ONFERENCE PROG the 13Th International

Total Page:16

File Type:pdf, Size:1020Kb

ONFERENCE PROG the 13Th International ONFERENCE PROG C The 13th International Congress on Twin Studies June 4-7, 2010, Seoul, Korea cv mu"' f6ARtt Seoul c.cio4"J' RA7°J2-- U/1 TOURISM ORGANIZATION FRIDAY (JUNE 4) 18:30 -21:00 ICTS Welcome Reception (Regency Room) SATURDAY (JUNE 5) 7:30 - 8:15 Breakfast (Regency Room) Symposium : Genetics of high cognitive abilities Regency Room 815 - 9:45 Organizer: Robert Plomin Robert Plomin & Claire M. A. Haworth 8:15 Genetics of high cognitive abilities : An overview John Hewitt, Angela Brant, Robin Corley, Sally Wadsworth & John DeFries 8:30 A closer look at the developmental etiology of high IQ Matt McGue, Robert M. Kirkpatrick, Michael Miller, & William G. Iacono 8:45 The University of Minnesota Initiative on the Genetics of High Cognitive Ability Allan McRae, Margie Wright, Narelle Hansell, Peter Visscher, Grant Montgomery, & Nicholas G. Martin 9:00 Is high cognitive ability associated with a lower genomic burden of copy number variants? Dorret I. Boomsma, Catherina E.M. van Beijsterveldt, Inge van Soelen , Sanja Franio, Conor V. Dolan, Denny Borsboom,& M. Bartels 9:15 Genetic analysis of longitudinally measured IQ, educational attainment and educational level in Dutch twin-sib samples Paper Session : Twin studies of personality & psychological wellbeing Namsan Ill 8:15 - 9:45 Chair: Corrado Fagnani Christian Kandler, Wiebke Bleidorn, & Rainer Riemann 8:15 Sources of cumulative continuity in personality: A longitudinal multiple-rater twin study Veselka, L., Schermer, J.A., Martin, R. A., & Vernon, P.A. 8:30 The heritability of general factor of personality extracted in four different datasets Antonella Gigantesco, Corrado Fagnani, Guido Alessandri, Emanuela Medda, 8:45 Emanuele Tarolla, & Maria Antonietta Stazi An Italian twin study on psychological well-being in young adulthood Meike Bartels, Gonneke, A.H.M. Willemsen, Niels van der Aa, Toos, C.E.M. 9:00 van Beijsterveldt, & Dorret I. Boomsma 1 Robert Lyle, Kristina Gervin, Gregor Gilfillan, Hanne E. Akselsen, Martin Subjective wellbeing and religion: Investigating effects of gene by environment 10:45 Hamer-0, Rune Moe, Hakon Gjessing, Jennifer Harris, & Dag E. Undlien interaction Christian Kandler, Wiebke Bleidorn, & Rainer Riemann Studying the extent and function of epigenetic variation in twins 9:15 Jennifer R. Harris, Kristina Gervin, Gregor Gilfillan, Hanne E. Akselsen, Martin Life events as environmental states and genetic traits and the role of 11:00 Hannero, Rune Moe, Hakon Gjessing, Dag E. Undlien, & Robert Lyle personality Sources of epigenetic variation in the MHC Emma Dempster, Ruth Pidsley, Leo Schalkwyk, Timothea Toulopoulou, Marco 11:15 Picchioni, Eugenia Kravariti, Robin Murray, & Jonathan Mill e ession : Comparison of natural vs. ART twin pregnancy Namsan V Epigenetic profiling in monozygotic twins discordant for major psychosis. 8:15 9:45 outcome - Chloe Chung Yi Wong, Avshalom Caspi, Benjamin Williams, Ian W. Craig, Chair: Nils Lambalk Renate Houts, Antony Ambler, Terrie E. Moffitt, & Jonathan Mill 11:30 Dorret Boomsma Methylomic profiling in discordant MZ twins: applications to psychiatric 8:15 phenotypes' Comparison of Natural and induced DZ twins in the Dutch Twin Registry: A developmental study Anja Pinborg 8:30 Symposium Vanishing twins in IVF 0:15-11:4 Genetics of Tobacco Use and Nicotine Dependence Namsan Ill Lambalk, C.B., Vink J, Van der Stroom E., & Boomsma, D.I Organizer: Tellervo Korhonen 8:45 Nationwide comparison of perinatal outcome of induced versus natural twins Nicholas G. Martin 10:15 in the Netherlands 2000-2008 A genomewide association study of nicotine and alcohol dependence in Michele Hansen, Lyn Colvin, Beverly Petterson, Jennifer J. Kurinczuk , Australian and Dutch Populations Nicholas de Klerk , & Carol Bower Jingchun Chen, Kenneth S Kendler, & Xiangning Chen 9:00 Kia Jackson, Twins born following assisted reproductive technology: perinatal outcome and 10:30 1 with nicotine admission to hospital Neuregulin association dependence Finn Rasmussen, Karin Modig Wennerstad , Karri Silventoinen, Per Tynelius, Lars Bergman, & Jaakko Kaprio 9:45- 10:15 Coffee Break 10:45 Intelligence, smoking habits and nicotine dependence among Swedish male twin pairs. Symposium: Tellervo Korhonen 11:00 Epigenetic mechanisms uncovered: novel uses of Regency Room Cigarette smoking / nicotine dependence and depression: Mechanisms of co- 10:15-11:45 twins occurrence . Kaisu Keskitalo-Vuokko, Tellervo Korhonen, &Jaakko Kaprio - Organ! . , zalaillailialliiiiiiillariliMik 11:15 Jordana T. Bell, Craig L. Hyde , Juliette M. Harris , Graham J. Brock , Frances Gene-environment interactions between depressive symptoms and smoking , , Burgess , Sally John , & Tim Spector 10:15 M.K. Williams Wang Jun Gillian quantity / . 0 Hermine Maes ,dl.,, Twin meth lation differences at the seuence level i J.M. Craig, R. Andronikos, M. 011ikainen, E.J. Joo, N. Carson, X Li, B Genetic epidemiology of cigarette and snus use in adult twins Weinrich, L. Gordon, R. Morley, J Galati, K Smith, J. Carlin, G. Smyth, 10:30 & R. Saffery Plenary Lecture Epigenetic studies of a newborn twin cohort: insights into prenatal development 11:45-12:15 Robert Plomin: Behavioral genetics in the era of Regency Room molecular genetics: Learning abilities and disabilities as examples - 2 - 3 14:30 Pekka Santtila, Ada Johansson, Bettina von der Pahlen, & N. Kenneth Sandnabba 10:15-12:15 COMBO Organizer:Kimberley Weatherall Namsan V 10:15 Kimberley Weatherall The dopamine transporter gene (DAT1) polymorphism moderates the effects of alcohol use on aggressive behaviour in men Introduction/Welcome Nancy Segal, & Iris Blandon-Gitlin 10:35 Gail Moore (Canada) 14:45 Suicidal behaviors in twins whose co-twins deaths were suicides and non- National Multiple Births Awareness Day - Multiple Births Canada (MBC) suicides 10:55 Gail Moore (COMBO) " Paper Session: Introduction of new twin registries; updates on International Multiple Births Awareness Day 13:15-14:45 existing registries Namsan III 11:15 Syuichi Ooki M.D. Ph. D. (Japan) Chair: Jack Goldberg Japan's Multiple Birth Association (JAMBA)_ Jahanfar Shayesteh 11:35 Monica Rankin (Australia) 13:15 Establishment of National Malaysian Twin Registry: challenges and Australia Multiple Birth Association (AMBA) opportunities 11:55 Sabine Herbener (Switzerland) Cesar G. Demayo, Astrid L. Sinco, Marites L. Bonachita-Sanguila , & Mark Anthony J. Torres 13:30 Association Jumeaux - Switzerland Twin registry in Mindanao, Philippines: Issues and Concerns Dedra Buchwald, Eric Strachan, Niloo Afari, Corinne Hunt, & Jack Goldberg 12:15-13:15 Lunch (Foyer on the 2nd Fl ) 13:45 Building a Unique U.S. Twin Registry: How I Lost My Drivers License and Founded a Twin Registry Paper Session: Goldberg, Christopher W. Forsberg, Jennifer Sporleder, Gene-environment interactions in alcohol Jack & Nicholas Smith 13:15-14:45 use/dependence and psychopathology Regency Room 14:00 . How did that happen?: Correcting zygosity assignment in air: Kerry Jang the Vietnam Era Twin Registry Kerry L. Jang, Steven Taylor, & Gordon J. G. Asmundson Ordoriana, JR; Rebollo, I; Carrillo, E; Colodro, L; Gonzalez-Javier, F; 13:15 Sanchez-Romera, JF; Perez-Riquelme, F; Perez-Valera, S; & Martinez-Selva, Etiology of Obsessions and Compulsions: A Behavioral-Genetic Analysis JM Sylvana C.C. Robbers, Floor V.A. van Oort, Tinca, J.C. Polderman, Meike 14:15 Bartels, Gitta H. Lubke, Frank C. Verhulst, Dorret I Boomsma, & Anja C. Development of a population-based registry of adult females in Spain: The 13:30 Huizink Murcia Twin Registry Hopper JL, Foley D, de Klerk, & Boadle J Trajectories of attention problems in childhood Angelica Ronald 14:30 Australian Twin Registry - realising the full potential of research involving 13:45 twins to improve the health and wellbeing of all Australians A twin study exploring the association between prenatal and neonatal complications and autistic spectrum disorders ... Eivind Ystrom 14:00 13:15-14:45 COMBO Namsan V The diagnostic stability and heritability of alcohol dependence Danielle Dick Mari Kaihovaara (Finland) 14:15 13:15 The Psychosocial well-being and financial surviving of multiple birth families in Understanding Gene-Environment Interactions in Adolescent Alcohol Use and Finland Externalizing Behavior COMBO Business meeting -4 5 SUNDAY (JUNE 6) 14:45-15:15 Coffee Break 7:30-8:15 Breakfast Plenary Lecture Plenary Reviews 8:15-8:45 Young Ki Paik: Global Human Proteome Project and Regency Room Dorret Boomsma: Behavior and psychiatry Disease Biomarker Discovery for the Nicholas G. Martin: Contributions of twin studies towards Personalized 15:15-16:45 Regency Room Medicine elucidating disease etiology Nils Lambalk: The multiple pregnancy; recent highlights Symposium : of obstetrical research. Regency Room Aging in twins: From molecules to appearance 8:45-10:15 Presidential Address Chair: Kaare Christensen Christian Garm, Tinna Stevnsner, Vilhelm Bohr, & Kaare Christensen 8:45 How Twins Saved Psychology, and What Psychology Has 16:45- 17:15 Twin Study on DNA repair efficiency Given in Return and human aging Regency Room Mikael Thinggaard, Jakob Mortensen, & Kaare Christensen 9:00 (Matt McGue) Changes in percieved age and mortality Feldman AL, Eriksson UK, Johansson ALV, Gatz M, Pedersen NL, & Wirdefeldt K 9:15 Risk of Dementia in Twins with Parkinsonian Disorders Paulo Ferreira, Manuela Ferreira, Chris Maher, John Hopper, Rachel Huxley, Cristina Alcantara, & Luci McGrath-Cadell 9:30 What is the research involving twins and low back pain telling us? A systematic review
Recommended publications
  • Vrije Universiteit Amsterdam Objects and Their Stories 1985-1990 Nick and Carst and the Netherlands Twin Register
    Vrije Universiteit Amsterdam objects and their stories 1985-1990 Nick and Carst and the Netherlands Twin Register There are many research institutes at VU Amsterdam. These institutes often bring together various disciplines around a specific theme. One of the more unusual topics is research on twins, which has been carried out at VU Amsterdam since the 1980s. This institute is represented in the collections in a unique way: with a work of art. Art curator Wende Wallert and Professor Dorret Boomsma from the Twin Institute tell us more. Nick and Carst By Wende Wallert In 2016, photographers Monique Eller and Bodine Koopmans made a series of portraits about the twin phenomenon entitled ‘DOUBLE DUTCH’, in collaboration with the NTR and VU Amsterdam. The results of their work were displayed in an exhibition in the Main Building. Set against a muted background, the portrait of Nick and Carst beautifully reveals their similarities and differences as well as the special bond that twins share. Monique Eller and Bodine Koopmans, Nick and Carst, 2016, VU VU Amsterdam aims to stimulate the interaction Amsterdam Art Collection between art and science. Like science, art offers us new insights, but from the imagination. In its own gallery space called WONDER, VU Amsterdam organises exhibitions and events to share current artistic and scientific research with the public. The Netherlands Twin Register By Dorret Boomsma I began my PhD studies at Vrije Universiteit Amsterdam in 1983, after completing a doctoral programme there and obtaining an MA at the Institute for Behavioural Genetics in Boulder, Colorado. It was in Boulder that I became aware of the value of twin studies.
    [Show full text]
  • Genetics and Human Behaviour
    Cover final A/W13657 19/9/02 11:52 am Page 1 Genetics and human behaviour : Genetic screening: ethical issues Published December 1993 the ethical context Human tissue: ethical and legal issues Published April 1995 Animal-to-human transplants: the ethics of xenotransplantation Published March 1996 Mental disorders and genetics: the ethical context Published September 1998 Genetically modified crops: the ethical and social issues Published May 1999 The ethics of clinical research in developing countries: a discussion paper Published October 1999 Stem cell therapy: the ethical issues – a discussion paper Published April 2000 The ethics of research related to healthcare in developing countries Published April 2002 Council on Bioethics Nuffield The ethics of patenting DNA: a discussion paper Published July 2002 Genetics and human behaviour the ethical context Published by Nuffield Council on Bioethics 28 Bedford Square London WC1B 3JS Telephone: 020 7681 9619 Fax: 020 7637 1712 Internet: www.nuffieldbioethics.org Cover final A/W13657 19/9/02 11:52 am Page 2 Published by Nuffield Council on Bioethics 28 Bedford Square London WC1B 3JS Telephone: 020 7681 9619 Fax: 020 7637 1712 Email: [email protected] Website: http://www.nuffieldbioethics.org ISBN 1 904384 03 X October 2002 Price £3.00 inc p + p (both national and international) Please send cheque in sterling with order payable to Nuffield Foundation © Nuffield Council on Bioethics 2002 All rights reserved. Apart from fair dealing for the purpose of private study, research, criticism or review, no part of the publication may be produced, stored in a retrieval system or transmitted in any form, or by any means, without prior permission of the copyright owners.
    [Show full text]
  • Longitudinal Stability of the CBCL-Juvenile Bipolar Disorder Phenotype: a Study in Dutch Twins Dorret I
    Longitudinal Stability of the CBCL-Juvenile Bipolar Disorder Phenotype: A Study in Dutch Twins Dorret I. Boomsma, Irene Rebollo, Eske M. Derks, Toos C.E.M. van Beijsterveldt, Robert R. Althoff, David C. Rettew, and James J. Hudziak Background: The Child Behavior Checklist–juvenile bipolar disorder phenotype (CBCL-JBD) is a quantitative phenotype that is based on parental ratings of the behavior of the child. The phenotype is predictive of DSM-IV characterizations of BD and has been shown to be sensitive and specific. Its genetic architecture differs from that for inattentive, aggressive, or anxious–depressed syndromes. The purpose of this study is to assess the developmental stability of the CBCL-JBD phenotype across ages 7, 10, and 12 years in a large population-based twin sample and to examine its genetic architecture. Methods: Longitudinal data on Dutch mono- and dizygotic twin pairs (N ϭ 8013 pairs) are analyzed to decompose the stability of the CBCL-JBD phenotype into genetic and environmental contributions. Results: Heritability of the CBCL-JBD increases with age (from 63% to 75%), whereas the effects of shared environment decrease (from 20% to 8%). The stability of the CBCL-JBD phenotype is high, with correlations between .66 and .77 across ages 7, 10, and 12 years. Genetic factors account for the majority of the stability of this phenotype. There were no sex differences in genetic architecture. Conclusions: Roughly 80% of the stability in childhood CBCL-JBD is a result of additive genetic effects. Key Words: Childhood bipolar affective disorder, genetics, twins disorders (Kahana et al 2003) has been examined across samples, countries, and across methodologies (Althoff et al 2005).
    [Show full text]
  • IBD Estimation in Pedigrees
    23rd International Workshop on Statistical Genetics and Methodology of Twin and Family Studies: Advanced course Pak Sham (director) John Hewitt (host) Lindon Eaves Jeff Lessem Jeff Barrett Marleen de Moor David Evans Stacey Cherny Goncalo Abecasis Ben Neale Mike Neale Shaun Purcell Hermine Maes Manuel Ferreira Sarah Medland Nick Martin Dorret Boomsma Kate Morley Danielle Posthuma Allan McRae Meike Bartels Hunting QTLs – an introduction Nick Martin Queensland Institute of Medical Research Boulder workshop: March 2, 2009 Mendel 1865 – genetics of discrete traits Stature in adolescent twins Women 700 600 500 400 300 200 Std. Dev = 6.40 100 Mean = 169.1 0 N = 1785.00 145.0 155.0 165.0 175.0 185.0 150.0 160.0 170.0 180.0 190.0 Stature R.A. Fisher, 1918 The explanation of quantitative inheritance in Mendelian terms 1 Gene 2 Genes 3 Genes 4 Genes 3 Genotypes 9 Genotypes 27 Genotypes 81 Genotypes 3 Phenotypes 5 Phenotypes 7 Phenotypes 9 Phenotypes 3 3 7 20 6 15 2 2 5 4 10 3 1 1 2 5 1 0 0 0 0 Multifactorial Threshold Model of Disease Single threshold Multiple thresholds unaffected affected normal mild mod sever e Disease liability Disease liability Complex Trait Model Linkage Marker Gene1 Linkage disequilibrium Mode of Linkage inheritance Association Gene2 Disease Phenotype Individual environment Gene3 Common environment Polygenic background Using genetics to dissect metabolic pathways: Drosophila eye color Beadle & Ephrussi, 1936 Finding QTLs Linkage Association First (unequivocal) positional cloning of a complex
    [Show full text]
  • Netherlands Twin Register: from Twins to Twin Families
    THE NETHERLANDS Netherlands Twin Register: From Twins to Twin Families Dorret I. Boomsma, Eco J. C. de Geus, Jacqueline M. Vink, Janine H. Stubbe, Marijn A. Distel, Jouke-Jan Hottenga, Danielle Posthuma, Toos C. E. M. van Beijsterveldt, James J. Hudziak, Meike Bartels, and Gonneke Willemsen Department of Biological Psychology,Vrije Universiteit,Amsterdam, the Netherlands n the late 1980s The Netherlands Twin Register Rietveld et al., 2000; Stubbe et al., 2005: Vink et al., I(NTR) was established by recruiting young twins and 2004). In this paper we give an update on the ANTR multiples at birth and by approaching adolescent and and YNTR and describe some new developments in young adult twins through city councils. The Adult phenotyping and biobank studies. NTR (ANTR) includes twins, their parents, siblings, spouses and their adult offspring. The number of par- ANTR ticipants in the ANTR who take part in survey and / or laboratory studies is over 22,000 subjects. A special Table 1 offers a summary of the number of family group of participants consists of sisters who are members registered with the ANTR who participated mothers of twins. In the Young NTR (YNTR), data on at least once in one of the surveys or in one of the lab- more than 50,000 young twins have been collected. oratory studies. Families of adolescent and adult Currently we are extending the YNTR by including twins have been extended to include parents, siblings, siblings of twins. Participants in YNTR and ANTR spouses and offspring (over 18 years) of the twins and have been phenotyped every 2 to 3 years in longitudi- siblings.
    [Show full text]
  • UCLA Electronic Theses and Dissertations
    UCLA UCLA Electronic Theses and Dissertations Title Computational Genetic Approaches for Understanding the Genetic Basis of Complex Traits Permalink https://escholarship.org/uc/item/50j7w041 Author Kang, Eun Yong Publication Date 2013 Peer reviewed|Thesis/dissertation eScholarship.org Powered by the California Digital Library University of California UNIVERSITY OF CALIFORNIA Los Angeles Computational Genetic Approaches for Understanding the Genetic Basis of Complex Traits A dissertation submitted in partial satisfaction of the requirements for the degree Doctor of Philosophy in Computer Science by Eun Yong Kang 2013 c Copyright by Eun Yong Kang 2013 ABSTRACT OF THE DISSERTATION Computational Genetic Approaches for Understanding the Genetic Basis of Complex Traits by Eun Yong Kang Doctor of Philosophy in Computer Science University of California, Los Angeles, 2013 Professor Eleazar Eskin, Chair Recent advances in genotyping and sequencing technology have enabled researchers to collect an enormous amount of high-dimensional genotype data. These large scale genomic data provide unprecedented opportunity for researchers to study and analyze the genetic factors of human complex traits. One of the major challenges in analyzing these high-throughput genomic data is requirements for effective and efficient compu- tational methodologies. In this thesis, I introduce several methodologies for analyzing these genomic data which facilitates our understanding of the genetic basis of complex human traits. First, I introduce a method for inferring biological networks from high- throughput data containing both genetic variation information and gene expression profiles from genetically distinct strains of an organism. For this problem, I use causal inference techniques to infer the presence or absence of causal relationships between yeast gene expressions in the framework of graphical causal models.
    [Show full text]
  • An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression Phenotypea Susceptibility Locus for Broad Depression Phenotype
    Author’s Accepted Manuscript An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression PhenotypeA Susceptibility Locus for Broad Depression Phenotype Nese Direk, Stephanie Williams, Jennifer A. Smith, Stephan Ripke, Tracy Air, Azmeraw T. Amare, Najaf Amin, Bernhard T. Baune, David A. Bennett, www.elsevier.com/locate/journal Douglas H.R. Blackwood, Dorret Boomsma, Gerome Breen, Henriette N. Buttenschøn, Enda M. Byrne, Anders D. Børglum, Enrique Castelao, Sven Cichon, Toni-Kim Clarke, Marilyn C. Cornelis, Udo Dannlowski, Philip L. De Jager, Ayse Demirkan, Enrico Domenici, Cornelia M. van Duijn, Erin C. Dunn, Johan G. Eriksson, Tonu Esko, Jessica D. Faul, Luigi Ferrucci, Myriam Fornage, Eco de Geus, Michael Gill, Scott D. Gordon, Hans Jörgen Grabe, Gerard van Grootheest, Steven P. Hamilton, Catharina A. Hartman, Andrew C. Heath, Karin Hek, Albert Hofman, Georg Homuth, Carsten Horn, Jouke Jan Hottenga, Sharon L.R. Kardia, Stefan Kloiber, Karestan Koenen, Zoltán Kutalik, Karl-Heinz Ladwig, Jari Lahti, Douglas F. Levinson, Cathryn M. Lewis, Glyn Lewis, Qingqin S. Li, David J. Llewellyn, Susanne Lucae, Kathryn L. Lunetta, Donald J. MacIntyre, Pamela Madden, Nicholas G. Martin, Andrew M. McIntosh, Andres Metspalu, Yuri Milaneschi, Grant W. Montgomery, Ole Mors, Thomas H. Mosley, Joanne M. Murabito, Bertram Müller-Myhsok, Markus M. Nöthen, Dale R. Nyholt, Michael C. O’Donovan, Brenda W. Penninx, Michele L. Pergadia, Roy Perlis, James B. Potash, Martin Preisig, Shaun M. Purcell, Jorge A. Quiroz, Katri Räikkönen, John P. Rice, Marcella Rietschel, Margarita Rivera, Thomas G. Schulze, Jianxin Shi, Stanley Shyn, Grant C. Sinnamon, Johannes H. Smit, Jordan W.
    [Show full text]
  • Ollikainen, Miina Eliisa 10.01.2019 Tel. +358 50 415 1276 Email Miina
    Ollikainen, Miina Eliisa CV 10.01.2019 Tel. +358 50 415 1276 Email [email protected] Webpage http://epigenetics.helsinki.fi/ https://www.fimm.fi/en/research/groups/ollikainen Academic education and degrees 2013 Title of Docent in Epigenetics, University of Helsinki (UH), Finland 2007 Doctor of Philosophy (Medical Genetics), UH, Finland 2002 Master of Science (Genetics), UH, Finland Linguistic skills Finnish Mother tongue English Proficient user Current position Academy Research Fellow, Group Leader, Epigenetics of Complex Diseases and traits, Sept 2016- Place of work: Institute for Molecular Medicine Finland, FIMM, UH, Finland Research career phase: Established researcher, full time post My current research group includes Senior Researcher Milla Kibble (expert in applied mathematics), Postdoctoral researchers Emma Cazaly (PhD in molecular medicine), and Maheswary Muniandy (PhD in bioinformatics), and two full-time PhD students; Sailalitha Bollepalli (MSc in bioinformatics) and Yu Fu (MSc in translational medicine). My group also has a part-time biomedical laboratory scientist Ms Mia Urjansson who is responsible for sample collection and preparation, and assisting in the laboratory. Previous posts and work experience 2013- Group Leader, Department of Public Health, UH, Finland 2010 –2013 Junior Group Leader, Academy Postdoctoral Research Fellow, UH, Finland 2007 –2010 Postdoctoral Fellow, Developmental Epigenetics Research, Murdoch Children’s Research Institute, And University of Melbourne, Australia 2002 –2007 Graduate student, Department of Medical Genetics, UH, Finland 2000 –2001 Research assistant, Department of Biosciences, UH, Finland 1999 Undergraduate student, Folkhälsan Research Institute, Department of Medical Genetics, UH, Finland Career break: Maternity leave from 23rd of November 2013 until 31st of December 2014.
    [Show full text]
  • Dose Response of the 16P11.2 Distal Copy Number Variant on Intracranial Volume and Basal Ganglia
    Molecular Psychiatry (2020) 25:584–602 https://doi.org/10.1038/s41380-018-0118-1 ARTICLE Corrected: Correction Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia Ida E Sønderby et al. Received: 12 February 2018 / Revised: 2 May 2018 / Accepted: 25 May 2018 / Published online: 3 October 2018 © The Author(s) 2018. This article is published with open access Abstract Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes of 12 16p11.2 distal deletion and 12 duplication carriers to 6882 non-carriers from the large-scale brain Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent CNV calling procedures, and standardized FreeSurfer image analysis, we found negative dose-response associations with copy number on intracranial volume and on regional caudate, pallidum and putamen volumes (β = −0.71 to −1.37; P < 0.0005). In an independent sample, consistent results were obtained, with significant effects in the pallidum (β = −0.95, P = 0.0042). The two data sets combined showed fi = −6 −9 1234567890();,: 1234567890();,: signi cant negative dose-response for the accumbens, caudate, pallidum, putamen and ICV (P 0.0032, 8.9 × 10 , 1.7 × 10 , 3.5 × 10−12 and 1.0 × 10−4, respectively). Full scale IQ was lower in both deletion and duplication carriers compared to non- carriers. This is the first brain MRI study of the impact of the 16p11.2 distal CNV, and we demonstrate a specific effect on subcortical brain structures, suggesting a neuropathological pattern underlying the neurodevelopmental syndromes.
    [Show full text]
  • Avera Institute for Human Genetics (AIHG) Studies, Are Key to Science-Driven Innovation in Health Care
    Avera Avera & VU Scientific Committee Institute for A Scientific Committee directs initiatives through the expanded Avera and VU partnership. They are Human Genetics at the leading-edge in transforming medicine because large-scale genotype/phenotype infrastructures, like twin The Avera Institute for Human Genetics (AIHG) studies, are key to science-driven innovation in health care. has a history of excellence and an exciting Distinguished members of the committee include: future in innovative genetics research. As a state-of-the-art human molecular genetics laboratory fully equipped with advanced Gareth Davies, PhD technology, they undertake a wide range Gareth Davies, PhD, Chief Scientific of research projects, including personalized Officer and Scientific Director at AIHG, medicine, biobanking, tumor registries, is a Molecular Geneticist with an and behavioral and cancer genetic studies. interest in the genetics of complex By advancing science through numerous traits including behavioral, neuropsychiatric partnerships – both nationally and internationally and developmental disorders. Since 2007, – AIHG is poised to translate this knowledge Davies has concentrated his research on to improve the care provided to Avera patients the molecular genetic analysis of twins and communities. as part of a National Institutes of Health-funded collaboration with the Since 2009, the AIHG has partnered with the NTR. He has extensive experience in world’s leading twin register, the Netherlands coordinating this international partnership Twin Register (NTR) at Vrije Universiteit (VU). and creating a strong infrastructure to With the launch of the Avera Twin Register, support this and future large-scale projects. they now collect and analyze DNA from twins In addition, Davies directs studies in throughout the Midwest and the Netherlands cancer and pharmacogenomics.
    [Show full text]
  • Department of Psychology 118 Haggar Hall Notre Dame in 46556 [email protected]
    01/10/2016 Curriculum Vitae Gitta Lubke Mailing Address University of Notre Dame Department of Psychology 118 Haggar Hall Notre Dame IN 46556 [email protected] Higher Education 1997-2002 PhD, Psychometrics, VU University Amsterdam, The Netherlands 1993-1997 Undergraduate Education & MA (cum laude), University of Amsterdam, The Netherlands Positions 2008-present Associate Professor, Department of Psychology, University of Notre Dame 2010-present Visiting Professor, Biological Psychology, VU University Amsterdam 2004-2008 John Cardinal O'Hara, C.S.C. Assistant Professor, Department of Psychology, University of Notre Dame 2003-2004 Assistant Professor, Department of Psychiatry, VIPBG, Virginia Commonwealth University 2001-2003 Research Associate, Graduate School of Education & Information Studies, UCLA, Supervisor: Bengt Muthén Honors and Awards 2009 Tanaka Award, most outstanding paper published in Multivariate Behavioral Research in 2008 2007 Cattell Award, Outstanding Early Career Contributions to Multivariate Psychology, Society of Multivariate Experimental Psychology Publications Miller PJ, Lubke GH, McArtor DB, Bergeman CS (submitted). Finding structure in data: A data mining alternative to multivariate multiple regression. GL- 1 01/10/2016 McArtor DB, Lubke GH (submitted). Extending multivariate distance matrix regression with an effect size measure and the distribution of the test statistic Nivard MG, Middeldorp CM, Lubke GH, Hottenga JJ, Abdellaoui A, Boomsma DI, Dolan CV (submitted). Detection of gene –environment interaction in pedigree data using genome-wide genotypes. Nivard MG, Lubke GH, Dolan CV, Evans DM, St Pourcain B, Munafò MR, Middeldorp CM. (submitted) Joint developmental trajectories of internalizing and externalizing disorders between childhood and adolescence. Laurin C, Walters R, Boomsma DI, Lubke GH (submitted). The use of vector bootstrapping to improve variable selection precision in Lasso models.
    [Show full text]
  • Patrick Miller
    [email protected] Patrick Miller Education University of Notre Dame Ph.D. Quantitative Psychology (2017) Advisor: Dr. Gitta Lubke NSF Graduate Research Fellowship 2013-2016 Presidential Fellowship, University of Notre Dame 2012 - 2017 Dean's Fellowship, University of Notre Dame 2012 - 2017 University of Notre Dame M.S. Applied Computational & Mathematical Statistics 2015 Advisor: Dr. Fang Liu University of Kansas B.S. Cognitive Psychology with distinction, Honors in Psychology 2012 Minor: Social and Behavioral Sciences Methodology Honors Thesis: \Developing simsem: Simplifying Monte Carlo Simulation with Missing Data" Advisor: Dr. Todd Little Publications Miller P.J., Lubke G.H, McArtor D.B., Bergeman C.S. (Submitted) Finding structure in data using multivariate tree boosting. Psychological Methods. Lubke, G. H., Miller, P. J., Verhulst, B., Bartels, M., Van Beijsterveldt, T., Willemsen, G., , & Middeldorp, C. M. (2015). A powerful phenotype for gene-finding studies derived from trajectory analyses of symptoms of anxiety and depression between age 7 and 18 American Journal of Medical Genetics: Neuropsychiatric Genetics Part B. Lubke, G. H., & Miller, P. J. (2014). Does nature have joints worth carving? A discussion of taxometrics, model-based clustering and latent variable mixture modeling. Psychological medicine, 1-11. Schoemann, A. M., Miller, P. J., Pornprasertmanit, S., & Wu, W. (2014). Using Monte Carlo simulations to determine power and sample size in planned missing data designs. International Journal of Behavioral Development, 38, 471-479. Software Miller, P.J. (2016). Multivariate tree boosting. [R package]. https://github.com/patr1ckm/ mvtboost Pornprasertmanit, S., Miller, P.J., Schoemann, A.M., simsem: Simulated structural equation mod- eling. [R package] http://simsem.org Presentations Miller, P.J.
    [Show full text]