Social Security for Children in South Africa. Submission made to the Inter-departmental Committee of Inquiry into a Comprehensive Social Security System. Guthrie, T. & Proudlock, P. 2000. Tobacco Products Control regulations. Submission to the Dept of Health. Guthrie, T., ShungKing, M., Mathambo, V., Abrahams, E., Proudlock, P. & Giese, S. 2000. Policy Guidelines for Youth and Adolescent Health. Submission to MCWH, DOH. CHPI. Guthrie, T. 2000. Social Assistance for Children with Disabilities and HIV/AIDS: the Possibilities of the Care Dependency Grant. Oral & written submission made to thte Inter-departmental Committee of Inquiry into a Comprehensive Social Security System. Hann, M. 2000. Low Birthweight Baby Care in the New Millenium. 7th World IAMANEH Conference, Stellenbosch, South Africa. Hann, M. & Horn, A. 2000. Feeding regimens and the prevention of Necrotising Enterocolitis. 7th World IAMANEH Conference, Stellenbosch, South Africa. Hartley, P.S., Desai, F., Daubenton, J.D. & Karabus, C.D. 2000. Hepatitis B outbreak in a Paediatric Oncology Unit. Proceedings of the 4th Continental meeting of International Society of Paediatric Oncology in Africa, Sun City, South Africa. (Abstract), 79. Hartley, P.S., Desai, F., Daubenton, J.D. & Karabus, C.D. 2000. Hepatitis B outbreak in a Paediatric Oncology Unit. 4th Continental Meeting of SIOP in Africa. Hartley, P.S., Karabus, C.D., Werner, I., Hesseling, P.B., Wessels, G. & Stones, D.K. 2000. Incidence of childhood cancer in the Eastern, Western and Northern Cape Provinces of South Africa. International Society of Paediatric Oncology, XXXII Meeting 35(3): 243. Amsterdam, The Netherlands. Hendricks, M., Kibel, M., Rohde, J. & Desai, F. 2000. “Machie-bytes": a training programme for child health care workers. Ottawa in Africa, 9th International Ottawa Conference on Medical Education, Cape Town. Hendricks, M., le Roux, M. & Fernandes, M. 2000. An assessment of the Protein Energy Malnutrition Scheme in the Northern Cape Province of South Africa. From Lab to Land Nutrition Congress 2000, International Convention Centre, Durban. (abstract SAJCN 13 (3): 112). Hendricks, M., Saitowitz, R., Shung King, M., Irlam, J., Hussey, G., Ernstzen, K., Scloss, I., Reay, G. & Huskisson, J. 2000. Vitamin A deficiency: a brochure for primary health care workers. Ottawa in Africa, 9th International Ottawa Conference on Medical Education, Cape Town. Hendricks, M., Small, J., Irlam, J., Shung King, M., Linley, L. & Jacobs, M. 2000. The case narrative as a method of problem-based learning in a maternal and child health distance education programme, Ottawa in Africa, 9th International Ottawa Conference on Medical Education, Cape Town. Hewitson, J.P. 2000. Minithoracotomy for atrial septal defect closure: an alternative to device closure for the developing world. (Presented at the first congress of the South African Heart Association - Stellenbosch). Horn, A., Woods, D.L., Thompson, C. & Els, E. 2000. The safety, efficacy and practicality of a method of head cooling in infants with hypoxic ischaemic encephalopathy. Research Day. Institute of Child Health, University of Cape Town. Hussey, G. 2000. HIV infection and the Child. 7th World IAMANEH conference, Stellenbosch, South Africa. Hussey, G. 2000. Interaction between HIV and vitamin A. International Workshop on long-term food based approaches to eliminating vitamin A deficiency in Africa. Newlands, South Africa. 149
Hussey, G. 2000. CG vaccine. United Action Against TB Conference, Cape Town. Hussey, G. 2000. Critique on Vitamin A and HIV infection. World Health Organsiation. consultation on vitamin A. Yverdon-les-Bains, Switzerland. Hussey, G. 2000. Fever in HIV Infection. UCT Paediatric Refresher Course, Cape Town. Hussey, G. 2000. BCG vaccine controversies. Annual Brewelskloof TB symposium, Worcester. Hussey, G. 2000. Reducing mother-to-chuild transmission of HIV. CHAiN Conference, Cape Town Irlam J. 2000. Presentation to the 7th World IAMANEH (International Association for Maternal and Neonatal Health) conference, Stellenbosch, "MCH News: Four Years On". Irlam, J. 2000. Presentation to the 9th International Ottawa Conference on Medical Education, Cape Town. "Experiences with the Use of Infomation and Communication Technology (ICT) in a Distance Learning Programme". Khann, K., Fischer, S., Colarinha, P., Gordon, I., Mann, M., Piepsz, A., Olivier, P., Sixt, R. & van Velzen, J. 2000. Guidelines for bone scintigraphy in children. http://www.eanm.org/glines/gl_bone_en.html. European Annual Nuclear Medicine. McCulloch, M., Andronikou, S., Hoffman, E.B., Goddard, E. & Kahn, D. 2000. Avascular necrosis of the hip in paediatric renal transplant recipients. Paediatric Transplantation 4(Supp 2): 122. McCulloch, M., Eley, B., Zuhlke, L., Sinclair, P., Reynolds, L. & Argent, A. 2000. Peritoneal Dialysis as a form of Continuous Renal Replacement Therapy for Infants less than 5kg in a Developing Country. Pediatric Nephrology 14:C136. McCulloch, M., Eley, B., Zuhlke, L., Sinclair, P., Reynolds, L. & Argent, A. 2000. Peritoneal Dialysis as a form of Continuos renal Replacement Therapy for Infants less than 5kg in a Developing Country. First International Conference on Pediatric Continuous Renal Replacement Therapy, Orlando, Florida, USA Pediatric Nephrology 14: C136. McCulloch, M., Eley, B., Zuhlke, L., Sinclair, P., Reynolds, L. & Argent, A. 2000. Peritoneal Dialysis as a form of Continuous Renal Replacement Therapy for Infants less than 5kg in a Developing Country. South African Renal Society and the Renal care Society of South Africa, Lord Charles Hotel, Somerset West, Cape Town. McCulloch, M., Gilbert, R., Eley, B., Zuhlke, L., McCurdie, F., Pascoe, M., Millar, A. & Kahn, D. 2000. Overview of paediatric renal transplant programme in a developing country. Paediatric Transplantation Supp2: 103. McCulloch, M., Gilbert, R., Eley, B., Zuhlke, L., McCurdie, F., Pascoe, M., Pontin, A., Millar, A. & Kahn, D. 2000. Overview of paediatric renal transplant programme in a developing country.First Congress of the International Pediatric Transplant Association - Venice). Paediatric Transplantation 4(Supp 2): lO3. McCulloch, M., Gilbert, R., Eley, B., Zuhlke, L., McCurdie, F., Pascoe, M., Pontin, A., Millar, A. & Kahn, D. 2000. Overview of paediatric renal transplant programme in a developing country. South African Renal Society and the Renal care Society of South Africa, Lord Charles Hotel, Somerset West, Cape Town. McCulloch, M., Goddard, E., Andronikou, S., Mandelstam, S. & Lawrenson, J. 2000. A Review of Takayasu'sArteritis at Red Cross Children's Hospital from 1978 to 2000. Surgical Research Society, Cape Town. McCulloch, M. & Goddard, E. 2000. European Society of Pediatric Radiology, 37th annual congress, Lisbon, Portugal. Andronikou, S. 2000. The Angiographic Features of 21 South African childrenwith Takayasu's Aortitis(non-specific aortoarteritis). Pediatric Radiology 30:B26. Michael, J., Abbott, M., Sinclair, P. & McCulloch, M. 2000. Practicalities of Paediatric Peritoneal Dialysis, South African Renal Society and the Renal care Society of South Africa, Lord Charles Hotel, Somerset West, Cape Town. Millar, A.J.W., Hartley, P.S., Khan, D., Rode, H., Spearman, W. & Cywes, S. 2000. Extended hepatic resection with graft in waiting for inoperable liver tumor. Millar, A.J.W., Spearman, W., McCulloch, M., Goddard, E., Rode, H. & Kahn, D. 2000. Paediatric liver transplantation in a developing country - taking stock. Paediatric Transplanation 4(Supp2): 129. Motala, C. 2000. Allergy & Clinical Immunology International Sydney Australia 2000 12(5). Motala, C. 2000. New guideline for the management of childhood asthma in South Africa. Specialist Medicine XXII(10): 612-618. Perez, E., Hendricks, M., Alexander, R., Iloni, K., Nel, E., Venter, M., Mare, W. & Sheik-Ismael, A. 2000. The role of a stimulation programme in the recovery of severely malnourished children. From Lab to Land Nutrition Congress 2000, International Convention Centre, Durban. abstract South African Journal of Clinical Nutrition 13 (3): 122. Power, M., Bischoff, R. & Fosseus, K. 2000. A paper-based "problem-knowledge coupler" is possible. HISA 2000, Bloemfontein.
150
Power, M., Eccles, M., Fosseus, K., Grimshaw, J., Heathfield, H., Kay, S. & Roux, P. 2000. Making medical informatics work in a developing country. MMIW 2000 Conference, Manchester. Power, M. 2000. HIS implementation: Experience in the Western Cape. (Invited lecture) HISA 2000, Bloemfontein. Power, M. 2000. Personal health information in the computer age. (Keynote lecture) HISA 2000, Bloemfontein. Proudlock, P. 2000. The draft Firearms Control Bill and how to write a submission to Parliament. Workshop for children's rights organisations, youth groups and NGO's. Proudlock, P. 2000. The draft National Health Bill. Children and Violence Forum. Proudlock, P. & Shung-King, M. 2000. Firearms Control Bill: Oral presentation of submission before Portfolio Committee on Safety and Security. Proudlock, P. 2000. Firearms Control Bill. Submission to Parliament. Proudlock, P. 2000. Firearms Control Bill. Submission to Secretariat on Safety and Security. Schloss, I., Huskisson, J., Reay, G., Charlton, K., Saitowitz, R., Hendricks, M., Shung King, M., Hussey, G., Irlam, J. & Ernstzen, K. 2000. Vitamin A Brochure improves knowledge of Primary Health Care Workers. From Lab to Land Nutrition Congress 2000, International Convention Centre, Durban, August 2000. abstract South African Journal of Clinical Nutrition 13 (3): 126. Shung-King, M. 2000. The impact of Tobacco on child health. Millipaed Conference (South African Association of Paediatricians). Shung-King, M., Proudlock, P. & Adnams, C. 2000. Foetal Alcohol Syndrome. Co-ordinated and facilitated presentation to the Portfolio Committee on Health. Shung-King, M., Proudlock, P. & Guthrie, T. 2000. Children on Philippi farms. Site tour for national and provincial parliamentarians, local government and community organisations. Shung-King, M. & Proudlock, P. 2000. Paediatricians, Policy and Parliament. Millipead National Conference (South African Association of Paediatricians). Sinclair, P. & McCulloch, M. 2000. A Review of the use of intravenous Methylprednisolone/ Mendozaregime in Childhood prednisone resistant nephrotic syndrome at Red Cross Children's Hospital Surgical Research Society 2000, Cape Town. Sinclair, P., McCulloch, M., Maythem, D., Goddard, E., Eley, B., Van Dugteren, G., Morrison, C. & Wiggelinkhuizen, J. 2000. Audit of Paediatric Renal Biopsies at Red Cross Children's Hospital, CapeTown. Surgical Research Society 2000, Cape Town. Slater, C., Kibel, M., Rohde, J., Olivier, L. & Hendricks, M. 2000. Multi-media programmes for child health care workers and students. Ottawa in Africa, 9th International Ottawa Conference on medical education, Cape Town. Small, J., Hendricks, M., & Irlam, J. 2000. Lessons from a distance education post-graduate programme. Ottawa in Africa, 9th International Ottawa Conference on medical education, Cape Town. Small, J. 2000. Recognition of Prior Learning (RPL) - an indicator of a life-long learning institution. International Conference on Lifelong Learning, Higher Education and Active Citizenship, Cape Town. Small, J. 2000. Recognition of Prior Learning for community based nurses. RPL Challenges Higher Education and Workplace Practice Conference, Eskom Centre, Johannesburg. Spearman, C.W., McCulloch, M., Goddard, E., Millar, A.J., Hartley, P. & Kahn, D. 2000. Post- transplant lymphoprolerative disease (PTLD) in paediatric liver transplant recipients in a developing country. Paediatric Transplantation 4(Supp.2): 53. Swingler, G. 2000. Weighing the evidence using systematic reviews; the potential of systematic reviews to capture all evidence from completed traditional medicine studies (invited speaker). Presented at the International Symposium on Traditional Medicine: Better science, policy and services for health development, Awaji Island, Japan. Van der Merwe, W., Hartley, P.S., Daubenton, J.D. & Desai, F. 2000. Acute tumour lysis syndrome: a retrospective analysis of 35 patients with Burkitt's Lymphoma and B-Cell acute lymphoblastic leukaemia. Proceedings of the 4th Continental meeting of International Society of Paediatric Oncology in Africa, Sun City, South Africa. (Abstract), 70. Weinberg, E.G. 2000. Urbanization and childhood asthma in South Africa. ACI International Suppl 1: 39-42. Wessels, G., Hartley, P.S., Hessling, P.B. & Rudman, D. 2000. Incidence and frequency rates of childhood cancer in the western cape: a first report from the poopulation based children's tumor registry of the Western Cape of South Africa. Woods, D.L. 2000. Invited paper: Neonatal resuscitation in South Africa- topics of controversy. South African Society of Anaesthesiologists Congress, Cape Town. Woods, D.L. 2000. A distance learning programme in perinatal care. 7th IAMANEH 2000 World Conference, Stellenbosch.
151
Woods, D.L. 2000. A comparison of the perinatal mortality rates for infants with a birth weight at or above 50g and 1000g. Research Day. Institute of Child Health, University of Cape Town. Woods, D.L. 2000. Poster: An innovative method of training midwives who care for women with HIV/AIDS. 13th International Aids Conference, Durban. Woods, D.L. 2000. A distance learning programme in perinatal care. 7th IAMANEH 2000 World Conference, Stellenbosch, 8-9. Zar, H.J., Tannenbaum, E., Apolles, P., Roux, P., Hanslo, D. & Hussey, G. 2000. The microbiological diagnosis of pulmonary tuberculosis in children - induced sputum compared to gastric lavage. South African Respiratory Journal 6(2): 119. Zar, H.J., Apolles, P., Argent, A., Klein, M., Burgess, J., Hanslo, D., Bateman, E. & Hussey, G. 2000. Aetiology and outcome of pneumonia in HIV-infected children admitted to intensive care in South Africa. American Journal Respiratory and Critical Care Medicine 161(3):A780. Zar, H.J., Hanslo, D., Apolles, P., Tannenbaum, E., Eley, B., Klein, M., Argent, A., Burgess, J., Magnus, K., Bateman, E.D. & Hussey, G. 2000. Aetiology and outcome of pneumonia in HIV- infected children admitted to hospital in South Africa. 13th International AIDS conference, Durban, South Africa 2: 54, WePpB1307. Zar, H.J., Langdon, G., Apolles, P., Eley, B., Hussey, G. & Smith, P. 2000. The pharmacokinetics of oral cotrimoxazole (TMP-SMZ) in children with HIV infection. 13th International AIDS conference, Durban, South Africa 2: 54, WePeB4117. Zar, H.J., Toerien, A., Stickells, D., Wilson, D., Klein, M. & Bateman, E.D. 2000. Changes in asthma mortality and morbidity in Cape Town, South Africa from 1980-1997. American Journal Respiratory and Critical Care Medicine 161(3):A624. Zar, H.J. & Weinberg, E.G. 2000. Spacer devices for the developing world. ACI International 2000. Zühlke, L. 2000. ALCAPA: an under recognised course of left ventricular dysfunction. Presented at the first congress of The South African Heart Association.
THESES AND DISSERTATIONS PASSED FOR HIGHER DEGREES
Marco, C. 2000. An evalaution of the impact of the introduction of the district health system on nurses employed in the public primary health care sector in Mitchell's Plein. M.Phil. dissertation (Paediatrics and Child Health), University of Cape Town. Wigton, A. 2000. Firearm-related injuries and deaths among children & adolescents in Cape Town. 1992-1996. M.Sc. dissertation (Paediatrics & Child Health), University of Cape Town. Zar, H.J. 2000. Pneumonia in HIV-infected children admitted to hospital in Cape Town, South Africa: 1-173. Ph.D. thesis, University of Cape Town.
UNIVERSITY PUBLICATIONS AND PUBLICATIONS OF A POPULAR NATURE AND OTHER
Abrahams, E. 2000. Health promoting schools: development of national policy guidelines. MCH News. 14:9-10. Case management guidelines and training materials. Desai, F., Hendricks, M. & Olivier, L. 2000. (on behalf of the Paediatric Case Management Guidelines Reference Group (PAWC)) Integrated Case Management Guidelines: Growth Monitoring. Desai, F., Hendricks, M. & Olivier, L. 2000. (on behalf of the Paediatric Case Management Guidelines Reference Group (PAWC)) Integrated Case Management Guidelines: Malnutrition. Desai, F., Hendricks, M. & Olivier, L. 2000. (on behalf of the Paediatric Case Management Guidelines Reference Group (PAWC)). Integrated Case Management Guidelines: Vitamin A Supplementation. Desai, F., Hendricks, M., Strasser, S. & Olivier, L. 2000. (on behalf of the Paediatric Case Management Guidelines Reference Group (PAWC)). Integrated Case Management Guidelines: Training package - growth monitoring, malnutrition and vitamin A deficiency. Giese, S. 2000. Providing for the orphan generation. ChildrenFIRST. Giese, S. 2000. The Children's HIV/AIDS Network : a co-ordinated response to the HIV/AIDS crisis. MCH News: 15. Guthrie, T. 2000. Tobacco and Youth: What in the World Works? MCH News: 13. Hussey, G. 2000. Immunisation. Baby and me. Mathambo, V. 2000. Child labour in South Africa. HST Update. Mathambo, V. 2000. Child Labour: how can we protect 'invisible workers'? Children FIRST 4(30):25- 27. Motala, C. 2000. Allergy Case Presentations. Physicians Refresher Course. Programme & Abstract Book, Monday 4 Wednesday 06 December 2000.
152
Motala, C. 2000. Management of chronic asthma in children. The Journal of Continuing Eduction for General Practitioners. Update 66 – 70. Proudlock, P. 2000. Gun Violence and Children. HST Update, June. Proudlock, P. 2000. The draft Firearms Control Bill: a step towards protecting children from gun violence. MCH News: 14:8. Proudlock, P. 2000. The Firearms Control Bill: Creating a culture of responsible gun ownership. ChildrenFIRST, February. Shung-King, M. 2000. Tobacco and Child Health. HST Update, May.
UNPUBLISHED RESEARCH/TECHNICAL/POLICY DOCUMENTS
Child Health Policy Institute. 2000. Social assistance policy for children with disabilities and chronic illness in South Africa. Child Health Policy Institute, University of Cape Town: Children's Rights project, Community Law Centre, University of the Western Cape. Giese, S. 2000. Commentary on the SALC's Consultative Paper: Children living with HIV/AIDS. Submission to the SALC. Giese, S. 2000. Social assistance for children made vulnerable by HIV/AIDS". Written submission to the National Committee of Inquiry into a Comprehensive Social Security System. Giese, S. 2000. Social assistance for children made vulnerable by HIV/AIDS. Oral submission to the Inter-departmental Committee of Inquiry into a Comprehensive Social Security System. Guthrie, T. & Proudlock, P. 2000. Tobacco Products Control regulations. Submission to the Dept of Health. Guthrie, T. 2000. Social Assistance for Children with Disabilities and HIV/AIDS: the Possibilities of the Care Dependency Grant. Oral & written submission made to the Inter-departmental Committee of Inquiry into a Comprehensive Social Security System. Guthrie, T., Giese, S. & Footner, L. 2000. Issue Paper on Social Security for Children in South Africa. Submission made to the Inter-departmental Committee of Inquiry into a Comprehensive Social Security System. Guthrie, T., ShungKing, M., Mathambo, V., Abrahams, E., Proudlock, P. & Giese, S. 2000. Policy Guidelines for Youth and Adolescent Health". Submission to MCWH, DOH. CHPI. Hann, M. 2000. Policy and guidelines on Kangaroo Mother Care for the Provincial Administration of the Western Cape Province. Hendricks, M. & Saitowitz, R. 2000. Fighting Vitamin A Deficiency: experiences and options for South Africa. Micronutrient Course for Southern Africa (CD-rom), Clive West and Jitske Brouwer (eds) Wageningen University, Netherlands. Irlam, J. 2000. Article in HST Update Issue 50 (March): Experiences with the Use of Infomation and Communication Technology (ICT) in a Distance Education Programme. Kibel, M., Slater, C., Hendricks, M., Hussey, G., Irlam, J. & Jacobs, M. 2000. Promoting Healthy Growth (CD-rom), Departments of Human Biology and Paediatrics and Child Health, University of Cape Town. Pillay, K. & Proudlock, P. 2000. South Africa's Constitutional and International Obligations with regard to Children with Disabilities. Child Health Policy Institute, UCT. Proudlock, P. & Shung-King, M. 2000. Firearms Control Bill: Oral presentation of submission before Portfolio Committee on Safety and Security. Proudlock, P. 2000. Firearms Control Bill. Submission to Parliament. Proudlock, P. 2000. Firearms Control Bill. Submission to Secretariat on Safety and Security. Proudlock, P. 2000. Overview of current SA policies, laws and programmes on Child Health Care - working document. Child Health Policy Institute, UCT. Proudlock, P. 2000. Policy and Legislation Framework - Children with disabilities and chronic illnesses: Their right to social security. Child Health Policy Institute, UCT. Proudlock, P., Giese, S., Booth, L. & Jenkins, F. 2000. Policy and Legislation Update, Editions: October 1999 onwards. Bi-monthly electronic publications. Shung-King, M., Proudlock, P. & Adnams, C. 2000. Foetal Alcohol Syndrome. Co-ordinated and facilitated presentation to the Portfolio Committee on Health. Shung-King, M., Proudlock, P. & Guthrie, T. 2000. Children on Philippi farms. Site tour for national and provincial parliamentarians, local government and community organisations. Swingler, G. 2000. Special feature: Paediatrics. Specialist Medicine XXII 1 January: 4. Westwood, A.R.T. 2000. The use of EEG in Childhood. Hospitals Supplies January: 3-6.
LETTERS
Heese, H. deV., Weinberg, E.G. & Power, H.M. 2000. Prevalence of Asthma in malnourished children. South African Medical Journal 90:1003. 153
Jones, G.D., Hatherill, M. & Murdoch, I.A. 2000. Excessive predicted mortality in acute hypoxaemic respiratory failure. Critical Care Medicine 28:600-601. London, L., Hussey, G., Keen, A. & Sachs, J. 2000. HIV and AIDS - open letter to the President of South Africa and the Minister of Health. South African Medical Journal 90: 444. Motala, C. & Lolloo, U.G. 2000. Guidelines for the management of chronic asthma on children and adults. South African Medical Journal 90(5): 488. Westwood, A.R.T. 2000. Childhood deaths due to HIV- the role of the new death certificate. South African Medical Journal: 877. Zar, H.J., Tannenbaum, E., Apolles, P., Hanslo, D. & Hussey, G. 2000. Sputum induction for the diagnosis of pulmonary tuberculosis. Arch Dis Child 83(3): 279.
154
DEPARTMENT OF PHARMACOLOGY (South African Medical Research Council Traditional Medicines Research Unit) (World Health Organization Collaborating Centre for Drug Policy)
HEAD OF DEPARTMENT: Professor Peter I Folb
DEPARTMENTAL CONTACT DETAILS
Postal Address: Department of Pharmacology University of Cape Town Medical School K45, Old Main Building Groote Schuur Hospital Observatory,7925 South Africa Telephone: SA (21) 406-6286 Fax: SA (21) 448-1989 email: [email protected]
DEPARTMENTAL PROFILE
Research in the department covers basic, applied and clinical pharmacology, and the department participates in a number of regional, national, continental (African) and international programmes.
The World Health Organization Collaborating Centre for Drug Policy, based in the department and functioning in conjunction with the School of Pharmacy of the University of the Western Cape, aims to spread information and to develop and promote systems and research that support rational and safe use of essential medicines by health professionals. This includes traditional medicines. Systems for monitoring safety are developed and drug toxicity countrywide is monitored. Collaboration with other developing countries is undertaken for the training of research workers and of teachers of pharmacology.
The department conducts a collaborative research programme, in conjunction with the Medical Research Council, into the early development of new antituberculosis combination drugs. New drug assay methods have been developed and clinical development of novel antituberculosis drugs is supported by clinical trials in patients and in healthy normal volunteers. In collaboration with the World Health Organization, novel antimalarial drugs are investigated as part of WHO international research programmes. A focus of the research of the department is to investigate the nature of antimalarial drug resistance.
Research is undertaken into the discovery of new antimalarial drugs and understanding the mechanisms of malaria parasite resistance to drugs (chloroquine, mefloquine and pyronaridine). Activity is tested in vitro of concentrated extracts of more than 100 plants against approximately 15 strains of Plasmodium falciparum.
South African Medical Research Council Traditional Medicines Research Unit: The MRC research unit, in conjunction with the University of the Western Cape School of Pharmacy, conducts, inter alia, laboratory research into activities of traditional medicines and their safety, with special reference to antimalarial agents, antivirals, and antituberculosis agents, co-operation with traditional healers and researchers, new drug registration, information and the provision of reference materials. A computerised database is being developed for use by researchers, traditional healers, other health professionals, and the public.
The National Adverse Drug Event Monitoring Centre based, in the department monitors adverse effects of medicines country-wide, and it aims to promote the safe use of medicines. The unit collects reports of apparent harm caused by drugs and vaccines, evaluates them and advises the Medicines Control Council, the national drug regulatory authority. 155
DEPARTMENTAL STATISTICS 2000
HONORARY STAFF PERMANENT AND LONG TERM Honorary Lecturers 3 CONTRACT STAFF TOTAL 3 Professor 1
Associate Professor 1 Senior Lecturers 2 STUDENTS Lecturers 4 Postdoctoral 1 Research Staff 16 Doctoral 15 Technical Support Staff 8 Masters 8 Administrative and Clerical 6 Honours 7 Staff Undergrad medical students 530 TOTAL 38 TOTAL 561
RESEARCH FIELDS
P.I. Folb clinical and experimental pharmacology; scientific basis of drug development; toxicology and drug safety, malaria P.J. Smith mechanisms of antimalarial drug resistance; pharmacokinetics of anti-TB drugs; isolation of novel drugs from traditional medicines; development of new drug assays A. Robins Psychopharmacology; Neuroleptic Malignant Syndrome;Catatonia; Antidepressants; Medical Ethics; Medical History; Evolution of Human Skin Pigmentation K.I. Barnes Malaria: treatment policy development and implementation, field research on artemisinin combination therapies; educational interventions in rational drug use H. McIlleron tuberculosis drug kinetics in patients; tuberculosis drug formulation quality and bioequivalence M. Blockman Rational and cost-effective prescribing of medicines; drug utilisation review; adverse drug reaction monitoring; drug policy and regulation W.E. Campbell Phytochemical studies on indigenous Amaryllidaceae species; structural studies on active compounds isolated from traditional medicinal plants U. Mehta Pharmacovigilance, vaccines safety, drug regulation, adverse drug reaction monitoring G. Gabriels tuberculosis, pharmacokinetics A. Evans malaria, drug assay development H. Hoppe malaria
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Campbell, W.E., Nair, J.J., Gammon, D.W., Codina, C., Bastida, J., Viladomat, F., Smith, P.J. & Albrecht, C.F. 2000. Bioactive alkaloids from Brunsvigia radulosa. Phytochemistry 53: 587 – 591. Chibale, K., Moss, J.R., Blackie, M., van Schalkwyk, D. & Smith, P.J. 2000. New amine and urea analogs of ferrochloroquine: synthesis, antimalarial activity in vitro and electrochemical studies. Tetrahedron Letts 41: 6231 – 6235. 156
Egan, T.J., Hunter, R., Kaschula, C.H., Marques, H.M. & Walden, J. 2000. Structure-function Relationships in Aminoquinolines: The Effect of Amino and Chloro Groups on the Quinoline- haematin Complex Formation, Inhibition of B-haematin formation and Antimalarial Activity. Journal of Medicinal Chemistry 43: 283-291. Gould, C. & Folb, P.I. 2000. The South African Chemical and Biological Warfare program: An overview. The non-proliferation review of the Monterey Institute of International Studies 7(2): 10-23. Gunston, G.D. & Mehta, U. 2000. Potentially serious drug interactions with grapefruit juice. South African Medical Journal 90(1): 41. Mehta, U. 2000. Potentially serious drug interactions between St John's Wort and other medicines. South African Medical Journal 90(7): 698. Mehta, U. 2000. Reporting of serious adverse events in neonates. South African Medical Journal 90(10): 997. Mehta, U., Gunston, G.D. & O'Connor, N. 2000. Serious consequences to misuse of propofol anaesthetic. South African Medical Journal 90(3): 240. Mehta, U., Milstien, J.B., Duclos, P. & Folb, P.I. 2000. Developing a national system for dealing with adverse events following immunisation. Bulletin of the World Health Organisation 78(2): 170- 175. Payne, K. & Mehta, U. 2000. Spinal/epidural haematomas associated with neuraxial anaesthesia in the presence of heparin and low-molecular-weight heparins. South African Medical Journal 90(6): 604. Peden, M., van der Spuy, J., Smith, P. & Bautz, P. 2000. Substance Abuse and Trauma in Cape Town. South African Medical Journal 90 (3): 251-255. Robins, A.H. & Sellars, S.L. 2000. Oscar Wilde's terminal illness: reappraisal after a century. Lancet 356: 1841-1843. Taylor, D., Walden, J., Robins, A. & Smith, P. 2000. The role of neurotransmitter reuptake blocking activity of antidepressants in the reversal of chloroquine resistance in Plasmodium falciparum in vitro. Antimicrobial Agents and Chemotherapy 44 (10): 2689-2692. White, D.A.C. & Robins, A.H. 2000. An analysis of 17 catatonic patients diagnosed with neuroleptic malignant syndrome. CNS Spectrum 5:58-65.
BOOKS
Gibbon, C.J., Barnes, K.I., Blockman, M., Folb, P.I., McIlleron, H., Orrell, C. & Robins, A.H. (eds) 2000. South African Medicines Formulary fifth edition. Cape Town: South African Medical Association Health and Medical Publishing Group.
CHAPTERS IN BOOKS
Folb, P.I. 2000. Cytostatics and immunosuppressive drugs. In Dukes, M.N.G. et al (eds) Meyler’s Side Effects of Drugs, Fourteenth Edition: 1538-1590. New York, London: Elsevier Science. Folb, P.I. 2000. Intravenous infusion- solutions and emulsions. In Dukes, M.N.G. et al (eds) Meyler’s Side Effects of Drugs, Fourteenth Edition: 1140-1170. New York, London: Elsevier Science.
CONFERENCE ABSTRACTS
Brine, N., Campbell, W., Bastada, J., Codina, C. Viladomat, F., Machocho, A. & Smith, P. 2000. An acetylcholinesterase inhibiting alkaloid from the South African Cyrtanthus sanguineus. Natural Products Research in the New Millennium, Zurich, Switzerland. Bastida, J., Codina, C., Viladomat, F., Campbell, W., Nair, J. & Brine, N. 2000. Alkaloids from South African Amaryllidaceae. VIIIth International Symposium on Flowerbulbs, Kirstenbosch, Cape Town, South Africa. Zar, H.J., Langdon, G., Apolles, P., Eley, B., Hussey, G. & Smith, P. 2000. The pharmacokinetics of oral cotrimoxazole (TMP-SMZ) in children with HIV infection. 13th International AIDS Conference, Durban, South Africa 2(54) WePeB4117. Elandalloussi, L. & Smith, P.J. 2000. Purification of Plasmodium facliparum plasma Membranes and characterisation of the parasite plasma membrane ATPase activity. Molecular Approaches to Malaria, Lorne, Victoria, Australia. Cockroft, J., Wash, P., Werely, C., Smith, P. & McIlleron, H. 2000. A phenotypic and genotypic study of acetylator status at Brewelskloof Hospital, Worcester. Presented at the TB Strategies for Africa Conference 2000, Cape Town.
157
McIlleron, H., Wash, P., Folb, P.I. & Smith, P.J. 2000. TB into the New Millennium, Cairns, Queensland, Australia. Proffered paper with published abstract and poster, all entitled ‘Low and variable rifampicin concentrations in tuberculosis patients. McIlleron, H., Wash, P., Cockroft, J., Wilkins, J., Fredericho, A., Van Dyk, J., Gabriels, G., Burger, A., Folb, P. & Smith, P. 2000. TB Strategies for Africa, Cape Town Technikon. Low and variable rifampicin concentrations in tuberculosis patients. Gould, C. & Folb, P.I. 2000. UNESCO: the South African chemical and biological warefare programme in the apartheid era: revelations of the National Truth and Reconciliation Commission, with special refernce to general implications for the conduct of science. The Millenium Symposium of Science, Society and Human Rights: Implementation of the UNESCO Declaration on Science and the Use of Scientific Knowledge for the 21st Century. Regina, Canada. Plenary presentation and publication in symposium proceedings. Folb, P.I. & Gomes, M. 2000. 11th International Conference on Pharmaceutical Medicine Berlin/Germany. Clinical trials in countries where certain drugs are not available.
THESES PASSED FOR HIGHER DEGREES
Elandalloussi, L.M. 2000. Characterization of the ATPase activity and the study of the chloroquine accumulation properties of purified Plasmodium falciparum plasma membranes. Ph.D. (Pharmacology) thesis, University of Cape Town.
UNIVERSITY AND OTHER PUBLICATIONS
Medicines Information Centre. 2000. What is Ddi? CME 18(1): 65. Medicines Information Centre. 2000. CME 18(1): 66-68. Medicines Information Centre. 2000. Is it safe to give albendazole to a sulphonamide-allergic patient? CME 18(1):66-68. Medicines Information Centre. 2000. Is mefloquine safe in porphyria? CME 18(1):66-68. Medicines Information Centre. 2000. Are tetracyclines safe in lactation? CME 18(1):66-68. Medicines Information Centre. 2000. Can a woman whose husband is on Roaccutane (isotretinoin) fall pregnant safely? CME 18(1):66-68. Medicines Information Centre. 2000. Which drug may be used to treat scabies in pregnancy. CME 18(1):66-68. Medicines Information Centre. 2000. Is there an interaction between warfarin and arnica? CME 18(1):66-68. Medicines Information Centre. 2000. Which drugs may not be used in patients with glucose-6- phosphate dehydrogenase (G6PD) deficiency? CME 18(1):66-68. Medicines Information Centre. 2000. Which drugs are more likely to cause oesophagitis? CME 18(1):66-68. Medicines Information Centre. 2000. Did you know how to use halofantrine? CME 18(1):66-68. Medicines Information Centre. 2000. Did you know the dose of doxycycline for the prophylaxis of malaria? CME 18(1):66-68. Medicines Information Centre. 2000. Substances allowed in competitive sport. CME 18(2):157. Medicines Information Centre. 2000. SA equivalents of some foreign oral contraceptives. CME 18(2):157. Medicines Information Centre. 2000. What is isoprinosine (Methisoprinol)? CME 18(2):158-160. Medicines Information Centre. 2000. Can atorvastatin cause sexual dysfunction? CME 18(2):158-160. Medicines Information Centre. 2000. Which drugs can safely be used for anaesthesia in patients with porphyria? CME 18(2):158-160. Medicines Information Centre. 2000. What are diethylcarbamezine and ivermectin? CME 18(2):158- 160. Medicines Information Centre. 2000. Are there any interactions between non-steroidal anti- inflammatory agents (NSAIDs) and lithium? CME 18(2):158-160. Medicines Information Centre. 2000. Can lignocaine be used for a dental procedure in a pregnant patient? CME 18(2):158-160. Medicines Information Centre. 2000. Is ethanolamine oleate still available in South Africa? CME 18(2):158-160. Medicines Information Centre. 2000. What are the options for treating bilharzia? CME 18(2):158-160. Medicines Information Centre. 2000. Is D-norpseudoephedrine safe in pregnancy? CME 18(2):158-160. Medicines Information Centre. 2000. What are the differences between two products containing mesalamine? CME 18(2):158-160. Medicines Information Centre. 2000. What is ebastine? CME 18(3):257-260.
158
Medicines Information Centre. 2000. Is it safe for a person who is allergic to co-trimoxazole to take ciprofloxacin? CME 18(3):257-260. Medicines Information Centre. 2000. What is Twinrix? CME 18(3):257-260. Medicines Information Centre. 2000. Is the flu vaccine contraindicated in patients on chemotherapy? CME 18(3):257-260. Medicines Information Centre. 2000. Can griseofulvin or doxycycline cause break-through bleeding in a patient on the combined oral contraceptive? CME 18(3):257-260. Medicines Information Centre. 2000. How safe is St John’s wort? CME 18(3):257-260. Medicines Information Centre. 2000. What is Black Cohosh and what is it used for? CME 18(3):257- 260. Medicines Information Centre. 2000. Can tobacco smoking alter the efficacy of drugs? CME 18(3):257- 260. Medicines Information Centre. 2000. How much of an alcohol-containing cough mixture needs to be consumed for a person’s blood alcohol level to exceed the limit for driving? CME 18(3):257- 260. Medicines Information Centre. 2000. What is Synercid? CME 18(3):257-260. Medicines Information Centre. 2000. What alternatives are there to sulfasalazine for ulcerative colitis in a sulfasalazine allergic patient? CME 18(4):354-356. Medicines Information Centre. 2000. Is Primaquine safe to ue in a glucose-phosphate dehydrogenase (G6PD)-deficient patient? CME 18(4):354-356. Medicines Information Centre. 2000. Which antifungal can be used to treat severe tinea corporis in a patient with compromised renal function? CME 18(4):354-356. Medicines Information Centre. 2000. Is propylthiouracil safe in pregnancy? CME 18(4):354-356. Medicines Information Centre. 2000. Can mefloquine be used in a patient allergic to sulphur? CME 18(4):354-356. Medicines Information Centre. 2000. Can nystatin be safely used to treat candidal vaginal infections in pregnancy? CME 18(4):354-356. Medicines Information Centre. 2000. Could agnus castus interfere with thyroxine therapy? CME 18(4):354-356. Medicines Information Centre. 2000. What is Proleukin? CME 18(4):354-356. Medicines Information Centre. 2000. What is SAMe? CME 18(4):354-356. Medicines Information Centre. 2000. Prevention of mother-to-child transmission of HIV. CME 18(5):445-447. Medicines Information Centre. 2000. Can secretin be used to treat autism? CME 18(5):447-448. Medicines Information Centre. 2000. How effective are the new antiviral combinations for the treatment of HIV? CME 18(5):447-448. Medicines Information Centre. 2000. Can NSAIDs reduce the efficacy of diuretics? CME 18(5):447- 448. Medicines Information Centre. 2000. Are anticonvulsants useful for neuropathic pain? CME 18(5):447- 448. Medicines Information Centre. 2000. What are ‘Sextasy’ and ‘Liquid Ecstasy’? CME 18(5):447-448. Medicines Information Centre. 2000. Can liquorice decrease testosterone levels? CME 18(5):447-448. Medicines Information Centre. 2000. Are there any interactions between conjugated oestrogens and warfarin? CME 18(5):447-448. Medicines Information Centre. 2000. What can one expect when changing between Berotec and Ventolin? CME 18(5):447-448. Medicines Information Centre. 2000. Can fluoxetine cause visual disturbances? CME 18(5):447-448. Medicines Information Centre. 2000. What is the current malaria situation in the Kruger National Park and the Kalahari Gemsbok game reserve? CME 18(5):447-448. Medicines Information Centre. 2000. What is the significance of drug interactions with grapefruit? CME 18(6):541-544. Medicines Information Centre. 2000. What is rizatriptan and does it interact with propranolol CME 18(6):541-544. Medicines Information Centre. 2000. Is there an interaction between carbamazepine and combined oral contraceptives? CME 18(6):541-544. Medicines Information Centre. 2000. Is there an interaction between itraconazole and primidone? CME 18(6):541-544. Medicines Information Centre. 2000. How does one use cyproheptadine to treat SSRI-induced anorgasmia? CME 18(6):541-544. Medicines Information Centre. 2000. What is sirolimus and is it available in South Africa? CME 18(6):541-544. Medicines Information Centre. 2000. What is the South African equivalent of Premique? CME 18(6):541-544. 159
Medicines Information Centre. 2000. What is laetrile? CME 18(6):541-544. Medicines Information Centre. 2000. What is Plan B, the new ‘morning-after’ pill? CME 18(6):541- 544. Medicines Information Centre. 2000. What is the difference between folic acid and folate? CME 18(6):541-544. Medicines Information Centre. 2000. The safe use of paracetamol – Poster inserted into SAPJ/Pharmacy Management, March. Swart, A. (ed.) 2000. Malaria Update 2000/1 4th edition. Cape Town: Medicines Information Centre. Gibbon, C. 2000. Prescribing Antidepressants. http://www.cpdsa.co.za. Medicines Information Centre. 2000. Malaria Part One – Epidemiology, Etiology and Diagnosis. http://www.cpdsa.co.za. Medicines Information Centre. 2000. Malaria Part Two – Non-drug preventative measures. http://www.cpdsa.co.za. Medicines Information Centre. 2000. Malaria Part Three – Chemoprophylaxis – A guide to choosing appropriate drugs. http://www.cpdsa.co.za.
TECHNICAL REPORTS
McIlleron, H., Smith, P., Harwarden, D., Gabriels, G. & Fourie, B. 2000. Bioavailability study comparing Rifater Combination Dispersable Tablets (Rifampicin 60mg, Isoniazid 30 mg and Pyrazinamide 150mg) as a single dose to equivalent doses of NORISTAN-ISONIAZID®, ROZIDE and RIFADIN® as a single dose, in healthy volunteers. Department of Pharmacology, University of Cape Town. McIlleron, H., Smith, P., Harwarden, D., Gabriels, G. & Fourie, B. 2000. Bioavailability study comparing Rifinah Combination Tablets (Rifampicin 60mg and Isoniazid 30mg) as a single dose to equivalent doses of NORISTAN-ISONIAZID®, and RIFADIN® as a single dose, in healthy volunteers. Department of Pharmacology, University of Cape Town. McIlleron, H., Smith, P., Gabriels, G. & Fourie, B. 2000. The bioavailability and bioequivalence of Rifampicin, Isoniazid and Pyrazinamide as a single dose in a fixed dose combination formulation, Rimcure 3-FDC Intermittent, compared to equivalent doses of single drug reference preparations of the three drugs. Department of Pharmacology, University of Cape Town. McIlleron, H., Smith, P., Gabriels, G. & Fourie, B. 2000. The bioavailability and bioequivalence of Rifampicin and Isoniazid as a single dose in a fixed dose combination formulation, Rimactazid 150/75, compared to equivalent doses of single drug reference preparations of the two drugs. Department of Pharmacology, University of Cape Town. McIlleron, H., Smith, P., Gabriels, G. & Fourie, B. 2000. The bioavailability and bioequivalence of Rifampicin and Isoniazid as a single dose in a fixed dose combination formulation, Rimactazid 150/150, compared to equivalent doses of single drug reference preparations of the two drugs. Department of Pharmacology, University of Cape Town. McIlleron, H., Smith, P., Gabriels, G. & Fourie, B. 2000. Bioavailability study comparing Rifater Combination Dispersible Tablet (Rifampicin 60 mg, Isoniazid 30 mg and Pyrazinamide 150 mg) as a single dose to equivalent doses of Norstan-Isoniazid®, Rozide® and Rifadin® as a single dose, in healthy volunteers. Department of Pharmacology, University of Cape Town. Gomes, M., Ribeiro, I. & Folb, P.I. 2000. Report to National drug regulatory authorities of the United States (Food and Drug Administration), United Kingdom (Medicine Control Agency), and Switzerland (Intercantonal office for the control of medicines: Development of artesunate for rectal administration for life-threatening malaria and to work towards bringing artesunate to submission for regulatory approval by authorities of the United States (Food and Drug Administration), United Kingdom (Medicines Control Agency), and Switzerland (Intercantonal Office for the Control of Medicines); and implementation of the drug with a view to achieving a 40% reduction in morality from severe malaria in several malaria-prevalent countries of the world (Ghana, Nigeria, Tanzania and Bangladesh, in the forst instance); (27 volumes, and hyperlinked CD Rom). Department of Pharmacology, University of Cape Town.
CONSULTANCIES AND OTHER RESEARCH AND SPECIAL APPOINTMENTS
Barnes, K.I. Member of National Malaria Advisory Group Department of Health, and of the Sub- committee for Chemo-prophylaxis and Therapy Member of the National Malaria Collaborative Forum. Member of South Africa Malaria Advisory Group, and its sub-committee on Chemoprophylaxis and Therapy. Department of Health. Drug Information Association, USA: Member of the Steering Committee for International Development (representative for Sub-Saharan Africa). 160
World Health Organisation: Temporary Advisor to the Pyronaridine Product Development Team, (2000); Temporary Advisor to the Artesunate Development Task Force. Orrell, C. Cross-site facilitator in Rational Drug Use for the Initiative for Sub-district Support, part of Health Systems Trust. Boyce, T.A. Member: Steering Committee for the National Drug Information Network of the South African Department of Health and the national Drug Action Programme (1998); Member: Southern African Consulting group on Consumer Involvement in National Drug Policy for Health Action International (1999). Blockman, M. Chair: Editorial Expert Committee; sub-committee of the National Essential Drugs List Committee; Department of National Health. Gibbon, C. Member: Editorial Expert Committee; Department of Health; edited the publication 'Standard South African Standard Treatment Guidelines and Essential Drugs List for Hospital Level, 2000 Edition (Published by Department of Health). Matsabisa, G. serves on the complementary medicines committee of the Medicines Control Council. Mehta, U. & Folb, P.I. Department of Pharmacology have been designated as the international training centre on Adverse Events following Immunization as part of the Global Training Network of the World Health Organisation (WHO). Folb, P.I. Director: World Health Organisation Collaborating Centre for Drug Policy at the University of Cape Town and the University of the Western Cape. Member: Steering committee of Medecins sans Frontieres initiative for scienctific development of novel drugs for neglected diseases in the developing world. Member: World Health Organization Strategic Advisory Group of Experts for vaccines policy worldwide (includes vaccine safety, novel vaccine development, worldwide eradication programmes, vaccine policy issues of international importance.) Chair: World Health Organization task force for research into severe malaria. Chair: World Health Organization task force for development of artesunate in severe, life- threatening malaria. Member: World Health Organization task force for research into malaria drud resistance and policies. Chair: World Health Organization global advisory committee for vaccine safety worldwide. In addition, in 2000 Professor Folb conducted country review visits on behalf of the World Health Organization to deal variously with issues of medicines and vaccine safety, new drug development, research capability training and strengthening, and establishment of clinical research centres in several countries. These countries were Poland, Tanzania and Armenia ( the latter in vaccine safety training, together with Dr U Metha, for the countries of the Former Soviet Union). In 2000, the Department of Arts, Culture, Science and Technology (DACST) awarded 6.7 million rand to a consortium to conduct research aimed at discovery of novel antimalarial agents from traditional medicinal sources. The Medical Research Council, Council for Scientific and Industrial Research, National Botanical Institutes, University of Pretoria and University of Cape Town are the participating members of the consortium. Professor P Folb was designated project leader of the research programme.
161
DEPARTMENT OF PHYSIOTHERAPY
Head of Department – Mrs M J Futter
DEPARTMENTAL CONTACT DETAILS
Postal address: Department of Physiotherapy Medical School Anzio Road Observatory 7925 South Africa Telephone: SA (21) 406-6402 Fax: SA (21) 448-8157 E-mail: [email protected]
DEPARTMENTAL PROFILE
The Department caters for 167 undergraduate and 20 postgraduate students. It has suffered severely from the reduction in staffing imposed by the Provincial Administration. Several services have had to be cut whilst others have been curtailed. However, the upper echelons of the staffing remain unchanged and this has been essential to maintaining staff morale and the continued functioning of the services of the Department. Services that have been frozen or abolished in the Community Health Centres utilised for undergraduate teaching are now being run entirely by students of this Department. This has meant employing a large number of part-time clinical supervisors to ensure that the undergraduate education continues at all levels of health care and to ensure that the management the clients receive is of a high standard. The Allied Health Sciences and Nursing departments held a very successful second Research Colloquium at the end of the year. Areas where capacity of the staff need to be improved were identified and future workshops will be held to address these aspects. As the Dean has made money available for these Departments to finish research projects that have been waiting for grants and seed moneys for new projects there should be a number of projects that will be completed during 2001.
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG TERM STUDENTS CONTRACT STAFF Associate Professors 1 Doctoral 1 Senior Lecturers 3 Masters (M.Phil. 16 Lecturers 3 Sports Physio) Junior Research Assistant 1 MSc(Physio) 3 Administrative and Clerical Staff 2 Undergraduate 167 TOTAL 10 TOTAL 187
RESEARCH FIELDS
PERMANENT STAFF
Mrs M.J. Futter Head of Department; Curriculum development; examination reliability and validity & Recruitment of Black students from schools previously administered by the DET Associate Professor P. Bowerbank Assessment of the organisation forces for change and the position and role of professional women in health care organisation; the development of multidisciplinary learning experience for undergraduate health professionals; the strategic development of a health care organisation: a longitudinal study of the South African Physiotherapy Profession 162
Mrs J.A Fourie Senior lecturer: Reconciliation in South Africa; the indicators for survivors, perpetrators and bystanders Ms S. Maart Lecturer joined staff in November; Women’s health; the educational process of clinical supervision Ms J. Hughes Lecturer joined staff in July; Registering for Masters next year Ms G. Mji Lecturer, Writing up a Masters thesis; Community-based rehabilitation facilities in Africa; rehabilitation needs homeless people living in Cape Town Ms H. Mashego Lecturer, Registered for Masters in Public Health (UWC) Mr S. Sifundza Junior Research Assistant, Registered for MPhil in Public Health (UCT); The level of functional independence and knowledge of disease in Diabetics with lower limb amputations attending the GSH Rehabilitation Unit
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Bowerbank, P. 2000. The strategic Development of Physiotherapy in South Africa: Some theoretical concepts which relate to organisational change. South African Journal Physiotherapy 56(3): 4-7. Buck, R.G., Miles, A.J. & Erlich, R.I. 2000. Possible occupational Asthma among adults presenting with acute asthma. South African Medical Journal 90(9): 884-888. Fourie, J.A. 2000. The Psychology of Perpetrators of ‘Political’ Violence in South Africa- a personal experience. Ethnicity & Health 5(3/4): 283-289.
CHAPTERS IN BOOKS
Fourie, J.A. 2000. A personal encounter with perpetrators of political violence In Villa-Vicencio, C. & Verwoerd, W. (eds) Looking back Reaching Forward: 230-238. Cape Town: UCT Press; London: Zed Books.
CONFERENCE ABSTRACTS
Futter, M. 2000. Level of functional improvement after prolonged delay before intervention of neurological rehabilitation. Second Pan-Pacific conference on Rehabilitation, Hong Kong.
UNPUBLISHED UNDERGRADUATE RESEARCH
Aboo, M., Halkett, D., Kriel, F. & Sutcliffe, C. 2000. How do Health Care Workers feel about working in a perceived unsafe area. Department of Physiotherapy, University of Cape Town. Abrahams, L., Abratt, D., Crowhurst, N., Lucani, L. & Osborne, L. 2000. A study of students perceptions of comfort in relation to desk-seat design in lecture theatres of the UCT Faculty of Health Sciences. Department of Physiotherapy, University of Cape Town. Berowsky, M., Hattingh, L., Hunt, L. & Ball, K. 2000. An Investigation into the benefits of a walking programme for postnatal women. Department of Physiotherapy, University of Cape Town. Barday, M., Dalvie, S., Hassim, N., Karachi, F. & Samsodien, W. 2000. The prevalence of back and/or neck pain in female clothing factory workers. Department of Physiotherapy, University of Cape Town. Barnes, M., Bradshaw, J., Hulbert, F. & Symonds, M. 2000. Life with Rheumatoid Arthritis - a qualitative study. Department of Physiotherapy, University of Cape Town. Benjamin, N., Selepe, M. & Tshabalala, M. 2000. Traditional Healers; consultation, tariffs and their healing approaches. Department of Physiotherapy, University of Cape Town. Bunn, S., Daya, S., Friederichs, T. & Stokes, K. 2000. An investigation into the effect of manual massage in reducing muscle soreness and promoting muscle recovery in female runners following an ultra-marathon. Department of Physiotherapy, University of Cape Town. Coates, G., De Klerk, J., Goosen, A., Holderness, J. & Hurwitz, J. 2000. An investigation into the adherence of school water polo Coaches to the recommended training procedures for the prevention of shoulder injury. Department of Physiotherapy, University of Cape Town. 163
Dorsett, R. & Berenisco, M. 2000. The quality of life and disease awareness in Diabetic patients who have undergone below knee amputation. Department of Physiotherapy, University of Cape Town.
TECHNICAL/POLICY DOCUMENTS
Fourie Ginn, J.A. & Mji, G. 2000. The Quest for Employment. Physio Forum, Newsletter of the SA Society of Physiotherapy 14 (4): 11-13.
164
DEPARTMENT OF PLASTIC, RECONSTRUCTIVE & MAXILLO- FACIAL SURGERY
HEAD OF DEPARTMENT - Professor D A Hudson
DEPARTMENT CONTACT DETAILS
Postal address: Department of Plastic & Reconstructive Surgery University of Cape Town Medical school Groote Schuur Hospital H53 Old Main Building Observatory 7925 South Africa Telephone: SA (21) 404-3426 / 406-6415 Fax: SA (21) 448-6461 Email: [email protected]
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG TERM HONORARY STAFF CONTRACT STAFF Emeritus Professor 1 Associate Professor 1 TOTAL 1 Lecturers (full-time) 1 STUDENTS Lecturers (part-time) 7
Administrative and Clerical 1 Masters (College) 5 Staff TOTAL 5 TOTAL 10
RESEARCH FIELDS
Associate Professor D A Hudson Hand trauma, breast surgery, skin tumours Dr D Lazarus Cleft lips & palate
RESEARCH PAPERS & REFERED ARTICLES
Skoll, P.J., Hudson, D.A., de Jager, W. & Singer, M. 2000. Long Term results of Tendon Transfers for radial nerve palsy in patients with limited rehabilitation. Annals of Plastic Surgery 45:122-126. Hudson, D.A. & Skoll, P.J. 2000. Aesthetic correction of a contour deformity of the neck with buried expanded flaps. Annals of Plastic Surgery 44:664-667. Jandera, V., Hudson, D.A., de Wet, P.M. et al. 2000. Cooling the burn wound: evaluation of different hospitals. Burns 26:265-270.
165
DEPARTMENT OF PRIMARY HEALTH CARE
HEAD OF DEPARTMENT - Professor Dumo Baqwa
DEPARTMENT CONTACT DETAILS
Postal Address: J Floor, Old Groote Schuur Hospital Observatory 7925 South Africa Telephone: SA (21) 406-6510 Fax: SA (21) 406-6667 Email: [email protected]
DEPARTMENTAL PROFILE
The Department of Primary Health Care is extensively involved in multidisciplinary community-based teaching with a strong focus on primary care training. It successfully runs an innovative first year foundation programme for medical, occupational therapy and physiotherapy students. It co-jointly runs a Primary Care module with the third year Clinical Methods course offered in the Department of Medicine. Other programmes include the 4th year Primary Health Care / Family Medicine block run jointly with the Department of Public Health, the 6th year Primary Health Care / Family Medicine block and the 3 year M.Phil. in Primary Health Care / Family Medicine.
The department has established and maintains international and national collaborative links with similar departments in tertiary institutions in the Western Cape, UK, Belgium and the United States to enhance its research and teaching capacity in the above areas.
The Department of Primary Health Care places its focus on research on a set of objectives that embraces the Comprehensive Primary Health Care Approach.
1. To develop capacity in Health Systems Research at all levels in under- and post-graduate education and training as well as to contribute to Health Systems Research skills in health managers responsible for Primary Health Care development. 2. To engage in further health policy work and to pay close attention to implementation strategies. 3. To examine the effectiveness and efficiency of primary care interventions – the point of entry into formal health care. Evidence-based medicine would be a particular area of focus.
4. To explore the framework of district-based health care. This includes: Informatics and health information systems Integrated health involving:
Investigation of a balanced and effective incorporation of the types of care (curative, preventive, promotive, protective and rehabilitative care) Multi-disciplinary teaching format with its impact on team building in service provision Public and private health sector mix that would optimise health outcomes
Investigating aspects of social, community-based and home care with a view to analyse the interface between formal and informal health care
5. Medical Education including: Curriculum development Teaching methodologies Problem-based and problem-oriented learning Small group teaching Raising the significance of the populations-based perspective for education and training. 166
DEPARTMENTAL STATISTICS
PERMANENT AND LONG TERM HONORARY STAFF CONTRACT STAFF Honorary Lecturers 1 Professors 1 TOTAL 1 Lecturers 12 Administrative & Clerical 1 STUDENTS Staff Masters 8 TOTAL 14 Undergraduate 570 TOTAL 578
RESEARCH FIELDS
PERMANENT STAFF
Professor Dumo Baqwa Head of Department Ms Melanie Alperstein Site Development Co-ordinator Ms Daleen Baker Site Development Co-ordinator Dr Graham Bresick Lecturer Ms Cecily Camara Lecturer Dr Elma de Vries Lecturer Dr Beverley Schweitzer Lecturer Dr Judith van Heerden Lecturer Ms Lauraine Vivian Lecturer Ms Adielah van der Schyff Secretary Mr Gavin Weir Lecturer
CONTRACT STAFF
Ms Mercia Arendse Site Facilitator Ms Linda Mgqamgqo Site Facilitator Ms Spectorine Mtshofeni Site Facilitator Ms Lorna Olckers Site Facilitator Dr Laurel Baldwin-Ragaven Lecturer Dr Stan Levenstein Lecturer Dr Sid Mobbs Lecturer Dr Miriam Navsa Lecturer Dr Stephen van Houten Lecturer 167
DISTINGUISHED VISITORS
Ms Vari Drennan University College London Medical School, London, UK; education and continuing professional development of nurses working in primary health care in South Africa Dr Irwin Nazareth University College London Medical School, London, UK; Epidemiology of Clinical presentations in a South African Primary care setting Dr Tim Stanton Director of Public Service Medical Scholars, Stanford University Medical School, USA; Service learning in medical education Dr Amar Jesani Director of Centre for Enquiry into Health and Allied Themes (CEHAT), University of Mumbai, India; Social Science research in health and health services Dr Jumana Odeh-Issawi Director of the Palestinian Happy Child Centre in Jerusalem; Consultant to Oxfam, UNICEF and Save the Children (USA); Human Rights and the Rights of the Child Dr Jack Bryant President of the Council for International Organisation of Medical Sciences (CIOMS), WHO, Geneva; Primary Health Care in medical education in developing countries Dr Len Rubenstein Head of Physicians for Human Rights (USA); Health and Human Rights
RESEARCH ASSOCIATES
Dr EM Mankazana Health Development Institute Dr S Yasin Harneker Health Development Institute
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Van Heerden, J. 2000. Health Care at Police Stations. South African Medical Journal 90: 234-236.
BOOKS AND CHAPTERS IN BOOKS
Bresick, G. 2000. Family Oriented Primary Care. In Mash, R. (ed.) Handbook of Family Medicine: 88- 120. Oxford University Press. Schweitzer, B. 2000. Management Skills in the Consultation. In Mash, R. (ed.) Handbook of Family Medicine: 150-173. Oxford University Press. Schweitzer, B. 2000. Putting Principles into Practice. In Mash, R. (ed.) Handbook of Family Medicine: 174-222. Oxford University Press.
CONFERENCE PAPERS AND PRESENTATIONS TO THE PUBLIC
Alperstein, M., Arendse, M., Mgqamgqo, L. & Mtshofeni, S. 2000. Health Promotion: Re-orienting Health Professional. Poster presentation at the Ottawa in Africa Conference. Alperstein, M. & Olckers, L. 2000. Multi-disciplinary Education for Health Sciences Students. Poster presentation at the Ottawa in Africa Conference. Schweitzer, B. 2000. The use of Standardised Patients in Teaching Family medicine at UCT. Paper presented at Ottawa in Africa pre-conference symposium. Schweitzer, B., Bresick, G. & Baldwin-Ragaven, L. 2000. Getting to the bottom of patients’ problems: the three stage assessment as a tool for teaching and learning. Paper presented at the Ottawa in Africa conference. Van Heerden, J. & Olckers, L. 2000. Beyond Pathophysiology: learning how to listen better. Poster presentation at the Ottawa in Africa Conference.
168
UNPUBLISHED RESEARCH/TECHNICAL/POLICY DOCUMENTS
De Villiers, M. & Bresick, G. 2000. A Qualitative Evaluation of a small group learning approach to CPD. Camara, C. 2000. Evaluation of graduates and current final year students’ experiences of the medical undergraduate programme. Camara, C. 2000. Health of Children at Risk: Street Children Project. Alperstein, M. 2000. Indigenous Knowledge of the Elderly regarding the treatment of minor ailments and maintenance of health in Khayelitsha. Baqwa, D.J. 2000. In search of an effective mechanism for poverty eradication. Paper presented at a strategy workshop of the government, NGOs and private sector. Baqwa, D.J. 2000. Transforming of the Health System: The Quest for Fresh Answers. Paper presented at the University of Ghent, Belgium. Baqwa, J.D. 2000. Primary Health Care: An Illusory Phenomenon or a Living Dynamic Concept? Paper presented in Namibia. Baqwa, J.D. 2000. The Goven Mbeki Foundation for Research in Primary Health Care. Paper presented at the Network for Primary Care Research Group, USA.
THESES AND DISSERTATIONS PASSED FOR HIGHER DEGRESS
Alperstein, M. 2000. An evaluation of a community-based multi-disciplinary teaching programme for health sciences students. M.Phil. (Adult Ed.) dissertation: University of Cape Town.
169
DEPARTMENT OF PSYCHIATRY AND MENTAL HEALTH
HEAD OF DEPARTMENT – Professor Brian Robertson
DEPARTMENTAL CONTACT DETAILS Postal Address: Department of Psychiatry University of Cape Town Groote Schuur Hospital Observatory 7925 South Africa Telephone: SA (21) 404-2164/447-5450 Fax: SA (21) 448-8158 e-mail: [email protected]
DEPARTMENTAL PROFILE The Deparment of Psychiatry and Mental Health continues to consolidate and expand its research efforts in three main domains: mental health services research, adolescent health.and infant mental health. Much of the research is of an applied nature and is paralleled by involvement in policy initiatives on the national and international levels. The international involvement is facilitated by the fact that the department is a World Health Organisation (WHO) Collaborating Centre for Research and Training in Mental Health; the only World Federation for Mental Health Collaborating Centre for Mental Health in Africa; and a leading participant in two European Commission-funded Concerted Action Projects which involve partners from several African and European countries.
So far as mental health services research is concerned, plans have been finalised for an evaluation of the Empilweni Project, which is a community-based mental health project staffed by lay counsellors in Khayalitsha. Work is in progress for a WHO contract to develop evidence-based mental health service guidelines for use by countries at all levels of development. The adolescent health research has two main foci: analysis of cross-sectional and longitudinal data sets involving risk behaviour by about 20,000 school students in Cape Town, Durban and three rural communities; and the development and evaluation of intervention projects that aim to reduce the extent of risk behaviour by high-school students. Also, consultancies have been completed for the development of national policy guidelines for the national Department of Health for (a) child and adolescent mental health and (b) adolescent and youth heath. There are two projects involving infant mental health. One is a prospective randomised control trial to assess the impact on infant development of an intervention to reduce postnatal depression. The other documents the effects of prenatal alcohol ingestion on infant growth and behaviour and mother-infant interaction.
Finally, a highlight of the year was the establishment of a Centre for the Study of Violence and Mental Health. Besides conducitng research, this Centre will offer services such as consultation, training, project evaluation, networking, referral, policy development and advocacy.
DEPARTMENTAL STATISTICS 2000
HONORARY STAFF PERMANENT AND LONG TERM
CONTRACT STAFF Lecturer 4 Professors 2 TOTAL 4 Associate Professors 3 STUDENTS Senior Lecturers Full-time 9
Lecturers Full-time 16 Senior Lecturers Part-time 4 Doctoral 2 Lecturers Part-time 8 Masters 34 Research Staff 4 Undergraduate 275 Post-doctoral Fellow 1 TOTAL 311 Administrative and Clerical Staff 2 TOTAL 49 170
RESEARCH FIELDS
PERMANENT STAFF
Professor Brian Robertson Head of Department- child and adolescent psychiatric epidemiology; impact of violence on children; development of community mental health services; integration of mental health services at primary care level; youthful perpetrators of violent crime; cultural psychiatry and indigenous healers Professor Chris Molteno infant mental health; foetal alcohol syndrome; psychopathology in children with mental handicap; the relationship between birth asphyxia and developmental disability Associate Professor Tuviah Zabow Deputy Head of Department; quality assurance and accreditation in psychiatry; the management of impaired medical practitioners and students; mental health legislation Associate Professor Alan Flisher adolescent risk behaviour; epidemiology of suicide; mental health services research; epidemiology of psychiatric disorder in children and adolescents Dr Astrid Berg Senior Lecturer; effects of maternal iron deficiency anaemia on infants Mr Andrew Carlyle Senior Lecturer; psychological aspects of infertility Dr Charles Malcolm Senior Lecturer; post-conflict models and alternatives for community rebuilding and reconciliation; leadership within contexts of post-conflict change and globalization; youth offender risk and resilience; professional ethics; the organization of violence and the status of perpetrators Dr Don Wilson Senior Lecturer; social phobia; panic states; substance misuse Dr Carl Ziervogel Senior Lecturer; alcohol use in school children
CONTRACT RESEARCH STAFF
Dr Ian Lockhart Senior Scientific Officer; develoment of mental health service guidelines Ms Wanjiru Mukoma Scientific Officer; evaluation of school-based AIDS prevention programmes Mr Chrisostomos Zissis Senior Research Officer; community based mental health care, evaluation and provision of innovative and appropriate mental health services in sub-Saharan Africa, effective models of consultation and training , psychological aspects of exposure and perpetration of violence
POST-DOCTORAL RESEARCH FELLOW
Dr Catherine Ward psychosocial effects of exposure to trauma; prevention of post-traumatic stress disorder and other negative consequences of exposure to trauma; psychosocial aspects of disaster management
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Eaton, E. & Flisher, A.J. 2000. HIV/AIDS knowledge among South African youth. Southern African Journal of Child and Adolescent Mental Health 12:97–124. Flisher, A.J., Kramer, R.A., Hoven, C.W., King, R.A., Bird, H.R., Davies, M., Gould, M.S., Greenwald, S., Lahey, B.B., Regier, D.A., Schwab-Stone, M. & Shaffer, D. 2000. Risk behavior in a community sample of children and adolescents. Journal of the American Academy of Child and Adolescent Psychiatry 39:881-887.
171
Flisher, A.J., Parry, C.D.H. & Stein, D. 2000. To what extent does South African mental health research address priority issues? South African Medical Journal 90: 378 - 380. Molteno, C.D. & Kench, E. 2000. Distance learning and training of trainers of trainers for persons who work with children with special needs in the Western Cape Province of South Africa. African Journal of Special Needs Education 5:27-34. Molteno, C.D., Smit, I., Mills, J. & Huskisson, J. 2000. Nutritional status of patients in a long-stay hospital for mental handicap. South African Medical Journal 90:1135-1140. Klepp, K-I., Fuglesang, M., Flisher, A.J., Leshabari, M.T., Lie, G.T. & Mapanga, K.G. 2000. The Adolescent Reproductive Health Network: Health System and Health Promotion Research in Eastern and Southern Africa. East African Medical Journal 77: S38-S42. Lund, C., Flisher, A.J., Lee, T., Porteus, K. & Robertson, B.A. 2000. A model for estimating mental health service needs in South Africa. South African Medical Journal 90:1019-1024. Morojele, N.K., Parry, C.D.H., Ziervogel, C.F. & Robertson, B.A. 2000. Prediction of binge drinking intentions of female school-leavers in Cape Town, South Africa, using the theory of planned behaviour. Journal of Substance Use 5:240-251. Ziervogel, C.F. 2000. Selective serotonin re-uptake inhibitors for children and adolescents. European Child and Adolescent Psychiatry 9 (Suppl. 1):1-7. Zissis, C., Ensink, K. & Robertson, B.A. 2000. A community study of taxi violence and distress symptoms among youth. Southern African Journal of Child and Adolescent Mental Health 12:151-161.
CHAPTERS IN BOOKS
Flisher, A.J., Cloete, K., Johnson, B., Wigton, A., Adams, R. & Joshua, P. 2000. Health promoting schools: rationale and pilot project. In Donald, D., Dawes, A. & Louw, J. (eds) Addressing Childhood Adversity: Psychosocial Interventions in South Africa: 113-130. Cape Town: David Phillip.
CONFERENCE ABSTRACTS
Flisher, A.J. 2000. Interventing through school systems. 9th International Conference on Treatment of Addictive Behaviours, Cape Town (invited plenary address). Flisher, A.J. 2000. Recent developments in South African Psychiatric Services. 11th National Psychiatry Conference (World Psychiatric Association Co-Sponsored Meeting), Durban. Flisher, A.J. 2000. Risk and protective factors in adolescent health. WHO/UNICEF meeting on “Protective and risk factors for adolescents from different countries: What can we measure?”, Geneva. Flisher, A.J. 2000. School-based surveys. 3rd WHO/UNICEF Meeting on “Programming for Adolescent Health and Development: What Should We Measure and How”, Washington DC. Flisher, A.J., Butau, T., Mbwambo, J., Aarø, L., Eide, A., Kaaya, S., Kilonzo, G., Lombard, C., Muller, M. & Klepp, K-I. 2000. Substance use by students aged 13-14 years in South Africa, Tanzania and Zimbabwe. 2nd World Psychiatric Association and Ugandan Psychiatric Association Regional Psychiatric Conference, Kampala, Uganda. Also presented at the 11th National Psychiatry Conference (World Psychiatric Association Co-Sponsored Meeting), Durban. Flisher, A.J., Evans, J., Muller, M. & Lombard, C. 2000. Reliability of self-reported risk behaviour of adolescents. 2nd World Psychiatric Association and Ugandan Psychiatric Association Regional Psychiatric Conference, Kampala, Uganda. Flisher, A.J. & Lund, C. 2000. Psychiatric service indicators in the RSA: III. Staff/population ratios. 11th National Psychiatry Conference (World Psychiatric Association Co-Sponsored Meeting), Durban. Flisher, A.J. & Lund, C. 2000. Psychiatric service indicators in the RSA: V. Community/hospital ratios. 11th National Psychiatry Conference (World Psychiatric Association Co-Sponsored Meeting), Durban. Flisher, A.J. & Lund, C. 2000. Psychiatric service indicators in the RSA: VII. Admission rates. 11th National Psychiatry Conference (World Psychiatric Association Co-Sponsored Meeting), Durban. Flisher, A.J. & Lund, C. 2000. Psychiatric service indicators in the RSA: IX. Default rates. 11th National Psychiatry Conference (World Psychiatric Association Co-Sponsored Meeting), Durban. Flisher, A.J., Lund, C., Muller, L., Dartnall, E., Lee, T., Porteus, K. & Robertson, B.A. 2000. Psychiatric service indicators in the RSA: I. Methodological issues. 11th National Psychiatry Conference (World Psychiatric Association Co-Sponsored Meeting), Durban, 2000.
172
Flisher, A.J., Lund, C., Porteus, K. & Lee, T. 2000. Psychiatric service norms in the RSA. 11th National Psychiatry Conference (World Psychiatric Association Co-Sponsored Meeting), Durban. Flisher, A.J., Lund, C., Porteus, K. & Lee, T. 2000. Psychiatric service norms in the RSA. Recent developments in South African Psychiatric Services. 11th National Psychiatry Conference (World Psychiatric Association Co-Sponsored Meeting), Durban. Flisher, A.J. & Meys, U. 2000. Obsessionality and compulsivity: adverse effects of methylphenidate in the treatment of attention deficit hyperactivity disorder. First International Southern African Conference on Attention Deficit Hyperactivity Disorder, Cape Town. Flisher, A.J., Muller, M., Lombard, C. & Parry, C. 2000. Stages of progression in adolescent substance use in Cape Town. Tenth World Congress of the International Committee for the Prevention of Alcohol and Drug Dependency, Cape Town. Flisher, A.J., Parry, C.D.H., Morojele, N.K., Muller, M. & Lombard, C. 2000. The South African Community Epidemiology Network on Drug Use (SACENDU): School Survey (Symposium). 9th International Conference on Treatement of Addictive Behaviours, Cape Town. Landman, M., Molteno, C., Cooper, P., Tomlinson, M., Swartz, L. & Murray, L. 2000. A case-control study of a prevention in Khayelitsha, Cape Town, South Africa. 12th International Conference on Infant Studies (ICIS 2000), Brighton, United Kingdom. Liang, H., Flisher, A.J. & Chalton, D.O. 2000. Violence and substance use in adolescents with increasing severity of suicidal behaviour. 2nd World Psychiatric Association and Ugandan Psychiatric Association Regional Psychiatric Conference, Kampala, Uganda. Lombard, C.J., Muller, M., Flisher, A.J. & Parry, C. 2000. The analysis of substance abuse in Cape Town adolescents. Annual Conference of the South African Statistical Association, Johannesburg. Lund, C. & Flisher, A.J. 2000. Psychiatric service indicators in the RSA: IV. Staff/bed and staff/patient ratios. 11th National Psychiatry Conference (World Psychiatric Association Co-Sponsored Meeting), Durban. Lund, C. & Flisher, A.J. 2000. Psychiatric service indicators in the RSA: VI. Bed/occupancy rates. 11th National Psychiatry Conference (World Psychiatric Association Co-Sponsored Meeting), Durban. Lund, C. & Flisher, A.J. 2000. Psychiatric service indicators in the RSA: VIII. Average length of stay. 11th National Psychiatry Conference (World Psychiatric Association Co-Sponsored Meeting), Durban. Lund, C., Flisher, A.J., Porteus, K. & Lee, T. 2000. Psychiatric service indicators in the RSA: II. Bed/population ratios. 11th National Psychiatry Conference (World Psychiatric Association Co- Sponsored Meeting), Durban. Malcolm, C. 2000. Models of post-conflict community reconciliation. Solomon Asch Centre for Study of Ethnopolitical Conflict Summer Conference, Philadelphia, Pennsylvania, USA. Malcolm, C. 2000. The impact of post-traumatic stress disorder (PTSD) on self-states. 5th Annual South African Self Psychology Conference, Cape Town. Malcolm, C. 2000. Towards a human-rights based ethical code for professional psychology in South Africa. Annual Psychological Society of South Africa Congress, Johannesburg. Malcolm, C. & Haupt P. 2000. Betweeen hell and hope: An organisational analysis of the Truth and Reconciliation Commission (TRC). 5th Annual Symposium of the International Society for the Psychoanalytic Study of Organizations, London, United Kingdom. Milby, J.B. & Ward, C.L. 2000. Interactive goal-setting in substance abuse treatment: writing and reviewing practical, strategic goals to increase motivation and enhance therapeutic response. 9th International Conference on Treatment of Addictive Behaviors, Cape Town. Molteno, C., Adnams, C., Hay, A., Croxford, J. & Viljoen, D. 2000. Behavioural problems in children with fetal alcohol syndrome in the Wellington district, South Africa. 11th World Congress of the International Association for the Scientific Study of Intellectual Disability, Seattle, Washington, U.S.A. Journal of Intellectual Disability Research 44:399. Molteno, C. & Kench, E. 2000. A distance learning course in intellectual disability. 11th World Congress of the International Association for the Scientific Study of Intellectual Disability, Seattle, Washington, U.S.A. Molteno, C. & Kench, E. 2000. Community outreach: distance learning programme for people with intellectual disability. Crossing the Boundaries Towards Quality Mental Health: Western Cape Psychosocial Rehabilitation Conference, Cape Town. Journal of Intellectual Disability Research 44:399. Molteno, G., Molteno, C. & Dawes, A. 2000. Behavioural and emotional problems in children with intellectual disability as assessed on the Develomentaal Behaviour Checklist – Teacher Version. 11th World Congress of the International Association for the Scientific Study of Intellectual Disability, Seattle, Washington, U.S.A. Journal of Intellectual Disability Research 44:399. 173
Molteno, C., Tomlinson, M., Cooper, P., Landman, M. & Swartz, L. 2000. Social adversity and postnatal depression in a peri-urban South African community. 7th World Conference of the World Association of Infant Mental Health, Montreal, Canada. Infant Mental Health 21:382. Morojele, N.K., Flisher, A.J., Muller, M., Ziervogel, C.F., Reddy, P. & Lombard, C. 2000. Adolescents, HIV and drug abuse. Meeting of the Global Research Network on HIV Prevention in Drug Abusing Populations, Durban. Morojele, N.K., Flisher, A.J. & Parry, C.D.H. 2000. Urbanisation, adolescents and substance use in South Africa. WHO meeting on Urbanisation, Youth and Substance Abuse, Kobe, Japan. Muller, M., Lombard, C.J., Flisher, A.J. & Parry, P. 2000. To see the "forest" and the "trees": event charts for smoking, alcohol and dagga. Annual Conference of the South African Statistical Association, Johannesburg. Peter, E.M. & Molteno, C.D. 2000. Inpatient management of dual diagnosis in intellectual disability – the Alexandra Hospital short term unit. 11th National Psychiatry Conference (World Psychiatric Association Co-Sponsored Meeting), Durban. Peter, E.M. & Molteno, C.D. 2000. A case study of long-term safety and efficacy of resperidone used in 20 children and adolescents with behavior disorders. 11th National Psychiatry Conference (World Psychiatric Association Co-Sponsored Meeting), Durban. Robertson, B., Zissis, C., Sauls, H., Meys, U. & Ackerman, T. 2000. The development of a risk model for youth who commit serious violent crime. 11th National Psychiatry Congress (World Psychiatric Association Co-Sponsored Meeting), Durban. Saunders, J. 2000. Neuropsychiatric aspects of HIV infection. 11th National Psychiatry Congress (World Psychiatric Association Co-Sponsored Meeting), Durban. Tomlinson, M., Molteno, C., Cooper, P. & Swartz, L. 2000. Postpartum depression, the mother-infant relationship, and child development in a South African peri-urban settlement. 12th International Conference on Infant Studies (ICIS 2000), Brighton, United Kingdom. Zissis, C. & Robertson, B. 2000. The effectiveness of a community mental health project in Khayelitsha: A model for cost-effective service provision. Concerted Action Workshop of the Concerted Action Project on Methods for Intervention on Mental Health in Sub-Saharan Africa, Cape Town. Zissis, C. 2000. Service Provision and Mental Health Promotion: The effectiveness of a community- based mental health project situated in the peri-urban settlement of Khayelitsha, South Africa. The Inaugural World Conference: The Promotion of Mental Health and Prevention of Mental and Behavioural Disorders, Atlanta, GA, U.S.A. Zabow, T. 2000. Advance directives: influence of the judicial and prison authorities on the clinical management of a detainee. 13th World Congress on Medical Law, Helsinki, Finland. Zabow, T. 2000. Follow up study of insanity-acquitees as psychiatric patients: protective detention, rehabiliation or recidivism risk? 13th World Congress on Medical Law, Helsinki, Finland. Zabow, T. 2000. Management of impaired doctors: ethical, legal and clinical issues. Imparied doctors conference of the Health Professions Council of South Africa, Cape Town. Zabow, T. 2000. The new mental health act: problems, progress and ethical dilemmas. 11th National Psychiatry Congress (World Psychiatric Association Co-Sponsored Meeting), Durban. Zabow, T. 2000. Outcome assessments of state patients’ rehabilitation. The new mental health act: problems, progress and ethical dilemmas. 11th National Psychiatry Congress (World Psychiatric Association Co-Sponsored Meeting), Durban.
DISSERTATION PASSED FOR HIGHER DEGREE
De Beer, J. 2000. Characteristics of students receiving mental health services at the University of Cape Town: 1-880. M.Sc. (Med.) Dissertation, University of Cape Town.
UNIVERSITY PUBLICATIONS AND PUBLICATIONS OF A POPULAR NATURE
Close, P., Joska, J. & Nassen, R. 2000. Approach to the acutely confused or behaviourally disturbed patient. Specialist Medicine 22: 456-470. Flisher, A.J. 2000. Attention deficit hyperactivity disorder in adults. Specialist Medicine 22: 472-476. Flisher, A.J. 2000. Bipolar disorder in children and adolescents. Specialist Medicine 22: 197-204. Flisher, A.J. 2000. Troublesome disguises (editorial). Specialist Medicine 22: 454.
174
UNPUBLISHED RESEARCH/TECHNICAL/POLICY DOCUMENTS
Abas, M., Blue, I., Chagwedere, I., Ekblad, S., Grant, E., Harpham, T., Haworth, A., Kordic, B., Kortmann, G., Mayeya, J., Robertson, B. & Zissis, C. 2000. EC Concerted Action Workshop Report: Methods for Interventions on Mental Health in sub-Saharan Africa. Report submitted to the European Commission. Cape Town, Department of Psychiatry, University of Cape Town, 1- 23. Abas, M., Blue, I., Chagwedere, I., Ekblad, S., Grant, E., Harpham, T., Haworth, A., Kordic, B., Kortmann, G., Mayeya, J., Robertson, B. & Zissis, C. 2000. Mental Health in sub-Saharan Africa: A briefing on the situation and its policy implications. Report submitted to the European Commission. London South Bank University, 1-4. Morojele, N.K., Saban, A., Flisher, A.J. & Parry, C.D.H. 2000. Urbanisation and risk factors for substance abuse among youth in South Africa: preliminary results of secondary data analyses. Report prepared for a WHO multi-site research project on Urbanisation, Adolescents and Risk Factors for Substance Abuse. Cape Town, Medical Research Council, 1-33. Robertson, B.A. 2000. National Mental Health Assessment. In Lesotho Health Study. Washington, DC: Medical Care Development International 5:1-5:27. Quinn, J., Zissis, C. & Robertson, B.A. 2000. An evaluation of psychiatric out patient services provided by Valkenberg and Groote Schuur Hospitals. Report submitted to Valkenberg and Groote Schuur Hospitals. Cape Town: Department of Psychiatry, University of Cape Town, 1-40.
CONSULTANCY AND OTHER ACTIVITIES BASED ON EXPERTISE DEVELOPED IN RESEARCH
Professor Brian Robertson Consultant, National Directorate: Mental Health and Substance Abuse for the development of Policy Guidelines for Child and Youth Mental Health Delegate, WHO Consultative Meeting on the Implementation of the Mental Health Regional Strategy and the Preparation of the World Mental Health Report 2001, Harare, Zimbabwe Director, Centre for the Study of Violence and Mental Health, Department of Psychiatry, University of Cape Town Member, Editorial Board of the Southern African Journal of child and Adolescent Mental Health Member, Evaluation Panel of the Mental Health and Substance Abuse Thrust of the Medical Research Council Mental Health Consultant, Medical Care Development International, Lesotho Health Sector Reform Study Associate Professor Tuviah Zabow Consultant, Department of Health Task Team, Mental Health Care Bill Consultant, Medical And Dental Board of the Health Professions Council of South Africa, Impaired Doctors and Students Associate Professor Alan Flisher Consultant, National Directorate: Child and Youth Health for the development of Policy Guidelines in Adolescent and Youth Health Consultant, National Directorate: Mental Health and Substance Abuse for the development of Policy Guidelines for Child and Youth Mental Health Consultant, World Health Organisation (WHO), to develop evidence-based guidelines on mental health service delivery Delegate, International Experts Meeting and Research Meeting of the National Adolescent-Friendly Clinic Initiative (NAFCI), Johannesburg Editor, Southern African Journal of Child and Adolescent Mental Health Member, Editorial Advisory Board, African Journal of Substance Abuse Member, Editorial Board, South African Journal of Psychiatry Member, International Steering Committee of the European Commission-funded Adolescent Reproductive Health Network Member, Provincial Council, Planned Parenthood Association of South Africa (Western Cape) Member, Review Panel, Medical Research Council Member, Youth AIDS Project Board of Advisors Referee/reviewer, Archives of Paediatrics and Adolescent Medicine, Journal of Adolescence, Medical Research Council, National Research Foundation, South African Journal of Psychiatry, South African Medical Journal Temporary Advisor, WHO and United Nations Children’s Fund (UNICEF), for the project “Programming for Adolescent Health and Development: What Should We Measure and How” 175
Dr Charles Malcolm Post-Doctoral Research Associate, Solomon Asch Centre for the Study of Conflict, University of Pennsylvania, Philadelphia Consultant, National Institute for Criminal Rehabilitation and Offending (NICRO) Affiliate, Centre of Investigative Psychology, Rhodes University, Grahamstown. Mr Chris Zissis Convenor, EC Concerted Action Project Workshop: Methods for Interventions on Mental Health in sub- Saharan Africa. Cape Town: 28 to 31 March 2000. Facilitator (with Cathy Ward), Bonnytoun Place of Safety, Support Consultation and Training Programme: January - November 2000. Participant member of the Africa Region Meeting on Analytical Studies on Mental Health Policy and Services , International Consortium for Mental Health Policy and Services.
176
DEPARTMENT OF PUBLIC HEALTH (Including the Health Economics Unit, the Occupational and Environmental Health Research Unit, and the Women’s Health Research Unit)
HEAD OF DEPARTMENT - Professor Jonny Myers
DEPARTMENTAL CONTACT DETAILS
Postal address: Department of Public Health Health Sciences Faculty Anzio Road Observatory 7925 South Africa Telephone: SA (21) 406-6300/6306 Fax: SA (21) 406-6163 e-mail: [email protected] web-page: http://www.uct.ac.za/depts/cmh/chealth.htm
DEPARTMENTAL PROFILE
The Department of Public Health aims to study the health of the population and measures to improve health, by undertaking research in the following areas: • primary health care (Mamre and Zibonele projects); • epidemiology, vital statistics, surveillance and communicable diseases – especially HIV/AIDS; • health economics and policy; • occupational and environmental health, and • women’s health. These studies involve multidisciplinary expertise including epidemiology, biostatistics, social and behavioural sciences, health economics, management and policy analysis, and clinical decision-making. There is collaboration with UCT Departments, particularly the Department of Primary Health Care, SHAWCO, and with other research and service organisations, both nationally and internationally appropriate research is conducted in a community participatory manner.
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG TERM CONTRACT STAFF
UNIVERSITY STAFF PAWC STAFF Associate Professors 2 Senior Specialist/Associate 3 Senior Lecturer/Medical Specialist 1 Professors Chief Research Officers 2 Senior Specialists /Senior lecturers 1 Senior Research Officers 5 Specialist Scientist 1 Research Officers 23 Admin & Clerical Staff 1 Community Health Workers 26 TOTAL 6 Technical Support Staff 1 Admin & Clerical Staff 7 JMS STAFF Departmental Assistants 2 Professors 1 TOTAL 69 TOTAL 1
TOTAL: 76
177
HONORARY STAFF STUDENTS
Honorary lecturers 3 Doctoral 9 TOTAL 3 Masters 29 Registrars 7 Undergraduate 165 TOTAL 210
RESEARCH FIELDS
PERMANENT STAFF
Professor Jonny Myers Head of Department, Director, Occupational and Environmental Health Research Unit; Occupational health, epidemiology Associate Professor Margaret Hoffman Director, Womens Health Research Unit; Women’s and reproductive health; community based research/projects Associate Professor Leslie London Associate Director: Occupational and environmental health research unit, Occupational and environmental health; pesticide policy and safety; AIDS prevention and control; primary health care service development; human rights Associate Professor Diane McIntyre Director: Health Economics Unit; Health economics, health care financing, health expenditure; resource allocation; equity and health Associate Professor Mary-Lou Thompson Biostatistics; occupational and environmental health; women’s health Dr Nicol Coetzee Prevention and control of communicable diseases; epidemiology methodology; health systems research; health informatics Associate Professor Rodney Ehrlich Asthma, occupational and childhood; Lead: occupational effects; Lead effects, regulation; High risk work: isocyanates, construction, asbestos; Tobacco: disease trends, environmental tobacco smoke; Medical surveillance; compensation policy Mr Rauf Sayed Biostatistical Support; birth defects surveillance; analysis of mortality and health; health information studies Dr Helen de Pinho Oliver Tambo fellowship co-ordinator; Health Management; Medical education
CONTRACT RESEARCH STAFF
Mr David Bourne birth defects surveillance; health informatics; vital statistics Dr Mohamed Jeebhay occupational allergy and asthma; exposure assessment methods for bioaerosols (grain, storage pests, seafood); occupational health of mineworkers and foodworkers; occupational health services; health and safety policy and legislation Ms Spindele Magwaza Quality control; STD services; women’s health; violence Ms Cathy Mathews HIV prevention; health systems research; women’s health Dr Diane Cooper Associate Director: Women’s Health Research Unit - women’s and reproductive health; social determinants of women’s health; breast cancer; cervical cancer and contraception Mr Stephen Thomas health economics and financing; evaluation of health care reform Ms Veloshnee Govender health economics Ms Andrea Rother pesticide policy research 178
Mr Aqiel Dalvie occupational and environmental health Ms Chantelle Henn occupational and environmental health Ms Edina Sinanovic health economics Ms Charlotte Muheki health economics Dr Jennifer Moodley women’s health research Ms Alana de Kock HIV/STD research Ms Motlagonang Maruping Pesticides and health research Mr Joseph Molekwa occupational allergy and asthma Ms Phyllis Orner Women’s health research
DISTINGUISHED VISITORS
Professor L Rosenberg Slone Epidemiology Unit, Boston University, United States of America Dean Merson School of Public Health, Yale University Professor C Normand London School of Hygiene and Tropical Medicine Professor A Mills London School of Hygiene and Tropical Medicine Professor Gavin Mooney University of Sydney Professor Samuel Shapiro Slone Epidemiology Unit, Boston University, United States of America Professory Lesley Doyal School for Policy Studies, University of Bristol, United Kingdom Professor Sally Guttmacher Department of Health Studies, New York University
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Baldwin-Ragavan, L., London, L. & de Gruchy, J. 2000. Learning from our apartheid past: Human rights challenges for health professionals in contemporary South Africa. Ethnicity and Health 5: 227-241. Buck, R., Miles, A. & Ehrlich, R. 2000. Possible occupational asthma among adults presenting with acute asthma. South African Medical Journal 90:884-888. Ehrlich, R.I. 2000. Occupational disease gap. (letter) South African Medical Journal: 567. Govender, M., Ehrlich, R.I. & Mohammed, A. 2000. Notification of occupational diseases by general practitioners in the Western Cape. South African Medical Journal 90:1012-1014. Hoffman, M., de Pinho, H., Cooper, D., Sayed, R., Dent, D.M., Gudgeon, A., van Zyl, J., Rosenberg, L. & Shapiro, S. 2000. Breast Cancer incidence and determinants of cancer stage in the Western Cape. South African Medical Journal 90: 1212-1216. Jeebhay, M.F., Lopata, A.L. & Robins, T.G. 2000. Seafood processing in South Africa: a study of working practices, occupational health services and allergic health problems in the industry. Occupational Medicine 50:406-413. Jeebhay, M. 2000. Occupational Allergy: a focus on biological agents (editorial). Current Allergy and Clinical Immunology 13(3): 2-3. Jeebhay, M.F. 2000. Health and safety legislation and worker’s compensation for allergic diseases of occupational aetiology. Current Allergy and Clinical Immunology 13(3): 4-8. Jeebhay, M.F., Robins, T. & Lopata, A.L. 2000. Occupational seafood allergy. Current Allergy and Clinical Immunology 13(3): 20-22.
179
Jeebhay, M.F., Stark, J., Fourie, A., Robins, T. & Ehrlich, R. 2000. Grain dust allergy and asthma among grain mill workers in Cape Town. Current Allergy and Clinical Immunology 13(3): 23- 32. London, L., Thompson, M.L., Capper, W. & Myers, J.E. 2000. Utility of vibration sense testing for use in developing countries: Comparison of extinction time on the tuning fork to vibration thresholds on thee Vibratron II. Neuro Toxicology 21: 743-752. Lopata, A., Fenemore, B., Majova, Z., Bali, N. & Jeebhay, M. 2000. Insect and storage pests causing occupational allergy. Current Allergy and Clinical Immunology 13(3): 16-19. Killingsworth, J., Hossain, N., Hedrick-Wong, Y., Thomas, S., Rahman, A. & Begum, T. 1999. Unofficial fees in Bangladesh: price, equity and institutional issues. Health Policy and Planning 14(2): 152-163. London, L. 2000. Alcohol consumption amongst South African farm workers: a challenge for post apartheid health sector transformation. Drug and Alcohol Dependence 59:199-206. Mash, R.J., Coetzee, N., Patel, S. & Heywood, A. 2000. The Tuberculosis Register - An evaluation of its use and impact under epidemic conditions in the Western Cape Province of South Africa. South African Family Practice 22:9-14. Rother, H-A. 2000. Influences of pesticide risk perception on the health of rural South African women and children. African Newsletter on Occupational Health and Safety 10:42-46. Shapiro, S., Rosenberg, L., Hoffman, M., Truter, H., Cooper, D., Rao, S., Dent, D., Gudgeon, A., van Zyl, J., Katzenellenbogen, J. & Bailie, R. 2000. Risk of breast cancer in relation to the use of injectable contraceptives and combined estrogen/progestogen contraceptives. American Journal of Epidemiology 151:396-403. Tolosana, S. & Ehrlich, R. 2000. Characteristics of liquid effluent from medical institutions in Cape Town. South African Journal of Science 96:417-420.
CHAPTERS IN BOOKS
Kisting, S. 1999. Occupational and Environmental health and Safety for Women Farm workers in South Africa. In Wyman, M. (ed.) Sweeping the Earth. Women Taking Action for a Healthy Planet: 162-171. Canada: Gynergy Books. Coetzee, N., Mathews, C., Zwarenstein, M. & Guttmacher, S. 2000. Partner notification: Sexual Health. In Godlee, F., Baton, S. & Donald, A. (eds) Clinical Evidence Issue 3: 781-787. BMJ Publishing Group. McIntyre, D., Thomas, S., Mbatsha, S. & Baba, L. 1999. Equity in public sector health care financing and expenditure in South Africa. In Crisp, N. & Ntuli, A. (eds) South African Health Review 27: 52. Durban: Health Systems Trust. Jeebhay, M. & Jacobs, B. 1999. Occupational health services in South Africa. In Crisp, N. & Ntuli, A. (eds) South African Health Review, 5th edition 19: 257-276. Durban: Health Systems Trust. http://www.hst.org.za/sahr/99/chap19.htm
THESES AND DISSERTATIONS PASSED FOR HIGHER DEGREES
Oosthuizen, J. de V. 2000. An assessment of the extent of environmental mercury contamination in the vicinity of Thor Chemicals, Cato Ridge, KwaZulu-Natal and the subsequent health risk for communities consuming fish in the area: 1-116. Ph.D. thesis, University of Cape Town. Patel, N. 2000. Organised care of acute stroke at Groote Schuur Hospital: 1-114. M.Phil dissertation, University of Cape Town.
UNIVERSITY PUBLICATIONS AND PUBLICATIONS OF A POPULAR NATURE
Andrews, A., Kisting, S., Jeebhay, M. F., Maharaj, R., Henwood, N., Omar, F. & Isaacs, S. 2000. Comments on the Draft Amended Asbestos Regulations (Technical Report). Legal Resources Centre, Industrial Health Research Group (UCT), Occupational and Environmental Health Research Unit (UCT), Industrial Health Unit (UND): 1-7. Dorrington, R., Bradshaw, D., Bourne, D. & Karim, S.A. 2000. Reply to 1999 HIV surveillance result – little grounds for pessimism. (Letter). South African Medical Journal 90:1062-1064. Ehrlich, R.I. 2000. The Occupational Health and Safety Act, the regulations for hazardous chemical substances and what every doctor needs to know about preventive mechanisms in occupational health. South African Respiratory Journal 5:128-130. Ehrlich, R.I. 2000. The epidemiology of occupational asthma in South Africa and some problems in diagnosing occupational asthma. South African Respiratory Journal 6:10-12.
180
Jeebhay, M.F. 2000. Comments on the pilot exercise on the development of occupational health services in the North West Province. (Technical Report) Occupational and Environmental Health Research Unit (UCT): 1-7. Jeebhay, M.F. & Lopata, A.L. 2000. Comments on the draft regulations for hazardous biological substances. (Technical Report). Occupational and Environmental Health Research Unit (UCT) and Allergology Unit (UCT/Groote Schuur): 1-9. Kisting, S., Jeebhay, M., Lewis, P., Edwards-Abdullah, D., Mbuli, S., Henwood, N., Adams, S. & Cairncross, L. 2000. An introduction to occupational and environmental health and safety for health care providers. Resource manual used in the training of health care workers: 1-200. Industrial Health Research Group. London, L., Hussey, G. & Keen, A. 2000. HIV and AIDS – open letter to the President of South Africa and the Minister of Health. (Letter.) South African Medical Journal 90:444. London, L. 2000. Postmodernism, the law and ethical dilemmas. (Letter). South African Medical Journal 90: 830-831. London, L., Dalvie, M.A., Cairncross, E. & Solomons, A. 2000. The quality of surface and groundwater in the rural Western Cape with regard to pesticides. Final report to the Water Research Commission on the Project “An assessment of the quality of water supplies in the rural Western Cape with regard to agrichemical pollutants.” WRC Report Number K5/795”. Water Research Commission, Pretoria: 1-160. Young, T. & Coetzee, N. 2000. Technical Report: Monitoring methodology used in the Khayeltisha mother-to-child HIV transmission prevention programme. Department of Public Health, University of Cape Town: 1-36.
CONSULTANCY AND OTHER ACTIVITIES BASED ON EXPERTISE DEVELOPED IN RESEARCH
Professor Jonny Myers was appointed to the National Advisory Council on Occupational Health by the Minister of Labour. He was also appointed as an Advisor to the Compensation Commissioner (COIDA) on occupational diseases. He was elected Chairperson of the Division of Occupational Medicine of the College of Public health Medicine of the Colleges of Medicine of South Africa. He is a member of the Scientific Committee for the 8th International Symposium of Neurobeh joural Methods and Effects in Occupational and Environmental Health. He facilitated the review of the strategic plan of the Free State Department of Health in 2000. He advised the legal representative of environmental groupings on issues related to SASOL adding organic manganese (MMT) into petrol in October 2000. Associate Professor Leslie London is a Board Member for the Trauma Centre for Survivors of Violence and Torture, Cape Town and the of the Health Systems Trust, Durban. He was nominated to the Interim National Research Ethics Committee of the Department of Health in 2000 and also serves as Vice-chairperson of the Advisory Committee on Human Rights, Ethics and Professional Practice for the Medical and Dental Board of the Health Professions Council of South Africa. He is a member of the Public Advisory Panel on Responsible Care to the Chemical and Allied Industries Association (CAIA), and serves as a consultant to Pesticides Research Group at the National Centre for Occupational and Environmental Health, to the AIDS Law Project in Johannesburg in cases involving discrimination against people with HIV, and as an International Medical Advisor to the Samhavna Clinic, Bhopal, India. Associate Professor London also serves on the South African Liaison Committee for the University of Michigan Fogarty Project. Associate Professor Margaret Hoffman is a member of the Western Cape Reproductive Health Advisory Committee and a member of the Executive Committee Planned Parenthood Association of South Africa Western Cape Region Branch. Is a committee member of the Medical Research Council, Evaluation panel for the Women’s Health. An Editorial Advisory Board Member for the African Journal of Reproductive Health and a member of the Joint Primary Health Care Programme Trust. Dr Nicol Coetzee serves on the Barrier Methods (HIV/AIDS Prevention) Task Force, National Department of Health; the Editorial Advisory Board for the Journal of Epidemiology and Community Health; and the ad hoc Ministerial Advisory Committee (Western Cape) on HIV prevention (Mother-to-child transmission and post-rape prophylaxis). Mr David Bourne is a member of the National Health Information System Committee of the Department of Health , Western Cape. He is a member of the International Standards Organization Technical Committee on Health, Working Group 3, Health Concept Representation, and the SA Bureau of Standards subcommittee SC71D on Health Informatics. He is a consultant to the MRC's Burden of Disease Unit and Health Informatics R&D group, and a member of the International Clearinghouse on Birth Defects Monitoring Systems. 181
Dr Diane Cooper is a member of the Advisory Committee appointed by the Department of National Health to formulate a framework and guidelines for contraceptive services in South Africa; a member of the International Review Committee, Global Action Plan, World Conference on Breast Cancer, Kingston, Canada. Is a member of the Planned Parenthood Association’s Community based Reproductive Health Programme Advisory Committee in the Western Cape. Is a Trustee on the Board of the Participatory Primary Health Care Programme, a European Union funded non-Governmental community-based health initiative. Dr Mohamed Jeebhay has been appointed as consultant to the research and development team of "Soul City - Series 6", the national television and radio health promotion programme, which will focus on work-related asthma as one of its major themes.
182
DEPARTMENT OF RADIATION ONCOLOGY
HEAD OF DEPARTMENT - Professor I D Werner
DEPARTMENT CONTACT DETAILS
Postal address: Department of Radiation Oncology Groote Schuur Hospital & University of Cape Town Observatory 7925 South Africa Telephone: SA (21) 404-4263/5 Fax: SA (21) 404-5259 e-mail: [email protected]
DEPARTMENTAL PROFILE
1. The Department of Radiation Oncology provides the following services: 1.1 Investigation, management and treatment of all forms of malignant disease referred from within Groote Schuur Hospital, other academic hospitals and the private medical community both within the borders of the country and from neighbouring countries. 1.2 Participation in drug-related clinical studies, both national and international. 1.3 Maintenance of cancer registries monitoring cancer incidences and epidemiological characteristics. 1.4 National referral treatment centre for retinoblastoma and ocular malignant melanoma
2. Provision of cancer services to the satellite academic departments of Provincial Hospital, Port Elizabeth and Frere Hospital, East London.
3. Development of national referral centre for proton and neutron beam radiotherapy in conjunction with the Department of Radiation Oncology, Tygerberg Hospital, University of Stellenbosch and the National Accelerator Centre, Faure. Development of stereo-photogrammetric patient positioning system for the delivery of proton therapy beams in collaboration with Departments of Engineering and Land Surveying at UCT.
4. Teaching of undergraduate medical courses and provisional of post graduate specialists training courses. Pre and post-diplomate instruction to radiographers and post-diplomate courses to nurses. Full training in Radiobiology from under-graduate to honours, masters and doctoral level.
5. Provision of a comprehensive clinical radiobiological research facility.
DEPARMENTAL STATISTICS 2000
PERMANENT AND LONG TERM CONTRACT STAFF
UNIVERSITY STAFF JOINT STAFF (UCT/PAWC) Research Staff 5 Associate Professors 1 Administrative 1 Professor of Radiation 1 and Clerical Staff Oncology SUBTOTAL 6 Senior full-time Lecturers 4
Senior part-time Lecturers 2
Lecturers 2 JMS STAFF
Principal Medical Officers 1 Professors 1
SUBTOTAL 1 Sessional Medical Officers 3 Technical Support Staff 2 SUBTOTAL 16 TOTAL: 23 183
HONORARY STAFF STUDENTS
Honorary Lecturers 3 Registrars 11 TOTAL 3 Masters of Medicine 1 Doctoral (Radiobiology) 2 TOTAL 14
RESEARCH FIELDS
PERMANENT STAFF
Professor Dudley Werner Chief Specialist Radiation Oncology & Head of Department; Breast Cancer/Paediatric Malignancies Professor Raymond Abratt Professor of Radiation Oncology, Principal Specialist & Senior Lecturer; Lung Cancer; Male Genito-urinary Tract Cancer Assoc./Professor Gerry Blekkenhorst Associate Professor, Senior Lecturer and Section Head of Radiobiology; Medical Natural Science and Radiobiology (research on tumours with experimental animals)
Specialist Staff
Dr Christina Geddes Senior Specialist Radiation Oncology & Senior Lecturer; Thyroid, Oesophageal and Gastro- intestinal cancers Dr Dorothea Kranold Part-time Senior Specialist Radiation Oncology & Senior Lecturer; Tumours of the ear, nose & throat, Head & Neck Cancer, Sarcomas Dr Elizabeth Murray Senior Specialist Radiation Oncology & Senior Lecturer; Breast Cancer Dr Clare Stannard Senior Specialist Radiation Oncology & Senior Lecturer; Head & Neck Cancer, Tumours of the Eye, Neutron & Proton Therapy Dr Helen Stubbings Specialist Radiation Oncology & Lecturer; Lymphoma, Myeloma, Leukaemia Dr Leon Van Wijk Senior Specialist Radiation Oncology & Senior Lecturer; Gynaecological tumours Dr Jenni Wilson Part-time Specialist Radiation Oncology & Lecturer; Proton therapy; Neutron therapy; Neuro- oncology
Medical Officers
Dr Cindy Shepherd Principal Medical Officer Radiation Oncology; Main interests - Lung cancer, Tumours of the thyroid, Male genito-urinary tract cancer.
Scientific Staff
Dr Andre Hendrikse Senior Medical Natural Scientist & Lecturer; Research in Medical Natural Science Radiobiology (research on tumours with experimental animals) Dr Alistair Hunter Medical Natural Scientist; Research in Medical Natural Science Radiobiology (research on tumours with experimental animals)
184
CONTRACT RESEARCH STAFF
Part-time Clerical Research Assistants (data managers) Mrs Jackie Duncan-Smith Data manager for Dr Johnson; Myeloma, Melanoma, Lymphoma, Leukaemia Mrs Sue Giles Data manager for Professor Werner and Dr Murray; Breast Cancer Mrs E McEvoy Data manager for Professor Werner and Dr Murray; Breast Cancer Mrs N Nedev Data manager for Professor Werner and Dr Murray; Breast Cancer Mrs Jean Wilmot Data manager for Professor R Abratt; Lung Cancer, Male Genito-urinary Tract Cancer
HONORARY LECTURERS
Dr R Christians Senior Specialist Radiation Oncology, Provincial Hospital, Port Elizabeth; Clinical participation in multidisciplinary clinics for full spectrum of malignant disease; participant in national & international cancer related drug research studies; postgraduate lecturer in Radiation Oncology Dr V Reddi Principal Specialist Radiation Oncology, Frere Hospital, East London; Clinical participation in multidisciplinary clinics for full spectrum of malignant disease; participant in national & international cancer related drug research studies; postgraduate lecturer in Radiation Oncology Professor G R H Sealy Emeritous Professor/ Specialist Radiation Oncology
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Hendrikse, A.S., Hunter, A.J., Keraan, M. & Blekkenhorst, G.H. 2000. Effects of low dose irradiation on TK6 and U937 cells: Induction of p53 and its role in cell-cycle delay and the adaptive response. International Journal of Radiation Biology 76: 11-21. Aebi, S., Gelber, S., Castiglione-Gertsch, M., Gelber, R.D., Collins, J., Thürlimann, B., Rudenstam, C- M., Lindtner, J., Veronesi, A., Cortes-Funes, H., Simonici, E., Werner, I.D., Coates, A.S. & Goldhirsch, A. for the International Breast Cancer Study Group (IBCSG). 2000. Is chemotherapy alone adequate for young women with oestrogen-receptor-positive breast cancer? Lancet 355: 1869-1874. Stannard, C.E., Sealy, G.R.H., Hering, E.R., Pereira, S.B., Knowles, R. & Hill, J.C. 2000. Malignant melanoma of the eyelid and palpebral conjunctiva treated with iodine-125 brachytherapy. Ophthalmology 107: 951-958. Rahbeeni, F., Hendrikse, A.S., Smuts, C.M., Gelderblom, W.C.A., Abel, S. & Blekkenhorst, G. 2000. The effect of evening primrose oil on the radiation response and blood flow of mouse normal and tumour tissue. International Journal of Radiation Biology 76: 871-877. Shepherd, F.A., Abratt, R.P., Crino, L., Green, M., Sandler, A., Steward, W., Iglesias, J. & Anglin, G. 2000. The influence of gemcitabine and cisplatin schedule on response and survival in advanced non-small cell lung cancer. Lung Cancer 30: 117-125.
CONFERENCE ABSTRACTS
International Conferences
Abratt, R.P. 2000. Clinical Modelling – Lung Cancer. 1st International Congress On Translational Research. Lugano, Switzerland. Abratt, R.P. November 2000. 4th International Alexandria Oncology Conference and ESO Course Current Phase III studies in Non Small Cell Lung Cancer, Alexandria. Stannard, C. 2000. Neutron Therapy at the National Accelerator Centre. 1st International Congress of the South African Radiobiology Society, Stellenbosch, Cape Town.
185
National Conferences
Abratt, R.P. 2000. A pilot study of mixed beam therapy for prostate cancer. SASMO / SASRO Conference, Pretoria. Abratt, R.P. 2000. Neo adjuvant chemotherapy for invasive bladder cancer. SASMO / SASRO Conference, Pretoria. Abratt, R.P. 2000. Clinical Research in developing Countries – Ethical Dilemmas Grand Round – Groote Schuur Hospital, Cape Town. Stannard, C. 2000. Retinoblastoma management. Ophthalmological Society of South Africa (OSSA) Congress, Swaziland.
UNIVERSITY PUBLICATIONS AND WORKS OF A POPULAR NATURE
Werner, I.D. 2000. Editorial. Understanding Oncology 11: 1. Hunter, A.J. 2000. The use of linear-quadratic model to determine equivalence of different fractionated protocols in radiotherapy: comparison of isoeffective doses at 2 Gy per fraction. Understanding Oncology 11: 4-5. Hendrikse, A. 2000. The potential for achieving therapeutic gain using therapy. Understanding Oncology 11: 19-20. Abratt, R.P. 2000. Letter - Clinical dose volume histograms and lung toxicity after irradiation for lung cancer. International Journal of Radiation Oncology, Biology, Physics 47: 1460.
CONSULTANCIES BASED ON EXPERTISE DEVELOPED IN RESEARCH
Abratt, R.P. 2000. Combined Modality Treatment of Lung Cancer. CME Course – Medical Societies of Philippines, Singapore and Korea. Werner, I.D. 2000. Regional (AFRA) Training Course on Radiotherapeutic Management of Paediatric Tumours, Cairo, Egypt. Abratt, R.P. 2000. Non surgical treatment of Non-Small Cell Lung Cancer. CME Lectures – Tokyo, Nagano and Niigita.
186
DEPARTMENT OF RADIOLOGY
HEAD OF DEPARTMENT - Professor Stephen James Beningfield
DEPARTMENTAL CONTACT DETAILS
Postal Address: Department of Radiology C16, Groote Schuur Hospital Private Bag Observatory 7935 South Africa Telephone: SA (21) 404-4184 or (21) 406-6426 Fax: SA (21) 404-4185 email: [email protected]
DEPARTMENTAL PROFILE
The Department of Radiology encompasses sub-departments in Groote Schuur Hospital, Red Cross Children's Hospital and Somerset Hospital. There is also departmental activity in GF Jooste, Conradie and Victoria Hospitals. Diverse multidisciplinary units include neuroradiology, thoracic, interventional, head and neck, hepatobiliary, vascular, trauma, urological and abdominal radiology. These all have service and collaborative research commitments. A number of trials in conjunction with Radiation Oncology, Medicine, Surgery and other departments are on-going. A joint trial evaluating the clinical utility of a new type of digital x-ray machine with other UCT departments and private industry is progressing. Teleradiology is also being evaluated in projects under way at present.
During this year, the department has lost a number of staff to overseas institutions and private practice, which has resulted in a loss of experienced personnel. One registrar also died tragically in a car accident earlier in the year.
DEPARTMENTAL STATISTICS 2000
UNIVERSITY STAFF JMS STAFF Professor and HOD 1 Associate Professor 1 Administrative Staff 1 Senior Lecturers 5 TOTAL 2 Lecturers 2 TOTAL 8
PART-TIME UCT STAFF PART-TIME JMS STAFF Film Librarian 1 Professor 1 TOTAL 1 Emeritus Professor 1 Senior Specialists 2 Lecturer 1 TOTAL 5
STUDENTS Masters (Registrars) 24 Masters (Subsidised 4 Registrars) TOTAL 28
187
RESEARCH FIELDS
Dr Seymour Atlas Gastrointestinal; vascular; interventive radiology; paediatric radiology Professor Stephen Beningfield Hepatobiliary; vascular; interventive radiology; computer applications and digital radiology Dr Savvas Andronikou Paediatric radiology Dr Helen Ball Ultrasound; mammography; computerised tomography and urological radiology Dr R Fisher Paediatric radiology Dr Minnie Garb Head and neck radiology; ear nose and throat imaging Dr Hillel Goodman Chest radiology; high-resolution computerised tomography and fine needle biopsies Professor Leonard Handler Neuroradiology Professor Ronald Kottler Mammography; gastrointestinal radiology Dr Elizabeth Lazarus Vascular; interventive radiology; ultrasound Dr Kamila Padia General radiology; ultrasound Dr Trevor Roman Computerised tomography and ultrasound Dr Robert Seggie Ultrasound; computerised tomography and musculo-skeletal radiology Dr Peter Steward Vascular; interventive radiology; ultrasound Dr Althea van Zyl Ultrasound; obstetrics and gynaecology; general radiology Dr Christopher Young Swallowing pathology; gastrointestinal radiology; general radiology
DISTINGUISHED VISITORS
Dr David Asinger Musculo-skeletal radiology Professor Michael Forsting University of Essen, Germany; Magnetic resonance Dr Mary Paul Colgan St James Hospital, Dublin, Ireland; Vascular imaging Dr Lawrence Friedman Canada; Ultrasound of shoulder pathology Dr Martin P Sandler Chairman Radiology Department, Vanderbilt University School of Medicine, Nashville, Tennessee, U.S.A.; PET and SPECT Mr John Postelmans MRI Business Management, Philips International, Holland; Magnetic resonance Inspector Koos Pieterse South African Police; Bullets and projectiles
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Corr, P., Couper, I., Beningfield, S.J. & Mars, M. 2000. A simple telemedicine system using a digital camera. Journal of Telemedicine and Telecare 6: 233-236. Meinert, D. & Mohammed, Z. 2000. MRI of congenital coronary artery aneurysm [case report]. The British Journal of Radiology 3: 322-324. 188
Sperryn, C.W., Beningfield, S.J. & Immelman, E.J. 2000. Functional entrapment of the popliteal artery. Australasian Radiology 44(1): 121-124.
CONFERENCE ABSTRACTS
Andronikou, S., McCulloch, M. & Goddard, E. 2000. The angiographic features of 21 South African children with Takayasu’s aortitis (non-specific aortoarteritis). Abstract of paper presented at the European Society of Pediatric Radiology, 37th Annual Congress, Lisbon, Portugal. Pediatric Radiology 30: B26. Andronikou, S., Kader, E. & McCulloch, M. 2000. Imaging strategy for African children with first diagnosed UTI in tertiary hospital setting. Abstract of poster presented at European Society of Pediatric Radiology, 37th Annual Congress, Lisbon, Portugal. Pediatric Radiology 30: B32. Andronikou, S., Kader, E. & Welman, C. 2000. Standardized ultrasound technique in evaluation of UTI in children. Abstract of poster presented at European Society of Pediatric Radiology, 37th Annual Congress, Lisbon, Portugal. Pediatric Radiology 30: B33. Andronikou, S., Welman, C. & Kader, E. 2000. The radiological features of abdominal tuberculosis as seen on CT scanning. Abstract of poster presented at European Society of Pediatric Radiology, 37th Annual Congress, Lisbon, Portugal. Pediatric Radiology 30: B38. Andronikou, S., Welman, C. & Kader, E. 2000. Periosteal reactions in children. Abstract of poster presented at European Society of Pediatric Radiology, 37th Annual Congress, Lisbon, Portugal. Pediatric Radiology 30: B41. Andronikou, S. 2000. MRI features of intracranial tuberculosis in children. Abstract of poster presented at European Society of Pediatric Radiology, 37th Annual Congress, Lisbon, Portugal. Pediatric Radiology 30: B45. Andronikou, S. & Kader, E. 2000. Intracranial ring enhancing lesions in African children. Abstract of poster presented at European Society of Pediatric Radiology, 37th Annual Congress, Lisbon, Portugal. Pediatric Radiology 30: B45. Andronikou, S., McCulloch, M. & Goddard, E. 2000. The angiographic features of 21 South African children with Takayasu’s aortitis (non-specific aortoarteritis). Paper presented at the European Society of Pediatric radiology, 37th Annual Congress, Lisbon, Portugal. Andronikou, S., Kader, E. & McCulloch, M. 2000. Imaging strategy for African children with first diagnosed UTI in tertiary hospital setting. Poster presented at European Society of Pediatric Radiology, 37th Annual Congress, Lisbon, Portugal. Andronikou, S., Kader, E. & Welman, C. 2000. Standardized ultrasound technique in evaluation of UTI in children. Poster presented at European Society of Pediatric Radiology, 37th Annual Congress, Lisbon, Portugal. Andronikou, S., Welman, C. & Kader, E. 2000. The radiological features of abdominal tuberculosis as seen on CT scanning. Poster presented at European Society of Pediatric Radiology, 37th Annual Congress, Lisbon, Portugal. Andronikou, S., Welman, C. & Kader, E. 2000. Periosteal reactions in children. Poster presented at European Society of Pediatric Radiology, 37th Annual Congress, Lisbon, Portugal. Andronikou, S. 2000. MRI features of intracranial tuberculosis in children. Poster presented at European Society of Pediatric Radiology, 37th Annual Congress, Lisbon, Portugal. Andronikou, S. & Kader, E. 2000. Intracranial ring enhancing lesions in African children. Poster presented at European Society of Pediatric Radiology, 37th Annual Congress, Lisbon, Portugal. Andronikou, S., Kader, E. & McCulloch, M. 2000. Imaging strategy for African children with first diagnosed UTI in tertiary hospital setting. Poster presented at Imaging in the New Millenium, CSIR Conference Centre, Pretoria. Andronikou, S., Kader, E. & Welman, C. 2000. Standardized ultrasound technique in evaluation of UTI in children. Poster presented at Imaging in the New Millenium, CSIR Conference Centre, Pretoria. Andronikou, S., Welman, C., Kader, E. & Beningfield, S.J. 2000. Abdominal tuberculosis in children: The radiological features as seen on CT scanning. Paper presented at Imaging in the New Millenium, CSIR Conference Centre, Pretoria. Andronikou, S. 2000. MRI features of intracranial tuberculosis in children. Poster presented at Imaging in the New Millenium, CSIR Conference Centre, Pretoria. Andronikou, S. & Kader, E. 2000. Intracranial ring enhancing lesions in African children. Poster presented at Imaging in the New Millenium, CSIR Conference Centre, Pretoria. Andronikou, S. & Atlas, S. 2000. Spinal dysraphism. Schering MRI Roadshow 2000, E Floor Lecture Theatre, New Groote Schuur Hospital.
189
Andronikou, S., Welman, C. & Kader, E. 2000. Periosteal reactions in children. Poster presented at Institute of Child Health and University of Cape Town Research Day 2000, Institute for Child Health, Cape Town. Andronikou, S., Kader, E. & Welman, C. 2000. Standardized ultrasound technique in evaluation of UTI in children. Poster presented at Institute of Child Health and University of Cape Town Research Day 2000, Institute for Child Health, Cape Town. Beningfield, S.J. 2000. Digital Trauma Unit : A Groote Schuur Experience. Paper presented at Imaging in the New Millenium, CSIR Conference Centre, Pretoria. Beningfield, S.J. 2000. The role of radiological intervention in the Budd Chiari syndrome. Paper presented at Imaging in the New Millenium, CSIR Conference Centre, Pretoria. Beningfield, S.J. 2000. Radiology of a mass in the liver. Paper presented at Current Perspectives in the Study of Liver Disease, Sun City. Bertelsman, J. & Andronikou, S. 2000. CT scanning in paediatric blunt abdominal trauma. Poster presented at Society of Radiographers of South Africa 15th National Conference, Arthur’s Seat Hotel, Cape Town. Bertelsman, J. & Andronikou, S. 2000. CT scanning in paediatric blunt abdominal trauma. Poster presented at Institute of Child Health and University of Cape Town Research Day 2000, Institute for Child Health, Cape Town. Fisher, R. 2000. Radiographic appearances of the paediatric chest. Paper presented at Workshop on Pattern Recognition of the Chest, Groote Schuur Hospital. Kottler, R.E. 2000. The radiological assessment of the mammogram. Paper presented at Symposium on Breast Disease : Imaging in Diagnosis and Management, Peninsula Technikon. Kottler, R.E. 2000. Radiology of breast disease. Paper presented at Symposium on Breast Disease: Imaging in Diagnosis and Management, Peninsula Technikon. McMahon, C.L., Welman, C.J., Woods, D.W., Levitt, D.S. & Lambert, E.V. 2000. Determination of visceral adipose tissue in young adults using anthropometry and computerised tomography. Paper presented at the 6th Biennial Congress of the Association of Dietetics in South Africa and the 18th Biennial Congress of the Nutritional Society, Durban. McCulloch, M., Andronikou, S., Hoffman, E.B., Goddard, E. & Kahn, D. 2000. Avascular necrosis of the hip in paediatric renal transplant recipients. Paper presented at First Congress of the International Paediatric Transplant Association. McCulloch, M., Goddard, E., Sinclair, P., Andronikou, S., Lawrenson, J. & Millar, A.J.W. 2000. Diagnostic and therapeutic interventions in the management of Takayasu’s arteritis at Red Cross Children’s Hospital. Paper presented at Institute of Child Health and University of Cape Town Research Day 2000, Institute for Child Health, Cape Town. McCulloch, M., Andronikou, S., Hoffman, E.B., Goddard, E. & Kahn, D. 2000. Avascular necrosis of the hip in paediatric renal transplant recipients. Abstract of paper presented at First Congress of the International Paediatric Transplant Association, Venice, Italy. Pediatric Transplantation 4 (Suppl 2): 122. McMahon, C.L., Welman, C.J., Woods, D.W., Levitt, D.S. & Lambert, E.V. 2000. Determination of visceral adipose tissue in young adults using anthropometry and computerised tomography. Abstract of paper presented at the 6th Biennial Congress of the Association of Dietetics in South Africa and the 18th Biennial Congress of the Nutritional Society, Durban. South African Journal of Clinical Nutrition 13(3): 104. Mirza, K.M., Krige, J.E.J., Beningfield, S.J., Bornman, P.C., Cullis, S. & Terblanche, J. 2000. Long- term management of intrahepatic stones. Abstract of paper presented at the Association of Surgeons Congress, Port Elizabeth. South African Journal of Surgery Supplement 38(4): 17. Mirza, K.M., Krige, J.E.J., Beningfield, S.J., Bornman, P.C., Cullis, S. & Terblanche, J. 2000. Long- term management of intrahepatic stones. Paper presented at the Association of Surgeons Congress, Port Elizabeth. Numanoglu, A., Millar, A.J., Andronikou, S. & Rode, H. 2000. Paediatric vascular injuries. Paper presented at Millipaed Conference, Sun City. Numanoglu, A., Millar, A.J., Andronikou, S. & Rode, H. 2000. Paediatric vascular injuries. Paper presented at Association of Surgeons Conference, Port Elizabeth. Seggie, R. 2000. Radiographic appearances of the respiratory system. Paper presented at Workshop of Pattern Recognition of the Chest, Groote Schuur Hospital. Seggie, R. 2000. Radiographic appearances of the heart. Paper presented at Workshop of Pattern Recognition of the Chest, Groote Schuur Hospital. Struwe, F.G., Davies, J.Q., Andronikou, S., Fieggen, A.G. & Kaschula, R.O.C. 2000. Clinico- pathological findings in three cases of hemimegalencephaly. Paper presented at Institute of Child Health and University of Cape Town Research Day 2000, Institute for Child Health, Cape Town.
190
UNIVERSITY PUBLICATIONS AND PUBLICATIONS OF A POPULAR NATURE
Andronikou, S., Welman, C.J. & Kader, E. 2000. Periosteal reactions in African children. South African Journal of Radiology 4(2): 4-10. Andronikou, S., Welman, C.J. & Kader, E. 2000. A trio of multiple Wilms’ tumours [case report]. South African Journal of Radiology 4(3): 4-8. Andronikou, S., Welman, C.J. & Kader, E. 2000. Barium peritonitis with barium entering the lymphatic system [case report]. South African Journal of Radiology 4(3): 14-16. Andronikou, S., Welman, C.J. & Kader, E. 2000. Paediatric calvarial tuberculosis [case report]. South African Journal of Radiology 4(3): 20-22. Andronikou, S., Dix-Peek, S. & Meerkotter, D. 2000. Five cases of paediatric cervical spine distraction injury. South African Journal of Radiology 4(4): 8-12. Andronikou, S., Welman, C., Kader, E. & Joubert, R. 2000. Clinical images: Computed tomography features of venous sinus thrombosis and venous infarction in children. South African Journal of Radiology 4(4): 14-15. Beningfield, S.J. 2000. Web-based radiology practice. South African Journal of Radiology 4(4): 18- 24.
191
DEPARTMENT OF SURGERY
HEAD OF DEPARTMENT - Professor John Terblanche
DEPARTMENTAL CONTACT DETAILS
Postal address: Department of Surgery Health Sciences Faculty Anzio Road Observatory 7925 South Africa Telephone: SA (21) 406-6229 Fax: SA (21) 448-6461 e-mail: [email protected] web-page: http://www.uct.ac.za/depts/chm/surgery.htm
DEPARTMENTAL PROFILE
The Department of Surgrey comprises of four General Surgical Firms specializing in hepato-biliary- pancreatic surgery, surgical oncology and endocrine surgery, vascular surgery and colorectal surgery, as well as the Trauma Unit, the Intensive Care Unit and Transplant Unit. Despite the heavy clinical load, research in the various disciplines remains a high priority. The high research output in the form of publication of chapters in books and articles in peer reviewed journals have been remarkable despite cutbacks in financial support. There have also been significant contributions at major International and National conferences. Surgical Research in the J S Marais Surgical Laboratory and the Microsurgery Laboratory continues to expand, with increasing collaboration with other Departments in the Faculty and research institutes elsewhere in the world. The Department is part of the MRC/UCT Liver Research Centre, and has made significant contributions in the understanding and treatment of liver disease.
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG TERM CONTRACT STAFF
UNIVERSITY STAFF PAWC STAFF Full professors 1 Senior Specialist / Associat 3 Chief Research officers 2 eProfessor Technical Support Staff 1 Senior Specialists / Senior 2 Admin & Clerical Staff 4 Lecturers Departmental 6 Specialist Scientists 1 Assistants Admin & Clerical Staff 1 TOTAL 14 Research Officers 3 Lecturers 7 Senior Lecturers (part-time) 21 JMS STAFF SUBTOTAL 38 Professors 3 SUBTOTAL 3
TOTAL: 55
HONORARY STAFF Honorary lecturers 4 TOTAL 4 192
RESEARCH FIELDS
PERMANENT STAFF
Professor J Terblanche Head of Department & Division, Department of Surgery. Co-Director: Liver Research Centre; Portal hypertension; injection sclerotherapy; liver tumours; liver resection; bile duct disease Professor D M Dent Head: Oncology / Endocrine Unit; Breast cancer; gastric cancer; endocrine neoplasm Professor E J Immelman Head: Vascular Unit (For 1999); Venous thrombosis; thrombolysis in acute arterial occlusion; pulse generated run-off; arterial trauma; diabetic foot Professor PC Bornman Head of Surgical Gastroenterology; Acute and chronic pancreatitis; pancreatic carcinoma; choledocholithiasis; ERCP; portal hypertension; laparoscopic surgery Assoc. Professor JEJ Krige Surgical Gastronenterology; Portal hypertension; injection sclerotherapy; liver resection; liver tumours; hydatid disease; liver trauma Assoc. Professor D Kahn Head: Organ transplantation and Surgical Research Laboratories; Liver regeneration; transplantation; xenotransplantation Assoc. Professor PA Goldberg Head of Colorectal Unit; Colorectal cancer; inflammatory bowel disease; colonic motility; sphincter saving surgery; constipation; HNPCC Dr MV Madden Colorectal Unit; HNPCC (Hereditary non-polypoidal colon cancer) Dr A Nicol Head of Trauma Unit Dr W L Michell Head: Surgical Intensive Care Unit; Sepsis; nutrition; scoring systems Dr A B van As Trauma Unit; Reperfusion injury in transplantation Dr A Mall Surgical Laboratories; Gastric Mucin Mr GHC Engelbrecht Microsurgery Laboratory; Microsurgery
DISTINGUISHED VISITORS
Professor R W Strong (Visiting Professor) Hepato-biliary surgery J H Louw (Visiting Professor) Hepato-biliary surgery Professor Lewis Spitz (Penman Visiting Professor) Paediatric Surgery Penman Visiting Professor Paediatric Surgery
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Bornman, P.C. & Terblanche, J. 1999. Hepatopancreatico-biliary Unit, Groote Schuur Hospital and University of Cape Town, South Africa. HPB Clinic around the World. Hepatobiliary International 1999 HPB 4: 187-189. Botha, J.F., Krige, J.E.J. & Bornman, P.C. 2000. Current perspectives in the endoscopic management of non-variceal upper gastrointestinal bleeding. Digestive Endoscopy 12: 3-7. Botha, J.F., Spearman, C.W., Millar, A.J.W., Michell, L., Gordon, P., Lopez, T., Butt, A., Thomas, J., McCulloch, M., James, M., Kirsch, R.E., Terblanche, J. & Kahn, D. 2000. Ten years of liver transplantation at Groote Schuur Hospital. South African Medical Journal 90(9): 880. Botha, J.F., Tandon, V., Linley, W., Mall, A., Davsion, D., McKenzie, I., Kahn, D. & Sandrin, M. 2000. Prolonged survival of baboon renal allografts using idarubicin conjugated anti-CD4 monoclonal antibodies. Transplantation International 13 (Suppl 1): S480-S481. 193
Goldberg, P.A., Grobbelaar, J.J., Madden, M.V., Kotze, M.J., Marx, M.P., Harocopos, C. & de Jong, G. 2000. Inherited Colon Cancers. South African Journal of Medicine 90: 703-704. Kaye, P., Radebold, K. & Dent, D.M. 2000. Expression of p53 and p21waf1/cip1 in gastric carcinoma: lack of inter-relationship, or correlation with prognosis. European Journal of Surgical Oncology 26: 39-43. Krige, J.E.J., Bornman, P.C., Goldberg, P.A. & Terblanche, J. 2000. Variceal Rebleeding and Recurrence after endoscopic injection sclerotherapy: A Prospective Evaluation in 204 patients. Archives of Surgery 135: 1315-1322. Letier, M.H., Krige, J.E.J., Lemmer, E.R. & Terblanche, J. 2000. Injection sclerotherapy for variceal bleeding in patients with irresectable hepatocellular carcinoma. Hepato-Gastroenterology 47: 1672-1676. Mall, A.S., Lotz, Z., Tyler, M., McLeod, H., Hickman, R., Dent, D.M. & Kahn, D. 2000. Increased fragmentation of MUC5AC mucin in gastric juice of patients with ulceration and carcinoma. South African Journal of Science 96 (1): 39-43. Marr, J.D.F., Krige, J.E.J. & Terblanche, J. 2000. Analysis of 153 gunshot wounds of the liver. British Journal of Surgery 87: 1030-1034. Pontin, A.R., Pascoe, M.D., Botha, J.F., Tandon, V. & Kahn, D. 2000. Does rural follow-up of renal allografts give impaired graft survival. Transplant International 13: S92-S94 Ramesar, R.S., Madden, M.V., Martin, R., Goldberg, P.A. & Westbrook, C. 2000. Hereditary nonpolyposis colorectal cancer (HNPCC) due to mutation in the hMLHi gene: evolution of management. South African Journal of Medicine 2000; 90: 709-714. Shapiro, S., Rosenberg, L., Hoffman, M., Truter, H., Cooper, D., Rao, S., Dent, D.M., Gudgeon, A., van Zyl, J., Katzenellenbogen, J. & Bailie, R. 2000. Risk of breast cancer in relation to the use of injectable contraceptives and combined estrogen / progesterone contraceptives. American Journal of Epidemology 151: 396-403.
CHAPTERS IN BOOKS
Krige, J.E.J. & Bornman, P.C. 2000. Infections in hepatic biliary and pancreatic surgery. In Blumgart, L.H. & Fong, Y. (eds) Surgery of the Liver and Biliary Tract. Third Edition 1: 151-166. London, Edinburgh, New York, Philadelphia: WB Saunders Co. Krige, J.E.J. & Terblanche, J. 2000. Endoscopic therapy in the management of esophageal varices: Injection sclerotherapy and variceal ligation. In Blumgart, L.H. & Fong, Y. (eds) Surgery of the Liver and Biliary Tract. Third Edition 2: 1885-1906. London, Edinburgh, New York, Philadelphia: WB Saunders Co.
CONFERENCE ABSTRACTS
Anderson, F. & Nicol, A. 2000. Laparoscopic evaluation of tangential GSW’s of abdomen. Surgical Research Society Meeting, Cape Town. De Minck, J., Antonissen, Nicol, A. 2000. Occupational exposure to HIV. Surgical Research Society Meeting, Cape Town. Douie, W.J.P., Bornman, P.C., van Wyk, M., Kidd, M., Johnson, C.D. & Fitzsimmons, D. 2000. Which factors influence quality of life (QoL) in patients with chronic pancreatitis after surgery for intractable pain? Association of Surgeons of South Africa 22nd Biennial Congress Feather Market Center, Port Elizabeth. South African Journal of Surgery 38: 23. Douie, W.J.P., Bornman, P.C., van Wyk, M., Kidd, M., Krige, J.E.J., Beckingham, I. & Terblanche, J. 2000. Is surgery a viable therapeutic option in the management of pain in chronic pancreatitis. Association of Surgeons of South Africa 22nd Biennial Congress Feather Market Center, Port Elizabeth, South African Journal of Surgery Suppl. 38: 18. Exadactylos, Bautz, P.C. & Nicol, A. 2000. Front room thoracotomies. European Association for Trauma and Emergency Surgery. Goddard, E.A., Spearman, C.W.N., McCulloch, M.I., Millar, A.J.W. & Kahn, D. 2000. Cytomegalovirus (CMV) infection in paediatric liver transplant recipients in a developing country. Paediatric Transplantation 4 (2): 48. Hameed, M.F., Krige, J.E.J. & Nicol, A. 2000. Local complications after surgery for penetrating pancreatic injuries. Surgical Research Society Meeting, Cape Town. Hameed, M.F., Krige, J.E.J. & Nicol, A. 2000. Morbidity of pancreatic resections for trauma. Association of Surgeons of South Africa 22nd Biennial Congress Feather Market Center, Port Elizabeth.
194
Hameed, M.F., Krige, J.E.J. & Nicol, A. 2000. What is the morbidity of pancreatic resections for trauma? Association of Surgeons of South Africa 22nd Biennial Congress Feather Market Center, Port Elizabeth. South African Journal of Surgery Suppl 38:15. Kowalczyk, J., Theunissen, D. & Immelman, E.J. 2000. Implications of fiscal and staff cuts on tertiary vascular services in the Western Cape. VASSA Conference, Port Elizabeth. South African Journal of Surgery 38: 68. Krige, J.E.J., Beningfield, S.J., Bornman, P.C. & Terblanche, J. 2000. Subparietal hepaticojejunal access loop for intrahepatic stones. 4th World Congress, Brisbane Australia. Hepatobilary International 2: 118. Krige, J.E.J., Beningfield, S.J., Bornman, P.C. & Terblanche, J. 2000. Percutaneous selective hepatic artery embolization is the treatment of choice for hepatic haemobilia. 4th World Congress, Brisbane Australia. Hepatobiliary International 2: 245. Krige, J.E.J., Bornman, P.C. & Terblanche, J. 2000. Pancreatoduodenectomy for complex pancreatic trauma. 4th World Congress, Brisbane Australia. Hepatobiliary International 2: 214. Krige, J.E.J., Bornman, P.C. & Terblanche, J. 2000. Sclerotherapy versus surgery for longterm management of bleeding esophageal varices: Analysis of a prospective randomized controlled trial. 4th World Congress, Brisbane Australia. Hepatobiliary International 2: 274. Krige, J.E.J., Bornman, P.C. & Terblanche, J. 2000. Variceal rebleeding and recurrence after injection sclerotherapy: a prospective evaluation in 204 patients. 4th World Congress, Brisbane Australia. Hepatobiliary International 2: 274. Krige, J.E.J., Douie, W.J.P., Bornman, P.C. & Terblanche, J. 2000. Variceal re-bleeding and recurrence after injection sclerotherapy: a prospective evaluation in 204 patients. South African Journal of Surgery Suppl. 38: 17. Krige, J.E.J., Marr, J.D.F., Bornman, P.C. & Terblanche, J. 2000. Gunshot wounds of the liver. An analysis of 153 cases. 4th World Congress, Brisbane, Australia. Hepatobiliary International 2: 245. Krige, J.E.J., Swart, N., Bornman, P.C. & Terblanche, J. 2000. Liver resection for colorectal metastases. Association of Surgeons of South Africa 22nd Biennial Congress Feather Market Center, Port Elizabeth. South African Journal of Surgery Suppl 38:11. Mall, A., Blows, D., Taylor, K., Tyler, M., Lotz, Z. & Kahn, D. 2000. Is there an association between H heilmannii infection, mucus degradation and ulceration of the pars oesophagea in the bile duct ligated pig? A Pilot Study. Surgical Research Society Meeting, Cape Town. Mall, A., Hall, P., Barnard, R., Ho, S.B., van Rensburg, M. & Kahn, D. 2000. The expression of Mucin in Cholangiocarcinoma. An Immunohistochemical Study. Surgical Research Society Meeting, Cape Town. Mall, A., Suleman, N., Taylor, K., Tyler, M., Lotz, Z., Kidd, M. & Kahn, D. 2000. The incidence of Helicobacter heilmannii in the normal pig stomach. Surgical Research Society Meeting, Cape Town, July. Mall, A., Suleman, N., Taylor, K., Tyler, M., Lotz, Z., Kidd, M. & Kahn, D. 2000. Is there an association between H heilmannii infection, mucus degradation and ulceration of the pars oesophagea of the abattoir pig stomach. Surgical Research Society Meeting, Cape Town. McCulloch, M., Andronikou, S., Hoffman, E.B., Goddard, E. & Kahn, D. 2000. Avascular necrosis of the hip in paediatric renal transplant recipients. Paediatric Transplantation 4 (2): 122. McCulloch, M., Gilbert, R., Eley, B., Zuhlke, L., McCurdie, F., Pascoe, M., Pontin, A., Millar, A.J.W. & Kahn, D. 2000. Overview of paediatric renal transplant programme in a developing country. Paediatric Transplantation 4 (2): 103. Millar, A.J.W., Spearman, C.W.N., McCulloch, M., Goddard, L., Rode, H. & Kahn, D. 2000. Paediatric liver transplantation in a developing country – taking stock. Paediatric Transplantation 4 (2): 129. Mirza, K.M., Krige, J.E.J., Beningfield, S., Cullis, P.C. & Terblanche, J. 2000. Longterm management of intrahepatic stones. Association of Surgeons of South Africa 22nd Biennial Congress Feather Market Center, Port Elizabeth. South African Journal of Surgery Suppl. 38:17. Motale, P., Mall, A., Lotz, A., Tyler, M., Sheperd, E., Hall, P., Hickman, R. & Kahn, D. 2000. The effect of mycophenolate mofetil on liver regeneration. Surgical Research Society Meeting, Cape Town. Navsaria, P. & Nicol, A. 2000. Extraperitoneal rectal injuries. Association of Surgeons of South Africa 22nd Biennial Congress Feather Market Center, Port Elizabeth. Navsaria, P. & Nicol, A. 2000. Extraperitoneal rectal injuries. Surgical Research Society Meeting, Cape Town. Nicol, A. 2000. The management of penetrating thoracic trauma at Groote Schuur Hospital. Thuringen Vascular Society of Germany.
195
Omotoso, B., Immelman, E.J., Oliver, S. & Roditi, D. 2000. Antibiotic prophylaxis in vascular surgery: Literature guidance. VASSA Conference, Port Elizabeth. South African Journal of Surgery 38: 67. Rowe, P., Bautz, P.C., Nicol, A. & Kahn, D. 2000. Accuracy of diagnostic tests for haemopericardium. Surgical Research Society Meeting, Cape Town. Spearman, C.W.N., McCulloch, M., Goddard, E., Millar, A.J.W., Hartley, P. & Kahn, D. 2000. Post- transplant lymphoproliferative disease (PLTD) in paediatric liver transplant recipients in a developing country. Paediatric Transplantation 4 (2): 53. Swart, N., Douie, W.J.P., Krige, J.E.J. & Bornman, P.C. 2000. Is the training of surgical registrars adequate? Association of Surgeons of South Africa 22nd Biennial Congress Feather Market Center, Port Elizabeth. South African Journal of Surgery Suppl 38: 13. Swart, N., Stevens, Nicol, A. 2000. Morbidity and management of stomas in trauma. Surgical Research Society Meeting, Cape Town. Van As, A.B., Omoshoro-Jones, O., van Deurzen, D., Bautz, P.C. & Immelman, E.J. 2000. Selective conservative management for gunshot wounds to the neck: An audit of 118 patients. VASSA Conference, Port Elizabeth. South African Journal of Surgery 38: 73 Van Rensburg, M., Krige, J.E.J., Beckingham, I., Bornman, P.C. & Terblanche, J. 2000. Traumatic biliary fistula after liver injury. Association of Surgeons of South Africa 22nd Biennial Congress Feather Market Center, Port Elizabeth. South African Journal of Surgery Suppl 38: 16.
INVITATIONS TO PARTICIPATE IN JOURNAL DEBATE; PEER EXCHANGE AND INSIGHTS IN MEDICINE
Behrns, K.E., Bornman, P.C., Bradley, E.L., Foxx-Oernestein, A.E., Heider, T.R. & Theodre, N.P. 2000. Acute Pancreatitis and Pseudocyst Controversies in Management. Medical Crossfire General Surgery Ed. May 1: 18-31. Krige, J.E.J., Bornman, P.C. & Terblanche, J. 1999. Complications of Sclerotherapy. In Sivak, M.V. (ed.) Gastroenterology Endoscopy, 2nd Edition: CD Rom Chapter. Philadelphia: WB Saunders Co.
THESIS AND DISSERTATIONS PASSED FOR HIGHER DEGREES
Van As, A.B. 2000. Improvement of liver transplantation by reducing preservation-reperfusion injury. Ph.D. thesis, University of Cape Town.
196
DEPARTMENT OF UROLOGY
HEAD OF DEPARTMENT – Professor J H Naudé
DEPARTMENTAL CONTACT DETAILS
Postal Address: Department of Urology UCT Medical School Area E26 New Groote Schuur Hospital Observatory 7925 Telephone: SA (21) 406-6529 Fax: SA (21) 406-6122 e-mail: [email protected]
DEPARTMENTAL PROFILE
The department renders a urological service in four hospitals. In addition to our regular registrars we are training one supernumerary registrar from the SADF.
The department is involved in ongoing collaborative work with renal transplantation, gynaecology in the management of female incontinence and with oncology. Work is done in the field of reconstructive urological surgery. Clinics for the management of erectile dysfunction and metabolic investigation of nephrolithiasis are providing research material. Collaborative research is done with centres in the UK, Scandinavia and the USA on aspects of reconstructive urological surgery.
DEPARTMENTAL STATISTICS
STUDENTS PERMANENT AND LONG TERM
CONTRACT STAFF Associate Professor (HOD) 1 Masters 6 th th Senior Lecturers 3 Undergraduate (4 & 5 year) 340 Administrative 1 TOTAL 346 Sessional Senior Lecturers 6 TOTAL 11
RESEARCH FIELDS
PERMANENT STAFF
Associate Professor J H Naudé Head of Department; Reconstructive urological surgery; urethral stricture disease; ureteric strictures; minimally invasive surgery Dr A R Pontin Senior Lecturer; Urological oncology; female incontinence; renal infection in diabetics Dr R D Barnes Senior Lecturer; Urological oncology; metabolic aspects of renal calculus disease Dr L Jee Senior Lecturer (part-time); Paediatric urology
197
RESEARCH OUTPUTS
CONFERENCE ABSTRACTS
Barnes, R.D. 2000. Staghorn calculi in Cape Town. The Royal Society of Medicine Section of Urology and the University of Cape town, Department of Urology – Joint Winter Meeting, Cape Town. Bhorat, A. & Dhiman, P. 2000. The effect of anastomotic urethroplasty upon erection of the glans penis. 98th Annual Meeting of the American Urological Association, New York Section. Bhorat, A. 2000. An absorbable stent in the treatment of urethral strictures. The Royal Society of Medicine Section of Urology and the University of Cape town, Department of Urology – Joint Winter Meeting, Cape Town. Botha, W. 2000. Patching tuberculous ureteric strictures. The Royal Society of Medicine Section of Urology and the University of Cape town, Department of Urology – Joint Winter Meeting, Cape Town. Botha, W. & Naudé, J.H. 2000. Penetrating injuries of the ureter: The Cape Town Experience. 98th Annual Meeting of the American Urological Association, New York Section. Botha, W. 2000. Penetrating injuries of the ureter: The Cape Town experience. The XXIII Biennial Congress of the Urological Association of South Africa. Le Roux, P. 2000. Endoscopic tissue graft urethroplasty. The Royal Society of Medicine Section of Urology and the University of Cape town, Department of Urology – Joint Winter Meeting, Cape Town. Le Roux, P.J. & Naudé, J.H. 2000. Endoscopic tissue graft urethroplasty. 98th Annual Meeting of the American Urological Association, New York Section. MacGillivray, D. 2000. The G U tuberculosis of yesteryear today. The price of manhood. The Royal Society of Medicine Section of Urology and the University of Cape town, Department of Urology – Joint Winter Meeting, Cape Town. Naudé, J.H. Make love not war! A new vacuum erection device. 98th Annual Meeting of the American Urological Association, New York Section. Naudé, J.H. 2000. Magistral Lecture. The European Association of Urology Congress 2000, Cape Town. Naudé, J.H. 2000. An African Urological Safari. A personal experience of urological conditions occurring with increased frequency in South Africa. 98th Annual Meeting of the American Urological Association, New York Section. Naudé, J.H. 2000. Magistral Lecture. The Royal Society of Medicine Section of Urology and the University of Cape Town, Department of Urology – Joint Winter Meeting, Cape Town. Naudé, J.H. 2000. Patch Ureteroplasty. 98th Annual Meeting of the American Urological Association, New York Section. Naudé, J.H. 2000. The treatment of urethral strictures with an absorbable spiral stent: 4 year follow up. The XXIII Biennial Congress of the Urological Association of South Africa. Naudé, J.H. 2000. Treatment of urethral strictures: from ancient Egypt to space age and back again. The Royal Society of Medicine Section of Urology and the University of Cape town, Department of Urology – Joint Winter Meeting, Cape Town. Pontin, A.R. & Barnes, R.D. 2000. Spectrum of renal abscesses. 98th Annual Meeting of the American Urological Association, New York Section. Pontin, A.R. 2000. Emphysematous pyelonephritis. Spare the knife and loose the patient? The Royal Society of Medicine Section of Urology and the University of Cape town, Department of Urology – Joint Winter Meeting, Cape Town. Pontin, A.R. 2000. Evidence favouring nephrectomy in diabetic patients with Emphysematous Pyelonephristis. American Urological Association, Atlanta. Pontin, A.R. 2000. Spectrum of Renal Abscess’s. Millennium International Urology Congress, Delhi. Sekhu, N. & MacGillivray, D. 2000. Complications of tribal circumcision. 98th Annual Meeting of the American Urological Association, New York Section. Tyler, F. 2000. Urethral self-dilatation made more effective. 98th Annual Meeting of the American Urological Association, New York Section.
198
HSRC/UCT CENTRE FOR GERONTOLOGY
HEAD OF DEPARTMENT – Dr Monica Ferreira
DEPARTMENTAL CONTACT DETAILS
Postal address: HSRC/UCT Centre for Gerontology Faculty of Health Sciences University of Cape Town Observatory 7925 South Africa Telephone: SA (21) 448-4840/1/2 Fax: SA (21) 447-8714 e-mail: [email protected]
DEPARTMENTAL PROFILE
The Centre for Gerontology was established in 1991 as a joint venture of the Human Sciences Research Council and the University. The inter-disciplinary Centre aims to enhance the quality of life and well- being of older South Africans by (1) identifying and conducting relevant research on problems and needs, (2) providing a meeting ground for researchers, policy makers, field professionals and other public officials and citizens to link research findings with policy and practice, (3) promoting research capacity building and gerontological education and training, and (4) disseminating knowledge and information on ageing. Current research areas are economics of ageing, social and community care, impact of HIV/AIDS on older persons, elder abuse, age-related cognitive impairment and health development. The Centre has published the Southern African Journal of Gerontology bi-annually.
DEPARTMENTAL STATISTICS 2000
PERMANENT AND LONG TERM
CONTRACT STAFF
Director 1
Research Staff 2
Administrative and Clerical Staff 1
TOTAL 4
RESEARCH FIELDS
PERMANENT STAFF
Dr Monica Ferreira Director, Centre for Gerontology; social gerontology; population ageing; medical sociology; ageing in Africa Mrs Johannah Keikelame Senior Scientific Officer; social, health and community care and development; empowerment Ms Yoemna Mosaval Research Assistant Mrs Alayne Opperman Administrative Assistant
199
DISTINGUISHED VISITORS
Professor Nana Apt Director, Centre for Social Policy Studies, Ghana; ageing in Africa Professor John Copeland Director, Institute of Human Ageing, Liverpool, UK; dementia research Dr Martin Prince London School of Tropical Hygiene and Medicine, UK; dementia research in developing countries Dr Andreas Sagner Institute of Ethnology and African Studies, Munich, Germany; old age anthropology Dr Els van Dongen Medical Anthropology Unit, University of Amsterdam, the Netherlands; remembrance, mental health in old age Ms Rosemary Williams Medical Social Worker, Ottawa General Hospital, Canada; elder abuse, palliative care
RESEARCH OUTPUTS
RESEARCH PAPERS AND REFEREED ARTICLES
Ferreira, M. 2000. Growing old in the new South Africa. Ageing International 25(4): 32-46. Ferreira, M. 2000. AIDS – the mad-dog curse of Africa. Editorial. Southern African Journal of Gerontology 9(1): 1-3. Sagner, A. 2000. Ageing and social policy in South Africa: historical perspectives with particular reference to the Eastern Cape. Journal of Southern African Studies 26(2): 523-553.
PUBLISHED CONFERENCE PROCEEDINGS
Ferreira, M. 2000. Cape Town, South Africa. In Living conditions of low-income older persons in human settlements. A global survey in connection with the International Year of Older Persons 1999. Proceedings of a Workshop on Living Conditions of Older People in Human Settlements, Amersfoort, The Netherlands. New York: United Nations Centre for Human Settlements (HABITAT) 39-44. (http://www.theipa.org/publication/op2new.pdf)
UNIVERSITY PUBLICATIONS AND WORKS OF A POPULAR NATURE
Ferreira, M. & Makoni, S.B. 2000. Does Alzheimer’s disease occur in Africans? ARDA (Newsletter of the Alzheimer’s and Related Dementias Association) December: 1-3. Keikelame, M.J. 2000. Abigail Women’s Movement. A community-based support system for older persons in Site B, Khayelitsha – an evaluation. Cape Town: HSRC/UCT Centre for Gerontology. Keikelame, M.J. & Ferreira, M. 2000. Mpathekombi, ya bantu abadala: elder abuse in black townships on the Cape Flats. Cape Town: HSRC/UCT Centre for Gerontology. (In partnership with Ikamva Labantu Project.) Mosaval, Y. & Ferreira, M. 2000. Bejaarde ouers het las geword: disrespect and elder abuse in the Muslim community of the Cape Peninsula. Cape Town: HSRC/UCT Centre for Gerontology.
CONSULTANCY AND OTHER ACTIVITY BASED ON EXPERTISE DEVELOPED IN RESEARCH
Dr Monica Ferreira is an executive board member of the African Gerontological Society (Ages International); an advisory board member of the African Foundation for Research and Interdisciplinary Training in Ageing (AFRITA); and a board member of the Abbeyfield Society of South Africa. She serves in several United Nations Program on Aging expert groups; on the UN Technical Committee to review the International Plan of Action on Ageing; and in an Organisation of African Unity (OAU)/HelpAge International (HAI) expert group. She is the founding editor of the Southern African Journal of Gerontology. Mrs Mpoe Johannah Keikelame is a national executive committee member of the South African Gerontological Association (SAGA) and an affiliate of the Buzani Kubawo Inyangas’ Association.
200