DOCSLIB.ORG

ISOBUTYL ALCOHOL CAS Number

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
ISOBUTYL ALCOHOL CAS Number Common Name: ISOBUTYL ALCOHOL CAS Number: 78-83-1 RTK Substance number: 1043 DOT Number: UN 1212 Date: April 1997 Revision: April 2004 --------------------------------------------------------------------------- --------------------------------------------------------------------------- HAZARD SUMMARY * Isobutyl Alcohol can affect you when breathed in. * ODOR THRESHOLD = 3.6 ppm. * Isobutyl Alcohol can irritate the eyes and skin causing a * The range of accepted odor threshold values is quite rash or burning feeling on contact. broad. Caution should be used in relying on odor alone as * Breathing Isobutyl Alcohol can irritate the nose, mouth a warning of potentially hazardous exposures. and throat causing coughing and wheezing. * Exposure to Isobutyl Alcohol can cause headache, WORKPLACE EXPOSURE LIMITS dizziness, drowsiness, confusion and loss of coordination. OSHA: The legal airborne permissible exposure limit * Isobutyl Alcohol may affect the liver. (PEL) is 100 ppm averaged over an 8-hour * Isobutyl Alcohol is a FLAMMABLE LIQUID and a workshift. DANGEROUS FIRE HAZARD. NIOSH: The recommended airborne exposure limit is IDENTIFICATION 50 ppm averaged over a 10-hour workshift. Isobutyl Alcohol is a colorless liquid with a mild, sweet, and musty odor. It is used as a solvent, in making other chemicals, ACGIH: The recommended airborne exposure limit is and as a flavoring. 50 ppm averaged over an 8-hour workshift. REASON FOR CITATION WAYS OF REDUCING EXPOSURE * Isobutyl Alcohol is on the Hazardous Substance List * Where possible, enclose operations and use local exhaust because it is regulated by OSHA and cited by ACGIH, ventilation at the site of chemical release. If local exhaust DOT, NIOSH, IRIS, NFPA and EPA. ventilation or enclosure is not used, respirators should be * This chemical is on the Special Health Hazard Substance worn. List because it is FLAMMABLE. * Wear protective work clothing. * Definitions are provided on page 5. * Wash thoroughly immediately after exposure to Isobutyl Alcohol and at the end of the workshift. HOW TO DETERMINE IF YOU ARE BEING * Post hazard and warning information in the work area. In EXPOSED addition, as part of an ongoing education and training effort, communicate all information on the health and The New Jersey Right to Know Act requires most employers safety hazards of Isobutyl Alcohol to potentially exposed to label chemicals in the workplace and requires public workers. employers to provide their employees with information and training concerning chemical hazards and controls. The federal OSHA Hazard Communication Standard, 1910.1200, requires private employers to provide similar training and information to their employees. * Exposure to hazardous substances should be routinely evaluated. This may include collecting personal and area air samples. You can obtain copies of sampling results from your employer. You have a legal right to this information under OSHA 1910.1020. * If you think you are experiencing any work-related health problems, see a doctor trained to recognize occupational diseases. Take this Fact Sheet with you. ISOBUTYL ALCOHOL page 2 of 6 This Fact Sheet is a summary source of information of all * Evaluate for brain effects such as changes in memory, potential and most severe health hazards that may result from concentration, sleeping patterns and mood (especially exposure. Duration of exposure, concentration of the substance irritability and social withdrawal), as well as headaches and and other factors will affect your susceptibility to any of the fatigue. Consider evaluations of the cerebellar, autonomic potential effects described below. and peripheral nervous systems. Positive and borderline --------------------------------------------------------------------------- individuals should be referred for neuropsychological testing. HEALTH HAZARD INFORMATION Any evaluation should include a careful history of past and Acute Health Effects present symptoms with an exam. Medical tests that look for The following acute (short-term) health effects may occur damage already done are not a substitute for controlling immediately or shortly after exposure to Isobutyl Alcohol: exposure. * Isobutyl Alcohol can irritate the eyes and skin causing a Request copies of your medical testing. You have a legal right rash or burning feeling on contact. to this information under OSHA 1910.1020. * Breathing Isobutyl Alcohol can irritate the nose, mouth and throat causing coughing and wheezing. Mixed Exposures * Exposure to Isobutyl Alcohol can cause headache, * Because more than light alcohol consumption can cause dizziness, drowsiness, confusion and loss of coordination. liver damage, drinking alcohol may increase the liver damage caused by Isobutyl Alcohol. Chronic Health Effects The following chronic (long-term) health effects can occur at WORKPLACE CONTROLS AND PRACTICES some time after exposure to Isobutyl Alcohol and can last for months or years: Unless a less toxic chemical can be substituted for a hazardous substance, ENGINEERING CONTROLS are the most Cancer Hazard effective way of reducing exposure. The best protection is to * There is limited evidence that Isobutyl Alcohol causes enclose operations and/or provide local exhaust ventilation at cancer in animals. It may cause cancer of the stomach and the site of chemical release. Isolating operations can also liver. reduce exposure. Using respirators or protective equipment is * Many scientists believe there is no safe level of exposure to less effective than the controls mentioned above, but is a carcinogen. Such substances may also have the potential sometimes necessary. for causing reproductive damage in humans. In evaluating the controls present in your workplace, consider: Reproductive Hazard (1) how hazardous the substance is, (2) how much of the * According to the information presently available to the New substance is released into the workplace and (3) whether Jersey Department of Health and Senior Services, Isobutyl harmful skin or eye contact could occur. Special controls Alcohol has not been tested for its ability to affect should be in place for highly toxic chemicals or when reproduction. significant skin, eye, or breathing exposures are possible. Other Long-Term Effects In addition, the following controls are recommended: * Isobutyl Alcohol may affect the liver. * This chemical has not been adequately evaluated to * Where possible, automatically pump liquid Isobutyl determine whether brain or other nerve damage could occur Alcohol from drums or other storage containers to process with repeated exposure. However, many solvents and other containers. petroleum-based chemicals have been shown to cause such * Before entering a confined space where Isobutyl Alcohol damage. Effects may include reduced memory and may be present, check to make sure that an explosive concentration, personality changes (withdrawal, irritability), concentration does not exist. fatigue, sleep disturbances, reduced coordination, and/or effects on nerves supplying internal organs (autonomic Good WORK PRACTICES can help to reduce hazardous nerves) and/or nerves to the arms and legs (weakness, "pins exposures. The following work practices are recommended: and needles"). * Workers whose clothing has been contaminated by MEDICAL Isobutyl Alcohol should change into clean clothing promptly. Medical Testing * Contaminated work clothes should be laundered by If symptoms develop or overexposure is suspected, the individuals who have been informed of the hazards of following are recommended: exposure to Isobutyl Alcohol. * Eye wash fountains should be provided in the immediate * Liver function tests. work area for emergency use. ISOBUTYL ALCOHOL page 3 of 6 * If there is the possibility of skin exposure, emergency * If while wearing a filter or cartridge respirator you can shower facilities should be provided. smell, taste, or otherwise detect Isobutyl Alcohol, or if * On skin contact with Isobutyl Alcohol, immediately wash while wearing particulate filters abnormal resistance to or shower to remove the chemical. At the end of the breathing is experienced, or eye irritation occurs while workshift, wash any areas of the body that may have wearing a full facepiece respirator, leave the area contacted Isobutyl Alcohol, whether or not known skin immediately. Check to make sure the respirator-to-face seal contact has occurred. is still good. If it is, replace the filter or cartridge. If the * Do not eat, smoke, or drink where Isobutyl Alcohol is seal is no longer good, you may need a new respirator. handled, processed, or stored, since the chemical can be * Be sure to consider all potential exposures in your swallowed. Wash hands carefully before eating, drinking, workplace. You may need a combination of filters, smoking, or using the toilet. prefilters or cartridges to protect against different forms of a chemical (such as vapor and mist) or against a mixture of PERSONAL PROTECTIVE EQUIPMENT chemicals. * Where the potential for high exposure exists, use a WORKPLACE CONTROLS ARE BETTER THAN MSHA/NIOSH approved supplied-air respirator with a full PERSONAL PROTECTIVE EQUIPMENT. However, for facepiece operated in a pressure-demand or other positive- some jobs (such as outside work, confined space entry, jobs pressure mode. For increased protection use in combination done only once in a while, or jobs done while workplace with an auxiliary self-contained breathing apparatus controls are being installed), personal protective equipment operated in a pressure-demand
Load more

Recommended publications
  • Isobutanol in Marine Gasoline
    Isobutanol in Marine Gasoline Glenn Johnston July 11, 2017 Bioeconomy 2017 Washington D.C. 1B: Drivers for Emergence of Biofuels for Maritime Industry © 2012 Gevo, Inc. | 1 Gevo’s Current Business System Gevo Production Facilities Core Near Term Markets Isobutanol Production – Side-by-Side with Ethanol Drop-in Markets - Isobutanol Luverne, MN Isobutanol Specialty Chemicals & Solvents Specialty Gasoline Blendstock (Marine/Off-Road) 15 MGPY EtOH 1.5 MGPY IBA* Isobutanol Hydrocarbon Biorefinery Drop-in Markets - Hydrocarbons South Hydrocarbons Hampton Jet Fuel Resources Silsbee, TX Isooctane (gasoline) © 2016 Gevo, Inc. | 2 Isobutanol Properties Gasoline blending value Gasoline Ethanol Isobutanol RON 95 109 105 MON 85 90 91 Anti-knock Index 90 100 98 RVP (psi) 7-15 19 5.2 Density 20C [kg/m3] 720-775 794 801 Boiling Point (C) 32.2 21.1 26.6 % Heating Value of Gasoline 100 66 84 Oxygen (%w/w) <2.7% 34.7 21.6 isobutanol has low RVP, enabling refiners to blend incremental volumes of butanes and pentanes Marine Research Overview Marine Engine Tested – BRP Envinrude and SeaDoo, Mercury, Volvo-Penta, Yamaha, Tohatsu, Indmar, OMC-Johnson, Honda. Marine Biobutanol over 5 years of research -Alternative Fuel Butanol: Preliminary Investigation on Performance and Emissions of a Marine Two-Stroke Direct Fuel Injection Engine -Impact of Blending Gasoline with lsobutanol Compared to Ethanol on Efficiency, Performance and Emissions of a Recreational Marine 4-Stroke Engine -Gaseous and Particulate Emissions Using Isobutanol-Extended Fuel in Recreational Marine
    [Show full text]
  • Next Generation Biofuels
    Photo-Synthetic Biology for Fuels James C. Liao Chemical and Biomolecular Engineering University of California, Los Angeles The Current Biofuel Cycle CO2 CO2 Ethanol Biodiesel The Direct Solar Fuel Cycle CO2 CO2 Higher Alcohols Biofuels Long chain Ethanol alcohols/alkanes Energy content Low High Hygroscopicity High Low Vehicle Yes No retrofitting? Vapor pressure High Low Production High Zero/Low yield Higher alcohols Native producers? yes Iso-propanol no n-propanol yes n-butanol no Iso-butanol no 2-methyl-1-butanol no 3-methyl-1-butanol Pathways for alcohol synthesis CoA-dependent pathway Pyruvate PDH NADH Acetyl-CoA Acetaldehyde NADH NADH ADH Acetoacetyl-CoA Ethanol 3-Hydroxybutyryl-CoA Crotonyl-CoA Butyryl-CoA Butyraldehyde n-Butanol Alternative Pathways to Make Alcohols CoA-dependent pathway Pyruvate Non-CoA pathway PDH NADH PDC Acetyl-CoA Acetaldehyde NADH NADH ADH ? Acetoacetyl-CoA Ethanol 3-Hydroxybutyryl-CoA Crotonyl-CoA Butyryl-CoA Butyraldehyde n-Butanol Atsumi et al. Nature 2008 Generalization of keto acid decarboxylase chemistry Longer chain keto acids A simple keto acid Pyruvate 2-keto acid PDC KDC Acetylaldehyde R-aldehyde ADH ADH Ethanol R-OH Ehrlich, F. Ber. Dtsch. Chem. Ges.1907 Opening the active site Zymomonas mobilis PDC Lactococcus lactis KdcA E.coli Long Chain 2-keto acids KDC 2-keto acids) R-aldehyde ADH 2008 2-phenylethanol (from Nature 3-M-1-butanol et al. 2-M-1-butanol p henylpyruvate Atsumi Production of Higher Alcohols1-butanol in 2-keto-4-methyl-pentanoate 2-keto-3-methyl-valerate isobutanol 2-ketovalerate 1-propanol 2-ketoisovalerate Production (mM) Production 2-ketobutyrate ํC 40hr 30 Further generalization of alcohol‐ producing chemistry Atsumi et al.
    [Show full text]
  • Method MD-99 Polar Volatile Organic Compounds in Pulp Industry Wastewaters by Microdistillation and GC-FID
    NCASI METHOD MD-99 POLAR VOLATILE ORGANIC COMPOUNDS IN PULP INDUSTRY WASTEWATERS BY MICRODISTILLATION AND GC-FID NCASI West Coast Regional Center Organic Analytical Program July 1999 Acknowledgments This method is authored by Alex Gholson, Senior Research Scientist, and Dean Hoy, Research Associate, with assistance from Diana Cook, Senior Research Scientist, all of NCASI West Coast Regional Center. Mark Bruce of Wadsworth Alert Labs (now Quanterra) developed the microdistillation technique and also provided valuable input during development of this method. For more information about this method, contact: Alex Gholson, Ph.D. John Pinkerton, Ph.D. Senior Research Scientist Vice President, Air Quality NCASI West Coast Regional Center NCASI P.O. Box 458 P.O. Box 13318 Corvallis, OR 97339 Research Triangle Park, NC 27709 (541) 752-8801 (919) 558-1992 [email protected] [email protected] For information about NCASI publications, contact: Publications Coordinator NCASI PO Box 13318 Research Triangle Park, NC 27709 (919) 558-1999 [email protected] National Council for Air and Stream Improvement, Inc. (NCASI). 2000. Methods Manual - Polar volatile organic compounds in pulp industry wastewaters by microdistillation and GC-FID. Research Triangle Park, NC: National Council for Air and Stream Improvement, Inc. 2000 by the National Council for Air and Stream Improvement, Inc. Disclaimer: The mention of trade names or commercial products does not constitute endorsement or recommendation for use. The microdistillation step has been included in the Third Update of SW-846 as Method 5031. This method is included in the NCASI Methods Manual as a PROPOSED method. The purpose of including proposed methods in the NCASI Methods Manual is to make it known that a method is under development and to solicit comment regarding the technical merit and applicability of the method.
    [Show full text]
  • Toxicological Review of Tert-Butyl Alcohol (Tert-Butanol)
    EPA/635/R-16/079a Public Comment Draft www.epa.gov/iris Toxicological Review of tert-Butyl Alcohol (tert-Butanol) (CAS No. 75-65-0) April 2016 NOTICE This document is a Public Comment Draft. This information is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy. It is being circulated for review of its technical accuracy and science policy implications. National Center for Environmental Assessment Office of Research and Development U.S. Environmental Protection Agency Washington, DC Toxicological Review of tert-Butyl Alcohol DISCLAIMER This document is a preliminary draft for review purposes only. This information is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. This document is a draft for review purposes only and does not constitute Agency policy. ii DRAFT—DO NOT CITE OR QUOTE Toxicological Review of tert-Butyl Alcohol CONTENTS AUTHORS | CONTRIBUTORS | REVIEWERS ................................................................................................. viii PREFACE .......................................................................................................................................................
    [Show full text]
  • Alcohol to Jet - Isobutanol
    Alcohol to Jet - Isobutanol Glenn Johnston Vice President Regulatory Affairs Gevo Inc. Session 3 – Next in the Production Line: What to Expect for Future Development and Production of Aviation Alternative Fuels Biocatalyst Gevo integrated Isobutanol Alcohol (yeast) fermentation to Jet technology (ATJ) (GIFT®) Alcohol to Hydrocarbons • Sugar to Isobutanol fermentation facility owned by Gevo and producing renewable isobutanol. • Location – Luverne, MN • Creating the feedstock for our demonstration scale ATJ process in Silsbee, Texas • Proprietary processing based on standard unit operations in a typical petroleum refinery. • Gevo has been producing jet fuel since 2011 with over 5 years of process performance data on process capability and feedstock, including QA/QC process control charts to 6 SIGMA. • Process yields have been shown at 98% of theoretical. Process Flow Isobutanol Isobutylene C8-C16 olefins i-BuOH Isooctane Oligomerization Hydrogenation Dehydration Distillation separator 2 - phase Jet Water ASTM D7566 Annex 5 Standard Specification for Aviation Turbine Fuel Containing Synthesized Hydrocarbons A5. ALCOHOL-TO-JET SYNTHETIC PARAFFINIC KEROSENE (ATJ-SPK) ASTM D1655 Property Typical Jet A-1 Specification ATJ-SPK (Test Method) (CRC 647) (Jet A/Jet A-1) Freezing Point -40°C max Jet A - 50°C <-80°C (ASTM D2386) -47°C max Jet A-1 Flash Point 38°C min 48°C 48°C (ASTM D3828) Energy Density (Net Heat of Combustion) 42.8 MJ/kg min 42.9 MJ/kg 43.2 MJ/kg (ASTM D3338) Thermal Oxidation Stability (JFTOT) pass pass pass (ASTM D3241) Total Sulfur Content 0.3% max 0.05% <0.01% (ASTM D2622) • Extensive Quality Control Process of each lot which includes requirements from ASTM, Joint Inspection Group (JIG), DEFSTAN 91- 91 and others.
    [Show full text]
  • A Feasibility Study of Cellulosic Isobutanol Production—Process Simulation and Economic Analysis
    processes Article A Feasibility Study of Cellulosic Isobutanol Production—Process Simulation and Economic Analysis Avraam Roussos 1,*, Nikiforos Misailidis 1, Alexandros Koulouris 2, Francesco Zimbardi 3 and Demetri Petrides 4 1 Intelligen Europe, 57001 Thessaloniki, Greece; [email protected] 2 Alexander Technological Education Institute of Thessaloniki, 57400 Thessaloniki, Greece; [email protected] 3 Trisaia Research Centre, ENEA, 75026 Rotondella, Italy; [email protected] 4 Intelligen Inc., Scotch Plains, NJ 07076, USA; [email protected] * Correspondence: [email protected]; Tel.: +30-694-726-0939 Received: 21 June 2019; Accepted: 25 September 2019; Published: 27 September 2019 Abstract: Renewable liquid biofuels for transportation have recently attracted enormous global attention due to their potential to provide a sustainable alternative to fossil fuels. In recent years, the attention has shifted from first-generation bioethanol to the production of higher molecular weight alcohols, such as biobutanol, from cellulosic feedstocks. The economic feasibility of such processes depends on several parameters such as the cost of raw materials, the fermentation performance and the energy demand for the pretreatment of biomass and downstream processing. In this work, two conceptual process scenarios for isobutanol production, one with and one without integrated product removal from the fermentor by vacuum stripping, were developed and evaluated using SuperPro Designer®. In agreement with previous publications, it was concluded that the fermentation titer is a crucial parameter for the economic competitiveness of the process as it is closely related to the energy requirements for product purification. In the first scenario where the product titer was 22 g/L, the energy demand for downstream processing was 15.8 MJ/L isobutanol and the unit production cost of isobutanol was $2.24/L.
    [Show full text]
  • Safety Data Sheet
    SAFETY DATA SHEET Flammable Liquefied Gas Mixture: Ethanol / Isobutanol / Isopropanol (Isopropyl Alcohol) / Methanol / N-Butane / N-Butanol (N-Butyl Alcohol) / N-Propanol / Sec-Butyl Alcohol (2-Butanol) / Tert Butanol Section 1. Identification GHS product identifier : Flammable Liquefied Gas Mixture: Ethanol / Isobutanol / Isopropanol (Isopropyl Alcohol) / Methanol / N-Butane / N-Butanol (N-Butyl Alcohol) / N-Propanol / Sec-Butyl Alcohol (2-Butanol) / Tert Butanol Other means of : Not available. identification Product use : Synthetic/Analytical chemistry. SDS # : 011439 Supplier's details : Airgas USA, LLC and its affiliates 259 North Radnor-Chester Road Suite 100 Radnor, PA 19087-5283 1-610-687-5253 Emergency telephone : 1-866-734-3438 number (with hours of operation) Section 2. Hazards identification OSHA/HCS status : This material is considered hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200). Classification of the : FLAMMABLE GASES - Category 1 substance or mixture GASES UNDER PRESSURE - Liquefied gas GHS label elements Hazard pictograms : Signal word : Danger Hazard statements : Extremely flammable gas. Contains gas under pressure; may explode if heated. May cause frostbite. May form explosive mixtures in Air. May displace oxygen and cause rapid suffocation. Precautionary statements General : Read and follow all Safety Data Sheets (SDS’S) before use. Read label before use. Keep out of reach of children. If medical advice is needed, have product container or label at hand. Close valve after each use and when empty. Use equipment rated for cylinder pressure. Do not open valve until connected to equipment prepared for use. Use a back flow preventative device in the piping. Use only equipment of compatible materials of construction.
    [Show full text]
  • Isobutanol and Drinking Water (PDF)
    HEALTH RISK ASSESSMENT UNIT Isobutanol and Drinking Water Isobutanol is a contaminant that has been found in waters that could be used as drinking water sources in Minnesota. The Minnesota Department of Health (MDH) developed a health-based guidance value for isobutanol in drinking water and, based on this value and levels found in drinking water, does not expect isobutanol in drinking water will harm Minnesotans. Summary Isobutanol is used as a solvent and chemical manufacturing ingredient in several industries and may be used as a biofuel. The first commercial isobutanol biofuel site opened in Minnesota in 2012. Isobutanol has been found in stormwater runoff and groundwater in Minnesota. Isobutanol Isobutanol is used as a solvent in the flavor, fragrance, pharmaceutical, and pesticide industries and as a chemical manufacturing ingredient for products such as lacquer, paint strippers, paint primer, and craft paints. It is an approved food additive and is also naturally-occurring in some foods and many alcoholic beverages. Isobutanol may also be used as a biofuel because, like ethanol, it can be manufactured from corn and other plants. The first commercial bio-based isobutanol site in the United States opened in 2012 at a converted ethanol plant in southwestern Minnesota.1 A second plant was converted from ethanol to isobutanol production by 2015. Isobutanol in Minnesota Waters Isobutanol has been detected in stormwater runoff near an isobutanol production site in Minnesota at levels between 98 and 308 parts per billion (ppb). This runoff flows to a retaining pond which may be connected to local groundwater. Isobutanol has been detected in groundwater monitoring wells near landfills at levels between 74.5 and 105 ppb.2 MDH Guidance Value Based on available information, MDH developed a guidance value of 300 ppb for isobutanol in water.3 A person drinking water at or below the guidance value would have little or no risk of health effects.
    [Show full text]
  • Effect of Alcohols on Filamentation, Growth, Viability and Biofilm Development in Candida Albicans
    Brazilian Journal of Microbiology 44, 4, 1315-1320 (2013) Copyright © 2013, Sociedade Brasileira de Microbiologia ISSN 1678-4405 www.sbmicrobiologia.org.br Research Paper Effect of alcohols on filamentation, growth, viability and biofilm development in Candida albicans Nitin M Chauhan, Ravikumar B Shinde, S. Mohan Karuppayil DST-FIST and UGC-SAP Sponsored School of Life Sciences, SRTM University, Nanded, M.S, India. Submitted: August 2, 2012; Approved: April 4, 2013. Abstract In this study we report the potential of alcohols as morphogenetic regulators in Candida albicans. All the alcohols tested influenced various modes of growth like planktonic as well as biofilm forms. Via- bility was affected at high concentrations. Among the alcohols, the response of C. albicans to amyl alcohol (pentanol) was noteworthy. Amyl alcohol at a concentration 0.5% which was not inhibitory to growth and viability specifically inhibited morphogenetic switching from yeast to hyphal forms. It also inhibited normal biofilm development favoring yeast dominated biofilms. Based on this study we hypothesize that alcohols produced under anaerobic conditions may not favor biofilm develop- ment and support dissemination of yeast cells. Since anaerobic conditions are not found to favor pro- duction of quorum sensing molecules like farnesol, the alcohols may play a role in morphogenetic regulation. Key words: alcohols, signalling, morphogenesis, biofilms, yeast metabolism, Candida albicans. S. cerevisiae et al. Introduction mentation in (Lorenz , 2000). Attach- ment to tissue culture dishes and polystyrene dishes in Candida albicans is considered as a serious pathogen Pseudomonas species is affected by methanol, ethanol, in immunocompromised patients causing high mortality propanol, and butanol (Fletcher, 1983).
    [Show full text]
  • Toxicological Summary for Isobutanol (PDF)
    Health Based Guidance for Water Health Risk Assessment Unit, Environmental Health Division 651-201-4899 Web Publication Date: July 2016 Toxicological Summary for: Isobutanol CAS: 78-83-1 Synonyms: 2-Methyl-propan-1-ol (IUPAC); isobutyl alcohol; 2-methyl-1-propanol; 2- methylpropyl alcohol; IBA; 1-hydroxymethylpropane; isopropylcarbinol; 2- methylpropanol; 2-methylpropan-1-ol Acute Non-Cancer Health Based Value (nHBVAcute) = Not Derived (Insufficient Data) Short-term Non-Cancer Health Based Value (nHBVShort-term) = Not Derived (Insufficient Data) Subchronic Non-Cancer Health Based Value (nHBVSubchronic) = 700 µg/L (Reference Dose, mg/kg-d) x (Relative Source Contribution) x (Conversion Factor) (Subchronic Intake Rate, L/kg-d) = (0.24 mg/kg-d) x (0.2)* x (1000 µg/mg) (0.070 L/kg-d)** = 686 rounded to 700 µg/L *Relative Source Contribution: MDH 2008, Section IV.E.1. **Intake Rate: MDH 2008, Section IV.E.1. and US EPA 2011, Exposure Factors Handbook, Tables 3-1 and 3-81 Reference Dose/Concentration: HED/Total UF = 0.24 mg/kg-d (Wistar rats) Source of toxicity value: determined by MDH in 2014 Point of Departure (POD): 300 mg/kg-d (administered dose NOAEL, BASF 1992 and Schilling et al. 1997) Dose Adjustment Factor (DAF): Body weight scaling, default (US EPA 2011) Human Equivalent Dose (MDH, 2011): POD x DAF = 300 mg/kg-d x 0.24 = 72 mg/kg-d Total uncertainty factor (UF): 300 Uncertainty factor allocation: 3 for interspecies differences (for toxicodynamics), 10 for intraspecies variability, and 10 for database uncertainty (due to lack of oral
    [Show full text]
  • Toxicological Review of Tert-Butyl Alcohol (Tert-Butanol)
    DRAFT DELIBERATIVE: FOR INTERAGENCY REVIEW ONLY. DO NOT DISTRIBUTE OUTSIDE YOUR AGENCY. EPA/635/R-14/378 Interagency Review Draft www.epa.gov/iris Toxicological Review of tert-Butyl Alcohol (tert-Butanol) (CAS No. 75-65-0) In Support of Summary Information on the Integrated Risk Information System (IRIS) September 2014 This document is an Interagency Science Consultation Review draft. This information is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy. It is being circulated for review of its technical accuracy and science policy implications. National Center for Environmental Assessment Office of Research and Development U.S. Environmental Protection Agency Washington, DC Toxicological Review of tert-Butyl Alcohol DISCLAIMER This document is a preliminary draft for review purposes only. This information is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. This document is a draft for review purposes only and does not constitute Agency policy. ii DRAFT—DO NOT CITE OR QUOTE Toxicological Review of tert-Butyl Alcohol
    [Show full text]
  • Health and Environmental Effects Profile for Isobutanol
    EPA/600/X-86/149 May 1986 PB89-12.3376 HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ISOBUTANOL ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT OFFICE OF RESEARCH AND DEVELOPMENT U.S. ENVIRONMENTAL PROTECTION AGENCY CINCINNATI, OH 45268 \ DISCLAIMER This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. i i PREFACE Health and Environmental Effects Profiles (HEEPs} are prepared for the Office of Solid Waste by the Office of Health and Environmental Assessment. The HEEPs are intended to support listings of hazardous constituents of a wide range of waste streams under Section 3001 of the Resource Conservation and Recovery Act (RCRA). Both published literature and information obtained from Agency program office files are evaluated as they pertain to potential human health, aquatic life and environmental effects of hazardous waste constit­ uents. The literature searched and the dates of the searches are included in the section titled "Appendix: Literature Searched." Quantitative estimates are presented provided sufficient data are available. For systemic toxicants, these include, Acceptable Daily Intakes (ADis} for chronic exposures. An ADI is defined as the amount of a chemical to which humans can be exposed on a daily basis over an extended period of time (usually a lifetime} without suffering a deleterious effect. In the case of suspected ca-rcinogens, ADis are not estimated in this document series. Instead, a carcinogenic potency factor or ql* is provided. These potency estimates are derived for both oral and inhalation exposures where pos·sible.
    [Show full text]