Patrick Miller

Total Page:16

File Type:pdf, Size:1020Kb

Patrick Miller [email protected] Patrick Miller Education University of Notre Dame Ph.D. Quantitative Psychology (2017) Advisor: Dr. Gitta Lubke NSF Graduate Research Fellowship 2013-2016 Presidential Fellowship, University of Notre Dame 2012 - 2017 Dean's Fellowship, University of Notre Dame 2012 - 2017 University of Notre Dame M.S. Applied Computational & Mathematical Statistics 2015 Advisor: Dr. Fang Liu University of Kansas B.S. Cognitive Psychology with distinction, Honors in Psychology 2012 Minor: Social and Behavioral Sciences Methodology Honors Thesis: \Developing simsem: Simplifying Monte Carlo Simulation with Missing Data" Advisor: Dr. Todd Little Publications Miller P.J., Lubke G.H, McArtor D.B., Bergeman C.S. (Submitted) Finding structure in data using multivariate tree boosting. Psychological Methods. Lubke, G. H., Miller, P. J., Verhulst, B., Bartels, M., Van Beijsterveldt, T., Willemsen, G., , & Middeldorp, C. M. (2015). A powerful phenotype for gene-finding studies derived from trajectory analyses of symptoms of anxiety and depression between age 7 and 18 American Journal of Medical Genetics: Neuropsychiatric Genetics Part B. Lubke, G. H., & Miller, P. J. (2014). Does nature have joints worth carving? A discussion of taxometrics, model-based clustering and latent variable mixture modeling. Psychological medicine, 1-11. Schoemann, A. M., Miller, P. J., Pornprasertmanit, S., & Wu, W. (2014). Using Monte Carlo simulations to determine power and sample size in planned missing data designs. International Journal of Behavioral Development, 38, 471-479. Software Miller, P.J. (2016). Multivariate tree boosting. [R package]. https://github.com/patr1ckm/ mvtboost Pornprasertmanit, S., Miller, P.J., Schoemann, A.M., simsem: Simulated structural equation mod- eling. [R package] http://simsem.org Presentations Miller, P.J. (2015, September) Association of aggression with metabolites in adults. Presentation, ACTION: Beyond the Genetics of Aggression, Amsterdam, the Netherlands. Miller, P.J., Lubke, G.H., Verhulst, B., Bartels, M., van Beijsterveldt T., Willemnsen, G., Bommsma, D.I., Middeldorp C.M (2015, June) A powerful depression phenotype: Trajectories of anxiety and depression between age 7 and age 18 and the role of genetic factors. Presentation, Behavior Genetics Association, San Diego, USA. Miller, P.J, McArtor D., Lubke, G.H. (2015, February) Multivariate approaches for understanding the genetics of psychiatric disorders. Poster, Psychology Department Research Overview, University of Notre Dame. Miller, P.J. (2014, October) A flexible method for selecting predictors that influence multiple outcome variables. Talk, Quantitative Studies Group, University of Notre Dame Miller, P.J. (2014, March) Internalizing Problem Trajectories and Transitions. Talk, Quantitative Studies Group, University of Notre Dame. Middeldorp, C.M., Miller, P.J., Nivard, M.G., Munafo, M. R., Evans, D. M., Beate S. P., Davies, G., Scheet, P., Hottenga, J., Boomsma, D.I., Lubke, G.H. (2013, October) The use of longitudinal data of childhood and adolescent internalizing problems in genetic studies. Poster, World Congress of Psychiatric Genetics, Boston, USA. Miller, P.J. (2013, October) Investigating Heterogeneity in Trajectories of Internalizing Problems in Children and Adolescents. Talk, Quantitative Studies Group, University of Notre Dame. Miller, P.J. (2013, August) Evaluation of a Multivariate Boosting Algorithm for Genome-Wide As- sociation Studies. Talk, Department of Psychology First Year Project Presentations, University of Notre Dame. Miller, P.J., McArtor, D. (2013-2015 July) Finding genes associated with complex diseases and traits with high performance computing. Talk, Pre-College Program in Research Computing, University of Notre Dame Miller, P.J. (2013, May) Boosting with Multivariate Outcomes. Talk, Quantitative Studies Group, University of Notre Dame Miller, P.J. (2012, November) A Statistical Learning Method for Multivariate Psychological Out- comes. Talk, Quantitative Studies Group, University of Notre Dame Miller, P. J., Pornprasertmanit, S., Schoemann A.M., Little, T.D. (2012) Developing simsem: Sim- plifying Monte Carlo Simulation with Missing Data. Talk, Undergraduate Research Symposium, University of Kansas Miller, P.J., Pornprasertmanit, S., Schoemann A.M., Little, T.D. (2012) Developing simsem: Simpli- fying Monte Carlo Simulation with Missing Data. Poster, Symposium for Undergraduate Psychology Research, University of Kansas Little, T. D., Schoemann, A. M., Pornprasertmanit, S., Miller, P. (October, 2012). simsem: SIM- ulated Structural Equation Modeling in R. Paper presented at the Tenth Annual Society of Multi- variate Experimental Psychology, Vancouver, Canada. Schoemann, A. M., Pornprasertmanit, S., Miller, P. (July, 2012). simsem: SIMulated Structural Equation Modeling in R. Presentation at the International Meeting of the Psychometric Society, Lincoln, NE. Miller, P., Gill, A. (2011) An R Interface for Reconfigurable Computing. Talk, Heartland McNair Research Symposium Teaching Teaching Assistant, Experimental Psychology 1: Statistics. University of Notre Dame Spring, 2015 Teaching Assistant, Advanced Statistics. University of Notre Dame. Fall, 2015 Service Faculty Meeting Representative. 2015 Additional Visiting Student, VU University Amsterdam 2015 Research Department of Biological Psychology Experience Advisors: Gitta Lubke, Dorret Boomsma, Meike Bartels Intern, Center for Research Methods and Data Analysis 2009 - 2012 simsem: An R Package for Statistical Simulations with Structural Equation Models Advisors: Dr. Alex Schoemann, Dr. Sunthud Pornprasertmanit, Dr. Todd Little Programs for Data Cleaning and Handling for Driving Simulator Advisors: Dr. Mark Chan, Dr. John Geldhoff, Dr. Paul Atchley McNair Summer Research Internship Summer 2011 An R Interface for Matrix Multiplication Implemented on FPGA Advisor: Dr. Andy Gill Research Assistant, Department of Quantitative Psychology 2009-2010 Longitudinal Study of Mood - Principal Investigator: Ihno Lee Honors and Graduate Student Research Award 2015 Awards University of Notre Dame Excellence in Graduate Student Teaching Award 2015 University of Notre Dame Department of Psychology Graduate School Professional Development Award 2015 University of Notre Dame Outstanding Research by an Undergraduate 2012 University of Kansas Department of Psychology Best Use of Quantitative Methods 2012 University of Kansas Symposium for Undergraduate Psychology Research Ronald E. McNair Challenger Award 2012 McNair Scholars Summer Research Internship 2011 McNair Scholar, University of Kansas 2010.
Recommended publications
  • Vrije Universiteit Amsterdam Objects and Their Stories 1985-1990 Nick and Carst and the Netherlands Twin Register
    Vrije Universiteit Amsterdam objects and their stories 1985-1990 Nick and Carst and the Netherlands Twin Register There are many research institutes at VU Amsterdam. These institutes often bring together various disciplines around a specific theme. One of the more unusual topics is research on twins, which has been carried out at VU Amsterdam since the 1980s. This institute is represented in the collections in a unique way: with a work of art. Art curator Wende Wallert and Professor Dorret Boomsma from the Twin Institute tell us more. Nick and Carst By Wende Wallert In 2016, photographers Monique Eller and Bodine Koopmans made a series of portraits about the twin phenomenon entitled ‘DOUBLE DUTCH’, in collaboration with the NTR and VU Amsterdam. The results of their work were displayed in an exhibition in the Main Building. Set against a muted background, the portrait of Nick and Carst beautifully reveals their similarities and differences as well as the special bond that twins share. Monique Eller and Bodine Koopmans, Nick and Carst, 2016, VU VU Amsterdam aims to stimulate the interaction Amsterdam Art Collection between art and science. Like science, art offers us new insights, but from the imagination. In its own gallery space called WONDER, VU Amsterdam organises exhibitions and events to share current artistic and scientific research with the public. The Netherlands Twin Register By Dorret Boomsma I began my PhD studies at Vrije Universiteit Amsterdam in 1983, after completing a doctoral programme there and obtaining an MA at the Institute for Behavioural Genetics in Boulder, Colorado. It was in Boulder that I became aware of the value of twin studies.
    [Show full text]
  • ONFERENCE PROG the 13Th International
    ONFERENCE PROG C The 13th International Congress on Twin Studies June 4-7, 2010, Seoul, Korea cv mu"' f6ARtt Seoul c.cio4"J' RA7°J2-- U/1 TOURISM ORGANIZATION FRIDAY (JUNE 4) 18:30 -21:00 ICTS Welcome Reception (Regency Room) SATURDAY (JUNE 5) 7:30 - 8:15 Breakfast (Regency Room) Symposium : Genetics of high cognitive abilities Regency Room 815 - 9:45 Organizer: Robert Plomin Robert Plomin & Claire M. A. Haworth 8:15 Genetics of high cognitive abilities : An overview John Hewitt, Angela Brant, Robin Corley, Sally Wadsworth & John DeFries 8:30 A closer look at the developmental etiology of high IQ Matt McGue, Robert M. Kirkpatrick, Michael Miller, & William G. Iacono 8:45 The University of Minnesota Initiative on the Genetics of High Cognitive Ability Allan McRae, Margie Wright, Narelle Hansell, Peter Visscher, Grant Montgomery, & Nicholas G. Martin 9:00 Is high cognitive ability associated with a lower genomic burden of copy number variants? Dorret I. Boomsma, Catherina E.M. van Beijsterveldt, Inge van Soelen , Sanja Franio, Conor V. Dolan, Denny Borsboom,& M. Bartels 9:15 Genetic analysis of longitudinally measured IQ, educational attainment and educational level in Dutch twin-sib samples Paper Session : Twin studies of personality & psychological wellbeing Namsan Ill 8:15 - 9:45 Chair: Corrado Fagnani Christian Kandler, Wiebke Bleidorn, & Rainer Riemann 8:15 Sources of cumulative continuity in personality: A longitudinal multiple-rater twin study Veselka, L., Schermer, J.A., Martin, R. A., & Vernon, P.A. 8:30 The heritability of general factor of personality extracted in four different datasets Antonella Gigantesco, Corrado Fagnani, Guido Alessandri, Emanuela Medda, 8:45 Emanuele Tarolla, & Maria Antonietta Stazi An Italian twin study on psychological well-being in young adulthood Meike Bartels, Gonneke, A.H.M.
    [Show full text]
  • Genetics and Human Behaviour
    Cover final A/W13657 19/9/02 11:52 am Page 1 Genetics and human behaviour : Genetic screening: ethical issues Published December 1993 the ethical context Human tissue: ethical and legal issues Published April 1995 Animal-to-human transplants: the ethics of xenotransplantation Published March 1996 Mental disorders and genetics: the ethical context Published September 1998 Genetically modified crops: the ethical and social issues Published May 1999 The ethics of clinical research in developing countries: a discussion paper Published October 1999 Stem cell therapy: the ethical issues – a discussion paper Published April 2000 The ethics of research related to healthcare in developing countries Published April 2002 Council on Bioethics Nuffield The ethics of patenting DNA: a discussion paper Published July 2002 Genetics and human behaviour the ethical context Published by Nuffield Council on Bioethics 28 Bedford Square London WC1B 3JS Telephone: 020 7681 9619 Fax: 020 7637 1712 Internet: www.nuffieldbioethics.org Cover final A/W13657 19/9/02 11:52 am Page 2 Published by Nuffield Council on Bioethics 28 Bedford Square London WC1B 3JS Telephone: 020 7681 9619 Fax: 020 7637 1712 Email: [email protected] Website: http://www.nuffieldbioethics.org ISBN 1 904384 03 X October 2002 Price £3.00 inc p + p (both national and international) Please send cheque in sterling with order payable to Nuffield Foundation © Nuffield Council on Bioethics 2002 All rights reserved. Apart from fair dealing for the purpose of private study, research, criticism or review, no part of the publication may be produced, stored in a retrieval system or transmitted in any form, or by any means, without prior permission of the copyright owners.
    [Show full text]
  • Longitudinal Stability of the CBCL-Juvenile Bipolar Disorder Phenotype: a Study in Dutch Twins Dorret I
    Longitudinal Stability of the CBCL-Juvenile Bipolar Disorder Phenotype: A Study in Dutch Twins Dorret I. Boomsma, Irene Rebollo, Eske M. Derks, Toos C.E.M. van Beijsterveldt, Robert R. Althoff, David C. Rettew, and James J. Hudziak Background: The Child Behavior Checklist–juvenile bipolar disorder phenotype (CBCL-JBD) is a quantitative phenotype that is based on parental ratings of the behavior of the child. The phenotype is predictive of DSM-IV characterizations of BD and has been shown to be sensitive and specific. Its genetic architecture differs from that for inattentive, aggressive, or anxious–depressed syndromes. The purpose of this study is to assess the developmental stability of the CBCL-JBD phenotype across ages 7, 10, and 12 years in a large population-based twin sample and to examine its genetic architecture. Methods: Longitudinal data on Dutch mono- and dizygotic twin pairs (N ϭ 8013 pairs) are analyzed to decompose the stability of the CBCL-JBD phenotype into genetic and environmental contributions. Results: Heritability of the CBCL-JBD increases with age (from 63% to 75%), whereas the effects of shared environment decrease (from 20% to 8%). The stability of the CBCL-JBD phenotype is high, with correlations between .66 and .77 across ages 7, 10, and 12 years. Genetic factors account for the majority of the stability of this phenotype. There were no sex differences in genetic architecture. Conclusions: Roughly 80% of the stability in childhood CBCL-JBD is a result of additive genetic effects. Key Words: Childhood bipolar affective disorder, genetics, twins disorders (Kahana et al 2003) has been examined across samples, countries, and across methodologies (Althoff et al 2005).
    [Show full text]
  • IBD Estimation in Pedigrees
    23rd International Workshop on Statistical Genetics and Methodology of Twin and Family Studies: Advanced course Pak Sham (director) John Hewitt (host) Lindon Eaves Jeff Lessem Jeff Barrett Marleen de Moor David Evans Stacey Cherny Goncalo Abecasis Ben Neale Mike Neale Shaun Purcell Hermine Maes Manuel Ferreira Sarah Medland Nick Martin Dorret Boomsma Kate Morley Danielle Posthuma Allan McRae Meike Bartels Hunting QTLs – an introduction Nick Martin Queensland Institute of Medical Research Boulder workshop: March 2, 2009 Mendel 1865 – genetics of discrete traits Stature in adolescent twins Women 700 600 500 400 300 200 Std. Dev = 6.40 100 Mean = 169.1 0 N = 1785.00 145.0 155.0 165.0 175.0 185.0 150.0 160.0 170.0 180.0 190.0 Stature R.A. Fisher, 1918 The explanation of quantitative inheritance in Mendelian terms 1 Gene 2 Genes 3 Genes 4 Genes 3 Genotypes 9 Genotypes 27 Genotypes 81 Genotypes 3 Phenotypes 5 Phenotypes 7 Phenotypes 9 Phenotypes 3 3 7 20 6 15 2 2 5 4 10 3 1 1 2 5 1 0 0 0 0 Multifactorial Threshold Model of Disease Single threshold Multiple thresholds unaffected affected normal mild mod sever e Disease liability Disease liability Complex Trait Model Linkage Marker Gene1 Linkage disequilibrium Mode of Linkage inheritance Association Gene2 Disease Phenotype Individual environment Gene3 Common environment Polygenic background Using genetics to dissect metabolic pathways: Drosophila eye color Beadle & Ephrussi, 1936 Finding QTLs Linkage Association First (unequivocal) positional cloning of a complex
    [Show full text]
  • Netherlands Twin Register: from Twins to Twin Families
    THE NETHERLANDS Netherlands Twin Register: From Twins to Twin Families Dorret I. Boomsma, Eco J. C. de Geus, Jacqueline M. Vink, Janine H. Stubbe, Marijn A. Distel, Jouke-Jan Hottenga, Danielle Posthuma, Toos C. E. M. van Beijsterveldt, James J. Hudziak, Meike Bartels, and Gonneke Willemsen Department of Biological Psychology,Vrije Universiteit,Amsterdam, the Netherlands n the late 1980s The Netherlands Twin Register Rietveld et al., 2000; Stubbe et al., 2005: Vink et al., I(NTR) was established by recruiting young twins and 2004). In this paper we give an update on the ANTR multiples at birth and by approaching adolescent and and YNTR and describe some new developments in young adult twins through city councils. The Adult phenotyping and biobank studies. NTR (ANTR) includes twins, their parents, siblings, spouses and their adult offspring. The number of par- ANTR ticipants in the ANTR who take part in survey and / or laboratory studies is over 22,000 subjects. A special Table 1 offers a summary of the number of family group of participants consists of sisters who are members registered with the ANTR who participated mothers of twins. In the Young NTR (YNTR), data on at least once in one of the surveys or in one of the lab- more than 50,000 young twins have been collected. oratory studies. Families of adolescent and adult Currently we are extending the YNTR by including twins have been extended to include parents, siblings, siblings of twins. Participants in YNTR and ANTR spouses and offspring (over 18 years) of the twins and have been phenotyped every 2 to 3 years in longitudi- siblings.
    [Show full text]
  • UCLA Electronic Theses and Dissertations
    UCLA UCLA Electronic Theses and Dissertations Title Computational Genetic Approaches for Understanding the Genetic Basis of Complex Traits Permalink https://escholarship.org/uc/item/50j7w041 Author Kang, Eun Yong Publication Date 2013 Peer reviewed|Thesis/dissertation eScholarship.org Powered by the California Digital Library University of California UNIVERSITY OF CALIFORNIA Los Angeles Computational Genetic Approaches for Understanding the Genetic Basis of Complex Traits A dissertation submitted in partial satisfaction of the requirements for the degree Doctor of Philosophy in Computer Science by Eun Yong Kang 2013 c Copyright by Eun Yong Kang 2013 ABSTRACT OF THE DISSERTATION Computational Genetic Approaches for Understanding the Genetic Basis of Complex Traits by Eun Yong Kang Doctor of Philosophy in Computer Science University of California, Los Angeles, 2013 Professor Eleazar Eskin, Chair Recent advances in genotyping and sequencing technology have enabled researchers to collect an enormous amount of high-dimensional genotype data. These large scale genomic data provide unprecedented opportunity for researchers to study and analyze the genetic factors of human complex traits. One of the major challenges in analyzing these high-throughput genomic data is requirements for effective and efficient compu- tational methodologies. In this thesis, I introduce several methodologies for analyzing these genomic data which facilitates our understanding of the genetic basis of complex human traits. First, I introduce a method for inferring biological networks from high- throughput data containing both genetic variation information and gene expression profiles from genetically distinct strains of an organism. For this problem, I use causal inference techniques to infer the presence or absence of causal relationships between yeast gene expressions in the framework of graphical causal models.
    [Show full text]
  • An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression Phenotypea Susceptibility Locus for Broad Depression Phenotype
    Author’s Accepted Manuscript An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression PhenotypeA Susceptibility Locus for Broad Depression Phenotype Nese Direk, Stephanie Williams, Jennifer A. Smith, Stephan Ripke, Tracy Air, Azmeraw T. Amare, Najaf Amin, Bernhard T. Baune, David A. Bennett, www.elsevier.com/locate/journal Douglas H.R. Blackwood, Dorret Boomsma, Gerome Breen, Henriette N. Buttenschøn, Enda M. Byrne, Anders D. Børglum, Enrique Castelao, Sven Cichon, Toni-Kim Clarke, Marilyn C. Cornelis, Udo Dannlowski, Philip L. De Jager, Ayse Demirkan, Enrico Domenici, Cornelia M. van Duijn, Erin C. Dunn, Johan G. Eriksson, Tonu Esko, Jessica D. Faul, Luigi Ferrucci, Myriam Fornage, Eco de Geus, Michael Gill, Scott D. Gordon, Hans Jörgen Grabe, Gerard van Grootheest, Steven P. Hamilton, Catharina A. Hartman, Andrew C. Heath, Karin Hek, Albert Hofman, Georg Homuth, Carsten Horn, Jouke Jan Hottenga, Sharon L.R. Kardia, Stefan Kloiber, Karestan Koenen, Zoltán Kutalik, Karl-Heinz Ladwig, Jari Lahti, Douglas F. Levinson, Cathryn M. Lewis, Glyn Lewis, Qingqin S. Li, David J. Llewellyn, Susanne Lucae, Kathryn L. Lunetta, Donald J. MacIntyre, Pamela Madden, Nicholas G. Martin, Andrew M. McIntosh, Andres Metspalu, Yuri Milaneschi, Grant W. Montgomery, Ole Mors, Thomas H. Mosley, Joanne M. Murabito, Bertram Müller-Myhsok, Markus M. Nöthen, Dale R. Nyholt, Michael C. O’Donovan, Brenda W. Penninx, Michele L. Pergadia, Roy Perlis, James B. Potash, Martin Preisig, Shaun M. Purcell, Jorge A. Quiroz, Katri Räikkönen, John P. Rice, Marcella Rietschel, Margarita Rivera, Thomas G. Schulze, Jianxin Shi, Stanley Shyn, Grant C. Sinnamon, Johannes H. Smit, Jordan W.
    [Show full text]
  • Ollikainen, Miina Eliisa 10.01.2019 Tel. +358 50 415 1276 Email Miina
    Ollikainen, Miina Eliisa CV 10.01.2019 Tel. +358 50 415 1276 Email [email protected] Webpage http://epigenetics.helsinki.fi/ https://www.fimm.fi/en/research/groups/ollikainen Academic education and degrees 2013 Title of Docent in Epigenetics, University of Helsinki (UH), Finland 2007 Doctor of Philosophy (Medical Genetics), UH, Finland 2002 Master of Science (Genetics), UH, Finland Linguistic skills Finnish Mother tongue English Proficient user Current position Academy Research Fellow, Group Leader, Epigenetics of Complex Diseases and traits, Sept 2016- Place of work: Institute for Molecular Medicine Finland, FIMM, UH, Finland Research career phase: Established researcher, full time post My current research group includes Senior Researcher Milla Kibble (expert in applied mathematics), Postdoctoral researchers Emma Cazaly (PhD in molecular medicine), and Maheswary Muniandy (PhD in bioinformatics), and two full-time PhD students; Sailalitha Bollepalli (MSc in bioinformatics) and Yu Fu (MSc in translational medicine). My group also has a part-time biomedical laboratory scientist Ms Mia Urjansson who is responsible for sample collection and preparation, and assisting in the laboratory. Previous posts and work experience 2013- Group Leader, Department of Public Health, UH, Finland 2010 –2013 Junior Group Leader, Academy Postdoctoral Research Fellow, UH, Finland 2007 –2010 Postdoctoral Fellow, Developmental Epigenetics Research, Murdoch Children’s Research Institute, And University of Melbourne, Australia 2002 –2007 Graduate student, Department of Medical Genetics, UH, Finland 2000 –2001 Research assistant, Department of Biosciences, UH, Finland 1999 Undergraduate student, Folkhälsan Research Institute, Department of Medical Genetics, UH, Finland Career break: Maternity leave from 23rd of November 2013 until 31st of December 2014.
    [Show full text]
  • Dose Response of the 16P11.2 Distal Copy Number Variant on Intracranial Volume and Basal Ganglia
    Molecular Psychiatry (2020) 25:584–602 https://doi.org/10.1038/s41380-018-0118-1 ARTICLE Corrected: Correction Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia Ida E Sønderby et al. Received: 12 February 2018 / Revised: 2 May 2018 / Accepted: 25 May 2018 / Published online: 3 October 2018 © The Author(s) 2018. This article is published with open access Abstract Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes of 12 16p11.2 distal deletion and 12 duplication carriers to 6882 non-carriers from the large-scale brain Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent CNV calling procedures, and standardized FreeSurfer image analysis, we found negative dose-response associations with copy number on intracranial volume and on regional caudate, pallidum and putamen volumes (β = −0.71 to −1.37; P < 0.0005). In an independent sample, consistent results were obtained, with significant effects in the pallidum (β = −0.95, P = 0.0042). The two data sets combined showed fi = −6 −9 1234567890();,: 1234567890();,: signi cant negative dose-response for the accumbens, caudate, pallidum, putamen and ICV (P 0.0032, 8.9 × 10 , 1.7 × 10 , 3.5 × 10−12 and 1.0 × 10−4, respectively). Full scale IQ was lower in both deletion and duplication carriers compared to non- carriers. This is the first brain MRI study of the impact of the 16p11.2 distal CNV, and we demonstrate a specific effect on subcortical brain structures, suggesting a neuropathological pattern underlying the neurodevelopmental syndromes.
    [Show full text]
  • Avera Institute for Human Genetics (AIHG) Studies, Are Key to Science-Driven Innovation in Health Care
    Avera Avera & VU Scientific Committee Institute for A Scientific Committee directs initiatives through the expanded Avera and VU partnership. They are Human Genetics at the leading-edge in transforming medicine because large-scale genotype/phenotype infrastructures, like twin The Avera Institute for Human Genetics (AIHG) studies, are key to science-driven innovation in health care. has a history of excellence and an exciting Distinguished members of the committee include: future in innovative genetics research. As a state-of-the-art human molecular genetics laboratory fully equipped with advanced Gareth Davies, PhD technology, they undertake a wide range Gareth Davies, PhD, Chief Scientific of research projects, including personalized Officer and Scientific Director at AIHG, medicine, biobanking, tumor registries, is a Molecular Geneticist with an and behavioral and cancer genetic studies. interest in the genetics of complex By advancing science through numerous traits including behavioral, neuropsychiatric partnerships – both nationally and internationally and developmental disorders. Since 2007, – AIHG is poised to translate this knowledge Davies has concentrated his research on to improve the care provided to Avera patients the molecular genetic analysis of twins and communities. as part of a National Institutes of Health-funded collaboration with the Since 2009, the AIHG has partnered with the NTR. He has extensive experience in world’s leading twin register, the Netherlands coordinating this international partnership Twin Register (NTR) at Vrije Universiteit (VU). and creating a strong infrastructure to With the launch of the Avera Twin Register, support this and future large-scale projects. they now collect and analyze DNA from twins In addition, Davies directs studies in throughout the Midwest and the Netherlands cancer and pharmacogenomics.
    [Show full text]
  • Department of Psychology 118 Haggar Hall Notre Dame in 46556 [email protected]
    01/10/2016 Curriculum Vitae Gitta Lubke Mailing Address University of Notre Dame Department of Psychology 118 Haggar Hall Notre Dame IN 46556 [email protected] Higher Education 1997-2002 PhD, Psychometrics, VU University Amsterdam, The Netherlands 1993-1997 Undergraduate Education & MA (cum laude), University of Amsterdam, The Netherlands Positions 2008-present Associate Professor, Department of Psychology, University of Notre Dame 2010-present Visiting Professor, Biological Psychology, VU University Amsterdam 2004-2008 John Cardinal O'Hara, C.S.C. Assistant Professor, Department of Psychology, University of Notre Dame 2003-2004 Assistant Professor, Department of Psychiatry, VIPBG, Virginia Commonwealth University 2001-2003 Research Associate, Graduate School of Education & Information Studies, UCLA, Supervisor: Bengt Muthén Honors and Awards 2009 Tanaka Award, most outstanding paper published in Multivariate Behavioral Research in 2008 2007 Cattell Award, Outstanding Early Career Contributions to Multivariate Psychology, Society of Multivariate Experimental Psychology Publications Miller PJ, Lubke GH, McArtor DB, Bergeman CS (submitted). Finding structure in data: A data mining alternative to multivariate multiple regression. GL- 1 01/10/2016 McArtor DB, Lubke GH (submitted). Extending multivariate distance matrix regression with an effect size measure and the distribution of the test statistic Nivard MG, Middeldorp CM, Lubke GH, Hottenga JJ, Abdellaoui A, Boomsma DI, Dolan CV (submitted). Detection of gene –environment interaction in pedigree data using genome-wide genotypes. Nivard MG, Lubke GH, Dolan CV, Evans DM, St Pourcain B, Munafò MR, Middeldorp CM. (submitted) Joint developmental trajectories of internalizing and externalizing disorders between childhood and adolescence. Laurin C, Walters R, Boomsma DI, Lubke GH (submitted). The use of vector bootstrapping to improve variable selection precision in Lasso models.
    [Show full text]