Eighth World Congress on Alternatives and Animal Use in the Life Sciences Hosted by the Canadian Council on Animal Care 2011 MONTRÉAL (CANADA) August 21-25, 2011 The Three Rs Together It’s Possible Final Program Replacement • Reduction • Refinement TABLE OF CONTENTS Welcome ........................................................................................................................4 Congress Committees .................................................................................................5 Acknowledgements .......................................................................................................6 Awards and Grants ........................................................................................................8 Practical Information ...................................................................................................11 About Montréal ....................................................................................................11 General Information..............................................................................................13 Registration .........................................................................................................15 Information for Chairs, Presenters and Exhibitors .................................................16 Convention Floor Plan ..........................................................................................17 Social Program .............................................................................................................19 Scientific Program .......................................................................................................20 Program Overview ................................................................................................20 Sunday, August 21 (Pre-Congress Satellite Meetings) .....................................21 Monday, August 22 .........................................................................................22 Tuesday, August 23 ........................................................................................24 Wednesday, August 24 ...................................................................................26 Thursday, August 25 .......................................................................................28 Scientific Sessions ...............................................................................................29 Monday, August 22 .........................................................................................29 Tuesday, August 23 ........................................................................................39 Wednesday, August 24 ...................................................................................50 Poster Sessions ................................................................................................... 62 OF CONTENTS TABLE Monday, August 22 .........................................................................................62 Tuesday, August 23 .........................................................................................70 Wednesday, August 24 ...................................................................................90 Exhibitions ..................................................................................................................104 Multimedia Exhibition of Alternatives in Education and Training ...........................104 Exhibiting Companies and Associations ..............................................................105 Indexes ........................................................................................................................107 Index of Chairs and Presenters ...........................................................................107 Index of Sessions ...............................................................................................110 3 2011 WELCOME Dear WC8 participants, The Canadian Council on Animal Care (CCAC) is proud to be the first national authority overseeing animal use in science to be given the opportunity to host a World Congress on Alternatives and Animal Use in the Life Sciences (WC). This honour recognizes Canada’s, and more especially the CCAC’s, contributions to the area of refinement of animal use in science. Since its establishment in 1968, the CCAC has continuously encouraged the development and adoption of best practices in animal care and use in science, a central theme at the WC3 in 1999 when the Three Rs Declaration of Bologna was adopted. So, while advances in vitro methods, particularly for regulatory testing, remain a main focus of the WCs, in keeping with the spirit of Bologna, the 8th World Congress on Alternatives and Animal Use in the Life Sciences (WC8) will also have an emphasis on refinement of laboratory animal use. In addition, through greater involvement of scientists from both the biomedical and biological sciences, the WC8 will chart new territory in examining the Three Rs as applied to basic research. Following on from the 7th World Congress Calling on Science, the WC8 will provide a forum that supports quality science and recognizes the increasing need for an integrated approach to human, animal and environmental health. In Canada, policy on the use of animals in science is developed with input from scientific researchers and teachers, veterinarians, animal care staff, regulators and the public. This tradition of consensus-building inspired the WC8 motto “The Three Rs – Together it’s Possible”. The goal of the WC8 is to bridge the distance between science, policy and education by identifying mechanisms to enable effective knowledge transfer and the translation of science-based evidence into good animal practices and non-animal alternatives that will result in higher quality science. The WC8 brings together close to 900 professionals, including researchers, veterinarians, animal welfare organizations, public representatives, members of institutional animal care and use/ethics committees, and regulatory experts. These participants will join us from more than 50 countries for the unique opportunity to exchange scientific, ethical, and animal welfare knowledge, further progressing the ethical principles of the Three Rs (Refinement, Replacement and Reduction) enunciated by Russell and Burch in 1959. We are pleased to host the WC8 in Montréal’s most hospitable and gracious hotel — Fairmont The Queen Elizabeth — located at the center of Montréal’s vibrant cultural and commercial district. The hotel reflects Montréal’s elegance and charm. It is connected to the extensive underground city of boutiques, restaurants and cafés and is within walking distance of sports and cultural attractions. As Co-Chairs of the WC8, we extend a warm welcome to all the participants and accompanying persons. We look forward to an opportunity to reconnect with old acquaintances and to make new friends with a view to working together to advancing Three Rs in science and education. Sincerely, WELCOME Clément Gauthier Herman Koëter Executive Director, CCAC Managing Director, Orange House Partnership Co-Chairs, Eighth World Congress on Alternatives and Animal Use in the Life Sciences 4 CONGRESS COMMITTEES CONGRESS CO-CHAIRS STEERING COMMITTEE ALTERNATIVE CONGRESS TRUST Clément Gauthier, Canada Gilly Griffin, Canada Michael Balls, UK Herman Koëter, Belgium Coenraad Hendriksen, Netherlands Thomas Hartung, USA Robert Kavlock, USA Coenraad Hendriksen, Netherlands Yasuo Ohno, Japan Herman Koëter, Belgium Andrew Rowan, USA Andrew Rowan, USA Adrian Smith, Norway Horst Spielmann, Germany Michel Tremblay, Canada Emeritus Trustees Alan Goldberg, USA Bert van Zutphen, Netherlands SCIENTIFIC PROGRAM COMMITTEE François Auger, Canada David Mellor, New Zealand Fernando Benavides, USA Tsutomu Miki Kurosawa, Japan Andrew Bennett, UK Frauke Ohl, Netherlands Bas Blaauboer, Netherlands Jon Richmond, UK David Blakey, Canada Merel Ritskes-Hoitinga, Netherlands Geoff Dandie, Australia Vera Rogiers, Belgium Fraser Darling, UK Margaret Rose, Australia David Dewhurst, UK Adrian Smith, Norway Suzanne Fitzpatrick, USA Martin Stephens, USA Gilly Griffin, Canada (Chair) William Stokes, USA Carol Howard, USA Mark Torchia, Canada Richard Isbrucker, Canada Michel Tremblay, Canada CONGRESS COMMITTEES Maggy Jennings, UK Patricia Turner, Canada Nick Jukes, UK Jan van der Valk, Netherlands Hajime Kojima, Japan Tamara Vanhaecke, Belgium Marcel Leist, Germany Dan Weary, Canada Lyne Létourneau, Canada Carl Westmoreland, UK Paul Locke, USA Hanno Würbel, Germany Susanna Louhimies, Belgium Joanne Zurlo, USA Richard McFarland, USA ORGANIZING SECRETARIAT Eighth World Congress Secretariat 1510-130 Albert St. Ottawa ON CANADA K1P 5G4 email: [email protected] 5 2011 ACKNOWLEDGEMENTS The World Congress Co-Chairs and the Alternatives Congress Trust would like to express their gratitude to all those who are generously supporting the Eighth World Congress on Alternatives and Animal Use in the Life Sciences (WC8). PLATINUM SPONSORS AND PATRONS OF THE WC8 GOLD SPONSORS AND BENEFACTORS SILVER SPONSORS BRONZE SPONSORS SUPPORTERS Canadian Association for Laboratory Animal Medicine Canadian Association for Laboratory Animal Science Canadian Federation of Humane Societies Canadian Veterinary Medical Association Charles River Colgate Palmolive Laboratory Animals Limited Merck Animal Health Novozymes Society of Toxicology The American Society for the Prevention of Cruelty to Animals ACKNOWLEDGEMENTS The Association of Primate