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Carpenter Presentation Apr 2014 Heoc2 National Aeronautics and Space Administration NASA Advisory Council Human Exploraon and Operaons Commi:ee Research Subcommittee Report One Year Study and Genome Project Bradley M. Carpenter, PhD. Chief Scien7st, Space Life and Physical Sciences Human Exploraon & Operaons Mission Directorate Biological and Physical Sciences • NASA's Space Life and Physical Sciences Research and Applications Division (SLPS) has been formulated to execute high quality, high value research and application activities in the areas of: – Space Biology – Physical Sciences – Human Research • These programs conduct fundamental and applied research to advance basic knowledge and to support human exploration in the environment of space. • Division serves as the Agency liaison with the ISS National Laboratory management organization, the Center for the Advancement of Science in Space (CASIS). SLPS Research and Application Focus Areas Space Biology Human Research Physical Sciences • Uses the space environment • Develops scientific and • Conducts fundamental and to enhance understanding of technological foundations applied research in space to the response of living for a safe, productive explore the processes that organisms and biological human presence in space form materials and processes to spaceflight for extended periods. determine the performance conditions. of fluid, thermal, and • Focuses on investigating combustion systems. • Works toward an and mitigating the highest understanding of the risks to human health and • Builds engineering requirements of terrestrial life performance in order to knowledge to enable the in non-Earth environments. enable safe, reliable, and design of fluid, thermal, and Provides access to model productive human space chemical process devices biomedical research systems. exploration. for future space exploration systems. • Applies this knowledge and technology to improve our Nation's competitiveness, education and the quality of life on Earth. Creates the new discoveries for CASIS activities. 3 SLPSRA Organization Chart RMO Lead SLPS ISSPO (OZ) NASA Chief (Leck) Porterfield, Director Scien7st Office (Jones/ Conover) Otero, Deputy Director (Stofan) HRP Program Office CASIS Liaison (Paloski/JSC) (Carpenter) LPS Chief Scien7st (Carpenter) ISS POC (Otero) Physical Sciences Physical Sciences Human Research (Fluids, Materials, Space Biology Combuson, (Fundamental Physics) Biophysics) Science Content Science Content Science Content Science Content (Davison (Chiaramonte) (Lee) (Tomko)(Rayl, detailee) / Hather) Flight Hardware Flight Hardware Flight Hardware (Otero) Resource Analyst (Jackson) (Otero) (Otero) Resource Analyst Resource Analyst Resource Analyst (Jackson) (Jackson) (Jackson) 4 NASA Human Research Program (HRP) Mission • To enable space exploration beyond low Earth orbit by reducing the risks to human health & performance through a focused program of basic, applied, and operational research Goals • Perform research necessary to understand and reduce spaceflight human health and performance risks in support of exploration • Develop and validate technologies that serve to characterize and reduce medical risks associated with human spaceflight • Enable development of human spaceflight medical and performance standards 5 Integrated Human Health Risk Mitigation • Policy, Operations, and Research are integrated through a Human Health Risk Framework - Office of the Chief Health and Medical Officer (OCHMO) • Medical Policy, Health and Performance Standards, and Bioethics (IRB, ACUC, Risk OCHMO Threshold) - Crew Health and Safety (CHS) • Medical Operations and Occupational Health (career health care/post career monitoring) CHS HRP - NASA Human Research Program (HRP) • Human health & performance research in support of space exploration ISS - Perform research necessary to understand & reduce health & performance risks – International Space Station (ISS) • Medical Operations on ISS – Medical Tests and hardware 6 Overview: Organization Directorate Program Human Exploraon and Operaons Agency Program Management Council Mission Directorate Management Council (DPMC) (AA) (APMC) Office of the Chief Scien7st Office of the Chief Health & Medical Officer Office of the Chief Space Life Sciences & (OCHMO) Technologist (OCT) Physical Sciences Research & Applicaons HQ Centers Human Research Program Naonal Space (HRP) JSC Chief Biomedical Research Medical Officer Ins7tute Program Manager (NSBRI) Deputy Program Manager Director/Scien1st Chief Scien1st JSC Commi:ee for Deputy Chief Scien1st the Protec7on of Human Subjects Internaonal Science Office (ISO) Chief Human Research Program Integraon Office (PIO) Human Research Science Manager/Deputy Manager Management Office (SMO) Manager/Deputy Manager Behavioral Health Human Health Space Human Space Radiaon Exploraon ISS Medical and Performance Countermeasures Factors and (SR) Medical Capability Projects (BHP) (HCC) Habitability Manager/Scien1st (ExMC) (ISSMP) Manager/Scien1st Manager/Scien1st (SHFH) Manager/Scien1st Manager/Scien1st Manager/Scien1st Hazards Create Risks During Space Flight Space Flight Hazards to Crew Members: decreased gravity/gravity transitions* bone, muscle, cardiovascular, sensory-motor, nutrition, immunology, human factors, clinical medicine isolation/confinement* behavior/performance, nutrition, immunology, toxicology, microbiology altered light-dark cycles* behavior/performance increased radiation* carcinogenesis, tissue degeneration(cardiovascular), CNS effects, acute (SPEs) distance from Earth behavior/performance, autonomy, food systems, clinical medicine *effect severity increases with mission duration 8 International Coordination: Exploration Biomedical Challenges Not mission Not Potentially Mission limiting, but Human Health and Performance Risks mission Mission increased limiting limiting Coordinated with all International Partners ISS Lunar NEA Mars risk 6 mo 6 mo (1yr) (3yr) Long-term health risk of Early Onset Osteoporosis; Musculoskeletal Mission risk of reduced muscle strength and aerobic capacity Sensorimotor Mission risk of sensory changes/dysfunctions Mission and long-term health risk of Microgravity-Induced Visual U U Ocular Impairment Impairment and/or elevated Intracranial Pressure (VIIP) Mission risk of behavioral and nutritional health due to inability to Nutrition provide appropriate quantity, quality and variety of food Mission health risk due to inability to provide adequate medical Autonomous Medical Care care throughout the mission (Includes onboard training, diagnosis, treatment, and presence/absence of onboard physician) Behavioral Health and Mission and long-term behavioral health risk. Performance Long-term risk of carcinogenesis and degenerative tissue disease Space Radiation due to radiation exposure Mission risk of exposure to a toxic environment without adequate Toxicity monitoring, warning systems or understanding of potential toxicity (dust, chemicals, infectious agents) Medical risks due to life support system failure and other Autonomous Emergency emergencies (fire, depressurization, toxic atmosphere, etc.), crew Response rescue scenarios Long-term risk associated with adaptation during IVA and EVA on U Hypogravity the Moon, asteroids, Mars (vestibular and performance dysfunctions) and post-flight rehabilitation 9 Integrated Human Health Risk Reduction Schedule • HRP initial assessment Asteroid - Mars - ISS12 Phase A EM-1 ISS End EM-2 Exp EMU Asteroid Phase A DSH-Mars SRR Initiative Possible ISS Extension MARS FY13 FY14 FY15 FY16 FY17 FY18 FY19 FY20 FY21 FY22 FY23 FY24 FY25 FY26 FY27 FY28 Task Renal CM Validated Legend DCS Risk Understood CM Validated HCI HRP Risk CM Dev Sleep Risk Understood CM Validated Requires ISS ARS Microhost Risk Understood Risk Understood HRP Risk Hab Tool Developed Model Developed Risk Understood ISS Not Immune Risk Understood CM Identified CM Validated Required OI Risk Understood CM Validated Fracture Risk Understood CM Validated Sensorimotor Risk Understood CM Identified CM Validated Milestone Train uses ISS HARI CM Identified Osteo Risk Understood CM Validated Team CM Developed Risk Understood CM Validated EVA Milestone slip Pharm Risk Understood CM Identified due to Nutrition Risk Understood CM Identified CM Validated insufficient Food Risk Understood Technology Developed Technology Validated “N” on ISS VIIP Risk Understood CM Validated Aerobic Risk Understood CM Identified Muscle Risk Understood CM Identified CM Validated CM Developed Risk Rating ExMC Risk Understood CM Validated Bmed Risk Understood CM Validated Cancer Unacceptable OP IVD Risk Verified Risk Understood v CM Developed Acceptable Arrhythmia Risk Verified CM Validated Degen Controlled CNS Dust Research plan has not yet been defined to address this DRM Insufficient Data FY13 FY14 FY15 FY16 FY17 FY18 FY19 FY20 FY21 FY22 FY23 FY24 FY25 FY26 FY27 FY28 Response to the Decadal Survey: Perspectives and Approaches for Going Forward • Chartered by Congress the National Academy of Science Commissioned a National Research Council decadal survey of NASA Life and Physical Sciences • The Resulting report serves the SLPS Division in HEO as a guideline for developing applied and fundamental research that serves to promote the NASA human exploration mission • Decadal recommendations serve the ultimate direction in prioritization of ISS research efforts coming from the SLPS Division at HQ • NASA/SLPS is directly responsible back to the NAS/NRC and congress in how the recommendations are addressed. 11 Recapturing a Future for Space Exploration: Life and Physical Sciences Research
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