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VIEWS & REVIEWS Arterial ischemic stroke in HIV Defining and classifying etiology for research studies Laura A. Benjamin, ABSTRACT MRCP, PhD HIV infection, and potentially its treatment, increases the risk of an arterial ischemic stroke. Mul- Alan Bryer, FCN (SA), tiple etiologies and lack of clear case definitions inhibit progress in this field. Several etiologies, PhD many treatable, are relevant to HIV-related stroke. To fully understand the mechanisms and the Sebastian Lucas, FRCP, terminology used, a robust classification algorithm to help ascribe the various etiologies is FRCPath needed. This consensus paper considers the strengths and limitations of current case definitions Alan Stanley, FCN (SA) in the context of HIV infection. The case definitions for the major etiologies in HIV-related strokes Theresa J. Allain, FRCP, were refined (e.g., varicella zoster vasculopathy and antiphospholipid syndrome) and in some in- PhD stances new case definitions were described (e.g., HIV-associated vasculopathy). These case def- Elizabeth Joekes, FRCR initions provided a framework for an algorithm to help assign a final diagnosis, and help classify Hedley Emsley, FRCP, the subtypes of HIV etiology in ischemic stroke. Neurol Neuroimmunol Neuroinflamm 2016;3:e254; PhD doi: 10.1212/NXI.0000000000000254 Ian Turnbull, FRCR Colin Downey, MIBMS GLOSSARY Cheng-Hock Toh, FRCP, ACL 5 anticardiolipin antibodies; anti-b2GP1 5 anti–b2-glycoprotein I; APS 5 antiphospholipid syndrome; HSV 5 herpes PhD simplex virus; IgG 5 immunoglobulin G; LA 5 lupus anticoagulant; RPR 5 rapid plasma reagin; SVD 5 small vessel disease; 5 5 5 Kevin Brown, FRCPath, TB tuberculosis; TOAST Trial of Org 10172 in Acute Stroke Treatment; TTP thrombotic thrombocytopenic purpura; VDRL 5 Venereal Disease Research Laboratory; VZV 5 varicella zoster virus. -
Drug Mechanisms
REVIEW OF OPTOMETRY EARN 2 CE CREDITS: Don’t Be Stumped by These Lumps and Bumps, Page 70 ■ VOL. 154 NO. 4 April 15, 2017 www.reviewofoptometry.com TH ■ 10 ANNUAL APRIL 15, 2017 PHARMACEUTICALS REPORT ■ ANNUAL PHARMACEUTICALS REPORT An Insider’s View of DRUG MECHANISMS ■ CE: DIFFERENTIAL DIAGNOSIS OF EYELID LESIONS CE: DIFFERENTIAL DIAGNOSIS OF EYELID LESIONS You can choose agents with greater precision—and evaluate their performance better—when you know what makes them tick. • How Antibiotics Work—and Why They Sometimes Don’t, Page 30 • Glaucoma Therapy: Finding the Right Combination, Page 46 • Anti-inflammatories: Sort Out Your Many Steroids and NSAIDs, Page 40 • Dry Eye: Master the Science Beneath the Surface, Page 56 • Resist the Itch: Managing Allergic Conjunctivitis, Page 64 001_ro0417_fc.indd 1 4/4/17 2:21 PM . rs ke ee S t S up r po fo rtiv Com e. Nature Lovers. Because I know their eyes are prone to discomfort, I prescribe the 1-DAY ACUVUE® MOIST Family. § 88% of all BLINK STABILIZED® Design contact lenses were fi tted in the fi rst attempt, and 99.5% within 2 trial fittings. ** Based on in vitro data. Clinical studies have not been done directly linking differences in lysozyme profi le with specifi c clinical benefi ts. * UV-blocking percentages are based on an average across the wavelength spectrum. † Helps protect against transmission of harmful UV radiation to the cornea and into the eye. ‡ WARNING: UV-absorbing contact lenses are NOT substitutes for protective UV-absorbing eyewear such as UV-absorbing goggles or sunglasses because they do not completely cover the eye and surrounding area. -
Herpesviruses
J Clin Pathol: first published as 10.1136/jcp.32.9.859 on 1 September 1979. Downloaded from Journal of Clinical Pathology, 1979, 32, 859-881 Herpesviruses MORAG C. TIMBURY' AND ELIZABETH EDMOND2 From the 'Department of Bacteriology, Royal Infirmary, Glasgow and the 2Regional Virus Laboratory, City Hospital, Greenbank Drive, Edinburgh, UK Herpesviruses are ubiquitous in both human and tion (Plummer et al., 1970) or microneutralisation animal populations (Plummer, 1967). The four tests (Pauls and Dowdle, 1967) are often used for human herpesviruses are herpes simplex (HSV), this, but differentiating the two types of virus today varicella-zoster (VZ), cytomegalovirus (CMV), and can probably be done more easily by biochemical Epstein-Barr (EBV) viruses, and all exhibit the prop- methods. Thus the DNA of the viruses can be dis- erty, rare among human pathogenic viruses, of tinguished by restriction enzyme analysis (Skare et remaining latent within the body after primary infec- al., 1975). Similarly, many of the virus polypeptides tion. Latent virus persists for many years-probably produced in infected cells by the two types of virus throughout life-and in some patients reactivates to can be distinguished by polyacrylamide gel electro- cause secondary or recurrent infections. Human phoresis (Courtney and Powell, 1975). herpesviruses can almost be regarded as part of the commensal flora, and certainly HSV is present in LABORATORY DIAGNOSIS the saliva of healthy people from time to time HSV-1 infections are most rapidly diagnosed by (Douglas and Couch, 1970). The viruses exhibit a isolation of the virus in cell cultures such as BHK21 remarkably successful parasitism since the upset to or RK1 3 cells (Grist et al., 1979). -
The Ophthalmology Examinations Review
The Ophthalm logy Examinations Review Second EditionSecond Edition 7719tp.indd 1 1/4/11 8:13 PM FA B1037 The Ophthalmology Examinations Review This page intentionally left blank BB1037_FM.indd1037_FM.indd vvii 112/24/20102/24/2010 22:31:16:31:16 PPMM The Ophthalm logy Examinations Review Second Edition Tien Yin WONG National University of Singapore, Singapore & University of Melbourne, Australia With Contributions From Chelvin SNG National University Health System, Singapore Laurence LIM Singapore National Eye Centre, Singapore World Scientific NEW JERSEY • LONDON • SINGAPORE • BEIJING • SHANGHAI • HONG KONG • TAIPEI • CHENNAI 7719tp.indd 2 1/4/11 8:13 PM Published by World Scientific Publishing Co. Pte. Ltd. 5 Toh Tuck Link, Singapore 596224 USA office: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601 UK office: 57 Shelton Street, Covent Garden, London WC2H 9HE Library of Congress Cataloging-in-Publication Data Wong, Tien Yin. The ophthalmology examinations review / Tien Yin Wong ; with contributions from Chelvin Sng, Laurence Lim. -- 2nd ed. p. ; cm. Includes index. ISBN-13: 978-981-4304-40-5 (hardcover : alk. paper) ISBN-10: 981-4304-40-9 (hardcover : alk. paper) ISBN-13: 978-981-4304-41-2 (pbk. : alk. paper) ISBN-10: 981-4304-41-7 (pbk. : alk. paper) 1. Ophthalmology--Outlines, syllabi, etc. 2. Ophthalmology--Examinations, questions, etc. I. Sng, Chelvin. II. Lim, Laurence. III. Title. [DNLM: 1. Eye Diseases--Examination Questions. 2. Ophthalmologic Surgical Procedures--Examination Questions. WW 18.2] RE50.W66 2011 617.7--dc22 2010054298 British Library Cataloguing-in-Publication Data A catalogue record for this book is available from the British Library. -
Communicable Disease Toolkit Liberia
WHO/CDS/2004.24 COMMUNICABLE DISEASE TOOLKIT LIBERIA 1. COMMUNICABLE DISEASE PROFILE World Health Organization 2004 Communicable Disease Working Group on Emergencies, WHO/HQ The WHO Regional Office for Africa (AFRO) WHO Office, Liberia © World Health Organization 2004 All rights reserved. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. The World Health Organization does not warrant that the information contained in this publication is complete and correct and shall not be liable for any damages incurred as a result of its use. Further information is available at: CDS Information Resource Centre, World Health Organization, 1211 Geneva 27, Switzerland; fax: (+41) 22 791 4285, e-mail: [email protected] Communicable Disease Toolkit for LIBERIA 2004: Communicable Disease Profile. ACKNOWLEDGMENTS Edited by Dr Michelle Gayer, Dr Katja Schemionek, Dr Monica Guardo, and Dr Máire Connolly of the Programme on Communicable Diseases in Complex Emergencies, WHO/CDS. This Profile is a collaboration between the Communicable Disease Working Group on Emergencies (CD-WGE) at WHO/HQ, the Division of Communicable Disease Prevention and Control (DCD) at WHO/AFRO and the Office of the WHO Representative for Liberia. -
Medical Management of Biological Casualties Handbook
USAMRIID’s MEDICAL MANAGEMENT OF BIOLOGICAL CASUALTIES HANDBOOK Sixth Edition April 2005 U.S. ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES FORT DETRICK FREDERICK, MARYLAND Emergency Response Numbers National Response Center: 1-800-424-8802 or (for chem/bio hazards & terrorist events) 1-202-267-2675 National Domestic Preparedness Office: 1-202-324-9025 (for civilian use) Domestic Preparedness Chem/Bio Helpline: 1-410-436-4484 or (Edgewood Ops Center – for military use) DSN 584-4484 USAMRIID’s Emergency Response Line: 1-888-872-7443 CDC'S Emergency Response Line: 1-770-488-7100 Handbook Download Site An Adobe Acrobat Reader (pdf file) version of this handbook can be downloaded from the internet at the following url: http://www.usamriid.army.mil USAMRIID’s MEDICAL MANAGEMENT OF BIOLOGICAL CASUALTIES HANDBOOK Sixth Edition April 2005 Lead Editor Lt Col Jon B. Woods, MC, USAF Contributing Editors CAPT Robert G. Darling, MC, USN LTC Zygmunt F. Dembek, MS, USAR Lt Col Bridget K. Carr, MSC, USAF COL Ted J. Cieslak, MC, USA LCDR James V. Lawler, MC, USN MAJ Anthony C. Littrell, MC, USA LTC Mark G. Kortepeter, MC, USA LTC Nelson W. Rebert, MS, USA LTC Scott A. Stanek, MC, USA COL James W. Martin, MC, USA Comments and suggestions are appreciated and should be addressed to: Operational Medicine Department Attn: MCMR-UIM-O U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) Fort Detrick, Maryland 21702-5011 PREFACE TO THE SIXTH EDITION The Medical Management of Biological Casualties Handbook, which has become affectionately known as the "Blue Book," has been enormously successful - far beyond our expectations. -
Formation of Hirano Bodies in Cell Culture 1941
Research Article 1939 Formation of Hirano bodies in Dictyostelium and mammalian cells induced by expression of a modified form of an actin-crosslinking protein Andrew G. Maselli, Richard Davis, Ruth Furukawa and Marcus Fechheimer* Department of Cellular Biology, University of Georgia, Athens, Georgia 30602, USA *Author for correspondence (e-mail: [email protected]) Accepted 26 February 2002 Journal of Cell Science 115, 1939-1952 (2002) © The Company of Biologists Ltd Summary We report the serendipitous development of the first pathological conditions. Furthermore, expression of the cultured cell models of Hirano bodies. Myc-epitope-tagged CT fragment in murine L cells results in F-actin forms of the 34 kDa actin bundling protein (amino acids 1- rearrangements characterized by loss of stress fibers, 295) and the CT fragment (amino acids 124-295) of the 34 accumulation of numerous punctate foci, and large kDa protein that exhibits activated actin binding and perinuclear aggregates, the Hirano bodies. Thus, failure to calcium-insensitive actin filament crosslinking activity regulate the activity and/or affinity of an actin crosslinking were expressed in Dictyostelium and mammalian cells to protein can provide a signal for formation of Hirano bodies. assess the behavior of these modified forms in vivo. More generally, formation of Hirano bodies is a cellular Dictyostelium cells expressing the CT-myc fragment: (1) response to or a consequence of aberrant function of the form ellipsoidal regions that contain ordered assemblies of actin cytoskeleton. The results reveal that formation of F-actin, CT-myc, myosin II, cofilin and α-actinin; (2) grow Hirano bodies is not necessarily related to cell death. -
Musculoskeletal Clinical Vignettes a Case Based Text
Leading the world to better health MUSCULOSKELETAL CLINICAL VIGNETTES A CASE BASED TEXT Department of Orthopaedic Surgery, RCSI Department of General Practice, RCSI Department of Rheumatology, Beaumont Hospital O’Byrne J, Downey R, Feeley R, Kelly M, Tiedt L, O’Byrne J, Murphy M, Stuart E, Kearns G. (2019) Musculoskeletal clinical vignettes: a case based text. Dublin, Ireland: RCSI. ISBN: 978-0-9926911-8-9 Image attribution: istock.com/mashuk CC Licence by NC-SA MUSCULOSKELETAL CLINICAL VIGNETTES Incorporating history, examination, investigations and management of commonly presenting musculoskeletal conditions 1131 Department of Orthopaedic Surgery, RCSI Prof. John O'Byrne Department of Orthopaedic Surgery, RCSI Dr. Richie Downey Prof. John O'Byrne Mr. Iain Feeley Dr. Richie Downey Dr. Martin Kelly Mr. Iain Feeley Dr. Lauren Tiedt Dr. Martin Kelly Department of General Practice, RCSI Dr. Lauren Tiedt Dr. Mark Murphy Department of General Practice, RCSI Dr Ellen Stuart Dr. Mark Murphy Department of Rheumatology, Beaumont Hospital Dr Ellen Stuart Dr Grainne Kearns Department of Rheumatology, Beaumont Hospital Dr Grainne Kearns 2 2 Department of Orthopaedic Surgery, RCSI Prof. John O'Byrne Department of Orthopaedic Surgery, RCSI Dr. Richie Downey TABLE OF CONTENTS Prof. John O'Byrne Mr. Iain Feeley Introduction ............................................................. 5 Dr. Richie Downey Dr. Martin Kelly General guidelines for musculoskeletal physical Mr. Iain Feeley examination of all joints .................................................. 6 Dr. Lauren Tiedt Dr. Martin Kelly Upper limb ............................................................. 10 Department of General Practice, RCSI Example of an upper limb joint examination ................. 11 Dr. Lauren Tiedt Shoulder osteoarthritis ................................................. 13 Dr. Mark Murphy Adhesive capsulitis (frozen shoulder) ............................ 16 Department of General Practice, RCSI Dr Ellen Stuart Shoulder rotator cuff pathology ................................... -
Viable Ovarian Pregnancy: Case Report
MOJ Women’s Health Case Report Open Access Viable ovarian pregnancy: case report Abstract Volume 4 Issue 1 - 2017 Ovarian pregnancy is a rare variable of ectopic pregnancy with an incidence is 1-3% 1,2 1 of all ectopic pregnancies. It still remains a diagnostic challenge. As the ovarian Ahmed Altraigey, Wael Naeem, Omar 1 2 3 pregnancy clinical presentation is similar to that of tubal one, and an accurate Khaled, Mufareh Asiri, Abdullah Asiri, ultrasound diagnosis is someway controversial, the surgical diagnosis is frequently Mohammed Hussein2 made and confirmed by histo-pathological examination. We are presenting the data of 1Department of Obstetrics and Gynecology, Benha University, two cases of viable ovarian pregnancies presented with hemodynamic instability that Egypt required immediate laparotomies. Both cases needed unilateral salpingo-oophrectomy. 2Department of Obstetrics and Gynecology, Armed Forces These clinical scenarios stresses on the necessity of starting early antenatal care and Hospitals Southern Region, Saudi Arabia having a routine transvaginal first trimester ultrasound. Also clear evidence based 3Department of Obstetrics and Gynecology, King Khalid guideline for ovarian pregnancy management should be initiated using the best University, Saudi Arabia available data on the literature. Correspondence: Ahmed Altraigey, Department of Obstetrics Keywords: ectopic pregnancy; ovarian pregnancy; laparotomy and Gynecology, King Faisal Military City, base villa 9, Khamis Mushayt, 61961, Kingdom of Saudi Arabia - 43 Benha-Zagazig Street, Mansheyet Elnoor, Benha, 13511, Arab Republic of Egypt, Egypt, Tel +966544854232, +201060885050, Email [email protected]; ahmed.abdelfattah@fmed. bu.edu.eg Received: December 18, 2016 | Published: January 03, 2017 Introduction hemoglobin (Hb) of 10.5gm/dl. -
Clinical Dermatology Notice
This page intentionally left blank Clinical Dermatology Notice Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge, changes in treatment and drug therapy are required. The editors and the publisher of this work have checked with sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication. However, in view of the possibility of human error or changes in medical sciences, neither the editors nor the publisher nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they disclaim all responsibility for any errors or omissions or for the results obtained from use of such information contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to check the product information sheet included in the package of each drug they plan to administer to be certain that the information contained in this work is accurate and that changes have not been made in the recommended dose or in the contraindications for administration. This recommendation is of particular importance in connection with new or infrequently used drugs. a LANGE medical book Clinical Dermatology Carol Soutor, MD Clinical Professor Department of Dermatology University of Minnesota Medical School Minneapolis, Minnesota Maria K. Hordinsky, MD Chair and Professor Department of Dermatology University of Minnesota Medical School Minneapolis, Minnesota New York Chicago San Francisco Lisbon London Madrid Mexico City Milan New Delhi San Juan Seoul Singapore Sydney Toronto Copyright © 2013 by McGraw-Hill Education, LLC. -
Distribution of Bronchial Gland Measurements in a Jamaican Population
Thorax: first published as 10.1136/thx.24.5.619 on 1 September 1969. Downloaded from Thorax (1969), 24, 619. Distribution of bronchial gland measurements in a Jamaican population J. A. HAYES1 From the Pathology Department, University of the West Indies, Mona, Kingston 7, Jamaica Measurements of the gland thickness and Reid index have been made on bronchi obtained at necropsy on 53 male and 52 female Jamaicans. The mean values for the Reid index and mucous gland thickness obtained were 0-314 and 0O192 mm. for males, and 0-302 and 0l170 mm. for females respectively. No significant increase in value was seen with age, although the data suggest this trend. The results have been compared with data published from Montreal and the same overall Gaussian distribution is seen. This supports the suggestion that the gland measurements in non-bronchitic and bronchitic subjects do- not fall into two distinct groups but are part of a continuous distribution. The similarity of the two studies is also of interest as the populations are drawn from two distinct environments, one from a non-industrialized tropical island, the other from a large city in the northern hemisphere. Bronchial mucous gland enlargement is usually The existing evidence, therefore, indicates that associated with the consistent production of atmospheric pollution is connected with enlarge- copyright. mucoid sputum in chronic bronchitis (Reid, 1958). ment of bronchial mucous glands. It was suggested that this mucosal change could Clinical chronic bronchitis is encountered in be recognized by an increase in the ratio of Jamaica, apparently in the absence of atmospheric mucous gland thickness to thickness of the pollution (Walshe and Hayes, 1967). -
Dictionary of Epidemiology, 5Th Edition
A Dictionary of Epidemiology This page intentionally left blank A Dictionary ofof Epidemiology Fifth Edition Edited for the International Epidemiological Association by Miquel Porta Professor of Preventive Medicine & Public Health School of Medicine, Universitat Autònoma de Barcelona Senior Scientist, Institut Municipal d’Investigació Mèdica Barcelona, Spain Adjunct Professor of Epidemiology, School of Public Health University of North Carolina at Chapel Hill Associate Editors Sander Greenland John M. Last 1 2008 1 Oxford University Press, Inc., publishes works that further Oxford University’s objective excellence in research, scholarship, and education Oxford New York Auckland Cape Town Dar es Salaam Hong Kong Karachi Kuala Lumpur Madrid Melbourne Mexico City Nairobi Shanghai Taipei Toronto With offi ces in Argentina Austria Brazil Chile Czech Republic France Greece Guatemala Hungary Italy Japan Poland Portugal Singapore South Korea Switzerland Thailand Turkey Ukraine Vietnam Copyright © 1983, 1988, 1995, 2001, 2008 International Epidemiological Association, Inc. Published by Oxford University Press, Inc. 198 Madison Avenue, New York, New York 10016 www.oup-usa.org All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permission of Oxford University Press. This edition was prepared with support from Esteve Foundation (Barcelona, Catalonia, Spain) (http://www.esteve.org) Library of Congress Cataloging-in-Publication Data A dictionary of epidemiology / edited for the International Epidemiological Association by Miquel Porta; associate editors, John M. Last . [et al.].—5th ed. p. cm. Includes bibliographical references and index. ISBN 978–0-19–531449–6 ISBN 978–0-19–531450–2 (pbk.) 1.