ONFERENCE PROG C

The 13th International Congress on Twin Studies June 4-7, 2010, Seoul, Korea cv mu"'

f6ARtt Seoul c.cio4"J' RA7°J2-- U/1 TOURISM ORGANIZATION FRIDAY (JUNE 4)

18:30 -21:00 ICTS Welcome Reception (Regency Room)

SATURDAY (JUNE 5)

7:30 - 8:15 Breakfast (Regency Room)

Symposium : Genetics of high cognitive abilities Regency Room 815 - 9:45 Organizer: Robert Plomin Robert Plomin & Claire M. A. Haworth 8:15

Genetics of high cognitive abilities : An overview John Hewitt, Angela Brant, Robin Corley, Sally Wadsworth & John DeFries 8:30 A closer look at the developmental etiology of high IQ Matt McGue, Robert M. Kirkpatrick, Michael Miller, & William G. Iacono 8:45 The University of Minnesota Initiative on the Genetics of High Cognitive Ability Allan McRae, Margie Wright, Narelle Hansell, Peter Visscher, Grant Montgomery, & Nicholas G. Martin 9:00 Is high cognitive ability associated with a lower genomic burden of copy number variants?

Dorret I. Boomsma, Catherina E.M. van Beijsterveldt, Inge van Soelen , Sanja Franio, Conor V. Dolan, Denny Borsboom,& M. Bartels 9:15 Genetic analysis of longitudinally measured IQ, educational attainment and educational level in Dutch twin-sib samples

Paper Session : Twin studies of personality & psychological wellbeing Namsan Ill 8:15 - 9:45 Chair: Corrado Fagnani Christian Kandler, Wiebke Bleidorn, & Rainer Riemann 8:15 Sources of cumulative continuity in personality: A longitudinal multiple-rater twin study Veselka, L., Schermer, J.A., Martin, R. A., & Vernon, P.A. 8:30 The heritability of general factor of personality extracted in four different datasets Antonella Gigantesco, Corrado Fagnani, Guido Alessandri, Emanuela Medda, 8:45 Emanuele Tarolla, & Maria Antonietta Stazi

An Italian twin study on psychological well-being in young adulthood Meike Bartels, Gonneke, A.H.M. Willemsen, Niels van der Aa, Toos, C.E.M. 9:00 van Beijsterveldt, & Dorret I. Boomsma

1 Robert Lyle, Kristina Gervin, Gregor Gilfillan, Hanne E. Akselsen, Martin Subjective wellbeing and religion: Investigating effects of gene by environment 10:45 Hamer-0, Rune Moe, Hakon Gjessing, Jennifer Harris, & Dag E. Undlien interaction Christian Kandler, Wiebke Bleidorn, & Rainer Riemann Studying the extent and function of epigenetic variation in twins 9:15 Jennifer R. Harris, Kristina Gervin, Gregor Gilfillan, Hanne E. Akselsen, Martin Life events as environmental states and genetic traits and the role of 11:00 Hannero, Rune Moe, Hakon Gjessing, Dag E. Undlien, & Robert Lyle personality Sources of epigenetic variation in the MHC Emma Dempster, Ruth Pidsley, Leo Schalkwyk, Timothea Toulopoulou, Marco 11:15 Picchioni, Eugenia Kravariti, Robin Murray, & Jonathan Mill e ession : Comparison of natural vs. ART twin pregnancy Namsan V Epigenetic profiling in monozygotic twins discordant for major psychosis. 8:15 9:45 outcome - Chloe Chung Yi Wong, Avshalom Caspi, Benjamin Williams, Ian W. Craig, Chair: Nils Lambalk Renate Houts, Antony Ambler, Terrie E. Moffitt, & Jonathan Mill 11:30 Dorret Boomsma Methylomic profiling in discordant MZ twins: applications to psychiatric 8:15 phenotypes' Comparison of Natural and induced DZ twins in the Dutch Twin Registry: A developmental study Anja Pinborg 8:30 Symposium Vanishing twins in IVF 0:15-11:4 Genetics of Tobacco Use and Nicotine Dependence Namsan Ill Lambalk, C.B., Vink J, Van der Stroom E., & Boomsma, D.I Organizer: Tellervo Korhonen 8:45 Nationwide comparison of perinatal outcome of induced versus natural twins Nicholas G. Martin 10:15 in the Netherlands 2000-2008 A genomewide association study of nicotine and alcohol dependence in Michele Hansen, Lyn Colvin, Beverly Petterson, Jennifer J. Kurinczuk , Australian and Dutch Populations Nicholas de Klerk , & Carol Bower Jingchun Chen, Kenneth S Kendler, & Xiangning Chen 9:00 Kia Jackson, Twins born following assisted reproductive technology: perinatal outcome and 10:30 1 with nicotine admission to hospital Neuregulin association dependence Finn Rasmussen, Karin Modig Wennerstad , Karri Silventoinen, Per Tynelius, Lars Bergman, & Jaakko Kaprio 9:45- 10:15 Coffee Break 10:45 Intelligence, smoking habits and nicotine dependence among Swedish male twin pairs. Symposium: Tellervo Korhonen 11:00 Epigenetic mechanisms uncovered: novel uses of Regency Room Cigarette smoking / nicotine dependence and depression: Mechanisms of co- 10:15-11:45 twins occurrence . Kaisu Keskitalo-Vuokko, Tellervo Korhonen, &Jaakko Kaprio - Organ! . . , zalaillailialliiiiiiillariliMik 11:15 Jordana T. Bell, Craig L. Hyde , Juliette M. Harris , Graham J. Brock , Frances Gene-environment interactions between depressive symptoms and smoking , , Burgess , Sally John , & Tim Spector 10:15 M.K. Williams Wang Jun Gillian quantity

/ . 0 Hermine Maes ,dl.,, Twin meth lation differences at the seuence level i J.M. Craig, R. Andronikos, M. 011ikainen, E.J. Joo, N. Carson, X Li, B Genetic epidemiology of cigarette and snus use in adult twins Weinrich, L. Gordon, R. Morley, J Galati, K Smith, J. Carlin, G. Smyth, 10:30 & R. Saffery Plenary Lecture Epigenetic studies of a newborn twin cohort: insights into prenatal development 11:45-12:15 Robert Plomin: Behavioral genetics in the era of Regency Room molecular genetics: Learning abilities and disabilities as examples

- 2 - 3 14:30 Pekka Santtila, Ada Johansson, Bettina von der Pahlen, & N. Kenneth Sandnabba 10:15-12:15 COMBO Organizer:Kimberley Weatherall Namsan V 10:15 Kimberley Weatherall The dopamine transporter gene (DAT1) polymorphism moderates the effects of alcohol use on aggressive behaviour in men Introduction/Welcome Nancy Segal, & Iris Blandon-Gitlin 10:35 Gail Moore (Canada) 14:45 Suicidal behaviors in twins whose co-twins deaths were suicides and non- National Multiple Births Awareness Day - Multiple Births Canada (MBC) suicides 10:55 Gail Moore (COMBO) " Paper Session: Introduction of new twin registries; updates on International Multiple Births Awareness Day 13:15-14:45 existing registries Namsan III 11:15 Syuichi Ooki M.D. Ph. D. (Japan) Chair: Jack Goldberg Japan's Multiple Birth Association (JAMBA)_ Jahanfar Shayesteh 11:35 Monica Rankin (Australia) 13:15 Establishment of National Malaysian Twin Registry: challenges and Australia Multiple Birth Association (AMBA) opportunities

11:55 Sabine Herbener (Switzerland) Cesar G. Demayo, Astrid L. Sinco, Marites L. Bonachita-Sanguila , & Mark Anthony J. Torres 13:30 Association Jumeaux - Switzerland Twin registry in Mindanao, Philippines: Issues and Concerns Dedra Buchwald, Eric Strachan, Niloo Afari, Corinne Hunt, & Jack Goldberg 12:15-13:15 Lunch (Foyer on the 2nd Fl ) 13:45 Building a Unique U.S. Twin Registry: How I Lost My Drivers License and Founded a Twin Registry Paper Session: Goldberg, Christopher W. Forsberg, Jennifer Sporleder, Gene-environment interactions in alcohol Jack & Nicholas Smith 13:15-14:45 use/dependence and psychopathology Regency Room 14:00 . How did that happen?: Correcting zygosity assignment in air: Kerry Jang the Vietnam Era Twin Registry Kerry L. Jang, Steven Taylor, & Gordon J. G. Asmundson Ordoriana, JR; Rebollo, I; Carrillo, E; Colodro, L; Gonzalez-Javier, F; 13:15 Sanchez-Romera, JF; Perez-Riquelme, F; Perez-Valera, S; & Martinez-Selva, Etiology of Obsessions and Compulsions: A Behavioral-Genetic Analysis JM Sylvana C.C. Robbers, Floor V.A. van Oort, Tinca, J.C. Polderman, Meike 14:15

Bartels, Gitta H. Lubke, Frank C. Verhulst, Dorret I Boomsma, & Anja C. Development of a population-based registry of adult females in Spain: The 13:30 Huizink Murcia Twin Registry Hopper JL, Foley D, de Klerk, & Boadle J Trajectories of attention problems in childhood Angelica Ronald 14:30 Australian Twin Registry - realising the full potential of research involving 13:45 twins to improve the health and wellbeing of all Australians A twin study exploring the association between prenatal and neonatal complications and autistic spectrum disorders ... Eivind Ystrom 14:00 13:15-14:45 COMBO Namsan V The diagnostic stability and heritability of alcohol dependence Danielle Dick Mari Kaihovaara (Finland) 14:15 13:15 The Psychosocial well-being and financial surviving of multiple birth families in Understanding Gene-Environment Interactions in Adolescent Alcohol Use and Finland Externalizing Behavior COMBO Business meeting

-4 5 SUNDAY (JUNE 6)

14:45-15:15 Coffee Break 7:30-8:15 Breakfast

Plenary Lecture Plenary Reviews 8:15-8:45 Young Ki Paik: Global Human Proteome Project and Regency Room Dorret Boomsma: Behavior and psychiatry Disease Biomarker Discovery for the Nicholas G. Martin: Contributions of twin studies towards Personalized 15:15-16:45 Regency Room Medicine elucidating disease etiology Nils Lambalk: The multiple pregnancy; recent highlights Symposium : of obstetrical research. Regency Room Aging in twins: From molecules to appearance 8:45-10:15

Presidential Address Chair: Kaare Christensen Christian Garm, Tinna Stevnsner, Vilhelm Bohr, & Kaare Christensen 8:45 How Twins Saved Psychology, and What Psychology Has 16:45- 17:15 Twin Study on DNA repair efficiency Given in Return and human aging Regency Room Mikael Thinggaard, Jakob Mortensen, & Kaare Christensen 9:00 (Matt McGue) Changes in percieved age and mortality Feldman AL, Eriksson UK, Johansson ALV, Gatz M, Pedersen NL, & Wirdefeldt K 9:15 Risk of Dementia in Twins with Parkinsonian Disorders Paulo Ferreira, Manuela Ferreira, Chris Maher, John Hopper, Rachel Huxley, Cristina Alcantara, & Luci McGrath-Cadell 9:30 What is the research involving twins and low back pain telling us? A systematic review Madsen M, Andersen AM, Christensen K, Andersen PK, & Osier M 9:45 Education and Mortality: Causality or selection? A twin approach

Symposium: The role of psychosocial factors in the genetics of 8:45-9:30 anthropometric measures Namsan III

Chair: Karri Silventoinen Karri Silventoinen 8:45 Genetic regulation of growth in Asian and Caucasian populations Finn Rasmussen, Cecilia Ekeus, Karolina Lindstr, Frank Lindblad, & Anders Hjern 9:00 Preterm birth, social disadvantage, and cognitive competence Gonneke Willemsen, Eco J.C. de Geus, & Dorret I. Boomsma 9:15 Genetics of adult body composition: do socioeconomic circumstances matter?

-6 7 Paper Session Digital quantification of human eye color highlights genetic association of 9:30-10:30 Namsan Ill Twins' Development: Russian twin studies three new loci Chair: Marina Egorova 9:30 Marina Egorova, Nadezda Zyrianova, Oxana Parshikova, & Yulia Chertkova Coffee Break 10:15-10:45 Academic Achievement of Twins and Peculiarities of Shared and Non-shared Environment 9:45 Olga Alexeeva, Marina Egorova, Irina Kozlova, & Svetlana Pyankova Symposium: Epigenetic studies in perinatal twin cohorts Twins and siblings: Differences in IQ? personality relations 10:45-12:00 Regency Room 10:00 Vilenskaya Galina Chair : Richard Saffery J.M. Craig, M. 011ikainen, K.R. Smith, E.J. Joo, H.K Ng, R. Andronikos, B. The study of early development of behavior control in twins Novakovic, N.K. Abdul Aziz, J.C. Carlin, R. Morley, & R. Saffery 10:15 Tsetlin MM 10:45 DNA methylation analysis in multiple tissues from twin pairs at birth reveals The continuity in working memory development from infancy to preschool age: both genetic and in utero environmental/stochastic components to human longitudinal twin study neonatal epigenome establishment. R. Saffery, R. Morley, M. 011ikainen, R. Andronikos, E.J. Joo, J. Carlin, S. Paper session : Healy, T. Vaiano, N. Brooks, G. Mcllroy, A Czajko, & J.M. Craig Genetic studies to identify underlying mechanisms of 11:00 8:45-10:30 complex ocular diseases and their endophenotypes Namsan V The Perinatal Epigenetic Twin Study (PETS) Eric Joo, Lavinia Gordon, Miina 011ikainen, Roberta Andronikos, Alicia Oshlak, Chair : Paul Baird Gordon Smyth, Richard Saffery, & Jeff Craig Christopher J. Hammond, Pirro G. Hysi, Terri L. Young, Alberto Fernandez- 11:15 Medarde, David A. Mackey, Toby Andrew, Abbas M. Solouki, Alex W. Hewitt, Evaluation of epigenetic discordance in umbilical vein endothelial cells from Stuart Macgregor, Johannes R. Vingerling, Yi-Ju Li ,M.Kamran lkram, Lee Yiu newborn MZ twins Fai, Pak C. Sham, Lara Manyes, Angel Porteros, Margarida C. Lopes, Francis B. Novakovic, H.K. Ng, M. 011ikainen, J. Craig, &R. Saffery 8:45 Carbonaro, Samantha J. Fahy, Nicholas G. Martin, Cornelia M. van DOM, Timothy D. Spector, Jugnoo S. Rahi, Eugenio Santos, & Caroline C.W. Klaver 11:30 Dissecting the role of genes and environment in the establishment of the neonatal epigenome: DNA methyl6tion analysis of placental tissue from twin GWAS in the twin eye study -glaucoma or myopia? pregnancies. Mingguang He 9:00 Symposium : from the Chinese twin Eye Study Latest results Twin Studies in China Ruth Hogg 10:45-12:00 Namsan Ill 9:15 Chair : Xialion Wang Macular characteristics in older twins Liming Li, Wenjing Gao, Jun Lv, Weihua Cao, Siyan Zhan, Huiying Yang, & Paul Baird Yonghua Hu 9:30 10:45 Can epigenetics be used to identify genes involved in eye diseases? "The Chinese National Twin Registry: What have we done and where to go?" Maria Schache Mingguang He 9:45 11:00 Copy number variations in myopia Guangzhou Twin Registry and Guangzhou Twin Eye Study - Yi Lu Tao Li, Yi Huang, Xiaowei Zhang, Xiaohong Ma, David Collier, 10:00 & Pak C Sham Common Genetic Variants near the Brittle Cornea Syndrome Locus ZNF469 Influence the Blinding Disease Central Corneal 11:15 Risk Factor Twin Registry in Southwestern China (TRiSC): exploring the effects of genetic Fan Liu , Andreas A. Ankra-Badu, Timothy Wollstein, Pirro G. Hysi, Georgina and environmental factors on mental health wellbeing in children and D. Spector, Daniel Park, Gu Zhu, Mats Larsson, David L. Duffy, Grant W. adolescents 10:15 Montgomery , David A. Mackey, Susan Walsh, Oscar Lao, Albert Hofman, Fernando Rivadeneira, Johannes R. Vingerling, Andre G. Uitterlinden, Nicholas G. Martin, Christopher J. Hammond, & Manfred Kayser

8 9 11:30 Ting Wu, Harold Snieder, Liming Li, Weihua Cao, Siyan Zhan, Jun Lv, Wenjing Gao, Xiaoling Wang, Xiuhua Ding, & Yonghua Hu Symposium : Methodology/statistical issues Genetic and environmental influences on blood pressure and body mass 13:45-14:30 Namsan Ill index in Han Chinese: a twin study Chair: Jacob Hjelmborg Weili Yan, He Sun, Kai Yan, Qian Wang, Lei Dou, Xiaofeng Sun, &Yan Li Jacob Hjelmborg, Torben Martinussen, Mette Gerster, Corrado Fagnani, & 11:45 Jaakko Kaprio. Twin study on low/non-response to HBV vaccination in infants 13:45 Modelling time-va genetic influence. Jian Zhang & Mingguan e 12:00-13:15 Lunch (Namsan II & V; posters displayed in Namsan I) 14:00 Generalized Linear Mixed Model he estimation of heritability in twin study John Hopper Plenary Lecture 14:15 Inference on Causation from Elimination of FAmiliaL CONfounding (Ice 13:15-13:45 Regency Room Tim Spector: Novel uses of twins in the era of molecular Falcon) genetics- examples from epigenetics and gene expression Paper Session: Twin studies of cancer Paper session: 14:30-15:30 Namsan Ill Age-pattern in obesity phenotypes 13:45-15:30 Regency Room Hopper Chair: Kirsten Kyvik Jacob v. B. Hjelmborg, Axel Skytthe, Torben Martinussen, Kaare Christensen, Kirsten 0. Kyvik, & Niels V. Holm Venla S. Laitala 14:30 13:45 Cancer in Danish Twins: Environmental and Genetic Factors Association of midlife obesity and related metabolic disorders with old age Thomas Mack, cognition Songhee Cho, & Ann Hamilton Cassandra Nan, Boliang Guo, Claire Warner, Tom Fowler, Timothy Barrett, 14:45 Clues to genetic susceptibility to breast cancer: of breast cancer Khalid Khan, Dorret Boomsma, Tracy Nelson, Keith Whitfield, Gaston A study concordant twin pairs Beunen, Martine Thomis, Juan Ordonana, Jon Deeks, & Maurice Zeegers 14:00 Fabrice Odefrey; Jennifer Stone; Lyle C. Gurrin; Graham B. Byrnes, Carmel Apicella; Gillian S. Dite; Jennifer N. G. A. Meta-analysis on heritability of BMI in pre-adolescence, young adulthood and Cawson; Graham Giles; Susan Treloar; Dallas R. English; John L. Hopper; & Melissa C. Southey late adulthood 15:00 Leonie H. Bogl, Antti Latvala, Jaakko Kaprio, Ai la Rissanen, & Kirsi H. Pietilainen Common genetic variants associated with breast cancer and mammographic measures that predict 14:15 density disease An investigation into the relationship between soft tissue body composition Gillian S. Dite, Jennifer Stone, & John L. Hopper and bone mineral density in a young adult twin sample Niels van der Aa, Eco J.C. de Geus, Dorret I. Boomsma, & Meike Bartels 15:15 Are genetic and environmental components of variance in mammographic density measures that predict breast cancer risk independent of within-twin 14:30 Genetic influences on individual differences in exercise and sedentary pair differences in body mass index? behavior during adolescence R.N.H. Touwslager, M. Gielen, C. Derom, A.L.M. Mulder, W.J.M. Gerver, L.J. Symposium: Bulmer Session Zimmermann, A.J. Houben, C.D.A. Stehouwer, R. Vlietinck, R.J.F. Loos, 13:45-15:30 Namsan V 14:45 & M.P. Zeegers Chairs: Nils Lambalk & Catherine Derom Catherine Derom Determinants of Infant Growth in Four Age Windows: a Twin Study 13:45 Lise Dubois, & Manon Girard The genesis of multiple gestation

15:00 . Jodie N Painter, Gonneke Willemsen, Dale Nyholt, Chantal Hoekstra, David L Genetic and environmental influences on children's food intake and obesity in i Duffy, Anjali K Henders, Leanne Wallace, Sue Healey, Lisa A Cannon-Albright, a Canadian twin birth cohort 14:00 Mark Skolnick, Nicholas G Martin, Dorret I Boomsma, & Grant W Montgomery Ann Louise Hasselbalch 15:15 Obesity in adulthood: interplay between nature and nurture The genetics of DZ twinning

- 10 - Gonneke Willemsen, Toos van Beijsterveldt, & Dorret I. Boomsma Three-dimensional craniofacial discordant Monozygotic twins with cleft lip and 14:15 Comparing maternal characteristics in MZ and DZ twin mothers: what does it palate: A model for identifying deformations of Cleft

tell us about DZ twinning? Cesar G. Demayo, Astrid L. Sinco, Marites L. Bonachita-Sanguila , Lambalk, C.B., Vink J, Van der Stroom E. & Boomsma D.I & Mark Anthony J. Torres 15:45 14:30 Ovarian ageing and twinning Geometric, morphometric analyses of facial shape in twins E.A.M. Kuijper, J.C.F. Ket, & C.B. Lambalk David Teplica, Louis Keith, & Donald Keith 14:45 16:00 Perinatal endocrinology of twins Extreme similarity of secondary skin structures in the faces of a representative pair of concordant MZ twins Dorthe Grosen, Camilla Bille, Inge Petersen, Jacob Krabbe Pedersen, Axel Skytthe, Jeffrey C Murray, & Kaare Christensen Paper session : 16:15 Obesity and related metabolic diseases 15:30-16:45 Regency Room Twins with oral cleft in Denmark 1934-2004 Chair: Qihua Tan Paper session : A.M.C. Simonis-Bik, D.I. Boomsma, J.M. Dekker, M. Diamant, E.J.C. de Twin pregnancy management and prevention of Geus, L.M. Hart, R.J. Heine, M.H.H. Kramer, J.A. Maassen, A. Mari, adverse Namsan V 15:30 G. Willemsen, & E.M.W. Eekhoff 15:30-16:45 outcome Chair: Nils Lambalk Heritability of post prandial 3-cell function in a Dutch twin family study Hit Kishore Goswami Zhengchang Pang, Shuxia Li, Dongfeng Zhang, Haiping Duan, Torben A Kruse, Kaare Christensen, Kirsten 0 Kyvik, & Qihua Tan 15:30 cytogenetics of abortions and t`" 15:45 Population vanishing twin Independent and common pathway models fitted to Chinese twin data on Ilse Delbaere multiple sub-phenotypes predisposing to metabolic syndrome 15:45 ageing and the delivery of twins Qihua Tan, Shuxia Li, Zhengchang Pang, Dongfeng Zhang, Torben A Kruse, Maternal Lim Kaare Christensen, & Kirsten 0 Kyvik Arianne 16:00 16:00 delivery Cross-population disparity in genetic and environmental effects on Prevention strategies for premature with multiple pregnancy? Facts endophenotypes associated with metabolic syndrome and fiction. Dongfeng Zhang, Shuxia Li, Zhengchang Pang, Torben A Kruse, Kaare Marij Gielen Christensen, Kirsten 0 Kyvik, & Qihua Tan 16:15 16:15 Secular trends in gestational age and birthweight in twins Genome-wide linkage scan for QTL affecting BMI in Chinese twins using high density SNP markers Harold Snieder, Ting Wu, & William F Page 17:00-18:00 Business meeting (refreshments served) Regency Room 16:30 Genetic and environmental influences on blood pressure and body mass index in the NAS-NRC World War II Veteran Twin Registry Inge Petersen, Morten Munk, Frost Nielse, & Kaare Christensen 19:00-21:30 Dinner (Regency Room) 16:45 No evidence of higher 10-year period prevalence of diabetes among 77,335 twins compared with 212,894 singletons from the Danish birth cohorts 1910- 89.

Paper session : Cleft, facial morphology & facial skin in twins 15:30-17:00 Namsan Ill Chair: Louis Keith Reiko Shibazaki-Yorozuya, Yusuke Asama, Fumio Ohkubo, Kouichi 15:30 Kadomatsu, Yuko Kako, Yoshiaki Hosaka, & Koutaro Maki

- 12 - - 13 - MONDAY JUNE 7 The intrauterine environment and cognitive development in young twins.

I.H. Linskens , & J.M.G. van Vugt 7:00-8:15 Breakfast 10:15 Prenatal screening in twins

Symposium : Genetic and environmental variations in human sexual Regency 8:15-9:15 behaviors Room 11:00-1:00 Lunch (Official close of the 13th ICTS)

. , iiiiiiimmiumill11111 Organizer: Andrea Burri Andrea Burri, Lynn Cherkas, & Tim Spector

8:15 Genetic and Environmental Influences on Female Sexual Dysfunctions: Poster Session (SUNDAY June 6) - Namsan I Results of a Genome-wide Association Study in an Unselected UK twin population Posters should be put up on the poster boards at Namsan I before lunch. During the lunch Westerlund Minja, & Pekka Santtila time, authors of the posters should be present. Posters will be displayed throughout Sunday 8:30 until 6:00 pm. Each board has a number which will be matched with the number below. Genetic and environmental influences on sexual socialization Patrick Jern, Pekka Santtila, Lars Westberg, Hasse Walum, Christin T. Maria Manuela Martins Pedersen, Elias Eriksson, & N. Kenneth Sandnabba 1 8:45 Intervene in families with twins The Dopamine Transporter Gene (DAT1) Polymorphism is Associated with Luisa Maria da Costa Andrade, Maria Manuela Ferreira Pereira da Silva Martins, & Premature Ejaculation 2 Maria Julia da Costa Marques Martinho R:Effhiffer, J. Michael Bailey, & Nicholas G. Martin

.._ .-_e--Es-e-C-\ 9:00 s Parenthood in multiple birth, a review of the literature Genetic correlates of orgasm rate in female twins, and implications for Luisa Andrade Maria Manue understanding 'female orgasmic disorder' 3 Famil chane es in twin renancies Paper session : Kumpula Ulla Twin studies of IQ and language development Regency . 9:15-10:15 4 Room Project "Good beginning to parenting multiples" (2009-2011) Chair: Yulia Kovas 5 Yuko Sugiura Yulia Kovas, Sophia J Docherty, & Robert Plomin 9:15 About the Japanese Association of Twin's Mothers ( JATM ) One step forward, two steps back: explaining the slow progress with Chow, Matthew K. Vendlinski, Nicole L. Schmidt, Carol A. Van Hulle, Kathryn understanding the origins of individual differences in mathematics. 6 Oi Kam Lemery-Chalfant, & H. Hill Goldsmith Narelle Hansell, Brendan P Zietsch, Nicholas G. Martin, Damian Birney, Glenda Andrews, David H Shum, Graeme S Halford, & Margaret J Wright Effortful control predicts twin relationship quality from middle childhood to 9:30 Relational Complexity Measures of Cognitive Processing: Heritability and adolescence Patrick Heath, Matthew K. Vendlinski, Nicole L. Schmidt, Kathryn Lemery-Chalfant, Association with IQ &H. Hill Goldsmith William Coventry 7 9:45 Adolescent Twin Relationships: Evidence for change in heritability over time Teacher Effects in Early Literacy Development: Evidence From a Study of Keiko K. Fujisawa, Juko Ando, &Toshikazu Hasegawa Twins Mari Nozaki, 8 The links between sibling relationships in Japanese preschool twins with their Obstetric issues in twin studies adjustment 0:00-10:30 Regency Philipp Barsky, Sergey Malykh, Elena Gindina, &Marina Lobaskova Chair: Room 9 Evangelia E. Antoniou, Tom Fowler, Evert Thiery, Taunton Southwood, Sofie Social-economic status and dimensions of family environment as perceived by 10:00 van Gestel, Nele Jacobs, Jim Van Os, Somasundari Gopalakrishnan, parents of Russian adolescent twins Catherine Derom, & Maurice P. Zeegers

-14- - 15 - 10 Kristiina Heinonen Master Sergey Malykh, Elena Gindina, &Marina Lobaskova 24 The individual differences in temperament in Russian adolescent twins and Different kinds of support for multiple families singletons

Azam Hamidzadeh Johanna Salo , Markus Jokela, Paivi Merjonen , Terho Lehtimaki, 11 & Liisa Keltikangas-Jarvinen Effects of Ll4 Acupressure on labor pain in the first stage of labor 25 I.H. Linskens, & J.M.G. van Vugt Serotonin receptor 2A gene moderates the effect of childhood nurturing environment 12 on social attachment in adulthood Outcome of expectant management in cases of discordant structural fetal anomalies Min Jin Jin,.Young Won Shin, Neul Ha, Sejun Koo, Ki-pyoung Kim, Bora Kim,Jin-ah in multiple pregnancies Yoo, Ok-jung Jo, Myoung Ho Hyun & Yoon-Mi Hur Han-na Park, Suk-young Kim, Sun-pyo Lee, Sun-a Hwang, Ji-sun Seo, 26 & Seung-ju Jun A bivariate analysis of sociability and prosocial behaviors among South Korean twin 13 children The perinatal outcomes of twin-to-twin transfusion syndrome based on clinical stage: Shinji Yamagata, Chizuru Shikishima, &Juko Ando for 10 years' experiences (2000-2009) 27 Hit Kishore Goswami Parental disciplines exert shared-environmental influences on adolescents' moral 14 behaviors - A Japanese twin study. Some triplets offer cotwin control study as evidence Eun-Yung Koh, &Young Lee Shuenn-Dyh Chang, & Yao-Lung Chang 28 15 The effects of twin infants' temperament on maternal parenting stress: Comparison Chromosomal polymorphic variations help determine zygosity in same sex twin with singleton infants

pregnancies Daisuke , & Okuda . Okuda Enji, Horii Aiko Jahanfar Shayesteh 29 16 Differences in sport performance and personality traits between a pair of monozygotic Fetal Origin Hypothesis and Reproductive Health of Twins twins Yao-Lung Chang, Chuan-Chi Kao, &Tzu-Hao Wang Eric Strachan, Misty Saracino, Jack Goldberg, Dedra Buchwald, & Anna Wald 30 17 Placental genes express level in intrauterine Growth Restriction fetus: using Preliminary results from a twin study of personality, stress, and HSV-1 infection monozygotic twin model: implication for the placental role of 'fetal programming' for Sanja Frania, Marijke G.E. Frantsen, Toos C.E.M. van Beijsterveldt, & Dorret I. adult disease. Boomsma Jahanfar Shayesteh 31 18 Examining the possible relationship between children's IQ and proximity of parental Opposite Sex Twins and Its Effect on Reproductive Health and Reproductive birth place Behavior Keiko K. Fujisawa, Tessei Kobayashi, & Juko Ando Yoshi Yokoyama, Masako Sugimoto, Hiroshi Kurokawa, Karri Silventoinen, Janne 32 19 Pitkaniemi, & Jaakko Kaprio Early lexical development in Japanese-speaking 12-, 18-, and 24-month-old twins Corrado Fagnani, Steen Fibiger, Axel Skytthe, &Jacob v. B. Hjelmborg Growth Charts of Length and Height from Birth to Six Years of Age in Japanese 33 Triplets Heritability and genetic relationship of childhood speech disorders, stuttering, and Nicholas de Klerk, Phyllis Alessandri, & Janice Hansen cluttering, based on self -resorted data from adult twins 20 Mengel-From J, Petersen I, Thinggaard M, Christiansen L, & Christensen K Birthweight, zygosity, sex and gestation in Western Australian twins 34 Syuichi Ooki, Skewed X-inactivation and survival - a 13 year follow-up study of elderly twins and 21 Impact of the increasing number of multiple births on the low birthweight and preterm Maria Antonietta Stazi, Rodolfo Cotichini, Corrado Fagnani, Luigina Ferrigno, delivery during the last thirty years in Japan: Vital statistics, 1975-2008 35 aurizio Ferri, Antonia Gregorio, Chiara Rinaldi, Sally L. Williams, &Giovanni Maraini Yoko Imaizumi 22 Genetic effects on age-related cataract: evidence from an Italian twin study Recent and long trends of multiple births in Japan, 1980-2008: Rates for multiple Tomoyo Ohno, Soshiro Ogata, Kazuo Hayakawa, & Reiko Nishihara births, stillbirths, erinatal mortalit and birth weight under 2500 36 Veselka, L., Schermer, J.A., Martin, R. A., & Vernon, P.A. Lifestyle Factors Affecting the Decline of Higher-level Functional Capacity in Elderly 23 Twins A behavioral genetic study of humor styles and mental toughness Teresa Lee, Miriam Mosing, Margaret J. Wright, Julian N. Trollor, Julie D. Henry, Geels, L.M., Vink, J.M., Van Beek, J.H.D.A., Bartels, M., de Moor, M.H.M. , Andrea Lammel, David Ames,Nicholas G. Martin, & Perminder S. Sachdev Willemsen, G., & Boomsma, D.I. 37 Genetic and environmental influences on measures of processing speed: The older 50 Alcoholic beverage preference in relation to quantity of alcohol consumption and Australian twins study general health Susanne Knudsen Karin J.H. Verweij, Brendan P. Zietsch, Michael T. Lynskey, Sarah E. Medland, 38 Michael C. Neale, Arpana Agrawal, Nicholas G. Martin, Dorret I. Boomsma, & How to create a reliable biobank? Experiences from the Danish Twin Registry. 51 Jacqueline M. Vink Lars Hvidberg 39 Genetic etiology of cannabis use initiation and problematic use: a meta-analysis of How to provide IT support for a reliable biobank - experiences from the Danish Twin twin studies and a genome-wide association study Registry. Jacquelyn L. Meyers, Ulla Broms, Alexis C. Edwards, Jaakko Kaprio, Jack Goldberg, Carolyn Noonan, Eric Strachan, Niloo Afari, & Dedra Buchwald & Danielle M. Dick 40 52 Updating zygosity in the University of Washington twin registry Parental Education Level Moderates the Importance of Genetic and Environmental Morley R, Raj S, &Hopper J influences on Adolescent Smoking 41 Shawn J. Latendresse, Richard J. Rose, Richard J. Viken, Lea Pulkkinen, Jaakko MATCH (mothers and twin children), A prenatally recruited volunteer register of twins 53 Kaprio & Danielle M. Dick

Sonia Brescianini ,Silvia Giampietro , Rodolfo Cotichini, Corrado Fagnani, Renato

Lucchini , & Mario De Curtis Re-examining the dimensionality of parental socialization: A multivariate genetic 42 analysis Genetic and environmental components of postnatal weight gain in the first month of Reiko Nishihara, Fujio Inui, Kenji Kato, Rie Tomizawa, Yang Ping Cai, & Kazuo life Hayakawa Lorenza Nistico, Alfonso Galderisi, Rodolfo Cotichini, Corrado Fagnani, Virgilia 54 43 Toccaceli, M. Antonietta Stazi, & Dario lafusco Genetic contribution to the relationship between social role function and depressive symptoms in elderly twins Heritability of type 1 diabetes mellitus in a cohort of Italian twins Rie Tomizawa

M. Vamosi , B. L. Heitmann , M. Thinggaard , & K. 0. Kyvik 55 44 Lifestyle and Environmental Factors Affecting Intra-pair Differences of Depressive Perception of being bullied and parental care and neglect during childhood and the Symptoms liAged Identical Twins development of adult obesity: a co-twin control study Ting Xu, &Raymond C. K. Chan Emanuela Medda, Corrado Fagnani, Rodolfo Cotichini, Lorenza Nistico, Miriam 56

Salemi , David Laszlo Tarnoki, Adam Domonkos Tarnoki, Fabrizio Fanelli, Claudio Heritabilit of neurological soft signs: A preliminary study in Chinese healthy twins 45 Baracchini, Zsolt Garami, & Maria Antonietta Stazi Paivi Merjonen, Markus Jokela, Johanna Salo, Terho Lehtimaki, &Liisa Keltikangas- Jarvinen Heritability of carotid intima-media thickness and arterial stiffness: preliminary results 57 from an Italian twin study The association between breastfeeding and child's later adult depression: The role of Xiaoling Wang, Haidong Zhu, Huidong Shi, Frank Treiber, & Harold Snieder estroen recetor ene 01 morhism 46 Alexndra P. Belova , &Sergey B. Malykh Genome wide methylation analysis in monozygotic twins discordant for essential 58 hypertension Depression in adolescents: twin study on Russian adolescent sample Christine Dalgaard, Ann Louise Hasselbalch, Thorkild IA Sorensen, &Kirsten Ohm Elena D. Gindina, Sergei B. Malykh, &Marina M. Lobaskova Kyvik 59 47 Emotional and behavioral problems in Russian twins Do fruit and vegetables modify the association between obesity and inflammatory risk Xinying Li markers of cardiovascular disease? A study in a healthy Danish twin population. 60 Mingguang He Beijing Twin Project on Mental Health Problems among Chinese Adolescents 48 Ki-pyoung Kim, Bora Kim, Jin-ah Yoo , Young-won Shin, Min-jin Jin, Heritability of blood pressure and its longitudinal changes in child and adolescent Sejun Koo, Ok-jung Jo, Neul Ha, Myoung-Ho Hyun & Yoon-Mi Hur Chinese twins 61 Van Beek, J.H.D.A.,Vink, J.M., de Moor, M.H.M., Bartels, M., Geels, L.M., Willemsen, Emotionality as genetic and environmental risk factors in hyperactivity problems in 49 G., & Boomsma, D.I. South Korean children

Genetic Factors in Alcoholic Beverage Preference in Dutch Twins 62 Okjung Jo Sejun Koo' Bora Kim Kipyoung Kim, Jinah Yoo', Neul Ha, Minjin Jin, Kenji Kato, Fujio lnui, & Kazuo Hayakawa Youngwon, Shin & Yoon-Mi Hur 75 The Twin Nurses Project: A Web-Based Cohort Study of Work-style and Lifestyle of Changes of genetic and environmental influences on emotional problems during Japanese Adults childhood and early adolescence in South Korean twins Tornwall Outi, Dinnella Caterina, Keskitalo-Vuokko Kaisu, Kaprio Jaakko, Perola Neul Ha, Min Jin Jin, Sejun Koo, Ok-jung Jo, Bora Kim, Ki-pyoung Kim, Jin-ah Yoo, Markus, Monteleone Erminio. & Tuorila Hely 63 Young Won Shin, Myoung- Ho Hyun & Yoon-Mi Hur 76 Twin Study on Salivary Protein Interactions in the Perception of Astringency Genetic and environmental covariations between Emotional Problems and Conduct Viktor Mueller, Andrey P. Anokhin, & Ulman Lindenberger Problems in South Korean twin children 77

Gagne, Jeffrey R , Vendlinski, Matthew K , Lemery-Chalfant , K., & Goldsmith H. H. Heritability of Neural Synchrony and Causal Networks associated with response 64 inhibition in a Go/No-Go Task Parent and laboratory-assessed inhibitory control and related behavior problems at 7- Sarah E. Medland 8 years of age 78 Kee Jeong Kim GWAS for finger ridge count 65 Nancy L. Segal, &Iris Blandon -Gitlin The Genetic and Environmental Contributions to the Co-occurring Internalizing and 79 Externalizing Behaviors: A longitudinal Twin Study Monozygotic twins switched at birth: Issues and findings from the recent Canary Anouk den Braber, Dennis van 't Ent, Daisy van Minde, Danielle C. Cath, Dorret I. Islands case Boomsma, & Eco J.C. de Geus Daniel F. Schmidt, & John L. Hopper 66 80 Functional MRI study in monozygotic twins concordant and discordant for obsessive- Akaike Information Criterion is not appropriate for identifying the 'true' model - compulsive symptoms Bayesian Information Criterion is preferable Alexis C. Edwards, Jaakko Kaprio, Richard J. Rose, &Danielle M. Dick 67 Depressive symptoms and alcohol use are genetically and environmentally correlated across adolescence . Mark Anthony Torres 68 Heritabilit of eatin. behavior in selected Phili. sine ethnic 'roues David Champion, Carla Flynn, Amelia Taylor, &Tiina Jaaniste 69 Growing pains shares genetic determinants with the restless legs syndrome Lannie Ligthart, Niels van der Aa, Meike Bartels, & Dorret I. Boomsma, 70 Prevalence and heritability of early-onset migraine Corrado Fagnani, Valeria Patriarca, Luana Penna, Cristina D'Ippolito, Giovanni Di Giovambattista, Sonia Brescianini, & Maria Antonietta Stazi 71 Shared genetic effects between parent-reported asthma and wheezing in young Italian twins Hukkinen M., Kaprio, J., Broms U., Viljanen A., Kotz D., Rantanen, T., & Korhonen T 72 Heritability of lung function: A twin study among never-smoking elderly women Miriam Mosing, Karin J.H. Verweij, Sarah E. Medland, Scott D. Gordon, Margaret J. 73 Wright, Dale R. Nyholt, Grant W. Montgomery, & Nicholas G. Martin

Genome-wide association study on self-rated health. Ordonana, JR Burt, SA Sanchez-Romera, JF Tornero, MJ Perez-Riquelme, 74 & F Rebollo-Mesa

Heritability of Medical Prescription Compliance in Adult Female Twins

-20- - 21 - PROGRAM SUMMARY Sun 7:30-8:15am Breakfast June 6 8:15-8:45am Plenary Lecture Regency Room Fri 6:30 - 9:00pm Welcome Reception Regency Room Young Ki Paik: Global Human Proteome (1st fl.) June 4 Project and Disease Biomarker Discovery for the Personalized Medicine Sat 7:30-8:15am Breakfast Regency Room 8:45-10:15am Symposium : Regency Room June 5 (1st fl.) Aging in twins: From molecules to appearance 8:15-9:45am Symposium : Regency Room .n. Symposium: Namsan III Genetics of high cognitive abilities (1st 8:45-9:30am The role of psychosocial factors in the 8:15-9:45am Paper Session : Namsan III (2nd genetics of anthropometric measures Twin studies of personality & Paper Session III psychological wellbeing 9:30-10:15am Namsan Twins' Development: Russian twin Paper Session : Namsan V 8:15-9:45am studies Comparison of natural vs. ART twin Paper session : Namsan V pregnancy outcome 8:45-10:15 Genetic studies to identify underlying 9:45-10:15am Coffee Break mechanisms of complex ocular diseases 10:15-11:45am Symposium: Regency Room and their endophenotypes Epigenetic mechanisms uncovered: 10:15-10:45am Coffee Break novel uses of twins _ 10:45- 12:OOam Symposium: Regency Room 10:15-11:45am Symposium : Namsan III Epigenetic studies in perinatal twin (1st fl.) Genetics of Tobacco Use and Nicotine cohorts Dependence 10:45- 12:OOam Symposium : Namsan II1(2nd 10:15-12:15pm COMBO Organizer: Namsan V Twin Studies in China fl.) Kimberley Weatherall _ _ Lunch(posters displayed in Namsan I) 11:45-12:15pm Plenary Lecture (Robert Plomin) Regency Room 12:00-1:15pm Plenary Lecture (Tim Spector) Room (1st 1:15-1:45pm Regency (1St fl.) Behavioral genetics in the era of molecular Novel uses of twins in the era of genetics: Learning abilities and disabilities molecular genetics- examples from as examles epigenetics and gene expression 12:15-1:15pm Lunch 2" Fl. Paper session: Regency Room 1:15-2:45pm Paper Session: Regency Room 1:45-3:30pm (1st Age-pattern in obesity phenotypes Gene-environment interactions in alcohol fl.) Symposium : Namsan III use/dependence and psychopathology 1:45-2:30pm Methodology/statistical issues 1:15-2:45pm Paper Session: Namsan III _ (2nd Paper Session: Namsan III Introduction of new twin registries; 2:30-3:30pm Twin studies of cancer updates on existing registries Symposium: Namsan V 1:15-2:45pm COMBO Namsan V 1:45-3:30pm Bulmer Session 2:45-3:15pm Coffee Break 5:OOpm Paper session : Regency Room 3:15-4:45pm Plenary Reviews Regency Room 3:30- Obesit and related metabolic diseases Dorret Boomsma: Paper session : Namsan III Behavior and psychiatry 3:30-4:45pm Cleft, facial morphology & facial skin in twins Nicholas G. Martin: Paper session : Contributions of twin studies towards 3:30-4:45pm Namsan V Twin pregnancy management and elucidating disease etiology prevention of adverse outcome Nils Lambalk: 5:00- 6:OOpm Business meeting (refreshments served) Regency Room The multiple pregnancy; recent highlights of obstetrical research 6:30-9:00pm Dinner Regency Room 16:45- 17:15pm Presidential Address (Matt McGue) Regency Room

- 22 - - 23 - Mon, June 7 7:30-8:15am Breakfast

8:15-9:15am Symposium : Regency Room Genetic and environmental variations in human sexual behaviors

9:15-10:15am Paper session : Regency & Twin studies of IQ and language 2nd Fl. Foyer development 10:00- Obstetric issues in twin studies Regency Room 10:30am _ 11:00-1:00pm Lunch (Official close of the 13th ICTS)

-24- FUNCTION ROOMS AND BUSINESS & MEETING CENTER ON THE SECOND LEVEL GRAND HYATT SEOUL

N

S w RM6 -`

f1

All

*Informafion 02 799 8156 / infoqkyondhyofteoui

GRAND BALLROOM ON THE LOBBY LEVEL GRAND HYATT SEOUL AN

fricornaton 02.709 9156 /14000..4hY00.0. can