Sun Solvent Blend Version 1.2 Revision Date: 09/01/2019

Total Page:16

File Type:pdf, Size:1020Kb

Sun Solvent Blend Version 1.2 Revision Date: 09/01/2019 Safety Data Sheet Sun Solvent Blend Version 1.2 Revision Date: 09/01/2019 SECTION 1. PRODUCT AND COMPANY IDENTIFICATION Product name : Sun Solvent Blend Recommended use of the chemical and restrictions on use Recommended use : Solvent. Manufacturer or supplier's details Company : Univar Solutions USA, Inc. Address 3075 Highland Pkwy Suite 200 Downers Grove, IL 60515 United States of America (USA) Emergency telephone number: Transport North America: CHEMTREC (1-800-424-9300) CHEMTREC INTERNATIONAL Tel # 703-527-3887 Additional Information: : Responsible Party: Product Compliance Department E-mail: [email protected] SDS Requests: 1-855-429-2661 Website: www.univarsolutions.com SECTION 2. HAZARDS IDENTIFICATION GHS Classification Flammable liquids : Category 2 Skin irritation : Category 2 Serious eye damage : Category 1 Skin sensitisation : Category 1 Specific target organ toxicity : Category 3 (Respiratory system, Central nervous system) - single exposure GHS label elements Hazard pictograms : Signal word : Danger Hazard statements : H225 Highly flammable liquid and vapour. H315 Causes skin irritation. H317 May cause an allergic skin reaction. H318 Causes serious eye damage. H335 May cause respiratory irritation. H336 May cause drowsiness or dizziness. Precautionary statements : Prevention: SDS Number: 100000020960 1 / 13 Sun Solvent Blend Safety Data Sheet Sun Solvent Blend Version 1.2 Revision Date: 09/01/2019 P210 Keep away from heat/sparks/open flames/hot surfaces. No smoking. P233 Keep container tightly closed. P240 Ground/bond container and receiving equipment. P241 Use explosion-proof electrical/ ventilating/ lighting equip- ment. P242 Use only non-sparking tools. P243 Take precautionary measures against static discharge. P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/ eye protection/ face protection. Response: P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P305 + P351 + P338 + P310 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/doctor. P333 + P313 If skin irritation or rash occurs: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P370 + P378 In case of fire: Use dry sand, dry chemical or alco- hol-resistant foam to extinguish. Storage: P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P403 + P235 Store in a well-ventilated place. Keep cool. P405 Store locked up. Disposal: P501 Dispose of contents/ container to an approved waste dis- posal plant. Other hazards None known. SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS Substance / Mixture : Mixture Hazardous components CAS-No. Chemical name Weight percent 67-63-0 Isopropyl alcohol 30 - 50 78-83-1 Isobutanol 30 - 50 108-11-2 Methyl amyl alcohol 20 - 30 108-10-1 Methyl isobutyl ketone 0.1 - 1 Any Concentration shown as a range is due to batch variation. SDS Number: 100000020960 2 / 13 Sun Solvent Blend Safety Data Sheet Sun Solvent Blend Version 1.2 Revision Date: 09/01/2019 SECTION 4. FIRST AID MEASURES General advice : Move out of dangerous area. Consult a physician. Show this safety data sheet to the doctor in attendance. Do not leave the victim unattended. If inhaled : Consult a physician after significant exposure. If unconscious, place in recovery position and seek medical advice. In case of skin contact : If skin irritation persists, call a physician. If on skin, rinse well with water. If on clothes, remove clothes. In case of eye contact : Take victim immediately to hospital. Small amounts splashed into eyes can cause irreversible tis- sue damage and blindness. In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Continue rinsing eyes during transport to hospital. Remove contact lenses. Protect unharmed eye. Keep eye wide open while rinsing. If eye irritation persists, consult a specialist. If swallowed : Keep respiratory tract clear. Do NOT induce vomiting. Do not give milk or alcoholic beverages. Never give anything by mouth to an unconscious person. If symptoms persist, call a physician. Take victim immediately to hospital. SECTION 5. FIREFIGHTING MEASURES Suitable extinguishing media : Alcohol-resistant foam Carbon dioxide (CO2) Dry chemical Unsuitable extinguishing : High volume water jet media Specific hazards during fire- : Do not allow run-off from fire fighting to enter drains or water fighting courses. Hazardous combustion prod- : No hazardous combustion products are known ucts Specific extinguishing meth- : Use a water spray to cool fully closed containers. ods SDS Number: 100000020960 3 / 13 Sun Solvent Blend Safety Data Sheet Sun Solvent Blend Version 1.2 Revision Date: 09/01/2019 Further information : Collect contaminated fire extinguishing water separately. This must not be discharged into drains. Fire residues and contaminated fire extinguishing water must be disposed of in accordance with local regulations. For safety reasons in case of fire, cans should be stored sepa- rately in closed containments. Special protective equipment : Wear self-contained breathing apparatus for firefighting if nec- for firefighters essary. SECTION 6. ACCIDENTAL RELEASE MEASURES Personal precautions, protec- : Use personal protective equipment. tive equipment and emer- Ensure adequate ventilation. gency procedures Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentra- tions. Vapours can accumulate in low areas. Environmental precautions : Prevent product from entering drains. Prevent further leakage or spillage if safe to do so. If the product contaminates rivers and lakes or drains inform respective authorities. Methods and materials for : Contain spillage, and then collect with non-combustible ab- containment and cleaning up sorbent material, (e.g. sand, earth, diatomaceous earth, ver- miculite) and place in container for disposal according to local / national regulations (see section 13). SECTION 7. HANDLING AND STORAGE Advice on protection against : Do not spray on a naked flame or any incandescent material. fire and explosion Take necessary action to avoid static electricity discharge (which might cause ignition of organic vapours). Use only explosion-proof equipment. Keep away from open flames, hot surfaces and sources of ignition. Advice on safe handling : Avoid formation of aerosol. Do not breathe vapours/dust. Avoid exposure - obtain special instructions before use. Avoid contact with skin and eyes. For personal protection see section 8. Smoking, eating and drinking should be prohibited in the ap- plication area. Take precautionary measures against static discharges. Provide sufficient air exchange and/or exhaust in work rooms. Open drum carefully as content may be under pressure. To avoid spills during handling keep bottle on a metal tray. Dispose of rinse water in accordance with local and national regulations. SDS Number: 100000020960 4 / 13 Sun Solvent Blend Safety Data Sheet Sun Solvent Blend Version 1.2 Revision Date: 09/01/2019 Conditions for safe storage : No smoking. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Observe label precautions. Electrical installations / working materials must comply with the technological safety standards. SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Components with workplace control parameters CAS-No. Components Value type Control parame- Basis (Form of ters / Permissible exposure) concentration 67-63-0 Isopropyl alcohol TWA 200 ppm ACGIH STEL 400 ppm ACGIH TWA 400 ppm NIOSH REL 980 mg/m3 ST 500 ppm NIOSH REL 1,225 mg/m3 TWA 400 ppm OSHA Z-1 980 mg/m3 TWA 400 ppm OSHA P0 980 mg/m3 STEL 500 ppm OSHA P0 1,225 mg/m3 78-83-1 Isobutanol TWA 50 ppm ACGIH TWA 50 ppm NIOSH REL 150 mg/m3 TWA 100 ppm OSHA Z-1 300 mg/m3 TWA 50 ppm OSHA P0 150 mg/m3 108-11-2 Methyl amyl alcohol TWA 25 ppm ACGIH STEL 40 ppm ACGIH ST 40 ppm NIOSH REL 165 mg/m3 TWA 25 ppm NIOSH REL 100 mg/m3 TWA 25 ppm OSHA Z-1 100 mg/m3 STEL 40 ppm OSHA P0 165 mg/m3 TWA 25 ppm OSHA P0 100 mg/m3 108-10-1 Methyl isobutyl ketone TWA 20 ppm ACGIH STEL 75 ppm ACGIH TWA 50 ppm NIOSH REL 205 mg/m3 ST 75 ppm NIOSH REL SDS Number: 100000020960 5 / 13 Sun Solvent Blend Safety Data Sheet Sun Solvent Blend Version 1.2 Revision Date: 09/01/2019 300 mg/m3 TWA 100 ppm OSHA Z-1 410 mg/m3 TWA 50 ppm OSHA P0 205 mg/m3 STEL 75 ppm OSHA P0 300 mg/m3 Personal protective equipment Respiratory protection : No personal respiratory protective equipment normally re- quired. In the case of vapour formation use a respirator with an ap- proved filter. Hand protection Remarks : The suitability for a specific workplace should be discussed with the producers of the protective gloves. Eye protection : Eye wash bottle with pure water Tightly fitting safety goggles Wear face-shield and protective suit for abnormal processing problems. Skin and body protection : Impervious clothing Choose body protection according to the amount and concen- tration of the dangerous
Recommended publications
  • Isobutanol in Marine Gasoline
    Isobutanol in Marine Gasoline Glenn Johnston July 11, 2017 Bioeconomy 2017 Washington D.C. 1B: Drivers for Emergence of Biofuels for Maritime Industry © 2012 Gevo, Inc. | 1 Gevo’s Current Business System Gevo Production Facilities Core Near Term Markets Isobutanol Production – Side-by-Side with Ethanol Drop-in Markets - Isobutanol Luverne, MN Isobutanol Specialty Chemicals & Solvents Specialty Gasoline Blendstock (Marine/Off-Road) 15 MGPY EtOH 1.5 MGPY IBA* Isobutanol Hydrocarbon Biorefinery Drop-in Markets - Hydrocarbons South Hydrocarbons Hampton Jet Fuel Resources Silsbee, TX Isooctane (gasoline) © 2016 Gevo, Inc. | 2 Isobutanol Properties Gasoline blending value Gasoline Ethanol Isobutanol RON 95 109 105 MON 85 90 91 Anti-knock Index 90 100 98 RVP (psi) 7-15 19 5.2 Density 20C [kg/m3] 720-775 794 801 Boiling Point (C) 32.2 21.1 26.6 % Heating Value of Gasoline 100 66 84 Oxygen (%w/w) <2.7% 34.7 21.6 isobutanol has low RVP, enabling refiners to blend incremental volumes of butanes and pentanes Marine Research Overview Marine Engine Tested – BRP Envinrude and SeaDoo, Mercury, Volvo-Penta, Yamaha, Tohatsu, Indmar, OMC-Johnson, Honda. Marine Biobutanol over 5 years of research -Alternative Fuel Butanol: Preliminary Investigation on Performance and Emissions of a Marine Two-Stroke Direct Fuel Injection Engine -Impact of Blending Gasoline with lsobutanol Compared to Ethanol on Efficiency, Performance and Emissions of a Recreational Marine 4-Stroke Engine -Gaseous and Particulate Emissions Using Isobutanol-Extended Fuel in Recreational Marine
    [Show full text]
  • Next Generation Biofuels
    Photo-Synthetic Biology for Fuels James C. Liao Chemical and Biomolecular Engineering University of California, Los Angeles The Current Biofuel Cycle CO2 CO2 Ethanol Biodiesel The Direct Solar Fuel Cycle CO2 CO2 Higher Alcohols Biofuels Long chain Ethanol alcohols/alkanes Energy content Low High Hygroscopicity High Low Vehicle Yes No retrofitting? Vapor pressure High Low Production High Zero/Low yield Higher alcohols Native producers? yes Iso-propanol no n-propanol yes n-butanol no Iso-butanol no 2-methyl-1-butanol no 3-methyl-1-butanol Pathways for alcohol synthesis CoA-dependent pathway Pyruvate PDH NADH Acetyl-CoA Acetaldehyde NADH NADH ADH Acetoacetyl-CoA Ethanol 3-Hydroxybutyryl-CoA Crotonyl-CoA Butyryl-CoA Butyraldehyde n-Butanol Alternative Pathways to Make Alcohols CoA-dependent pathway Pyruvate Non-CoA pathway PDH NADH PDC Acetyl-CoA Acetaldehyde NADH NADH ADH ? Acetoacetyl-CoA Ethanol 3-Hydroxybutyryl-CoA Crotonyl-CoA Butyryl-CoA Butyraldehyde n-Butanol Atsumi et al. Nature 2008 Generalization of keto acid decarboxylase chemistry Longer chain keto acids A simple keto acid Pyruvate 2-keto acid PDC KDC Acetylaldehyde R-aldehyde ADH ADH Ethanol R-OH Ehrlich, F. Ber. Dtsch. Chem. Ges.1907 Opening the active site Zymomonas mobilis PDC Lactococcus lactis KdcA E.coli Long Chain 2-keto acids KDC 2-keto acids) R-aldehyde ADH 2008 2-phenylethanol (from Nature 3-M-1-butanol et al. 2-M-1-butanol p henylpyruvate Atsumi Production of Higher Alcohols1-butanol in 2-keto-4-methyl-pentanoate 2-keto-3-methyl-valerate isobutanol 2-ketovalerate 1-propanol 2-ketoisovalerate Production (mM) Production 2-ketobutyrate ํC 40hr 30 Further generalization of alcohol‐ producing chemistry Atsumi et al.
    [Show full text]
  • Method MD-99 Polar Volatile Organic Compounds in Pulp Industry Wastewaters by Microdistillation and GC-FID
    NCASI METHOD MD-99 POLAR VOLATILE ORGANIC COMPOUNDS IN PULP INDUSTRY WASTEWATERS BY MICRODISTILLATION AND GC-FID NCASI West Coast Regional Center Organic Analytical Program July 1999 Acknowledgments This method is authored by Alex Gholson, Senior Research Scientist, and Dean Hoy, Research Associate, with assistance from Diana Cook, Senior Research Scientist, all of NCASI West Coast Regional Center. Mark Bruce of Wadsworth Alert Labs (now Quanterra) developed the microdistillation technique and also provided valuable input during development of this method. For more information about this method, contact: Alex Gholson, Ph.D. John Pinkerton, Ph.D. Senior Research Scientist Vice President, Air Quality NCASI West Coast Regional Center NCASI P.O. Box 458 P.O. Box 13318 Corvallis, OR 97339 Research Triangle Park, NC 27709 (541) 752-8801 (919) 558-1992 [email protected] [email protected] For information about NCASI publications, contact: Publications Coordinator NCASI PO Box 13318 Research Triangle Park, NC 27709 (919) 558-1999 [email protected] National Council for Air and Stream Improvement, Inc. (NCASI). 2000. Methods Manual - Polar volatile organic compounds in pulp industry wastewaters by microdistillation and GC-FID. Research Triangle Park, NC: National Council for Air and Stream Improvement, Inc. 2000 by the National Council for Air and Stream Improvement, Inc. Disclaimer: The mention of trade names or commercial products does not constitute endorsement or recommendation for use. The microdistillation step has been included in the Third Update of SW-846 as Method 5031. This method is included in the NCASI Methods Manual as a PROPOSED method. The purpose of including proposed methods in the NCASI Methods Manual is to make it known that a method is under development and to solicit comment regarding the technical merit and applicability of the method.
    [Show full text]
  • Toxicological Review of Tert-Butyl Alcohol (Tert-Butanol)
    EPA/635/R-16/079a Public Comment Draft www.epa.gov/iris Toxicological Review of tert-Butyl Alcohol (tert-Butanol) (CAS No. 75-65-0) April 2016 NOTICE This document is a Public Comment Draft. This information is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy. It is being circulated for review of its technical accuracy and science policy implications. National Center for Environmental Assessment Office of Research and Development U.S. Environmental Protection Agency Washington, DC Toxicological Review of tert-Butyl Alcohol DISCLAIMER This document is a preliminary draft for review purposes only. This information is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. This document is a draft for review purposes only and does not constitute Agency policy. ii DRAFT—DO NOT CITE OR QUOTE Toxicological Review of tert-Butyl Alcohol CONTENTS AUTHORS | CONTRIBUTORS | REVIEWERS ................................................................................................. viii PREFACE .......................................................................................................................................................
    [Show full text]
  • Alcohol to Jet - Isobutanol
    Alcohol to Jet - Isobutanol Glenn Johnston Vice President Regulatory Affairs Gevo Inc. Session 3 – Next in the Production Line: What to Expect for Future Development and Production of Aviation Alternative Fuels Biocatalyst Gevo integrated Isobutanol Alcohol (yeast) fermentation to Jet technology (ATJ) (GIFT®) Alcohol to Hydrocarbons • Sugar to Isobutanol fermentation facility owned by Gevo and producing renewable isobutanol. • Location – Luverne, MN • Creating the feedstock for our demonstration scale ATJ process in Silsbee, Texas • Proprietary processing based on standard unit operations in a typical petroleum refinery. • Gevo has been producing jet fuel since 2011 with over 5 years of process performance data on process capability and feedstock, including QA/QC process control charts to 6 SIGMA. • Process yields have been shown at 98% of theoretical. Process Flow Isobutanol Isobutylene C8-C16 olefins i-BuOH Isooctane Oligomerization Hydrogenation Dehydration Distillation separator 2 - phase Jet Water ASTM D7566 Annex 5 Standard Specification for Aviation Turbine Fuel Containing Synthesized Hydrocarbons A5. ALCOHOL-TO-JET SYNTHETIC PARAFFINIC KEROSENE (ATJ-SPK) ASTM D1655 Property Typical Jet A-1 Specification ATJ-SPK (Test Method) (CRC 647) (Jet A/Jet A-1) Freezing Point -40°C max Jet A - 50°C <-80°C (ASTM D2386) -47°C max Jet A-1 Flash Point 38°C min 48°C 48°C (ASTM D3828) Energy Density (Net Heat of Combustion) 42.8 MJ/kg min 42.9 MJ/kg 43.2 MJ/kg (ASTM D3338) Thermal Oxidation Stability (JFTOT) pass pass pass (ASTM D3241) Total Sulfur Content 0.3% max 0.05% <0.01% (ASTM D2622) • Extensive Quality Control Process of each lot which includes requirements from ASTM, Joint Inspection Group (JIG), DEFSTAN 91- 91 and others.
    [Show full text]
  • A Feasibility Study of Cellulosic Isobutanol Production—Process Simulation and Economic Analysis
    processes Article A Feasibility Study of Cellulosic Isobutanol Production—Process Simulation and Economic Analysis Avraam Roussos 1,*, Nikiforos Misailidis 1, Alexandros Koulouris 2, Francesco Zimbardi 3 and Demetri Petrides 4 1 Intelligen Europe, 57001 Thessaloniki, Greece; [email protected] 2 Alexander Technological Education Institute of Thessaloniki, 57400 Thessaloniki, Greece; [email protected] 3 Trisaia Research Centre, ENEA, 75026 Rotondella, Italy; [email protected] 4 Intelligen Inc., Scotch Plains, NJ 07076, USA; [email protected] * Correspondence: [email protected]; Tel.: +30-694-726-0939 Received: 21 June 2019; Accepted: 25 September 2019; Published: 27 September 2019 Abstract: Renewable liquid biofuels for transportation have recently attracted enormous global attention due to their potential to provide a sustainable alternative to fossil fuels. In recent years, the attention has shifted from first-generation bioethanol to the production of higher molecular weight alcohols, such as biobutanol, from cellulosic feedstocks. The economic feasibility of such processes depends on several parameters such as the cost of raw materials, the fermentation performance and the energy demand for the pretreatment of biomass and downstream processing. In this work, two conceptual process scenarios for isobutanol production, one with and one without integrated product removal from the fermentor by vacuum stripping, were developed and evaluated using SuperPro Designer®. In agreement with previous publications, it was concluded that the fermentation titer is a crucial parameter for the economic competitiveness of the process as it is closely related to the energy requirements for product purification. In the first scenario where the product titer was 22 g/L, the energy demand for downstream processing was 15.8 MJ/L isobutanol and the unit production cost of isobutanol was $2.24/L.
    [Show full text]
  • Safety Data Sheet
    SAFETY DATA SHEET Flammable Liquefied Gas Mixture: Ethanol / Isobutanol / Isopropanol (Isopropyl Alcohol) / Methanol / N-Butane / N-Butanol (N-Butyl Alcohol) / N-Propanol / Sec-Butyl Alcohol (2-Butanol) / Tert Butanol Section 1. Identification GHS product identifier : Flammable Liquefied Gas Mixture: Ethanol / Isobutanol / Isopropanol (Isopropyl Alcohol) / Methanol / N-Butane / N-Butanol (N-Butyl Alcohol) / N-Propanol / Sec-Butyl Alcohol (2-Butanol) / Tert Butanol Other means of : Not available. identification Product use : Synthetic/Analytical chemistry. SDS # : 011439 Supplier's details : Airgas USA, LLC and its affiliates 259 North Radnor-Chester Road Suite 100 Radnor, PA 19087-5283 1-610-687-5253 Emergency telephone : 1-866-734-3438 number (with hours of operation) Section 2. Hazards identification OSHA/HCS status : This material is considered hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200). Classification of the : FLAMMABLE GASES - Category 1 substance or mixture GASES UNDER PRESSURE - Liquefied gas GHS label elements Hazard pictograms : Signal word : Danger Hazard statements : Extremely flammable gas. Contains gas under pressure; may explode if heated. May cause frostbite. May form explosive mixtures in Air. May displace oxygen and cause rapid suffocation. Precautionary statements General : Read and follow all Safety Data Sheets (SDS’S) before use. Read label before use. Keep out of reach of children. If medical advice is needed, have product container or label at hand. Close valve after each use and when empty. Use equipment rated for cylinder pressure. Do not open valve until connected to equipment prepared for use. Use a back flow preventative device in the piping. Use only equipment of compatible materials of construction.
    [Show full text]
  • Isobutanol and Drinking Water (PDF)
    HEALTH RISK ASSESSMENT UNIT Isobutanol and Drinking Water Isobutanol is a contaminant that has been found in waters that could be used as drinking water sources in Minnesota. The Minnesota Department of Health (MDH) developed a health-based guidance value for isobutanol in drinking water and, based on this value and levels found in drinking water, does not expect isobutanol in drinking water will harm Minnesotans. Summary Isobutanol is used as a solvent and chemical manufacturing ingredient in several industries and may be used as a biofuel. The first commercial isobutanol biofuel site opened in Minnesota in 2012. Isobutanol has been found in stormwater runoff and groundwater in Minnesota. Isobutanol Isobutanol is used as a solvent in the flavor, fragrance, pharmaceutical, and pesticide industries and as a chemical manufacturing ingredient for products such as lacquer, paint strippers, paint primer, and craft paints. It is an approved food additive and is also naturally-occurring in some foods and many alcoholic beverages. Isobutanol may also be used as a biofuel because, like ethanol, it can be manufactured from corn and other plants. The first commercial bio-based isobutanol site in the United States opened in 2012 at a converted ethanol plant in southwestern Minnesota.1 A second plant was converted from ethanol to isobutanol production by 2015. Isobutanol in Minnesota Waters Isobutanol has been detected in stormwater runoff near an isobutanol production site in Minnesota at levels between 98 and 308 parts per billion (ppb). This runoff flows to a retaining pond which may be connected to local groundwater. Isobutanol has been detected in groundwater monitoring wells near landfills at levels between 74.5 and 105 ppb.2 MDH Guidance Value Based on available information, MDH developed a guidance value of 300 ppb for isobutanol in water.3 A person drinking water at or below the guidance value would have little or no risk of health effects.
    [Show full text]
  • Effect of Alcohols on Filamentation, Growth, Viability and Biofilm Development in Candida Albicans
    Brazilian Journal of Microbiology 44, 4, 1315-1320 (2013) Copyright © 2013, Sociedade Brasileira de Microbiologia ISSN 1678-4405 www.sbmicrobiologia.org.br Research Paper Effect of alcohols on filamentation, growth, viability and biofilm development in Candida albicans Nitin M Chauhan, Ravikumar B Shinde, S. Mohan Karuppayil DST-FIST and UGC-SAP Sponsored School of Life Sciences, SRTM University, Nanded, M.S, India. Submitted: August 2, 2012; Approved: April 4, 2013. Abstract In this study we report the potential of alcohols as morphogenetic regulators in Candida albicans. All the alcohols tested influenced various modes of growth like planktonic as well as biofilm forms. Via- bility was affected at high concentrations. Among the alcohols, the response of C. albicans to amyl alcohol (pentanol) was noteworthy. Amyl alcohol at a concentration 0.5% which was not inhibitory to growth and viability specifically inhibited morphogenetic switching from yeast to hyphal forms. It also inhibited normal biofilm development favoring yeast dominated biofilms. Based on this study we hypothesize that alcohols produced under anaerobic conditions may not favor biofilm develop- ment and support dissemination of yeast cells. Since anaerobic conditions are not found to favor pro- duction of quorum sensing molecules like farnesol, the alcohols may play a role in morphogenetic regulation. Key words: alcohols, signalling, morphogenesis, biofilms, yeast metabolism, Candida albicans. S. cerevisiae et al. Introduction mentation in (Lorenz , 2000). Attach- ment to tissue culture dishes and polystyrene dishes in Candida albicans is considered as a serious pathogen Pseudomonas species is affected by methanol, ethanol, in immunocompromised patients causing high mortality propanol, and butanol (Fletcher, 1983).
    [Show full text]
  • Toxicological Summary for Isobutanol (PDF)
    Health Based Guidance for Water Health Risk Assessment Unit, Environmental Health Division 651-201-4899 Web Publication Date: July 2016 Toxicological Summary for: Isobutanol CAS: 78-83-1 Synonyms: 2-Methyl-propan-1-ol (IUPAC); isobutyl alcohol; 2-methyl-1-propanol; 2- methylpropyl alcohol; IBA; 1-hydroxymethylpropane; isopropylcarbinol; 2- methylpropanol; 2-methylpropan-1-ol Acute Non-Cancer Health Based Value (nHBVAcute) = Not Derived (Insufficient Data) Short-term Non-Cancer Health Based Value (nHBVShort-term) = Not Derived (Insufficient Data) Subchronic Non-Cancer Health Based Value (nHBVSubchronic) = 700 µg/L (Reference Dose, mg/kg-d) x (Relative Source Contribution) x (Conversion Factor) (Subchronic Intake Rate, L/kg-d) = (0.24 mg/kg-d) x (0.2)* x (1000 µg/mg) (0.070 L/kg-d)** = 686 rounded to 700 µg/L *Relative Source Contribution: MDH 2008, Section IV.E.1. **Intake Rate: MDH 2008, Section IV.E.1. and US EPA 2011, Exposure Factors Handbook, Tables 3-1 and 3-81 Reference Dose/Concentration: HED/Total UF = 0.24 mg/kg-d (Wistar rats) Source of toxicity value: determined by MDH in 2014 Point of Departure (POD): 300 mg/kg-d (administered dose NOAEL, BASF 1992 and Schilling et al. 1997) Dose Adjustment Factor (DAF): Body weight scaling, default (US EPA 2011) Human Equivalent Dose (MDH, 2011): POD x DAF = 300 mg/kg-d x 0.24 = 72 mg/kg-d Total uncertainty factor (UF): 300 Uncertainty factor allocation: 3 for interspecies differences (for toxicodynamics), 10 for intraspecies variability, and 10 for database uncertainty (due to lack of oral
    [Show full text]
  • ISOBUTYL ALCOHOL CAS Number
    Common Name: ISOBUTYL ALCOHOL CAS Number: 78-83-1 RTK Substance number: 1043 DOT Number: UN 1212 Date: April 1997 Revision: April 2004 --------------------------------------------------------------------------- --------------------------------------------------------------------------- HAZARD SUMMARY * Isobutyl Alcohol can affect you when breathed in. * ODOR THRESHOLD = 3.6 ppm. * Isobutyl Alcohol can irritate the eyes and skin causing a * The range of accepted odor threshold values is quite rash or burning feeling on contact. broad. Caution should be used in relying on odor alone as * Breathing Isobutyl Alcohol can irritate the nose, mouth a warning of potentially hazardous exposures. and throat causing coughing and wheezing. * Exposure to Isobutyl Alcohol can cause headache, WORKPLACE EXPOSURE LIMITS dizziness, drowsiness, confusion and loss of coordination. OSHA: The legal airborne permissible exposure limit * Isobutyl Alcohol may affect the liver. (PEL) is 100 ppm averaged over an 8-hour * Isobutyl Alcohol is a FLAMMABLE LIQUID and a workshift. DANGEROUS FIRE HAZARD. NIOSH: The recommended airborne exposure limit is IDENTIFICATION 50 ppm averaged over a 10-hour workshift. Isobutyl Alcohol is a colorless liquid with a mild, sweet, and musty odor. It is used as a solvent, in making other chemicals, ACGIH: The recommended airborne exposure limit is and as a flavoring. 50 ppm averaged over an 8-hour workshift. REASON FOR CITATION WAYS OF REDUCING EXPOSURE * Isobutyl Alcohol is on the Hazardous Substance List * Where possible, enclose operations and use local exhaust because it is regulated by OSHA and cited by ACGIH, ventilation at the site of chemical release. If local exhaust DOT, NIOSH, IRIS, NFPA and EPA. ventilation or enclosure is not used, respirators should be * This chemical is on the Special Health Hazard Substance worn.
    [Show full text]
  • Toxicological Review of Tert-Butyl Alcohol (Tert-Butanol)
    DRAFT DELIBERATIVE: FOR INTERAGENCY REVIEW ONLY. DO NOT DISTRIBUTE OUTSIDE YOUR AGENCY. EPA/635/R-14/378 Interagency Review Draft www.epa.gov/iris Toxicological Review of tert-Butyl Alcohol (tert-Butanol) (CAS No. 75-65-0) In Support of Summary Information on the Integrated Risk Information System (IRIS) September 2014 This document is an Interagency Science Consultation Review draft. This information is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy. It is being circulated for review of its technical accuracy and science policy implications. National Center for Environmental Assessment Office of Research and Development U.S. Environmental Protection Agency Washington, DC Toxicological Review of tert-Butyl Alcohol DISCLAIMER This document is a preliminary draft for review purposes only. This information is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. This document is a draft for review purposes only and does not constitute Agency policy. ii DRAFT—DO NOT CITE OR QUOTE Toxicological Review of tert-Butyl Alcohol
    [Show full text]