Figure S1. Experimental design and schematic workflow diagram. RSV: respiratory syncytial virus; iTRAQ: isobaric tags for relative and absolute quantification; DEPs: differentially expressed proteins.

2 Figure S2. Protein-protein interaction (PPI) network and identification of Molecular Complex Detection (MCODE) components of the union set differentially expressed proteins (DEPs) from respiratory syncytial virus (RSV) infection vs control. A, PPI network of DEPs from the union set of RSV infection of acute phase and convalescence phase (ALL-DEPs). B, Molecular complex detection (MCODEs) identification in the PPI network.

3 Table S1. Identification of differentially expressed proteins between RSV and healthy control by the iTRAQ technique.

Convalescence phase vs Acute phase vs Control Control N Citable Gene Mass(KDa) Species Name %Cov Peptides Fold CV P value Fold CV P value Accession Name (95) (95%) change change

Immunoglobulin alpha-2 heavy chain OS=Homo sapiens 1 P0DOX2 IGG1 48.934 HUMAN 53.630 76 0.36 0.405 0.010343 0.299 0.263 0.000541 OX=9606 PE=1 SV=2 Apolipoprotein A-IV OS=Homo sapiens OX=9606 2 P06727 APOA4 45.399 HUMAN 85.610 124 0.26 0.261 0.000346 0.340 0.201 0.000299 GN=APOA4 PE=1 SV=3 Keratin, type I cytoskeletal 10 OS=Homo sapiens 3 P13645 KRT10 58.827 HUMAN 23.290 16 0.37 0.155 0.000117 0.360 0.769 0.010179 OX=9606 GN=KRT10 PE=1 SV=6 Apolipoprotein C-I OS=Homo sapiens OX=9606 4 P02654 APOC1 9.332 HUMAN 51.810 17 0.88 0.193 0.167924 0.403 0.241 0.001019 GN=APOC1 PE=1 SV=1 Fibronectin OS=Homo sapiens OX=9606 GN=FN1 PE=1 5 P02751 FN1 262.623 HUMAN 59.560 251 0.47 0.097 0.000052 0.408 0.136 0.000095 SV=4 Immunoglobulin heavy constant gamma 4 OS=Homo 6 P01861 IGHG4 35.940 HUMAN 71.870 142 0.24 0.214 0.000141 0.412 0.099 0.000037 sapiens OX=9606 GN=IGHG4 PE=1 SV=1 Dipeptidyl peptidase 4 OS=Homo sapiens OX=9606 7 P27487 DPP4 88.278 HUMAN 6.789 4 0.44 0.210 0.000893 0.413 0.134 0.000128 GN=DPP4 PE=1 SV=2 Keratin, type II cytoskeletal 2 epidermal OS=Homo 8 P35908 KRT2 65.433 HUMAN 17.530 10 0.50 0.383 0.007028 0.422 0.683 0.013008 sapiens OX=9606 GN=KRT2 PE=1 SV=2 Beta-Ala-His dipeptidase OS=Homo sapiens OX=9606 9 Q96KN2 CNDP1 56.706 HUMAN 27.420 12 0.29 0.062 0.000001 0.452 0.100 0.000071 GN=CNDP1 PE=1 SV=4 Coagulation factor XIII A chain OS=Homo sapiens 10 P00488 F13A1 83.267 HUMAN 17.080 12 0.47 0.245 0.001485 0.457 0.106 0.000077 OX=9606 GN=F13A1 PE=1 SV=4 Alkaline phosphatase, tissue-nonspecific isozyme 11 P05186 ALPL 57.304 HUMAN 6.107 3 0.43 0.331 0.010691 0.460 0.215 0.002192 OS=Homo sapiens OX=9606 GN=ALPL PE=1 SV=4 Zinc-alpha-2-glycoprotein OS=Homo sapiens OX=9606 12 P25311 AZGP1 34.259 HUMAN 57.720 44 0.44 0.154 0.000262 0.463 0.392 0.006060 GN=AZGP1 PE=1 SV=2 Phospholipid transfer protein OS=Homo sapiens 13 P55058 PLTP 54.739 HUMAN 29.210 15 0.69 0.138 0.003898 0.485 0.246 0.004244 OX=9606 GN=PLTP PE=1 SV=1 Prenylcysteine oxidase 1 OS=Homo sapiens OX=9606 14 Q9UHG3 PCYOX1 56.640 HUMAN 20.990 10 0.57 0.043 0.000008 0.522 0.116 0.000220 GN=PCYOX1 PE=1 SV=3 Keratin, type II cytoskeletal 1 OS=Homo sapiens 15 P04264 KRT1 66.039 HUMAN 28.730 24 0.50 0.163 0.000596 0.531 0.424 0.015946 OX=9606 GN=KRT1 PE=1 SV=6 Phosphatidylinositol-glycan-specific phospholipase D 16 P80108 GPLD1 92.336 HUMAN 23.810 20 0.79 0.134 0.012434 0.541 0.136 0.000460 OS=Homo sapiens OX=9606 GN=GPLD1 PE=1 SV=3 Cholesteryl ester transfer protein OS=Homo sapiens 17 P11597 CETP 54.756 HUMAN 13.790 6 0.54 0.453 0.016114 0.562 0.361 0.010559 OX=9606 GN=CETP PE=1 SV=2 Cadherin-13 OS=Homo sapiens OX=9606 GN=CDH13 18 P55290 CDH13 78.286 HUMAN 7.293 4 0.58 0.282 0.006765 0.574 0.230 0.003549 PE=1 SV=1 Serum paraoxonase/arylesterase 1 OS=Homo sapiens 19 P27169 PON1 39.731 HUMAN 70.700 37 0.58 0.380 0.014898 0.576 0.399 0.017719 OX=9606 GN=PON1 PE=1 SV=3 Contactin-1 OS=Homo sapiens OX=9606 GN=CNTN1 20 Q12860 CNTN1 113.319 HUMAN 1.965 2 0.57 0.076 0.000659 0.579 0.065 0.000452 PE=1 SV=1 Tetranectin OS=Homo sapiens OX=9606 GN=CLEC3B 21 P05452 CLEC3B 22.537 HUMAN 68.810 20 0.56 0.124 0.000424 0.583 0.202 0.004111 PE=1 SV=3 Cadherin-5 OS=Homo sapiens OX=9606 GN=CDH5 22 P33151 CDH5 87.528 HUMAN 16.200 13 0.52 0.088 0.000092 0.584 0.169 0.002575 PE=1 SV=5 Ficolin-2 OS=Homo sapiens OX=9606 GN=FCN2 PE=1 23 Q15485 FCN2 34.001 HUMAN 31.310 14 0.47 0.527 0.011592 0.585 0.297 0.008559 SV=2 Hepatocyte growth factor-like protein OS=Homo sapiens 24 P26927 MST1 80.319 HUMAN 6.188 5 0.81 0.056 0.000912 0.591 0.094 0.000226 OX=9606 GN=MST1 PE=1 SV=2 SERPIN Antithrombin-III OS=Homo sapiens OX=9606 25 P01008 52.602 HUMAN 65.950 79 0.52 0.165 0.000935 0.593 0.187 0.003451 C1 GN=SERPINC1 PE=1 SV=1 C-type mannose receptor 2 OS=Homo sapiens OX=9606 26 Q9UBG0 MRC2 166.673 HUMAN 0.879 1 0.69 0.037 0.000285 0.603 0.017 0.000010 GN=MRC2 PE=1 SV=2 Lumican OS=Homo sapiens OX=9606 GN=LUM PE=1 27 P51884 LUM 38.429 HUMAN 49.110 28 0.61 0.058 0.000044 0.604 0.128 0.000899 SV=2 Gelsolin OS=Homo sapiens OX=9606 GN=GSN PE=1 28 P06396 GSN 85.697 HUMAN 50.510 48 0.93 0.102 0.179935 0.615 0.072 0.000108 SV=1 4 Alpha-N-acetylglucosaminidase OS=Homo sapiens 29 P54802 NAGLU 82.265 HUMAN 10.090 5 0.58 0.475 0.082506 0.620 0.143 0.006640 OX=9606 GN=NAGLU PE=1 SV=2 Serum paraoxonase/lactonase 3 OS=Homo sapiens 30 Q15166 PON3 39.607 HUMAN 22.600 8 0.65 0.275 0.013967 0.624 0.292 0.011705 OX=9606 GN=PON3 PE=1 SV=3 Apolipoprotein C-II OS=Homo sapiens OX=9606 31 P02655 APOC2 11.284 HUMAN 71.290 26 0.95 0.156 0.453917 0.626 0.324 0.020157 GN=APOC2 PE=1 SV=1 Cartilage acidic protein 1 OS=Homo sapiens OX=9606 32 Q9NQ79 CRTAC1 71.420 HUMAN 14.980 8 0.73 0.187 0.013723 0.627 0.269 0.010121 GN=CRTAC1 PE=1 SV=2 Kinetochore-associated protein 1 OS=Homo sapiens 33 P50748 KNTC1 250.746 HUMAN 0.996 4 0.73 0.511 0.216387 0.633 0.508 0.130247 OX=9606 GN=KNTC1 PE=1 SV=1 Cartilage oligomeric matrix protein OS=Homo sapiens 34 P49747 COMP 82.860 HUMAN 14.800 9 0.74 0.086 0.001458 0.634 0.124 0.001043 OX=9606 GN=COMP PE=1 SV=2 Xaa-Pro dipeptidase OS=Homo sapiens OX=9606 35 P12955 PEPD 54.548 HUMAN 16.020 6 0.69 0.209 0.010839 0.641 0.105 0.000648 GN=PEPD PE=1 SV=3 Serum amyloid A-4 protein OS=Homo sapiens OX=9606 36 P35542 SAA4 14.747 HUMAN 62.310 27 1.12 0.151 0.162591 0.641 0.124 0.001350 GN=SAA4 PE=1 SV=2 Collagen alpha-1(VI) chain OS=Homo sapiens OX=9606 37 P12109 COL6A1 108.529 HUMAN 5.545 4 0.67 0.328 0.036514 0.645 0.308 0.021851 GN=COL6A1 PE=1 SV=3 Inter-alpha-trypsin inhibitor heavy chain H2 OS=Homo 38 P19823 ITIH2 106.463 HUMAN 49.680 114 0.49 0.270 0.003998 0.647 0.263 0.020374 sapiens OX=9606 GN=ITIH2 PE=1 SV=2 Attractin OS=Homo sapiens OX=9606 GN=ATRN PE=1 39 O75882 ATRN 158.536 HUMAN 13.300 29 0.64 0.114 0.000896 0.653 0.197 0.006522 SV=2 Tenascin-X OS=Homo sapiens OX=9606 GN=TNXB 40 P22105 TNXB 458.386 HUMAN 11.800 31 0.68 0.099 0.000768 0.653 0.096 0.000544 PE=1 SV=5 Immunoglobulin kappa constant OS=Homo sapiens 41 P01834 IGKC 11.765 HUMAN 91.590 126 0.49 0.767 0.040814 0.655 0.305 0.018253 OX=9606 GN=IGKC PE=1 SV=2 Basement membrane-specific heparan sulfate 42 P98160 HSPG2 468.826 HUMAN proteoglycan core protein OS=Homo sapiens OX=9606 1.959 7 0.61 0.082 0.000159 0.667 0.080 0.000342 GN=HSPG2 PE=1 SV=4 Pantetheinase OS=Homo sapiens OX=9606 GN=VNN1 43 O95497 VNN1 57.011 HUMAN 5.068 2 0.64 0.263 0.010749 0.679 0.199 0.008935 PE=1 SV=2 Dopamine beta-hydroxylase OS=Homo sapiens OX=9606 44 P09172 DBH 69.064 HUMAN 8.428 4 0.73 0.054 0.001394 0.685 0.076 0.002076 GN=DBH PE=1 SV=3 Extracellular matrix protein 1 OS=Homo sapiens 45 Q16610 ECM1 60.674 HUMAN 23.150 11 0.76 0.181 0.022288 0.687 0.227 0.013985 OX=9606 GN=ECM1 PE=1 SV=2 Dermatopontin OS=Homo sapiens OX=9606 GN=DPT 46 Q07507 DPT 24.005 HUMAN 5.473 1 0.70 0.116 0.008301 0.693 0.065 0.001452 PE=1 SV=2 Carboxypeptidase B2 OS=Homo sapiens OX=9606 47 Q96IY4 CPB2 48.424 HUMAN 21.990 10 0.84 0.148 0.042691 0.699 0.104 0.001324 GN=CPB2 PE=1 SV=2 A0A0C4D IGKV3D- Immunoglobulin kappa variable 3D-20 OS=Homo sapiens 48 12.515 HUMAN 65.520 38 0.31 0.594 0.014160 0.701 0.314 0.033777 H25 20 OX=9606 GN=IGKV3D-20 PE=3 SV=1 Inter-alpha-trypsin inhibitor heavy chain H1 OS=Homo 49 P19827 ITIH1 101.389 HUMAN 52.800 109 0.43 0.641 0.031151 0.701 0.285 0.035996 sapiens OX=9606 GN=ITIH1 PE=1 SV=3 ICOS ligand OS=Homo sapiens OX=9606 GN=ICOSLG 50 O75144 ICOSLG 33.349 HUMAN 6.623 2 0.73 0.140 0.005359 0.703 0.148 0.004441 PE=1 SV=2 Lymphatic vessel endothelial hyaluronic acid receptor 1 51 Q9Y5Y7 LYVE1 35.213 HUMAN 8.075 2 0.79 0.065 0.001261 0.707 0.049 0.000094 OS=Homo sapiens OX=9606 GN=LYVE1 PE=1 SV=2 Vitamin K-dependent protein C OS=Homo sapiens 52 P04070 PROC 52.071 HUMAN 24.510 12 0.62 0.077 0.000159 0.723 0.174 0.008954 OX=9606 GN=PROC PE=1 SV=1 Integrin beta-1 OS=Homo sapiens OX=9606 GN=ITGB1 53 P05556 ITGB1 88.415 HUMAN 3.759 3 0.87 0.049 0.003079 0.724 0.123 0.005504 PE=1 SV=2 Cadherin-6 OS=Homo sapiens OX=9606 GN=CDH6 54 P55285 CDH6 88.308 HUMAN 1.013 1 0.75 0.072 0.003883 0.727 0.060 0.001790 PE=1 SV=1 Neural cell adhesion molecule 1 OS=Homo sapiens 55 P13591 NCAM1 94.574 HUMAN 15.500 10 0.60 0.319 0.011286 0.730 0.184 0.012325 OX=9606 GN=NCAM1 PE=1 SV=3 Endoplasmic reticulum aminopeptidase 2 OS=Homo 56 Q6P179 ERAP2 110.461 HUMAN 1.042 1 0.75 0.143 0.027262 0.731 0.151 0.023722 sapiens OX=9606 GN=ERAP2 PE=1 SV=2 A0A0C4D Immunoglobulin kappa variable 1-8 OS=Homo sapiens 57 IGKV1-8 12.537 HUMAN 55.650 18 0.83 0.158 0.057110 0.735 0.176 0.016647 H67 OX=9606 GN=IGKV1-8 PE=3 SV=1 Apolipoprotein C-III OS=Homo sapiens OX=9606 58 P02656 APOC3 10.852 HUMAN 77.780 55 1.34 0.201 0.038352 0.735 0.208 0.021184 GN=APOC3 PE=1 SV=1 Plexin-B2 OS=Homo sapiens OX=9606 GN=PLXNB2 59 O15031 PLXNB2 205.126 HUMAN 0.653 1 0.80 0.121 0.030986 0.736 0.075 0.003706 PE=1 SV=3 5 Sex hormone-binding globulin OS=Homo sapiens 60 P04278 SHBG 43.779 HUMAN 54.480 21 0.48 0.102 0.000093 0.741 0.102 0.002610 OX=9606 GN=SHBG PE=1 SV=2 Ecto-ADP-ribosyltransferase 3 OS=Homo sapiens 61 Q13508 ART3 43.923 HUMAN 2.057 1 0.56 0.246 0.016295 0.741 0.154 0.028153 OX=9606 GN=ART3 PE=1 SV=2 A0A075B6 Immunoglobulin lambda variable 2-18 OS=Homo sapiens 62 IGLV2-18 12.412 HUMAN 24.580 3 0.74 0.162 0.012836 0.744 0.211 0.039572 J9 OX=9606 GN=IGLV2-18 PE=3 SV=2 Platelet basic protein OS=Homo sapiens OX=9606 63 P02775 PPBP 13.894 HUMAN 32.810 5 1.18 0.066 0.005632 0.746 0.096 0.002696 GN=PPBP PE=1 SV=3 Histidine-rich glycoprotein OS=Homo sapiens OX=9606 64 P04196 HRG 59.578 HUMAN 45.710 35 0.39 0.165 0.000241 0.748 0.188 0.033787 GN=HRG PE=1 SV=1 CD109 antigen OS=Homo sapiens OX=9606 GN=CD109 65 Q6YHK3 CD109 161.688 HUMAN 5.813 7 0.73 0.195 0.014688 0.752 0.220 0.037320 PE=1 SV=2 Immunoglobulin kappa variable 4-1 OS=Homo sapiens 66 P06312 IGKV4-1 13.380 HUMAN 71.070 22 0.91 0.117 0.122802 0.756 0.289 0.071658 OX=9606 GN=IGKV4-1 PE=1 SV=1 Collagen alpha-3(VI) chain OS=Homo sapiens OX=9606 67 P12111 COL6A3 343.667 HUMAN 4.690 13 0.84 0.137 0.035556 0.757 0.163 0.012848 GN=COL6A3 PE=1 SV=5 A0A0J9YV IGHV7-4- Immunoglobulin heavy variable 7-4-1 OS=Homo sapiens 68 12.849 HUMAN 47.010 16 0.71 0.121 0.003558 0.759 0.256 0.093662 Y3 1 OX=9606 GN=IGHV7-4-1 PE=3 SV=1 Ectonucleotide pyrophosphatase/phosphodiesterase 69 Q13822 ENPP2 98.993 HUMAN family member 2 OS=Homo sapiens OX=9606 6.373 5 0.85 0.342 0.339347 0.762 0.478 0.301669 GN=ENPP2 PE=1 SV=3 UDP-GlcNAc:betaGal beta-1,3-N- 70 Q7Z7M8 B3GNT8 43.395 HUMAN acetylglucosaminyltransferase 8 OS=Homo sapiens 3.778 1 0.82 0.106 0.030076 0.766 0.116 0.018653 OX=9606 GN=B3GNT8 PE=1 SV=1 Endoglin OS=Homo sapiens OX=9606 GN=ENG PE=1 71 P17813 ENG 70.577 HUMAN 1.520 1 0.76 0.277 0.119709 0.767 0.279 0.129353 SV=2 COLEC1 Collectin-10 OS=Homo sapiens OX=9606 GN=COLEC10 72 Q9Y6Z7 30.705 HUMAN 14.800 4 0.82 0.017 0.000180 0.769 0.111 0.017421 0 PE=1 SV=2 Apolipoprotein A-I OS=Homo sapiens OX=9606 73 P02647 APOA1 30.778 HUMAN 89.510 225 0.95 0.088 0.257683 0.771 0.495 0.322920 GN=APOA1 PE=1 SV=1 Target of Nesh-SH3 OS=Homo sapiens OX=9606 74 Q7Z7G0 ABI3BP 118.641 HUMAN 4.930 5 0.83 0.108 0.014868 0.773 0.205 0.034964 GN=ABI3BP PE=1 SV=1 Vasorin OS=Homo sapiens OX=9606 GN=VASN PE=1 75 Q6EMK4 VASN 71.712 HUMAN 8.618 5 0.82 0.139 0.026304 0.777 0.188 0.037148 SV=1 SERPIN Corticosteroid-binding globulin OS=Homo sapiens 76 P08185 45.141 HUMAN 51.600 42 0.56 0.188 0.002445 0.779 0.234 0.063571 A6 OX=9606 GN=SERPINA6 PE=1 SV=1 Biotinidase OS=Homo sapiens OX=9606 GN=BTD PE=1 77 P43251 BTD 61.132 HUMAN 20.260 10 0.69 0.157 0.005687 0.779 0.206 0.034232 SV=2 Phosphatidylcholine-sterol acyltransferase OS=Homo 78 P04180 LCAT 49.578 HUMAN 20.450 9 0.71 0.225 0.021078 0.791 0.153 0.018648 sapiens OX=9606 GN=LCAT PE=1 SV=1 Insulin-like growth factor-binding protein 3 OS=Homo 79 P17936 IGFBP3 31.674 HUMAN 15.810 4 0.96 0.059 0.177808 0.791 0.127 0.016467 sapiens OX=9606 GN=IGFBP3 PE=1 SV=2 Intercellular adhesion molecule 2 OS=Homo sapiens 80 P13598 ICAM2 30.654 HUMAN 18.910 5 0.74 0.056 0.000261 0.794 0.065 0.001278 OX=9606 GN=ICAM2 PE=1 SV=2 Aspartate aminotransferase, cytoplasmic OS=Homo 81 P17174 GOT1 46.247 HUMAN 4.600 2 0.81 0.086 0.015899 0.796 0.075 0.008754 sapiens OX=9606 GN=GOT1 PE=1 SV=3 Hepatocyte growth factor activator OS=Homo sapiens 82 Q04756 HGFAC 70.681 HUMAN 14.050 11 0.86 0.063 0.005375 0.796 0.030 0.000071 OX=9606 GN=HGFAC PE=1 SV=1 Vitamin K-dependent protein Z OS=Homo sapiens 83 P22891 PROZ 44.744 HUMAN 17.750 9 0.81 0.182 0.052279 0.803 0.201 0.059636 OX=9606 GN=PROZ PE=1 SV=2 Cholinesterase OS=Homo sapiens OX=9606 GN=BCHE 84 P06276 BCHE 68.418 HUMAN 26.410 17 0.82 0.117 0.014343 0.805 0.121 0.012623 PE=1 SV=1 ADAMTS ADAMTS-like protein 4 OS=Homo sapiens OX=9606 85 Q6UY14 116.544 HUMAN 4.004 3 0.71 0.104 0.007094 0.806 0.059 0.005347 L4 GN=ADAMTSL4 PE=1 SV=2 Cartilage intermediate layer protein 2 OS=Homo sapiens 86 Q8IUL8 CILP2 126.290 HUMAN 1.817 2 0.80 0.160 0.032786 0.811 0.156 0.037144 OX=9606 GN=CILP2 PE=2 SV=2 Complement C1q subcomponent subunit A OS=Homo 87 P02745 C1QA 26.017 HUMAN 28.570 5 1.83 0.248 0.006114 0.811 0.307 0.164572 sapiens OX=9606 GN=C1QA PE=1 SV=2 Neogenin OS=Homo sapiens OX=9606 GN=NEO1 PE=1 88 Q92859 NEO1 160.015 HUMAN 1.848 3 0.80 0.100 0.006751 0.812 0.063 0.001831 SV=2 Creatine kinase M-type OS=Homo sapiens OX=9606 89 P06732 CKM 43.101 HUMAN 5.249 2 0.90 0.076 0.068856 0.812 0.068 0.008541 GN=CKM PE=1 SV=2 CD166 antigen OS=Homo sapiens OX=9606 GN=ALCAM 90 Q13740 ALCAM 65.102 HUMAN 3.774 2 0.86 0.029 0.001787 0.813 0.039 0.001742 PE=1 SV=2 6 Aminopeptidase N OS=Homo sapiens OX=9606 91 P15144 ANPEP 109.539 HUMAN 14.790 13 0.80 0.152 0.024726 0.821 0.111 0.013918 GN=ANPEP PE=1 SV=4 Tenascin OS=Homo sapiens OX=9606 GN=TNC PE=1 92 P24821 TNC 240.851 HUMAN 7.860 12 1.08 0.252 0.695000 0.822 0.226 0.109044 SV=3 Lipoprotein lipase OS=Homo sapiens OX=9606 GN=LPL 93 P06858 LPL 53.162 HUMAN 3.579 1 1.22 0.540 0.763889 0.831 0.321 0.264575 PE=1 SV=1 COLEC1 Collectin-11 OS=Homo sapiens OX=9606 GN=COLEC11 94 Q9BWP8 28.665 HUMAN 26.940 8 1.02 0.186 0.908927 0.837 0.048 0.001070 1 PE=1 SV=1 Platelet-activating factor acetylhydrolase OS=Homo 95 Q13093 PLA2G7 50.077 HUMAN 3.855 2 0.96 0.205 0.553681 0.838 0.120 0.028705 sapiens OX=9606 GN=PLA2G7 PE=1 SV=1 Cadherin-1 OS=Homo sapiens OX=9606 GN=CDH1 96 P12830 CDH1 97.455 HUMAN 3.401 3 0.85 0.022 0.000069 0.840 0.054 0.001732 PE=1 SV=3 Noelin OS=Homo sapiens OX=9606 GN=OLFM1 PE=1 97 Q99784 OLFM1 55.342 HUMAN 12.370 5 0.98 0.034 0.222066 0.843 0.037 0.000501 SV=4 Protein HEG homolog 1 OS=Homo sapiens OX=9606 98 Q9ULI3 HEG1 147.459 HUMAN 1.303 1 0.80 0.058 0.001051 0.844 0.088 0.011564 GN=HEG1 PE=1 SV=3 Receptor-type tyrosine-protein phosphatase zeta 99 P23471 PTPRZ1 254.585 HUMAN 0.389 1 0.96 0.119 0.458820 0.847 0.128 0.073501 OS=Homo sapiens OX=9606 GN=PTPRZ1 PE=1 SV=4 Cystatin-C OS=Homo sapiens OX=9606 GN=CST3 PE=1 100 P01034 CST3 15.799 HUMAN 30.140 5 1.07 0.061 0.065733 0.847 0.052 0.002001 SV=1 Integrin alpha-2 OS=Homo sapiens OX=9606 GN=ITGA2 101 P17301 ITGA2 129.294 HUMAN 3.133 3 0.94 0.025 0.016246 0.848 0.048 0.006274 PE=1 SV=1 Dermcidin OS=Homo sapiens OX=9606 GN=DCD PE=1 102 P81605 DCD 11.284 HUMAN 10.000 1 0.82 0.045 0.003272 0.850 0.061 0.012862 SV=2 Macrophage colony-stimulating factor 1 receptor 103 P07333 CSF1R 107.983 HUMAN 4.630 6 0.92 0.041 0.008497 0.851 0.076 0.007984 OS=Homo sapiens OX=9606 GN=CSF1R PE=1 SV=2 EGF-containing fibulin-like extracellular matrix protein 1 104 Q12805 EFEMP1 54.640 HUMAN 12.170 6 0.82 0.044 0.000557 0.852 0.035 0.000538 OS=Homo sapiens OX=9606 GN=EFEMP1 PE=1 SV=2 Thrombospondin-4 OS=Homo sapiens OX=9606 105 P35443 THBS4 105.868 HUMAN 7.804 6 0.84 0.133 0.032263 0.853 0.086 0.013564 GN=THBS4 PE=1 SV=2 Periostin OS=Homo sapiens OX=9606 GN=POSTN PE=1 106 Q15063 POSTN 93.313 HUMAN 22.130 13 0.78 0.156 0.017953 0.854 0.098 0.019116 SV=2 Glutamyl aminopeptidase OS=Homo sapiens OX=9606 107 Q07075 ENPEP 109.244 HUMAN 1.254 1 0.87 0.057 0.004636 0.854 0.040 0.000929 GN=ENPEP PE=1 SV=3 Keratin, type I cytoskeletal 16 OS=Homo sapiens 108 P08779 KRT16 51.267 HUMAN 4.651 3 0.85 0.108 0.055117 0.855 0.109 0.060481 OX=9606 GN=KRT16 PE=1 SV=4 72 kDa type IV collagenase OS=Homo sapiens OX=9606 109 P08253 MMP2 73.882 HUMAN 6.364 4 0.96 0.020 0.023365 0.855 0.017 0.000338 GN=MMP2 PE=1 SV=2 Laminin subunit gamma-1 OS=Homo sapiens OX=9606 110 P11047 LAMC1 177.601 HUMAN 0.497 1 0.85 0.223 0.197443 0.856 0.250 0.249536 GN=LAMC1 PE=1 SV=3 N-acetylglucosamine-1-phosphotransferase subunit 111 Q9UJJ9 GNPTG 33.973 HUMAN gamma OS=Homo sapiens OX=9606 GN=GNPTG PE=1 3.279 1 0.92 0.057 0.034083 0.858 0.069 0.006407 SV=1 SERPIN Kallistatin OS=Homo sapiens OX=9606 GN=SERPINA4 112 P29622 48.542 HUMAN 43.090 18 1.42 0.088 0.000969 0.858 0.133 0.052147 A4 PE=1 SV=3 Plexin domain-containing protein 2 OS=Homo sapiens 113 Q6UX71 PLXDC2 59.583 HUMAN 9.263 4 0.83 0.222 0.151826 0.859 0.104 0.034647 OX=9606 GN=PLXDC2 PE=1 SV=1 IgGFc-binding protein OS=Homo sapiens OX=9606 114 Q9Y6R7 FCGBP 572.012 HUMAN 3.145 7 1.10 0.028 0.001674 0.860 0.194 0.168677 GN=FCGBP PE=1 SV=3 Cell adhesion molecule 1 OS=Homo sapiens OX=9606 115 Q9BY67 CADM1 48.509 HUMAN 7.240 2 0.83 0.017 0.000208 0.863 0.023 0.000969 GN=CADM1 PE=1 SV=2 Apolipoprotein F OS=Homo sapiens OX=9606 GN=APOF 116 Q13790 APOF 35.399 HUMAN 8.896 3 0.92 0.088 0.096880 0.863 0.094 0.023653 PE=1 SV=2 Keratinocyte differentiation-associated protein OS=Homo 117 P60985 KRTDAP 11.050 HUMAN 16.160 1 0.89 0.137 0.179328 0.864 0.123 0.091078 sapiens OX=9606 GN=KRTDAP PE=1 SV=1 Immunoglobulin superfamily containing leucine-rich 118 O14498 ISLR 45.997 HUMAN repeat protein OS=Homo sapiens OX=9606 GN=ISLR 3.738 1 1.02 0.057 0.658480 0.868 0.049 0.010082 PE=2 SV=1 Ficolin-3 OS=Homo sapiens OX=9606 GN=FCN3 PE=1 119 O75636 FCN3 32.903 HUMAN 63.550 24 0.49 0.551 0.026648 0.869 0.143 0.085748 SV=2 Sulfhydryl oxidase 1 OS=Homo sapiens OX=9606 120 O00391 QSOX1 82.577 HUMAN 4.016 3 0.93 0.044 0.017050 0.873 0.072 0.013415 GN=QSOX1 PE=1 SV=3 Mimecan OS=Homo sapiens OX=9606 GN=OGN PE=1 121 P20774 OGN 33.922 HUMAN 6.376 2 0.89 0.110 0.053762 0.874 0.069 0.012093 SV=1 7 Collagen alpha-1(II) chain OS=Homo sapiens OX=9606 122 P02458 COL2A1 141.785 HUMAN 7.330 10 1.05 0.072 0.251436 0.874 0.068 0.011036 GN=COL2A1 PE=1 SV=3 Immunoglobulin kappa light chain OS=Homo sapiens 123 P0DOX7 IGK 23.379 HUMAN 64.020 373 0.66 0.272 0.017260 0.876 0.158 0.113808 OX=9606 PE=1 SV=1 Voltage-dependent calcium channel subunit alpha- CACNA2 124 P54289 124.567 HUMAN 2/delta-1 OS=Homo sapiens OX=9606 GN=CACNA2D1 2.992 3 0.85 0.033 0.000338 0.877 0.051 0.004520 D1 PE=1 SV=3 HLA class I histocompatibility antigen, A-3 alpha chain 125 P04439 HLA-A 40.840 HUMAN 23.010 6 1.02 0.043 0.350515 0.878 0.103 0.051564 OS=Homo sapiens OX=9606 GN=HLA-A PE=1 SV=2 Thrombospondin-1 OS=Homo sapiens OX=9606 126 P07996 THBS1 129.382 HUMAN 34.790 50 0.75 0.066 0.000587 0.880 0.109 0.050423 GN=THBS1 PE=1 SV=2 SELENO Selenoprotein P OS=Homo sapiens OX=9606 127 P49908 43.173 HUMAN 12.600 5 0.93 0.166 0.334070 0.884 0.195 0.239430 P GN=SELENOP PE=1 SV=3 Complement C1q subcomponent subunit C OS=Homo 128 P02747 C1QC 25.774 HUMAN 33.060 27 0.99 0.334 0.728920 0.886 0.441 0.323894 sapiens OX=9606 GN=C1QC PE=1 SV=3 Anthrax toxin receptor 1 OS=Homo sapiens OX=9606 129 Q9H6X2 ANTXR1 62.788 HUMAN 2.482 2 1.19 0.049 0.006107 0.888 0.061 0.028950 GN=ANTXR1 PE=1 SV=2 SPARCL SPARC-like protein 1 OS=Homo sapiens OX=9606 130 Q14515 75.207 HUMAN 7.380 4 0.90 0.043 0.005354 0.889 0.038 0.002312 1 GN=SPARCL1 PE=1 SV=2 Collagen alpha-1(I) chain OS=Homo sapiens OX=9606 131 P02452 COL1A1 138.941 HUMAN 10.310 15 0.97 0.080 0.339731 0.893 0.041 0.003070 GN=COL1A1 PE=1 SV=5 Plasma alpha-L-fucosidase OS=Homo sapiens OX=9606 132 Q9BTY2 FUCA2 54.066 HUMAN 7.066 3 1.13 0.227 0.310958 0.893 0.207 0.282789 GN=FUCA2 PE=1 SV=2 Receptor-type tyrosine-protein phosphatase eta 133 Q12913 PTPRJ 145.940 HUMAN 4.562 4 0.89 0.030 0.000835 0.894 0.034 0.001806 OS=Homo sapiens OX=9606 GN=PTPRJ PE=1 SV=3 Amyloid-beta precursor protein OS=Homo sapiens 134 P05067 APP 86.943 HUMAN 4.416 3 0.90 0.209 0.275369 0.896 0.212 0.261395 OX=9606 GN=APP PE=1 SV=3 A disintegrin and metalloproteinase with thrombospondin ADAMTS 135 Q76LX8 153.603 HUMAN motifs 13 OS=Homo sapiens OX=9606 GN=ADAMTS13 4.275 6 0.90 0.041 0.004388 0.896 0.038 0.003036 13 PE=1 SV=1 Cell surface glycoprotein MUC18 OS=Homo sapiens 136 P43121 MCAM 71.607 HUMAN 5.573 4 0.94 0.093 0.212723 0.896 0.075 0.029840 OX=9606 GN=MCAM PE=1 SV=2 Fibulin-1 OS=Homo sapiens OX=9606 GN=FBLN1 PE=1 137 P23142 FBLN1 77.213 HUMAN 19.200 14 0.98 0.124 0.630386 0.896 0.124 0.110644 SV=4 Interleukin-6 receptor subunit beta OS=Homo sapiens 138 P40189 IL6ST 103.536 HUMAN 0.763 1 0.84 0.032 0.001609 0.900 0.050 0.024282 OX=9606 GN=IL6ST PE=1 SV=2 Neural cell adhesion molecule L1-like protein OS=Homo 139 O00533 CHL1 135.071 HUMAN 5.877 7 0.93 0.029 0.005595 0.901 0.030 0.001361 sapiens OX=9606 GN=CHL1 PE=1 SV=4 Collagen alpha-2(V) chain OS=Homo sapiens OX=9606 140 P05997 COL5A2 144.910 HUMAN 4.270 5 0.84 0.087 0.026541 0.905 0.071 0.065636 GN=COL5A2 PE=1 SV=3 A0A0C4D IGKV6- Immunoglobulin kappa variable 6-21 OS=Homo sapiens 141 12.430 HUMAN 35.090 4 0.84 0.088 0.028178 0.905 0.101 0.133254 H24 21 OX=9606 GN=IGKV6-21 PE=3 SV=1 Endoplasmic reticulum chaperone BiP OS=Homo sapiens 142 P11021 HSPA5 72.332 HUMAN 26.300 16 0.82 0.107 0.013748 0.908 0.077 0.046768 OX=9606 GN=HSPA5 PE=1 SV=2 Tyrosine-protein kinase receptor UFO OS=Homo sapiens 143 P30530 AXL 98.336 HUMAN 1.342 1 0.90 0.064 0.021398 0.914 0.021 0.000656 OX=9606 GN=AXL PE=1 SV=4 Protein MMS22-like OS=Homo sapiens OX=9606 144 Q6ZRQ5 MMS22L 142.319 HUMAN 1.207 3 1.07 0.138 0.419803 0.916 0.150 0.288963 GN=MMS22L PE=1 SV=3 Clusterin OS=Homo sapiens OX=9606 GN=CLU PE=1 145 P10909 CLU 52.494 HUMAN 50.560 102 0.60 0.196 0.004046 0.920 0.086 0.082040 SV=1 Calsyntenin-1 OS=Homo sapiens OX=9606 GN=CLSTN1 146 O94985 CLSTN1 109.792 HUMAN 2.854 3 0.87 0.066 0.007830 0.920 0.063 0.040795 PE=1 SV=1 B4GALT Beta-1,4-galactosyltransferase 1 OS=Homo sapiens 147 P15291 43.920 HUMAN 7.035 2 0.94 0.114 0.339551 0.920 0.074 0.105363 1 OX=9606 GN=B4GALT1 PE=1 SV=5 Insulin-like growth factor-binding protein complex acid 148 P35858 IGFALS 66.034 HUMAN labile subunit OS=Homo sapiens OX=9606 GN=IGFALS 32.070 20 0.88 0.187 0.166784 0.923 0.120 0.190079 PE=1 SV=1 Protocadherin-18 OS=Homo sapiens OX=9606 149 Q9HCL0 PCDH18 126.148 HUMAN 2.026 2 1.10 0.088 0.073700 0.923 0.056 0.031431 GN=PCDH18 PE=2 SV=3 Neuropilin-2 OS=Homo sapiens OX=9606 GN=NRP2 150 O60462 NRP2 104.830 HUMAN 2.685 4 0.80 0.121 0.013908 0.926 0.084 0.104305 PE=1 SV=3 IGKV1D- Immunoglobulin kappa variable 1D-16 OS=Homo sapiens 151 P01601 12.730 HUMAN 56.410 36 0.90 0.129 0.112665 0.928 0.129 0.227304 16 OX=9606 GN=IGKV1D-16 PE=3 SV=2 8 Coagulation factor VII OS=Homo sapiens OX=9606 152 P08709 F7 51.594 HUMAN 5.365 2 1.00 0.050 0.874636 0.929 0.087 0.128881 GN=F7 PE=1 SV=1 Transforming growth factor beta-1 proprotein OS=Homo 153 P01137 TGFB1 44.341 HUMAN 8.718 4 1.02 0.080 0.713427 0.929 0.093 0.149615 sapiens OX=9606 GN=TGFB1 PE=1 SV=2 Ryanodine receptor 2 OS=Homo sapiens OX=9606 154 Q92736 RYR2 564.563 HUMAN 0.262 4 1.13 0.301 0.610180 0.930 0.354 0.550912 GN=RYR2 PE=1 SV=3 Coagulation factor IX OS=Homo sapiens OX=9606 155 P00740 F9 51.778 HUMAN 4.338 5 0.95 0.033 0.019190 0.932 0.066 0.066817 GN=F9 PE=1 SV=2 Protein MENT OS=Homo sapiens OX=9606 GN=MENT 156 Q9BUN1 MENT 36.769 HUMAN 6.745 2 0.97 0.020 0.034109 0.933 0.021 0.001795 PE=2 SV=1 Neuropilin-1 OS=Homo sapiens OX=9606 GN=NRP1 157 O14786 NRP1 103.134 HUMAN 4.875 3 0.90 0.015 0.000108 0.936 0.018 0.001114 PE=1 SV=3 Fibrinogen gamma chain OS=Homo sapiens OX=9606 158 P02679 FGG 51.511 HUMAN 10.150 5 0.99 0.046 0.617911 0.936 0.028 0.006055 GN=FGG PE=1 SV=3 SERPINF Pigment epithelium-derived factor OS=Homo sapiens 159 P36955 46.312 HUMAN 40.910 22 1.15 0.096 0.033252 0.937 0.091 0.174676 1 OX=9606 GN=SERPINF1 PE=1 SV=4 Prolow-density lipoprotein receptor-related protein 1 160 Q07954 LRP1 504.602 HUMAN 1.563 6 1.12 0.079 0.038525 0.938 0.078 0.126044 OS=Homo sapiens OX=9606 GN=LRP1 PE=1 SV=2 Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 161 P35527 KRT9 62.064 HUMAN 21.990 12 0.90 0.158 0.233593 0.940 0.117 0.298712 GN=KRT9 PE=1 SV=3 Membrane primary amine oxidase OS=Homo sapiens 162 Q16853 AOC3 84.621 HUMAN 9.567 5 0.92 0.021 0.001123 0.941 0.032 0.013608 OX=9606 GN=AOC3 PE=1 SV=3 Osteopontin OS=Homo sapiens OX=9606 GN=SPP1 163 P10451 SPP1 35.422 HUMAN 5.414 1 0.93 0.117 0.273557 0.941 0.127 0.371072 PE=1 SV=1 Kelch-like protein 42 OS=Homo sapiens OX=9606 164 Q9P2K6 KLHL42 56.867 HUMAN 1.386 1 0.70 0.055 0.000956 0.942 0.027 0.020450 GN=KLHL42 PE=1 SV=2 Fetuin-B OS=Homo sapiens OX=9606 GN=FETUB PE=1 165 Q9UGM5 FETUB 42.055 HUMAN 21.200 10 0.69 0.117 0.001805 0.943 0.099 0.234496 SV=2 Delta-aminolevulinic acid dehydratase OS=Homo sapiens 166 P13716 ALAD 36.295 HUMAN 5.152 2 1.11 0.396 0.847616 0.943 0.381 0.535576 OX=9606 GN=ALAD PE=1 SV=1 Hypoxia up-regulated protein 1 OS=Homo sapiens 167 Q9Y4L1 HYOU1 111.335 HUMAN 4.705 3 0.89 0.102 0.062208 0.944 0.056 0.075021 OX=9606 GN=HYOU1 PE=1 SV=1 NIF3-like protein 1 OS=Homo sapiens OX=9606 168 Q9GZT8 NIF3L1 41.968 HUMAN 2.918 1 1.07 0.051 0.041652 0.946 0.066 0.124734 GN=NIF3L1 PE=1 SV=2 A0A0A0M Immunoglobulin kappa joining 1 OS=Homo sapiens 169 IGKJ1 1.394 HUMAN 66.670 2 0.82 0.032 0.001208 0.947 0.034 0.046205 T89 OX=9606 GN=IGKJ1 PE=4 SV=2 Muellerian-inhibiting factor OS=Homo sapiens OX=9606 170 P03971 AMH 59.194 HUMAN 7.679 5 0.92 0.078 0.074656 0.947 0.057 0.098164 GN=AMH PE=1 SV=3 Roundabout homolog 4 OS=Homo sapiens OX=9606 171 Q8WZ75 ROBO4 107.456 HUMAN 3.277 3 0.94 0.077 0.140493 0.947 0.031 0.015537 GN=ROBO4 PE=1 SV=1 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 172 Q10588 BST1 35.724 HUMAN 11.950 4 0.84 0.081 0.007038 0.948 0.093 0.248803 OS=Homo sapiens OX=9606 GN=BST1 PE=1 SV=2 Adhesion G protein-coupled receptor F5 OS=Homo 173 Q8IZF2 ADGRF5 149.456 HUMAN 2.080 2 0.93 0.034 0.007200 0.950 0.018 0.003019 sapiens OX=9606 GN=ADGRF5 PE=1 SV=3 Alpha-mannosidase 2 OS=Homo sapiens OX=9606 174 Q16706 MAN2A1 131.140 HUMAN 3.147 4 0.97 0.128 0.607951 0.950 0.298 0.591218 GN=MAN2A1 PE=1 SV=2 Complement C1q subcomponent subunit B OS=Homo 175 P02746 C1QB 26.722 HUMAN 33.990 20 1.18 0.048 0.001549 0.950 0.079 0.211539 sapiens OX=9606 GN=C1QB PE=1 SV=3 Interleukin-1 receptor accessory protein OS=Homo 176 Q9NPH3 IL1RAP 65.418 HUMAN 5.789 3 0.91 0.046 0.011608 0.951 0.047 0.071077 sapiens OX=9606 GN=IL1RAP PE=1 SV=2 Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA 177 P33908 MAN1A1 72.968 HUMAN 9.954 5 0.68 0.344 0.048035 0.952 0.078 0.221225 OS=Homo sapiens OX=9606 GN=MAN1A1 PE=1 SV=3 A0A087W IGKV3D- Immunoglobulin kappa variable 3D-15 OS=Homo sapiens 178 12.534 HUMAN 46.960 23 0.80 0.048 0.002636 0.956 0.044 0.126515 SY6 15 OX=9606 GN=IGKV3D-15 PE=3 SV=6 Desmoglein-2 OS=Homo sapiens OX=9606 GN=DSG2 179 Q14126 DSG2 122.293 HUMAN 4.741 5 0.92 0.031 0.003613 0.956 0.053 0.121392 PE=1 SV=2 CD44 antigen OS=Homo sapiens OX=9606 GN=CD44 180 P16070 CD44 81.537 HUMAN 4.313 3 0.98 0.033 0.321861 0.957 0.015 0.002838 PE=1 SV=3 Receptor-type tyrosine-protein phosphatase gamma 181 P23470 PTPRG 162.002 HUMAN 1.592 2 0.92 0.062 0.062018 0.958 0.030 0.063775 OS=Homo sapiens OX=9606 GN=PTPRG PE=1 SV=4 Serum albumin OS=Homo sapiens OX=9606 GN=ALB 182 P02768 ALB 69.366 HUMAN 89.660 436 1.03 0.023 0.032679 0.960 0.008 0.000388 PE=1 SV=2 SERPIN Heparin cofactor 2 OS=Homo sapiens OX=9606 183 P05546 57.070 HUMAN 63.530 67 0.45 0.485 0.014014 0.961 0.249 0.598262 D1 GN=SERPIND1 PE=1 SV=3 9 Prostaglandin-H2 D-isomerase OS=Homo sapiens 184 P41222 PTGDS 21.029 HUMAN 17.370 2 0.97 0.092 0.478562 0.961 0.047 0.124807 OX=9606 GN=PTGDS PE=1 SV=1 HSP90B Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 185 P14625 92.468 HUMAN 5.479 4 0.96 0.040 0.060088 0.963 0.058 0.200867 1 PE=1 SV=1 Vascular cell adhesion protein 1 OS=Homo sapiens 186 P19320 VCAM1 81.275 HUMAN 19.620 13 0.96 0.021 0.014631 0.964 0.035 0.078611 OX=9606 GN=VCAM1 PE=1 SV=1 Calumenin OS=Homo sapiens OX=9606 GN=CALU 187 O43852 CALU 37.107 HUMAN 8.889 3 0.90 0.021 0.000354 0.965 0.052 0.197156 PE=1 SV=2 Alpha-2-macroglobulin OS=Homo sapiens OX=9606 188 P01023 A2M 163.290 HUMAN 88.470 1126 0.96 0.015 0.004181 0.966 0.018 0.011534 GN=A2M PE=1 SV=3 Pyruvate kinase PKM OS=Homo sapiens OX=9606 189 P14618 PKM 57.936 HUMAN 13.560 6 1.00 0.031 0.803326 0.966 0.032 0.067910 GN=PKM PE=1 SV=4 Inhibin beta C chain OS=Homo sapiens OX=9606 190 P55103 INHBC 38.238 HUMAN 2.273 1 1.05 0.012 0.004819 0.968 0.012 0.012308 GN=INHBC PE=2 SV=1 A0A075B6I Immunoglobulin lambda variable 8-61 OS=Homo sapiens 191 IGLV8-61 12.814 HUMAN 20.490 4 0.98 0.036 0.189229 0.970 0.057 0.289293 0 OX=9606 GN=IGLV8-61 PE=3 SV=7 Complement factor D OS=Homo sapiens OX=9606 192 P00746 CFD 27.033 HUMAN 8.300 2 1.00 0.091 0.999999 0.970 0.079 0.400333 GN=CFD PE=1 SV=5 Peptidase inhibitor 16 OS=Homo sapiens OX=9606 193 Q6UXB8 PI16 49.471 HUMAN 16.410 10 1.26 0.216 0.085611 0.972 0.262 0.662589 GN=PI16 PE=1 SV=1 CD99 antigen OS=Homo sapiens OX=9606 GN=CD99 194 P14209 CD99 18.848 HUMAN 7.568 1 0.88 0.139 0.090684 0.973 0.154 0.630874 PE=1 SV=1 A0A0C4D IGKV2- Immunoglobulin kappa variable 2-24 OS=Homo sapiens 195 13.079 HUMAN 62.500 7 0.90 0.019 0.001588 0.973 0.040 0.265724 H68 24 OX=9606 GN=IGKV2-24 PE=3 SV=1 Out at first protein homolog OS=Homo sapiens OX=9606 196 Q86UD1 OAF 30.688 HUMAN 10.260 2 1.00 0.184 0.927252 0.974 0.046 0.313559 GN=OAF PE=2 SV=1 A0A0B4J1 IGHV3- Immunoglobulin heavy variable 3-73 OS=Homo sapiens 197 12.858 HUMAN 67.230 11 1.22 0.162 0.049834 0.977 0.169 0.654924 V6 73 OX=9606 GN=IGHV3-73 PE=3 SV=1 Fibrinogen beta chain OS=Homo sapiens OX=9606 198 P02675 FGB 55.928 HUMAN 18.530 7 1.08 0.132 0.273213 0.978 0.072 0.505446 GN=FGB PE=1 SV=2 Alpha-1,6-mannosylglycoprotein 6-beta-N- 199 Q09328 MGAT5 84.542 HUMAN acetylglucosaminyltransferase A OS=Homo sapiens 2.429 2 1.04 0.136 0.645592 0.980 0.111 0.639040 OX=9606 GN=MGAT5 PE=1 SV=1 Nidogen-2 OS=Homo sapiens OX=9606 GN=NID2 PE=1 200 Q14112 NID2 151.253 HUMAN 2.400 3 0.94 0.053 0.049369 0.981 0.039 0.301204 SV=3 L-selectin OS=Homo sapiens OX=9606 GN=SELL PE=1 201 P14151 SELL 42.187 HUMAN 9.946 9 0.90 0.062 0.013429 0.982 0.020 0.102701 SV=2 A0A0A0M IGHV3- Immunoglobulin heavy variable 3-49 OS=Homo sapiens 202 13.056 HUMAN 62.180 17 0.77 0.122 0.005972 0.983 0.089 0.636303 S15 49 OX=9606 GN=IGHV3-49 PE=3 SV=1 Intercellular adhesion molecule 3 OS=Homo sapiens 203 P32942 ICAM3 59.540 HUMAN 6.764 3 0.94 0.023 0.004181 0.983 0.048 0.445612 OX=9606 GN=ICAM3 PE=1 SV=2 GDH/6PGL endoplasmic bifunctional protein OS=Homo 204 O95479 H6PD 88.892 HUMAN 1.011 1 0.92 0.091 0.142890 0.987 0.027 0.375092 sapiens OX=9606 GN=H6PD PE=1 SV=2 Fructose-bisphosphate aldolase A OS=Homo sapiens 205 P04075 ALDOA 39.420 HUMAN 24.450 9 1.12 0.046 0.006031 0.987 0.060 0.611530 OX=9606 GN=ALDOA PE=1 SV=2 Coagulation factor X OS=Homo sapiens OX=9606 206 P00742 F10 54.731 HUMAN 21.720 11 0.89 0.256 0.287129 0.989 0.188 0.780006 GN=F10 PE=1 SV=2 A0A0C4D IGHV4- Immunoglobulin heavy variable 4-61 OS=Homo sapiens 207 13.066 HUMAN 44.070 11 1.06 0.030 0.040039 0.991 0.015 0.308072 H41 61 OX=9606 GN=IGHV4-61 PE=3 SV=1 Carboxypeptidase Q OS=Homo sapiens OX=9606 208 Q9Y646 CPQ 51.887 HUMAN 4.237 2 0.89 0.024 0.000458 0.992 0.053 0.722781 GN=CPQ PE=1 SV=1 Intercellular adhesion molecule 1 OS=Homo sapiens 209 P05362 ICAM1 57.825 HUMAN 16.350 6 0.89 0.025 0.000446 0.993 0.022 0.495351 OX=9606 GN=ICAM1 PE=1 SV=2 Complement C3 OS=Homo sapiens OX=9606 GN=C3 210 P01024 C3 187.147 HUMAN 83.580 565 0.99 0.009 0.089010 0.993 0.018 0.405017 PE=1 SV=2 Adipocyte plasma membrane-associated protein 211 Q9HDC9 APMAP 46.480 HUMAN 18.510 7 1.46 0.085 0.000619 0.993 0.161 0.825831 OS=Homo sapiens OX=9606 GN=APMAP PE=1 SV=2 Vitamin K-dependent protein S OS=Homo sapiens 212 P07225 PROS1 75.122 HUMAN 33.730 35 0.94 0.180 0.379645 0.994 0.155 0.833635 OX=9606 GN=PROS1 PE=1 SV=1 Proprotein convertase subtilisin/kexin type 9 OS=Homo 213 Q8NBP7 PCSK9 74.286 HUMAN 9.393 5 1.00 0.039 0.840259 0.994 0.088 0.832368 sapiens OX=9606 GN=PCSK9 PE=1 SV=3 L-lactate dehydrogenase B chain OS=Homo sapiens 214 P07195 LDHB 36.638 HUMAN 20.660 6 1.02 0.027 0.199831 0.995 0.049 0.813317 OX=9606 GN=LDHB PE=1 SV=2 10 IGHV3- Immunoglobulin heavy variable 3-48 OS=Homo sapiens 215 P01763 12.812 HUMAN 76.070 74 0.64 0.342 0.029942 0.996 0.117 0.871221 48 OX=9606 GN=IGHV3-48 PE=1 SV=2 Dipeptidase 2 OS=Homo sapiens OX=9606 GN=DPEP2 216 Q9H4A9 DPEP2 53.365 HUMAN 8.436 4 0.94 0.017 0.004607 0.998 0.035 0.903003 PE=1 SV=3 Multimerin-1 OS=Homo sapiens OX=9606 GN=MMRN1 217 Q13201 MMRN1 138.109 HUMAN 15.640 19 1.02 0.024 0.241981 0.998 0.024 0.871216 PE=1 SV=3 Uromodulin OS=Homo sapiens OX=9606 GN=UMOD 218 P07911 UMOD 69.760 HUMAN 4.688 3 0.88 0.017 0.000075 1.002 0.037 0.915574 PE=1 SV=1 SERPIN Serpin A11 OS=Homo sapiens OX=9606 219 Q86U17 46.989 HUMAN 18.720 9 1.01 0.063 0.901238 1.002 0.075 0.999996 A11 GN=SERPINA11 PE=2 SV=2 Nidogen-1 OS=Homo sapiens OX=9606 GN=NID1 PE=1 220 P14543 NID1 136.376 HUMAN 10.830 12 1.02 0.034 0.337991 1.002 0.034 0.909661 SV=3 Collagen alpha-2(I) chain OS=Homo sapiens OX=9606 221 P08123 COL1A2 129.314 HUMAN 4.319 4 1.19 0.178 0.117519 1.002 0.273 0.820137 GN=COL1A2 PE=1 SV=7 IGHV1- Immunoglobulin heavy variable 1-46 OS=Homo sapiens 222 P01743 12.933 HUMAN 66.670 15 1.02 0.031 0.257685 1.003 0.060 0.947478 46 OX=9606 GN=IGHV1-46 PE=1 SV=2 Alpha-synuclein OS=Homo sapiens OX=9606 GN=SNCA 223 P37840 SNCA 14.460 HUMAN 11.430 1 1.09 0.046 0.016687 1.003 0.046 0.932629 PE=1 SV=1 SERPIN Thyroxine-binding globulin OS=Homo sapiens OX=9606 224 P05543 46.324 HUMAN 49.400 42 0.64 0.181 0.004550 1.004 0.123 0.975458 A7 GN=SERPINA7 PE=1 SV=2 Complement component C6 OS=Homo sapiens OX=9606 225 P13671 C6 104.785 HUMAN 27.620 35 0.99 0.019 0.432004 1.004 0.017 0.648263 GN=C6 PE=1 SV=3 Plastin-2 OS=Homo sapiens OX=9606 GN=LCP1 PE=1 226 P13796 LCP1 70.288 HUMAN 33.650 18 0.77 0.038 0.000100 1.005 0.090 0.964602 SV=6 Platelet glycoprotein V OS=Homo sapiens OX=9606 227 P40197 GP5 60.959 HUMAN 18.750 9 0.98 0.033 0.282629 1.010 0.036 0.594642 GN=GP5 PE=1 SV=1 Carboxypeptidase N catalytic chain OS=Homo sapiens 228 P15169 CPN1 52.286 HUMAN 46.720 20 1.09 0.073 0.058208 1.014 0.038 0.493532 OX=9606 GN=CPN1 PE=1 SV=1 Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 229 P06733 ENO1 47.169 HUMAN 8.525 3 1.09 0.082 0.124200 1.014 0.022 0.296690 PE=1 SV=2 Lysosome-associated membrane glycoprotein 2 230 P13473 LAMP2 44.960 HUMAN 5.122 2 0.94 0.089 0.188471 1.015 0.070 0.701620 OS=Homo sapiens OX=9606 GN=LAMP2 PE=1 SV=2 Coagulation factor XII OS=Homo sapiens OX=9606 231 P00748 F12 67.792 HUMAN 23.410 19 0.74 0.245 0.044912 1.018 0.179 0.947833 GN=F12 PE=1 SV=3 Gamma-glutamyl hydrolase OS=Homo sapiens OX=9606 232 Q92820 GGH 35.964 HUMAN 18.870 6 1.00 0.018 0.999987 1.021 0.015 0.040186 GN=GGH PE=1 SV=2 Apolipoprotein C-IV OS=Homo sapiens OX=9606 233 P55056 APOC4 14.553 HUMAN 33.860 4 1.12 0.176 0.215252 1.023 0.081 0.597304 GN=APOC4 PE=1 SV=1 Hyaluronan-binding protein 2 OS=Homo sapiens 234 Q14520 HABP2 62.671 HUMAN 21.070 13 0.94 0.047 0.035673 1.024 0.055 0.417469 OX=9606 GN=HABP2 PE=1 SV=1 A0A0A0M IGKV3D- Immunoglobulin kappa variable 3D-11 OS=Homo sapiens 235 12.625 HUMAN 53.040 40 0.98 0.123 0.691159 1.024 0.012 0.012317 RZ8 11 OX=9606 GN=IGKV3D-11 PE=3 SV=6 Tubulin beta-4A chain OS=Homo sapiens OX=9606 236 P04350 TUBB4A 49.586 HUMAN 2.252 1 1.14 0.071 0.035866 1.025 0.069 0.552948 GN=TUBB4A PE=1 SV=2 IGKV1D- Immunoglobulin kappa variable 1D-33 OS=Homo sapiens 237 P01593 12.848 HUMAN 52.140 28 1.07 0.113 0.302947 1.028 0.095 0.606192 33 OX=9606 GN=IGKV1D-33 PE=1 SV=2 Immunoglobulin lambda variable 1-51 OS=Homo sapiens 238 P01701 IGLV1-51 12.249 HUMAN 41.030 16 0.92 0.111 0.131328 1.032 0.096 0.557224 OX=9606 GN=IGLV1-51 PE=1 SV=2 Trem-like transcript 1 protein OS=Homo sapiens 239 Q86YW5 TREML1 32.678 HUMAN 5.145 1 1.01 0.093 0.934421 1.035 0.107 0.578235 OX=9606 GN=TREML1 PE=1 SV=2 Immunoglobulin heavy constant delta OS=Homo sapiens 240 P01880 IGHD 42.353 HUMAN 30.990 16 0.38 0.220 0.000462 1.037 0.131 0.638022 OX=9606 GN=IGHD PE=1 SV=3 Glutathione reductase, mitochondrial OS=Homo sapiens 241 P00390 GSR 56.257 HUMAN 2.299 1 1.05 0.055 0.162970 1.038 0.097 0.496882 OX=9606 GN=GSR PE=1 SV=2 Macrophage mannose receptor 1 OS=Homo sapiens 242 P22897 MRC1 166.010 HUMAN 0.893 1 0.86 0.185 0.180650 1.039 0.166 0.762445 OX=9606 GN=MRC1 PE=1 SV=1 Beta-2-microglobulin OS=Homo sapiens OX=9606 243 P61769 B2M 13.714 HUMAN 19.330 3 0.92 0.142 0.241222 1.039 0.197 0.819336 GN=B2M PE=1 SV=1 Endoplasmic reticulum aminopeptidase 1 OS=Homo 244 Q9NZ08 ERAP1 107.234 HUMAN 2.444 2 1.03 0.053 0.314115 1.043 0.029 0.062772 sapiens OX=9606 GN=ERAP1 PE=1 SV=3 Secreted phosphoprotein 24 OS=Homo sapiens 245 Q13103 SPP2 24.337 HUMAN 21.330 6 1.09 0.353 0.765106 1.044 0.100 0.430046 OX=9606 GN=SPP2 PE=1 SV=1 Oncoprotein-induced transcript 3 protein OS=Homo 246 Q8WWZ8 OIT3 60.021 HUMAN 3.119 2 1.14 0.068 0.030539 1.045 0.035 0.086434 sapiens OX=9606 GN=OIT3 PE=1 SV=2 11 Complement C5 OS=Homo sapiens OX=9606 GN=C5 247 P01031 C5 188.304 HUMAN 32.280 58 2.14 0.070 0.000017 1.046 0.141 0.600069 PE=1 SV=4 Leukotriene A-4 hydrolase OS=Homo sapiens OX=9606 248 P09960 LTA4H 69.285 HUMAN 3.601 2 0.94 0.061 0.100631 1.047 0.061 0.179778 GN=LTA4H PE=1 SV=2 Multiple inositol polyphosphate phosphatase 1 OS=Homo 249 Q9UNW1 MINPP1 55.051 HUMAN 6.160 3 1.12 0.177 0.286921 1.047 0.167 0.668289 sapiens OX=9606 GN=MINPP1 PE=1 SV=1 PGLYRP N-acetylmuramoyl-L-alanine amidase OS=Homo sapiens 250 Q96PD5 62.216 HUMAN 57.120 48 0.74 0.114 0.003965 1.048 0.167 0.674189 2 OX=9606 GN=PGLYRP2 PE=1 SV=1 Apolipoprotein A-II OS=Homo sapiens OX=9606 251 P02652 APOA2 11.175 HUMAN 77.000 85 0.76 0.802 0.248517 1.052 0.304 0.992186 GN=APOA2 PE=1 SV=1 A0A0G2J IGHV1- Immunoglobulin heavy variable 1-69-2 OS=Homo sapiens 252 12.871 HUMAN 61.540 18 0.89 0.441 0.454098 1.052 0.280 0.893490 MI3 69-2 OX=9606 GN=IGHV1-69-2 PE=3 SV=2 Trypsin-1 OS=Homo sapiens OX=9606 GN=PRSS1 253 P07477 PRSS1 26.558 HUMAN 14.170 4 0.94 0.083 0.167816 1.052 0.111 0.416476 PE=1 SV=1 Complement C4-B OS=Homo sapiens OX=9606 GN=C4B 254 P0C0L5 C4B 192.750 HUMAN 70.930 327 1.94 0.351 0.022316 1.052 0.177 0.645099 PE=1 SV=2 IGHV3- Immunoglobulin heavy variable 3-30-3 OS=Homo sapiens 255 P0DP02 12.989 HUMAN 61.540 52 1.10 0.060 0.024142 1.053 0.097 0.333967 30-3 OX=9606 GN=IGHV3-30-3 PE=3 SV=1 A0A075B6 IGKV2D- Immunoglobulin kappa variable 2D-30 OS=Homo sapiens 256 13.215 HUMAN 62.500 14 0.91 0.038 0.004332 1.060 0.042 0.039512 S6 30 OX=9606 GN=IGKV2D-30 PE=3 SV=1 Cation-independent mannose-6-phosphate receptor 257 P11717 IGF2R 274.372 HUMAN 1.124 5 0.94 0.009 0.000625 1.062 0.022 0.012066 OS=Homo sapiens OX=9606 GN=IGF2R PE=1 SV=3 Serglycin OS=Homo sapiens OX=9606 GN=SRGN PE=1 258 P10124 SRGN 17.652 HUMAN 8.228 1 1.08 0.024 0.008466 1.062 0.012 0.002085 SV=3 Scavenger receptor cysteine-rich type 1 protein M130 259 Q86VB7 CD163 125.450 HUMAN 5.190 5 0.75 0.171 0.013097 1.063 0.066 0.117668 OS=Homo sapiens OX=9606 GN=CD163 PE=1 SV=2 IGKV3- Immunoglobulin kappa variable 3-20 OS=Homo sapiens 260 P01619 12.557 HUMAN 84.480 59 1.07 0.070 0.118177 1.064 0.223 0.650423 20 OX=9606 GN=IGKV3-20 PE=1 SV=2 Alpha-1B-glycoprotein OS=Homo sapiens OX=9606 261 P04217 A1BG 54.253 HUMAN 61.820 80 0.62 0.202 0.006043 1.065 0.235 0.695598 GN=A1BG PE=1 SV=4 Proteoglycan 4 OS=Homo sapiens OX=9606 GN=PRG4 262 Q92954 PRG4 151.060 HUMAN 12.540 16 1.09 0.162 0.306201 1.065 0.044 0.032062 PE=1 SV=3 Apolipoprotein E OS=Homo sapiens OX=9606 GN=APOE 263 P02649 APOE 36.154 HUMAN 83.280 63 1.48 0.095 0.000758 1.065 0.101 0.255185 PE=1 SV=1 Multiple epidermal growth factor-like domains protein 8 264 Q7Z7M0 MEGF8 303.098 HUMAN 2.320 5 0.95 0.042 0.047987 1.066 0.188 0.536209 OS=Homo sapiens OX=9606 GN=MEGF8 PE=1 SV=2 Apolipoprotein M OS=Homo sapiens OX=9606 265 O95445 APOM 21.253 HUMAN 53.720 17 2.01 0.338 0.023471 1.067 0.187 0.598399 GN=APOM PE=1 SV=2 Myeloperoxidase OS=Homo sapiens OX=9606 GN=MPO 266 P05164 MPO 83.868 HUMAN 2.953 2 1.46 0.048 0.000563 1.069 0.030 0.021915 PE=1 SV=1 Immunoglobulin lambda variable 1-47 OS=Homo sapiens 267 P01700 IGLV1-47 12.283 HUMAN 52.990 16 1.07 0.025 0.004636 1.071 0.021 0.001985 OX=9606 GN=IGLV1-47 PE=1 SV=2 SERPIN Plasma serine protease inhibitor OS=Homo sapiens 268 P05154 45.674 HUMAN 39.160 14 1.36 0.168 0.012714 1.071 0.106 0.244747 A5 OX=9606 GN=SERPINA5 PE=1 SV=3 A0A0J9YX IGHV3- Immunoglobulin heavy variable 3-64D OS=Homo sapiens 269 12.823 HUMAN 71.790 19 1.05 0.082 0.296872 1.072 0.090 0.178685 35 64D OX=9606 GN=IGHV3-64D PE=3 SV=1 Complement component C8 alpha chain OS=Homo 270 P07357 C8A 65.163 HUMAN 31.850 24 1.04 0.103 0.461777 1.080 0.088 0.130009 sapiens OX=9606 GN=C8A PE=1 SV=2 Dystroglycan OS=Homo sapiens OX=9606 GN=DAG1 271 Q14118 DAG1 97.441 HUMAN 1.788 1 1.12 0.204 0.404167 1.083 0.158 0.373529 PE=1 SV=2 Immunoglobulin heavy constant alpha 1 OS=Homo 272 P01876 IGHA1 37.654 HUMAN 81.300 109 0.41 0.272 0.003751 1.086 0.260 0.768089 sapiens OX=9606 GN=IGHA1 PE=1 SV=2 Matrix metalloproteinase-9 OS=Homo sapiens OX=9606 273 P14780 MMP9 78.458 HUMAN 9.335 5 1.06 0.099 0.305805 1.086 0.090 0.128651 GN=MMP9 PE=1 SV=3 Nucleobindin-1 OS=Homo sapiens OX=9606 GN=NUCB1 274 Q02818 NUCB1 53.879 HUMAN 5.206 2 0.99 0.101 0.739905 1.091 0.108 0.223836 PE=1 SV=4 Trans-Golgi network integral membrane protein 2 275 O43493 TGOLN2 51.018 HUMAN 3.758 2 1.05 0.070 0.194928 1.093 0.069 0.050605 OS=Homo sapiens OX=9606 GN=TGOLN2 PE=1 SV=3 Complement C1r subcomponent-like protein OS=Homo 276 Q9NZP8 C1RL 53.498 HUMAN 33.880 17 0.84 0.047 0.001176 1.100 0.063 0.027943 sapiens OX=9606 GN=C1RL PE=1 SV=2 Mannan-binding lectin serine protease 1 OS=Homo 277 P48740 MASP1 79.246 HUMAN 15.310 13 1.48 0.221 0.024892 1.103 0.285 0.646414 sapiens OX=9606 GN=MASP1 PE=1 SV=3 Vinculin OS=Homo sapiens OX=9606 GN=VCL PE=1 278 P18206 VCL 123.798 HUMAN 7.407 7 1.11 0.261 0.459364 1.104 0.229 0.419972 SV=4 12 Mannan-binding lectin serine protease 2 OS=Homo 279 O00187 MASP2 75.702 HUMAN 13.270 10 1.09 0.281 0.637365 1.108 0.318 0.593595 sapiens OX=9606 GN=MASP2 PE=1 SV=4 A0A075B6I Immunoglobulin lambda variable 7-46 OS=Homo sapiens 280 IGLV7-46 12.468 HUMAN 15.380 2 1.01 0.120 0.999999 1.110 0.084 0.095018 9 OX=9606 GN=IGLV7-46 PE=3 SV=4 Coronin-1A OS=Homo sapiens OX=9606 GN=CORO1A 281 P31146 CORO1A 51.026 HUMAN 3.471 1 1.01 0.076 0.911363 1.111 0.068 0.055219 PE=1 SV=4 Glutathione peroxidase 3 OS=Homo sapiens OX=9606 282 P22352 GPX3 25.552 HUMAN 32.300 11 1.01 0.094 0.796410 1.114 0.135 0.146052 GN=GPX3 PE=1 SV=2 Immunoglobulin lambda-like polypeptide 5 OS=Homo 283 B9A064 IGLL5 23.063 HUMAN 45.790 50 1.14 0.206 0.357742 1.114 0.151 0.282600 sapiens OX=9606 GN=IGLL5 PE=2 SV=2 Complement component C8 beta chain OS=Homo 284 P07358 C8B 67.046 HUMAN 36.040 21 1.25 0.066 0.001745 1.117 0.072 0.029406 sapiens OX=9606 GN=C8B PE=1 SV=3 Golgi membrane protein 1 OS=Homo sapiens OX=9606 285 Q8NBJ4 GOLM1 45.333 HUMAN 8.229 3 1.18 0.059 0.003198 1.118 0.053 0.009763 GN=GOLM1 PE=1 SV=1 A0A0B4J1 IGHV3- Immunoglobulin heavy variable 3-72 OS=Homo sapiens 286 13.203 HUMAN 81.510 37 1.20 0.304 0.257501 1.119 0.010 0.000015 Y9 72 OX=9606 GN=IGHV3-72 PE=3 SV=1 Immunoglobulin lambda variable 7-43 OS=Homo sapiens 287 P04211 IGLV7-43 12.451 HUMAN 23.080 4 1.06 0.031 0.014347 1.120 0.132 0.123239 OX=9606 GN=IGLV7-43 PE=3 SV=2 Catalase OS=Homo sapiens OX=9606 GN=CAT PE=1 288 P04040 CAT 59.756 HUMAN 7.021 3 1.43 0.211 0.015972 1.120 0.040 0.003228 SV=3 A0A0B4J1 IGHV2- Immunoglobulin heavy variable 2-26 OS=Homo sapiens 289 13.182 HUMAN 43.700 6 1.12 0.028 0.000811 1.121 0.017 0.000107 V2 26 OX=9606 GN=IGHV2-26 PE=3 SV=1 IGHV3- Immunoglobulin heavy variable 3-33 OS=Homo sapiens 290 P01772 13.074 HUMAN 61.540 49 1.24 0.046 0.000504 1.123 0.142 0.137468 33 OX=9606 GN=IGHV3-33 PE=1 SV=2 Low affinity immunoglobulin gamma Fc region receptor III- 291 P08637 FCGR3A 29.089 HUMAN A OS=Homo sapiens OX=9606 GN=FCGR3A PE=1 12.990 3 0.86 0.037 0.000721 1.131 0.067 0.017755 SV=2 Immunoglobulin lambda-like polypeptide 1 OS=Homo 292 P15814 IGLL1 22.963 HUMAN 19.250 7 1.05 0.027 0.031777 1.135 0.014 0.000354 sapiens OX=9606 GN=IGLL1 PE=1 SV=1 Immunoglobulin heavy variable 1-2 OS=Homo sapiens 293 P23083 IGHV1-2 13.085 HUMAN 73.500 20 1.31 0.477 0.313127 1.146 0.204 0.214360 OX=9606 GN=IGHV1-2 PE=1 SV=2 A0A075B6 IGKV1- Immunoglobulin kappa variable 1-27 OS=Homo sapiens 294 12.711 HUMAN 54.700 36 1.05 0.131 0.545528 1.148 0.150 0.136001 S5 27 OX=9606 GN=IGKV1-27 PE=3 SV=1 IGKV1- Immunoglobulin kappa variable 1-16 OS=Homo sapiens 295 P04430 12.618 HUMAN 54.700 28 1.12 0.046 0.004810 1.158 0.047 0.002148 16 OX=9606 GN=IGKV1-16 PE=1 SV=2 Apolipoprotein B-100 OS=Homo sapiens OX=9606 296 P04114 APOB 515.600 HUMAN 65.260 705 1.44 0.593 0.273788 1.167 0.346 0.422301 GN=APOB PE=1 SV=2 Hemopexin OS=Homo sapiens OX=9606 GN=HPX PE=1 297 P02790 HPX 51.676 HUMAN 81.820 136 0.62 0.261 0.013569 1.168 0.219 0.234421 SV=2 Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo 298 P62942 FKBP1A 11.951 HUMAN 28.700 3 1.25 0.059 0.000962 1.173 0.089 0.014288 sapiens OX=9606 GN=FKBP1A PE=1 SV=2 A0A0A0M IGHV1- Immunoglobulin heavy variable 1-45 OS=Homo sapiens 299 13.508 HUMAN 34.190 6 0.50 0.471 0.050311 1.178 0.499 0.836769 S14 45 OX=9606 GN=IGHV1-45 PE=3 SV=1 Integrin alpha-IIb OS=Homo sapiens OX=9606 300 P08514 ITGA2B 113.376 HUMAN 2.021 2 1.21 0.112 0.022700 1.178 0.094 0.023540 GN=ITGA2B PE=1 SV=3 SPARC OS=Homo sapiens OX=9606 GN=SPARC PE=1 301 P09486 SPARC 34.632 HUMAN 12.870 4 1.19 0.105 0.027704 1.181 0.082 0.012401 SV=1 A0A0C4D Immunoglobulin heavy variable 1-3 OS=Homo sapiens 302 IGHV1-3 13.008 HUMAN 63.250 26 1.31 0.110 0.007396 1.182 0.129 0.050696 H29 OX=9606 GN=IGHV1-3 PE=3 SV=1 Superoxide dismutase [Cu-Zn] OS=Homo sapiens 303 P00441 SOD1 15.936 HUMAN 15.580 2 1.21 0.162 0.066703 1.183 0.104 0.025932 OX=9606 GN=SOD1 PE=1 SV=2 SERPIN Plasma protease C1 inhibitor OS=Homo sapiens 304 P05155 55.154 HUMAN 55.400 88 0.91 0.338 0.420288 1.185 0.376 0.528565 G1 OX=9606 GN=SERPING1 PE=1 SV=2 Tubulin alpha-1B chain OS=Homo sapiens OX=9606 305 P68363 TUBA1B 50.151 HUMAN 5.322 2 1.10 0.084 0.116157 1.189 0.082 0.025781 GN=TUBA1B PE=1 SV=1 SERPIN Protein Z-dependent protease inhibitor OS=Homo sapiens 306 Q9UK55 50.707 HUMAN 28.380 13 1.30 0.092 0.003143 1.197 0.056 0.002075 A10 OX=9606 GN=SERPINA10 PE=1 SV=1 A0A0B4J1 Immunoglobulin lambda variable 1-36 OS=Homo sapiens 307 IGLV1-36 12.478 HUMAN 29.060 3 1.01 0.109 0.999998 1.199 0.195 0.109723 U3 OX=9606 GN=IGLV1-36 PE=3 SV=5 LGALS3 Galectin-3-binding protein OS=Homo sapiens OX=9606 308 Q08380 65.330 HUMAN 27.860 28 1.55 0.174 0.004042 1.202 0.240 0.163617 BP GN=LGALS3BP PE=1 SV=1 Actin-related protein 3 OS=Homo sapiens OX=9606 309 P61158 ACTR3 47.371 HUMAN 2.871 1 1.11 0.216 0.480874 1.207 0.243 0.268817 GN=ACTR3 PE=1 SV=3 13 Extracellular superoxide dismutase [Cu-Zn] OS=Homo 310 P08294 SOD3 25.851 HUMAN 20.000 4 1.03 0.044 0.197873 1.216 0.076 0.005276 sapiens OX=9606 GN=SOD3 PE=1 SV=2 Transferrin receptor protein 1 OS=Homo sapiens 311 P02786 TFRC 84.871 HUMAN 36.840 26 0.88 0.132 0.069263 1.217 0.048 0.000701 OX=9606 GN=TFRC PE=1 SV=2 Apolipoprotein(a) OS=Homo sapiens OX=9606 GN=LPA 312 P08519 LPA 501.316 HUMAN 28.630 30 0.95 0.106 0.289777 1.226 0.085 0.007442 PE=1 SV=1 IGKV1- Immunoglobulin kappa variable 1-39 OS=Homo sapiens 313 P01597 12.737 HUMAN 70.940 47 1.15 0.157 0.143205 1.227 0.139 0.034634 39 OX=9606 GN=IGKV1-39 PE=1 SV=2 Poliovirus receptor OS=Homo sapiens OX=9606 314 P15151 PVR 45.302 HUMAN 7.674 4 1.18 0.262 0.260498 1.228 0.322 0.242694 GN=PVR PE=1 SV=2 A0A075B6 IGHV3- Immunoglobulin heavy variable 3-64 OS=Homo sapiens 315 12.891 HUMAN 51.690 13 1.02 0.247 0.940317 1.233 0.264 0.192716 Q5 64 OX=9606 GN=IGHV3-64 PE=3 SV=1 Immunoglobulin epsilon heavy chain OS=Homo sapiens 316 P0DOX4 IGE 60.322 HUMAN 9.689 5 1.22 0.139 0.050097 1.246 0.181 0.068298 OX=9606 PE=1 SV=1 Complement component C8 gamma chain OS=Homo 317 P07360 C8G 22.277 HUMAN 54.460 12 1.80 0.333 0.026090 1.246 0.386 0.464392 sapiens OX=9606 GN=C8G PE=1 SV=3 Immunoglobulin lambda variable 1-40 OS=Homo sapiens 318 P01703 IGLV1-40 12.302 HUMAN 45.760 17 1.10 0.053 0.015735 1.248 0.118 0.018890 OX=9606 GN=IGLV1-40 PE=1 SV=2 Lipopolysaccharide-binding protein OS=Homo sapiens 319 P18428 LBP 53.383 HUMAN 14.760 6 2.14 0.307 0.010750 1.254 0.211 0.094515 OX=9606 GN=LBP PE=1 SV=3 Complement factor H-related protein 3 OS=Homo sapiens 320 Q02985 CFHR3 37.323 HUMAN 13.640 7 0.94 0.024 0.011750 1.257 0.034 0.000892 OX=9606 GN=CFHR3 PE=1 SV=2 Immunoglobulin heavy variable 3-7 OS=Homo sapiens 321 P01780 IGHV3-7 12.943 HUMAN 86.320 76 1.02 0.271 0.940895 1.258 0.261 0.171547 OX=9606 GN=IGHV3-7 PE=1 SV=2 Fermitin family homolog 3 OS=Homo sapiens OX=9606 322 Q86UX7 FERMT3 75.952 HUMAN 1.199 1 1.37 0.096 0.007601 1.262 0.081 0.010913 GN=FERMT3 PE=1 SV=1 IGHV3- Immunoglobulin heavy variable 3-23 OS=Homo sapiens 323 P01764 12.582 HUMAN 76.070 42 1.40 0.184 0.016790 1.262 0.156 0.030937 23 OX=9606 GN=IGHV3-23 PE=1 SV=2 Complement C1s subcomponent OS=Homo sapiens 324 P09871 C1S 76.684 HUMAN 47.670 42 1.12 0.173 0.276131 1.273 0.098 0.005564 OX=9606 GN=C1S PE=1 SV=1 Cathepsin G OS=Homo sapiens OX=9606 GN=CTSG 325 P08311 CTSG 28.837 HUMAN 5.098 1 1.27 0.034 0.000824 1.274 0.019 0.000133 PE=1 SV=2 Band 3 anion transport protein OS=Homo sapiens 326 P02730 SLC4A1 101.791 HUMAN 4.171 3 3.78 0.119 0.000022 1.277 0.060 0.000873 OX=9606 GN=SLC4A1 PE=1 SV=3 Oncostatin-M-specific receptor subunit beta OS=Homo 327 Q99650 OSMR 110.508 HUMAN 0.817 1 0.52 0.837 0.145686 1.281 0.184 0.084332 sapiens OX=9606 GN=OSMR PE=1 SV=1 Transforming growth factor-beta-induced protein ig-h3 328 Q15582 TGFBI 74.680 HUMAN 27.380 15 0.66 0.309 0.028489 1.289 0.283 0.144018 OS=Homo sapiens OX=9606 GN=TGFBI PE=1 SV=1 A0A0B4J1 Immunoglobulin lambda variable 9-49 OS=Homo sapiens 329 IGLV9-49 13.024 HUMAN 16.260 4 1.07 0.136 0.358143 1.291 0.406 0.243043 Y8 OX=9606 GN=IGLV9-49 PE=1 SV=1 Immunoglobulin lambda variable 6-57 OS=Homo sapiens 330 P01721 IGLV6-57 12.566 HUMAN 63.250 14 1.08 0.049 0.031208 1.297 0.212 0.044062 OX=9606 GN=IGLV6-57 PE=1 SV=2 Glucosidase 2 subunit beta OS=Homo sapiens OX=9606 331 P14314 PRKCSH 59.425 HUMAN 2.083 1 0.95 0.044 0.073234 1.300 0.363 0.248651 GN=PRKCSH PE=1 SV=2 Carbonic anhydrase 1 OS=Homo sapiens OX=9606 332 P00915 CA1 28.870 HUMAN 39.850 14 1.73 0.188 0.005450 1.302 0.151 0.022252 GN=CA1 PE=1 SV=2 SERPINF Alpha-2-antiplasmin OS=Homo sapiens OX=9606 333 P08697 54.565 HUMAN 49.690 50 1.22 0.377 0.432830 1.303 0.417 0.315564 2 GN=SERPINF2 PE=1 SV=3 SELENB Methanethiol oxidase OS=Homo sapiens OX=9606 334 Q13228 52.391 HUMAN 11.440 4 1.72 0.210 0.005857 1.319 0.216 0.057306 P1 GN=SELENBP1 PE=1 SV=2 Immunoglobulin kappa variable 1-5 OS=Homo sapiens 335 P01602 IGKV1-5 12.781 HUMAN 44.440 37 1.28 0.147 0.045842 1.326 0.129 0.023240 OX=9606 GN=IGKV1-5 PE=1 SV=2 Coagulation factor V OS=Homo sapiens OX=9606 336 P12259 F5 251.701 HUMAN 16.640 37 1.21 0.135 0.040682 1.330 0.208 0.040568 GN=F5 PE=1 SV=4 Tubulin polyglutamylase TTLL7 OS=Homo sapiens 337 Q6ZT98 TTLL7 102.998 HUMAN 0.676 2 1.08 0.293 0.778550 1.340 0.299 0.188915 OX=9606 GN=TTLL7 PE=1 SV=2 Adenylyl cyclase-associated protein 1 OS=Homo sapiens 338 Q01518 CAP1 51.901 HUMAN 5.263 2 1.48 0.090 0.000543 1.348 0.067 0.000613 OX=9606 GN=CAP1 PE=1 SV=5 A0A0B4J1 IGHV3- Immunoglobulin heavy variable 3-21 OS=Homo sapiens 339 12.840 HUMAN 67.520 62 1.40 0.164 0.013829 1.354 0.143 0.010504 V1 21 OX=9606 GN=IGHV3-21 PE=1 SV=1 A0A0B4J2 IGKV1D- Immunoglobulin kappa variable 1D-13 OS=Homo sapiens 340 12.569 HUMAN 54.700 14 1.19 0.029 0.001276 1.356 0.034 0.000369 D9 13 OX=9606 GN=IGKV1D-13 PE=3 SV=1 von Willebrand factor OS=Homo sapiens OX=9606 341 P04275 VWF 309.262 HUMAN 16.670 43 1.68 0.136 0.001214 1.358 0.034 0.000036 GN=VWF PE=1 SV=4 14 Coagulation factor XIII B chain OS=Homo sapiens 342 P05160 F13B 75.510 HUMAN 32.070 21 0.99 0.219 0.789880 1.359 0.285 0.098429 OX=9606 GN=F13B PE=1 SV=3 A0A075B6 Immunoglobulin heavy variable 4-4 OS=Homo sapiens 343 IGHV4-4 12.848 HUMAN 35.900 8 1.25 0.087 0.015386 1.359 0.090 0.006681 R2 OX=9606 GN=IGHV4-4 PE=3 SV=2 Retinol-binding protein 4 OS=Homo sapiens OX=9606 344 P02753 RBP4 23.010 HUMAN 76.120 29 1.73 0.320 0.058599 1.360 0.303 0.104694 GN=RBP4 PE=1 SV=3 Immunoglobulin gamma-1 heavy chain OS=Homo 345 P0DOX5 IGA2 49.329 HUMAN 71.710 223 1.09 0.096 0.118713 1.361 0.492 0.251998 sapiens OX=9606 PE=1 SV=2 Fibrinogen alpha chain OS=Homo sapiens OX=9606 346 P02671 FGA 94.973 HUMAN 39.610 50 1.05 0.127 0.473428 1.375 0.113 0.003726 GN=FGA PE=1 SV=2 Serum amyloid P-component OS=Homo sapiens 347 P02743 APCS 25.387 HUMAN 41.700 20 1.28 0.161 0.024391 1.385 0.096 0.001650 OX=9606 GN=APCS PE=1 SV=2 HSP90A Heat shock protein HSP 90-beta OS=Homo sapiens 348 P08238 83.264 HUMAN 3.039 3 1.49 0.133 0.002863 1.385 0.135 0.005945 B1 OX=9606 GN=HSP90AB1 PE=1 SV=4 Calponin-2 OS=Homo sapiens OX=9606 GN=CNN2 349 Q99439 CNN2 33.697 HUMAN 5.502 1 1.40 0.149 0.022088 1.391 0.093 0.005886 PE=1 SV=4 Plasma kallikrein OS=Homo sapiens OX=9606 350 P03952 KLKB1 71.369 HUMAN 32.760 26 1.46 0.300 0.063739 1.411 0.242 0.042137 GN=KLKB1 PE=1 SV=1 Apolipoprotein L1 OS=Homo sapiens OX=9606 351 O14791 APOL1 43.974 HUMAN 46.730 28 0.77 0.227 0.043759 1.415 0.041 0.000049 GN=APOL1 PE=1 SV=5 IGHV4- Immunoglobulin heavy variable 4-39 OS=Homo sapiens 352 P01824 13.917 HUMAN 41.600 14 1.37 0.321 0.196862 1.420 0.329 0.165105 39 OX=9606 GN=IGHV4-39 PE=1 SV=2 Immunoglobulin lambda constant 2 OS=Homo sapiens 353 P0DOY2 IGLC2 11.294 HUMAN 93.400 48 0.89 0.266 0.284750 1.428 0.186 0.014347 OX=9606 GN=IGLC2 PE=1 SV=1 Complement C2 OS=Homo sapiens OX=9606 GN=C2 354 P06681 C2 83.267 HUMAN 42.290 28 1.38 0.150 0.007854 1.437 0.066 0.000270 PE=1 SV=2 A0A0C4D IGHV3- Immunoglobulin heavy variable 3-20 OS=Homo sapiens 355 12.673 HUMAN 67.520 56 1.53 0.073 0.000254 1.443 0.026 0.000006 H32 20 OX=9606 GN=IGHV3-20 PE=3 SV=2 Immunoglobulin heavy constant gamma 2 OS=Homo 356 P01859 IGHG2 35.900 HUMAN 74.230 135 0.77 0.170 0.021113 1.452 0.290 0.060175 sapiens OX=9606 GN=IGHG2 PE=1 SV=2 Hemoglobin subunit delta OS=Homo sapiens OX=9606 357 P02042 HBD 16.055 HUMAN 90.480 50 2.25 0.400 0.007459 1.466 0.317 0.049726 GN=HBD PE=1 SV=2 Talin-1 OS=Homo sapiens OX=9606 GN=TLN1 PE=1 358 Q9Y490 TLN1 269.765 HUMAN 6.454 13 2.08 0.157 0.000654 1.470 0.096 0.000875 SV=3 Carbonic anhydrase 2 OS=Homo sapiens OX=9606 359 P00918 CA2 29.246 HUMAN 23.080 4 1.62 0.294 0.015980 1.488 0.421 0.090194 GN=CA2 PE=1 SV=2 HSP90A Heat shock protein HSP 90-alpha OS=Homo sapiens 360 P07900 84.659 HUMAN 6.421 5 1.45 0.097 0.001146 1.509 0.126 0.001783 A1 OX=9606 GN=HSP90AA1 PE=1 SV=5 Protein/nucleic acid deglycase DJ-1 OS=Homo sapiens 361 Q99497 PARK7 19.891 HUMAN 3.704 1 1.69 0.069 0.000636 1.510 0.074 0.001568 OX=9606 GN=PARK7 PE=1 SV=2 Beta-parvin OS=Homo sapiens OX=9606 GN=PARVB 362 Q9HBI1 PARVB 41.714 HUMAN 3.846 1 2.01 0.152 0.002829 1.521 0.140 0.009968 PE=1 SV=1 Peroxiredoxin-6 OS=Homo sapiens OX=9606 363 P30041 PRDX6 25.035 HUMAN 7.143 2 1.91 0.087 0.000693 1.529 0.055 0.000586 GN=PRDX6 PE=1 SV=3 Platelet glycoprotein Ib alpha chain OS=Homo sapiens 364 P07359 GP1BA 71.539 HUMAN 9.509 7 1.37 0.076 0.000802 1.535 0.186 0.005443 OX=9606 GN=GP1BA PE=1 SV=2 Protein S100-A8 OS=Homo sapiens OX=9606 365 P05109 S100A8 10.834 HUMAN 54.840 6 1.05 0.113 0.427276 1.541 0.487 0.107518 GN=S100A8 PE=1 SV=1 Ceruloplasmin OS=Homo sapiens OX=9606 GN=CP 366 P00450 CP 122.204 HUMAN 76.530 320 0.52 0.215 0.002520 1.544 0.253 0.021816 PE=1 SV=1 Kininogen-1 OS=Homo sapiens OX=9606 GN=KNG1 367 P01042 KNG1 71.957 HUMAN 64.440 139 0.74 0.188 0.020072 1.545 0.226 0.015506 PE=1 SV=2 Immunoglobulin lambda variable 3-25 OS=Homo sapiens 368 P01717 IGLV3-25 12.011 HUMAN 36.610 26 1.57 0.223 0.014785 1.551 0.203 0.013614 OX=9606 GN=IGLV3-25 PE=1 SV=2 Complement factor I OS=Homo sapiens OX=9606 369 P05156 CFI 65.750 HUMAN 33.620 27 1.19 0.202 0.147296 1.562 0.234 0.020269 GN=CFI PE=1 SV=2 Coagulation factor XI OS=Homo sapiens OX=9606 370 P03951 F11 70.109 HUMAN 13.280 9 1.16 0.025 0.000171 1.576 0.186 0.009963 GN=F11 PE=1 SV=1 Mannose-binding protein C OS=Homo sapiens OX=9606 371 P11226 MBL2 26.143 HUMAN 45.160 15 1.38 0.144 0.009066 1.591 0.117 0.001022 GN=MBL2 PE=1 SV=2 Immunoglobulin lambda variable 2-11 OS=Homo sapiens 372 P01706 IGLV2-11 12.644 HUMAN 24.370 8 1.65 0.197 0.016388 1.595 0.170 0.012872 OX=9606 GN=IGLV2-11 PE=1 SV=2 Serum amyloid A-2 protein OS=Homo sapiens OX=9606 373 P0DJI9 SAA2 13.527 HUMAN 47.540 22 1.69 0.313 0.026729 1.599 0.310 0.035322 GN=SAA2 PE=1 SV=1 15 Immunoglobulin lambda variable 3-27 OS=Homo sapiens 374 P01718 IGLV3-27 12.165 HUMAN 26.550 4 1.47 0.127 0.009540 1.609 0.101 0.002614 OX=9606 GN=IGLV3-27 PE=1 SV=2 Serotransferrin OS=Homo sapiens OX=9606 GN=TF 375 P02787 TF 77.063 HUMAN 87.110 468 0.59 0.658 0.065344 1.612 0.611 0.293046 PE=1 SV=3 Vitamin D-binding protein OS=Homo sapiens OX=9606 376 P02774 GC 52.917 HUMAN 77.220 84 0.53 0.268 0.005921 1.622 0.281 0.020516 GN=GC PE=1 SV=2 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Homo 377 Q14624 ITIH4 103.357 HUMAN 70.000 175 0.53 0.340 0.013215 1.626 0.195 0.005249 sapiens OX=9606 GN=ITIH4 PE=1 SV=4 Carboxypeptidase N subunit 2 OS=Homo sapiens 378 P22792 CPN2 60.556 HUMAN 23.490 27 0.59 0.449 0.041915 1.627 0.388 0.067566 OX=9606 GN=CPN2 PE=1 SV=3 Thioredoxin OS=Homo sapiens OX=9606 GN=TXN PE=1 379 P10599 TXN 11.737 HUMAN 20.950 2 2.23 0.478 0.078974 1.627 0.446 0.148065 SV=3 Immunoglobulin heavy variable 1-8 OS=Homo sapiens 380 P0DP01 IGHV1-8 12.992 HUMAN 67.520 22 1.35 0.157 0.013068 1.628 0.200 0.006218 OX=9606 GN=IGHV1-8 PE=3 SV=1 Ras-related protein Rab-13 OS=Homo sapiens OX=9606 381 P51153 RAB13 22.774 HUMAN 5.419 1 2.00 0.367 0.041978 1.642 0.384 0.103572 GN=RAB13 PE=1 SV=1 Angiotensinogen OS=Homo sapiens OX=9606 GN=AGT 382 P01019 AGT 53.154 HUMAN 45.360 60 2.00 0.254 0.003631 1.651 0.314 0.037506 PE=1 SV=1 Monocyte differentiation antigen CD14 OS=Homo sapiens 383 P08571 CD14 40.076 HUMAN 26.130 8 0.99 0.383 0.691090 1.662 0.618 0.136102 OX=9606 GN=CD14 PE=1 SV=2 Adiponectin OS=Homo sapiens OX=9606 GN=ADIPOQ 384 Q15848 ADIPOQ 26.414 HUMAN 36.480 15 1.44 0.316 0.090299 1.665 0.130 0.001110 PE=1 SV=1 A0A075B6 Immunoglobulin lambda variable 3-9 OS=Homo sapiens 385 IGLV3-9 12.332 HUMAN 55.650 17 1.24 0.050 0.000728 1.706 0.063 0.000048 K5 OX=9606 GN=IGLV3-9 PE=3 SV=1 Glyceraldehyde-3-phosphate dehydrogenase OS=Homo 386 P04406 GAPDH 36.053 HUMAN 13.130 3 2.29 0.400 0.017818 1.713 0.322 0.024592 sapiens OX=9606 GN=GAPDH PE=1 SV=3 14-3-3 protein zeta/delta OS=Homo sapiens OX=9606 387 P63104 YWHAZ 27.745 HUMAN 13.060 3 1.56 0.206 0.014719 1.735 0.253 0.020199 GN=YWHAZ PE=1 SV=1 Pulmonary surfactant-associated protein B OS=Homo 388 P07988 SFTPB 42.117 HUMAN 2.362 1 1.36 0.060 0.002037 1.739 0.085 0.000990 sapiens OX=9606 GN=SFTPB PE=1 SV=3 IGHV1- Immunoglobulin heavy variable 1-69 OS=Homo sapiens 389 P01742 12.659 HUMAN 70.940 23 2.48 0.466 0.030431 1.742 0.310 0.018409 69 OX=9606 GN=IGHV1-69 PE=1 SV=2 A0A0C4D IGHV1- Immunoglobulin heavy variable 1-18 OS=Homo sapiens 390 12.820 HUMAN 72.650 31 1.55 0.301 0.043830 1.749 0.218 0.006826 H31 18 OX=9606 GN=IGHV1-18 PE=3 SV=1 A0A0C4D IGHV2- Immunoglobulin heavy variable 2-70D OS=Homo sapiens 391 13.312 HUMAN 40.340 4 3.77 0.054 0.000019 1.767 0.045 0.000139 H43 70D OX=9606 GN=IGHV2-70D PE=3 SV=1 Complement component C7 OS=Homo sapiens OX=9606 392 P10643 C7 93.518 HUMAN 45.080 45 2.56 0.478 0.019346 1.768 0.422 0.064058 GN=C7 PE=1 SV=2 IGHV3- Immunoglobulin heavy variable 3-53 OS=Homo sapiens 393 P01767 12.769 HUMAN 56.900 52 1.50 0.124 0.007774 1.811 0.107 0.001596 53 OX=9606 GN=IGHV3-53 PE=1 SV=2 Complement C1r subcomponent OS=Homo sapiens 394 P00736 C1R 80.118 HUMAN 45.390 34 1.35 0.114 0.005938 1.873 0.300 0.027112 OX=9606 GN=C1R PE=1 SV=2 Cathepsin D OS=Homo sapiens OX=9606 GN=CTSD 395 P07339 CTSD 44.552 HUMAN 20.870 7 1.15 0.227 0.309738 1.907 0.124 0.000334 PE=1 SV=1 A0A087W Immunoglobulin lambda variable 5-45 OS=Homo sapiens 396 IGLV5-45 13.162 HUMAN 21.140 2 1.91 0.068 0.000326 1.910 0.077 0.000458 SX0 OX=9606 GN=IGLV5-45 PE=3 SV=1 Pregnancy zone protein OS=Homo sapiens OX=9606 397 P20742 PZP 163.862 HUMAN 30.570 192 2.89 0.227 0.001097 1.920 0.314 0.035477 GN=PZP PE=1 SV=4 Leucine-rich alpha-2-glycoprotein OS=Homo sapiens 398 P02750 LRG1 38.178 HUMAN 57.350 31 1.16 0.097 0.035960 1.989 0.130 0.000451 OX=9606 GN=LRG1 PE=1 SV=2 Hemoglobin subunit mu OS=Homo sapiens OX=9606 399 Q6B0K9 HBM 15.618 HUMAN 10.640 1 2.10 0.331 0.025304 2.158 0.308 0.018824 GN=HBM PE=1 SV=1 Triosephosphate isomerase OS=Homo sapiens OX=9606 400 P60174 TPI1 30.791 HUMAN 11.540 3 2.84 0.169 0.001028 2.193 0.212 0.004589 GN=TPI1 PE=1 SV=3 A0A0C4D IGHV5- Immunoglobulin heavy variable 5-51 OS=Homo sapiens 401 12.674 HUMAN 83.760 20 2.92 0.417 0.005981 2.193 0.309 0.005991 H38 51 OX=9606 GN=IGHV5-51 PE=3 SV=1 Immunoglobulin heavy constant mu OS=Homo sapiens 402 P01871 IGHM 49.439 HUMAN 79.250 237 1.41 0.332 0.177962 2.258 0.334 0.016370 OX=9606 GN=IGHM PE=1 SV=4 Bisphosphoglycerate mutase OS=Homo sapiens 403 P07738 BPGM 30.005 HUMAN 10.810 4 3.11 0.191 0.001368 2.300 0.245 0.006730 OX=9606 GN=BPGM PE=1 SV=2 Cofilin-1 OS=Homo sapiens OX=9606 GN=CFL1 PE=1 404 P23528 CFL1 18.502 HUMAN 43.370 5 2.90 0.226 0.002931 2.307 0.300 0.013455 SV=3 A0A0C4D IGHV1- Immunoglobulin heavy variable 1-24 OS=Homo sapiens 405 12.824 HUMAN 64.100 12 3.85 0.363 0.005413 2.308 0.261 0.005393 H33 24 OX=9606 GN=IGHV1-24 PE=3 SV=1 16 Protein AMBP OS=Homo sapiens OX=9606 GN=AMBP 406 P02760 AMBP 38.999 HUMAN 53.410 24 1.73 0.429 0.068992 2.384 0.429 0.026659 PE=1 SV=1 PDZ and LIM domain protein 1 OS=Homo sapiens 407 O00151 PDLIM1 36.072 HUMAN 3.040 1 1.71 0.069 0.000594 2.407 0.098 0.000380 OX=9606 GN=PDLIM1 PE=1 SV=4 A0A0B4J1 Immunoglobulin heavy variable 6-1 OS=Homo sapiens 408 IGHV6-1 13.481 HUMAN 29.750 8 1.35 0.207 0.042157 2.425 0.231 0.001212 U7 OX=9606 GN=IGHV6-1 PE=3 SV=1 Flavin reductase (NADPH) OS=Homo sapiens OX=9606 409 P30043 BLVRB 22.119 HUMAN 23.300 3 3.47 0.881 0.094763 2.476 0.876 0.240733 GN=BLVRB PE=1 SV=3 A0A0B4J1 IGHV3- Immunoglobulin heavy variable 3-74 OS=Homo sapiens 410 12.840 HUMAN 76.070 44 2.19 0.217 0.002016 2.481 0.100 0.000037 X5 74 OX=9606 GN=IGHV3-74 PE=3 SV=1 Protein S100-A9 OS=Homo sapiens OX=9606 411 P06702 S100A9 13.242 HUMAN 73.680 8 1.46 0.149 0.007084 2.495 0.078 0.000012 GN=S100A9 PE=1 SV=1 Peroxiredoxin-2 OS=Homo sapiens OX=9606 412 P32119 PRDX2 21.892 HUMAN 38.380 10 3.62 0.170 0.000057 2.503 0.246 0.000762 GN=PRDX2 PE=1 SV=5 Complement factor H-related protein 1 OS=Homo sapiens 413 Q03591 CFHR1 37.650 HUMAN 27.270 12 4.56 0.815 0.041913 2.505 0.789 0.132557 OX=9606 GN=CFHR1 PE=1 SV=2 A0A0B4J1 IGHV3- Immunoglobulin heavy variable 3-15 OS=Homo sapiens 414 12.926 HUMAN 59.660 19 2.27 0.275 0.002165 2.514 0.344 0.002737 V0 15 OX=9606 GN=IGHV3-15 PE=3 SV=1 Polyubiquitin-B OS=Homo sapiens OX=9606 GN=UBB 415 P0CG47 UBB 25.762 HUMAN 52.400 4 3.29 0.429 0.013609 2.520 0.388 0.015435 PE=1 SV=1 Immunoglobulin J chain OS=Homo sapiens OX=9606 416 P01591 JCHAIN 18.098 HUMAN 64.150 16 1.79 0.530 0.132387 2.561 0.470 0.022620 GN=JCHAIN PE=1 SV=4 Complement C4-A OS=Homo sapiens OX=9606 GN=C4A 417 P0C0L4 C4A 192.784 HUMAN 71.270 331 2.74 0.320 0.002584 2.582 0.183 0.000302 PE=1 SV=2 Complement component C9 OS=Homo sapiens OX=9606 418 P02748 C9 63.173 HUMAN 37.390 34 1.85 0.212 0.003207 2.588 0.215 0.000661 GN=C9 PE=1 SV=2 Complement factor B OS=Homo sapiens OX=9606 419 P00751 CFB 85.532 HUMAN 56.280 113 1.87 0.411 0.035828 2.618 0.380 0.006031 GN=CFB PE=1 SV=2 Beta-2-glycoprotein 1 OS=Homo sapiens OX=9606 420 P02749 APOH 38.298 HUMAN 43.770 20 5.63 0.513 0.030847 2.667 0.612 0.099147 GN=APOH PE=1 SV=3 Hemoglobin subunit zeta OS=Homo sapiens OX=9606 421 P02008 HBZ 15.637 HUMAN 41.550 6 1.53 0.244 0.020706 2.712 0.131 0.000068 GN=HBZ PE=1 SV=2 Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens 422 P62937 PPIA 18.012 HUMAN 23.030 4 2.22 0.144 0.001655 2.749 0.114 0.000400 OX=9606 GN=PPIA PE=1 SV=2 Actin, cytoplasmic 1 OS=Homo sapiens OX=9606 423 P60709 ACTB 41.736 HUMAN 57.070 23 2.35 0.402 0.011521 2.844 0.396 0.008657 GN=ACTB PE=1 SV=1 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Homo 424 Q06033 ITIH3 99.849 HUMAN 34.040 52 1.43 0.243 0.035070 2.867 0.141 0.000108 sapiens OX=9606 GN=ITIH3 PE=1 SV=2 Fructose-bisphosphate aldolase B OS=Homo sapiens 425 P05062 ALDOB 39.473 HUMAN 19.780 6 1.92 0.249 0.007402 2.916 0.350 0.008083 OX=9606 GN=ALDOB PE=1 SV=2 Apolipoprotein D OS=Homo sapiens OX=9606 426 P05090 APOD 21.275 HUMAN 42.860 22 3.70 0.577 0.010775 2.942 0.547 0.016608 GN=APOD PE=1 SV=1 Immunoglobulin heavy variable 3-9 OS=Homo sapiens 427 P01782 IGHV3-9 12.945 HUMAN 74.580 62 2.21 0.370 0.024661 2.955 0.374 0.015909 OX=9606 GN=IGHV3-9 PE=1 SV=2 A0A075B6 Immunoglobulin lambda variable 5-37 OS=Homo sapiens 428 IGLV5-37 13.277 HUMAN 31.710 2 2.29 0.058 0.000093 3.032 0.102 0.000217 J1 OX=9606 GN=IGLV5-37 PE=3 SV=1 Tropomyosin beta chain OS=Homo sapiens OX=9606 429 P07951 TPM2 32.850 HUMAN 10.560 4 4.67 0.512 0.017494 3.118 0.463 0.019482 GN=TPM2 PE=1 SV=1 Haptoglobin-related protein OS=Homo sapiens OX=9606 430 P00739 HPR 39.029 HUMAN 77.590 154 1.04 0.333 0.945283 3.149 0.313 0.002173 GN=HPR PE=2 SV=2 Immunoglobulin lambda variable 3-19 OS=Homo sapiens 431 P01714 IGLV3-19 12.042 HUMAN 40.180 8 4.16 0.515 0.016498 3.166 0.488 0.023099 OX=9606 GN=IGLV3-19 PE=1 SV=2 Vitronectin OS=Homo sapiens OX=9606 GN=VTN PE=1 432 P04004 VTN 54.305 HUMAN 50.630 43 3.09 0.462 0.006634 3.179 0.528 0.010006 SV=1 Afamin OS=Homo sapiens OX=9606 GN=AFM PE=1 433 P43652 AFM 69.069 HUMAN 45.580 34 4.05 0.647 0.028527 3.290 0.653 0.037476 SV=1 Profilin-1 OS=Homo sapiens OX=9606 GN=PFN1 PE=1 434 P07737 PFN1 15.054 HUMAN 49.290 6 3.45 0.316 0.002340 3.335 0.206 0.000254 SV=2 Plasminogen OS=Homo sapiens OX=9606 GN=PLG 435 P00747 PLG 90.568 HUMAN 57.280 91 2.55 0.425 0.045413 3.444 0.446 0.020842 PE=1 SV=2 A0A075B6 Immunoglobulin lambda variable 3-10 OS=Homo sapiens 436 IGLV3-10 12.441 HUMAN 52.170 14 2.95 0.262 0.004143 3.606 0.246 0.002074 K4 OX=9606 GN=IGLV3-10 PE=3 SV=2 SERPIN Alpha-1-antitrypsin OS=Homo sapiens OX=9606 437 P01009 46.736 HUMAN 88.760 351 0.98 0.656 0.548402 3.613 0.735 0.045725 A1 GN=SERPINA1 PE=1 SV=3 17 Filamin-A OS=Homo sapiens OX=9606 GN=FLNA PE=1 438 P21333 FLNA 280.738 HUMAN 2.909 6 5.16 0.455 0.013604 3.695 0.457 0.015954 SV=4 Leukocyte immunoglobulin-like receptor subfamily A 439 O75019 LILRA1 53.274 HUMAN member 1 OS=Homo sapiens OX=9606 GN=LILRA1 3.681 2 1.68 0.182 0.003148 3.709 0.158 0.000054 PE=2 SV=1 Alpha-1-acid glycoprotein 2 OS=Homo sapiens OX=9606 440 P19652 ORM2 23.602 HUMAN 64.180 38 1.56 0.396 0.114579 3.820 0.457 0.006672 GN=ORM2 PE=1 SV=2 Immunoglobulin lambda variable 2-14 OS=Homo sapiens 441 P01704 IGLV2-14 12.597 HUMAN 28.330 6 2.76 0.158 0.001064 4.014 0.148 0.000344 OX=9606 GN=IGLV2-14 PE=1 SV=2 Polymeric immunoglobulin receptor OS=Homo sapiens 442 P01833 PIGR 83.283 HUMAN 13.350 9 3.37 0.337 0.005751 4.186 0.335 0.002889 OX=9606 GN=PIGR PE=1 SV=4 Hemoglobin subunit alpha OS=Homo sapiens OX=9606 443 P69905 HBA1 15.257 HUMAN 66.900 58 7.10 0.285 0.000162 4.287 0.211 0.000125 GN=HBA1 PE=1 SV=2 CD5 antigen-like OS=Homo sapiens OX=9606 GN=CD5L 444 O43866 CD5L 38.088 HUMAN 60.810 25 2.42 0.600 0.111450 4.389 0.648 0.030809 PE=1 SV=1 Hemoglobin subunit gamma-2 OS=Homo sapiens 445 P69892 HBG2 16.126 HUMAN 74.830 15 1.93 0.364 0.061113 4.574 0.555 0.002157 OX=9606 GN=HBG2 PE=1 SV=2 Complement factor H OS=Homo sapiens OX=9606 446 P08603 CFH 139.095 HUMAN 54.750 131 8.21 0.541 0.008438 4.599 0.492 0.008555 GN=CFH PE=1 SV=4 SERPIN Alpha-1-antichymotrypsin OS=Homo sapiens OX=9606 447 P01011 47.650 HUMAN 76.120 137 1.76 0.703 0.265761 4.834 0.435 0.001793 A3 GN=SERPINA3 PE=1 SV=2 Immunoglobulin lambda variable 3-21 OS=Homo sapiens 448 P80748 IGLV3-21 12.446 HUMAN 64.960 21 5.21 0.101 0.000004 4.925 0.081 0.000002 OX=9606 GN=IGLV3-21 PE=1 SV=2 Prothrombin OS=Homo sapiens OX=9606 GN=F2 PE=1 449 P00734 F2 70.036 HUMAN 58.200 72 6.09 0.484 0.013007 5.579 0.495 0.010396 SV=2 Serum amyloid A-1 protein OS=Homo sapiens OX=9606 450 P0DJI8 SAA1 13.532 HUMAN 63.930 32 2.99 0.497 0.014548 5.868 0.575 0.016039 GN=SAA1 PE=1 SV=1 Transthyretin OS=Homo sapiens OX=9606 GN=TTR 451 P02766 TTR 15.887 HUMAN 86.390 54 7.46 0.556 0.015504 5.904 0.538 0.010904 PE=1 SV=1 Transgelin-2 OS=Homo sapiens OX=9606 GN=TAGLN2 452 P37802 TAGLN2 22.391 HUMAN 26.130 5 6.22 0.519 0.004087 6.024 0.455 0.001935 PE=1 SV=3 HIST1H2 Histone H2A type 1-B/E OS=Homo sapiens OX=9606 453 P04908 14.135 HUMAN 21.540 2 6.16 1.059 0.375952 6.233 1.252 0.559217 AB GN=HIST1H2AB PE=1 SV=2 C4b-binding protein alpha chain OS=Homo sapiens 454 P04003 C4BPA 67.033 HUMAN 47.240 44 7.82 0.492 0.009466 6.268 0.472 0.008651 OX=9606 GN=C4BPA PE=1 SV=2 A0A0B4J1 IGHV3- Immunoglobulin heavy variable 3-43 OS=Homo sapiens 455 13.077 HUMAN 72.880 54 6.40 0.742 0.018126 7.071 0.744 0.016374 X8 43 OX=9606 GN=IGHV3-43 PE=3 SV=1 Hemoglobin subunit beta OS=Homo sapiens OX=9606 456 P68871 HBB 15.998 HUMAN 89.800 73 14.06 0.520 0.000376 8.448 0.605 0.001988 GN=HBB PE=1 SV=2 Immunoglobulin heavy constant gamma 3 OS=Homo 457 P01860 IGHG3 41.287 HUMAN 75.600 101 8.59 0.549 0.016821 9.212 0.518 0.007682 sapiens OX=9606 GN=IGHG3 PE=1 SV=2 Hemoglobin subunit gamma-1 OS=Homo sapiens 458 P69891 HBG1 16.140 HUMAN 74.830 15 9.04 0.755 0.008630 9.847 0.670 0.002185 OX=9606 GN=HBG1 PE=1 SV=2 C4b-binding protein beta chain OS=Homo sapiens 459 P20851 C4BPB 28.357 HUMAN 23.810 7 11.65 0.669 0.019129 10.667 0.671 0.018923 OX=9606 GN=C4BPB PE=1 SV=1 Alpha-1-acid glycoprotein 1 OS=Homo sapiens OX=9606 460 P02763 ORM1 23.511 HUMAN 72.140 77 6.43 0.453 0.007377 11.280 0.406 0.001205 GN=ORM1 PE=1 SV=1 Alpha-2-HS-glycoprotein OS=Homo sapiens OX=9606 461 P02765 AHSG 39.340 HUMAN 73.570 116 11.45 0.557 0.054446 13.610 0.541 0.027812 GN=AHSG PE=1 SV=2 Haptoglobin OS=Homo sapiens OX=9606 GN=HP PE=1 462 P00738 HP 45.205 HUMAN 95.320 407 16.78 0.528 0.015758 22.467 0.535 0.014884 SV=1 C-reactive protein OS=Homo sapiens OX=9606 GN=CRP 463 P02741 CRP 25.038 HUMAN 14.290 4 12.53 0.329 0.000209 23.288 0.362 0.000187 PE=1 SV=1

18 Table S2. Coefficient of variation (CV) and fold-change of quantified proteins in RSV acute/convalescence phase vs control.

CV Acute phase vs Control Convalescence phase vs Control

< 0.1 117(25.27%) 186(40.17%)

< 0.2 303(65.44%) 303(65.44%)

< 0.3 365(78.83%) 372(80.35%)

< 0.4 405(87.47%) 414(89.42%)

< 0.5 430(92.87%) 439(94.82%)

< 0.6 448(96.76%) 448(96.76%)

< 0.7 454(98.06%) 457(98.7%)

Fold change value

< 1.2 (0.833 ~ 1.2) 206(44.49%) 214(46.22%)

< 1.5 (0.667 - 1.5) 316(68.25%) 326(70.41%)

< 2.0 (0.5 - 2.0) 380(82.07%) 385(83.15%)

< 2.5 ( 0.25 - 2.5) 419(90.50%) 411(88.77%)

Table S3. Differentially expressed proteins in children with respiratory syncytial virus infection in acute-phase vs control.

Citable accession Gene name Mass (kDa) Species Name %Cov (95) Peptides (95%) Fold change CV P value Immunoglobulin alpha-2 heavy chain P0DOX2 IGG1 48,934 HUMAN OS=Homo sapiens OX=9606 PE=1 53,630 76 0.362 0.405 0.010343 SV=2 Apolipoprotein A-IV OS=Homo sapiens P06727 APOA4 45,399 HUMAN 85,610 124 0.257 0.261 0.000346 OX=9606 GN=APOA4 PE=1 SV=3 Keratin, type I cytoskeletal 10 OS=Homo P13645 KRT10 58,827 HUMAN sapiens OX=9606 GN=KRT10 PE=1 23,290 16 0.371 0.155 0.000117 SV=6 Fibronectin OS=Homo sapiens OX=9606 P02751 FN1 262,623 HUMAN 59,560 251 0.465 0.097 0.000052 GN=FN1 PE=1 SV=4 Immunoglobulin heavy constant gamma P01861 IGHG4 35,940 HUMAN 4 OS=Homo sapiens OX=9606 71,870 142 0.244 0.214 0.000141 GN=IGHG4 PE=1 SV=1 19 Dipeptidyl peptidase 4 OS=Homo P27487 DPP4 88,278 HUMAN sapiens OX=9606 GN=DPP4 PE=1 6,789 4 0.440 0.210 0.000893 SV=2 Beta-Ala-His dipeptidase OS=Homo Q96KN2 CNDP1 56,706 HUMAN sapiens OX=9606 GN=CNDP1 PE=1 27,420 12 0.289 0.062 0.000001 SV=4 Coagulation factor XIII A chain P00488 F13A1 83,267 HUMAN OS=Homo sapiens OX=9606 GN=F13A1 17,080 12 0.474 0.245 0.001485 PE=1 SV=4 Alkaline phosphatase, tissue-nonspecific P05186 ALPL 57,304 HUMAN isozyme OS=Homo sapiens OX=9606 6,107 3 0.425 0.331 0.010691 GN=ALPL PE=1 SV=4 Zinc-alpha-2-glycoprotein OS=Homo P25311 AZGP1 34,259 HUMAN sapiens OX=9606 GN=AZGP1 PE=1 57,720 44 0.435 0.154 0.000262 SV=2 Keratin, type II cytoskeletal 1 OS=Homo P04264 KRT1 66,039 HUMAN 28,730 24 0.500 0.163 0.000596 sapiens OX=9606 GN=KRT1 PE=1 SV=6 Inter-alpha-trypsin inhibitor heavy chain P19823 ITIH2 106,463 HUMAN H2 OS=Homo sapiens OX=9606 49,680 114 0.492 0.270 0.003998 GN=ITIH2 PE=1 SV=2 Sex hormone-binding globulin OS=Homo P04278 SHBG 43,779 HUMAN sapiens OX=9606 GN=SHBG PE=1 54,480 21 0.478 0.102 0.000093 SV=2 Histidine-rich glycoprotein OS=Homo P04196 HRG 59,578 HUMAN 45,710 35 0.391 0.165 0.000241 sapiens OX=9606 GN=HRG PE=1 SV=1 Heparin cofactor 2 OS=Homo sapiens P05546 SERPIND1 57,070 HUMAN 63,530 67 0.449 0.485 0.014014 OX=9606 GN=SERPIND1 PE=1 SV=3 Immunoglobulin heavy constant delta P01880 IGHD 42,353 HUMAN OS=Homo sapiens OX=9606 GN=IGHD 30,990 16 0.375 0.220 0.000462 PE=1 SV=3 Complement C5 OS=Homo sapiens P01031 C5 188,304 HUMAN 32,280 58 2.136 0.070 0.000017 OX=9606 GN=C5 PE=1 SV=4 Apolipoprotein M OS=Homo sapiens O95445 APOM 21,253 HUMAN 53,720 17 2.010 0.338 0.023471 OX=9606 GN=APOM PE=1 SV=2 Immunoglobulin heavy constant alpha 1 P01876 IGHA1 37,654 HUMAN OS=Homo sapiens OX=9606 GN=IGHA1 81,300 109 0.411 0.272 0.003751 PE=1 SV=2 Lipopolysaccharide-binding protein P18428 LBP 53,383 HUMAN OS=Homo sapiens OX=9606 GN=LBP 14,760 6 2.143 0.307 0.010750 PE=1 SV=3 20 Band 3 anion transport protein OS=Homo P02730 SLC4A1 101,791 HUMAN sapiens OX=9606 GN=SLC4A1 PE=1 4,171 3 3.784 0.119 0.000022 SV=3 Hemoglobin subunit delta OS=Homo P02042 HBD 16,055 HUMAN 90,480 50 2.253 0.400 0.007459 sapiens OX=9606 GN=HBD PE=1 SV=2 Talin-1 OS=Homo sapiens OX=9606 Q9Y490 TLN1 269,765 HUMAN 6,454 13 2.077 0.157 0.000654 GN=TLN1 PE=1 SV=3 Beta-parvin OS=Homo sapiens OX=9606 Q9HBI1 PARVB 41,714 HUMAN 3,846 1 2.013 0.152 0.002829 GN=PARVB PE=1 SV=1 Angiotensinogen OS=Homo sapiens P01019 AGT 53,154 HUMAN 45,360 60 2.000 0.254 0.003631 OX=9606 GN=AGT PE=1 SV=1 Glyceraldehyde-3-phosphate P04406 GAPDH 36,053 HUMAN dehydrogenase OS=Homo sapiens 13,130 3 2.285 0.400 0.017818 OX=9606 GN=GAPDH PE=1 SV=3 Immunoglobulin heavy variable 1-69 P01742 IGHV1-69 12,659 HUMAN OS=Homo sapiens OX=9606 70,940 23 2.478 0.466 0.030431 GN=IGHV1-69 PE=1 SV=2 Immunoglobulin heavy variable 2-70D A0A0C4DH43 IGHV2-70D 13,312 HUMAN OS=Homo sapiens OX=9606 40,340 4 3.771 0.054 0.000019 GN=IGHV2-70D PE=3 SV=1 Complement component C7 OS=Homo P10643 C7 93,518 HUMAN 45,080 45 2.561 0.478 0.019346 sapiens OX=9606 GN=C7 PE=1 SV=2 Pregnancy zone protein OS=Homo P20742 PZP 163,862 HUMAN 30,570 192 2.892 0.227 0.001097 sapiens OX=9606 GN=PZP PE=1 SV=4 Hemoglobin subunit mu OS=Homo Q6B0K9 HBM 15,618 HUMAN 10,640 1 2.100 0.331 0.025304 sapiens OX=9606 GN=HBM PE=1 SV=1 Triosephosphate isomerase OS=Homo P60174 TPI1 30,791 HUMAN 11,540 3 2.838 0.169 0.001028 sapiens OX=9606 GN=TPI1 PE=1 SV=3 Immunoglobulin heavy variable 5-51 A0A0C4DH38 IGHV5-51 12,674 HUMAN OS=Homo sapiens OX=9606 83,760 20 2.917 0.417 0.005981 GN=IGHV5-51 PE=3 SV=1 Bisphosphoglycerate mutase OS=Homo P07738 BPGM 30,005 HUMAN sapiens OX=9606 GN=BPGM PE=1 10,810 4 3.113 0.191 0.001368 SV=2 Cofilin-1 OS=Homo sapiens OX=9606 P23528 CFL1 18,502 HUMAN 43,370 5 2.899 0.226 0.002931 GN=CFL1 PE=1 SV=3 Immunoglobulin heavy variable 1-24 A0A0C4DH33 IGHV1-24 12,824 HUMAN OS=Homo sapiens OX=9606 64,100 12 3.850 0.363 0.005413 GN=IGHV1-24 PE=3 SV=1 Immunoglobulin heavy variable 3-74 A0A0B4J1X5 IGHV3-74 12,840 HUMAN OS=Homo sapiens OX=9606 76,070 44 2.186 0.217 0.002016 GN=IGHV3-74 PE=3 SV=1 21 Peroxiredoxin-2 OS=Homo sapiens P32119 PRDX2 21,892 HUMAN 38,380 10 3.623 0.170 0.000057 OX=9606 GN=PRDX2 PE=1 SV=5 Immunoglobulin heavy variable 3-15 A0A0B4J1V0 IGHV3-15 12,926 HUMAN OS=Homo sapiens OX=9606 59,660 19 2.273 0.275 0.002165 GN=IGHV3-15 PE=3 SV=1 Polyubiquitin-B OS=Homo sapiens P0CG47 UBB 25,762 HUMAN 52,400 4 3.291 0.429 0.013609 OX=9606 GN=UBB PE=1 SV=1 Complement C4-A OS=Homo sapiens P0C0L4 C4A 192,784 HUMAN 71,270 331 2.741 0.320 0.002584 OX=9606 GN=C4A PE=1 SV=2 Peptidyl-prolyl cis-trans isomerase A P62937 PPIA 18,012 HUMAN OS=Homo sapiens OX=9606 GN=PPIA 23,030 4 2.215 0.144 0.001655 PE=1 SV=2 Actin, cytoplasmic 1 OS=Homo sapiens P60709 ACTB 41,736 HUMAN 57,070 23 2.345 0.402 0.011521 OX=9606 GN=ACTB PE=1 SV=1 Immunoglobulin heavy variable 3-9 P01782 IGHV3-9 12,945 HUMAN OS=Homo sapiens OX=9606 74,580 62 2.214 0.370 0.024661 GN=IGHV3-9 PE=1 SV=2 Immunoglobulin lambda variable 5-37 A0A075B6J1 IGLV5-37 13,277 HUMAN OS=Homo sapiens OX=9606 31,710 2 2.294 0.058 0.000093 GN=IGLV5-37 PE=3 SV=1 Vitronectin OS=Homo sapiens OX=9606 P04004 VTN 54,305 HUMAN 50,630 43 3.094 0.462 0.006634 GN=VTN PE=1 SV=1 Profilin-1 OS=Homo sapiens OX=9606 P07737 PFN1 15,054 HUMAN 49,290 6 3.449 0.316 0.002340 GN=PFN1 PE=1 SV=2 Plasminogen OS=Homo sapiens P00747 PLG 90,568 HUMAN 57,280 91 2.547 0.425 0.045413 OX=9606 GN=PLG PE=1 SV=2 Immunoglobulin lambda variable 3-10 A0A075B6K4 IGLV3-10 12,441 HUMAN OS=Homo sapiens OX=9606 52,170 14 2.954 0.262 0.004143 GN=IGLV3-10 PE=3 SV=2 Filamin-A OS=Homo sapiens OX=9606 P21333 FLNA 280,738 HUMAN 2,909 6 5.160 0.455 0.013604 GN=FLNA PE=1 SV=4 Immunoglobulin lambda variable 2-14 P01704 IGLV2-14 12,597 HUMAN OS=Homo sapiens OX=9606 28,330 6 2.755 0.158 0.001064 GN=IGLV2-14 PE=1 SV=2 Polymeric immunoglobulin receptor P01833 PIGR 83,283 HUMAN OS=Homo sapiens OX=9606 GN=PIGR 13,350 9 3.367 0.337 0.005751 PE=1 SV=4 Hemoglobin subunit alpha OS=Homo P69905 HBA1 15,257 HUMAN sapiens OX=9606 GN=HBA1 PE=1 66,900 58 7.098 0.285 0.000162 SV=2 22 Immunoglobulin lambda variable 3-21 P80748 IGLV3-21 12,446 HUMAN OS=Homo sapiens OX=9606 64,960 21 5.213 0.101 0.000004 GN=IGLV3-21 PE=1 SV=2 Prothrombin OS=Homo sapiens P00734 F2 70,036 HUMAN 58,200 72 6.089 0.484 0.013007 OX=9606 GN=F2 PE=1 SV=2 Serum amyloid A-1 protein OS=Homo P0DJI8 SAA1 13,532 HUMAN 63,930 32 2.987 0.497 0.014548 sapiens OX=9606 GN=SAA1 PE=1 SV=1 C4b-binding protein alpha chain P04003 C4BPA 67,033 HUMAN OS=Homo sapiens OX=9606 47,240 44 7.817 0.492 0.009466 GN=C4BPA PE=1 SV=2 Alpha-1-acid glycoprotein 1 OS=Homo P02763 ORM1 23,511 HUMAN sapiens OX=9606 GN=ORM1 PE=1 72,140 77 6.433 0.453 0.007377 SV=1 C-reactive protein OS=Homo sapiens P02741 CRP 25,038 HUMAN 14,290 4 12.528 0.329 0.000209 OX=9606 GN=CRP PE=1 SV=1

Cov: %Cov(95) is the sequence coverage from identified peptides having confidence greater than or equal to 95%.

Table S4. Differentially expressed proteins in children with respiratory syncytial virus infection in convalescence-phase vs control.

Citable accession Gene name Mass (kDa) Species Name %Cov (95) Peptides (95%) Fold change CV P value Immunoglobulin alpha-2 heavy chain P0DOX2 IGG1 48,934 HUMAN OS=Homo sapiens OX=9606 PE=1 53,630 76 0.299 0.263 0.000541 SV=2 Apolipoprotein A-IV OS=Homo sapiens P06727 APOA4 45,399 HUMAN 85,610 124 0.340 0.201 0.000299 OX=9606 GN=APOA4 PE=1 SV=3 Apolipoprotein C-I OS=Homo sapiens P02654 APOC1 9,332 HUMAN 51,810 17 0.403 0.241 0.001019 OX=9606 GN=APOC1 PE=1 SV=1 Fibronectin OS=Homo sapiens OX=9606 P02751 FN1 262,623 HUMAN 59,560 251 0.408 0.136 0.000095 GN=FN1 PE=1 SV=4 Immunoglobulin heavy constant gamma P01861 IGHG4 35,940 HUMAN 4 OS=Homo sapiens OX=9606 71,870 142 0.412 0.099 0.000037 GN=IGHG4 PE=1 SV=1 Dipeptidyl peptidase 4 OS=Homo P27487 DPP4 88,278 HUMAN sapiens OX=9606 GN=DPP4 PE=1 6,789 4 0.413 0.134 0.000128 SV=2 Beta-Ala-His dipeptidase OS=Homo Q96KN2 CNDP1 56,706 HUMAN sapiens OX=9606 GN=CNDP1 PE=1 27,420 12 0.452 0.100 0.000071 SV=4 23 Coagulation factor XIII A chain P00488 F13A1 83,267 HUMAN OS=Homo sapiens OX=9606 GN=F13A1 17,080 12 0.457 0.106 0.000077 PE=1 SV=4 Alkaline phosphatase, tissue-nonspecific P05186 ALPL 57,304 HUMAN isozyme OS=Homo sapiens OX=9606 6,107 3 0.460 0.215 0.002192 GN=ALPL PE=1 SV=4 Zinc-alpha-2-glycoprotein OS=Homo P25311 AZGP1 34,259 HUMAN sapiens OX=9606 GN=AZGP1 PE=1 57,720 44 0.463 0.392 0.006060 SV=2 Phospholipid transfer protein OS=Homo P55058 PLTP 54,739 HUMAN 29,210 15 0.485 0.246 0.004244 sapiens OX=9606 GN=PLTP PE=1 SV=1 Hemoglobin subunit mu OS=Homo Q6B0K9 HBM 15,618 HUMAN 10,640 1 2.158 0.308 0.018824 sapiens OX=9606 GN=HBM PE=1 SV=1 Triosephosphate isomerase OS=Homo P60174 TPI1 30,791 HUMAN 11,540 3 2.193 0.212 0.004589 sapiens OX=9606 GN=TPI1 PE=1 SV=3 Immunoglobulin heavy variable 5-51 A0A0C4DH38 IGHV5-51 12,674 HUMAN OS=Homo sapiens OX=9606 83,760 20 2.193 0.309 0.005991 GN=IGHV5-51 PE=3 SV=1 Immunoglobulin heavy constant mu P01871 IGHM 49,439 HUMAN OS=Homo sapiens OX=9606 GN=IGHM 79,250 237 2.258 0.334 0.016370 PE=1 SV=4 Bisphosphoglycerate mutase OS=Homo P07738 BPGM 30,005 HUMAN sapiens OX=9606 GN=BPGM PE=1 10,810 4 2.300 0.245 0.006730 SV=2 Cofilin-1 OS=Homo sapiens OX=9606 P23528 CFL1 18,502 HUMAN 43,370 5 2.307 0.300 0.013455 GN=CFL1 PE=1 SV=3 Immunoglobulin heavy variable 1-24 A0A0C4DH33 IGHV1-24 12,824 HUMAN OS=Homo sapiens OX=9606 64,100 12 2.308 0.261 0.005393 GN=IGHV1-24 PE=3 SV=1 Protein AMBP OS=Homo sapiens P02760 AMBP 38,999 HUMAN 53,410 24 2.384 0.429 0.026659 OX=9606 GN=AMBP PE=1 SV=1 Immunoglobulin heavy variable 6-1 A0A0B4J1U7 IGHV6-1 13,481 HUMAN OS=Homo sapiens OX=9606 29,750 8 2.425 0.231 0.001212 GN=IGHV6-1 PE=3 SV=1 Immunoglobulin heavy variable 3-74 A0A0B4J1X5 IGHV3-74 12,840 HUMAN OS=Homo sapiens OX=9606 76,070 44 2.481 0.100 0.000037 GN=IGHV3-74 PE=3 SV=1 Protein S100-A9 OS=Homo sapiens P06702 S100A9 13,242 HUMAN 73,680 8 2.495 0.078 0.000012 OX=9606 GN=S100A9 PE=1 SV=1 Peroxiredoxin-2 OS=Homo sapiens P32119 PRDX2 21,892 HUMAN 38,380 10 2.503 0.246 0.000762 OX=9606 GN=PRDX2 PE=1 SV=5 24 Immunoglobulin heavy variable 3-15 A0A0B4J1V0 IGHV3-15 12,926 HUMAN OS=Homo sapiens OX=9606 59,660 19 2.514 0.344 0.002737 GN=IGHV3-15 PE=3 SV=1 Polyubiquitin-B OS=Homo sapiens P0CG47 UBB 25,762 HUMAN 52,400 4 2.520 0.388 0.015435 OX=9606 GN=UBB PE=1 SV=1 Immunoglobulin J chain OS=Homo P01591 JCHAIN 18,098 HUMAN sapiens OX=9606 GN=JCHAIN PE=1 64,150 16 2.561 0.470 0.022620 SV=4 Complement C4-A OS=Homo sapiens P0C0L4 C4A 192,784 HUMAN 71,270 331 2.582 0.183 0.000302 OX=9606 GN=C4A PE=1 SV=2 Complement component C9 OS=Homo P02748 C9 63,173 HUMAN 37,390 34 2.588 0.215 0.000661 sapiens OX=9606 GN=C9 PE=1 SV=2 Complement factor B OS=Homo sapiens P00751 CFB 85,532 HUMAN 56,280 113 2.618 0.380 0.006031 OX=9606 GN=CFB PE=1 SV=2 Hemoglobin subunit zeta OS=Homo P02008 HBZ 15,637 HUMAN 41,550 6 2.712 0.131 0.000068 sapiens OX=9606 GN=HBZ PE=1 SV=2 Peptidyl-prolyl cis-trans isomerase A P62937 PPIA 18,012 HUMAN OS=Homo sapiens OX=9606 GN=PPIA 23,030 4 2.749 0.114 0.000400 PE=1 SV=2 Actin, cytoplasmic 1 OS=Homo sapiens P60709 ACTB 41,736 HUMAN 57,070 23 2.844 0.396 0.008657 OX=9606 GN=ACTB PE=1 SV=1 Inter-alpha-trypsin inhibitor heavy chain Q06033 ITIH3 99,849 HUMAN H3 OS=Homo sapiens OX=9606 34,040 52 2.867 0.141 0.000108 GN=ITIH3 PE=1 SV=2 Fructose-bisphosphate aldolase B P05062 ALDOB 39,473 HUMAN OS=Homo sapiens OX=9606 19,780 6 2.916 0.350 0.008083 GN=ALDOB PE=1 SV=2 Immunoglobulin heavy variable 3-9 P01782 IGHV3-9 12,945 HUMAN OS=Homo sapiens OX=9606 74,580 62 2.955 0.374 0.015909 GN=IGHV3-9 PE=1 SV=2 Immunoglobulin lambda variable 5-37 A0A075B6J1 IGLV5-37 13,277 HUMAN OS=Homo sapiens OX=9606 31,710 2 3.032 0.102 0.000217 GN=IGLV5-37 PE=3 SV=1 Tropomyosin beta chain OS=Homo P07951 TPM2 32,850 HUMAN sapiens OX=9606 GN=TPM2 PE=1 10,560 4 3.118 0.463 0.019482 SV=1 Haptoglobin-related protein OS=Homo P00739 HPR 39,029 HUMAN 77,590 154 3.149 0.313 0.002173 sapiens OX=9606 GN=HPR PE=2 SV=2 Immunoglobulin lambda variable 3-19 P01714 IGLV3-19 12,042 HUMAN OS=Homo sapiens OX=9606 40,180 8 3.166 0.488 0.023099 GN=IGLV3-19 PE=1 SV=2 25 Profilin-1 OS=Homo sapiens OX=9606 P07737 PFN1 15,054 HUMAN 49,290 6 3.335 0.206 0.000254 GN=PFN1 PE=1 SV=2 Plasminogen OS=Homo sapiens P00747 PLG 90,568 HUMAN 57,280 91 3.444 0.446 0.020842 OX=9606 GN=PLG PE=1 SV=2 Immunoglobulin lambda variable 3-10 A0A075B6K4 IGLV3-10 12,441 HUMAN OS=Homo sapiens OX=9606 52,170 14 3.606 0.246 0.002074 GN=IGLV3-10 PE=3 SV=2 Filamin-A OS=Homo sapiens OX=9606 P21333 FLNA 280,738 HUMAN 2,909 6 3.695 0.457 0.015954 GN=FLNA PE=1 SV=4 Leukocyte immunoglobulin-like receptor subfamily A member 1 OS=Homo O75019 LILRA1 53,274 HUMAN 3,681 2 3.709 0.158 0.000054 sapiens OX=9606 GN=LILRA1 PE=2 SV=1 Alpha-1-acid glycoprotein 2 OS=Homo P19652 ORM2 23,602 HUMAN sapiens OX=9606 GN=ORM2 PE=1 64,180 38 3.820 0.457 0.006672 SV=2 Immunoglobulin lambda variable 2-14 P01704 IGLV2-14 12,597 HUMAN OS=Homo sapiens OX=9606 28,330 6 4.014 0.148 0.000344 GN=IGLV2-14 PE=1 SV=2 Polymeric immunoglobulin receptor P01833 PIGR 83,283 HUMAN OS=Homo sapiens OX=9606 GN=PIGR 13,350 9 4.186 0.335 0.002889 PE=1 SV=4 Hemoglobin subunit alpha OS=Homo P69905 HBA1 15,257 HUMAN sapiens OX=9606 GN=HBA1 PE=1 66,900 58 4.287 0.211 0.000125 SV=2 Complement factor H OS=Homo sapiens P08603 CFH 139,095 HUMAN 54,750 131 4.599 0.492 0.008555 OX=9606 GN=CFH PE=1 SV=4 Alpha-1-antichymotrypsin OS=Homo P01011 SERPINA3 47,650 HUMAN sapiens OX=9606 GN=SERPINA3 PE=1 76,120 137 4.834 0.435 0.001793 SV=2 Immunoglobulin lambda variable 3-21 P80748 IGLV3-21 12,446 HUMAN OS=Homo sapiens OX=9606 64,960 21 4.925 0.081 0.000002 GN=IGLV3-21 PE=1 SV=2 Prothrombin OS=Homo sapiens P00734 F2 70,036 HUMAN 58,200 72 5.579 0.495 0.010396 OX=9606 GN=F2 PE=1 SV=2 Transgelin-2 OS=Homo sapiens P37802 TAGLN2 22,391 HUMAN 26,130 5 6.024 0.455 0.001935 OX=9606 GN=TAGLN2 PE=1 SV=3 C4b-binding protein alpha chain P04003 C4BPA 67,033 HUMAN OS=Homo sapiens OX=9606 47,240 44 6.268 0.472 0.008651 GN=C4BPA PE=1 SV=2 26 Alpha-1-acid glycoprotein 1 OS=Homo P02763 ORM1 23,511 HUMAN sapiens OX=9606 GN=ORM1 PE=1 72,140 77 11.280 0.406 0.001205 SV=1 C-reactive protein OS=Homo sapiens P02741 CRP 25,038 HUMAN 14,290 4 23.288 0.362 0.000187 OX=9606 GN=CRP PE=1 SV=1

%Cov(95) is the sequence coverage from identified peptides having confidence greater than or equal to 95%.

Table S5. The protein classification of DEPs.

Protein Class Acute vs control (%) Convalescence vs control (%)

intercellular signal molecule (PC00207) 2.80% 2.90%

defense/immunity protein (PC00090) 38.90% 42.90%

cytoskeletal protein (PC00085) 11.10% 14.30%

protein-binding activity modulator (PC00095) 19.40% 8.60%

metabolite interconversion enzyme (PC00262) 13.90% 11.40%

protein modifying enzyme (PC00260) 11.10% 14.30%

transporter (PC00227) 2.80% 0.00%

transfer/carrier protein (PC00219) 0.00% 2.90%

calcium-binding protein (PC00060) 0.00% 2.90%

Table S6. GO enrichment analysis of each MCODE network components.

Log Category PARENT_ Log Enrich- Z- #TotalGen #Gene #GeneI #GeneInGO %In STDV Gene Name Category GO Description Hits (q- ID GO (P) ment score eInLibrary InGO nHitList AndHitList GO %InGO ID value) 19_GO:00 Acute phase GO 669|25 GO:00 canonical 08152 - 3.40E+0 BPGM|GAPDH| vs control Biological 19 32 24398 27 8 3 38 17 97|716 -4.9 61621 glycolysis metabolic 7.2 2 TPI1 MCODE 1 Processes 7 process glucose 19_GO:00 Acute phase GO 669|25 GO:00 catabolic 08152 - 3.40E+0 BPGM|GAPDH| vs control Biological 19 32 24398 27 8 3 38 17 97|716 -4.9 61718 process to metabolic 7.2 2 TPI1 MCODE 1 Processes 7 pyruvate process 19_GO:00 Acute phase GO NADH 669|25 GO:00 08152 - 3.40E+0 BPGM|GAPDH| vs control Biological 19 regeneratio 32 24398 27 8 3 38 17 97|716 -4.9 06735 metabolic 7.2 2 TPI1 MCODE 1 Processes n 7 process 19_GO:00 Acute phase GO glycolytic 669|25 GO:00 08152 - 3.30E+0 BPGM|GAPDH| vs control Biological 19 process 31 24398 28 8 3 38 17 97|716 -4.9 61620 metabolic 7.1 2 TPI1 MCODE 1 Processes through 7 process 27 glucose-6- phosphate glycolytic 19_GO:00 Acute phase GO process 669|25 GO:00 08152 - 3.20E+0 BPGM|GAPDH| vs control Biological 19 through 31 24398 29 8 3 38 17 97|716 -4.9 61615 metabolic 7.1 2 TPI1 MCODE 1 Processes fructose-6- 7 process phosphate 19_GO:00 Acute phase GO glucose 669|25 GO:00 08152 - 2.50E+0 BPGM|GAPDH| vs control Biological 19 catabolic 28 24398 36 8 3 38 17 97|716 -4.6 06007 metabolic 6.8 2 TPI1 MCODE 1 Processes process 7 process 19_GO:00 Acute phase GO NADH 669|25 GO:00 08152 - 2.20E+0 BPGM|GAPDH| vs control Biological 19 metabolic 25 24398 42 8 3 38 17 97|716 -4.5 06734 metabolic 6.6 2 TPI1 MCODE 1 Processes process 7 process 19_GO:00 Acute phase GO NAD 669|25 GO:00 08152 - 1.60E+0 BPGM|GAPDH| vs control Biological 19 biosynthetic 22 24398 56 8 3 38 17 97|716 -4.2 09435 metabolic 6.2 2 TPI1 MCODE 1 Processes process 7 process 19_GO:00 Acute phase GO hexose 669|25 GO:00 08152 - 1.60E+0 BPGM|GAPDH| vs control Biological 19 catabolic 22 24398 57 8 3 38 17 97|716 -4.2 19320 metabolic 6.2 2 TPI1 MCODE 1 Processes process 7 process monosacch 19_GO:00 Acute phase GO 669|25 GO:00 aride 08152 1.40E+0 BPGM|GAPDH| vs control Biological 19 -6 20 24398 67 8 3 38 17 97|716 -4 46365 catabolic metabolic 2 TPI1 MCODE 1 Processes 7 process process 19_GO:00 Acute phase GO NAD 669|25 GO:00 08152 - 1.20E+0 BPGM|GAPDH| vs control Biological 19 metabolic 19 24398 77 8 3 38 17 97|716 -3.8 19674 metabolic 5.8 2 TPI1 MCODE 1 Processes process 7 process 19_GO:00 Acute phase GO interaction 51704 1072|2 GO:00 - 1.00E+0 CFL1|FN1|GAP vs control Biological 19 with multi- 17 24398 91 8 3 38 17 335|25 -3.6 51702 5.6 2 DH MCODE 1 Processes symbiont organism 97 process 19_GO:00 regulation of 1072|2 Acute phase GO 51704 GO:00 multi- - 597|54 CFL1|GAPDH| vs control Biological 19 multi- 30 11 24398 412 8 4 50 18 -3.4 43900 organism 5.3 78|700 PPIA|PRDX2 MCODE 1 Processes organism process 1 process 19_GO:00 Acute phase GO 669|25 GO:00 glycolytic 08152 - BPGM|GAPDH| vs control Biological 19 80 15 24398 115 8 3 38 17 97|716 -3.4 06096 process metabolic 5.3 TPI1 MCODE 1 Processes 7 process 19_GO:00 Acute phase GO ATP 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 generation 79 15 24398 116 8 3 38 17 97|716 -3.4 06757 metabolic 5.2 TPI1 MCODE 1 Processes from ADP 7 process 19_GO:00 Acute phase GO pyruvate 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 biosynthetic 77 15 24398 119 8 3 38 17 97|716 -3.4 42866 metabolic 5.2 TPI1 MCODE 1 Processes process 7 process 19_GO:00 Acute phase GO ADP 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 metabolic 72 15 24398 127 8 3 38 17 97|716 -3.3 46031 metabolic 5.1 TPI1 MCODE 1 Processes process 7 process nucleoside 19_GO:00 Acute phase GO 669|25 GO:00 diphosphate 08152 - BPGM|GAPDH| vs control Biological 19 68 14 24398 134 8 3 38 17 97|716 -3.3 06165 phosphoryla metabolic 5.1 TPI1 MCODE 1 Processes 7 tion process Acute phase GO nucleotide 669|25 GO:00 19_GO:00 BPGM|GAPDH| vs control Biological 19 phosphoryla -5 67 14 24398 136 8 3 38 17 97|716 -3.3 46939 08152 TPI1 MCODE 1 Processes tion 7 28 metabolic process purine ribonucleosi 19_GO:00 Acute phase GO 669|25 GO:00 de 08152 BPGM|GAPDH| vs control Biological 19 -5 66 14 24398 139 8 3 38 17 97|716 -3.2 09179 diphosphate metabolic TPI1 MCODE 1 Processes 7 metabolic process process purine 19_GO:00 Acute phase GO nucleoside 669|25 GO:00 08152 BPGM|GAPDH| vs control Biological 19 diphosphate -5 66 14 24398 139 8 3 38 17 97|716 -3.2 09135 metabolic TPI1 MCODE 1 Processes metabolic 7 process process ribonucleosi 19_GO:00 Acute phase GO de 669|25 GO:00 08152 BPGM|GAPDH| vs control Biological 19 diphosphate -5 65 14 24398 141 8 3 38 17 97|716 -3.2 09185 metabolic TPI1 MCODE 1 Processes metabolic 7 process process nicotinamid 19_GO:00 Acute phase GO 669|25 GO:00 e nucleotide 08152 - BPGM|GAPDH| vs control Biological 19 62 13 24398 147 8 3 38 17 97|716 -3.2 19359 biosynthetic metabolic 4.9 TPI1 MCODE 1 Processes 7 process process pyridine 19_GO:00 Acute phase GO 669|25 GO:00 nucleotide 08152 - BPGM|GAPDH| vs control Biological 19 62 13 24398 147 8 3 38 17 97|716 -3.2 19363 biosynthetic metabolic 4.9 TPI1 MCODE 1 Processes 7 process process pyridine- 19_GO:00 Acute phase GO containing 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 compound 61 13 24398 150 8 3 38 17 97|716 -3.2 72525 metabolic 4.9 TPI1 MCODE 1 Processes biosynthetic 7 process process 19_GO:00 Acute phase GO pyruvate 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 metabolic 59 13 24398 155 8 3 38 17 97|716 -3.1 06090 metabolic 4.9 TPI1 MCODE 1 Processes process 7 process nucleoside 19_GO:00 Acute phase GO 669|25 GO:00 diphosphate 08152 - BPGM|GAPDH| vs control Biological 19 58 13 24398 159 8 3 38 17 97|716 -3.1 09132 metabolic metabolic 4.8 TPI1 MCODE 1 Processes 7 process process 19_GO:00 Acute phase GO ATP 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 biosynthetic 57 13 24398 160 8 3 38 17 97|716 -3.1 06754 metabolic 4.8 TPI1 MCODE 1 Processes process 7 process Acute phase GO 669|54 GO:00 isomerase - BPGM|PPIA|TP vs control Molecular 21 54 13 24398 168 8 3 38 17 78|716 -3.1 16853 activity 4.8 I1 MCODE 1 Functions 7 purine ribonucleosi 19_GO:00 Acute phase GO 669|25 GO:00 de 08152 - BPGM|GAPDH| vs control Biological 19 54 12 24398 171 8 3 38 17 97|716 -3 09206 triphosphate metabolic 4.7 TPI1 MCODE 1 Processes 7 biosynthetic process process purine 19_GO:00 Acute phase GO nucleoside 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 triphosphate 53 12 24398 172 8 3 38 17 97|716 -3 09145 metabolic 4.7 TPI1 MCODE 1 Processes biosynthetic 7 process process ribonucleosi 19_GO:00 Acute phase GO de 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 triphosphate 52 12 24398 177 8 3 38 17 97|716 -3 09201 metabolic 4.7 TPI1 MCODE 1 Processes biosynthetic 7 process process 29 purine ribonucleosi 19_GO:00 Acute phase GO de 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 monophosp 50 12 24398 183 8 3 38 17 97|716 -3 09168 metabolic 4.6 TPI1 MCODE 1 Processes hate 7 process biosynthetic process purine nucleoside 19_GO:00 Acute phase GO 669|25 GO:00 monophosp 08152 - BPGM|GAPDH| vs control Biological 19 50 12 24398 183 8 3 38 17 97|716 -3 09127 hate metabolic 4.6 TPI1 MCODE 1 Processes 7 biosynthetic process process 19_GO:00 Acute phase GO nucleotide 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 catabolic 50 12 24398 184 8 3 38 17 97|716 -3 09166 metabolic 4.6 TPI1 MCODE 1 Processes process 7 process positive 19_GO:00 Acute phase GO regulation of 51704 1072|2 GO:00 - CFL1|GAPDH| vs control Biological 19 multi- multi- 49 12 24398 186 8 3 38 17 597|54 -3 43902 4.6 PPIA MCODE 1 Processes organism organism 78 process process nucleoside 19_GO:00 Acute phase GO 669|25 GO:00 triphosphate 08152 - BPGM|GAPDH| vs control Biological 19 49 12 24398 188 8 3 38 17 97|716 -3 09142 biosynthetic metabolic 4.6 TPI1 MCODE 1 Processes 7 process process 19_GO:00 Acute phase GO cofactor 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 metabolic 20 8.6 24398 609 8 4 50 18 97|700 -2.9 51186 metabolic 4.6 PRDX2|TPI1 MCODE 1 Processes process 1|7167 process nucleoside 19_GO:00 Acute phase GO 669|25 GO:19 phosphate 08152 - BPGM|GAPDH| vs control Biological 19 48 12 24398 190 8 3 38 17 97|716 -2.9 01292 catabolic metabolic 4.6 TPI1 MCODE 1 Processes 7 process process nicotinamid 19_GO:00 Acute phase GO 669|25 GO:00 e nucleotide 08152 - BPGM|GAPDH| vs control Biological 19 48 12 24398 192 8 3 38 17 97|716 -2.9 46496 metabolic metabolic 4.6 TPI1 MCODE 1 Processes 7 process process pyridine 19_GO:00 Acute phase GO 669|25 GO:00 nucleotide 08152 - BPGM|GAPDH| vs control Biological 19 48 12 24398 192 8 3 38 17 97|716 -2.9 19362 metabolic metabolic 4.6 TPI1 MCODE 1 Processes 7 process process ribonucleosi de 19_GO:00 Acute phase GO 669|25 GO:00 monophosp 08152 - BPGM|GAPDH| vs control Biological 19 46 12 24398 197 8 3 38 17 97|716 -2.9 09156 hate metabolic 4.6 TPI1 MCODE 1 Processes 7 biosynthetic process process pyridine- 19_GO:00 Acute phase GO containing 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 compound 46 12 24398 199 8 3 38 17 97|716 -2.9 72524 metabolic 4.5 TPI1 MCODE 1 Processes metabolic 7 process process 19_GO:00 Acute phase GO carbohydrat 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 e catabolic 46 12 24398 200 8 3 38 17 97|716 -2.9 16052 metabolic 4.5 TPI1 MCODE 1 Processes process 7 process nucleoside 19_GO:00 Acute phase GO monophosp 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 hate 44 11 24398 208 8 3 38 17 97|716 -2.9 09124 metabolic 4.5 TPI1 MCODE 1 Processes biosynthetic 7 process process 30 oxidoreducti 19_GO:00 Acute phase GO on 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 coenzyme 43 11 24398 211 8 3 38 17 97|716 -2.8 06733 metabolic 4.5 TPI1 MCODE 1 Processes metabolic 7 process process 19_GO:00 Acute phase GO glucose 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 metabolic 43 11 24398 213 8 3 38 17 97|716 -2.8 06006 metabolic 4.4 TPI1 MCODE 1 Processes process 7 process regulation of symbiosis, 19_GO:00 Acute phase GO encompassi 51704 1072|2 GO:00 - CFL1|GAPDH| vs control Biological 19 ng multi- 41 11 24398 225 8 3 38 17 597|54 -2.8 43903 4.4 PPIA MCODE 1 Processes mutualism organism 78 through process parasitism nucleobase- containing 19_GO:00 Acute phase GO 669|25 GO:00 small 08152 - BPGM|GAPDH| vs control Biological 19 40 11 24398 227 8 3 38 17 97|716 -2.8 34404 molecule metabolic 4.4 TPI1 MCODE 1 Processes 7 biosynthetic process process organophos 19_GO:00 Acute phase GO 669|25 GO:00 phate 08152 - BPGM|GAPDH| vs control Biological 19 37 10 24398 249 8 3 38 17 97|716 -2.7 46434 catabolic metabolic 4.2 TPI1 MCODE 1 Processes 7 process process 19_GO:00 Acute phase GO hexose 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 metabolic 36 10 24398 253 8 3 38 17 97|716 -2.7 19318 metabolic 4.2 TPI1 MCODE 1 Processes process 7 process 19_GO:00 Acute phase GO coenzyme 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 biosynthetic 35 10 24398 260 8 3 38 17 97|716 -2.6 09108 metabolic 4.2 TPI1 MCODE 1 Processes process 7 process purine 19_GO:00 Acute phase GO ribonucleoti 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 de 33 9.7 24398 279 8 3 38 17 97|716 -2.5 09152 metabolic 4.1 TPI1 MCODE 1 Processes biosynthetic 7 process process ribonucleoti 19_GO:00 Acute phase GO 669|25 GO:00 de 08152 BPGM|GAPDH| vs control Biological 19 -4 31 9.4 24398 292 8 3 38 17 97|716 -2.5 09260 biosynthetic metabolic TPI1 MCODE 1 Processes 7 process process monosacch 19_GO:00 Acute phase GO 669|25 GO:00 aride 08152 BPGM|GAPDH| vs control Biological 19 -4 31 9.4 24398 295 8 3 38 17 97|716 -2.5 05996 metabolic metabolic TPI1 MCODE 1 Processes 7 process process ribose 19_GO:00 Acute phase GO 669|25 GO:00 phosphate 08152 BPGM|GAPDH| vs control Biological 19 -4 31 9.3 24398 299 8 3 38 17 97|716 -2.5 46390 biosynthetic metabolic TPI1 MCODE 1 Processes 7 process process purine 19_GO:00 Acute phase GO 669|25 GO:00 nucleotide 08152 BPGM|GAPDH| vs control Biological 19 -4 30 9.3 24398 300 8 3 38 17 97|716 -2.5 06164 biosynthetic metabolic TPI1 MCODE 1 Processes 7 process process 19_GO:00 Acute phase GO ATP 669|25 GO:00 08152 BPGM|GAPDH| vs control Biological 19 metabolic -4 30 9.2 24398 306 8 3 38 17 97|716 -2.5 46034 metabolic TPI1 MCODE 1 Processes process 7 process purine- 19_GO:00 Acute phase GO containing 669|25 GO:00 08152 BPGM|GAPDH| vs control Biological 19 compound -4 29 9.1 24398 313 8 3 38 17 97|716 -2.4 72522 metabolic TPI1 MCODE 1 Processes biosynthetic 7 process process 31 19_GO:00 Acute phase GO cofactor 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 biosynthetic 28 8.9 24398 324 8 3 38 17 97|716 -2.4 51188 metabolic 3.9 TPI1 MCODE 1 Processes process 7 process purine ribonucleosi 19_GO:00 Acute phase GO 669|25 GO:00 de 08152 - BPGM|GAPDH| vs control Biological 19 27 8.8 24398 335 8 3 38 17 97|716 -2.4 09205 triphosphate metabolic 3.9 TPI1 MCODE 1 Processes 7 metabolic process process ribonucleosi 19_GO:00 Acute phase GO de 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 triphosphate 27 8.7 24398 341 8 3 38 17 97|716 -2.4 09199 metabolic 3.8 TPI1 MCODE 1 Processes metabolic 7 process process monocarbox 19_GO:00 Acute phase GO 669|25 GO:00 ylic acid 08152 - BPGM|GAPDH| vs control Biological 19 27 8.7 24398 341 8 3 38 17 97|716 -2.4 72330 biosynthetic metabolic 3.8 TPI1 MCODE 1 Processes 7 process process purine ribonucleosi 19_GO:00 Acute phase GO de 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 monophosp 27 8.7 24398 342 8 3 38 17 97|716 -2.4 09167 metabolic 3.8 TPI1 MCODE 1 Processes hate 7 process metabolic process purine 19_GO:00 Acute phase GO nucleoside 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 triphosphate 27 8.7 24398 342 8 3 38 17 97|716 -2.4 09144 metabolic 3.8 TPI1 MCODE 1 Processes metabolic 7 process process purine nucleoside 19_GO:00 Acute phase GO 669|25 GO:00 monophosp 08152 - BPGM|GAPDH| vs control Biological 19 27 8.7 24398 343 8 3 38 17 97|716 -2.4 09126 hate metabolic 3.8 TPI1 MCODE 1 Processes 7 metabolic process process ribonucleosi de 19_GO:00 Acute phase GO 669|25 GO:00 monophosp 08152 - BPGM|GAPDH| vs control Biological 19 26 8.5 24398 356 8 3 38 17 97|716 -2.3 09161 hate metabolic 3.8 TPI1 MCODE 1 Processes 7 metabolic process process nucleoside 19_GO:00 Acute phase GO 669|25 GO:00 triphosphate 08152 - BPGM|GAPDH| vs control Biological 19 25 8.4 24398 362 8 3 38 17 97|716 -2.3 09141 metabolic metabolic 3.8 TPI1 MCODE 1 Processes 7 process process nucleoside 19_GO:00 Acute phase GO monophosp 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 hate 24 8.2 24398 377 8 3 38 17 97|716 -2.3 09123 metabolic 3.7 TPI1 MCODE 1 Processes metabolic 7 process process 19_GO:00 Acute phase GO nucleotide 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 biosynthetic 24 8.2 24398 385 8 3 38 17 97|716 -2.2 09165 metabolic 3.7 TPI1 MCODE 1 Processes process 7 process nucleoside 19_GO:00 Acute phase GO 669|25 GO:19 phosphate 08152 - BPGM|GAPDH| vs control Biological 19 24 8.1 24398 389 8 3 38 17 97|716 -2.2 01293 biosynthetic metabolic 3.7 TPI1 MCODE 1 Processes 7 process process 19_GO:00 Acute phase GO coenzyme 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 metabolic 22 7.9 24398 407 8 3 38 17 97|716 -2.2 06732 metabolic 3.6 TPI1 MCODE 1 Processes process 7 process 32 Acute phase GO Cellular GO:00 focal - 60|107 ACTB|CFL1|PP vs control Component 20 22 7.9 24398 410 8 3 38 17 -2.2 05925 adhesion 3.6 2|5478 IA MCODE 1 s cell- Acute phase GO Cellular GO:00 substrate - 60|107 ACTB|CFL1|PP vs control Component 20 22 7.9 24398 413 8 3 38 17 -2.2 05924 adherens 3.6 2|5478 IA MCODE 1 s junction Acute phase GO Cellular cell- GO:00 - 60|107 ACTB|CFL1|PP vs control Component 20 substrate 22 7.8 24398 417 8 3 38 17 -2.2 30055 3.6 2|5478 IA MCODE 1 s junction small 19_GO:00 Acute phase GO 669|25 GO:00 molecule 08152 - BPGM|GAPDH| vs control Biological 19 21 7.5 24398 445 8 3 38 17 97|716 -2.1 44282 catabolic metabolic 3.5 TPI1 MCODE 1 Processes 7 process process carboxylic 19_GO:00 Acute phase GO 669|25 GO:00 acid 08152 - BPGM|GAPDH| vs control Biological 19 20 7.4 24398 462 8 3 38 17 97|716 -2 46394 biosynthetic metabolic 3.5 TPI1 MCODE 1 Processes 7 process process 19_GO:00 Acute phase GO organic acid 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 biosynthetic 20 7.4 24398 463 8 3 38 17 97|716 -2 16053 metabolic 3.5 TPI1 MCODE 1 Processes process 7 process 19_GO:00 Acute phase GO regulation of 2335|2 GO:00 51179 - FN1|GAPDH|P vs control Biological 19 protein 19 7.1 24398 492 8 3 38 17 597|54 -2 50708 localizatio 3.4 PIA MCODE 1 Processes secretion 78 n 19_GO:00 Acute phase GO regulation of 2335|2 GO:00 51179 - FN1|GAPDH|P vs control Biological 19 peptide 18 6.9 24398 520 8 3 38 17 597|54 -1.9 02791 localizatio 3.3 PIA MCODE 1 Processes secretion 78 n generation 19_GO:00 Acute phase GO 669|25 GO:00 of precursor 08152 - BPGM|GAPDH| vs control Biological 19 18 6.9 24398 522 8 3 38 17 97|716 -1.9 06091 metabolites metabolic 3.3 TPI1 MCODE 1 Processes 7 and energy process purine 19_GO:00 Acute phase GO ribonucleoti 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 de 17 6.8 24398 543 8 3 38 17 97|716 -1.9 09150 metabolic 3.2 TPI1 MCODE 1 Processes metabolic 7 process process Acute phase GO Cellular GO:00 adherens - 60|107 ACTB|CFL1|PP vs control Component 20 17 6.7 24398 549 8 3 38 17 -1.9 05912 junction 3.2 2|5478 IA MCODE 1 s ribonucleoti 19_GO:00 Acute phase GO 669|25 GO:00 de 08152 - BPGM|GAPDH| vs control Biological 19 16 6.7 24398 558 8 3 38 17 97|716 -1.9 09259 metabolic metabolic 3.2 TPI1 MCODE 1 Processes 7 process process Acute phase GO Cellular GO:00 anchoring - 60|107 ACTB|CFL1|PP vs control Component 20 16 6.6 24398 565 8 3 38 17 -1.8 70161 junction 3.2 2|5478 IA MCODE 1 s 19_GO:00 Acute phase GO 50896 GO:00 wound - 60|233 ACTB|FN1|PR vs control Biological 19 response 16 6.5 24398 576 8 3 38 17 -1.8 42060 healing 3.2 5|7001 DX2 MCODE 1 Processes to stimulus purine 19_GO:00 Acute phase GO 669|25 GO:00 nucleotide 08152 - BPGM|GAPDH| vs control Biological 19 16 6.5 24398 577 8 3 38 17 97|716 -1.8 06163 metabolic metabolic 3.2 TPI1 MCODE 1 Processes 7 process process ribose 19_GO:00 Acute phase GO 669|25 GO:00 phosphate 08152 - BPGM|GAPDH| vs control Biological 19 16 6.5 24398 578 8 3 38 17 97|716 -1.8 19693 metabolic metabolic 3.2 TPI1 MCODE 1 Processes 7 process process 33 cell morphogen 19_GO:00 Acute phase GO esis 32502 GO:00 - 60|107 ACTB|CFL1|FN vs control Biological 19 involved in developm 15 6.4 24398 598 8 3 38 17 -1.8 48667 3.1 2|2335 1 MCODE 1 Processes neuron ental differentiatio process n purine- 19_GO:00 Acute phase GO containing 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 compound 15 6.3 24398 613 8 3 38 17 97|716 -1.8 72521 metabolic 3.1 TPI1 MCODE 1 Processes metabolic 7 process process 19_GO:00 Acute phase GO 2335|2 GO:00 protein 51179 - FN1|GAPDH|P vs control Biological 19 15 6.3 24398 614 8 3 38 17 597|54 -1.8 09306 secretion localizatio 3.1 PIA MCODE 1 Processes 78 n 19_GO:00 Acute phase GO carbohydrat 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 e metabolic 15 6.2 24398 629 8 3 38 17 97|716 -1.7 05975 metabolic 3.1 TPI1 MCODE 1 Processes process 7 process 19_GO:00 Acute phase GO 2335|2 GO:00 peptide 51179 FN1|GAPDH|P vs control Biological 19 -3 14 6.1 24398 649 8 3 38 17 597|54 -1.7 02790 secretion localizatio PIA MCODE 1 Processes 78 n monocarbox 19_GO:00 Acute phase GO 669|25 GO:00 ylic acid 08152 BPGM|GAPDH| vs control Biological 19 -3 14 6.1 24398 651 8 3 38 17 97|716 -1.7 32787 metabolic metabolic TPI1 MCODE 1 Processes 7 process process 19_GO:00 neuron Acute phase GO 32502 GO:00 projection 60|107 ACTB|CFL1|FN vs control Biological 19 developm -3 14 6.1 24398 658 8 3 38 17 -1.7 48812 morphogen 2|2335 1 MCODE 1 Processes ental esis process nucleobase- 19_GO:00 Acute phase GO containing 669|25 GO:00 08152 BPGM|GAPDH| vs control Biological 19 compound -3 14 6 24398 664 8 3 38 17 97|716 -1.7 34655 metabolic TPI1 MCODE 1 Processes catabolic 7 process process plasma membrane 19_GO:00 Acute phase GO bounded 32502 GO:01 60|107 ACTB|CFL1|FN vs control Biological 19 cell developm -3 14 6 24398 672 8 3 38 17 -1.7 20039 2|2335 1 MCODE 1 Processes projection ental morphogen process esis 19_GO:00 cell Acute phase GO 32502 GO:00 projection 60|107 ACTB|CFL1|FN vs control Biological 19 developm -3 14 6 24398 676 8 3 38 17 -1.7 48858 morphogen 2|2335 1 MCODE 1 Processes ental esis process 19_GO:00 Acute phase GO 50896 GO:00 response to - 60|233 ACTB|FN1|PR vs control Biological 19 response 13 5.9 24398 691 8 3 38 17 -1.6 09611 wounding 2.9 5|7001 DX2 MCODE 1 Processes to stimulus 19_GO:00 Acute phase GO cell part 32502 GO:00 - 60|107 ACTB|CFL1|FN vs control Biological 19 morphogen developm 13 5.9 24398 696 8 3 38 17 -1.6 32990 2.9 2|2335 1 MCODE 1 Processes esis ental process organophos 19_GO:00 Acute phase GO 669|25 GO:00 phate 08152 - BPGM|GAPDH| vs control Biological 19 13 5.9 24398 700 8 3 38 17 97|716 -1.6 90407 biosynthetic metabolic 2.9 TPI1 MCODE 1 Processes 7 process process 34 19_GO:00 Acute phase GO nucleotide 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 metabolic 13 5.8 24398 710 8 3 38 17 97|716 -1.6 09117 metabolic 2.9 TPI1 MCODE 1 Processes process 7 process nucleoside 19_GO:00 Acute phase GO 669|25 GO:00 phosphate 08152 - BPGM|GAPDH| vs control Biological 19 13 5.8 24398 717 8 3 38 17 97|716 -1.6 06753 metabolic metabolic 2.9 TPI1 MCODE 1 Processes 7 process process 19_GO:00 Acute phase GO heterocycle 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 catabolic 13 5.8 24398 717 8 3 38 17 97|716 -1.6 46700 metabolic 2.9 TPI1 MCODE 1 Processes process 7 process cellular 19_GO:00 Acute phase GO nitrogen 669|25 GO:00 08152 - BPGM|GAPDH| vs control Biological 19 compound 13 5.8 24398 718 8 3 38 17 97|716 -1.6 44270 metabolic 2.9 TPI1 MCODE 1 Processes catabolic 7 process process 19_GO:00 Acute phase GO regulation of 2335|2 GO:00 51179 - FN1|GAPDH|P vs control Biological 19 protein 13 5.8 24398 725 8 3 38 17 597|54 -1.6 51223 localizatio 2.9 PIA MCODE 1 Processes transport 78 n aromatic 19_GO:00 Acute phase GO 669|25 GO:00 compound 08152 - BPGM|GAPDH| vs control Biological 19 13 5.7 24398 730 8 3 38 17 97|716 -1.6 19439 catabolic metabolic 2.9 TPI1 MCODE 1 Processes 7 process process 19_GO:00 Acute phase GO regulation of 2335|2 GO:00 51179 - FN1|GAPDH|P vs control Biological 19 peptide 12 5.6 24398 755 8 3 38 17 597|54 -1.6 90087 localizatio 2.8 PIA MCODE 1 Processes transport 78 n cell 19_GO:00 morphogen Acute phase GO 32502 GO:00 esis - 60|107 ACTB|CFL1|FN vs control Biological 19 developm 12 5.6 24398 756 8 3 38 17 -1.6 00904 involved in 2.8 2|2335 1 MCODE 1 Processes ental differentiatio process n organic 19_GO:00 Acute phase GO cyclic 669|25 GO:19 08152 - BPGM|GAPDH| vs control Biological 19 compound 12 5.6 24398 768 8 3 38 17 97|716 -1.5 01361 metabolic 2.8 TPI1 MCODE 1 Processes catabolic 7 process process regulation of 19_GO:00 Acute phase GO 2335|2 GO:00 establishme 51179 - FN1|GAPDH|P vs control Biological 19 12 5.5 24398 772 8 3 38 17 597|54 -1.5 70201 nt of protein localizatio 2.8 PIA MCODE 1 Processes 78 localization n carbohydrat 19_GO:00 Acute phase GO 669|25 GO:19 e derivative 08152 - BPGM|GAPDH| vs control Biological 19 12 5.5 24398 774 8 3 38 17 97|716 -1.5 01137 biosynthetic metabolic 2.8 TPI1 MCODE 1 Processes 7 process process 19_GO:00 Acute phase GO regulation of 2335|2 GO:19 51179 - FN1|GAPDH|P vs control Biological 19 secretion by 12 5.5 24398 777 8 3 38 17 597|54 -1.5 03530 localizatio 2.8 PIA MCODE 1 Processes cell 78 n cytokine- Acute phase GO 19_GO:00 1072|2 GO:00 mediated - CFL1|FN1|PPI vs control Biological 19 23052 11 5.5 24398 796 8 3 38 17 335|54 -1.5 19221 signaling 2.8 A MCODE 1 Processes signaling 78 pathway

Convalesce GO 669|54 GO:00 isomerase BPGM|PPIA|TP nce phase Molecular 21 -5 62 13 24398 168 7 3 43 19 78|716 -3.2 16853 activity I1 vs control Functions 7 MCODE 1 GO 19_GO:00 1072|5 GO:00 regulation of - CFL1|PPIA|PR Convalesce Biological 19 51704 25 8.5 24398 412 7 3 43 19 478|70 -2.3 43900 multi- 3.8 DX2 nce phase Processes multi- 01 35 vs control organism organism MCODE 1 process process

19_GO:00 Convalesce GO cofactor 669|70 GO:00 08152 - BPGM|PRDX2| nce phase Biological 19 metabolic 17 6.8 24398 609 7 3 43 19 01|716 -1.9 51186 metabolic 3.3 TPI1 vs control Processes process 7 process MCODE 1

19_GO:00 Convalesce GO 2335|5 GO:00 regulated 51179 FN1|PPIA|TAG nce phase Biological 19 -3 13 5.9 24398 796 7 3 43 19 478|84 -1.7 45055 exocytosis localizatio LN2 vs control Processes 07 n MCODE 1

cytokine- Convalesce GO 19_GO:00 1072|2 GO:00 mediated CFL1|FN1|PPI nce phase Biological 19 23052 -3 13 5.9 24398 796 7 3 43 19 335|54 -1.7 19221 signaling A vs control Processes signaling 78 pathway MCODE 1 RSV 19_GO:00 GO 669|25 infection vs GO:00 canonical 08152 - 3.40E+0 BPGM|GAPDH| Biological 19 32 24398 27 8 3 38 17 97|716 -4.9 control 61621 glycolysis metabolic 7.2 2 TPI1 Processes 7 MCODE 1 process RSV 19_GO:00 GO NADH 669|25 infection vs GO:00 08152 - 3.40E+0 BPGM|GAPDH| Biological 19 regeneratio 32 24398 27 8 3 38 17 97|716 -4.9 control 06735 metabolic 7.2 2 TPI1 Processes n 7 MCODE 1 process RSV glucose 19_GO:00 GO 669|25 infection vs GO:00 catabolic 08152 - 3.40E+0 BPGM|GAPDH| Biological 19 32 24398 27 8 3 38 17 97|716 -4.9 control 61718 process to metabolic 7.2 2 TPI1 Processes 7 MCODE 1 pyruvate process glycolytic RSV 19_GO:00 GO process 669|25 infection vs GO:00 08152 - 3.30E+0 BPGM|GAPDH| Biological 19 through 31 24398 28 8 3 38 17 97|716 -4.9 control 61620 metabolic 7.1 2 TPI1 Processes glucose-6- 7 MCODE 1 process phosphate glycolytic RSV 19_GO:00 GO process 669|25 infection vs GO:00 08152 - 3.20E+0 BPGM|GAPDH| Biological 19 through 31 24398 29 8 3 38 17 97|716 -4.9 control 61615 metabolic 7.1 2 TPI1 Processes fructose-6- 7 MCODE 1 process phosphate RSV 19_GO:00 GO glucose 669|25 infection vs GO:00 08152 - 2.50E+0 BPGM|GAPDH| Biological 19 catabolic 28 24398 36 8 3 38 17 97|716 -4.6 control 06007 metabolic 6.8 2 TPI1 Processes process 7 MCODE 1 process RSV 19_GO:00 GO NADH 669|25 infection vs GO:00 08152 - 2.20E+0 BPGM|GAPDH| Biological 19 metabolic 25 24398 42 8 3 38 17 97|716 -4.5 control 06734 metabolic 6.6 2 TPI1 Processes process 7 MCODE 1 process RSV 19_GO:00 GO NAD 669|25 infection vs GO:00 08152 - 1.60E+0 BPGM|GAPDH| Biological 19 biosynthetic 22 24398 56 8 3 38 17 97|716 -4.2 control 09435 metabolic 6.2 2 TPI1 Processes process 7 MCODE 1 process RSV 19_GO:00 GO hexose 669|25 infection vs GO:00 08152 - 1.60E+0 BPGM|GAPDH| Biological 19 catabolic 22 24398 57 8 3 38 17 97|716 -4.2 control 19320 metabolic 6.2 2 TPI1 Processes process 7 MCODE 1 process RSV monosacch 19_GO:00 GO 669|25 infection vs GO:00 aride 08152 1.40E+0 BPGM|GAPDH| Biological 19 -6 20 24398 67 8 3 38 17 97|716 -4 control 46365 catabolic metabolic 2 TPI1 Processes 7 MCODE 1 process process RSV 19_GO:00 GO NAD 669|25 infection vs GO:00 08152 - 1.20E+0 BPGM|GAPDH| Biological 19 metabolic 19 24398 77 8 3 38 17 97|716 -3.8 control 19674 metabolic 5.8 2 TPI1 Processes process 7 MCODE 1 process 36 19_GO:00 RSV GO interaction 51704 1072|2 infection vs GO:00 - 1.00E+0 CFL1|FN1|GAP Biological 19 with multi- 17 24398 91 8 3 38 17 335|25 -3.6 control 51702 5.6 2 DH Processes symbiont organism 97 MCODE 1 process 19_GO:00 RSV regulation of 1072|2 GO 51704 infection vs GO:00 multi- - 597|54 CFL1|GAPDH| Biological 19 multi- 30 11 24398 412 8 4 50 18 -3.4 control 43900 organism 5.3 78|700 PPIA|PRDX2 Processes organism MCODE 1 process 1 process RSV 19_GO:00 GO 669|25 infection vs GO:00 glycolytic 08152 - BPGM|GAPDH| Biological 19 80 15 24398 115 8 3 38 17 97|716 -3.4 control 06096 process metabolic 5.3 TPI1 Processes 7 MCODE 1 process RSV 19_GO:00 GO ATP 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 generation 79 15 24398 116 8 3 38 17 97|716 -3.4 control 06757 metabolic 5.2 TPI1 Processes from ADP 7 MCODE 1 process RSV 19_GO:00 GO pyruvate 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 biosynthetic 77 15 24398 119 8 3 38 17 97|716 -3.4 control 42866 metabolic 5.2 TPI1 Processes process 7 MCODE 1 process RSV 19_GO:00 GO ADP 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 metabolic 72 15 24398 127 8 3 38 17 97|716 -3.3 control 46031 metabolic 5.1 TPI1 Processes process 7 MCODE 1 process RSV nucleoside 19_GO:00 GO 669|25 infection vs GO:00 diphosphate 08152 - BPGM|GAPDH| Biological 19 68 14 24398 134 8 3 38 17 97|716 -3.3 control 06165 phosphoryla metabolic 5.1 TPI1 Processes 7 MCODE 1 tion process RSV 19_GO:00 GO nucleotide 669|25 infection vs GO:00 08152 BPGM|GAPDH| Biological 19 phosphoryla -5 67 14 24398 136 8 3 38 17 97|716 -3.3 control 46939 metabolic TPI1 Processes tion 7 MCODE 1 process purine RSV ribonucleosi 19_GO:00 GO 669|25 infection vs GO:00 de 08152 BPGM|GAPDH| Biological 19 -5 66 14 24398 139 8 3 38 17 97|716 -3.2 control 09179 diphosphate metabolic TPI1 Processes 7 MCODE 1 metabolic process process purine RSV 19_GO:00 GO nucleoside 669|25 infection vs GO:00 08152 BPGM|GAPDH| Biological 19 diphosphate -5 66 14 24398 139 8 3 38 17 97|716 -3.2 control 09135 metabolic TPI1 Processes metabolic 7 MCODE 1 process process ribonucleosi RSV 19_GO:00 GO de 669|25 infection vs GO:00 08152 BPGM|GAPDH| Biological 19 diphosphate -5 65 14 24398 141 8 3 38 17 97|716 -3.2 control 09185 metabolic TPI1 Processes metabolic 7 MCODE 1 process process RSV nicotinamid 19_GO:00 GO 669|25 infection vs GO:00 e nucleotide 08152 - BPGM|GAPDH| Biological 19 62 13 24398 147 8 3 38 17 97|716 -3.2 control 19359 biosynthetic metabolic 4.9 TPI1 Processes 7 MCODE 1 process process RSV pyridine 19_GO:00 GO 669|25 infection vs GO:00 nucleotide 08152 - BPGM|GAPDH| Biological 19 62 13 24398 147 8 3 38 17 97|716 -3.2 control 19363 biosynthetic metabolic 4.9 TPI1 Processes 7 MCODE 1 process process pyridine- RSV 19_GO:00 GO containing 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 compound 61 13 24398 150 8 3 38 17 97|716 -3.2 control 72525 metabolic 4.9 TPI1 Processes biosynthetic 7 MCODE 1 process process 37 RSV 19_GO:00 GO pyruvate 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 metabolic 59 13 24398 155 8 3 38 17 97|716 -3.1 control 06090 metabolic 4.9 TPI1 Processes process 7 MCODE 1 process RSV nucleoside 19_GO:00 GO 669|25 infection vs GO:00 diphosphate 08152 - BPGM|GAPDH| Biological 19 58 13 24398 159 8 3 38 17 97|716 -3.1 control 09132 metabolic metabolic 4.8 TPI1 Processes 7 MCODE 1 process process RSV 19_GO:00 GO ATP 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 biosynthetic 57 13 24398 160 8 3 38 17 97|716 -3.1 control 06754 metabolic 4.8 TPI1 Processes process 7 MCODE 1 process RSV GO 669|54 infection vs GO:00 isomerase - BPGM|PPIA|TP Molecular 21 54 13 24398 168 8 3 38 17 78|716 -3.1 control 16853 activity 4.8 I1 Functions 7 MCODE 1 purine RSV ribonucleosi 19_GO:00 GO 669|25 infection vs GO:00 de 08152 - BPGM|GAPDH| Biological 19 54 12 24398 171 8 3 38 17 97|716 -3 control 09206 triphosphate metabolic 4.7 TPI1 Processes 7 MCODE 1 biosynthetic process process purine RSV 19_GO:00 GO nucleoside 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 triphosphate 53 12 24398 172 8 3 38 17 97|716 -3 control 09145 metabolic 4.7 TPI1 Processes biosynthetic 7 MCODE 1 process process ribonucleosi RSV 19_GO:00 GO de 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 triphosphate 52 12 24398 177 8 3 38 17 97|716 -3 control 09201 metabolic 4.7 TPI1 Processes biosynthetic 7 MCODE 1 process process purine ribonucleosi RSV 19_GO:00 GO de 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 monophosp 50 12 24398 183 8 3 38 17 97|716 -3 control 09168 metabolic 4.6 TPI1 Processes hate 7 MCODE 1 process biosynthetic process purine RSV nucleoside 19_GO:00 GO 669|25 infection vs GO:00 monophosp 08152 - BPGM|GAPDH| Biological 19 50 12 24398 183 8 3 38 17 97|716 -3 control 09127 hate metabolic 4.6 TPI1 Processes 7 MCODE 1 biosynthetic process process RSV 19_GO:00 GO nucleotide 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 catabolic 50 12 24398 184 8 3 38 17 97|716 -3 control 09166 metabolic 4.6 TPI1 Processes process 7 MCODE 1 process positive 19_GO:00 RSV GO regulation of 51704 1072|2 infection vs GO:00 - CFL1|GAPDH| Biological 19 multi- multi- 49 12 24398 186 8 3 38 17 597|54 -3 control 43902 4.6 PPIA Processes organism organism 78 MCODE 1 process process RSV nucleoside 19_GO:00 GO 669|25 infection vs GO:00 triphosphate 08152 - BPGM|GAPDH| Biological 19 49 12 24398 188 8 3 38 17 97|716 -3 control 09142 biosynthetic metabolic 4.6 TPI1 Processes 7 MCODE 1 process process RSV 19_GO:00 GO cofactor 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 metabolic 20 8.6 24398 609 8 4 50 18 97|700 -2.9 control 51186 metabolic 4.6 PRDX2|TPI1 Processes process 1|7167 MCODE 1 process 38 RSV nucleoside 19_GO:00 GO 669|25 infection vs GO:19 phosphate 08152 - BPGM|GAPDH| Biological 19 48 12 24398 190 8 3 38 17 97|716 -2.9 control 01292 catabolic metabolic 4.6 TPI1 Processes 7 MCODE 1 process process RSV nicotinamid 19_GO:00 GO 669|25 infection vs GO:00 e nucleotide 08152 - BPGM|GAPDH| Biological 19 48 12 24398 192 8 3 38 17 97|716 -2.9 control 46496 metabolic metabolic 4.6 TPI1 Processes 7 MCODE 1 process process RSV pyridine 19_GO:00 GO 669|25 infection vs GO:00 nucleotide 08152 - BPGM|GAPDH| Biological 19 48 12 24398 192 8 3 38 17 97|716 -2.9 control 19362 metabolic metabolic 4.6 TPI1 Processes 7 MCODE 1 process process ribonucleosi RSV de 19_GO:00 GO 669|25 infection vs GO:00 monophosp 08152 - BPGM|GAPDH| Biological 19 46 12 24398 197 8 3 38 17 97|716 -2.9 control 09156 hate metabolic 4.6 TPI1 Processes 7 MCODE 1 biosynthetic process process pyridine- RSV 19_GO:00 GO containing 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 compound 46 12 24398 199 8 3 38 17 97|716 -2.9 control 72524 metabolic 4.5 TPI1 Processes metabolic 7 MCODE 1 process process RSV 19_GO:00 GO carbohydrat 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 e catabolic 46 12 24398 200 8 3 38 17 97|716 -2.9 control 16052 metabolic 4.5 TPI1 Processes process 7 MCODE 1 process nucleoside RSV 19_GO:00 GO monophosp 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 hate 44 11 24398 208 8 3 38 17 97|716 -2.9 control 09124 metabolic 4.5 TPI1 Processes biosynthetic 7 MCODE 1 process process oxidoreducti RSV 19_GO:00 GO on 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 coenzyme 43 11 24398 211 8 3 38 17 97|716 -2.8 control 06733 metabolic 4.5 TPI1 Processes metabolic 7 MCODE 1 process process RSV 19_GO:00 GO glucose 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 metabolic 43 11 24398 213 8 3 38 17 97|716 -2.8 control 06006 metabolic 4.4 TPI1 Processes process 7 MCODE 1 process regulation of symbiosis, 19_GO:00 RSV GO encompassi 51704 1072|2 infection vs GO:00 - CFL1|GAPDH| Biological 19 ng multi- 41 11 24398 225 8 3 38 17 597|54 -2.8 control 43903 4.4 PPIA Processes mutualism organism 78 MCODE 1 through process parasitism nucleobase- RSV containing 19_GO:00 GO 669|25 infection vs GO:00 small 08152 - BPGM|GAPDH| Biological 19 40 11 24398 227 8 3 38 17 97|716 -2.8 control 34404 molecule metabolic 4.4 TPI1 Processes 7 MCODE 1 biosynthetic process process RSV organophos 19_GO:00 GO 669|25 infection vs GO:00 phate 08152 - BPGM|GAPDH| Biological 19 37 10 24398 249 8 3 38 17 97|716 -2.7 control 46434 catabolic metabolic 4.2 TPI1 Processes 7 MCODE 1 process process RSV 19_GO:00 GO hexose 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 metabolic 36 10 24398 253 8 3 38 17 97|716 -2.7 control 19318 metabolic 4.2 TPI1 Processes process 7 MCODE 1 process 39 RSV 19_GO:00 GO coenzyme 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 biosynthetic 35 10 24398 260 8 3 38 17 97|716 -2.6 control 09108 metabolic 4.2 TPI1 Processes process 7 MCODE 1 process purine RSV 19_GO:00 GO ribonucleoti 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 de 33 9.7 24398 279 8 3 38 17 97|716 -2.5 control 09152 metabolic 4.1 TPI1 Processes biosynthetic 7 MCODE 1 process process RSV ribonucleoti 19_GO:00 GO 669|25 infection vs GO:00 de 08152 BPGM|GAPDH| Biological 19 -4 31 9.4 24398 292 8 3 38 17 97|716 -2.5 control 09260 biosynthetic metabolic TPI1 Processes 7 MCODE 1 process process RSV monosacch 19_GO:00 GO 669|25 infection vs GO:00 aride 08152 BPGM|GAPDH| Biological 19 -4 31 9.4 24398 295 8 3 38 17 97|716 -2.5 control 05996 metabolic metabolic TPI1 Processes 7 MCODE 1 process process RSV ribose 19_GO:00 GO 669|25 infection vs GO:00 phosphate 08152 BPGM|GAPDH| Biological 19 -4 31 9.3 24398 299 8 3 38 17 97|716 -2.5 control 46390 biosynthetic metabolic TPI1 Processes 7 MCODE 1 process process RSV purine 19_GO:00 GO 669|25 infection vs GO:00 nucleotide 08152 BPGM|GAPDH| Biological 19 -4 30 9.3 24398 300 8 3 38 17 97|716 -2.5 control 06164 biosynthetic metabolic TPI1 Processes 7 MCODE 1 process process RSV 19_GO:00 GO ATP 669|25 infection vs GO:00 08152 BPGM|GAPDH| Biological 19 metabolic -4 30 9.2 24398 306 8 3 38 17 97|716 -2.5 control 46034 metabolic TPI1 Processes process 7 MCODE 1 process purine- RSV 19_GO:00 GO containing 669|25 infection vs GO:00 08152 BPGM|GAPDH| Biological 19 compound -4 29 9.1 24398 313 8 3 38 17 97|716 -2.4 control 72522 metabolic TPI1 Processes biosynthetic 7 MCODE 1 process process RSV 19_GO:00 GO cofactor 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 biosynthetic 28 8.9 24398 324 8 3 38 17 97|716 -2.4 control 51188 metabolic 3.9 TPI1 Processes process 7 MCODE 1 process purine RSV ribonucleosi 19_GO:00 GO 669|25 infection vs GO:00 de 08152 - BPGM|GAPDH| Biological 19 27 8.8 24398 335 8 3 38 17 97|716 -2.4 control 09205 triphosphate metabolic 3.9 TPI1 Processes 7 MCODE 1 metabolic process process RSV monocarbox 19_GO:00 GO 669|25 infection vs GO:00 ylic acid 08152 - BPGM|GAPDH| Biological 19 27 8.7 24398 341 8 3 38 17 97|716 -2.4 control 72330 biosynthetic metabolic 3.8 TPI1 Processes 7 MCODE 1 process process ribonucleosi RSV 19_GO:00 GO de 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 triphosphate 27 8.7 24398 341 8 3 38 17 97|716 -2.4 control 09199 metabolic 3.8 TPI1 Processes metabolic 7 MCODE 1 process process purine ribonucleosi RSV 19_GO:00 GO de 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 monophosp 27 8.7 24398 342 8 3 38 17 97|716 -2.4 control 09167 metabolic 3.8 TPI1 Processes hate 7 MCODE 1 process metabolic process RSV 19_GO:00 GO purine 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 nucleoside 27 8.7 24398 342 8 3 38 17 97|716 -2.4 control 09144 metabolic 3.8 TPI1 Processes triphosphate 7 MCODE 1 process 40 metabolic process purine RSV nucleoside 19_GO:00 GO 669|25 infection vs GO:00 monophosp 08152 - BPGM|GAPDH| Biological 19 27 8.7 24398 343 8 3 38 17 97|716 -2.4 control 09126 hate metabolic 3.8 TPI1 Processes 7 MCODE 1 metabolic process process ribonucleosi RSV de 19_GO:00 GO 669|25 infection vs GO:00 monophosp 08152 - BPGM|GAPDH| Biological 19 26 8.5 24398 356 8 3 38 17 97|716 -2.3 control 09161 hate metabolic 3.8 TPI1 Processes 7 MCODE 1 metabolic process process RSV nucleoside 19_GO:00 GO 669|25 infection vs GO:00 triphosphate 08152 - BPGM|GAPDH| Biological 19 25 8.4 24398 362 8 3 38 17 97|716 -2.3 control 09141 metabolic metabolic 3.8 TPI1 Processes 7 MCODE 1 process process nucleoside RSV 19_GO:00 GO monophosp 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 hate 24 8.2 24398 377 8 3 38 17 97|716 -2.3 control 09123 metabolic 3.7 TPI1 Processes metabolic 7 MCODE 1 process process RSV 19_GO:00 GO nucleotide 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 biosynthetic 24 8.2 24398 385 8 3 38 17 97|716 -2.2 control 09165 metabolic 3.7 TPI1 Processes process 7 MCODE 1 process RSV nucleoside 19_GO:00 GO 669|25 infection vs GO:19 phosphate 08152 - BPGM|GAPDH| Biological 19 24 8.1 24398 389 8 3 38 17 97|716 -2.2 control 01293 biosynthetic metabolic 3.7 TPI1 Processes 7 MCODE 1 process process RSV 19_GO:00 GO coenzyme 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 metabolic 22 7.9 24398 407 8 3 38 17 97|716 -2.2 control 06732 metabolic 3.6 TPI1 Processes process 7 MCODE 1 process RSV GO Cellular infection vs GO:00 focal - 60|107 ACTB|CFL1|PP Component 20 22 7.9 24398 410 8 3 38 17 -2.2 control 05925 adhesion 3.6 2|5478 IA s MCODE 1 RSV cell- GO Cellular infection vs GO:00 substrate - 60|107 ACTB|CFL1|PP Component 20 22 7.9 24398 413 8 3 38 17 -2.2 control 05924 adherens 3.6 2|5478 IA s MCODE 1 junction RSV GO Cellular cell- infection vs GO:00 - 60|107 ACTB|CFL1|PP Component 20 substrate 22 7.8 24398 417 8 3 38 17 -2.2 control 30055 3.6 2|5478 IA s junction MCODE 1 RSV small 19_GO:00 GO 669|25 infection vs GO:00 molecule 08152 - BPGM|GAPDH| Biological 19 21 7.5 24398 445 8 3 38 17 97|716 -2.1 control 44282 catabolic metabolic 3.5 TPI1 Processes 7 MCODE 1 process process RSV carboxylic 19_GO:00 GO 669|25 infection vs GO:00 acid 08152 - BPGM|GAPDH| Biological 19 20 7.4 24398 462 8 3 38 17 97|716 -2 control 46394 biosynthetic metabolic 3.5 TPI1 Processes 7 MCODE 1 process process RSV 19_GO:00 GO organic acid 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 biosynthetic 20 7.4 24398 463 8 3 38 17 97|716 -2 control 16053 metabolic 3.5 TPI1 Processes process 7 MCODE 1 process RSV 19_GO:00 GO regulation of 2335|2 infection vs GO:00 51179 - FN1|GAPDH|P Biological 19 protein 19 7.1 24398 492 8 3 38 17 597|54 -2 control 50708 localizatio 3.4 PIA Processes secretion 78 MCODE 1 n 41 RSV 19_GO:00 GO regulation of 2335|2 infection vs GO:00 51179 - FN1|GAPDH|P Biological 19 peptide 18 6.9 24398 520 8 3 38 17 597|54 -1.9 control 02791 localizatio 3.3 PIA Processes secretion 78 MCODE 1 n RSV generation 19_GO:00 GO 669|25 infection vs GO:00 of precursor 08152 - BPGM|GAPDH| Biological 19 18 6.9 24398 522 8 3 38 17 97|716 -1.9 control 06091 metabolites metabolic 3.3 TPI1 Processes 7 MCODE 1 and energy process purine RSV 19_GO:00 GO ribonucleoti 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 de 17 6.8 24398 543 8 3 38 17 97|716 -1.9 control 09150 metabolic 3.2 TPI1 Processes metabolic 7 MCODE 1 process process RSV GO Cellular infection vs GO:00 adherens - 60|107 ACTB|CFL1|PP Component 20 17 6.7 24398 549 8 3 38 17 -1.9 control 05912 junction 3.2 2|5478 IA s MCODE 1 RSV ribonucleoti 19_GO:00 GO 669|25 infection vs GO:00 de 08152 - BPGM|GAPDH| Biological 19 16 6.7 24398 558 8 3 38 17 97|716 -1.9 control 09259 metabolic metabolic 3.2 TPI1 Processes 7 MCODE 1 process process RSV GO Cellular infection vs GO:00 anchoring - 60|107 ACTB|CFL1|PP Component 20 16 6.6 24398 565 8 3 38 17 -1.8 control 70161 junction 3.2 2|5478 IA s MCODE 1 19_GO:00 RSV GO 50896 infection vs GO:00 wound - 60|233 ACTB|FN1|PR Biological 19 response 16 6.5 24398 576 8 3 38 17 -1.8 control 42060 healing 3.2 5|7001 DX2 Processes to MCODE 1 stimulus RSV purine 19_GO:00 GO 669|25 infection vs GO:00 nucleotide 08152 - BPGM|GAPDH| Biological 19 16 6.5 24398 577 8 3 38 17 97|716 -1.8 control 06163 metabolic metabolic 3.2 TPI1 Processes 7 MCODE 1 process process RSV ribose 19_GO:00 GO 669|25 infection vs GO:00 phosphate 08152 - BPGM|GAPDH| Biological 19 16 6.5 24398 578 8 3 38 17 97|716 -1.8 control 19693 metabolic metabolic 3.2 TPI1 Processes 7 MCODE 1 process process cell morphogen 19_GO:00 RSV GO esis 32502 infection vs GO:00 - 60|107 ACTB|CFL1|FN Biological 19 involved in developm 15 6.4 24398 598 8 3 38 17 -1.8 control 48667 3.1 2|2335 1 Processes neuron ental MCODE 1 differentiatio process n purine- RSV 19_GO:00 GO containing 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 compound 15 6.3 24398 613 8 3 38 17 97|716 -1.8 control 72521 metabolic 3.1 TPI1 Processes metabolic 7 MCODE 1 process process RSV 19_GO:00 GO 2335|2 infection vs GO:00 protein 51179 - FN1|GAPDH|P Biological 19 15 6.3 24398 614 8 3 38 17 597|54 -1.8 control 09306 secretion localizatio 3.1 PIA Processes 78 MCODE 1 n RSV 19_GO:00 GO carbohydrat 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 e metabolic 15 6.2 24398 629 8 3 38 17 97|716 -1.7 control 05975 metabolic 3.1 TPI1 Processes process 7 MCODE 1 process RSV 19_GO:00 GO 2335|2 infection vs GO:00 peptide 51179 FN1|GAPDH|P Biological 19 -3 14 6.1 24398 649 8 3 38 17 597|54 -1.7 control 02790 secretion localizatio PIA Processes 78 MCODE 1 n 42 RSV monocarbox 19_GO:00 GO 669|25 infection vs GO:00 ylic acid 08152 BPGM|GAPDH| Biological 19 -3 14 6.1 24398 651 8 3 38 17 97|716 -1.7 control 32787 metabolic metabolic TPI1 Processes 7 MCODE 1 process process 19_GO:00 RSV neuron GO 32502 infection vs GO:00 projection 60|107 ACTB|CFL1|FN Biological 19 developm -3 14 6.1 24398 658 8 3 38 17 -1.7 control 48812 morphogen 2|2335 1 Processes ental MCODE 1 esis process nucleobase- RSV 19_GO:00 GO containing 669|25 infection vs GO:00 08152 BPGM|GAPDH| Biological 19 compound -3 14 6 24398 664 8 3 38 17 97|716 -1.7 control 34655 metabolic TPI1 Processes catabolic 7 MCODE 1 process process plasma membrane 19_GO:00 RSV GO bounded 32502 infection vs GO:01 60|107 ACTB|CFL1|FN Biological 19 cell developm -3 14 6 24398 672 8 3 38 17 -1.7 control 20039 2|2335 1 Processes projection ental MCODE 1 morphogen process esis 19_GO:00 RSV cell GO 32502 infection vs GO:00 projection 60|107 ACTB|CFL1|FN Biological 19 developm -3 14 6 24398 676 8 3 38 17 -1.7 control 48858 morphogen 2|2335 1 Processes ental MCODE 1 esis process 19_GO:00 RSV GO 50896 infection vs GO:00 response to - 60|233 ACTB|FN1|PR Biological 19 response 13 5.9 24398 691 8 3 38 17 -1.6 control 09611 wounding 2.9 5|7001 DX2 Processes to MCODE 1 stimulus 19_GO:00 RSV GO cell part 32502 infection vs GO:00 - 60|107 ACTB|CFL1|FN Biological 19 morphogen developm 13 5.9 24398 696 8 3 38 17 -1.6 control 32990 2.9 2|2335 1 Processes esis ental MCODE 1 process RSV organophos 19_GO:00 GO 669|25 infection vs GO:00 phate 08152 - BPGM|GAPDH| Biological 19 13 5.9 24398 700 8 3 38 17 97|716 -1.6 control 90407 biosynthetic metabolic 2.9 TPI1 Processes 7 MCODE 1 process process RSV 19_GO:00 GO nucleotide 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 metabolic 13 5.8 24398 710 8 3 38 17 97|716 -1.6 control 09117 metabolic 2.9 TPI1 Processes process 7 MCODE 1 process RSV nucleoside 19_GO:00 GO 669|25 infection vs GO:00 phosphate 08152 - BPGM|GAPDH| Biological 19 13 5.8 24398 717 8 3 38 17 97|716 -1.6 control 06753 metabolic metabolic 2.9 TPI1 Processes 7 MCODE 1 process process RSV 19_GO:00 GO heterocycle 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 catabolic 13 5.8 24398 717 8 3 38 17 97|716 -1.6 control 46700 metabolic 2.9 TPI1 Processes process 7 MCODE 1 process cellular RSV 19_GO:00 GO nitrogen 669|25 infection vs GO:00 08152 - BPGM|GAPDH| Biological 19 compound 13 5.8 24398 718 8 3 38 17 97|716 -1.6 control 44270 metabolic 2.9 TPI1 Processes catabolic 7 MCODE 1 process process RSV 19_GO:00 GO regulation of 2335|2 infection vs GO:00 51179 - FN1|GAPDH|P Biological 19 protein 13 5.8 24398 725 8 3 38 17 597|54 -1.6 control 51223 localizatio 2.9 PIA Processes transport 78 MCODE 1 n GO 669|25 RSV GO:00 aromatic 19_GO:00 - BPGM|GAPDH| Biological 19 13 5.7 24398 730 8 3 38 17 97|716 -1.6 infection vs 19439 compound 08152 2.9 TPI1 Processes 7 43 control catabolic metabolic MCODE 1 process process RSV 19_GO:00 GO regulation of 2335|2 infection vs GO:00 51179 - FN1|GAPDH|P Biological 19 peptide 12 5.6 24398 755 8 3 38 17 597|54 -1.6 control 90087 localizatio 2.8 PIA Processes transport 78 MCODE 1 n cell 19_GO:00 RSV morphogen GO 32502 infection vs GO:00 esis - 60|107 ACTB|CFL1|FN Biological 19 developm 12 5.6 24398 756 8 3 38 17 -1.6 control 00904 involved in 2.8 2|2335 1 Processes ental MCODE 1 differentiatio process n organic RSV 19_GO:00 GO cyclic 669|25 infection vs GO:19 08152 - BPGM|GAPDH| Biological 19 compound 12 5.6 24398 768 8 3 38 17 97|716 -1.5 control 01361 metabolic 2.8 TPI1 Processes catabolic 7 MCODE 1 process process RSV regulation of 19_GO:00 GO 2335|2 infection vs GO:00 establishme 51179 - FN1|GAPDH|P Biological 19 12 5.5 24398 772 8 3 38 17 597|54 -1.5 control 70201 nt of protein localizatio 2.8 PIA Processes 78 MCODE 1 localization n RSV carbohydrat 19_GO:00 GO 669|25 infection vs GO:19 e derivative 08152 - BPGM|GAPDH| Biological 19 12 5.5 24398 774 8 3 38 17 97|716 -1.5 control 01137 biosynthetic metabolic 2.8 TPI1 Processes 7 MCODE 1 process process RSV 19_GO:00 GO regulation of 2335|2 infection vs GO:19 51179 - FN1|GAPDH|P Biological 19 secretion by 12 5.5 24398 777 8 3 38 17 597|54 -1.5 control 03530 localizatio 2.8 PIA Processes cell 78 MCODE 1 n RSV cytokine- GO 19_GO:00 1072|2 infection vs GO:00 mediated - CFL1|FN1|PPI Biological 19 23052 11 5.5 24398 796 8 3 38 17 335|54 -1.5 control 19221 signaling 2.8 A Processes signaling 78 MCODE 1 pathway RSV GO Cellular membrane infection vs GO:00 2.60E+0 727|73 Component 20 attack -10 89 24398 7 4 3 75 22 C5|C7|C9 -7.5 control 05579 3 0|735 s complex MCODE 2 19_GO:00 RSV GO regulation of 02376 727|73 infection vs GO:00 - 2.10E+0 1.00 Biological 19 complement immune 29 24398 116 4 4 22 0|735|7 C5|C7|C9|VTN -6.6 control 30449 9.3 2 E+02 Processes activation system 448 MCODE 2 process 19_GO:00 RSV regulation of GO 50896 727|73 infection vs GO:20 protein - 2.10E+0 1.00 Biological 19 response 29 24398 117 4 4 22 0|735|7 C5|C7|C9|VTN -6.6 control 00257 activation 9.3 2 E+02 Processes to 448 MCODE 2 cascade stimulus 19_GO:00 RSV regulation of GO 02376 727|73 infection vs GO:00 humoral 1.80E+0 1.00 Biological 19 immune -9 27 24398 135 4 4 22 0|735|7 C5|C7|C9|VTN -6.4 control 02920 immune 2 E+02 Processes system 448 MCODE 2 response process 19_GO:00 RSV complement GO 02376 infection vs GO:00 activation, 1.10E+0 727|73 Biological 19 immune -9 59 24398 16 4 3 75 22 C5|C7|C9 -6.4 control 06957 alternative 3 0|735 Processes system MCODE 2 pathway process 19_GO:00 RSV regulation of GO 50896 727|73 infection vs GO:00 acute - 1.50E+0 1.00 Biological 19 response 25 24398 161 4 4 22 0|735|7 C5|C7|C9|VTN -6.2 control 02673 inflammator 8.7 2 E+02 Processes to 448 MCODE 2 y response stimulus 44 19_GO:00 RSV GO 02376 727|73 infection vs GO:00 complement - 1.40E+0 1.00 Biological 19 immune 23 24398 178 4 4 22 0|735|7 C5|C7|C9|VTN -6.1 control 06956 activation 8.6 2 E+02 Processes system 448 MCODE 2 process RSV 19_GO:00 GO regulation of 727|73 infection vs GO:00 08152 - 1.40E+0 1.00 Biological 19 protein 23 24398 180 4 4 22 0|735|7 C5|C7|C9|VTN -6 control 70613 metabolic 8.5 2 E+02 Processes processing 448 MCODE 2 process RSV GO Cellular infection vs GO:00 pore - 8.00E+0 727|73 Component 20 49 24398 23 4 3 75 22 C5|C7|C9 -6 control 46930 complex 8.5 2 0|735 s MCODE 2 RSV 19_GO:00 GO regulation of 727|73 infection vs GO:19 08152 - 1.30E+0 1.00 Biological 19 protein 23 24398 182 4 4 22 0|735|7 C5|C7|C9|VTN -6 control 03317 metabolic 8.5 2 E+02 Processes maturation 448 MCODE 2 process 19_GO:00 RSV GO protein 50896 727|73 infection vs GO:00 - 1.20E+0 1.00 Biological 19 activation response 22 24398 201 4 4 22 0|735|7 C5|C7|C9|VTN -5.9 control 72376 8.3 2 E+02 Processes cascade to 448 MCODE 2 stimulus RSV 19_GO:00 GO infection vs GO:00 09987 - 6.50E+0 727|73 Biological 19 cytolysis 44 24398 28 4 3 75 22 C5|C7|C9 -5.8 control 19835 cellular 8.3 2 0|735 Processes MCODE 2 process 19_GO:00 RSV GO acute 50896 727|73 infection vs GO:00 - 1.10E+0 1.00 Biological 19 inflammator response 21 24398 222 4 4 22 0|735|7 C5|C7|C9|VTN -5.8 control 02526 8.2 2 E+02 Processes y response to 448 MCODE 2 stimulus RSV 19_GO:00 GO 727|73 infection vs GO:00 protein 08152 - 1.00 Biological 19 75 17 24398 327 4 4 22 0|735|7 C5|C7|C9|VTN -5.2 control 16485 processing metabolic 7.5 E+02 Processes 448 MCODE 2 process 19_GO:00 RSV GO humoral 02376 727|73 infection vs GO:00 - 1.00 Biological 19 immune immune 68 16 24398 361 4 4 22 0|735|7 C5|C7|C9|VTN -5 control 06959 7.3 E+02 Processes response system 448 MCODE 2 process RSV 19_GO:00 GO 727|73 infection vs GO:00 protein 08152 - 1.00 Biological 19 62 16 24398 396 4 4 22 0|735|7 C5|C7|C9|VTN -4.9 control 51604 maturation metabolic 7.2 E+02 Processes 448 MCODE 2 process 19_GO:00 RSV regulation of GO 02376 727|73 infection vs GO:00 immune - 1.00 Biological 19 immune 52 14 24398 466 4 4 22 0|735|7 C5|C7|C9|VTN -4.7 control 02697 effector 6.9 E+02 Processes system 448 MCODE 2 process process 19_GO:00 RSV GO regulation of 50896 727|73 infection vs GO:00 - 1.00 Biological 19 inflammator response 48 14 24398 508 4 4 22 0|735|7 C5|C7|C9|VTN -4.6 control 50727 6.7 E+02 Processes y response to 448 MCODE 2 stimulus RSV plasma GO Cellular 727|73 infection vs GO:00 membrane - 1.00 Component 20 35 12 24398 691 4 4 22 0|735|7 C5|C7|C9|VTN -4.2 control 98797 protein 6.2 E+02 s 448 MCODE 2 complex 19_GO:00 RSV complement GO 02376 infection vs GO:00 activation, - 1.30E+0 727|73 Biological 19 immune 20 24398 141 4 3 75 22 C5|C7|C9 -4.1 control 06958 classical 6.1 2 0|735 Processes system MCODE 2 pathway process 45 19_GO:00 RSV GO activation of 02376 727|73 infection vs GO:00 - 1.00 Biological 19 immune immune 33 11 24398 731 4 4 22 0|735|7 C5|C7|C9|VTN -4.1 control 02253 6.1 E+02 Processes response system 448 MCODE 2 process humoral immune 19_GO:00 RSV GO response 02376 infection vs GO:00 1.20E+0 727|73 Biological 19 mediated by immune -6 19 24398 154 4 3 75 22 C5|C7|C9 -4 control 02455 2 0|735 Processes circulating system MCODE 2 immunoglob process ulin immunoglob 19_GO:00 RSV GO ulin 02376 infection vs GO:00 - 727|73 Biological 19 mediated immune 81 16 24398 225 4 3 75 22 C5|C7|C9 -3.6 control 16064 5.5 0|735 Processes immune system MCODE 2 response process 19_GO:00 RSV GO B cell 02376 infection vs GO:00 - 727|73 Biological 19 mediated immune 80 15 24398 228 4 3 75 22 C5|C7|C9 -3.6 control 19724 5.5 0|735 Processes immunity system MCODE 2 process 19_GO:00 RSV GO lymphocyte 02376 infection vs GO:00 - 727|73 Biological 19 mediated immune 50 12 24398 364 4 3 75 22 C5|C7|C9 -3.1 control 02449 4.9 0|735 Processes immunity system MCODE 2 process adaptive immune response based on 19_GO:00 RSV somatic GO 02376 infection vs GO:00 recombinati - 727|73 Biological 19 immune 50 12 24398 366 4 3 75 22 C5|C7|C9 -3.1 control 02460 on of 4.9 0|735 Processes system MCODE 2 immune process receptors built from immunoglob uli 19_GO:00 RSV GO adaptive 02376 infection vs GO:00 727|73 Biological 19 immune immune -4 26 8.7 24398 696 4 3 75 22 C5|C7|C9 -2.5 control 02250 0|735 Processes response system MCODE 2 process RSV GO actin 2316|7 infection vs GO:00 - 1.20E+0 1.00 FLNA|TLN1|TP Molecular 21 filament 19 24398 200 3 3 27 094|71 -4.2 control 51015 6.3 2 E+02 M2 Functions binding 69 MCODE 3 19_GO:00 RSV 32501 GO 2316|7 infection vs GO:00 muscle multicellul - 1.00 FLNA|TLN1|TP Biological 19 68 14 24398 359 3 3 27 094|71 -3.6 control 06936 contraction ar 5.5 E+02 M2 Processes 69 MCODE 3 organisma l process RSV GO 2316|7 infection vs GO:00 actin - 1.00 FLNA|TLN1|TP Molecular 21 57 13 24398 431 3 3 27 094|71 -3.4 control 03779 binding 5.3 E+02 M2 Functions 69 MCODE 3 19_GO:00 RSV 32501 GO muscle 2316|7 infection vs GO:00 multicellul - 1.00 FLNA|TLN1|TP Biological 19 system 53 12 24398 462 3 3 27 094|71 -3.4 control 03012 ar 5.2 E+02 M2 Processes process 69 MCODE 3 organisma l process 46 19_GO:00 71840 cellular RSV actin GO componen 2316|7 infection vs GO:00 cytoskeleto - 1.00 FLNA|TLN1|TP Biological 19 t 35 10 24398 692 3 3 27 094|71 -3 control 30036 n 4.6 E+02 M2 Processes organizati 69 MCODE 3 organization on or biogenesi s RSV actin 19_GO:00 GO 2316|7 infection vs GO:00 filament- 09987 - 1.00 FLNA|TLN1|TP Biological 19 31 9.5 24398 785 3 3 27 094|71 -2.9 control 30029 based cellular 4.5 E+02 M2 Processes 69 MCODE 3 process process