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Ollikainen, Miina Eliisa 10.01.2019 Tel. +358 50 415 1276 Email Miina Ollikainen, Miina Eliisa CV 10.01.2019 Tel. +358 50 415 1276 Email [email protected] Webpage http://epigenetics.helsinki.fi/ https://www.fimm.fi/en/research/groups/ollikainen Academic education and degrees 2013 Title of Docent in Epigenetics, University of Helsinki (UH), Finland 2007 Doctor of Philosophy (Medical Genetics), UH, Finland 2002 Master of Science (Genetics), UH, Finland Linguistic skills Finnish Mother tongue English Proficient user Current position Academy Research Fellow, Group Leader, Epigenetics of Complex Diseases and traits, Sept 2016- Place of work: Institute for Molecular Medicine Finland, FIMM, UH, Finland Research career phase: Established researcher, full time post My current research group includes Senior Researcher Milla Kibble (expert in applied mathematics), Postdoctoral researchers Emma Cazaly (PhD in molecular medicine), and Maheswary Muniandy (PhD in bioinformatics), and two full-time PhD students; Sailalitha Bollepalli (MSc in bioinformatics) and Yu Fu (MSc in translational medicine). My group also has a part-time biomedical laboratory scientist Ms Mia Urjansson who is responsible for sample collection and preparation, and assisting in the laboratory. Previous posts and work experience 2013- Group Leader, Department of Public Health, UH, Finland 2010 –2013 Junior Group Leader, Academy Postdoctoral Research Fellow, UH, Finland 2007 –2010 Postdoctoral Fellow, Developmental Epigenetics Research, Murdoch Children’s Research Institute, And University of Melbourne, Australia 2002 –2007 Graduate student, Department of Medical Genetics, UH, Finland 2000 –2001 Research assistant, Department of Biosciences, UH, Finland 1999 Undergraduate student, Folkhälsan Research Institute, Department of Medical Genetics, UH, Finland Career break: Maternity leave from 23rd of November 2013 until 31st of December 2014. Other Experience and Professional Memberships 2018 - Member of the Editorial Board of Epigenomes 2018- Member of the Editorial Board of Clinical Epigenetics 2017 ERC Consolidator Grant reviewer 2017 Grant reviewer for Dutch Heart Foundation, The Netherlands 2016- Member of the Doctoral Training Committee at FIMM, UH 2016 Grant reviewer for Wetenschappelijk Fonds Willy Gepts, Belgium 2013- PhD thesis pre-examiner of multiple PhD theses, UH 2013- Member of the Finnish Twin Cohort Study Steering Group 2013-2017 Site-specific co-PI in EpiTRAIN Marie Curie Initial Training Network 2010-2012 Member of the ENGAGE Epigenomics Flagship core team responsible for the epigenetic analyses 2010- Review Editor at the Frontiers in Epigenomics and Epigenetics Internationality April-May 2011, Visiting Scientist at the MCRI, Melbourne, Australia August 2007- July 2010, Postdoctoral research fellow at the MCRI, Melbourne, Australia February 2006, visiting PhD student at the Mutation Analysis core Facility, Karolinska Institutet, Stockholm, Sweden Research funding Ongoing Research Support 2018-2020 The Sigrid Juselius Foundation Young Researcher grant 2016-2021 The Academy of Finland, Academy Research Fellow 1 2016-2019 The Academy of Finland, Research costs of ARF 2014-2018 University of Helsinki, Research grant Completed Research Support (last 3 years) 2011-2017 The Sigrid Juselius Foundation Homing grant 2011-2015 The Academy of Finland, Postdoctoral Fellow Received funding as part of a research team 2014-2019 NIH/NIAAA, Grant ID: 2R01 AA015416-A1, “Gene-environment interplay in the development of alcohol use and related problems”, PI A/Prof Danielle Dick, Virginia Commonwealth University, Richmond, VA, USA. MO University of Helsinki partner team member. 2014-2019 FP7-HEALTH-2013-INNOVATION-1, Project 602768, EC FP7 “ACTION, Aggression in Children: Unravelling gene- environment Interplay to inform Treatment and intervention strategy”, PI Professor Dorret Boomsma, Free University, Amsterdam, The Netherlands. MO University of Helsinki partner team member. 2013-2017 FP7-PEOPLE-2012-ITN, Marie Curie Initial Training Networks, “EpiTrain, Epigenetic Training Network – Innovative techniques and models to understand epigenetic regulation in the pathogenesis of common Diseases”, PI Professor Timothy Spector, King’s College London, UK. MO site specific co-PI. Supervision experience Appointed main PhD thesis supervisor of MSc Maheswary Muniandy (PhD in 2018), MSc Richa Gupta (PhD in 2018), MSc Sailalitha Bollepalli, MSc Aileen Bahl, MSc Yu Fu, and MSc Khadeeja Ismail Appointed Master’s thesis supervisor of BSc Maheswary Muniandy (MSc 2014), and BSc Khadeeja Ismail (MSc 2012) Supervisor for summer internships of Julie Alexandre (2012) and BSc Nelli Roininen (2011) Appointed co-supervisor of an Advanced Medical Science thesis of Nur Khairunnisa Abdul Aziz (2009) Teaching 2018- Lecture on epigenomics in “Principles of Bioscience Omics” course, module “ Genomics, Epigenomics and Transcriptomics”, for undergraduate and graduate students, at the Faculty of Biological and Environmental Sciences, and Faculty of Medicine, UH. 2017 Organizer of Epigenetics Workshop at the International Society for Twin Studies congress, Madrid, Spain 2017 Organizer of the Building Bridges: Epigenetics in Clinical and Translational Research, UH 2016 Organizer of the Epigenetics Workshop at The Society for Research on Nicotine & Tobacco Europe conference, Prague, Czech Republic 2016 Epigenetics Journal Club, for graduate students of Doctoral Programs, UH 2014 - Running an advanced course on “Environmental Epigenetics” for undergraduate and graduate students, at the Faculty of Biological and Environmental Sciences, UH. This course include 16h of lectures and lecture diary. 2012 –2015 Lectures on “DNA Microarray applications: Epigenetics” for undergraduate students of the Eu-SYSBIO MSc program, UH. 2011-2013 Lectures on “What are DNA, genes, epigenetics?” for undergraduate students at the Department of Behavioural Sciences, University of Helsinki. 2003 Gene technology and microbial genetics –practical courses for Master’s students at the Department of Biosciences, University of Helsinki 2010 - Several lectures in seminar series at the Department of Public Health, FIMM and Department of Medical Genetics, UH, and University of Turku. Material for teaching: - book chapter: “Bisulphite-enabled technologies” in Epigenetics, A reference manual text book - book chapter: ”Epigenetics” in Behavioral genetics – From genes to populations, text book in Finnish (”Epigenetiikka”, Käyttäytymisgenetiikka – geeneistä yhteiskuntaan) Scientific and societal impact of research I have published 39 peer-reviewed papers and my h-index is 23 (GoogleScholar). I have also published two book chapters “Bisulphite-enabled techniques” and “Epigenetics” (in Finnish “Epigenetiikka“) and three articles in Finnish in Yliopistolehti, Tehy, and Duodecim. Link to full list of my publications. 2 LIST OF MOST RECENT PUBLICATIONS Sillanpää E, Ollikainen M, Kaprio J,Wang X, Leskinen T, Kujala UM, Törmäkangas T. Leisure-time physical activity and DNA methylation age - a twin study. Clin Epigenetics. 2019, in press. Gupta R, van Dongen J, Fu Y, Abdellaoui A, Tyndale RF, Velagapudi V, Boomsma DI, Korhonen T, Kaprio J, Loukola A, Ollikainen M. Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci. Clin Epigenetics. 2019 Jan 5;11(1):1. doi: 10.1186/s13148-018-0606-9. Muniandy M, Velagapudi V, Hakkarainen A, Lundbom J, Lundbom N, Rissanen A, Kaprio J, Pietiläinen KH, Ollikainen M. Plasma metabolites reveal distinct profiles associating with different metabolic risk factors in monozygotic twin pairs. Int J Obes (Lond). 2018 Jun 15. doi: 10.1038/s41366-018-0132-z Bollepalli S, Kaye S, Heinonen S, Kaprio J, Rissanen A, Virtanen KA, Pietiläinen KH, Ollikainen M. Subcutaneous adipose tissue gene expression and DNA methylation respond to both short- and long-term weight loss. Int J Obes (Lond). 2018 Mar;42(3):412-423. Sillanpää, E., Laakkonen, E. K., Vaara, E., Rantanen, T., Kovanen, V., Sipilä, S., Kaprio, J. & Ollikainen, M. Biological clocks and physical functioning in monozygotic female twins. 2018, BMC Geriatrics. 18:83 Huang Y, Ollikainen M, Sipilä P, Mustelin L, Wang X, Su S, Huan T, Levy D, Wilson J, Snieder H, Kaprio J, Wang X. Genetic and Environmental Effects on Gene Expression Signatures of Blood Pressure: A Transcriptome-Wide Twin Study. Hypertension. 2018 Mar;71(3):457-464. Tsai PC, Glastonbury CA, Eliot MN, Bollepalli S, Yet I, Castillo-Fernandez JE, Carnero-Montoro E, Hardiman T, Martin TC, Vickers A, Mangino M, Ward K, Pietiläinen KH, Deloukas P, Spector TD, Viñuela A, Loucks E, Ollikainen M, Kelsey KT, Small KS, Bell JT. Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health. Clin Epigenetics. 2018 Oct 20;10(1):126. Karlsson Linnér R, Marioni RE, …, Ollikainen M, …, Deary IJ, Koellinger PD, Benjamin DJ. An epigenome-wide association study meta-analysis of educational attainment. Mol Psychiatry. 2017 Dec;22(12):1680-1690. Gupta R, Qaiser B, He L, Hiekkalinna TS, Zheutlin AB, Therman S, Ollikainen M, Ripatti S, Perola M, Salomaa V, Milani L, Cannon TD, Madden PAF, Korhonen T, Kaprio J, Loukola A. Neuregulin signaling pathway in smoking behavior. Transl Psychiatry. 2017 Aug 22;7(8):e1212. Muniandy M, Heinonen S, Yki-Järvinen H, Hakkarainen A, Lundbom J, Lundbom N, Kaprio J, Rissanen A, Ollikainen M, Pietiläinen KH. Gene expression profile of subcutaneous adipose tissue in BMI-discordant monozygotic twin pairs unravels molecular and clinical changes associated
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