MAY 2020 CATALOG MEDICATION CATALOG [email protected]

tailormadecompounding.com

1 859 887 0013

MEDICATION CATALOG

1 Table of contents

Our Story 4-5

Marketing Sheets 6-21 • Anti-Aging 7 • Growth Hormone 8-9 • Hormone Replacement Therapies 10-12 • Iontophoresis 13-15 • Sexual Dysfunction 16-18 • Weight Loss Pack 19 • Weight Loss 20-21

Medication Fact Sheets 22-54 • 3-Desoxy DHEA 24 • Amlexanox 25 • Apomorphine 26 • Bupropion/Naltrexone 27 • Danazol 28 • Dasatinib/Quercetin 29 • Dexamethasone Iontophoresis Patches 30 • Enclomiphene 31 • Ergoloid Mesylates 32 • Glycyrrhetinic Acid & Aminophylline 33 • KPV 34 • Ketamine 35 • Melanotan I 36 • Metformin + DHEA + Sermorelin 37 • NAD+ 38

2 • Nandrolone 39 • Oxytocin 40 • Pentosan Polysulfate 41 Pitolisant 42 • Phentermine/Topiramate 43 • PT-141 44 • Rapamycin 45 Scream Cream 46 • Sermorelin 47 • Sermorelin/ GLycine 48 • Stanozolol 49 • Thymosin Alpha-1 50 • Thymosin Beta-4 51 • Trimix 52 • Vitamin D 53 • Whitening Cream 54

IV Therapy 55-62 • IV Therapy Protocols 56-60 • Implementing IV Therapy in Your Practice 61-62

Price Lists: 63- • Capsules & Tablets 64-69 • Injections 70-73 • Creams & Foams 74-75 • Troches & Gummies 76-77 • Nasal & Eye Drops 77 • IV + Protocols 78-79

3 Our Story

Tailor Made Compounding was launched in the U.S. in January of 2016. We have since become a major contributor to peptide medicines in the integrative health space.

Through our compounding expertise, knowledge and experience, we have quickly grown as one of the top compounding pharmacies in the nation. Together, with our sister pharmacies around the world, we have established a reputation for working closely with our physicians and are well known for obtaining difficult to source and hard to compound pharmaceuticals. Our sister facility and first establishment, Como compounding in Melbourne, has been working with peptide therapies for over a decade. After witnessing the success these products were having for both doctors and patients in Australia, we saw the demand to bring our compounding expertise to the United States.

At Tailor Made, we pride ourselves in being partners with our practitioners and their staff. That’s why a major part of what we do involves educating our prescribers on the products we develop, including their clinical indications, and dosing. Through building these relationships and creating cutting-edge peptide therapies, we promise to maintain our status as leaders in the industry. Collectively, all of our locations work to support the same mission; To positively disrupt medicine using innovative technologies through education and partnership.

4 Positively disrupting medicine using innovative technology.

5 MARKETING SHEETS

6 ANTI-AGING PRODUCTS

Dasatinib- Dasatinib is a targeted therapy, classified as a signal transduction inhibitor, used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Dasatinib binds to and inhibits the growth-promoting activities of SRC-family protein-tyrosine kinases, which interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways.

Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence- associated secretory phenotype (SASP), accumulate with aging and at etiological sites in multiple chronic diseases. Senolytics, including the combination of Dasatinib and Quercetin, selectively eliminate senescent cells by transiently disabling pro-survival networks that defend them against their own apoptotic environment. In the first clinical trial of senolytics, Dasatinib + Quercetan improved physical function in patients with idiopathic pulmonary fibrosis (IPF), a fatal senescence-associated disease.

Product: Dasatinib 50mg capsule Protocol: Take 2 capsules by mouth daily for 3 days

Rapamycin (Sirolimus)- Rapamycin was initially discovered as an antifungal metabolite produced by Streptomyces hygroscopicus from a soil sample of Easter Island. This medication has been found to possess immunosuppressive and anti-proliferative properties in mammalian cells due to its ability to inhibit mTOR. Rapamycin is a potent inhibitor of antigen-induced proliferation of T cells, B cells, and antibody production. Interest in sirolimus as an immunosuppressive therapy in organ transplantation derives from its unique mechanism of action, its unique side-effect profile, and its ability to synergize with other immunosuppressive agents.Rapamycin’s immunosuppressive and anti-proliferative properties have led to its use in the prevention of organ transplant rejection. mTOR has been implicated in many of the processes that are associated with aging, including cellular senescence, immune responses, cell stem regulation, autophagy, mitochondrial function, and protein homeostasis (proteostasis). Furthermore, Product: Sirolimus 3mg capsule & Rapamycin’s inhibition of mTOR has been shown to regulate Sirolimus 0.001% cream in a 30mL cell senescence thus reducing it’s age-related pathology and Topi-CLICK® loss of function. This will ultimately improve physiological Protocol: Take 1 capsule by mouth once function and extend longevity. The downstream events that weekly. Apply a thin layer of cream follow the inactivation of TOR result in the blockage of topically to the face once daily. cell-cycle progression at the juncture of G1 and S phase.

Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | [email protected] 7 GROWTH HORMONE PRODUCTS

Growth hormone (GH) also known as human growth hormone (hGH) in its human form, is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals.GH stimulates production of IGF-1 and increases the concentration of glucose and free fatty acids.[1][2] GH is a 191-amino acid, single-chain polypeptide that is synthesized, stored and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland. When growth hormone is released from the pituitary gland, it signals the liver to release a second hormone, called insulin-like growth factor-1 (IGF-1). Together, growth hormone and IGF-1 tell the bones, muscles, and other organs and tissues to grow by adding more cells

Norditropin FlexPro Pen The FlexPro® pen is a delivery device that comes prefilled and preloaded.

5mg: $700.00 10mg: $1,300.00 15mg: $2,020.00

Did you know that GH can also help the immune system?

In mammals, the thymus supports maturation of thymocytes into T-cells and to maintain immunological tolerance. This is an important part of what makes your immune system work.

The thymus continually atrophies after childhood, it’s epithelia is replaced by adipose tissue, and it has been hypothesized that at least some immune dysfunction associated with aging is caused by the loss of thymus tissue. For example, infants whose thymus was removed during cardiac surgery at 18 years after surgery have immune cell populations more reminiscent of 65-70 year olds. Multiple factors have been tested preclinically to try and regenerate the Thymus. The thymic epithelia not only express GH receptors, but secrete GH in a positive feedback loop. By using growth hormone, you can regenerate the thymus and prevent immunosenescence!

8 Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | [email protected] GROWTH HORMONE PRODUCTS

Omnitrope Ready-to-use liquid cartridge eliminates the need to reconstitute or mix with a liquid

Injectable 5.8mg: $360.00

Saizen Saizen is a human growth hormone produced by recombinant DNA technology

5mg vial: $489.00

Zomacton Zomacton is a sterile, white, lyophilized powder, for subcutaneous use, after reconstitution with the 5mg: $348.00 accompanying diluent

Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | [email protected] 9 HORMONE REPLACEMENT THERAPIES

DHEA- DHEA is the most abundant hormone found in humans and is a precursor to many other steroids. DHEA declines steadily as we age, and low levels of DHEA have been associated with Alzheimer’s disease, cancer, and atherosclerotic disease. DHEA offers you an exciting option to help increase natural testosterone production.

Pricing: Benefits of DHEA: 25mg capsule $0.53 Helps boost testosterone, aids in immune support, promotes 50mg capsule $0.63 weight loss, enhances libido, improves sports performance and 100mg capsule $0.70 muscle mass. DHEA is also thought to slow the aging process and Suggested dosage: Take 1 combat bone density loss in women. capsule by mouth once daily

Thyroid- The thyroid gland secretes two hormones (triiodothyronine and thyroxine). These hormones are responsible for regulating basal metabolic rate, neurotransmitter production and release (e.g., dopamine, serotonin, norepinephrine), neural development, and it protects against arrhythmias (abnormal heartbeat). Many patients with clinical or subclinical hypothyroidism may experience symptoms such as fatigue/lethargy, depression, memory loss, anxiety, constipation, dry skin and hair, cold sensitivity, insomnia, and unexplained weight gain or inability to lose weight. Given these factors, a combination of both T3 and T4 is often essential for thyroid optimization. Custom liothyronine and levothyroxine compounded formulations are available in addition to the commercial options.

Benefits of Thyroid: Improves energy, aids in weight loss, better tolerance to temperature changes, better sleep, improved skin tone, decrease water retention, normalized bowel movements, resolve body aches, improve memory, reduce anxiety and depression.

Pricing: Armour 15mg tablet $0.90 Armour 30mg tablet $0.90 Armour 60mg tablet $1.00 Armour 90mg tablet $1.20 Armour 120mg tablet $1.60 Armour 180mg tablet $1.60 NP 15mg tablet $0.60 NP 60mg tablet $0.75 Suggested dosage: Take 1 tablet by mouth daily

10 Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | [email protected] HORMONE REPLACEMENT THERAPIES

Progesterone-

Progesterone is a steroid sex hormone prominently produced by the ovaries. It is of the steroid hormone class progestogens and is Progesterone is available in both the most abundant and important progestogen in the creams, capsules, and troches. human body. Progesterone plays a prominent role in pregnancy, embryonic development, and the menstrual cycle. Suggested dosage: as prescribed by your healthcare professional.

Benefits of Progesterone: Amplify effects of estrogen, enhance libido, improve thyroid function, neuroprotection, increase metabolic rate to help utilize fat, improve thyroid function, reduce anxiety and upregulation on GABA, reduce blood pressure and risk of breast cancer and help to reduce cholesterol

Testosterone- For males: Traditionally, we understand testosterone as being responsible for the For females: Testosterone is also vitally important for development of male tissues. It plays a females. There are several causes of low testosterone in significant role in bone and muscle mass, body women, often related to menopause & perimenopause. hair growth, and causes a deepened voice due That said, women may also experience low testosterone to increased tension on the vocal cords. For secondary to estrogen dominance, childbirth, cancer men, testosterone can reduce the risk of heart treatment, adrenal fatigue, use of birth control pills, attack, stroke, cognitive dysfunction, sarcopenia, depression, endometriosis, and statin drugs. For females, obesity, fatigue, depression, inflammation, testosterone replacement therapy has been shown to cancer, diabetes, and sexual dysfunction. increase libido, emotional well-being, muscle mass, pain tolerance, and neurotransmitter production. Additionally, it aids in memory retention, keeps skin from sagging, Testosterone available in creams, reduces body fat, & maintains bone density. troches, & injections Suggested dosage: as prescribed by your healthcare professional

Estrogen-

Estradiol (E2) is a naturally occurring and bioidentical estrogen, or an agonist of the estrogen receptor, the biological target of estrogens like endogenous estradiol. Due to it’s estrogenic activity, estradiol has antigonadoptric effects and can inhibit fertility and suppress sex hormone production in both women and men. It’s an estrogen and is used mainly in menopausal hormone therapy and to treat low sex hormone levels in women. It can be used in hormonal birth control for women and in the treatment of hormone- sensitive cancers like prostate cancer in men and breast cancer in women, among other uses.

Estrogen combinations available in creams (Estradiol, estriol, bi-est), tablets, or injections

Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | [email protected] 11 HORMONE REPLACEMENT THERAPIES

Enclomiphene-

Enclomiphene, an estrogen receptor antagonist, can be used in Pricing: the treatment of male hypogonadism. Enclomiphene is a 12.5mg capsule $0.97 nonsteroidal selective estrogen receptor modulator (SERM) and 25mg capsule $1.25 acts by increasing the gonadal production of testosterone while 25mg veggie dye free capsule $1.25 stimulating FSH and LH. Enclomiphene has the potential to improve metabolic profiles. Suggested dosage: Take 1 tablet by mouth daily

Benefits of Enclomiphene: Enclomiphene has been shown to increase testosterone levels while stimulating FSH and LH production. Studies have demonstrated that enclomiphene maintains the androgenic benefit of clomiphene citrate without the undesirable effects attributable to zuclomiphene

Oxandrolone-

Oxandrolone is a synthetic steroid, similar to the naturally occurring steroid testosterone. Oxandrolone is indicated as adjunctive therapy to promote weight gain after weight loss following extensive surgery, chronic infections, or severe trauma. It can also be used to offset the protein catabolism associated with prolonged administration of corticosteroids and for the relief of bone pain frequently accompanying osteoporosis.

Pricing: 5mg capsule $3.00 Benefits of Oxandrolone: 10mg capsule $3.20 Weight gain, increased lean muscle 15mg capsule $3.20 mass, decreased bone pain in patients 20mg capsule $3.20 who suffer from osteoporosis 25mg capsule $3.20 2.5mg troche $1.10 5mg troche $1.10

Suggested dosage: Take 1 capsule daily

12 Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | [email protected] IONTOPHORESIS PRODUCTS

Iontophoresis is a process of transdermal drug delivery by use of a voltage gradient on the skin. Molecules are transported across the stratum corneum by electrophoresis and electroosmosis and the electric field can also increase the permeability of the skin. This can help make many molecules permeable to the skin which previously were only available through injections. The products below are some of the most successful to be used in when delivered as transdermal patches.

NAD+ NAD+ is the second most popular cofactor in the human body. Anti-aging therapies becoming more mainstream as aging is now more often being viewed as a disease. Now that this transition is happening, the ability for NAD+ to activate PARPS, Sirtuins, and help with immune dysregulation has been thoroughly investigated and NAD+ and its precursors have been highly popularized.

The clinical importance of maintaining cellular NAD+ levels was established early in the last century with the finding that pellagra, a disease characterized by diarrhea, dermatitis, dementia and death, could be cured with foods containing the NAD+ precursor niacin. Additionally, cellular concentrations of NAD+ have been shown to decrease under conditions of increased oxidative damage such as occur during aging

Altered levels of NAD+ have been found to accompany several disorders associated with increased oxidative/free radical damage including diabetes, heart disease, age-related vascular dysfunction, ischemic brain injury, misfolded neuronal proteins, and Alzheimer’s dementia .

Interventions targeted at restoring NAD+ have been shown in animal models to support healthy aging and improve metabolic function, and dementia as well.

This is available as a supplement which can be prescribed with the Activa patches!

Dexamethasone The most popular and well researched iontophoresis application is the use of dexamethasone, a corticosteroid in a sodium phosphate solution. In this form, the drug is composed of negatively charged ions of dexamethasone phosphate and, when loaded into a negatively charged reservoir or electrode pad, the electrical force of the like charges pushes the medication molecules into the desired area. This causes pain relief for many hours via direct application.

KPV Methylene Blue KPV is a fragment of Alpha-MSH which has Methylene blue has many anti-inflammatory and shown some incredible anti-inflammatory anti-oxidant properties. It has been shown to capabilities. This is able to be driven across the activate SIRT1, help with skin apperance, and even skin to help with healing, inflammatory help with immune function. conditions, and psoriasis.

Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | [email protected] 13 IONTOPHORESIS PRODUCTS

The following table shows some other popuar uses of iontophoresis. If you have any questions about these applications please give us a call!

Medication Principal Indication(s) Treatment Rationale Iontophoresis

Acetic acid Calcific tendinitis Acetate is believed to increase 2%–5% aqueous solution from solubility of calcium deposits negative pole in tendons and other soft tissues Calcium chloride Skeletal muscle spasms Calcium stabilizes excitable 2% aqueous solution from membranes; appears to positive pole decrease excitability threshold in peripheral nerves and skeletal muscle Dexamethasone Inflammation Synthetic steroidal 4 mg/mL in aqueous solution anti-inflammatory agent from negative pole

Hydrocortisone Inflammation Anti-inflammatory steroid 0.5% ointment from positive pole

Hyaluronidase Local edema (subacute Appears to increase Reconstitute with 0.9% sodium and chronic stage) permeability in connective chloride to provide a 150 tissue by hydrolyzing mcg/ml solution from positive hyaluronic acid, thus pole decreasing encapsulation and allowing disbursement of local edema Iodine Adhesive capsulitis and other Iodine is a broad-spectrum 5%–10% solution or ointment soft-tissue adhesions; antibiotic, hence its use in from negative pole microbial infections infections, etc.; the sclerolytic actions of iodine are not fully understood Lidocaine Soft-tissue pain and Local anesthetic effects 4%–5% solution or ointment inflammation (e.g., bursitis, from positive pole tenosynovitis)

Magnesium sulfate Skeletal muscle spasms; Muscle relaxant effect may be 2% aqueous solution or myositis caused by decreased ointment from positive pole excitability of the skeletal muscle membrane and decreased transmission at the neuromuscular junction

Salicylates Muscle and joint pain in acute Aspirin Like drugs with 10% trolamine salicylate and chronic conditions (e.g., analgesic and ointment or 2%–3% sodium overuse injuries, rheumatoid anti-inflammatory effects salicylate solution from arthritis) negative pole

Tolazoline hydrochloride Indolent cutaneous ulcers Increases local blood flow and 2% aqueous solution or tissue healing by inhibiting ointment from positive pole vascular smooth muscle contraction

Zinc oxide Skin ulcers; other Zinc acts as a general 20% ointment from positive dermatologic disorders antiseptic; may increase tissue pole healing

14 Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | [email protected] ActivaPatch® IontoGoTM 4.0

A INSTRUCTIONS FOR TREATMENT

1. Open pouch and remove contents: (1) ActivaPatch® IontoGoTM 4.0; (1) alcohol wipe

2. Inspect area where ActivaPatch® IontoGoTM 4.0 is to be paced and ensure skins intact. Clean treatment site with alcohol and wipe thoroughly.

3. Ensure that treatment site is dry before applying ActivaPatch® IontoGoTM 4.0. B

4. With a marked syringe, draw 2.0 cc of ionic solution and hydrate the active Pull ionic solution reservoir (see diagram A).

5. Do not under- or overfill the reservoir.

6. Note: Make sure that there are no visible dry spots. If dry spots are visible, touch up lightly with tip of syringe until they are gone (do not overfill).

7. Gently apply your thumb to the battery case and remove the pull tab to C activate the patch (see diagram B).

8. Peel liner and pace patch directly on treatment area (see diagram C). Do not compress the electrode on reservoir area, or solution may leak.

9. Once treatment has begun, pull off remaining release liner over pull tab (see diagram D).

10. After 4 hours, remove patch. D 11. Properly dispose of electrode after use.

Peel Average treatment time for 80mAmp* dosage is 4 hours.

EACH BOX CONTAINS: x6 x6 x6 - (6) ActivaPatch® IontoGoTM 4.0 patches

ALCOHOL WIPE - (6) Alcohol Wipes

- (6) Syringes

15 SEXUAL DYSFUNCTION

Wanting something beyond Tadaafil? Have you tried Apomorphine? Whether you’re a male or female looking for a more spontaneous and natural sexual experience our novel approach may be exactly what you’ve been looking for.

Apomorphine is a dopaminergic agonist with affinity for dopamine receptor sites, mostly D(2), within the brain known to be involved in sexual function. It enhances normal neurological signaling in sexual response. It stimulates dopamine receptors in the hypothalamus, causing neural signals that relax smooth muscle and allowing erections to happen more easily.

Like Apomorphine, Tadalafil is a proven ED medication and its effects are cumulative and improve with daily use. For females, Tadalafil orally can be effective to increase sexual desire, sexual arousal, sexual orgasm and sexual satisfaction. It not only increases nitric oxide in the corpus cavernosum of men, but in women it also results in the relaxation of clitoral and vaginal smooth muscle and increased blood flow in these sites, a normal step in arousal and necessary to achieve orgasm.

Apomorphine with Tadalafil is often the perfect combination for both men and women to experience a spontaneous and natural sexual encounter. Apomorphine is effective in 43% of men who don't respond to tadalafil alone. Daily use allows sexual activity to happen any time, without needing to wait for a pill to start working.

Apomorphine - 2mg troche $2.00 Tadalafil / Apomorphine - 20mg/4mg troche $4.15 Tadalafil / Apomorphine - 40mg/4mg troche $4.15 Tadalafil / Apomorphine - 20mg/6mg troche $4.15

16 Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | [email protected] SEXUAL DYSFUNCTION

TMC Options to Overcome Sexual Dysfunction

Tadaafil Tadalafil is a proven ED medication and its effects are cumulative and improve with daily Available dosing: use. It’s effective for both male and - 5mg capsule $1.25 females.Tadalafil orally can be effective to - 10mg capsule $1.50 increase sexual desire, sexual arousal, sexual - 20mg capsule $1.75 orgasm and sexual satisfaction. It not only - 6mg gummy $2.50 increases nitric oxide in the corpus cavernosum of men, but in women it also results in the relaxation of clitoral and vaginal - Tadalafil 40mg/oxytocin 125iu $3.00 smooth muscle and increased blood flow in - Tadalafil 10mg/oxytocin 100iu/PT-141 1000mcg troche $3.25 these sites, a normal step in arousal and - Tadalafil 10mg/oxytocin 100iu/PT-141 2000mcg troche $4.00 necessary to achieve orgasm. - Tadalafil 20mg/oxytocin 100iu/PT-141 2000mcg troche $4.50

Sildenafil

Sildenafil is used to treat men who have erectile dysfunction (also called sexual impotence). Sildenafil belongs to a group of medicines called Available dosing: phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an - 100mg tablet $5.00 enzyme called phosphodiesterase type-5 from working too quickly. The - 150mg troche $4.00 penis is one of the areas where this enzyme works. By controlling the enzyme, sildenafil helps to maintain an erection after the penis is stroked.

Oxytocin

While Oxytocin certainly lives up to its reputation as the “Love Hormone,” it also has broader applications like weight management Available dosing: - 20 IU sublingual troche $1.00 and a performance enhancer. Oxytocin levels reach extreme levels - 50 IU sublingual troche $1.25 during childbirth and breastfeeding, however they have also found to - 100 IU sublingual troche $1.50 be elevated during sexual arousal, skin to skin contact, and orgasm. Due - 20 IU nasal spray $67.50 to this, research has been conducted and shown that exogenous - Oxytocin drops 24iu/0.1 10ml $75.00 administration of Oxytocin can improve libido, orgasm - Oxytocin drops 100iu/0.1 10ml $100.00 intensity/frequency and sexual pleasure.

Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | [email protected] 17 SEXUAL DYSFUNCTION

PT141 NOW avaiƒable in intranasal formuƒation Bremelanotide PT 141 is a very exciting drug which is frequently used by both men and women. It works on the central nervous system to directly induce an increase in libido and induce erections. It works in 80% of men who don't respond to PDE5 inhibitors and most will Available dosing: now use it as a first line therapy. The results 10000 mcg/mL 2mL sterile injectable $115.00 with women are much less objective but there 2.5mg/0.1mL Nasal spray 3mL $150.00 is far more research showing its success. It is FDA approved for women and is known to increase sexual gratifying experiences by 50%.

Trimix NOW avaiƒable in transdermal gel

Trimix is also used for sexual function. It is an intracavernosal three-drug injectable prescribed medication used to treat erectile dysfunction. This is most useful for men who cannot take oral medication or for those for which oral medication has not been shown effective.

Available dosing: - Alprostadil/Papaverine/Phentolamine 60mcg/30mg/3mg/mL 3mL: $50.00 Inject 0.02-0.04ml(max 0.08ml) into the base of the penis as needed for sexual activity - Transdermal Gel: Alprostadil/Papaverine/Phentolamine 10mg/30mg/0.5mg 15mL topiclick applicator $135.00 0.5ml- 1mL applied to the base of the penis 30 minutes prior to sexual activity

Scream Cream This is a topical cream made of l-Citrulline, Aminophylline, Ergoloid Mesylate, and Pentoxifylline. The primary mechanism of action is substantial vasodilation to the area of application which increases sensitivity. It has been reported that only ~25% of women achieve orgasm from sexual intercourse, and even with clitoral stimulation that number only increases to 43%. Women have reported adding Scream Cream significantly increased libido, intensity of orgasm, and also vaginal lubrication.

Available dosing: Citrulline 120mg/ml, Aminophylline 30mg/ml, Ergoloid Mesylate 0.5mg/ml, Pentoxifylline 50mg/ml 5mL syringe- $20.00 Dosage: Apply up to 0.5mL to clitoris 30 minutes prior to sexual activity

18 Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | [email protected] WEIGHT LOSS PACK

Have you heard about the NEW Sermorelin / Glycine Combo Pack? Get to your goal faster with the TMC Weight Loss Pack

Sermorelin is a synthetic hormone peptide similar in structure to a growth hormone releasing hormone (GHRH). It’s commonly utilized to optimize growth hormone levels in adults, offering a variable IGF-1 increase. Sermorelin works to burn fat, increase lean muscle, improve hormonal balance, enhance energy and boost the immune system by stimulating the production and release of hormones by the pituitary.

Glycine plays an important role in the control of hypothalamic-pituitary function, specifically impacting growth hormone release. Glycine is an amino acid that acts as a stimulatory agent inducing the pituitary gland to secrete hGH. Together, Sermorelin and Glycine make the ideal synergistic combination. The benefits of Glycine go far beyond encouraging weight loss and enhancing lean muscle mass. Enjoy a better night's sleep, less daytime fatigue, enhance mental clarity/cognition, significantly improved skin elasticity, tone and texture, while recieving an enhanced synergistic boost to IGF1.

Product: Sermorelin 2000mcg/Glycine 5mg/mL 4mL Protocol: 0.2mL subcutaneous injection, 5 of 7 nights a week. Taken 90 minutes after ‚ast caloric intake.

Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | [email protected] 19 WEIGHT LOSS PRODUCTS

There are many ways to address fat loss. Some of these ways include increasing insulin sensitivity, reducing appetite, increasing metabolism, and increasing utilization of fat stores Below we will detail the ways each of these products can assist with fat loss.

Increasing metabolism Sermorelin/Glycine: Sermorelin works to burn fat by stimulating the production and release of hormones by the pituitary. Glycine plays an important role in the control of hypothalamic-pituitary function, specifically impacting growth hormone release. Together, Sermorelin and Glycine make the ideal synergistic combination to increase IGF1 and help your body to burn fat.

Increasing insulin sensitivity: Amlexanox has been shown to selectively inhibit TBK1 and IKK-ε, producing reversible weight loss and improved insulin sensitivity. It is through this mechanism that it has produced substantial results in terms of reducing HbA1C levels and increasing insulin sensitivity.

Tetradecylthioacetic Acid, otherwise known as TTA, is a PPAR-alpha activator. PPAR-alpha is a transcription factor and a major regulator of lipid metabolism in the liver. PPAR-alpha is activated under conditions of energy deprivation and is nec essary for the process of ketogenesis, a key adaptive response to prolonged fasting. Activation of PPAR-alpha promotes uptake, utilization, and catabolism of fatty acids by upregulation of genes involved in fatty acid transport, fatty acid binding and activation, and peroxisomal and mitochondrial fatty acid. β-oxidation. The clearing of fat from the blood causes a drop in lipoproteins and a lowering of LDL cholesterol. TTA has also been shown to decrease blood pressure and exert a mild anti-oxidant effect.

Amlexanox in combination with Tetradecylthioacetic has shown to work synergistically through increased insulin sensitivity and fat mobilization/uptake/catabolism to aid in weight loss, weight loss maintenance, and improving total cholesterol levels.

Liraglutide is an analog of human GLP-1 and acts as a GLP-1 receptor agonist. Liraglutide increases intracellular cyclic AMP (cAMP) leading to insulin release in the presence of elevated glucose

20 Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | [email protected] WEIGHT LOSS PRODUCTS

Decreasing appetite Oxytocin for weight management has been shown to decrease overall weight through reduced caloric consumption in both animal and human models. Data suggests this is done by modulating the activation of hedonic food motivation pathways. The ventral tegmental area (VTA) is one part of this pathway and the origin of dopaminergic bodies. The VTA also has oxytocin receptors, and it is believed that saturating these receptors with exogenous oxytocin administration is what leads to the downstream effect of decreased food desire.

Phentermine increases release of neurotransmitters which simulate metabolism and suppress appetite. Phentermine is a “sympathomimetic” because it simulates the release and inhibition of certain neurotransmitters in your brain, specifically dopamine and norepinephrine. Essentially it tricks your mind into feeling full

Bupropion/Naltrexone is a novel weight loss drug that combines a noradrenaline/dopamine reuptake inhibitor with a non-selective opioid receptor antagonist. Research on the pathways that regulate food intake and body weight has identified the hypothalamic melanocortin system and the mesolimbic reward system, which are the targets of this combination.

Phentermine/Topiramate- Phentermine is a noradrenergic drug, which is theorized to affect food intake primarily via the enhancement of norepinephrine release and possibly via the blockade of norepinephrine reuptake as well. Topiramate has been shown to exhibit weight loss with a reduction in visceral body fat. Topiramate acts via modification of excitatory voltage-activated sodium and calcium channels, antagonism AMPA/KA receptors, and enhancement of gamma-aminobutyric acid receptor-mediated inhibitory currents. Among these actions, decreased calorie intake appears to be a significant factor associated with topiramate-induced weight loss in humans

Increasing utilization of fat MIC B12 L-Carnitine 25/50/50/1/50mg/ml 10mL injectable

Methionine, an essential amino acid, helps the liver breakdown fats, lowers cholesterol, relieves fatigue and helps allergies by lowering histamine release. Inositol, a B vitamin, helps the breakdown of fats, lowers cholesterol, and helps control mood and appetite. Choline, an essential nutrient, helps the liver breakdown fats and excrete toxins. B12, a vitamin that boosts energy and overall metabolic rate, assists in the burning of stored body fat, helps detox, and helps regulate sleep, mood, and appetite. The addition of L-Carnitine will assist in converting body fat to fuel and elevate certain enzymes needed to metabolize sugars, starches, and other carbohydrates. It is used to facilitate fatty acid oxidation, aiding in the reduction of body fat, both systemically and site specifically.

Fat Loss Cream (Aminophylline/Glycyrrhetinic acid) Aminophylline and glycyrrhetinic acid transdermal cream is used for fat loss. Aminophylline and glycyrrhetinic prevent cAMP breakdown. Cyclic AMP (cAMP) functions in several biochemical processes including the regulation of glycogen, sugar, and lipid metabolism. cAMP works by activating protein kinase A (PKA) which assists in glycogen, sugar, and lipid metabolism. Aminophylline has displayed topical fat reduction from the waist. Aminophylline and glycyrrhetinic acid fat loss cream yields the best results through topical application.

GOAL (Glutamine, Ornithine, Arginine and Lysine) GOAL is an amino acid blend which is commonly utilized for weight loss and endurance. Glutamine improves immunity, aids in cellular repair, healing, and intestinal health. Ornithine helps to manage fatigue by stabilizing energy levels and promoting better sleep. It’s utilized to reduce fatigue and improve measures of athletic performance such as speed, strength, and power in some people. Also, taking ornithine in combination with arginine seems to improve strength and power in male weightlifters. Arginine is known to support blood vessel tone and boost nitric oxide levels. While Lysine together with its fatty acids helps to burn calories, thus giving the body a necessary source of energy. Lysine as an amino acid may boost the energy levels, promote weight loss process and support the digestive system. This combination is often the power punch patients are looking for to improve overall health while improving body composition encouraged by improved metabolic function resulting in weight loss.

Tailor Made Compounding Pharmacy | Ph: 1 859 887 0013 | Fax: 1 859 406 1242 | [email protected] 21 MEDICATION FACT SHEETS

22 Our fact sheets contain the following for each product:

Description Protocol

Clinical Research

23 3-DESOXY DHEA

Purity: >98% (HPLC on request) 3-Desoxy DHEA is a competitive aromatase inhibitor for use in controlling estrogen Molecular Formula: and increasing endogenous testosterone production. This compound is shown to potently reduce aromatase activity through binding to the enzyme and blocking R1=H, R2=CH3 access to endogenous estrogen precursors (androstenedione, testosterone). The competitive inhibition offers a more short term solution to estrogen control, as Molecular Weight: aromatase inhibition only occurs while 3-Desoxy DHEA is present in the body. 288.43 g/mol 3-Desoxy DHEA is a relatively quickly metabolized compound and has an excellent potency with IC50 and Ki values. 3-Desoxy DHEA offers you a new option for Sequence: estrogen control and natural testosterone elevation along with a high potency Non-peptide coupled with better dose control.

PROTOCOL: Content & Potency: 100mg capsules provided in a quantity of 30. Suggested dosage: Take 1 capsule by mouth once daily.

CLINICAL RESEARCH: What is desoxy-DHEA and How Does it Work?

Although Desoxy DHEA is an effective competitive inhibitor of aromatase it is not nearly as potent as SERMs or other steroidal and non-steroidal suicide inhibitors. The structure- activity relationships mentioned are notcompre- hensive as there undoubtedly exists additional structural manipulations that occur to further enhance aromatase anity. Therefore, it is NOT an appropriate replacement to prescription compounds when heavy aromatase inhibition is required. It does however, offer a cost-effective, safe, and legal method of estrogen management as validated by independent lab tests and selected in vitro data. Competitive aromatase inhibition works differently than suicide substrate inhibition, which is the mode of action through which other over the counter aromatase inhibitors such as 6-OXO and ATD work. Competitive inhibition offers a more short term solution to estrogen control, as aromatase inhibition only occurs while Desoxy DHEA is present in the body. Desoxy DHEA is a relatively quickly metabolized compound. So with Desoxy DHEA Tailor Made offers you a new option for estrogen control.

Ben Esgro, BS,CSCS,CIS

24 AMLEXANOX

Purity: >98% (HPLC on request)

Molecular Formula: C H N O 16 14 2 4 Amlexanox is an anti-inflammatory and anti-allergic compound which has Molecular Weight: traditionally been used to treat ulcers by reducing healing time and pain. It has multiple mechanisms of action such as inhibiting inflammation by inhibiting the 298.3 g/mol release of histamine and leukotrienes. It has been shown to selectively inhibit TBK1 and IKK-ε, producing reversible weight loss and improved insulin sensitivity. It is Sequence: through this mechanism that it has produced substantial results in terms of Non-peptide reducing HbA1C levels and increasing insulin sensitivity.

PROTOCOL: Content & Potency: 40mg capsules provided in a quantity of 90. Suggested dosage: Take one capsule by mouth 3 times daily.

CLINICAL RESEARCH: Inhibition of IKKε and TBK1 improves glucose control in a subset of patients with type 2 diabetes.

Numerous studies indicate an inflammatory link between obesity and type 2 diabetes. The inflammatory kinases IKKε and TBK1 are elevated in obesity; their inhibition in obese mice reduces weight, insulin resistance, fatty liver and inflammation. Here we studied amlexanox, an inhibitor of IKKε/TBK1, in a proof-of-concept randomized, double blind, placebo-controlled study of 42 obese patients with type 2 diabetes and nonalcoholic fatty liver disease. Treatment of patients with amlexanox produced a statistically significant reduction in Hemoglobin A1c and fructosamine. Interestingly, a subset of drug responders also exhibited improvements in insulin sensitivity and hepatic steatosis. This subgroup was characterized by a distinct inflammatory gene expression signature from biopsied subcutaneous fat at baseline. They also exhibited a unique pattern of gene expression changes in response to amlexanox, consistent with increased energy expenditure. Together, these data suggest that IKKε/TBK1 inhibitors may be effective therapies for metabolic disease in an identifiable subset of patients.

Oral, Elif A et al. “Inhibition of IKKε and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes.” Cell metabolism 26 1 (2017): 157-170.e7 .

25 APOMORPHINE

Purity: >98% (HPLC on request)

Molecular Formula:

C17H17NO2

Molecular Weight: Apomorphine is a dopaminergic agonist with affinity for dopamine receptor sites, mostly D(2), within the brain known to be involved in sexual function. Apomorphine 267.32 g/mol induces selective activation in the nucleus paraventricularis leading to erectogenic signals. It exerts its effect on hypothalamic centres involved in the triggering of the Sequence: erection cascade. It dissolves rapidly and results in an erection in responders in Non-peptide approximately 20 min.

PROTOCOL: Content & Potency: Troche 2mg Suggested Dosage: Dissolve 1 troche under the tongue for 15 minutes before desired effect.

CLINICAL RESEARCH: Oral treatment of erectile dysfunction with apomorphine SL.

Apomorphine SL (Ixense, Uprima) is a new oral medication shown to be effective in the treatment of erectile dysfunction. This compound is a dopaminergic agonist with affinity for dopamine receptor sites - mostly D(2) - within the brain known to be involved in sexual function. Apomorphine induces selective activation in the nucleus paraventricularis leading to erectogenic signals. More than 5,000 men with erectile dysfunction participat- ed in phase II/III clinical trials assessing the safety and efficacy of doses ranging from 2 to 6 mg. The most favorable risk/benefit ratio is seen with a dose-optimization regimen of 2-3 mg: the 3-mg dose provides efficacy comparable to that of 4 mg but with fewer side effects. Consequently, review of clinical studies focuses on data with the 2- to 3-mg dose, the registered dose for use in clinical practice. The primary efficacy endpoint in most clinical trials with apomorphine SL was the percentage of attempts resulting in erections firm enough for intercourse - one of the most rigorous endpoints used in ED trials to date. These data were collected from both patients and their partners by reviewing entries in patient diaries and partner BSFI questionnaires. Secondary endpoints included percentage of attempts resulting in intercourse and improvement in ED severity based on the International Index of Erectile Function (IIEF). The proportion of attempts resulting in erections firm enough for intercourse was 49.4% with 3 mg compared with the baseline value of 24.3%. Partner evaluations corresponded with those of the patients. Erections occurred between 18 and 19 min after taking apomorphine SL 2 or 3 mg. The most common side effect was nausea which declined with continued use. Vasovagal syncope was reported in <0.2% of men, and was preceded by clear prodromal symptoms. Thus, apomorphine SL is an effective, well-tolerated drug for erectile dysfunction. Altwein JE1, Keuler FU.

26 BUPROPION/NALTREXONE

Purity: Bupropion/Naltrexone is a novel weight loss drug that combines a noradrenaline/dopamine reuptake inhibitor with a non-selective opioid receptor antagonist. Research on the pathways >99% (HPLC on request) that regulate food intake and body weight has identified the hypothalamic melanocortin system and the mesolimbic reward system, which are the targets of this combination. Molecular Formula: Pro-opiomelanocortin (POMC)-producing neurons in the hypothalamus release melanocyte- stimulating hormone (MSH) and beta-endorphin. MSH mediates the anorectic Bupropion: C13H18ClNO effect of POMC, whereas beta-endorphin is responsible for autoinhibitory feedback, which Naltrexone: C20H23NO4 inactivates the anorectic effect. Bupropion can be used to stimulate the POMC neurons, whereas naltrexone can be used to block the autoinhibitory feedback that is associated with Molecular Weight: a decline in weight reduction. The combination’s mechanism of action might also regulate Bupropion: 239.74 g/mol the mesolimbic reward pathways, which may lead to further weight reduction by modulating Naltrexone: 341.4 g/mol reward values and goal-oriented behaviors. Bupropion/Naltrexone has a well-studied safety and tolerability profile. Three long-term (56 weeks) studies have shown that patients who add Sequence: contrave lose approximately 2 to 4 times more weight than with diet and exercise alone. In one study, patients who also participated in an intensive diet and exercise program for a full Non-peptide year lost 25 pounds on average.

PROTOCOL: Content & Potency: 180mg/12mg Capsule, 90mg/8mg Capsule, 90mg/6mg Capsule Suggested dosage: The dosing of bupropion/naltrexone must be titrated. Starting with 90mg/6mg per day, increasing over four weeks to 180mg/12mg twice daily

CLINICAL RESEARCH: Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, ran- domised, double-blind, placebo-controlled, phase 3 trial. Despite increasing public health concerns regarding obesity, few safe and effective drug treatments are available. Combination treatment with sustained-release naltrexone and bupropion was developed to produce complementary actions in CNS pathways regulating bodyweight. The COR-I study assessed the effect of such treatment on bodyweight in overweight and obese participants. 1742 participants were enrolled and randomised to double-blind treatment (naltrexone 32 mg plus bupropion, n=583; naltrexone 16 mg plus bupropion, n=578; placebo, n=581). 870 (50%) participants completed 56 weeks of treatment (n=296; n=284; n=290, respectively) and 1453 (83%) were included in the primary analysis (n=471; n=471; n=511). Mean change in bodyweight was -1.3% (SE 0.3) in the placebo group, -6.1% (0.3) in the naltrexone 32 mg plus bupropion group (p<0.0001 vs placebo) and -5.0% (0.3) in the naltrexone 16 mg plus bupropion group (p<0.0001 vs placebo). 84 (16%) participants assigned to placebo had a decrease in bodyweight of 5% or more compared with 226 (48%) assigned to naltrexone 32 mg plus bupropion (p<0.0001 vs placebo) and 186 (39%) assigned to naltrexone 16 mg plus bupropion (p<0.0001 vs placebo). The most frequent adverse event in participants assigned to combination treatment was nausea (naltrexone 32 mg plus bupropion, 171 participants [29.8%]; naltrexone 16 mg plus bupropion, 155 [27.2%]; placebo, 30 [5.3%]). Headache, constipation, dizziness, vomiting, and dry mouth were also more frequent in the naltrexone plus bupropion groups than in the placebo group. A transient increase of around 1.5 mm Hg in mean systolic and diastolic blood pressure was followed by a reduction of around 1 mm Hg below baseline in the naltrexone plus bupropion groups. Combination treatment was not associated with increased depression or suicidality events compared with placebo. Greenway FL, Fujioka K, Plodkowski RA, Mudaliar S, Guttadauria M, Erickson J, Kim DD, Dunayevich E; COR-I Study Group.

27 DANAZOL

Purity: >99% (HPLC on request)

Molecular Formula: C H NO 22 27 2 Danazol is a prescription medication approved to help treat endometriosis and hereditary angioedema. It is also known to significantly decrease levels of sex Molecular Weight: hormone binding globulin (SHBG) and thereby increase the amount of free 337.5 g/mol testosterone. It’s thought that it does this by inhibiting the hepatic synthesis of SHBG on a dose dependent basis and may be accentuated by endogenous Sequence: androgen concentrations. Danazol has been shown to reduce levels of SHBG by up Non-peptide to 80% depending on the dose administered.

PROTOCOL: Content & Potency: 25mg, 50mg, 75mg, 100mg, 150mg capsule, 200mg capsule 50mg, 100mg, 150mg, 200mg troche Suggested dosage: Take 1 capsule/troche by mouth every day

CLINICAL RESEARCH: Changes in the SHBG concentration during danazol treatment. Serum levels of sex hormone binding globulin (SHBG) were measured before and during administration of danazol in daily doses varying between 200 and 800 mg for a period of 1-6 months. A rapid proportional decrease in SHBG was seen at all dose levels starting within the first 24 hours and reaching statistical significance by 48 hours. After approximately one month of treatment, the SHBG concentrations began to approach a new steady state at a level of approximately 20-30% of the original concentration, depending on the dose of danazol. The mean proportional reduction following a certain dose was almost identical in premenopausal and postmenopausal women. The findings of the present investigation suggest that danazol exerts a direct inhibitory effect on the hepatic synthesis of SHBG, which is dependent of the dose of danazol, independent of estrogen concentration, but possibly accentuated by endogenous androgens.

Acta Obstet Gynecol Scand Suppl. 1984;123:117-23.

28 DASATINIB/QUERCETIN

Purity: Dasatinib is a targeted therapy, classified as a signal transduction inhibitor, used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Dasatinib binds to and >98% inhibits the growth-promoting activities of SRC-family protein-tyrosine kinases, which interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Molecular Formula: Quercetin is a pentahydoxyflavone, one of the most abundant flavonoids found in our diet. It’s beneficial Dasatinib: C22H26ClN7O2S effects include antibacterial, anti-thrombotic, anti-inflammatory, and anti-neoplastic properties as well

Quercetin: C15H10O7 as acts as a protein kinase inhibitor. It is an excellent antioxidant that scavenges many naturally occurring reactive oxygen species, including O2- and ONOO−. It also facilitates zinc trafficking into cells, which in Molecular Weight: turn functions as an antioxidant. Dasatinib: 488.01 g/mol Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence- Quercetin: 302.23 g/mol associated secretory phenotype (SASP), accumulate with aging and at etiological sites in multiple chronic diseases. Senolytics, including the combination of Dasatinib and Quercetin, selectively eliminate Sequence: senescent cells by transiently disabling pro-survival networks that defend them against their own apoptotic environment. In the first clinical trial of senolytics, Dasatinib + Quercetan improved physical Non-peptide small molecule function in patients with idiopathic pulmonary fibrosis (IPF), a fatal senescence-associated disease.

PROTOCOL: Content & Potency: Dasatinib 50mg capsule & Quercetan 250mg capsule Suggested dosage: Dasatinib: Take 2 capsules by mouth daily for 3 days Quercetan: Take 4 capsules by mouth daily for 3 days

CLINICAL RESEARCH: Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease. Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases. Senolytics, including the combination of Dasatinib and Quercetin (D + Q), selectively eliminate senescent cells by transiently disabling pro-survival networks that defend them against their own apoptotic environment. In the first clinical trial of senolytics, D + Q improved physical function in patients with idiopathic pulmonary fibrosis (IPF), a fatal senes- cence-associated disease, but to date, no peer-reviewed study has directly demonstrated that senolytics decrease senescent cells in humans.D + Q reduced adipose tissue senescent cell burden within 11 days, with decreases in p16INK4A-and p21CIP1-expressing cells, cells with senescence-associated β-galactosidase activity, and adipocyte progenitors with limited replicative potential. Adipose tissue macrophages, which are attracted, anchored, and activated by senescent cells, and crown-like structures were decreased. Skin epidermal p16INK4A+ and p21CIP1+ cells were reduced, as were circulating SASP factors, including IL-1α, IL-6, and MMPs-9 and -12.

Hickson, LaTonya J et al. “Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.” EBioMedicine vol. 47 (2019): 446-456. doi:10.1016/j.ebiom.2019.08.069

29 DEXAMETHASONE IONTOPHORESIS PATCHES

Purity: Dexamethasone is a synthetic glucocorticoid that can provide multiple benefits via >99% its wide ranging immunosuppressant effects. To go along with its anti-inflammatory effect, dexamethasone also has an inhibitory effect through suppressing fibroblast Molecular Formula: DNA, RNA and protein synthesis. Studies have even shown that it can increase collagen synthesis. Iontophoresis is a process that allows transdermal transmission of C H FNa O P 22 28 2 8 medication by utilizing direct current to drive medication deeper into skin tissue. An ionic compound is placed on the like-charged electrode which leads to the Molecular Weight: repulsion needed to drive the medication away and across the skin barrier. 516.4 g/mol The combination of steroid medications and iontophoresis has been utilized for over 45 years. Studies have shown that the combination of 40-mA-min Sequence: iontophoresis with 0.4% Dexamethasone Sodium Phosphate achieves statistically Non-peptide significant absorption in human tissue. This protocol has been used for a plethora of different conditions, including: Achilles tendonitis, knee arthritis, capal tunnel syndrome, lateral epicondylitis, infrapatellar tendonitis, plantar fasciitis, myofascial syndrome and temporomandibular joint dysfunction. Also, because this medication is working locally on the tissue there is a much lower to no side effect profile when compared to oral/injectable corticosteroids. This is a great option for any patient undergoing connective tissue rehabilitation or arthritis.

PROTOCOL: Content & Potency: IonToGo Patches/Dexamethasone Package Bundle (6 patches, 6 x 2mL Dexamethasone Sodium Phosphate 0.4% syringes) Suggested dosage: Apply 1 patch to affected area once to twice weekly

CLINICAL RESEARCH: Absorption of dexamethasone sodium phosphate in human connective tissue using iontophoresis. Iontophoresis ostensibly facilitates the delivery of medications through the skin to underlying tissues using a direct electrical current. Dexamethasone is the most commonly used medication with iontophoresis to treat a variety of connective tissue disorders. RESULTS: There was a statistically significant difference in dexamethasone concentrations between the groups (P = .0216). Of the 16 samples in the TI group, 8 had measurable amounts of dexamethasone, with an average concentration of 2.906 ng/g of tendon tissue. In the SI group, 1 of the 13 samples had measurable amounts of dexamethasone with an average concentration of 0.205 ng/g of tendon tissue. The control samples contained no dexamethasone. CONCLUSIONS:Iontophoresis facilitates the transmission of dexamethasone to connective tissues in humans. Gurney AB, Wascher DC. Absorption of dexamethasone sodium phosphate in human connective tissue using iontophoresis. Am J Sports Med. 2008 Apr;36(4):753-9. doi: 10.1177/0363546507311597. Epub 2008 Jan 11. PubMed PMID: 18192495.

30 ENCLOMIPHENE

Purity: >98% (HPLC on request)

Molecular Formula: C H C NO 26 28 1 Enclomiphene is used in the process of treating male hypogonadism (lower function of the reproductive organs) and is a single isomer with pure estrogen antagonism. Molecular Weight: Enclomiphene is a non-steroidal selective estrogen receptor modulator (SERM) and 405.966 g/mol acts by increasing gonadotropin secretion and gonadal production of testosterone. Enclomiphene has the potential to help the reproductive status in men and improve Sequence: metabolic profiles. It is a single isoform of the more abundant clomiphene and has Non-peptide much fewer side effects.

PROTOCOL: Content & Potency: 25mg capsules provided in a quantity of 30. Suggested dosage: Take one capsule by mouth once daily.

CLINICAL RESEARCH: Enclomiphene citrate stimulates testosterone production while p-eventing oligospermia: a randomized phase II clinical trial comparing topical testosterone. Objective: To determine the effect of enclomiphene citrate in men with secondary hypogonadism.

Methods: iws randomized phase IIB study enrolled 124 men with a morning serum T level of <250 ng/dL on 2 occasions. e subjects were randomized to one of two doses of enclomiphene citrate (12.5-mg or 25-mg), 1% topical testosterone, or placebo. Hormone levels of LH, FSH, and T and seman levels were measured before, during and aer 3 months of treatment.

Results: A total of 113 men received 3 months of treatment, and 73 completed the study and provided both baseline and at least 1 seman sample at the end of the study. All 3 active treatment groups showed a significant increase in total testosterone level from baseline compared with placebo, with no statistically significant difference in testosterone levels found between the active treatment groups compared with placebo.

Wiehle RD, Fontenot GK, Wike J, et al. ZA-203 Clinical Study Group. Fertil Steril. 2014; 102(3): 720-727.

31 ERGOLOID MESYLATES

Purity: Ergoloid mesylates have an FDA approved indication for treating elderly patients >99% (HPLC on request) with symptoms of dementia. They are synthetically produced from a mixture of alkaloids derived from ergot, a fungus that grows on rye. Ergiloid mesylates block Sequence: the alpha-adrenoreceptors which produce vasodilation and increase blood and Non-peptide oxygen supply to the brain. Ergoloid mesylates have been shown to activate both D1 and D2 dopamine receptors as well as decrease brain levels of MAO.

The improvement in the dopamine system provides associated cognitive benefits and can also aid in treating depression and anxiety. Ergoloid mesylates have also been studied in hearing loss, sleep issues, migraines, and nerve damage.

PROTOCOL: Content & Potency: 1mg Tablet Suggested dosage: Take 1 tablet by mouth three to four times daily with food

CLINICAL RESEARCH: Ergoloid mesylates (‘Hydergine’) in the treatment of mental deterioration in the elderly: a 6-month double-blind, placebo-controlled trial A double-blind, placebo-controlled trial was carried out in 97 elderly patients with age-related mental deterioration to assess the efficacy of ergoloid mesylates in improving their symptoms. Patients were allocated at random to receive either 4.5 mg ergoloid mesylates per day or a matching placebo tablet and were followed-up for 6 months after the start of treatment. Clinical examinations were performed by the doctor, using the EACG rating scale (a French version of the Sandoz Clinical Assessment Geriatric scale), and by the nurse, using the NOSIE scale, when patients entered the trial and repeated after 2, 4 and 6 months. Changes in the factors (symptom groups) covered by these scales were subjected to statistical analysis. After 6-months’ treatment, a statistically significant difference in favour of the ergoloid mesylates group was observed for cognitive deficits (p less than 0.05), anxiety and mood depression (p less than 0.01), unsociability (p less than 0.01), retardation (p less than 0.05) and irritability (p less than 0.001). Treatment was very well tolerated. It was also observed that there was a progressive increase in efficacy throughout the trial; this indicates that treatment with ergoloid mesylates in patients with mental deterioration should be long-term. Rouy JM, Douillon AM, Compan B, Wolmark Y. Ergoloid mesylates (‘Hydergine’) in the treatment of mental deterioration in the elderly: a 6-month double-blind, placebo-controlled trial. Curr Med Res Opin. 1989;11(6):380-9. PubMed PMID: 2651014.

32 GLYCYRRHETINIC ACID & AMINOPHYLLINE

Glycyrrhetinic Acid:

Purity: Molecular Formula: Molecular Weight: Sequence:

>98% C30H46O4 470.69 g/mol Non-Peptide

Aminophylline:

Purity: Molecular Formula: Molecular Weight: Sequence:

>98% C16H24N10O4 420.43 g/mol Non-Peptide

Aminophylline and glycyrrhetinic acid transdermal cream is used for fat loss. Aminophylline and glycyrrhetinic prevent cAMP breakdown. Cyclic AMP (cAMP) functions in several biochemical processes including the regulation of glycogen, sugar, and lipid metabolism. cAMP works by activating protein kinase A (PKA) which assists in glycogen, sugar, and lipid metabolism. Aminophylline has displayed topical fat reduction from the waist. In a study examining aminophylline cream application, the reduction in waist circumference was significant for both men and women. Over a period of 12 weeks, participants in the study lost 11cm in waist circumference. In differentiated adipocytes, 18β-glycyrrhetinic acid increases the level of glycerol release and up-regulates the mRNA of hormone-sensitive lipase, adipose triglyceride lipase, and perilipin, as well as the phosphorylation of hormone-sensitive lipase. 18 β- glycyrrhetinic acid alters fat mass by directly affecting adipogenesis in maturing preadipocytes and lipolysis in mature adipocytes. Therefore, aminophylline and 18β-glycyrrhetinic acid may be useful for treating obesity. Both aminophylline and glycyrrhetinic acid combined effectively combat fat loss. Aminophylline and glycyrrhetinic acid fat loss cream yields the best results through topical application.

PROTOCOL: Content & Potency: Aminophylline/Glycyrrhetinic Acid 0.5%/2.5% transdermal cream provided in a 60ml pump applicator. Suggested dosage: Apply 1ml twice daily transdermally.

CLINICAL RESEARCH: 18β-Glycyrrhetinic acid inhibits adipogenic differentiation and stimulates lipolysis 18β-Glycyrrhetinic acid (18β-GA) obtained from the herb liquorice has various pharmacological properties including anti-inflammatory and anti-bacterial activities. However, potential biological anti-obesity activities are unclear. In this study, novel biological activities of 18β-GA in the adipogenesis of 3T3-L1 preadipocytes and in lipolysis of differentiated adipocytes were identified. Mouse 3T3-L1 cells were used as an in vitro model of adipogenesis and lipolysis, using a mixture of insulin/dexamethsone/3- isobutyl-1-methylxanthine (IBMX) to induce differentiation. The amount of lipid droplet accumulation was determined by an AdipoRed assay. The expression of several adipogenic transcription factors and enzymes was investigated using real-time reverse transcriptase- polymerase chain reaction (RT-PCR) and Western blotting. 18β-GA dose-dependently (1–40 lM) significantly decreased lipid accumulation in maturing preadipocytes. In 3T3-L1 preadipocytes, 10 lM of 18β-GA down-regulated the transcriptional levels of peroxisome proliferator-activated receptor c, CCAAT/enhancer-binding protein and adiponectin, which are markers of adipogenic differentiation via Akt phosphorylation. Also, in differentiated adipocytes, 18β-GA increased the level of glycerol release and up-regulated the mRNA of hormone-sensitive lipase, adipose TG lipase and perilipin, as well as the phosphorylation of hormone-sensitive lipase at Serine 563. The results indicate that 18β-GA alters fat mass by directly affecting adipogenesis in maturing preadipocytes and lipolysis in matured adipocytes. Thus, 18β-GA may be useful for the treatment of obesity. Moon, Myung-Hee et al. “18β-Glycyrrhetinic acid inhibits adipogenic differentiation and stimulates lipolysis.” Biochemical and biophysical research communications 420 4 (2012): 805-10

33 KPV

Purity: KPV (Lysine-Proline-Valine) is a C-terminal tripeptide fragment of α-melanocyte >99% (confirmed by HPLC) stimulating hormone (α-MSH). α-MSH stimulates the production and release of melanin by melanocytes in skin and hair, acting through melanocortin 1 receptor. Molecular Formula: Several studies have previously shown that KPV has decreased inflammation and tumorigenesis in the body. The KPV anti-inflammatory effect is PepT1-mediated in Ac-C H N O -NH 16 32 4 6 2 intestinal epithelial and immune cells. PepT1 is an oligopeptide transporter that is overexpressed in the colonic epithelial cells of chronic ulcerative colitis, which can Molecular Weight: deliver KPV into cytosol in the intestine. The tripeptide, KPV has significant 378.47 g/mol antimicrobial and anti-inflammatory properties especially in those with psoriasis. Psoriasis is a chronic autoimmune condition which causes the rapid build-up of Sequence: skin cells and is usually treated using hydrocortisone. In people with psoriasis, KPV Lys-Pro-Val has shown to limit symptoms of the condition including itchiness, dryness, redness, peeling, and more. Therefore, KPV could be used for an extended period of time without risking the unwanted complications of long term steroid therapy. KPV is a promising, therapeutic treatment for inflammatory bowel disease (IBD), colon cancer, and inflammatory skin disorders, in particular, psoriasis.

PROTOCOL: Content & Potency: 2mg/ml 5ml Suggested Dosage: Please inquire, variable dosing recommendations Content & Potency: 500mcg acid resistant capsule Suggested Dosage: One capsule by mouth daily Content & Potency: 30ml TopiClick at 15mg/ml Suggested dosage: 0.5ml applied to area twice daily

CLINICAL RESEARCH: Alpha-Melanocyte-Stimulating Hormone and Related Tripeptides: Biochemistry, Anti Inflammatory and Protective Effects in Vitro and in Vivo, and Future Perspectives for the Treatment of Immune-Mediated Inflammatory Diseases Alpha-MSH is a tridecapeptide derived from proopiomelanocortin. Many studies over the last few years have provided evidence That Alpha -MSH has potent protective and antiinflammatory effects. These effects can be elicited via centrally expressed melanocortin receptors that orchestrate descending neuro-genic antiinflammatory pathways. Alpha-MSH can also exert antiinflammatory and protective effects on cells of the immune system and on peripheral non immune cell types expressing melanocortin receptors. At the molecular level, Alpha-MSH affects various pathways implicated in regulation of inflammation and protection, i.e., nuclear factor-B activation, expression of adhesion molecules and chemokine receptors, production of proinflammatory cytokines and mediators, IL-10 synthesis, T cell proliferation and activity, inflammatory cell migration, expression of antioxidative enzymes, and apoptosis. The antiinflammatory effects of -MSH have been validated in animal models of experimentally induced fever; irritant and allergic contact dermatitis, vasculitis, and fibrosis; ocular, gastrointestinal, brain, and allergic airway inflammation; and arthritis, but also in models of organ injury. One obstacle limiting the use of alpha-MSH in inflammatory disorders is its pigmentary effect. Due to its preserved antiinflammatory effect but lack of pigmentary action, the C-terminal tripeptide of -MSH, KPV, has been delineated as an alternative for antiinflammatory therapy. KdPT, a derivative of KPV corresponding to amino acids 193–195 of IL-1, is also emerging as a tripeptide with antiinflammatory effects. The physicochemical properties and expected low costs of production render both agents suitable for the future treatment of immune-mediated inflammatory skin and bowel disease, fibrosis, allergic and inflammatory lung disease, ocular inflammation, and arthritis. Endocr Rev. 2008 Aug;29(5):581-602. doi: 10.1210/er.2007-0027. Epub 2008 Jul 8. Brzoska T1, Luger 34 TA, Maaser C, Abels C, Böhm M. KETAMINE

Purity: >99% (HPLC on request)

Molecular Formula: Ketamine treatments have become an increasingly popular solution for C H Cl NO 13 17 2 treatment- resistant depression, anxiety, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), Complex Regional Pain Syndrome (CRPS/ Molecular Weight: RSD), and other chronic pain conditions. Ketamine works by inhibiting 274.18 g/mol glutamate binding to NMDA-R receptors and has activity at norepinephrine, serotonin, and muscarinic cholinergic, kappa opioid, and voltage-sensitive Sequence: calcium channel receptors. A recommended starting dosage in ketamine naive Non-peptide patients is 0.5 mg/kg.

PROTOCOL: Content & Potency: 100mg, 150mg, 200mg troche Suggested dosage: Dissolve 1 troche under the tongue every night at bedtime

CLINICAL RESEARCH: Oral Ketamine for Depression: A Systematic Review. Oral ketamine is particularly appealing for its ease of use with the potential for high accessibility. Initial results suggest that oral ketamine has significant antidepressant effects with good overall tolerability. Both randomized controlled trials demonstrated antidepressant efficacy with good tolerability. Rapid antidepressant effects (ie, within 24 hours), antisuicide effects, and efficacy in treatment-resistant depression were reported only in retrospective studies. Dosages and frequency of administration were variable, with most studies providing dosages of 1-2 mg/kg every 1-3 days. No clinically significant adverse effects were reported. J Clin Psychiatry. 2019 Apr 16;80(3). pii: 18r12475. doi: 10.4088/JCP.18r12475.

35 MELANOTAN I

Purity: Melanotan I and Melanotan II are both analogs of the peptide hormone alpha- >98% (HPLC on request) melanocyte- stimulating hormone (α-MSH) that induces skin tanning. Like its predecessor, Melanotan I, MT 2 plays a role in stimulating melanogenesis and thus provides a protective mechanism against UV rays since under its actions melanocytes are able to increase production and secretion of the hormone melanin. Scientists have also noticed that MT 2 had a positive effect on libido due to its aphrodisiac properties. Additionally, MT 2 exhibits a mild positive fat-mobilizing effect. Melanotan I is an FDA approved drug under the brand name Scenesse. Scenesse is most commonly used to treat patients that have an intolerance to light.

PROTOCOL: Content & Potency: 2000mcg/ml subcutaneous injection provided in a 5ml vial. Suggested dosage: Inject 0.15ml once daily for 1 - 2 weeks then 0.25mL twice weekly thereafter for maintenance. For CIRS: Inject 100mcg every other day for 40 days.

CLINICAL RESEARCH: Evaluation of melanotan-II, a super potent cyclic melanotropic peptide in a pilot phase-I clinical study. A pilot phase I study was conducted with a cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (alpha-MSH). The lactam-bridged molecule, called Melanotan-II (MT-II), has the structure Ac-Nle4-Asp5-His6-D- Phe7-Arg8-Trp9-Lys10 alpha-MSH4-10-NH2 (MT-II) and has superpotent melanotropic activity in vitro. A single-blind, alternating day (saline or MT-II), placebo-controlled trial was conducted in 3 normal male volunteers at the starting dose of 0.01 mg/kg of MT-II. Subcutaneous injections of MT-II or saline were given daily (Monday- Friday) for 2 consecutive weeks. Two subjects were escalated by 0.005 mg/kg increments to 0.03 mg/kg and one to 0.025 mg/ kg. The 0.03 mg/kg dose produced Grade II somnolence and fatigue in one of two subjects (WHO standards). Mild nausea, not requiring antiemetic treatment, was reported at most MT-II dose levels. A stretching and yawning complex appeared to correlate with the onset of spontaneous, Penile erections which were intermittently experienced for 1-5 hours after MT-II dosing, depending on the MT-II dose. Two subjects had increased pigmentation in the face, upper body and buttock, as measured by quantitative reflectance and by visual perception 1 week after MT-II dosing ended. These results demonstrate that MT-II has tanning activity in humans given only 5 low dose every other day by subcutaneous injection. The recommended single MTII dose for future Phase I studies is 0.025 mg/kg/ day. T. Dorr, Robert & Lines, Ruskin & Levine, Norman & Brooks, Chris & Xiang, Li & Hruby, Victor & E. Hadley, Mac. (1996). Evaluation of Melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life sciences. 58. 1777-84.

36 METFORMIN + DHEA + SERMORELIN

Metformin has been used in a variety of health disease states to help control blood sugar, increase fertility in patients with PCOS, and aid in weight loss. It works to decrease hepatic glucose production, decrease intestinal absorption of glucose and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Current studies are lookin at metformin’s effect on improving physiologic responses to processes such as inflammation, oxidative damage, diminished autophagy, cell senescence and apoptosis. DHEA declines steadily as we age, and low levels of DHEA have been associated with Alzheimer’s disease, cancer, and atherosclerotic disease. DHEA offers you an exciting option to help increase natural testosterone production. Sermorelin is a synthetic hormone peptide composed of 29 amino acids. It’s similar in structure to a growth hormone releasing hormone (GHRH). It’s commonly utilized to optimize growth hormone levels in adults, while offering a variable IGF-1 increase. Sermorelin works to improve hormonal balance and enhance energy, burn fat, increase lean muscle, improve sleep quality, enhance memory, sex drive and more, by stimulating the production and release of hormones by the pituitary

PROTOCOL: Content & Potency: Metformin 250mg + DHEA 25mg + Sermorelin 250mcg capsule Suggested dosage: Take 2 capsules by mouth daily.

CLINICAL RESEARCH: Metformin: A Hopeful Promise in Aging Research. Over the past two decades, metformin has emerged as the first-line treatment for people with type 2 diabetes (T2DM) and is the most widely prescribed antidiabetic drug in the world (American Diabetes Association 2014). In addition to its use in T2DM, metformin is being prescribed for the treatment of polycystic ovary syndrome, diabetic nephropathy, and gestational diabetes, and has shown early promise as a treatment for cancer. Historically, despite its well-accepted antidiabetic properties in the 1950s, and use for hyperglycemia treatment in England in 1958, metformin remained contraindicated largely because of concerns about lactic acidosis and it was not approved by the U.S. Food and Drug Administration until 1994. We now know that the rare event of lactic acidosis occurs in >0.01 to 0.08 cases (average, 0.03) per 1000 patient-years caused by an insufficient metformin clearance by the kidneys. Therefore, the risk of side effects is relatively low in comparison to the multiple benefits of metformin. According to recent published data in different animal models, metformin appears to be a promising candidate as a life- extending drug. This compound is generally well tolerated and its long history of clinical use makes it an even more attractive candidate. Besides, metformin is more beneficial than any other anti-diabetic drug in reducing age-related diseases and improving survival in diabetic patients. Cold Spring Harb Perspect Med. 2016 Mar 1;6(3):a025932. doi: 10.1101/cshperspect.a025932.

37 NAD+

Purity: NAD+ is the second most popular cofactor in the human body. Anti-aging >99% therapies becoming more mainstream as aging is now more often being viewed as a disease. Now that this transition is happening, the ability for NAD+ to activate Molecular Formula: PARPS, Sirtuins, and help with immune dysregulation has been thoroughly investigated and NAD+ and its precursors have been highly popularized. C H N O P 21 28 7 14 2 The clinical importance of maintaining cellular NAD+ levels was established early Molecular Weight: in the last century with the finding that pellagra, a disease characterized by 663.43 g/mol diarrhea, dermatitis, dementia and death, could be cured with foods containing the NAD+ precursor niacin. Additionally, cellular concentrations of NAD+ have been Sequence: shown to decrease under conditions of increased oxidative damage such as occur Non-peptide during aging

Altered levels of NAD+ have been found to accompany several disorders associated with increased oxidative/free radical damage including diabetes, heart disease, age-related vascular dysfunction, ischemic brain injury, misfolded neuronal proteins, and Alzheimer’s dementia .

Interventions targeted at restoring NAD+ have been shown in animal models to support healthy aging and improve metabolic function, and dementia as well.

PROTOCOL: Content & Potency: 200mg/ml 10mL Suggested dosage: please inquire, dosing varies based on indication

CLINICAL RESEARCH: NAD+ and Sirtuins in Aging and Disease Nicotinamide adenine dinucleotide (NAD+) is a classical coenzyme mediating many redox reactions. NAD+ also plays an important role in the regulation of NAD+-consuming enzymes, including sirtuins, poly-ADP-ribose polymerases (PARPs), and CD38/157 ectoenzymes. NAD+ biosynthesis, particularly mediated by nicotinamide phosphoribosyltransferase (NAMPT), and SIRT1 function together to regulate metabolism and circadian rhythm. NAD+ levels decline during the aging process and may be an Achilles’ heel, causing defects in nuclear and mitochondrial functions and resulting in many age-associated pathologies. Restoring NAD+ by supplementing NAD+ intermediates can dramatically ameliorate these age-associated functional defects, counteracting many diseases of aging, including neurodegenerative diseases. Thus, the combination of sirtuin activation and NAD+ intermediate supplementation may be an effective anti-aging intervention, providing hope to aging societies worldwide. Shin-ichiro Imai1 and Leonard Guarente2,3

38 NANDROLONE

Purity: Nandrolone is a synthetic anabolic steroid that is best known for its immense >99% stimulatory effect on muscle growth. Structurally it is very similar to the better known Testosterone, but it has a much better myogenic:androgenic ratio.This is due Molecular Formula: to the fact that when nandrolone is broken down by 5 alpha-reductase (5AR) in androgenic tissues, its metabolite is substantially less active compared to the highly C H O 18 26 2 active dihydrotestosterone (DHT) metabolite of testosterone. The major benefit of this less active metabolite is a better side effect profile. It dramatically decreases Molecular Weight: the occurrence of alopecia as well as prostate growth, which are both common side 274.4 g/mol effects of Testosterone Replacement Therapy (TRT). In addition to muscle growth, nandrolone can have many positive effects on males suffering from hypogonadism. Sequence: Historically, this condition has caused problems with cardiovascular disease, Non-peptide diabetes, atherosclerosis, dyslipidemia and metabolic syndrome. Supplementation of nandrolone in men with hypogonadism will decrease risk factors for all of the conditions mentioned above, as well as increase muscle and lean body mass.

PROTOCOL: Content & Potency: 200mg/mL 5mL or 10mL injectable Suggested dosage: 0.5mL - 1mL into the muscle once weekly

CLINICAL RESEARCH: Beyond testosterone cypionate: evidence behind the use of nandrolone in male health and wellness Characterized by low serum testosterone levels and diverse symptoms, male hypogonadism is a common condition. Current medical treatment focuses on testosterone supplementation using multiple modalities such as injections, gels and pellets. Interestingly, while testosterone is considered an anabolic androgenic steroid, it has not been saddled with the social stigma that other, similar medications have. The goal of this review is to highlight an anabolic steroid, 19-nortestosterone (i.e., nandrolone, deca-durabolin) and illustrate prospective therapeutic applications for male health. Containing a chemical structure similar to testosterone, nandrolone has a higher myotrophic: androgenic ratio resulting in improved effects on muscle mass. Animal models have suggested application in the improvement of joint healing following rotator cuff repair. Minimal literature exists regarding the use of nandrolone and, as such, further human studies are required. Pan, Michael M, and Jason R Kovac. “Beyond testosterone cypionate: evidence behind the use of nandrolone in male health and wellness.” Translational andrology and urology vol. 5,2 (2016): 213-9. doi:10.21037/ tau.2016.03.03

39 OXYTOCIN

Purity: While Oxytocin certainly lives up to its reputation as the “Love Hormone,” it also has broader applications like weight management and a performance enhancer. Oxytocin levels reach >98% extreme levels during childbirth and breastfeeding, however they have also found to be elevated during sexual arousal, skin to skin contact, and orgasm. Due to this, research has Molecular Formula: been conducted and shown that exogenous administration of Oxytocin can improve libido, orgasm intensity/frequency and sexual pleasure. For weight management, oxytocin C43H66N12O12S2 administration has been shown to decrease overall weight through reduced caloric Molecular Weight: consumption in both animal and human models. Data suggests this is done by modulating the activation of hedonic food motivation pathways. The ventral tagmental area (VTA) is one part 1007.2 g/mol of this pathway and the origin of dopaminergic bodies. The VTA also has oxytocin receptors, and it is believed that saturating these receptors with exogenous oxytocin administration is Sequence: what leads to the downstream effect of decreased food desire. Lastly, a study has shown that Non-peptide oxytocin may provide benefit in team and personal performance. It showed a direct link between oxytocin, prosocial behavior and social emotions, all of which are key to team performance. Oxytocin can greatly increase one’s ability to trust, empathy, overall team cohesion, and more. While more research needs to be done on this topic, initial results seem very promising that all corporate and athletic teams could benefit from more Oxytocin.

PROTOCOL: Content & Potency: 20 - 100 IU sublingual troche or 20 IU nasal spray Suggested dosage: Varies depending on indication

CLINICAL RESEARCH: Effects of Intranasal Oxytocin on the Blood Oxygenation Level-Dependent Signal in Food Motivation and Cognitive Control Pathways in Overweight and Obese Men. Recent research indicates that the hypothalamic neuropeptide hormone oxytocin is a key central nervous system factor in the regulation of food intake and weight. However, the mechanisms underlying the anorexigenic effects of oxytocin in humans are unknown and critical to study to consider oxytocin as a neurohormonal weight loss treatment. We performed a randomized, double-blind, placebo-controlled crossover study with single-dose intranasal oxytocin (24 IU) in ten overweight or obese, otherwise healthy men. Following oxytocin/placebo administration, participants completed an established functional magnetic resonance imaging food motivation paradigm. We hypothesized that oxytocin would reduce the blood oxygenation level- dependent (BOLD) signal to high-calorie food vs non-food visual stimuli in the ventral tegmental area (VTA), the origin of the mesolimbic dopaminergic reward system. Following oxytocin administration,compared to placebo, participants showed bilateral VTA hypoactivation to high-calorie food stimuli. A secondary exploratory whole-brain analysis revealed hypoactivation in additional hedonic (orbitofrontal cortex, insula, globus pallidus, putamen, hippocampus, and amygdala) and homeostatic (hypothalamus) food motivation and hyperactivation in cognitive control (anterior cingulate and frontopolar cortex) brain regions following oxytocin administration vs placebo. Oxytocin administration reduces the BOLD signal in reward-related food motivation brain regions, providing a potential neurobiological mechanism for the anorexigenic oxytocin effects in humans. Furthermore, our data indicate that oxytocin administration reduces activation in homeostatic and increases activation in cognitive control brain regions critically involved in regulating food intake and resolving affective conflict, respectively. Future studies are required to link these changes in brain activation to oxytocin effects on food intake and weight. Plessow F, Marengi DA, Perry SK, Felicione JM, Franklin R, Holmes TM, Holsen, LM, Makris N, Deckersbach T, Lawson EA. Effects of Intranasal Oxytocin on the Blood Oxygenation Level-De- pendent Signal in Food Motivation and Cognitive Control Pathways in Overweight and Obese Men. Neuropsychopharmacology. 2018 Feb;43(3):638-645. doi: 10.1038/npp.2017.226. Epub 2017 Sep 20. PubMed PMID:28930284; PubMed Central PMCID: PMC5770767.

40 PENTOSAN POLYSULFATE

Purity: >98% (HPLC on request)

Molecular Formula: Pentosan polysulfate is a semi-synthetic polysulfated xylan used for the relief of (C H Na O S )n 5 6 2 10 2 Osteoarthritis. The mechanism of PPS action in osteoarthritis is multifactorial, with both stimulation of cartilage matrix synthesis and prevention of cartilage Molecular Weight: breakdown. There are also systemic effects on blood lipid and fibrinolysis that may 602.473 g/mol help clear the subchondral circulation. In one study, after a series of four to six intra- articular PPS injections into knees of human volunteers, there was a Sequence: significant increase in the size of the synovial fluid hyaluronan without causing any Non- peptide inflammation or bleeding into the joint cavity.

PROTOCOL: Content & Potency: 250mg/ml solution provided in a 10ml vial. Suggested dosage: Inject 2mg/kg subcutaneous injection twice weekly for 6 weeks.

CLINICAL RESEARCH: To evaluate the effectiveness of injectable Pentosan Polysulfate Sodium (iPPS) on pain compared with baseline (clinical and statistical significance) in the controlled clinical trial setting ie confirm Therapeutic Goods Association Special Access Scheme (TGA SAS) data In the total study population, iPPS achieved a safe, well tolerated, clinically meaningful, statistically significant result over placebo as demonstrated by higher number of subjects with >50% reduction in KOOS pain score from baseline. NRA strata 4-6 produced highly clinical and statistically significant results over placebo and is the target population in our Phase 3 clinical trials,

Paradigm Phase 2b OA/BMEL Clinical Trial, December 2018

41 PITOLISANT

Purity: >98%

Molecular Formula:

C17H26ClNO Pitolisant is a selective histamine 3 receptor antagonist that is used for wakefulness Molecular Weight: and to fight excessive daytime sleepiness (EDS). It is the first drug with this indication 295.8 g/mol that is not a controlled substance. It works by increasing the release of histamine, which promotes wakefulness in the brain. It is a once daily administration in the Sequence: morning with a maximum daily dose of 36mg per day. It is generally well tolerated Non-peptide with the only minor side effects (<5% of patients) being insomnia, nausea, and anxiety.

PROTOCOL: Content & Potency: Wakix® 4.45mg or 17.8mg tablet Suggested dosage: Week 1: Initiate with a dosage of 8.9 mg once daily Week 2: Increase dosage to 17.8 mg once daily Week 3: May increase to the maximum recommended dosage of 35.6 mg once daily. It may take up to 8 weeks for some patients to achieve a clinical response

CLINICAL RESEARCH: Pitolisant: A Review in Narcolepsy with or without Cataplexy Pitolisant, an orally available, first-in-class antagonist/inverse agonist of the histamine 3 receptor, is approved in the EU (as of March 2016) for the treatment of narcolepsy with or without cataplexy in adults and in the USA (as of August 2019) for the treatment of excessive daytime sleepiness (EDS) in adults with narcolepsy. Pitolisant was demonstrated to have minimal risk of abuse in preclinical and clinical studies, and is the only anti-narcoleptic drug not scheduled as a controlled substance in the USA. The totality of evidence from pivotal and supportive phase III trials suggests that pitolisant administered at up to the recommended maximum dose of 36 mg once daily reduces EDS and cataplexy in adults with narcolepsy relative to placebo. Noninferiority of pitolisant to modafinil in the management of EDS was not demonstrated. Pitolisant was generally well tolerated in clinical trials. Consistent with its mechanism of action, the most common treatment-emergent adverse events included headache, insomnia and anxiety. With minimal abuse potential and offering the convenience of oral, once-daily administration, pitolisant extends the range of approved treatment options available to adult patients with narcolepsy with or without cataplexy.

Lamb YN. Pitolisant: A Review in Narcolepsy with or without Cataplexy. CNS Drugs. 2020 Feb;34(2):207-218. doi: 10.1007/s40263-020-00703-x. Review. PubMed PMID: 31997137.

42 PHENTERMINE/TOPIRAMATE

Purity: Phentermine is a noradrenergic drug, which is theorized to affect food intake >99% (HPLC on request) primarily via the enhancement of norepinephrine release and possibly via the blockade of norepinephrine reuptake as well. Topiramate treatment among Molecular Formula: patients with seizure disorders and migraines exhibit weight loss with a reduction in visceral body fat. Topiramate acts via modification of excitatory voltage-activated Phentermine: C H N 10 15 sodium and calcium channels, antagonism AMPA/KA receptors, and enhancement Topiramate: C H NO S 12 21 8 of gamma-aminobutyric acid receptor-mediated inhibitory currents. Among these Molecular Weight: actions, decreased calorie intake appears to be a significant factor associated with topiramate-induced weight loss in humans. In one study, the proportions of patients Phentermine: 149.23 g/mol Topiramate: 339.36 g/mol achieving ≥ 5% weight loss were 17% with placebo, 45% with low-dose Phentermine/ Topiramate, and 67% with full-dose Phentermine/Topiramate. Weight loss associated Sequence: with Phentermine/Topiramate may aid in improving metabolic and glycemic Non-peptide parameters, blood pressure, and lipids. Weight loss efficacy of Phentermine/ Topiramate has been demonstrated to sustain for up to 2 years.

PROTOCOL: Content & Potency: 37.5mg/23mg Capsule, 37.5mg/50mg Capsule Suggested dosage: Take one capsule by mouth every day.

CLINICAL RESEARCH: Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP) A 56-week randomized controlled trial was conducted to evaluate safety and efficacy of a controlled-release combination of phentermine and topiramate (PHEN/TPM CR) for weight loss (WL) and metabolic improvements. Men and women with class II and III obesity (BMI ≥ 35 kg/m(2)) were randomized to placebo, PHEN/TPM CR 3.75/23 mg, or PHEN/TPM CR 15/92 mg, added to a reduced-energy diet. Primary end points were percent WL and proportions of patients achieving 5% WL. Secondary end points included waist circumference (WC), systolic and diastolic blood pressure (BP), fasting glucose, and lipid measures. In the primary analysis (randomized patients with at least one postbaseline weight measurement who took at least one dose of assigned drug or placebo), patients in the placebo, 3.75/23, and 15/92 groups lost 1.6%, 5.1%, and 10.9% of baseline body weight (BW), respectively, at 56 weeks (P < 0.0001). In categorical analysis, 17.3% of placebo patients, 44.9% of 3.75/23 patients, and 66.7% of 15/92 patients, lost at least 5% of baseline BW at 56 weeks (P < 0.0001). The 15/92 group had significantly greater changes relative to placebo for WC, systolic and diastolic BP, fasting glucose, triglycerides, total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL). The most common adverse events were paresthesia, dry mouth, constipation, dysgeusia, and insomnia. Dropout rate from the study was 47.1% for placebo patients, 39.0% for 3.75/23 patients, and 33.6% of 15/92 patients. PHEN/TPM CR demonstrated dose-dependent effects on weight and metabolic variables in the direction expected to be beneficial with no evidence of serious adverse events induced by treatment.

Allison DB, Gadde KM, Garvey WT, Peterson CA, Schwiers ML, Najarian T, Tam PY, Troupin B, Day WW.

43 PT-141

Purity: Bremelanotide(PT-141) was developed from the peptide hormone Melanotan II. >98% (HPLC on request) In initial testing, Melanotan II induced darkening of skin pigment, but additionally caused sexual arousal and spontaneous erections as unexpected side effects in Molecular Formula: nine out of the ten original male volunteer test subjects. Further testing in animals showed Bremelanotide to induce lordosis (a sexual mating behavior) and C H N O 50 68 14 10 subsequently tested for its effect in humans. Although, most of the research has been targeted to women with female sexual dysfunction an it is effective Molecular Weight: medication in treating sexual dysfunction in both men (erectile dysfunction or 1025.2 g/mol impotence) and women (sexual arousal disorder). Unlike Viagra and other related medications, it does not act upon the vascular system, but directly increases sexual Sequence: desire via the nervous system. It is estimated that 43% of women (30 million is the Ac-Nle-cyclo[Asp-His-D-Phe- US) suffer from sexual dysfunction and 30 million men suffer from ED, with Arg-Trp-Lys]-OH incidence increasing 2-3 fold between ages 40-70. Bremelanotide currently has no contraindications and is 80% effective in men who don’t respond to Viagra or Cialis. For women, it causes a 50% increase in sexually satisfying experiences. If FDA approved, it will have the trade name Ayleesi.

PROTOCOL: Content & Potency: 10mg/ml subcutaneous injection provided in a 2ml vial. Suggested dosage: Inject 0.2mL subcutaneously as needed, 30 minutes to 6 hours prior to sexual activity. The ini- tial dose will establish a time frame for response. Men should start at 0.1ml and titrate up to and not exceed 0.4ml. Women should start at 0.2ml dosing protocol.

Content & Potency: 2.5mg/0.1mL Nasal spray 3mL Suggested dosage: One to two sprays intranasally, 1-4 hours prior to sexual activity. The initial dose will establish a time frame for response.

CLINICAL RESEARCH: Melanocortins in the Treatment of Male and Female Sexual Dysfunction Melanocortinergic agents are currently being investigated for a possible therapeutic role in male and female sexual dysfunction. These investigations were sparked by findings that systemic administration of a synthetic analog of alpha-MSH, MT-II, causes penile erections in a variety of species, including humans. Several other melanocortinergic agents including HP-228, THIQ, and bremelanotide (PT 141) have since been shown to have erectogenic properties thought to be due to binding to melanocortin receptors in the central nervous system, particularly the hypothalamus. Bremelanotide, a nasally administered synthetic peptide, is the only melanocortinergic agent that has been clinically studied in both males and females. Data from Phase II clinical trials of bremelanotide support the use of melanocortin based therapy for erectile dysfunction. Studies using animal models have demonstrated that pre-copulatory behaviors in female rats analogous to sexual arousal are evoked, and preliminary clinical data also suggest a role in promoting sexual desire and arousal in women. Based on bremelanotide clinical experience, administration of a melanocortin agonist is well tolerated and not associated the hypotension observed with phosphodiesterase-5 inhibitors currently used to treat erectile dysfunction. This review discusses investigations of melanocortin agonists for the treatment of sexual dysfunction with emphasis on proposed sites and mechanisms of action in the central nervous system that appear to be involved in melanocortinergic modulation of sexual function.

Shadiack, Annette & D Sharma, Shubh & C Earle, Dennis & Spana, Carl & J Hallam, Trevor. (2007).

44 RAPAMYCIN

Purity: Rapamycin was initially discovered as an antifungal metabolite produced by Streptomyces hygroscopicus from a soil sample of Easter Island and has been found to possess >98% (HPLC on request) immunosuppressive and anti-proliferative properties in mammalian cells due to its ability to inhibit mTOR. Rapamycin is a potent inhibitor of antigen-induced proliferation of T cells, B Molecular Formula: cells, and antibody production. Interest in sirolimus as an immunosuppressive therapy in organ transplantation derives from its unique mechanism of action, its unique side-effect profile, and C51H79NO13 its ability to synergize with other immunosuppressive agents.Rapamycin’s immunosuppressive Molecular Weight: and anti-proliferative properties has led to its use in the prevention of organ transplant rejection. 914.2 g/ml mTOR has been implicated in many of the processes that are associated with aging, including Sequence: cellular senescence, immune responses, cell stem regulation, autophagy, mitochondrial Non-peptide small molecules function, and protein homeostasis (proteostasis). Furthermore, Rapamycin’s inhibition of mTOR has been shown to regulate cell senescence thus reducing age-related pathology and loss of function, and ultimately improving physiological function and extending longevity. The downstream events that follow the inactivation of TOR result in the blockage of cell-cycle progression at the juncture of G1 and S phase.

PROTOCOL: Content & Potency: Oral: 3mg capsules provided in a quantity of 30. Cream: 0.001% transdermal cream provided in a 30ml transdermal applicator.

Suggested Dosage: Oral: Take 1 capsule by mouth once daily. Cream: Apply 0.5-0.75mL (2-3 clicks) to inner forearms once daily, rub in until fully absorbed.

CLINICAL RESEARCH: Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism Rapamycin, an inhibitor of mTOR, inhibits cell senescence in vitro and increases longevity in several species. Nrf2 levels have been shown to decrease with aging and silencing Nrf2 gene induces premature senescence. Therefore, we explored whether Nrf2 is involved in the mechanism by which rapamycin delays cell senescence. In wild-type (WT) mouse fibroblasts, rapamycin increased the levels of Nrf2, and this correlates with the activation of autophagy and a reduction in the induction of cell senescence, as measured by SA-β-galactosidase (β-gal) staining, senescence-associated secretory phenotype (SASP), and p16 and p21 molecular markers. In Nrf2KO fibroblasts, however, rapamycin still decreased β‐gal staining and the SASP, but rapamycin did not activate the autophagy pathway or decrease p16 and p21 levels. These observations were further confirmed in vivo using Nrf2KO mice, where rapamycin treatment led to a decrease in β‐gal staining and pro‐inflammatory cytokines in serum and fat tissue; however, p16 levels were not significantly decreased in fat tissue. Consistent with literature demonstrating that the Stat3 pathway is linked to the production of SASP, we found that rapamycin decreased activation of the Stat3 pathway in cells or tissue samples from both WT and Nrf2KO mice. Our data thus suggest that cell senescence is a complex process that involves at least two arms, and rapamycin uses Nrf2 to regulate cell cycle arrest, but not the production of SASP. Wang, Rong et al.

45 SCREAM CREAM

Purity: This is a topical cream that when applied to the clitoris can have dramatic results. It >98% has been reported that only ~25% of women achieve orgasm from sexual intercourse, and even with clitoral stimulation that number only increases to 43%, but Scream Sequence: Cream can make all the difference. Women have reported substantially increased Non-peptide libido, intensity of orgasm, and also vaginal lubrication. The cream is made of multiple medications (l-Citrulline, Aminophylline, Ergoloid Mesylate, and Pentoxifylline), but the primary mechanism of action is substantial vasodilation to the area of application which increases sensitivity. Another positive is that the cream achieves very little systemic absorption, which enables patients to use it without worry of drug interactions or side effects.

PROTOCOL: Content & Potency: 5mL syringe Suggested Dosage: Apply up to 0.5mL to clitoris 30 minutes prior to sexual activity

CLINICAL RESEARCH: A Pilot Study of a Topical Intervention for Treatment of Female Sexual Dysfunction. Many investigators reported that pharmacological treatment of female sexual dysfunction (FSD) has been a promising field yet to be explored. The purpose of this pilot study was to investigate the efficacy and safety of a topical cream containing small concentrations of three vasodilators with different mechanisms of action in treating FSD.The results of the pilot trial suggest that topical cream containing small concentrations of three vasodilators may act synergistically, and was effective in improving arousal, orgasmic, and satisfaction disorder with a safer profile for premenopausal and postmenopausal women with FSD. Further studies are recommended to be conducted using a large number of nondepressive and depressive patients.

Gomaa AA, Abdel Aziz NM, Thabet RH, Fouly HA, Altellawy SH, Gomaa GA. A Pilot Study of a Topical Intervention for Treatment of Female Sexual Dysfunction. J Clin Psychopharmacol. 2018 Feb;38(1):60- 67. doi: 10.1097/JCP.0000000000000811. PubMed PMID: 29176500.

46 SERMORELIN

Purity: Sermorelin is a synthetic hormone peptide composed of 29 amino acids. >98% (HPLC on request) It’s similar in structure to a growth hormone releasing hormone (GHRH). Growth hormone is required for normal growth, bone development and Molecular Formula: regulatory effects on protein, carbohydrate and lipid metabolism. Human

C149H246N44O42S aging is accompanied by declining growth hormone (gh) and insulin-like growth factor-1 (IGF-1) levels. Sermorelin is commonly utilized to optimize Molecular Weight: growth hormone levels in adults, while offering a variable IGF-1 increase. 3357.9 g/mol Sermorelin also aids in promoting a healthy immune system, along with improved hormonal balance enhanced energy, to burn fat, increase lean Sequence: muscle, improve sleep quality, enhance memory, sex drive and more, by H-DL-Tyr-DL-Ala-DL-Asp-DL-Ala-DL-xiIle-DL- stimulating the production and release of hormones by the pituitary. Phe-DL-xiThr-DL-Asn-DL-Ser-DL-Tyr-DL-Arg-DL- Sermorelin is normally prescribed at night to maximize the body’s natural Lys-DL-Val-DL-Leu-Gly-DL-Gln-DL-Leu-DL-Ser- DL-Ala-DL-Arg-DL-Lys-DL-Leu-DL-Leu-DL-Gln- cycle of growth hormone and stimulate the pituitary gland during REM DL-Asp-DL-xiIle-DL-Met-DL-Ser-DL-Arg-NH2 sleep.

PROTOCOL: Injectable: 2000mcg/mL 7.5ml Suggested Dosing: 0.15mL once daily, 5 of 7 nights a week, at bedtime 90 minutes after last caloric intake

Troche: 500mcg Suggested Dosing: Once daily, at bedtime 90 minutes after last caloric intake

CLINICAL RESEARCH: Growth hormone-releasing hormone (GHRH)-induced effects on sleep EEG and nocturnal secretion of growth hormone, cortisol and ACTH in patients with major depression. Studies in normal human subjects and animals suggest that the neuropeptide growth hormone-releasing hormone (GHRH) is a common regulator of the sleep EEG and nocturnal hormone secretion. In healthy volunteers GHRH prompts an increase in the amount of slow wave sleep (SWS) and in growth hormone (GH) secretion and blunting of cortisol release. Inhibition of GHRH may contribute to sleep-endocrine aberrances during depression. We tested the effects of pulsatile application of 4 x 50 micrograms GHRH on the sleep EEG and simultaneously investigated nocturnal hormone secretion in 10 inpatients (four females, six males) with the acute episode of major depression. In contrast to the effects of placebo, GH secretion increased distinctly and rapid-eye-movement (REM) density decreased during the second half of night. No other significant changes in sleep-endocrine activity, including SWS, cortisol and ACTH secretion, could be observed. We assume that hypothalamic-pituitary-adrenocortical system activity and slow wave sleep are inert to the influence of GHRH during acute depression. Cortisol and ACTH remained unchanged even in a subsample of five younger (aged 19-28 years) patients. This observation is in contrast to our recent finding that cortisol secretion is blunted in young normal volunteers after GHRH. But on the other hand, GHRH is capable of stimulating GH and inducing a decrease in REM density in these subjects. Steiger A1, Guldner J, Colla-Müller M, Friess E, Sonntag A, Schier T.

TMC now offers Sermorelin and Arginine Weight Loss Packs! The ultimate one-two punch to jump start weight loss, improve mood and boost your immune system!

47 SERMORELIN/GLYCINE

Sermorelin is a synthetic hormone peptide composed of 29 amino acids. It’s similar in structure to a growth hormone releasing hormone (GHRH). It’s commonly utilized to optimize growth hormone levels in adults, while offering a variable IGF-1 increase. Sermorelin works to improve hormonal balance and enhance energy, burn fat, increase lean muscle, improve sleep quality, enhance memory, sex drive and more, by stimulating the production and release of hormones by the pituitary. Glycine is an amino acid that can also act as a neurotransmitter. It has been used to help treat BPH, insomnia, schizophrenia, and stroke. Research has shown that it can also help to stimulate the pituitary gland to secrete growth hormone without increasing prolactin levels.

PROTOCOL: Content & Potency: Sermorelin 2000mcg/Glycine 5mg/mL 4mL Suggested Dosage: 0.2mL subcutaneous injection, 5 of 7 nights a week. Taken 90 minutes after last caloric intake.

CLINICAL RESEARCH: Stimulatory effect of glycine on human growth hormone secretion. Glycine was administered orally to 19 nonobese normal subjects and 12 subjects with partial gastrectomy. In the normal subjects, a clear and significant increase of serum human growth hormone level was observed, whereas prolactin and blood sugar levels were not affected after the drug administration. The facts demonstrated that glycine is one of the stimulatory agents inducing the pituitary gland to secrete hGH. Metabolism. 1978 Feb;27(2):201-8.

48 STANOZOLOL

Purity: >99% (HPLC on request)

Molecular Formula: C H N O 21 32 2 Stanozolol is a synthetic steroid that is derived from testosterone and possesses Molecular Weight: both anabolic and androgenic properties. Stanozolol acts as an androgen receptor agonist, similar to testosterone. It has been used to treat aplastic anemia, hereditary 328.5 g/mol angioedema, vascular disorders and growth failures. It has also been shown to reduce sex hormone binding globulin (SHBG) by over 50%. A high SHBG level indicates less Sequence: free testosterone is available to your tissues than would be expected by a total Non-peptide testosterone value.

PROTOCOL: Capsules: 20mg troche, 50mg troche Suggested Dosing: Dissolve ¼ to ½ troche under the tongue daily

CLINICAL RESEARCH: Sex hormone-binding globulin response to the anabolic steroid stanozolol: evidence for its suitability as a biological androgen sensitivity test. Stanozolol was administered orally for 3 days (0.2 mg/kg/day) The decrease in serum SHBG after short term administration of stanozolol reflects androgen responsiveness and, thus, may be used to differentiate patients with androgen insensitivity syndromes from those with other causes of male pseudohermaphroditism.

J Clin Endocrinol Metab. 1989 Jun;68(6):1195-200.

49 THYMOSIN ALPHA-1

Purity: >98% (HPLC on request)

Molecular Formula: Thymosin α-1 is a major component of Thymosin Fraction 5 and is responsible for C H N O restoring and modulating immune function, particularly cell mediated immune 129 215 33 55 function. Recent studies showed that Thymosin Alpha-1 molecule increased major Molecular Weight: histocompatibility complex (MHC) class-1 and Toll-like receptor expression as well as cytokine production, suggesting its immunoregulatory role. It is an FDA approved 3108.28 g/mol medication under the trade name zadaxin after it received orphan drug approval status. It is widely used and studied in multiple types of cancer and viral illnesses. Sequence: Some physicians are using thymosin for chronic fatigue and Lyme disease as well as Ac-Ser-Asp-Ala-Ala-Val-Asp- autoimmune function as well. TA 1 is thought to modulate the immune system by Thr-Ser-Ser- Glu-Ile-Thr-Thr- augmenting T-cell function. TA1 may affect thymocytes by stimulating their Lys-Asp-Leu-Lys-GluLysLys- differentiation or by converting them to active T cells. TA1 is rapidly absorbed, Glu-Val-Val-Glu-Glu-Ala-Glu- Asn-OH achieving peak serum concentrations within two hours.

PROTOCOL: Content & Potency: 3000 mcg/mL subcutaneous injection provided in a 5ml vial. Suggested dosage: Inject 0.15mL subcutaneously once daily until vial is empty.

CLINICAL RESEARCH: Thymosin Alpha 1: Biological activities, applications and engineering production Thymosin alpha 1 (Tα1), a 28-amino acid peptide, was first described and characterized from calf thymuses in 1977. This peptide can enhance T-cell, dendritic cell (DC) and antibody responses, modulate cytokines and chemokines production and block steroid-induced apoptosis of thymocytes. Due to its pleiotropic biological activities, Tα1 has gained increasing interest in recent years and has been used for the treatment of various diseases in clinics. Accordingly, there is an increasing need for the production of this peptide. So far, Tα1 used in clinics is synthesized using solid phase peptide synthesis. Here, we summarize the genetic engineering methods to produce Tα1 using prokaryotic or eukaryotic expression systems. The effectiveness of these biological products in increasing the secretion of cytokines and in promoting lymphocyte proliferation were investigated in vitro studies. This opens the possibility for biotechnological production of Tα1 for the research and clinical applications. Li, Juan Jenny et al. “Thymosin alpha 1: Biological activities, applications and genetic engineering production.” Peptides 31 (2010): 2151-2158.

50 THYMOSIN BETA-4

Purity: >98% (HPLC on request)

Molecular Formula: Thymosin is a hormone secreted from the thymus. Its primary function is to

C212H350N56O78S stimulate the production of T cells, which are an important part of the immune system. Thymosin also assists in the development of B cells to plasma cells to Molecular Weight: produce antibodies. The predominant form of Thymosin, Thymosin Beta 4, is a 4963.506 g/mol member of a highly conserved family of actin monomer- sequestering proteins. In addition to its role as a major actin-sequestering molecule, Thymosin Beta 4 plays a Sequence: role in tissue repair. Tβ4 has been found to play an important role in protection, Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala- regeneration and remodeling of injured or damaged tissues. The gene for Tβ4 has also Glu- lle-Glu-Lys-Phe-Asp-Lys-Ser- been found to be one of the first to be upregulated after injuries. Thymosin Beta 4 is Lys-Leu-Lys-LysThr-Glu-Thr-Gin- currently being trialed as a potential therapy for HIV, AIDS, and Influenza. Thymosin Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys- Beta 4 is most often prescribed for acute injury, surgical repair and for senior athletes. Glu-Thy-lleGlu-Gin-Glu-Lys-Gin- Ala-Gly-Glu-Ser It has most recently been shown to help regrow hair in addition to PRP.

PROTOCOL: Content & Potency: 3000mcg/ml subcutaneous injection provided in a 5ml vial. Suggested dosage: Inject 0.25ml subcutaneously daily for 20 days.

CLINICAL RESEARCH: Differential expression of the human thymosin-beta 4 gene in lymphocytes, macrophages, and granulocytes. A cDNA clone encoding human thymosin-beta 4 was isolated from a cDNA library prepared from peripheral blood leukocytes of a patient with acute lymphocytic leukemia. This clone contained the entire coding sequence of 43 amino acid residues of thymosin-beta 4 and had an initiation codon and two termination codons. The amino acid and nucleotide sequences in the coding region were well conserved between rat and human. Nine of 132 nucleotides were different in the coding sequences (93% homology), but the deduced amino acid sequences were identical. No signal peptide was found in the deduced protein sequence. Human thymosin-beta 4 mRNA, approximately 830 nucleotides in length, was about 30 nucleotides larger than rat thymosin-beta 4 mRNA. Expression of the human thymosin-beta 4 gene in various primary myeloid and lymphoid malignant cells and in a few human hematopoietic cell lines was studied. Northern blot analyses of different neoplastic B lymphocytes revealed that steady state levels of thymosin-beta 4 mRNA varied as a function of differentiation stage. Thymosin-beta 4 mRNA levels were decreased in myeloma cells as are class II human leukocyte antigen, Fc receptor, and complement receptor, suggesting a relationship between thymosin-beta 4 and the immune response. Thymosin-beta 4 mRNA was more highly expressed in mature granulocytes than in immature blastic cells. Treatment of THP-1 cells, a human monocytic cell line, with recombinant human interferon- lambda reduced the levels of thymosin-beta 4 mRNA. Its level decreased after differentiation of THP-1 cells into Ia+ macrophages, but increased after differentiation of HL-60 cells into Ia- macrophages. The pattern of thymosin-beta 4 gene expression suggests that it may play a fundamental role in the host defense mechanism. H Gondo, J Kudo, J W White, C Barr, P Selvanayagam, G F Saunders The Journal of Immunology December 1, 1987, 139 (11) 3840-3848;

51 TRIMIX

Purity: Trimix is used for male sexual function. It is an intracavernosal three-drug injectable >98% (HPLC on request) prescribed medication used to treat erectile dysfunction (ED). TriMix is used to describe a mixture of Papaverine, Phentolamine and Alprostadil (PGE). Each of these Molecular Formula: drugs produce a vasodilating effect when injected into the penis. The injection is done using a very small needle, inserted into the proper area along the shaft of the penis, so HeN O 2 2 the drug mixture is delivered into the corpus cavernosum. The mixture of drugs causes the corpus cavernosum to relax, dilate and fill with blood, resulting in penile erection. Molecular Weight: Trimax can provide a longer and fuller erection that may be sustained through orgasm 64.015 g/mol allowing for an improved sexual experience.

Sequence: Trimix is most useful for men who cannot take oral medication or for those who have Non-peptide failed on PDE5 inhibitors such as Viagra or Cialis. Penile injections, such as Trimix, have a faster onset of action than most oral medications. An erection is achieved in less than 5 minutes from administration.

PROTOCOL: Content & Potency: Alprostadil/Papaverine/Phentolamine 60mcg/30mg/3mg/mL 3mL Dosage: Inject 0.02-0.04ml(max 0.08ml) into the base of the penis as needed for sexual activity Transdermal Gel: Alprostadil/Papaverine/Phentolamine 10mg/30mg/0.5mg 15mL topiclick applicator Dosage: 0.5ml- 1mL applied to the base of the penis 30 minutes prior to sexual activity

CLINICAL RESEARCH: Trimix Intracavernosal Injection Therapy in the Patients with Erectile Dysfunction Vasoactive pharmacotherapy is now being widely used as a practical and reliable method for the treatment of the patients with erectile dysfunction. But the individual vasoactive agent has limitations in its clinical success and potential for side effects. So, the synergistic effect and low drug volume of each vasoactive drug in polypharmacotherapy of erectile dysfunction have made it possible to reduce both systemic and local complications with excellent success rate. A total of 223 patients with erectile dysfunction underwent a trial of intracavernous self injection therapy with Trimix. The volume of drug used ranged between 0.04 and 0.6ml (average:0.19ml). After a mean followup of 7.6 months(3-15 months), 141 patients(63.2%) left in the home injection program and among them, 125 patients(88.6%) had very high satisfaction. The drop-out rate was 36.8%(82 of 223) with most of the cases during early home phase. The causes of drop-out were the fear of needle or injection, inadequate response to injection, loss of interest and complications. Priapism (six patients, 3.8%), pain (six patients, 3.8%) and granuloma on injection site(one patient, 0.6%) were noticeable complications, but coporal fibrosis and systemic side effects were not noticed. In conclusion, Trimix intracavernosal injection therapy is minimally invasive, simple, relatively safe and, most of all, very effective method for the treatment of the patients with erectile dysfunctions

Ahn TY, Chung TK, Park HK, Kim KS, Choo MS.

** New Transdermal Gel Formulation

52 VITAMIN D

Purity: >98% (HPLC on request)

Molecular Formula: C H N O S 212 350 56 78 Vitamin D is required for the regulation of the minerals calcium and phosphorus found Molecular Weight: in the body. It also plays an important role in maintaining proper bone structure. It is important in non-skeletal tissues, and its deficiency is closely associated with 4963.506 g/mol increased risk of cancers, infections, autoimmune diseases, cardiovascular diseases, and diabetes mellitus. Vitamin D is mainly produced in the skin when directly Sequence: exposed to sunlight, or obtained from the diet. Vitamin D receptors are expressed Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala- on immune cells (B cells, T cells and antigen presenting cells) and these immunologic Glu- lle-Glu-Lys-Phe-Asp-Lys-Ser- cells are all capable of synthesizing the active vitamin D metabolite. Vitamin D can Lys-Leu-Lys-LysThr-Glu-Thr-Gin- Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys- also modulate the innate and adaptive immune responses. Deficiency in vitamin D Glu-Thy-lleGlu-Gin-Glu-Lys-Gin- is associated with increased autoimmunity as well as an increased susceptibility to Ala-Gly-Glu-Ser infection.

PROTOCOL: Content & Potency: 50,000IU Injection 4ml Vial Suggested dosage: Inject 1ml (50,000IU) intramuscular once weekly for 6-8 weeks

CLINICAL RESEARCH: Vitamin D and the immune system It is now clear that vitamin D has important roles in addition to its classic effects on calcium and bone homeostasis. As the vitamin D receptor is expressed on immune cells (B cells, T cells and antigen presenting cells) and these immunologic cells are all are capable of synthesizing the active vitamin D metabolite, vitamin D has the capability of acting in an autocrine manner in a local immunologic milieu. Vitamin D can modulate the innate and adaptive immune responses. Deficiency in vitamin D is associated with increased autoimmunity as well as an increased susceptibility to infection. As immune cells in autoimmune diseases are responsive to the ameliorative effects of vitamin D, the beneficial effects of supplementing vitamin D deficient individuals with autoimmune disease may extend beyond the effects on bone and calcium homeostasis. Aranow, Cynthia. “Vitamin D and the immune system.” Journal of investigative medicine : the official publication of the American Federation for Clinical Research vol. 59,6 (2011): 881-6. doi:10.2310/JIM.0b013e31821b8755

53 WHITENING CREAM

Purity: Whitening cream aids in decreasing the formation of melanin in the skin. It is used to >99% (HPLC on request) lighten areas of darkened skin such as freckles, age spots, and melasma. It can reduce post-inflammatory hyperpigmentation. When applied topically, it acts as a skin Sequence: depigmentation agent by inhibiting melanin synthesis. It inhibits the conversion of Non- peptide L-3,4-dihydroxyphenylalanine (L-DOPA) to melanin by inhibiting tyrosinase due to its structural similarity to an analog of melanin precursors. Studies have found that whitening cream affects the melanocyte system. It causes reduced production of melanosomes, a significant change in the internal structure of melanosomes, an increase in the breakdown of melanosomes and the destruction of organelles found in the melanocytes, leading to depigmentation.

PROTOCOL: Content & Potency: Hydrocortisone 1%/Tretinoin 0.05%/Hydroquinone 8%/Kojic acid 4% 30mL Topi-Click Suggested dosage: Apply a thin film to the affected area once daily, at least 30 minutes before bedtime.

CLINICAL RESEARCH: A comprehensive review of the long-term and short-term treatment of melasma with a triple combination cream Melasma is a common disorder of hyperpigmentation and generally involves areas of the face and neck. Hyperpigmentation is especially prevalent in darker complected patients and is often difficult to treat. Hydroquinone, tretinoin, and topical corticosteroids are well established monotherapeutic agents for treating melasma and hyperpigmentation; however, a stable, once-daily formulation triple combination cream containing 0.05% tretinoin, 4.0% hydroquinone, and 0.01% fluocinolone acetonide (Tri-Luma) represents the only commercially available combination of all three agents. This product is approved by the US FDA for the treatment of facial melasma. A number of publications have described the safety and efficacy of triple combination cream in over 2000 patients with melasma, some of whom were treated for >12 months. In the initial 8-week study, 29% of patients experienced complete clearing of melasma by week 8, and 77% were clear or almost clear by week 8. Similarly, good results were seen in the two long-term studies, with the clear/mild rate ranging from 78% to 84% of patients at month 6 and from 81% to 94% of patients at month 12. Adverse events were almost always mild in severity and typically occurred only at the application site. The primary concern for most physicians using corticosteroid- containing products on the face is skin atrophy. However, only two cases of skin atrophy were reported across the three published studies. Overall, the results of these extensive studies indicate that triple combination cream is efficacious in treating melasma and exhibits a safe profile with low potential for adverse events. Torok HM. A comprehensive review of the long-term and short-term treatment of melasma with a triple combination cream. Am J Clin Dermatol. 2006;7(4):223-30. Review. PubMed PMID: 16901182.

54 IV THERAPY

55 IV Therapy Protocols

Myer’s Cocktail 30mL vial

Contents: Uses: BUD (Beyond Use Date): Magnesium Chloride 4mg/ml • Asthma 14 days Calcium Gluconate .8mg/ml • Migraines Research: Dexpanthenol 1mg/ml • Fibromyalgia http://www.altmedrev.com/archive/ Pyridoxine HCL .4mg/ml • Muscle Spasm publications/7/5/389.pdf Ascorbic Acid 8mg/ml • Allergic Rhinitis Hydroxocobalamin 4mcg/ml • Chronic Fatigue Syndrome B Complex100 1ml Benzyl Alcohol 2%

Suggested Protocol: Draw up cocktail in single syringe. Add 10-20ml of Sterile Water. Administer slowly over 5-15 minutes through 25g butterfly needle. When administering this treatment for the 1st time, it is best to give 0.5 to 1ml and then wait 30 seconds or so before proceeding with the rest.

Glutathione

Contents: Uses: Research: Glutathione 200mg/ml 10ml & • Antioxidant Glutathione Metabolism and Parkinson’s Disease 30ml • Detoxifying Agent https://www.ncbi.nlm.nih.gov/pmc/articles/ • Auto-Immune Diseases PMC3736736/ • Neuroinflammation • Parkinson’s

Suggested Protocol: Recommended to be given alone!

Drip: Infuse 3-4ml (600-800mg) in 20ml SW over 15-20 minutes 2-3 times per week (Osmolarity= ~265mOsm/L). Any dose higher than 2500mg can be administered in 50cc NS bag.

Push: Once established on glutathione, 1-2 grams is commonly pushed post IV treatment. This is typically done with 10cc syringe of NS or SW over 3-5 minutes. Osmolarity = 1.59mOsm/ml

56 Magnesium

Contents: Uses: Research: Magnesium Chloride 200mg/ml 30ml • Migraines The Role of Magnesium in Pain Magnesium Sulfate 500mg/ml 10ml & 30ml • Asthma https://www.ncbi.nlm.nih.gov/books/ • Muscle Spasm NBK507245/ • Depression

Suggested Protocol: • Dosing varies • Chloride commonly infused at 2-5ml in 250ml-500ml not to exceed 3ml per minute. • **Monitor Blood Pressure** • Osmolarity: - MgCl = 2.95mOsm/ml - MgS = 4.06mOsm/ml

Ascorbic Acid

Contents: Uses: Research: Ascorbic Acid 500mg/ml 50ml • Cancer Adjunct Vitamin C and Immune Function • Immune Boosting https://www.ncbi.nlm.nih.gov/pmc/arti- • General Health cles/PMC5707683/ • Macular Degeneration

Suggested Protocol: • Dosing can vary significantly** • Drip: Infuse 25g over about 60 minutes in 500cc SW. • Recommend eating 1-3 hours prior to infusion to prevent hypoglycemia • After infusion, blood sugar will read falsely high, but do NOT administer insulin within 6-8 hours of infusion. • Osmolarity: 5.8mOsm/ml

BCAA (ISO-Leucine, Leucine, Valine)

Contents: Uses: Research: ISO-Leucine 5mg/Leucine • Weight Loss https://medcraveonline.com/JNHFE/JN- 10mg/Valine 5mg/ml HFE-09-00337.pdf • Improved Athletic Performance • Muscle Gain

Suggested Protocol: Infuse 10-30ml per infusion and can be added to bag with other additives such as L-Carnitine or B-Complex.

57 Edetate Disodium

Contents: Uses: Research:

Edetate Disodium 150mg/ml 30ml • Metal Chelation Rationale for the Successful Management of EDTA Chelation Therapy in Human Burden by Toxic Edetate Calcium Disodium 150mg/ml 30ml Metals https://www.ncbi.nlm.nih.gov/pmc/articles/ PMC5118545/

Suggested Protocol: • Edetate Disodium (NO CALCIUM) must be run at 1000-1500mg / 60 min OR SLOWER • Edetate Calcium Disodium can be run at 1000 mg / 30 minutes OR SLOWER. • Administer at rates recommended above BUT on the first administration run 50 –75% SLOWER. • Maximum regardless of weight is 3000 mg • Typically administered 1-2x per week • Can give EDTA twice a week but must have 48hr separation • Above CrCl of 2.2 DON’T do it • EDTA ½ life is only 1 hour BUT continues to have effect up to 3 weeks • NaEDTA Osmolarity = 1.34mOsm

Alpha Lipoic Acid

Contents: Uses: Research: Alpha Lipoic Acid 25mg/ml 30ml • Anti-oxidant Insights on the Use of α-Lipoic Acid for Therapeutic Purposes • Improves metabolism • Prevents and reverses https://www.ncbi.nlm.nih.gov/pmc/articles/ tissue damage PMC6723188/ • Neuropathy

Suggested Protocol: • Must administer ALONE. Mixing with other ingredients may result in degradation. • Commonly done as IV push at 4ml (100mg) in 5-10ml NS over 10-15min. • May increase by 1cc each visit up to 24ml maximum (600mg) • Osmolarity: 0.33mOsm/ml ALA is a potent anti-oxidant compound. It works with mitochondria and the body’s natural anti-oxidant defenses. ALA is also seen as an anti-aging compound since it can reverse some of the oxidant damage related to the effects of aging.

58 L-Carnitine

Contents: Uses: Research: Levocarnitine 500mg/ml 30ml • Weight Loss l-Carnitine Supplementation in Recovery after Exercise • Mental Health https://www.ncbi.nlm.nih.gov/pmc/articles/ • Performance and recovery PMC5872767/

Suggested Protocol: • Doses vary but commonly range from 500mg-2500mg IV 1-2x per in NS • Osmolarity: 4.71 mOsm/ml Carnitine plays a critical role in energy production. It transports long-chain fatty acids into the mitochondria so they can be oxidized (“burned”) to produce energy. Carnitine is concentrated in tissues like skeletal and cardiac muscle that utilize fatty acids as a dietary fuel. Carnitine may also be involved in the aging process because its concentration in tissues declines with age and thereby reduces the integrity of the mitochondrial membrane

N-Acetyl Cysteine

Contents: Uses: Research: N-Acetyl Cysteine 100mg/ • Anti-oxidant A Review on Various Uses of N-Acetyl Cysteine ml 10ml & 30ml • Detox https://www.ncbi.nlm.nih.gov/pmc/articles/ • Increase Glutathione PMC5241507/

Suggested Protocol: Infuse 3-5ml per infusion and can be done 2-3x per week. Commonly combined with other products such as ascorbic acid or b-complex.

MIC B12 + Carnitine

Contents: Uses: MIC B12 + Carnitine 10mg/40mg/40mg/1mg + 100mg 10ml &30ml • Energy MIC B12 25mg/25mg/50mg/1mg 10ml & 30ml • Weight loss

Suggested Protocol: Infuse 2-3ml IV once weekly

59 Vitamin B Complex 30mL vial

Contents: Uses: Research: Thiamine HCl 100mg/ml • General Health B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review Panthenol 100mg/ml • Energy Pyridoxine HCl 100mg/ml • Healthy Skin and Hair https://www.ncbi.nlm.nih.gov/pmc/arti- cles/PMC4772032/ Niacinamide 100mg/ml Riboflavin 20mg/ml

Suggested Protocol: • Infuse 1-3ml per infusion 2-3x per week(Osmolarity - 320mOsm/L in 500mL NS) • Commonly used as foundation for many IV treatment protocols • Osmolarity: 2.14mOsm/ml

Methylene Blue

Contents: Research: Uses: Methylene Blue 100mg/ml Methylene Blue Blocks and Reverses • Alzheimer’s the Inhibitory Effect of Tau on PMCA • Cancer 10ml & 30ml Function • Anti-bacterial • SIRT 1 Activator https://www.ncbi.nlm.nih.gov/pmc/ Methylene Blue has been shown to attenuate the articles/PMC6678728/ formations of amyloid plaques and neurofibrillary tangles, and to partially repair impairments in Suggested Protocol: mitochondrial function and cellular metabolism. Infuse 100mg over 20-30 minutes The ability of MB to activate SIRT1 promotes mitochondrial biogenesis and oxygen consumption and activates AMPK.

Phosphatidylcholine

Contents: Uses: Phosphatidylcholine 150mg/ml • Memory Loss 10ml & 30 ml • Cardiovascular Disease • Cirrhosis Suggested Protocol: • Weight Loss Every cell in our body is encapsulated by a membrane composed of a Typically, a two-hour infusion of double layer of phospholipids and the most abundant phospholipid is 875 mg – 1750 of Phosphatidyl- Phosphatidylcholine (PC). Phosphatidylcholine is the pivotal phospholipid that is prevalent in healthy young cell membranes and as we get older and/ choline is given 1 – 3x per week. or ill this phospholipid gets replaced with less beneficial phospholipids and At least 10 treatments of PC are this lipid layer can trap and store many toxins. Phosphatidylcholine is also a good source of choline, which is the main recommended. substrate for the production of the memory enhancing neurotransmitter, acetylcholine. Phosphatidylcholine is also an excellent fat emulsifier and thus is helpful to improve serum lipid profiles.

60 Implementing IV Therapy in Your Practice The fastest and most effective way to nourish your body back to health. IV Therapy is a method of feeding vitamins, minerals, and other natural substances directly into a patient’s bloodstream.

• Create an easy new revenue stream • Differentiate your practice by providing high quality IV infusions and bring in new patients • We can help educate you and your staff on the newest and most innovative IV Therapy protocols

IV Therapy Benefits: • Immune Support • Weight Loss • Hydration Help in a Variety of • Performance & Recovery Conditions: • Energy • Alzheimer’s/Parkinson’s • Anti-Aging • Cancer • Detox • Aging • Chelation • Chronic Inflammation • Migraines • Cardiovascular Disease • Chronic Fatigue • Metal Toxicity

61 We do all the work for you! We provide you with IV Infusion Kits with everything you will need to get started. These kits include:

• Normal Saline IV Bag • Tourniquet • IV Catheter • PVP Prep Pad • Syringe for mixing • Alcohol Swabs • 18g Needles • Sponge Gauze • Pair of Gloves • Transparent Dressing • Roll of Tape • IV Administration Set • Multi-Dose Vials needed for the infusions

Ask Us About Our IV Therapy Protocols!

Immune Boost: • Ascorbic Acid • Vitamin B-Complex • Osmolarity in 1000ml SW = ~284mOsm/L • Osmolarity in 1000ml NS = ~579mOsm/L • Can also add 1ml vial of Thymosin Alpha-1 to maximize results! Weight Loss: • MIC + B12 • L-Carnitine • BCAA (ISO-Leucine, Leucine, Valine) Performance and Recovery: • Amino Acids • B-Complex • Ascorbic Acid • Glutathione • Osmolarity in 1000ml SW = ~302mOsm/L • Osmolarity in 1000ml NS = ~591mOsm/L Anti-Aging: • Methylene Blue • Glutathione • Temsirolimus Cognitive Enhancement: • Methylene Blue • Glutathione • L-Carnitine

62 PRICE LISTS

63 Capsules & Tablets CAPSULES & TABLETS

PRODUCT POTENCY DOCTOR PRICE

2-Methoxyestradiol 200mg $12.00

Amlexanox 40mg $0.43

Ammonium Tetra-Thiomolybdate 30mg $0.75

Ammonium Tetra-Thiomolybdate 40mg $0.75

Amoxicillin 500mg $0.20

Anastrozole 0.25mg $0.66

Anastrozole 0.5mg $0.75

Anastrozole (Clear Dye Free Capsule) 0.5mg $0.75

Anastrozole 0.75mg $0.75

Anastrozole 1mg $0.53

Armour Thyroid 15mg $0.90

Armour Thyroid 30mg $0.90

Armour Thyroid 60mg $1.00

Armour Thyroid 90mg $1.20

Armour Thyroid 120mg $1.60

Armour Thyroid 180mg $1.60

Atrovastin Calcium 10mg $0.10

B Complex - $0.33

Biotin 5000mcg $0.40

Bupropion/Naltrexone/MIC/B12/ 500mcg $1.40 Carnitine

Bupropion/Naltrexone/MIC/B12/ 1000mcg $1.70 Carnitine

Cabergoline 0.5mg $6.00

Clomiphene Citrate 50mg $1.37

Danazol 25mg $1.00

Danazol 50mg $1.00

Deoxy-DHEA 25mg $1.50

Deoxy-DHEA 100mg $1.60

DHEA 5mg $0.37

DHEA 7mg $0.53 64 DHEA 10mg $0.47

DHEA 15mg $0.37

DHEA 25mg $0.53

DHEA 40mg $0.60

DHEA 50mg $0.63

DHEA 75mg $0.67

DHEA 100mg $0.70

DHEA/Pregnenolone 5/5mg $0.53

DHEA/Pregnenolone 5/10mg $0.53

DHEA/Pregnenolone 5/30mg $0.53

DHEA/Pregnenolone 5/50mg $0.65

DHEA/Pregnenolone 5/100mg $0.65

DHEA/Pregnenolone 20/10mg $0.53

DHEA/Pregnenolone 25/25mg $0.53

DHEA/Pregnenolone 25/50mg $0.53

DHEA/Pregnenolone 50/40mg $0.53

DHEA/Pregnenolone 50/50mg $0.80

DHEA/Pregnenolone 100/100mg $0.80

DIM 150mg $0.50

Doxycycline Hyclate 100mg $0.50

Dutasteride 0.5mg $1.00

Enclomiphene 5mg $0.97

Enclomiphene 12.5mg $0.97

Enclomiphene 25mg $1.25

Enclomiphene (Veggie/Dye Free Capsule) 25mg $1.25

Escitalopram 10mg $0.50

Estradiol 0.5mg $0.25

Estradiol 1mg $0.17

Estradiol 2mg $1.00

Estradiol 3mg $1.00

Estriol/Estradiol 80/20 5mg $1.10

Exemestane 10mg $0.60

Exemestane 20mg $0.80

65 Exemestane 25mg $3.50

Finasteride 1mg $0.92

Finasteride 5mg $1.00

Glipizide 5mg $0.12

Hydrochlorothiazide 25mg $0.20

Hydrocortisone 5mg $0.83

Hydrocortisone 10mg $0.83

Hydrocortisone 20mg $1.17

KPV (Enteric Coated) 500mg $2.16

Letrozole 2.5mg $0.50

Levofloxacin 750mg $2.00

Levothyroxine 25mcg $0.80

Levothyroxine 75mcg $0.80

Levothyroxine 125mcg $1.60

Levothyroxine Sodium 50mcg $0.80

Levothyroxine(T4) E4M 137mg $0.75

Levothyroxine(T4) E4M (Veggie Capsule) 93mg $0.75

Liothyronine(T3) E4M 1.5mcg $0.20

Liothyronine(T3) E4M 10mcg $0.75

Liothyronine/Levothyroxine 4.5/19mcg $0.80

Liothyronine 5mcg $0.80

Liothyronine 15mcg $0.80

Liothyronine 25mcg $1.93

Liothyronine 30mcg $0.80

Liothyronine 50mcg $1.93

Lisinopril 10mg $0.06

Losartan 50mg $0.25

Magnesium Oxide 400mg $0.25

Metformin 500mg $0.40

Metformin 1000mg $0.50

Metformin XR 500mg $0.40

Metformin XR 750mg $0.50

Metoprolol Succinate 25mg $0.25

66 DMHeEtrAo prolol Tartrate 2150mg $0.2407

Modanafil 100mg $1.00 DHEA 15mg $0.37 Modanafil 200mg $1.25 DHEA 25mg $0.53 Nabumetone 750mg $1.25 DHEA 40mg $0.60 Naltrexone 0.5mg $0.50 DHEA 50mg $0.63 Naltrexone 1mg $0.60 DHEA 75mg $0.67 Naltrexone 1.5mg $0.70 DHEA 100mg $0.70 Naltrexone 2mg $0.75 DHEA/Pregnenolone 5/5mg $0.53 Naltrexone 2.25mg $0.80 DHEA/Pregnenolone 5/10mg $0.53 Naltrexone 2.5mg $0.90 DHEA/Pregnenolone 5/30mg $0.53 Naltrexone 3mg $0.90 DHEA/Pregnenolone 5/50mg $0.65 Naltrexone 3.5mg $1.00 DHEA/Pregnenolone 5/100mg $0.65 Naltrexone 4.5mg $1.10 DHEA/Pregnenolone 20/10mg $0.53 Naltrexone 5mg $1.20 DHEA/Pregnenolone 25/25mg $0.53 Nature Throid 15mg $0.50 DHEA/Pregnenolone 25/50mg $0.53 Nature Throid 32.5mg $0.38 DHEA/Pregnenolone 50/40mg $0.53 Nature Throid 48mg $0.60 DHEA/Pregnenolone 50/50mg $0.80 Nature Throid 65mg $0.50 DHEA/Pregnenolone 100/100mg $0.80 Nature Throid 97.5mg $0.60 DIM 150mg $0.50 Nicotinamide Mononucleotide 250mg $1.50 Doxycycline Hyclate 100mg $0.50 Nicotinamide Mononucleotide 400mg $2.25 Dutasteride 0.5mg $1.00 NP Thyroid 15mg $0.75 Enclomiphene 5mg $0.97 NP Thyroid 30mg $0.75 Enclomiphene 12.5mg $0.97 NP Thyroid 60mg $0.75 Enclomiphene 25mg $1.25 NP Thyroid 90mg $1.00 Enclomiphene (Veggie/Dye Free Capsule) 25mg $1.25 Oxandrolone 5mg $3.00 Escitalopram 10mg $0.50 Oxandrolone 10mg $3.20 Estradiol 0.5mg $0.25 Oxandrolone 15mg $3.20 Estradiol 1mg $0.17 Oxandrolone 20mg $3.00 Estradiol 2mg $1.00 Oxandrolone 25mg $3.20 Estradiol 3mg $1.00 Phenibut HCL 300mg $0.50 Estriol/Estradiol 80/20 5mg $1.10 Phentermine 15mg $0.47 Exemestane 10mg $0.60 Phentermine HCL 30mg $0.80 Exemestane 20mg $0.80

67 Phentermine HCL 37.5mg $1.00

Phentermine HCL SR 20mg $0.85

Phentermine HCL SR 37.5mg $0.90

Phentermine SR 45mg $1.10

Phentermine/Topiramate 37.5/23mg $1.23

Phentermine/Topiramate 37.5/50mg $1.23

Pravastin 10mg $0.33

Pregnenolone 5mg $1.20

Pregnenolone 25mg $0.43

Pregnenolone 40mg $1.20

Pregnenolone 50mg $1.20

Pregnenolone 100mg $1.20

Pregnenolone/DHEA 100/25mg $1.57

Progesterone 5mg $0.77

Progesterone 35mg $0.77

Progesterone 75mg $0.70

Progesterone 175mg $1.10

Progesterone 225mg $1.30

Progesterone IR 200mg $1.25

Progesterone IR 250mg $1.50

Progesterone SR 25mg $0.50

Progesterone SR 37.5mg $0.60

Progesterone SR 50mg $0.60

Progesterone SR 80mg $0.80

Progesterone SR 100mg $0.80

Progesterone SR 125mg $0.90

Progesterone SR 150mg $1.00

Progesterone SR (Clear Dye Free Capsule) 150mg $1.00

Progesterone SR 175mg $1.10

Progesterone SR 200mg $1.20

Progesterone SR 250mg $1.50

Propranolol 20mg $0.50

Sildenafil 20mg $2.00

68 DSiHldEeAn afil 1205mg $02.4275

Sildenafil 50mg $4.00 DHEA 15mg $0.37 Sildenafil 60mg $4.00 DHEA 25mg $0.53 Sildenafil 100mg $3.50 DHEA 40mg $0.60 Sildenafil 110mg $3.67 DHEA 50mg $0.63 Sildenafil 150mg $4.00 DHEA 75mg $0.67 Sirolimus 1mg $9.00 DHEA 100mg $0.70 Sirolimus 2mg $15.00 DHEA/Pregnenolone 5/5mg $0.53 Spironolactone 25mg $0.25 DHEA/Pregnenolone 5/10mg $0.53 Spironolactone 50mg $0.33 DHEA/Pregnenolone 5/30mg $0.53 Spironolactone 100mg $0.50 DHEA/Pregnenolone 5/50mg $0.65 Synthroid 125mcg $1.50 DHEA/Pregnenolone 5/100mg $0.65 Tadalafil 2.5mg $1.00 DHEA/Pregnenolone 20/10mg $0.53 Tadalafil 5mg $1.25 DHEA/Pregnenolone 25/25mg $0.53 Tadalafil 10mg $1.50 DHEA/Pregnenolone 25/50mg $0.53 Tadalafil 15mg $1.50 DHEA/Pregnenolone 50/40mg $0.53 Tadalafil 20mg $4.33 DHEA/Pregnenolone 50/50mg $0.80 Tadalafil 25mg $2.00 DHEA/Pregnenolone 100/100mg $0.80 Tadalafil 40mg $2.25 DIM 150mg $0.50 Tadalafil 50mg $2.50 Doxycycline Hyclate 100mg $0.50 Tamoxifen 10mg $0.75 Dutasteride 0.5mg $1.00 Tamoxifen 20mg $1.00 Enclomiphene 5mg $0.97 Triamterene and Hydrochlorothiazide 37.5/25mg $0.25 Enclomiphene 12.5mg $0.97 Valacyclovir 500mg $0.50 Enclomiphene 25mg $1.25 Valacyclovir 1g $0.75 Enclomiphene (Veggie/Dye Free Capsule) 25mg $1.25 Vitamin D 25,000iu $0.50 Escitalopram 10mg $0.50 Vitamin D2 50,000iu $2.50 Estradiol 0.5mg $0.25 Vitamin D3 5000IU $0.50 Estradiol 1mg $0.17 Zolpidem Tartrate 10mg $1.00 Estradiol 2mg $1.00 Estradiol 3mg $1.00

Estriol/Estradiol 80/20 5mg $1.10

Exemestane 10mg $0.60 Exemestane 20mg $0.80

69 INJInjectionsECTIONS

Alpha Lipoic Acid 25mg/mL 30mL $55.00

Alprostadil/Papaverine 60mcg/30mg/ 3mL $50.00 Phentolamine 3mg/mL

Ascorbic Acid (Commercial) 500mg/mL 50mL $130.00

Ascorbic Acid 500mg/mL 50mL $49.00

BCAA’s (Leucine, ISO-Leucine, Valine) 20mg/10mg/10mg/ml 30ml $28

Biotin 5mg/mL 1mL $12.00

Biotin 5mg/mL 2mL $20.00

Biotin 5mg/mL 5mL $20.00

Calcium Chloride 100mg/mL 10mL $25.00

Calcium Chloride 100mg/mL 30mL $25.00

Calcium Gluconate 100mg/mL 50mL $24.00

DEPO - Testosterone Cypionate 200mg/mL 10mL $140.00

Dexpanthenol 250mg/mL 30mL $18.00

Edetate Calcium Disodium 150mg/mL 30mL $40.00

Edetate Disodium 150mg/mL 10mL $25.00

Estradiol Cypionate 10mg/mL 1mL $13.00

Estradiol Cypionate 10mg/mL 2mL $26.00

Estradiol Cypionate 10mg/mL 5mL $65.00

Folic Acid 5mg/mL 30mL $25.00

GAC 25mcg/100mcg/ 10mL $15.00 250mcg/mL

GAC 25mcg/100mcg/ 30mL $27.00 250mcg/mL

Genotropin - 0.8mg Syringe (#7) $800.00

Glutathione 200mg/mL 10mL $20.00

Glutathione 200mg/mL 30mL $40.00

GOAL 25/75/150/150mg/mL 30mL $44.00

Hydroxocobalamin 25mg/mL 10mL $30.00

L-Carnitine 500mg/mL 30mL $43.00

Lysine 200mg/mL 30mL $50.00 70 Magnesium Chloride 200mg/mL 50mL $30.00

Magnesium Sulfate 500mg/mL 10mL $30.00

Methylcobalamin 1mg/mL 10mL $18.00

Methylcobalamin 10mg/mL 10mL $29.00

Methylcobalamin 10mg/mL 30mL $40.00

Methylene Blue 100mg/ml 10ml $18.00

Methylene Blue 100mg/ml 30ml $32.00

MIC B12 + Carnitine 40/40/1/100 30mL $34.00

Myers Cocktail 4/0.8/1/0.4/8/0.0041 30mL $55.00 mg/mL

NAD+ 200mg/ml 10mL $95.00

Nandrolone Decanoate 200mg/mL 5mL $45.00

Nandrolone Decanoate 200mg/mL 10mL $88.80

Nicotinamide Mononucleotide 200mg/ml 10mL $140.00

Norditropin Nordiflex Pen - 5mg $700.00

Norditropin Nordiflex Pen - 10mg $1,300.00

Norditropin Nordiflex Pen - 15mg $2,020.00

Novarel - 5000 IU lyophilized $200.00 vial with 10mL bacteriostatic water

Omnitrope - 5.8mg $360.00

Pentosan Polysulfate Sodium 250 mg/mL 5mL $70.00

Pregnyl 10,000IU 10mL $120.00

Procaine HCL 20mg/mL 5mL $10.00

Pyridoxine 100mg/mL 10mL $25.00

Pyridoxine 100mg/mL 30mL $60.00

Saizen - 5mg $789.00

Taurolidine 2% 250mL $100.00

Testosterone Cypionate (GSO) 100 mg/mL 1mL $13.00

Testosterone Cypionate (GSO) 100 mg/mL 2mL $17.00

71 Testosterone Cypionate (GSO) 100 mg/mL 5mL $40.00 Testosterone Propionate 100mg/mL 4mL $18.00 Testosterone Cypionate (GSO) 200mg/mL 7mL $22.00 Testosterone Propionate 100mg/mL 5mL $22.00 Testosterone Cypionate (GSO) 200mg/mL 10mL $26.00 Testosterone Propionate 100mg/mL 8mL $30.00 Testosterone Cypionate (GSO) 200mg/mL 1mL $12.00 Testosterone Propionate 100mg/mL 10mL $35.00 Testosterone Cypionate (GSO) 200mg/mL 2mL $12.00 Thiamine HCL 100mg/mL 30mL $30.00 Testosterone Cypionate (GSO) 200mg/mL 3mL $15.00 Vitamin B-Complex - 30mL $45.00 Testosterone Cypionate (GSO) 200mg/mL 4mL $16.00 Zomacton (lyophilized) - 5mg $348.00 Testosterone Cypionate (GSO) 200mg/mL 5mL $20.00 PT 141 10000mcg/mL 2mL $115.00 Testosterone Cypionate (GSO) 200mg/mL 6mL $21.00 Sermorelin 2000mcg/mL 7.5mL $85.00 Testosterone Cypionate (GSO) 200mg/mL 8mL $23.00 Sermorelin/Glycine 2000mcg/5mg/mL 4mL $85.00 Testosterone Cypionate (GSO) 200mg/mL 10mL $26.00 Thymosin Alpha 3000mcg/mL 5mL $150.00 Testosterone Cypionate (Commercial) 200mg/mL 10mL $60.00 Thymosin Alpha PF 3000mcg/mL 0.2mL $7.50 Testosterone Cypionate 200mg/mL 2mL $17.00 Thymosin Beta 3000mcg/mL 5mL $150.00 Testosterone Cypionate/Anastrozole 200/0.5mg/mL 10mL $35.00 Thymosin Beta PF 3000mcg/mL 0.25mL $7.50

Testosterone Cypionate/Enanthate 100/100mg/mL 2mL $16.00

Testosterone Cypionate/Enanthate 100/100mg/mL 6mL $25.00

Testosterone Cypionate/Enanthate 100/100mg/mL 10mL $40.00

Testosterone Cypionate 80/80/40mg 4mL $20.00 /Enanthate/Propionate

Testosterone Cypionate 80/80/40mg 10mL $40.00 /Enanthate/Propionate

Testosterone Cypionate/Propionate 180/20mg/mL 1mL $10.00

Testosterone Cypionate/Propionate 180/20mg/mL 4mL $22.00

Testosterone Cypionate/Propionate 180/20mg/mL 5mL $25.00

Testosterone Cypionate/Propionate 180/20mg/mL 6mL $27.00

Testosterone Cypionate/Propionate 180/20mg/mL 10mL $35.00

Testosterone Enanthate (GSO) 100mg/mL 2mL $44.00

Testosterone Enanthate (GSO) 200mg/mL 10mL $44.00

Testosterone Enanthate 200mg/mL 4mL $22.00

Testosterone Enanthate 200mg/mL 5mL $27.00

Testosterone Enanthate 200mg/mL 6mL $30.00

72 Testosterone Propionate 100mg/mL 4mL $18.00

Testosterone Propionate 100mg/mL 5mL $22.00

Testosterone Propionate 100mg/mL 8mL $30.00

Testosterone Propionate 100mg/mL 10mL $35.00

Thiamine HCL 100mg/mL 30mL $30.00

Vitamin B-Complex - 30mL $45.00

Zomacton (lyophilized) - 5mg $348.00

PT 141 10000mcg/mL 2mL $115.00

Sermorelin 2000mcg/mL 7.5mL $85.00

Sermorelin/Glycine 2000mcg/5mg/mL 4mL $85.00

Thymosin Alpha 3000mcg/mL 5mL $150.00

Thymosin Alpha PF 3000mcg/mL 0.2mL $7.50

Thymosin Beta 3000mcg/mL 5mL $150.00

Thymosin Beta PF 3000mcg/mL 0.25mL $7.50

73 CREAMCreamsS AND FOAMS & Foams

PRODUCT POTENCY PRODUCT DOCTOR PRICE VOLUME

Aminophylline / Glycyrrhetinic Acid 0.5%/2.5% 60mL $65.00

Arousal - 5mL $15.00

Arousal - 10mL $30.00

Arousal - 30mL $80.00

Benzocaine/Lidocaine/Tetracaine 20%/20%/20% 30mL $25.00

Benzocaine/Lidocaine/Tetracaine 20%/6%/4% 60mL $36.00

Biest 80/20 0.375mg/mL 30mL $30.00

Biest 80/20 2mg/mL 30mL $30.00

Biest 80/20/Progesterone 1mg/30mg 30mL $35.00

Biest 80/20/Progesterone/Testosterone/DHEA 2.5/200/4/10mg 30mL $45.00

Biest 80/20/Testosterone 8/12mg/mL 30mL $25.00

DHEA 25mg/mL 30mL $10.00

DHEA/Pregnenolone 100/100mg 30mL $30.00

Estradiol 0.5mg/mL 30mL $25.00

Estradiol 1mg/mL 30mL $25.00

Estradiol 1.5mg/mL 30mL $25.00

Estradiol 2mg/mL 30mL $25.00

Estradiol 2.5mg/mL 30mL $25.00

Estradiol 3mg/mL 30mL $25.00

Estradiol 4mg/mL 30mL $25.00

Estradiol 5mg/mL 30mL $25.00

Estradiol 6mg/mL 30mL $25.00

Estradiol 7mg/mL 30mL $25.00

Estradiol 8mg/mL 30mL $25.00

Estradiol 10mg/mL 30mL $25.00

Estradiol 12mg/mL 30mL $25.00

Estradiol 14mg/mL 30mL $25.00

Estradiol 15mg/mL 30mL $25.00

Estradiol/DHEA/Testosterone 0.1/0.5/5mg/mL 30mL $35.00

Estradiol/Estriol 2.4/0.6mg/mL 30mL $30.00

Estradiol/Estriol/Testosterone/Progesterone/ 2/0.5/2.5/200/10mg 30mL $45.00 74 DHEA /mL

Estradiol/Progesterone 0.5/1mg/mL 30mL $30.00

Estradiol/Testosterone 0.1/5mg/mL 30mL $30.00

Estradiol/Testosterone 1/6mg/mL 30mL $30.00

Estradiol/Testosterone 24/20mg/mL 15mL $15.00

Estriol 0.5mg/mL 30mL $25.00

Estriol/Estradiol 50/50 4mg/mL 30mL $30.00

Estriol/Estradiol 50/50 7mg/mL 30mL $30.00

Estriol/Estradiol 50/50 10mg/mL 30mL $30.00

Estriol/Estradiol 80/20 DHEA 2.5mg/25mg 30mL $35.00

Glutathione 200mg/mL 30mL $39.00

Hydroquinone 10% 60mL $25.00

KPV 1mg/mL 30mL $55.00

Lidocaine 25% 50mL $36.00

Lidocaine/Phenyl/Prilocaine 15/5/0.5% 30mL $55.00

Minoxidil/Finasteride 5/0.1% 30mL $60.00

Minoxidil/Finasteride 10/ 0.1% 30mL $60.00

Ostarine Transdermal 600mcg/mL 30mL $125.00

Progesterone 100mg/mL 30mL $25.00

Progesterone 10mg/mL 30mL $25.00

Progesterone 15mg/mL 30mL $25.00

Progesterone 25mg/mL 30mL $25.00

Progesterone 30mg/mL 30mL $25.00

Progesterone 50mg/mL 30mL $25.00

Scream Cream (Cituliine/Aminophilline/Ergoloid 120mg/30mg/0.5mg 5mL $20.00 Mesylate/Pentoxifylline) /50mg

Testosterone 1mg/mL 30mL $25.00

Testosterone 3mg/mL 30mL $25.00

Testosterone 10mg/mL 30mL $25.00

Testosterone 15mg/mL 30mL $25.00

Testosterone 100mg/mL 30mL $25.00

Testosterone 200mg/mL 30mL $25.00

Testosterone 250mg/mL 30mL $25.00

Trimix Gel (Alprostadil/Papaverine/Phentolamine) 10mg/30mg/0.5mg 15mL $135.00 ​ 75 Troches & Gummies

TROCHES & GUMMIES

PRODUCT POTENCY DOCTOR PRICE

Bi-est (50:50) 2mg $1.20

Estradiol/Progesterone 1/100mg $1.75

Estriol/Estradiol 50/50 1.25mg $1.20

Estriol/Estradiol 50/50 16mg $2.00

Estriol/Estradiol 50/50 4mg $1.30

Oxandrolone 2.5mg $1.10

Oxandrolone 5mg $1.10

Oxytocin 20IU $1.00

Oxytocin 40IU $1.25

Oxytocin 100IU $1.50

Oxytocin 800IU $3.67

Pregnenolone 25mg $1.50

Pregnenolone/Progesterone 25/25mg $2.00

Progesterone 100mg $1.50

Progesterone 200mg $2.00

Sermorelin 500mcg $1.92

Sildenafil 50mg $4.00

Sildenafil 60mg $4.00

Sildenafil 100mg $4.00

Sildenafil 150mg $5.00

Tadalafil 5mg $3.00

Tadalafil (Gummy) 6mg $2.50

Tadalafil 10mg $3.00

Tadalafil 15mg $3.00

Tadalafil 20mg $4.00

Tadalafil 25mg $4.00

Tadalafil (Gummy) 25mg $3.50

Tadalafil 30mg $4.67

Tadalafil 40mg $4.00

Tadalafil 50mg $5.00 76 Tadalafil 60mg $5.00

Tadalafil 75mg $5.00

Tadalafil/Apomorphine 20mg/4mg $4.15

Tadalafil/Apomorphine 40mg/4mg $4.15

Tadalafil/Apomorphine 40mg/6mg $4.15

Tadalafil/Oxytocin 20mg/125iu $3.00

Tadalafil/Oxytocin/PT 141 10mg/100iu/1000mcg $3.25

Tadalafil/Oxytocin/PT 141 10mg/100iu/2000mcg $4.00

Tadalafil/Oxytocin/PT 141 20mg/100iu/1000mcg $3.50

Tadalafil/Oxytocin/PT 141 20mg/100iu/2000mcg $4.50

Testosterone 100mg $0.75

NANasalSAL & EYE DROPS & Eye Drops

PRODUCT POTENCY PRODUCT DOCTOR METHOD OF VOLUME PRICE ADMINISTRATION

Oxytocin 20IU/0.1mL 3mL $90.00 Nasal

Oxytocin/L-Theanine 20IU/10mg/0.1mL 3mL $72.00 Nasal

PT 141 2.5mg/0.1mL 3mL $150.00 Nasal

Thymosin Beta 0.1% 3mL $150.00 Ocular

Valproic Acid 5% 25mL $35.00 Nasal

77 IV + Protocols IV + PROTOCOLS

PRODUCT POTENCY PRODUCT VOLUME DOCTOR PRICE

Alpha Lipoic Acid 25mg/mL 30mL $55.00

Ascorbic Acid (commercial) 500 mg/mL 50mL $130.00

Ascorbic Acid (non-corn 500 mg/mL 50mL $49.00 derived)

B-Complex 100/100/100/20mg/mL 30mL $45.00

Biotin 5mg/mL 1mL $12.00

Biotin 5mg/mL 2mL $20.00

Biotin 5mg/mL 5mL $20.00

Calcium Chloride 100 mg/mL 10mL $25.00

Calcium Chloride 100 mg/mL 30mL $25.00

Calcium Gluconate 100 mg/mL 50mL $24.00

Cerebrolysin 215mg/mL 4 x 10mL $226.80

Dexpanthenol B5 250mg/mL 30mL $18.00

Edetate Disodium 150mg/mL 10mL $25.00

Folic Acid 5mg/mL 30mL $25.00

GAC 25mcg/100mcg/250mcg/mL 30mL $27.00

Glutamine 30mg/mL 30mL $30.00

Glutathione 200mg/mL 10mL $20.00

Glutathione 200mg/mL 30mL $40.00

GOAL 25/75/150/150mg/mL 30mL $44.00

Hydroxocobalamin 25mg/mL 10mL $30.00

MIC B12 + Carnitine 40/40/1/100 30mL $34.00

L-Carnitine 500mg/mL 30mL $43.00

Lysine 200mg/mL 30mL $50.00

Magnesium Chloride 200mg/mL 50mL $30.00

Magnesium Sulfate 500mg/mL 10mL $30.00

Met Enkephalin (Lyophilized) 10mg - $92.00

Methylcobalamin 1mg/mL 10ml $18.00

Methylcobalamin 10mg/mL 10mL $29.00

Methylcobalamin 10mg/mL 30mL $40.00

MIC B12 25/50/50/1mg/mL 10mL $23.00

78 MIC B12 + Carnitine 10/40/40/1/100mg/mL 10mL $26.00

Myer’s Cocktail 4/0.8/1/0.4/1mg/mL 30mL $55.00

Pentosan Polysulfate Sodium 250mg/mL 10mL $135.00

Procaine HCl 20mg/mL 5mL $10.00

Pyridoxine 100mg/mL 10mL $25.00

Pyridoxine 100mg/mL 30mL $60.00

Taurolidine 2% 250mL $100.00

Temsirolimus 25mg/mL 4mL $48.00

Thiamine HCl 100mg/mL 30mL $30.00

Thymosin Alpha 1 3000mcg/mL 5mL $150.00

Thymosin Beta 4 3000mcg/mL 5mL $150.00

Product IV Protocol

Thymosin Alpha 1 (Zadaxin) This IV is used for immune support. It can be used in a 250mL bag given as a drip or used as a push at the end of a drip with Vitamin C. It has been used in cancer, autoimmune disease, and in viral loads such as flu and cold, as well as lyme disease. It’s indications continue to grow, but are usually not given with much frequency.

Thymosin Beta 4 This is given at a dose of 3-5mg per IV. It can be given as a drip over 25 minutes or combined with other muscle recovery protocols as a push near the end of the drip. It also has good data for helping repair cardiac tissue after a MI, helping with TBI, and muscular repair.

79