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SECTION 1.Identification Product Identifier Product Number 818053 Product Name Sodium Cyanoborohydride for Synthesis CAS-No

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SECTION 1.Identification Product Identifier Product Number 818053 Product Name Sodium Cyanoborohydride for Synthesis CAS-No SAFETY DATA SHEET according to the (US) Hazard Communication Standard (29 CFR 1910.1200) Revision Date 06/11/2018 Version 1.3 SECTION 1.Identification Product identifier Product number 818053 Product name Sodium cyanoborohydride for synthesis CAS-No. 25895-60-7 Relevant identified uses of the substance or mixture and uses advised against Identified uses Chemical for synthesis Details of the supplier of the safety data sheet Company EMD Millipore Corporation | 400 Summit Drive | Burlington | Massachusetts 01803 | United States of America | General Inquiries: +1 800-645-5476 | Monday to Friday, 9:00 AM to 4:00 PM Eastern Time (GMT-5) MilliporeSigma is a business of Merck KGaA, Darmstadt, Germany. Emergency telephone 800-424-9300 CHEMTREC (USA) +1-703-527-3887 CHEMTREC (International) 24 Hours/day; 7 Days/week SECTION 2. Hazards identification GHS Classification Substances and mixtures which in contact with water emit flammable gases, Category 1, H260 Acute toxicity, Category 2, Oral, H300 Acute toxicity, Category 2, Inhalation, H330 Acute toxicity, Category 2, Dermal, H310 Skin corrosion, Category 1B, H314 Serious eye damage, Category 1, H318 For the full text of the H-Statements mentioned in this Section, see Section 16. GHS-Labeling Hazard pictograms Signal Word Danger Page 1 of 12 SAFETY DATA SHEET according to the (US) Hazard Communication Standard (29 CFR 1910.1200) Product number 818053 Version 1.3 Product name Sodium cyanoborohydride for synthesis Hazard Statements H260 In contact with water releases flammable gases which may ignite spontaneously. H300 + H310 + H330 Fatal if swallowed, in contact with skin or if inhaled. H314 Causes severe skin burns and eye damage. Precautionary Statements P223 Keep away from any possible contact with water, because of violent reaction and possible flash fire. P231 + P232 Handle under inert gas. Protect from moisture. P260 Do not breathe dust/ fume/ gas/ mist/ vapors/ spray. P262 Do not get in eyes, on skin, or on clothing. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P284 Wear respiratory protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor. P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303 + P361 + P353 IF ON SKIN (or hair): Remove/ Take off immediately all contaminated clothing. Rinse skin with water/ shower. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a POISON CENTER/doctor. P320 Specific treatment is urgent (see supplemental first aid instructions on this label). P335 + P334 Brush off loose particles from skin. Immerse in cool water/ wrap in wet bandages. P361 Remove/Take off immediately all contaminated clothing. P363 Wash contaminated clothing before reuse. P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol-resistant foam for extinction. P402 + P404 Store in a dry place. Store in a closed container. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. Other hazards None known. SECTION 3. Composition/information on ingredients Formula NaBH₃CN CH₃BNNa (Hill) Molar mass 62.84 g/mol Hazardous ingredients Chemical name (Concentration) CAS-No. sodium cyanoborohydride (>= 90 % - <= 100 % ) 25895-60-7 Exact percentages are being withheld as a trade secret. Page 2 of 12 SAFETY DATA SHEET according to the (US) Hazard Communication Standard (29 CFR 1910.1200) Product number 818053 Version 1.3 Product name Sodium cyanoborohydride for synthesis SECTION 4. First aid measures Description of first-aid measures General advice First aider needs to protect himself. Inhalation After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply artificial respiration, if necessary also oxygen. Skin contact After skin contact: wash off with plenty of water. Immediately remove contaminated clothing. If available swab with polyethylene glycol 400. Call a physician immediately. Eye contact After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses. Ingestion If swallowed: give water to drink (two glasses at most). Seek medical advice immediately. In exceptional cases only, if medical care is not available within one hour, induce vomiting (only in persons who are wide awake and fully conscious), administer activated charcoal (20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible. Do not attempt to neutralize. Never give anything by mouth to an unconscious person. Most important symptoms and effects, both acute and delayed Risk of blindness! The following applies to boron compounds in general: resorption is followed by nausea and vomiting, agitation, spasms, CNS disorders, cardiovascular disorders. The following applies to cyanogen compounds/ nitriles in general: utmost caution! Release of hydrocyanic acid is possible - blockade of cellular respiration. Cardiovascular disorders, dyspnoea, unconsciousness. Irritation and corrosion, Cough, Shortness of breath Indication of any immediate medical attention and special treatment needed No information available. SECTION 5. Fire-fighting measures Extinguishing media Suitable extinguishing media Carbon dioxide (CO2), Dry powder Unsuitable extinguishing media Water, Foam Special hazards arising from the substance or mixture Combustible. May not get in touch with: Water Caution! in contact with water product releases: Hydrogen Forms explosive mixtures with air on intense heating. Page 3 of 12 SAFETY DATA SHEET according to the (US) Hazard Communication Standard (29 CFR 1910.1200) Product number 818053 Version 1.3 Product name Sodium cyanoborohydride for synthesis Vapors are heavier than air and may spread along floors. Development of hazardous combustion gases or vapors possible in the event of fire. Fire may cause evolution of: nitrogen oxides, Hydrogen cyanide (hydrocyanic acid) Advice for firefighters Special protective equipment for fire-fighters Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing. Further information Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system. SECTION 6. Accidental release measures Personal precautions, protective equipment and emergency procedures Advice for non-emergency personnel: Avoid generation and inhalation of dusts in all circumstances. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: Protective equipment see section 8. Environmental precautions Do not let product enter drains. Risk of explosion. Methods and materials for containment and cleaning up Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid generation of dusts. SECTION 7. Handling and storage Precautions for safe handling Observe label precautions. Work under hood. Do not inhale substance/mixture. Avoid generation of vapors/aerosols. Advice on protection against fire and explosion Keep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharge. Conditions for safe storage, including any incompatibilities Tightly closed. Keep away from heat and sources of ignition. Keep locked up or in an area accessible only to qualified or authorized persons. Store below +30°C (+86°F). Page 4 of 12 SAFETY DATA SHEET according to the (US) Hazard Communication Standard (29 CFR 1910.1200) Product number 818053 Version 1.3 Product name Sodium cyanoborohydride for synthesis SECTION 8. Exposure controls/personal protection Exposure limit(s) Ingredients Basis Value Threshold Remarks limits sodium cyanoborohydride 25895-60-7 NIOSH/GUIDE Ceiling Limit Value and 4.7 ppm Ceiling Limit Value 10-min Time Period (if 5 mg/m³ Expressed as: as CN specified): OSHA_TRANS PEL: 5 mg/m³ Expressed as: as CN Skin designation: Can be absorbed through the skin. Expressed as: as CN Z1A Time Weighted Average 5 mg/m³ Expressed as: as CN (TWA): ACGIH Short Term Exposure 6 mg/m³ Form of exposure: Inhalable fraction. Limit (STEL): Time Weighted Average 2 mg/m³ Form of exposure: Inhalable fraction. (TWA): Engineering measures Technical measures and appropriate working operations should be given priority over the use of personal protective equipment. Individual protection measures Protective clothing should be selected specifically for the workplace, depending on concentration and quantity of the hazardous substances handled. The chemical resistance of the protective equipment should be inquired at the respective supplier. Hygiene measures Immediately change contaminated clothing. Apply skin- protective barrier cream. Wash hands and face after working with substance. Eye/face protection Tightly fitting safety goggles
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