US 20070275021A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2007/0275021 A1 Lee et al. (43) Pub. Date: Nov. 29, 2007

(54) NEW COSMETIC, PERSONAL CARE, Continuation-in-part of application No. 09/456,196, CLEANING AGENT, AND NUTRITIONAL filed on Dec. 7, 1999, now abandoned. SUPPLEMENT COMPOSITIONS AND Continuation-in-part of application No. 09/456,195, METHODS OF MAKING AND USING SAME filed on Dec. 7, 1999, now abandoned. (75) Inventors: Sean Lee, Karlsruhe (DE); Susanna (60) Provisional application No. 60/192.216, filed on Mar. Kessler, Ergolding (DE); Oliver 27, 2000. Provisional application No. 60/197,162, Forberich, Oberursel (DE); Claire filed on Apr. 14, 2000. Buchwar, Wiesbaden (DE); David C. Greenspan, Gainesville, FL (US) Publication Classification Correspondence Address: (51) Int. Cl. KRAMER LEVN NAFTALIS & FRANKEL A6IR 33/00 (2006.01) LLP A6IR 8/25 (2006.01) INTELLECTUAL PROPERTY DEPARTMENT A61O 1704 (2006.01) 1177 AVENUE OF THE AMERICAS (52) U.S. Cl...... 424/401; 424/59: 424/65; NEW YORK, NY 10036 (US) 424/70.1; 424/724; 510/511 (73) Assignee: SCHOTT AG, MAINZ (DE) (57) ABSTRACT The present invention involves new cosmetic, personal care, (21) Appl. No.: 11/775,615 cleaning agent, biocidal agent, functional food, and nutri tional Supplement compositions. These new compositions (22) Filed: Jul. 10, 2007 incorporate bioactive glass into cosmetics, personal care Related U.S. Application Data items, cleaning agents, biocidal agents, functional foods, and nutritional Supplements. The present invention also involves (60) Division of application No. 09/818,466, filed on Mar. methods of making and methods of using such composi 27, 2001, now Pat. No. 7,250,174. tions. US 2007/0275021 A1 Nov. 29, 2007

NEW COSMETIC, PERSONAL CARE, CLEANING As used herein “bioactive glass” is an inorganic glass AGENT, AND NUTRITIONAL SUPPLEMENT material having an oxide of silicon as its major component. COMPOSITIONS AND METHODS OF MAKING The use of bioactive glass for unrelated purposes such as AND USING SAME orthopedic repair is described by Larry L. Hench and Jon K. West in “Biological Applications of Bioactive Glasses' Life RELATED APPLICATIONS Chemistry Reports, 1996, Vol. 13, pp. 187-241, the contents 0001. This application claims priority from co-pending of which are incorporated herein by reference. U.S. Provisional Application No. 60/192.261, filed Mar. 27, 2000, co-pending U.S. Provisional Application No. 60/197, DETAILED DESCRIPTION OF THE 162, filed Apr. 14, 2000, co-pending U.S. application Ser. INVENTION No. 09/456,196, filed Dec. 7, 1999, and co-pending U.S. application Ser. No. 09/456,195, filed Dec. 7, 1999. The full 0007 Bioactive glass is a sodium-calcium-phospho-sili disclosure of each of these applications is incorporated cate glass. As used herein, the term “bioactive glass' may herein by reference. refer to particulate melt-derived and/or sol-gel derived bio active glass. In addition, the term “bioactive glass may be FIELD OF THE INVENTION used to refer to an aqueous extract of particulate melt 0002 The present invention involves new cosmetic, per derived an/or sol-gel derived bioactive glass. Sonal care, cleaning agent, biocidal agent, functional food, 0008. The present invention utilizes bioactive glass pref and nutritional Supplement compositions. These new com erably between 40 and 96% by weight of silicon dioxide positions incorporate bioactive glass into cosmetics, clean oxide (SiO), between about 0 and 35% by weight of sodium ing agents, personal care products, biocidal agents, func oxide (NaO), between about 4 and 46% by weight calcium tional foods and nutritional Supplements. The present oxide (CaO), and between about 1 and 15% by weight invention also involves methods of making and methods of phosphorus oxide (POs). As referred herein, bioactive using Such compositions. glasses are typically silicon dioxide based compositions capable of forming hydroxycarbonate apatite (HCA). More BACKGROUND OF THE INVENTION preferably, the glass includes between 40 and 60% by weight 0003 Preservatives are necessary and important ingredi of silicon dioxide oxide (SiO2), between about 5-30% by ents that ensure the stability and safety of different products. weight of sodium oxide (NaO), between about 10 and 35% Many problems exist with respect to known preservatives. by weight calcium oxide (CaO), and between about 1 and Many have unwanted effects on the products they are in or 12% by weight phosphorus oxide (POs). The oxides can be on the person or thing for which the products are used. Many present as Solid solutions or mixed oxides, or as mixtures of are relatively expensive and have no beneficial effects oxides. besides preservation. Many, in fact, are not efficacious as preservatives. Many have effects on the products texture or 0009 CaF, B.O.s, Al2O, MgO and KO may be taste that make them undesirable. Better preservatives are included in the composition in addition to silicon, Sodium, needed. phosphorus and calcium oxides. The preferred range for BO, is between 0 and 10% by weight. The preferred range 0004 There has also been a great need for ingredients for KO is between 0 and 8% by weight. The preferred range that can be used safely and beneficially in products that have for MgO is between 0 and 5% by weight. antibacterial, antifungal, antiviral, ion releasing, anti-inflam matory and/or pH properties in the products themselves 0010 Typically, bioactive glasses have the following and/or on the person or thing for which the product issued. composition by weight percentage: Ingredients that can express one or more of these properties are needed.

SUMMARY OF THE INVENTION Component Wt. Percent SiO, 40-90 0005. Applicants have found that bioactive glass when CaO 4-45 used in a wide variety of cosmetics provides exceptional Na2O O-3S qualities to the cosmetic including a beneficial preservative POs 2-16 effect. Applicants also have found that bioactive glass pre CaF, O-2S serves a variety of standard household and industrial clean B2O3 O-4 ing agents. Further, certain bioactive glass compositions KO O-8 provide excellent cleaning properties and greatly enhance MgO O-5 the cleaning properties of standard household and industrial cleaning agents. In addition, applicants have found that certain bioactive glass compositions are useful as a func 0011. A more preferred composition by weight percent tional food and nutritional Supplement or used in such. age for bioactive glass is as follows: Moreover, certain bioactive glass compositions act as an excellent preservative for food. 0006. In addition, the compositions of this invention can Component Wt. Percent be formulated as disclosed herein to have enhanced and SiO2 40-68 beneficial properties that include antibacterial, antiviral, CaO S-30 antifungal, ion-releasing, anti-inflammatory and pH effects. US 2007/0275021 A1 Nov. 29, 2007

environment. While not being bound by a specific mecha -continued nism of action, it is believed that this action is a result, inter alia, of the greatly increased bioactivity of the Small par Component Wt. Percent ticulates, which leads to an increased pH of the Surrounding Na2O 1O-35 environment. The combined properties of being both POs 1-12 broadly bactericidal while at the same time maintaining tissue biocompatibility make a variety of formulations com prising Small particles of bioactive glass resistant to micro 0012. The present invention includes formulations which bial contamination and especially Suitable for formulations may comprise metal ions such as AgNO, CuO, and ZnO, or which will contact the skin. other antimicrobial salts, including but not limited to, silver, 0018. The antimicrobial action increases with decreasing copper and Zinc ions. These metals may be in nitrate or particle size. The preferred particle size depends, in part, on acetate form. The preferred range for these salts is between the expected microbial challenge and the desired purity of 0 and 15% by weight. The present invention also includes the formulation comprising bioactive glass For example, formulations which do not comprise metal ions. formulations having bioactive glass particles averaging 20 0013 The most preferred glass is Bioglass(R (a trademark microns ordinarily is sufficient. However, for a longer last of University of Florida), which has a composition including ing preservative effect or to maintain a higher degree of about 45% by weight silicon dioxide, about 24.5% by purity, particles averaging less than five microns as mea weight sodium oxide, about 6% by weight phosphorus sured by SEM or laser light scattering techniques may be oxide, and about 24.5% by weight calcium oxide. Another used. When highly porous bioactive glass is used in place of preferred material is hydroxyapatite. Another preferred or in addition to Small particles of bioactive glass, the pore material for several applications are the porous Sol-gel size is between about 0 and 500 um, preferably between glasses. about 10 and 150 lum, and more preferably, between about 50 and 100 Lum. The degree of porosity of the glass is 0014 Particulate, non-interlinked bioactive glass is pre between about 0 and 85%, preferably between about 30 and ferred for many embodiments of the present invention. That 80%, and more preferably between about 40 and 60%. is, the glass is in the form of Small, discrete particles, rather Porous bioactive glass can be prepared, for example, by than a fused matrix of particles or a mesh or fabric (woven incorporating a leachable Substance into the bioactive glass or non-woven) of glass fibers. Note that under some condi composition, and leaching the Substance out of the glass. tions the discrete particles of the present invention may tend Suitable leachable substances are well known to those of to cling together because of electrostatic or other forces but skill in the art, and include, for example, Sodium chloride are still considered to be non-interlinked. Preferably the and other water-soluble salts. The particle size of the leach particle size is less than about 90 microns; more preferably, able substance is roughly the size of the resulting pore. The less than about 20 microns; even more preferably, less than relative amount and size of the leachable Substance gives about 5 microns, and most preferably, less than about 2 rise to the degree of porosity. Also, as described herein, microns, as measured by SEM or laser light scattering porosity can be achieved using sintering and/or by control techniques, although different uses may advantageously use ling the treatment cycle of glass gels to control the pores and different particle sizes. interpores of the material. 0.015 The preferred particle size range for the bioactive 0019. In addition, anti-microbial and anti-inflammatory glass is site and use dependent. Particle sizes less than about compositions derived from aqueous extracts of bioactive 1000 microns and greater than about 2 microns can also be glass can be formed by placing bioactive glass in an aqueous used. Particles of Such a small size range generally provide Solution, allowing the glass to dissolve over a suitable period for the advantages of the present invention without eliciting of time, for example, a week or more, and filtering out the undesirable immune responses. dissolved glass particles. The solvent can also be evaporated 0016. Without being bound to a particular theory, it is to provide a solid material with anti-microbial properties. believed that there is a complex relationship between the These compositions can be used in situations where elimi type of ion being released from the glass, the amount of that nation, reduction, or prevention of microbes, including but ion, the rate at which release occurs, the pH of the surround not limited to bacteria, viruses, and fungi would be advan ing environment, and the resulting anti-microbial or anti tageous, for example, in cosmetic formulations, cleaning inflammatory response. This effect is observed with respect agent formulations, functional foods and as a preservative to the particles of bioactive glass themselves and also in the for foods. aqueous Solutions derived from the glass particles. Accord 0020. The glass composition can be prepared in several ingly, in the compositions and uses described below, par ways to provide melt-derived glass, Sol-gel derived glass ticulate and/or bioactive glass solutions derived from the and sintered glass particles. The sintered particles may be in particles may be used. sol-gel derived, unreacted, or pre-reacted melt-derived form. 0017 Large particles of bioactive glass do not have The glass composition is preferably melt-derived. Melt appreciable antimicrobial properties. However, Small par derived glass is generally prepared by mixing grains of ticles of bioactive glass and highly porous bioactive glass do oxides or carbonates, melting and homogenizing the mix have appreciable antimicrobial properties. Bioactive glass tures at high temperatures, typically between about 1250 and has bactericidal properties and is effective against, for 1400° C. The molten glass can be flitted and milled to example, Staph. aureus, Staph. epidermidis, and various produce a small particulate material. streptococci. These bacteria may be found in and on the skin. 0021. In each preparation, it is preferred to use reagent These antimicrobial properties are enhanced in an aqueous grade glass, especially when the glass is used to prepare US 2007/0275021 A1 Nov. 29, 2007 materials which ultimately may be administered topically. derived glass is generally prepared by synthesizing an Bioactive glass particles may be prepared using the melt inorganic network by mixing metal alkoxides in solution, derived and grinding process described previously in U.S. followed by hydrolysis, gelation, and low temperature Pat. No. 5,204,106, the disclosure of which is incorporated (around 200-900° C.) firing to produce a glass. Sol-gel herein by reference. Where particular particle size ranges are derived glasses produced this way are known to have an desired, sifting may be used to obtain such particles. For initial high specific surface area (SSA) compared with either optimum sterility, glass particles may be ultrasonically melt-derived glass or porous melt derived glass. The result cleaned, packaged in Syringes and sterilized with gamma ing material contains nanometer-sized purosity and has a radiation. SSA ranging from 50-400 m/g. The sol-gel derived glass 0022. The particulate biologically active material used in does not contain Sodium. Thus, when this material comes the present invention may be prepared according to the into contact with an aqueous solution, the dissolution methods of the art such as taught in U.S. Pat. Nos. 4,159, mechanisms are different from those associated with non 358; 4,234,972; 4,103,002; 4,189,325; 134,171,544; 4,775, sol-gel-derived bioactive glass. 646; 4,857.046 and 5,074,916. For example, the raw mate 0026. Typically, sol-gel-derived bioactive glasses have rials (e.g., SiO, CaO, Na-O and POs) are mixed in a the following composition by weight percentage: Nalgene(R) plastic container on a ball mill for four hours. The mix is then melted in a platinum crucible at 1350° C. and homogenized for 24 hours. The molten glass is poured into distilled, deionized water to produce a glass frit. Alterna Component Wt. Percent tively, ribbons may be prepared by pouring the glass over SiO2 49-90 moving rollers. The frit or ribbons may be ground, for CaO 5-42 example, by one of several means. In one method the frit or POs 1-12 ribbons are ground in a mortar and pestle and passed through ASTM sieves to produce the required particle size range. Alternatively, the frit or ribbons may be ground using a 0027. A more preferred composition for sol-gel-derived ball-milling or jet milling process. bioactive glasses comprises the following composition by 0023 Bioactive glass may be derived using a drying step, weight percentage: which may include near-equilibrium drying. Near-equilib rium drying in place of or in addition to drying under dry conditions provides for much larger average pore size in the final composition at a given level of SiO2. In addition Component Wt. Percent near-equilibrium drying results in a higher rate of resorption SiO, 49-72 as compared to traditionally prepared sol-gel bioactive glass CaO 5-35 materials. For example, in-vivo testing of one has shown POs S-9 that more than 50% of sol-gel material made in this manner resorbed at eight weeks. Comparable prior 4555 melt 0028. The sol-gel-derived bioactive glass readily reacts derived bioactive glasses, do not resorb at all by eight weeks. with aqueous solutions because of the high SSA (i.e., there Indeed, it has been suggested that glasses including more is a tremendous amount of Surface area where glass/solution than 55% silicon dioxide are not bioactive. reactions can take place). When immersed in an aqueous 0024. As used herein, near-equilibrium drying is drying Solution, the sol-gel-derived bioactive glass begins to react, under the conditions near the two phase boundaries in the releasing soluble silica, calcium and phosphate anions. Once phase diagram at a temperature and pressure Sufficient to the concentration of calcium and phosphate anions is yield a bioactive glass with large pore structure, i.e., a pore increased to the saturation limit for HAp, a mineralogical, structure Sufficient to yield a bioactive glass. For example, HAp-rich layer will form on the surfaces that comprise the near-equilibrium drying may be drying under the conditions sol-gel-derived bioactive glass, and Surrounding Surfaces near the line for water as illustrated in conventional phase (i.e., hard and soft human tissues). diagrams (or other liquids such as methanol, ethanol, acetone, liquid (CO, benzene and so on). By manipulating 0029. For example, a reaction mixture including tetra the sealing of the designed drying chamber to adjust the ethoxysilane (TEOS), triethylphosphate (TEP), and calcium extent of the drying condition away from the equilibrium nitrate can be used to make sol-gel bioactive glasses. Alkox line and relative humidity (from environmental humidity to ides of calcium, titanium, Zirconium, magnesium, alumi 98%), the duration of near-equilibrium drying, and the num, iron and potassium also can be used. Other appropriate temperature at which the drying is conducted, one can ingredients will also be apparent to those of ordinary skill in drastically alter pore size of resultant bioactive glass. For the art. In addition, aerogels may be used. When an aerogel example, increasing the sealing of the drying chamber is used, increased pressure is used instead of near-equilib during drying typically results in an increase in relative rium drying to achieve larger pore size and greater resorb humidity and pore diameter. Near-equilibrium drying tem ability. perature can also be varied, for example, with water drying. 0030 Sol-gel processing which uses a near-equilibrium When using liquids other than water, such as those referred drying step yields larger pore size in the final product and to above, one may obtain a faster drying or increase the pore permits development of HCA very rapidly for both high and size range of the gel to a large extent. low silicon dioxide content gels. Indeed, these compositions 0025. A sol-gel process is any process that includes the form HCA more rapidly than other gels when exposed to use of a sol-gel in the preparation of bioactive glass. Sol-gel SBF (Simulated Body Fluid, Kokubo, T. et al., J. Biomed. US 2007/0275021 A1 Nov. 29, 2007

Mater. Res., 24, 721-34, 1990) or physiological fluids. The Cosmetics near equilibrium drying technique also provides for more General homogeneous gels which can be heated to higher tempera tures while retaining large pore diameter. This permits much 0036) The present invention provides novel cosmetics better control of the final product e.g. resorbability, homo compositions comprising bioactive glass. While current geneity and physical structure. For example, Sol-gel com manufacturing processes generally control microbial con positions derived without using near-equilibrium drying tamination when the products are in sealed containers, after techniques are not able to provide adequate resorbability at unsealing the package, bacteria, fungi and/or mold may contaminate the cosmetics. Often, various antibacterial higher levels of silicon dioxide. In contrast, the near-equi agents are added to the cosmetics to minimize this process. librium drying technique provides gels having excellent These antibacterial agents, however, often create negative resorbability even when high amounts of silicon dioxide are effects Such as skin irritation for the cosmetic user. included. Such sol-gel glasses are also more homogeneous than other sol-gel glasses and calcium is distributed uni 0037. A goal of the present invention is to produce formly. cosmetic formulations which, in contrast to presently avail able cosmetics, exhibit an ability to withstand microbial 0031. This drying technique can be used to prepare all contamination without creating negative effects such as skin types of Sol-gel bioactive glasses. For example, the tech irritation. nique can be used to prepare frit, ribbons, monoliths, pow 0038. In one embodiment of the present invention, bio ders, coatings, fibers, mats, weaves and composites. active glass may be included in cosmetic formulations to 0032 Frit can be ground to very broad ranges of particle minimize microbial contamination, including contamination size Such as from about 2 Lum up to 1 mm for any purpose. by bacteria, fungi and/or mold. The cosmetic compositions The monolith can be formed to complex shapes such as can include the aqueous extracts of bioactive glass and/or various implants. Powders can be made to spherical form particles of bioactive glass. and from Submicron to a few hundred microns. Such com 0039. In one embodiment the cosmetic formulation com positions are useful, for example, in bone repair and other prises particulate bioactive glass having an average particle orthopedic applications, drug delivery, treating tooth hyper size less than 10 microns. In another embodiment particulate sensitivity as well as the remineralization of tooth structure, bioactive glass having an average particle size less than 5 burn healing and wound healing. microns, and preferably less than 2 microns is used. Pre ferred cosmetic preparations are especially creams, make-up 0033 While not being bound to any particular theory, it compounds, lipsticks, lotions and salves since the micro is believed that the near-equilibrium drying step reduces biocidal effect of bioactive glass is further enhanced by the capillary force inside the pore structure of the gel which moisture contained in these preparations. However, bioac results in large pore size. Gels are networks of Small colloid tive glass can be added to virtually any cosmetic presently particles. The networks includes voids which become pores available to improve its resistance to contamination. Accord and pore channels in the final glass composition. It is ingly, the cosmetic may be liquid based, or alternatively, believed that the moisture of the near-equilibrium drying other than liquid based. Cosmetic formulations may include, step enhances the reaction at the neck between two particles for example, creams, lotions, lipsticks, make-up compounds in the network and the strength of the neck and “backbone' and tinctures. of the gel structure which reduces shrinkage of the drying 0040. In one embodiment the invention provides bioac structure and ultimately results in gels with large pores. tive glass for use as a preservative of perishable goods. The perishable goods may be, for example, cosmetic and/or 0034. On the other hand, due to the liquid tension, the pharmaceutical preparations. In another embodiment the pressure difference between the different size of pores and present invention provides a preservative which itself con channels is: tains bioactive glass. The preservative which contains bio active glass may be added to or included in cosmetic formulations. where, Y is liquid tension, 0 is contact angle and r is the radius of pores and pore channels. During drying, the 0041. A cosmetic formulation in accordance with the pressure difference, AP, will pull the network tight enabling present invention may contain an amount of bioactive glass pore collapse and gel shrinkage as liquid evaporates. It is up to 95% of the total weight of the cosmetic formulation, believed that near-equilibrium drying allows the liquid especially up to 70%, more especially up to 50%, or 40%, and even more preferably up to 30% of the weight of the inside the pore structure to evaporate under the condition of cosmetic formulation. Upper limits of 7% of the weight or near equilibrium at a range of temperatures. This keeps 5% of the weight are preferred for some formulations, liquid vapor pressure inside the channels and pores at high whereby 3% of the weight is especially preferred in some heating conditions which resists the shrinkage and collapse formulations. Lower limits are 0.01% of the weight, espe of the gel structure and results in large pore sizes. cially 0.1% of the weight, whereby 0.5% of the weight and 0035 Bioactive glass, sol-gel derived bioactive glass 1% of the weight are especially preferred as the lowest and/or aqueous extracts of bioactive glass may be incorpo effective amounts. rated into various cosmetic, cleaning agent, functional 0042. In one embodiment the cosmetic formulation com foods, nutritional Supplements and other products as prises a protic solvent. In another embodiment the cosmetic described below. formulation contains bioactive glass which has components US 2007/0275021 A1 Nov. 29, 2007

within the following ranges on a % weight basis: 40-60% include bioactive glass is particularly useful in formulations SiO; 10-30% CaO; 10-35% NaO; 2-8% P.O; 0-25% which require topical application. CaF: 0-10% B.O.; 0-8% KO; and 0-5% MgO. Methods of Making 0.043 Cosmetic formulations in accordance with the 0051. The present invention also provides a method of present invention can be well preserved using bioactive making cosmetic compositions comprising bioactive glass. glass, without having to add skin-irritating cytotoxic and An effective antimicrobial amount of the bioactive glass is possibly allergen producing chemical preservatives to the added to or included in a cosmetic formulation. An "effec preparation. Furthermore, an additional nurturing effect may tive, antimicrobial amount of bioactive glass” refers to a be achieved through the antimicrobial and inflammation Sufficient amount of bioactive glass having an appropriate inhibiting effect of bioactive glass. The anti-inflammatory particle size to effectively prevent or control microbial effects of bioactive glass make it particularly useful in skin contamination. The amount and particle size of bioactive care formulations by promoting reductions in irritation, glass to include in a cosmetic formulation will vary depend itching, redness and rashes. ing on the desired length and degree of purity as well as the 0044) In special cases it might be desirable to add the anticipated microbial challenge. An "effective antimicrobial preservative in accordance with the present invention to amount of bioactive glass' also may refer to a Sufficient preparations which have been preserved using standard amount of an aqueous extract of bioactive glass to effec preservatives in order to achieve synergetic effects. tively prevent or control microbial contamination. An “effective antimicrobial amount of bioactive glass may also 0045 Bioactive glass has the ability to react with aqueous refer to a combination of particulate bioactive glass and Solutions (i.e., human perspiration, humidity, body fluids) to aqueous extract of bioactive glass to effectively prevent or elicit biological effects such as anti-microbial/antibacterial control microbial contamination. behavior, UV screening, anti-inflammatory behavior, min 0052 Bioactive glass may be added to or included in eralogical film forming, and therapeutic release of inorganic cosmetic formulations using, for example, techniques or ions. These effects are considered advantageous for many combinations of techniques such as general mixing with cosmetic applications, and several examples of cosmetic slow medium, moderate, or even vigorous agitation. Sufi formulations that can be used to include bioactive glass cient agitation should be provided to achieve relative homo and/or sol-gel-derived bioactive glass within a cosmetic geneity. Preferably, mixing and agitation will avoid exces product are described herein. sive aeration and will have a low sheer rate. In addition, 0046 Bioactive glass forms a hydroxy carbonate layer antifloculants may be used to keep the particles from clump (HCA) on protein-containing Surfaces such as hair, skin, ing together. Other methods or combinations of methods of nails and teeth. This HCA layer can desensitize teeth, blending, dispersing, mixing, combining and/or emulsifying harden/thicken nails, protect skin and modify hair texture. may be utilized. Agitation may be achieved, for example, with standard mixing devices. General mixing and blending 0047 Bioactive glass and/or sol-gel-derived bioactive may be achieved, for example, with an impeller. glass may be effective at absorbing and scattering visible and 0053. It has been unexpectedly discovered that for many UV light, making these materials attractive for soft focus cosmetic base formulations, bioactive glass is easier to and Sun-screening applications. homogeneously mix than other common inorganic powders, 0.048. In one embodiment cosmetic products comprise Such as titanium dioxide and Zinc oxide powder, for sol-gel derived bioactive glass. The sol-gel-derived bioac example. tive glass is extremely porous, and thus effective at Scatter 0054 Bioactive glass may be added to or included in ing visible and UV light. The scatter of visible light is virtually any known cosmetic formulation. Applicants important for soft focus cosmetic products, which are anticipate as well that bioactive glass will be suitable for intended to scatter light from the skin in Such a way that skin inclusion in any as yet to be developed cosmetic formula wrinkles become less visible to the human eye. Further, the tion. In one embodiment the bioactive glass may be particu scatter of UV light is important for Sunscreen products. late. In another embodiment the bioactive glass may be an Thus, the sol-gel-derived bioactive glass is effective at aqueous solution derived from particulate bioactive glass. In scattering UV light in the UVA and UVB regions of the solar still another embodiment the bioactive glass may be a spectrum and provides a soft focusing effect. combination of particulate bioactive glass and an aqueous 0049 Further, the sol-gel-derived bioactive glass reacts Solution derived from bioactive glass. with aqueous solutions to form a solution that becomes 0055 Applicants have unexpectedly discovered that bio concentrated in calcium, phosphate anions and soluble active glass mixed with oil forms a cream. Likewise, bio silica. When this solution becomes saturated, it can form a active glass mixed with water unexpectedly forms a cream. mineralogical, HAp-rich layer on the to Surrounding human The cream resulting from mixing bioactive glass with either tissue. Thus, the sol-gel-derived bioactive glass is expected oil or water possesses a consistent homogenized texture to be effective in soft focus products because it is effective particularly Suitable for cosmetic formulations. at scattering visible light, and the precipitation of the min eralogical layer could act as a skin-tightening agent that 0056. Applicants have unexpectedly discovered that a would further aid in hiding skin wrinkles. combination of bioactive glass with standard skin creams give the skin a pleasant-non-oily feeling and look when 0050. It should also be noted that in addition to bioactive compared with the same cream applied without the added glass, antibiotics may also be added to cosmetic formula bioactive glass. Without being bound to any mechanism, it tions. The addition of antibiotics to cosmetic products which is believed that the bioactive glass has an affinity for oils as US 2007/0275021 A1 Nov. 29, 2007

well as water and protenaceous matter, which is consistent based buffers to the same Suspension, which do not maintain with the unexpected effect observed by which bioactive pH levels for suitable periods of time. Thus, citric acid is one glass and oil form a smooth, homogeneous cream consis preferred method of buffering aqueous based solutions with tency. Thus bioactive glass is Suitable as an effective treat bioactive glass. Bioactive glass is especially useful in an ment for oily/fatty skin. aqueous containing formulation when the formulation is 0057 Bioactive glass and sol-gel derived bioactive glass appropriately buffered to ensure that the pH remains near exhibit many desirable characteristics that would improve neutral and when the bioactive glass is coated with a cosmetic products. However, the difficulty lies in formulat hydrophobic material that prevents the glass from reacting ing the cosmetic products in Such a way that the bioactive while in formulation. glass and/or sol-gel-derived bioactive glass remain unre 0063. In another embodiment the bioactive glass and/or acted (passive) while packaged, and then become reactive sol-gel-derived bioactive glass can be formulated into a dry (active) when applied onto the human body. form incorporating other ingredients, for example colorants 0.058 Bioactive glass and sol-gel-derived bioactive glass and fragrances, and packaged in Small packets or caches for react with aqueous solutions, but are inert when immersed in single use cosmetic products for skin, hair or nail applica anhydrous liquids. Thus, bioactive glass and/or sol-gel tions, for example. The dry form may be a powder. derived bioactive glass may be formulated in liquids, pastes, gels or creams that are anhydrous, but water-soluble (or 0064. The following raw materials listed in Table 1 were water permeable). In this instance, the bioactive glass mixed with bioactive glass and produced stable composi remains un-reacted while immersed in the anhydrous liquid, tions. paste, gel or cream, but would be activated when applied to the human body and allowed to react with perspiration, TABLE I humidity, and/or other aqueous-containing bodily liquids. Raw Materials Combined with Bioactive Glass 0059. In one embodiment, bioactive glass and/or sol-gel Raw Material derived bioactive glass for cosmetic products are used in a Incromectant AQ dispensing system containing two separate vessels (i.e., Promyristyl PM-3 similar to the dispensing system used for an epoxy). The Dermo DPG-2B Transcutol CG bioactive glass and/or sol-gel-derived bioactive glass may be Octyl Methoxycinnamate could be formulated in an anhydrous liquid, paste, cream or Crodafos N3N gel within one vessel, while an aqueous liquid, past, cream Triethanolamine Menthyl Anthranilate or gel may be contained within the second vessel. Mineral Oil Incrodet TD7C 0060. In another embodiment bioactive glass and/or sol Polyderm PPI SiWI gel-derived bioactive glass are mixed with an anhydrous PEG2 Oleamine liquid, paste cream or gel that evaporated or is metabolized Crodafos CAP into the skin after being applied to the body. The anhydrous Plantaren APB liquid, paste, cream or gel protects the bioactive glass while Polyderm PPI SIWS Finsolv TN in the cosmetic package, yet disappears once applied to the Crodasinic O body, thus allowing the bioactive glass to react with perspi Dermo B-246 ration, humidity, and/or other aqueous-containing body liq GE 12O2 uids. Crovol A-40 Crowo A-70 GE SF 96 350 cps 0061. In yet another embodiment, the desirable charac Probutyl 14 teristics associated with bioactive glass and/or sol-gel-de Foamtaine CABG rived bioactive glass are achieved by utilizing an aqueous Dermol MS extract of derived from bioactive glass. The bioactive glass PPG 10 Cetyl ether and/or sol-gel-derived bioactive glass may be reacted with PEG 7 Glyceryl Cocoate d-Limonene an aqueous solution until the solution became saturated with Oleth-3 calcium, phosphate anions and soluble silica. This solution Stepancquat ML could then be filtered, buffered to an appropriate pH, and Ammonium Lauryl Sulfate Incromectant LQ then added to cosmetic formulations to develop cosmetic Tergitol NP-9 products in accordance with the present invention. In this Coco Hydroxy Sultaine embodiment, the formulation may contain aqueous cosmetic Crodesta SL-40*** ingredients, since there would be no solid bioactive glass or POE20 Sorbitan monooleate sol-gel-derived bioactive glass available for reaction. Propylene Glycol Ethanol Na Laureth-2 Sulfate 0062. In many cosmetic applications it is desired that the Sorbitan Isostearate product have pH value of between 5 and 8. Maintaining this Glycerin pH level with bioactive glass in an aqueous Suspension, Procetyl AWS however, is difficult as the glass will continuously react in Crodafos SG Solution, increasing the pH value. Applicants have discov Glycerox 767 Cocamide DEA ered that as little as 1% citric acid can effectively buffer Jojoba Oil bioactive glass toward more neutral pH values over a long Abil EM-90 period in an aqueous Suspension. This is to be contrasted with the effect of adding a standard buffer, such as HCL US 2007/0275021 A1 Nov. 29, 2007

0065. The following raw materials listed in Table 2 were mixed with Sol-gel-derived bioactive glass and produced TABLE III-continued stable compositions. Anhydrous Cosmetic Ingredients Combined with Bioactive Glass TABLE II Cosmetically acceptable Alcohols - including, but not limited to the following: Raw Materials Combined with Sol-Gel-Derived Bioactive Glass Raw Material Ethanol Sopropanol Dermol MS n-propanol PPG 10 Cetyl ether auryl alcohol PEG7 Glyceryl Cocoate oleyl alcohol d-Limonene Cosmetically acceptable Esters - including, Oleth-3 but not limited to the following: Stepancquat ML Ammonium Lauryl Sulfate sopropyl Myristate incromectant LQ sopropyl Palmitate Tergitol NP-9 ojoba Oil Coco Hydroxy Sultaine Glyceryl tri caprate caprylate Crodesta SL-40 Propylene glycol di caprate? caprylate POE20 Sorbitan monooleate Sorbitan Esters Propylene Glycol Diesters of diacids Ethanol Cosmetically acceptable Ethoxylated Materials - including, Na Laureth-2 Sulfate but not limited to the following: Sorbitan Isostearate Glycerin hoxylated Fatty Alcohols Procetyl AWS hoxylated Fatty Acids Crodafos SG hoxylated Sorbitan Esters hoxylated Glycerides osmetically acceptable Propoxylated Materials - including, ojoba Oil but not limited to the following: incromectant AQ Foamtaine CABG (45%) Propoxylated Fatty Alcohols Promyristyl PM-3 Propoxylated Fatty Acids Abil EM-90 sters of Propoxylated Fatty Alcohols Dermo DPG-2B hoxylated Propoxylates Transutol CG : osmetically acceptable anhydrous ionic Surfactants - including, Octyl Methoxycinnamate but not limited to the following: Crodafos N3N Triethanolamine Phosphate esters Menthyl Anthranilate Sulfaters Mineral Oil Carboxylates Incrodet TD7C Fatty amine salts Polyderm PPI SiWI Quaternary nitrogen salts PEG2 Oleamine Cosmetically acceptable mineral, vegetable and Crodafos CAP animal derived oils and fats. Plantaren APB Cosmetically acceptable silicones including, Polyderm PPI SIWS but not limited to the following: Finsolv TN Crodasinic O Dimethicone Dermo B-246 Simethicone GE 12O2 Cyclomethicone Crovol A-40 Dimethicone ethoxylates and propoxylates Crowo A-70 Cosmetically acceptable fluorocarbons and derivatives - including, GE SF 96 (350 cps) but not limited to the following: Probutyl 14 Zonyls Fluorcarbon alcohols Cosmetically acceptable aerosol propellants - including, 0.066 Bioactive glass, including sol-gel derived bioactive but not limited to the following: glass may be combined with anhydrous cosmetic ingredients Propane to created Stable, non-irritating cosmetic formulations. A list Butane of exemplary anhydrous ingredients is provided in Table III. Pentane Sobutane TABLE III HFC, CFC, HCFC Anhydrous Cosmetic Ingredients Combined with Bioactive Glass Cosmetically acceptable Glycols - including, 0067 Bioactive glass, including sol-gel derived bioactive but not limited to the following: glass may be combined with anhydrous and hydrous cos Glycerin metic ingredients to created stable, non-irritating cosmetic Propylene Glycol formulations. Anhydrous and hydrous cosmetic ingredients Butylene Glycol Hexylene Glycol may be used in a two-compartment dispensing system. A list 2-methyl propane diol of exemplary anhydrous and hydrous cosmetic ingredients is provided in Table IV. US 2007/0275021 A1 Nov. 29, 2007

TABLE IV TABLE IV-continued Anhydrous and Hydrous Ingredients Which May Be Used in a Anhydrous and Hydrous Ingredients Which May Be Used in a Two-Compartment Dispensing System Two-Compartment Dispensing System Cosmetically acceptable Glycols - including, Polyoxypropylenes but not limited to the following: Polyamides Polyesters Glycerin Polyurethanes Propylene Glycol Cellulosics and derivatives Butylene Glycol Polyacrylics Hexylene Glycol Polymethacrylics 2-methyl propane diol Polysiloxanes Cosmetically acceptable Alcohols - including, Cosmetically acceptable copolymers but not limited to the following: Cosmetically acceptable cosmetic formulation bases - including, but not limited to the following: Ethanol Sopropanol Emulsifying Waxes n-propanol Lubrajels auryl alcohol Zilgels oleyl alcohol oioba Glaze Cosmetically acceptable Esters - including, Absorption Bases but not limited to the following: sopropyl Myristate sopropyl Palmitate ojoba Oil 006.8 Bioactive glass, including sol-gel derived bioactive Glyceryl tri caprate caprylate glass also may be combined with cosmetic ingredients Propylene glycol di caprate? caprylate which evaporate shortly after being applied to the skin. Such Sorbitan Esters Diesters of diacids combinations may used to create stable, non-irritating cos Cosmetically acceptable Ethoxylated Materials - including, metic formulations. A list of exemplary cosmetic ingredients but not limited to the following: which may evaporate after being applied to the skin is hoxylated Fatty Alcohols provided in Table V. hoxylated Fatty Acids hoxylated Sorbitan Esters TABLE V hoxylated Glycerides osmetically acceptable Propoxylated Materials - including, Evaporating Ingredients but not limited to the following: Cosmetically acceptable Alcohols - including, Propoxylated Fatty Alcohols but not limited to the following: Propoxylated Fatty Acids sters of Propoxylated Fatty Alcohols hoxylated Propoxylates Sopropano : osmetically acceptable anhydrous ionic Surfactants - including, n-propano but not limited to the following: Cosmetically acceptable Esters - including, but not limited to the following: Phosphate esters Sulfaters Ethyl acetate Carboxylates Butyl acetate Fatty amine salts Cosmetically acceptable Ethoxylated Materials - including, Quaternary nitrogen salts but not limited to the following: Cosmetically acceptable mineral, vegetable and animal derived oils and fats. Ethoxydiglycol Cosmetically acceptable silicones including, Cosmetically acceptable silicones - including, but not limited to the following: but not limited to the following: Dimethicone Cyclomethicone Simethicone Dimethicone Cyclomethicone Cosmetically acceptable ketones - including, Dimethicone ethoxylates and propoxylates but not limited to the following: Cosmetically acceptable fluorocarbons and derivatives - including, but not limited to the following: Acetone Methyl Ethyl Ketone Zonyls Cosmetically acceptable Aliphatic compounds - including, Fluorcarbon alcohols but not limited to the following: Cosmetically acceptable amides - including, but not limited to the following: n-alkanes branched alkanes Fatty acid diethanolamides Permethyls Fatty acid monoethanolamides Aerosol propellant gases Fatty acid dimethylamnopropylamides Cosmetically acceptable fluorocarbons, chlorofluoro carbons, Cosmetically acceptable Polymers - including, hydro fluoro carbons and hydro chloro fluoro carbons - including, but not limited to the following: but not limited to the following: Polyalkenes Aerosol propellant gases Polyoxethylenes US 2007/0275021 A1 Nov. 29, 2007

0069. One aspect of the present invention will be more methyl gluceth-20, methylparaben, octyl methoxycinamate, clearly understood with reference to the following non panthenol, PEG-7 glyceryl cocoate, petrolatum, phenoxy limiting examples of cosmetic and personal care products ethanol, polydimethylsiloxane-PPG ether/IPDI copolymer, and formulations which are suitable for use with bioactive polysorbate 20, polysorbate 80, propylene glycol, propylpa glass. raben, silicone, sodium PCA, sorbitol, steareth-2, stearic Categories of Cosmetics and Personal Care Health Products acid, tocopheryl acetate, triethanolaminel and witch hazel. 0070 The present invention will produce novel formu 0074 The present invention provides for novel formula lations of a variety of cosmetic and personal care products tions of pigmentation products by incorporating bioactive including but not limited to: pigmentation and Sun care glass into a combination of any of the above-listed ingredi products; diaper, baby wipe and hand wipe, baby powder ents. In addition, bioactive glass itself can act as a pigment. and body powder and diaper rash products; nursing pads (for Also, bioactive glass can be doped with various metals, bras); makeup products; tampon, maxipad and pantiliner including but not limited to iron, cobalt, and/or manganese, products; acne prevention and treatment products; facial to produce a desired pigmentation. cleansing, toning and exfoliating products and makeup Sun Care Products removal products; facial moisturizing, anti-wrinkle, eye treatment, hand lotion and body lotion products; foot care 0075. The present invention includes novel formulations products; anti-itch products; anti-bacterial, antiseptic, anti which incorporate bioactive glass into various brands of Sun biotic and first aid products; bath and shower Soap in bar, care products, such as the products marketed under the brand liquid and gel form and bath salt products; shampoo and hair names A-FIL, Alba Botanica, Aloe Vera 80, Ambrelle, Bain detangling products; hair mousse, hair gel and hair spray de Soleil, Banana Boat, BioSun, Blue Lizard, Brite-Life, products; antiperspirant and deodorant products in powder, Bull Frog, Coppertone. DuraScreen, Elta Block, Esoterica, creme, roll-on, aerosol and stick form; aftershave and shav Flents, Fruit of the Earth, Good Sense, Hawaiian Tropic, ing lotion products; shaving products in creme, gel, powder Jason, Kiss My Face, L.A. Tan, Lily of the Desert, Native and soap forms; depilatory, epilatory and hair bleaching Tan, Nature's Gate, Neutrogena, No Ad, Off, Panama Jack, products in creme, wax and powder forms; toothpaste prod PreSun, Sea & Ski, Shade Sunblock, Sol Bar, Sunbrellas, ucts; mouthwash and mouth rinse products; wig and toupee Sun Splash, Ti-Screen, Water Babies, and products produced powder products; shoulder pads; freckle coating products, by high-end and generic manufacturers. eye drop products; and contact lens treatment products. 0076 Pigmentation and sun care formulations compris ing bioactive glass provide enhanced UV protection as Pigmentation Products compared to formulations not comprising bioactive glass. 0071. The present invention includes novel formulations While not being bound by any specific theory, the high and which incorporate bioactive glass into various brands of irregular Surface area of particulate bioactive glass is pigmentation products, such as the products marketed under thought to contribute to this enhanced UV protection. In the brand names Bain de Soleil, Banana Boat, Coppertone, addition, the reactive glass Surface provides a protective Fruit of the Earth, Good Sense, Hawaiian Tropic, Kiss My HCA layer to offer additional UV protection, Moreover, Face, Neutrogena, and products produced by high-end and these formulations help to mitigate the effects of sun aller generic manufacturers. gies by releasing soluble calcium. Generally, pigmentation products comprise the active ingre 0077 Bioactive glass begins to absorb UV light at wave dient dehydroxyacetone (DHA). lengths below 380 nm, and 0% transmittance was observed 0072 Common formulations of pigmentation products through a polished, 5 mm glass blank for UV light with a comprise water, glycerin, dihydroxyacetone, octyl palmi wavelength below 280 nm. Thus, bioactive glass should be tate, butylene glycol, cetyl alcohol, PPG-20 methyl glucose an excellent sunblock for the UVB (270-320 nm) region, and ether distearate, stearyl alcohol, acrylates/C10-30 alkyl a moderately good sunblock for the UVA (320-400 nm) acrylate crosspolymer, aloe gel, cocoa butter, DEA-cetyl region of Solar radiation. phosphate, dimethicone, disodium EDTA, DMDM hydan 0078. The sun-blocking, effectiveness of bioactive glass toin, eucalyptus oil, fragrance, glyceryl Stearate, iodopropyl should improve as a function of time, after it is applied to butylcarbamate, lanolin, magnesium aluminum silicate, human skin. Bioactive glass is expected to react with human PEG-100 stearate, polysorbate 60, sodium metabisulfite, perspiration to form a porous, mineralogical, HAp-rich Sorbic acid, Steareth-20, Xanthan gum and various vitamin, precipitate at the glass Surface. This porous, Surface precipi mineral, fruit and plant extracts. tate is expected to scatter Solar radiation, thus improving the Sun-blocking characteristics of the bioactive glass with 0.073 Pigmentation products may also include one or reaction time. Thus, bioactive glass is considered an active more of the following: isoceteth-3 acetate, sorbitan isostear Sunscreen ingredient that would improve over time as per ate, polyduaternium-37, glycereth-7 triacetate, dicaprylate/ spiration from the skin would activate the scattering char dicaprate, PPG-1 trideceth-6, bisabolol, PEG-20 methyl acteristics that are associated with the HAp-rich surface glucose sesquistearate, caprylic?capric triglyceride, unasa precipitate. ponifables, benzyl alcohol, butylparaben, C12-15 alcohol benzoate, caprylic/capric, triglyceride, caramel, carbamate/ 0079 The transmittance through a 5 mm thick, polished acrylate copolymer, carbomer, ceteareth-20, ceteth-10, cet sample of bioactive glass that was reacted with tris-buffered eth-2, cetyl hydroxyethylcellulose, citric acid, diazolidinyl saline solution to form a surface precipitate of HAp was urea, dimethyl isosorbide, dipropylene glycol, disodium tested. The transmittance through the pre-reacted bioactive EDTA, emulsifying wax, ethoxydiglycol, ethylparaben, imi glass was found to be less than that through the un-reacted dazolidinyl urea, isoceteth-20, isopropyl palmitate, melanin, bioactive glass at any wavelength from 280 to 600 nm. Thus, US 2007/0275021 A1 Nov. 29, 2007

the HAplayer formed by pre-reaction appears to scatter UV EXAMPLE 2 and visible light, and the bioactive glass should be more effective at blocking UV radiation once it begins to react Composition of Sunscreen Gel with with human perspiration on the skin. Sol-Gel-Derived Bioactive Glass 0080 Generally, sun care products comprise the active 0085 ingredient avobenzone, titanium oxide, Zinc oxide, oxyben Zone, or Sulisobenzone.

0081 Common formulations of sun care products com INGREDIENTS wt % prise octyl methoxycinnamate, octyl salicylate, homosalate, Jojoba Glaze 82.5 benzalkonium chloride, water, PVP/eicosene copolymer, Octyl Methoxycinnamate 7.5 dioctyl phosphate, triethanolamine, cetyl alcohol, retinyl Benzophenone-3 S.O palmitate, oat extract, tocopherol acetate, panthenol, dime Schott Glass sol-gel-derived bioactive glass S.O thicone, trimethylsiloxysilicate, bisabolo, disodium EDTA, Sorbitan isostearate, butylene glycol, phenoxyethanol, car bomer, Xanthan gum and diasolidinyl urea. 0082 Sun care products may also include one or more of the following: PVP/hexadecene, isopropyl myristate, 2-eth EXAMPLE 3 ylhexyl salicylate, acrylates/C10-30 alkyl acrylate cross polymer, acrylates/octylacrylamide copolymer, aloe extract, Composition of Sunscreen Gel Formulas CPD3-32, aluminum stearate, avobenzone (parsol 1789), barium sul J, K, N, O, R, S fate, benzophenone-3, benzyl alcohol, butylcarbamate, C12 0086) 15 alkyl benzoate, ceteareth-20, cetearyl alcohol, cetyl palmitate, cyclomethicone, DEA-cetyl phosphate, DMDM hydantoin, edetate disodium, elastin, emulsifying wax NF, ethylhexyl P-methoxycinnamate, fluoroalkyldimethicone, Sunscreen Base Formula fragrance, glyceryl monostearate-450, glyceryl Stearate SE, hydrolyzed collagen, hydroxypropyl cellulose, imidazolidi INGREDIENTS % nyl urea, iodopropynyl, isohexadecane, isopropyl palmitate Jojoba Glaze 87.5 (palm oil), jojoba oil, menthyl anthranilate, methylparaben, Octyl Methoxycinnamate 7.5 mineral oil, octadecene/MA copolymer, octocrylene, octyl Benzophenone 3 S.O palmitate, octyldodecy neopentanoate, oxybenzone, paraf fin, petrolatum, phenethyl alcohol, phenylbenzimidazole 1OOO sulfonic acid, polyglyceryl-3 distearate, PPG-12/SMDI copolymer, PPG-15 stearyl ether, proplyene glycol, propy Formulas to be tested lparaben, PVP/hexadecene, SD alcohol 40, shea butter, silica, Sorbitan sesquioleate, Sorbitol, Stearic acid, StearoX CPD3-32 J=Sunscreen Base Formula (above), SPF-15 ytrimethylsilane, stearyl alcohol, titanium dioxide, tribehe nin, trifluoromethyl C1-4 and zinc oxide. CPD3-32 K=Jojoba Glaze, SPF-0 0083. The present invention provides for novel formula CPD3-32 N=Sunscreen Base Formula-2% 45s, d50=11.6. tions of Sun care products by incorporating bioactive glass CPD3-32 O=Sunscreen Base Formula-2% 58s, d50=0.77u into a combination of any of the above-listed ingredients. Examples 1-3 below provide exemplary embodiments of sun CPD3-32 R=Sunscreen Base Formula+4% 45s, d50=11.6. care formulations incorporating bioactive glass, including sol-gel-derived bioactive glass. CPD3-32 S=Sunscreen Base Formula+4% 58s, d50=0.77u Diaper, Baby Wipe and Handwipe, Baby Powder and Body EXAMPLE 1. Powder Products, and Diaper Rash Products Composition of Sunscreen Gel with Bioactive 0087. The present invention includes novel formulations Glass which incorporate bioactive glass into various brands of diaper, baby wipe and hand wipe, baby powder and body 0084) powder products such as the products marketed under the brand names A&D, Aloe Vesta, Alpharma, Ammens, Aveeno, Baby Magic, Balmax, Borofax, Boudreaux's, Brite Life, Burt’s Bees, Caldesene, Calmoseptine, Cashmere Bou INGREDIENTS wt % quet, Cetaphil, Chubbs, Clinipad, Comfort Bath, Cottonelle, Jojoba Glaze 82.5 Desitin, Diaparene, Diaper Doubler, Diaper Guard, Dr. Octyl Methoxycinnamate 7.5 Smith's, Drypers, Flander's, Fougera, Gerber, Gold Bond, Benzophenone-3 S.O Goodnites, Good Sense, G&W. Huggies, Johnson & Schott Glass Bioactive Glass (<4 ave. part. size) S.O Johnson, Kid Fresh, Kleenex, Little Bottoms, Little Forest, Luvs, Mexsana, Nature Boy & Girl, Neutrogena, Nice N Clean, Paladin, Pampers, Phisoderm, Playtex, Pull Ups, Pure N Gentle, Purell, Shower to Shower, Smiles, Suave, US 2007/0275021 A1 Nov. 29, 2007

Sween, Tom's of Maine, Tushies, Vaseline, Wash-Up, 0098. The present invention provides for novel formula Weleda, Wet Ones, and products produced by high-end and tions of baby powder and body powder products by incor generic manufacturers. porating bioactive glass into a combination of any of the 0088. The anti-inflammatory, antimicrobial, and hygro above-listed ingredients. scopic properties of bioactive glass are particularly useful in 0099 Generally, diaper rash products comprise zinc diapers, baby powders, body powders, diaper rash products oxide and fish or cod liver oil. and moist towelettes to reduce inflammation, rash and odors. 0.100 Common formulations of diaper rash products In addition, bioactive glass can reduce the acidity of urine comprise petrolatum, lanolin, cod liver oil, fragrance, min and is activated by the aqueous nature of urine. eral oil, microcrystalline wax and paraffin. 0089 Generally, diaper products comprise synthetic or 0101 Diaper rash products may also include one or more natural absorbent materials which absorb moisture, synthetic of the following: balsam, benzoic acid, water, bismuth materials which prevent leakage, and fragrance and/or anti Subnitrate, borax, silicone, methylparaben, talc, trihydrox bacterial agents. yStearin, bisabolol, polyparaben and imidazolidinyl urea. 0090 The present invention provides for novel formula tions of diaper products by incorporating bioactive glass into 0102) The present invention provides for novel formula a combination of any of the above-listed ingredients. In tions of diaper rash products by incorporating bioactive addition, bioactive glass may be used in so-called adult glass into a combination of any of the above-listed ingredi brand diaper products. entS. 0.091 Generally, baby wipe or hand wipe products com 0103) The antimicrobial, anti-inflammatory, and hygo prise the active ingredient disodium cocoamphodiacetae, a scopic properties of bioactive glass are particularly useful in protectant such as silicon oil, mineral oil, fatty acids, fatty diaper rash products to reduce inflammation, rash and odors. alcohols or plant oils, and a moisturizer Such as aloe gel. Nursing Pads (for Bras) propylene glycol and PEG-60. 0.104 Bioactive glass may also be incorporated into vari 0092 Common formulations of baby and hand wipe ous brands of nursing pad (for bras), including nursing pads products comprise water, propylene glycol, PEG-75 lanolin, marketed under the brand names Curity, Healthflow, Gerber, cocoamphodiacetate, polysorbate 20, methylparaben, Johnson's, Evenflo, Omron, and products produced by high 2-bromo-2-nitropane-1,3-diol, propylparaben, aloe Vera gel end and generic manufacturers. and fragrance. 0105 The antimicrobial and anti-inflammatory effects of 0093 Baby and hand wipe products may also include one a bioactive glass are particularly useful in nursing pads or more of the following: cocamidopropyl PG-dimonium (bras) to reduce inflammation, rash and odors. chloride phosphate, acrylates/C10-30 alkyl acrylate cross polymer, acetamidopropyl trimonium chloride, acrylates Makeup Products copolymer, alkyl polyglycoside, aminomethyl propanol, 0106 The present invention includes novel formulations benzalkonium chloride, benzoic acid, C12-15 alkyl ben which incorporate bioactive glass into various brands of Zoate, citric acid, diazolidinyl urea, dimethicone, disodium makeup products including mascara, eyeshadow, eyeliner EDTA, disodium phosphate, DMDH hydantoin, ethyl alco and eyebrow pencil, blush, concealer foundation, face pow hol, glycerin, isopropyl myristate, malic acid, nonoxynol 9, der, lipstick, lip gloss, lip treatment, lipliner, nail polish and oleth-20, phosphate, phospholipid CDM, phospholipid EFA, nail polish remover products such as the products marketed polyaminopropyl biguanide, potassium laureth phosphate, under the brand names Almay, Alpha Hydrox, Aromathera potassium Sorbate, retinyl palmitate, SD alcohol 40, sim paes, Bari, Black Radiance, Blistex, Bonnie Bell, Brite-Life, ethicone, Sodium benzoate, Sodium nonoxynol-9, Sorbic Burt’s Bees, Caboodles, Carmex, Chap-et, ChapStick, Chat acid, tetrasodium EDTA, tocopherol acetate and various term, Clinipad, Coty, Cover Girl, Curity, Cutex, Dermatone, Vitamin and plant extracts. Garden Botanika, Herpecin-L, Jane, Jason, Kid Care, 0094. The present invention provides for novel formula L'Oreal, Liquimat, Loud Music, M Professional, Max Fac tions of baby and hand wipe products by incorporating tor, Maybelline, Milani, Natural Ice, Neutrogena, Noxzema, bioactive glass into a combination of any of the above-listed Ocusoft, Oil of Olay, Orly, Petersons, Purpose, Revlon, ingredients. Sally Hansen, Savex, Softlips, Stay Free, Tampax, United Colors of Benetton Cosmetics, Ultimates, Vaseline, Viractin, 0.095 Generally, baby powder and body powder products Wet 'n' Wild, Woltra, Zilactin, and products produced by comprise talc and/or corn starch, Zinc oxide and fragrance. high-end and generic manufacturers. 0.096 Common formulations of baby powder and body 0.107 The anti-inflammatory and antimicrobial effects of powder products comprise corn starch or talc, sodium bicar bioactive glass are particularly useful in makeup products to bonate, aloe Vera gel, tricalcium phosphate and fragrance. reduce bacteria and inflammation. 0097 Baby powder and body powder products may also include one or more of the following: tricalcium phosphate, 0.108 Generally, mascara products comprise talc, a wax bentonite (natural clay), kaolin clay, polysaccharides, puri product, a preservative and coloring agents. fied rice bran flour, silica, Zinc oxide, hydroxyquinoline, 0.109 Common formulations of mascara products com 8-hydroxyquinoline sulfate, isostearic acid, PPG-20, methyl prise water, beeswax, cyclopentasilosane, glyceryl Stearate, glucose ether, magnesium carbonate, Zinc Stearate, camphor, PPG-17 copolymer, carnuba wax, stearic acid, paraffin, benzalkonium chloride and various fruit, mineral, Vitamin butylene glycol, EDTA, polyethylene, nylon-12, polymeth and herbal extracts. ylmethacrylate, PVP copolymer, PVP silica, triethanola US 2007/0275021 A1 Nov. 29, 2007 mine, synthetic wax, hydrolyzed corn starch, panthenol, oxides, ferric ferrocyamide, ferric ammonium ferrocyamide, dimethiconol, isoceteth-20, hydroxyethyl cellulose, diaz carmine, polyglyceryl-3 diisoStearate, hydrogenated coco olidyl urea, methylparaben, simethicone, butylparaben, glycerides, ethylene/methacrylate copolymer, nylon-12, disodium octylacrylamide/acrylates/butyl aminoethyl meth pentahydrosqualene, acrylates copolymer, polyglycery-4 acrylate copolymer, cocoamphodiacetate, tocopheryl isostearate, laurylmethicone copolyol, perfluoropolymeth acetate, isopropyl titanium triisostrearate, lecithin, triethy yliospropeth phosphate, butylparaben, phenoxyethanol and lamine, 2-oleamido-1,3-octadecanediol and propylparaben. various coloring agents. 0110 Mascara products may also include one or more of 0115 The present invention provides for novel formula the following: mica, TEA-Stearate, glyceryl Stearate, tricon tions of eyeshadow products by incorporating bioactive tanyl PVP, silk powder, diglycol/CHDM/lsophthalates/sip glass into a combination of any of the above-listed ingredi copolymer, PTFE, stearate, sorbitan laurate, polysorbate 20, entS. acacia, acrylates copolymer, alcohol denatured, aminom ethyl propandiol, ammonium acrylates copolymer, ammo 0116 Generally, eyeliner and eyebrow pencil products nium hydroxide, ammonium lanolate, ascorbyl palmitate, comprise talc, mica, polyethylene, fluorethylene, magne benzyl alcohol. BHA, butyl stearate. C9-11 isoparaffin, sium Stearate and coloring agents. candelilla wax, carmine, cetyl alcohol, cetyl Stearate, chro 0.117) Common formulations of eyeliner and eyebrow mium hydroxide green, citric acid, cyclomethicone, ethylpa pencil products comprise cyclomethicone, synthetic bees raben, fragrance, glycerin, glyceryl rosinate, hydgroplex wax, arachidyl behenate, microcrystalline wax, quaternium Hhg Whn, hydrolyzed keratin, hydroxyethylcellulose, imi 18 hectorite, mineral oil, propylene carbonate, methylpara dazolidinyl urea, iron oxides, kaolin, magnesium aluminum ben, propylparaben and BHT. silicate, methyl ethyl propylbutylparabens/phenoxyethanol, 0118 Eyeliner and eyebrow pencil products may also MIPA-lanolate, MIPA-oleate, nnoxynol-10, oleic acid, oleyl include one or more of the following: PPG-2 myristyl ether alcohol, PEG-100 stearate, pentaerythrity1 tetrastearate, phe propionate ceresin, castor oil, vegetable oil, lanolin, alumi noxyethanol, polybutene, polyethylene, polyduaternium 10, num powder, bronze powder, copper powder, Zinc oxide, polyvinyl alcohol, potassium Ocotxynol-12, phosphate, pro aluminum powder, ammonium hydroxide, ascorbic acid, pylene carbonate, propylene glycol, propyl, quaternium-15. ascorbyl palmitate, benzyldimethylstearylammonium hec quaternium-18, hectorite, quaternium-22, SD alcohol 40-B, torite. BHA, bismuth oxychloride, butyl stearate, butylene silica, silk powder, sodium dehydroacetate, Sodium laureth glycol, butylparaben, candelilla wax, caprylic/capric acid sulfate, sodium lauryl Sulfate, sodium polymethacrylate, triglyceride, carmine, carnaubacetyl alcohol, carnauba wax, Sorbitan sesquioleate, talc, titanium dioxide, triclosan, trim ceresin, cerotic acid, cetyl alcohol, cetyl esters, cetyl palmi ethylsiloxysilicate, trisodium EDTA, ultramarines and Xan tate, chromium hydroxide green, chromium oxide greens, than gum. citric acid, diazolidinyl urea, dimethicone, ferric ammonium 0111. The present invention provides for novel formula ferrocyamide, fish glycerides, glycerin, hydrogenated castor tions of mascara products by incorporating bioactive glass oil, hydrogenated coco-glycerides, hydrogenated cottonseed into a combination of any of the above-listed ingredients. oil, hydrogenated fish oil, hydrogenated palm glycerides, hydrogenated vegetable oil, hydroxyethylcellulose, 0112 Generally, eyeshadow products comprise talc, hydroxylated lanolin, ipphilic glyceryl monooleate, iron mica, polyethylene fluorethylene, magnesium Stearate and oxides, isopropyl C12-15-pareth-9 carboxylate, japan wax, coloring agents. lipophilic glyceryl monostearate, manganese violet, mellisic 0113 Common formulations of eyeshadow products acid, methyl polysiloxane, mica, myricyl alcohol, oleoStear comprise cyclomethicone, talc, boron nitride, trimethylsi ine, ozokerite, paraffin, parahydroxybenzoate ester, PEG-8, loxysilicate, polyethylene, synthetic wax, microcrystalline polyethylene, polysorbate 60, PPG-15, PPG-5 eteth-20, PVP wax, Zinc Stearate, kaolin, dimethicone, retinyl palmitate, laureth-4, quaternium-18 bentonite, Saturated fatty acid tocopheryl acetate, aloe extract, silk powder, silica PTFE, glycerides, silica, Sorbitan Stearate, soybean phospholipid dehydroacetic acid, methylparaben, propylparaben, ethylpa Soybean lecithin, Stearic acid, Stearyl heptanoate, styrene? raben and diazolidinyl urea. acrylates copolymerm, talc, tallow glyceride, titanium diox 0114 Eyeshadow products may also include one or more ide, tocopheryl acetate, tristearin, ultramarines, various min of the following: ascorbyl palmitate, beeswax, benzyldim eral, vitamin, water, Zinc Stearate and various vegetable and ethylstearylammonium hectorite, BHT, bismuth oxychlo plant extracts. ride, C12-C15 alkyl benzoate, calcium silicate, candelilla 0119) The present invention provides for novel formula wax, caprylic/capric acid try glyceride, carnauba wax, chro tions of eyeliner and eyebrow pencil products by incorpo mium hydroxide green, chromium oxide greens iron oxides, rating bioactive glass into a combination of any of the citric acid, coco caprylate caprate, D1 tocopherol, hydroge above-listed ingredients. nated oil, hydroxylated lanolin, imidazolidinyl urea, isopro pyl trisoStearoyl titanate, lauroyl lysine, lauryl lysine, leci 0120 Generally, blush products comprise talc, a preser thin, lipophilic glyceryl monostearate, magnesium Vative, an emollient, and coloring agents. carbonate, manganese violet, methyl polysiloxane, mica, 0121 Common formulations of blush products comprise mineral oil, octyldodecyl Stearoyl Stearate, paraffin, parahy dimethicone, octyl palmitate, talc, nylon-12, neopentylgly droxybenzoate ester, polymethyl methacrylate, polyvi col diisooctanoate, tribehenin, isostearyl behenate, boron nylidene copolymer, propylene carbonate, quaternium-15. nitride, acrylates copolymer, tocopherol, retinyl palmitate, saturated fatty acid glycerides, sodium dehydroacetate, Soy methoxypropylgluconamide, chitin extract, sodium hyalur bean phospholipid soybean lecithin, Stearic acid, titanium onate, hydrolyzed glucosaminoglycans, lecithin, candelilla dioxide, trilaurin, trioctanion, ultramarines, Zinc oxides, iron wax, soy amino acids, mimosa wax, pentahydrosqualene, US 2007/0275021 A1 Nov. 29, 2007

Sorbitan trioleate, water, propylene glycol, silica, phenoxy rate, hydrogenated coco-glycerides, hydrogenated poly ethanol, titanium butylparaben, isopropylparaben, isobu isobutane, imidazolidinyl urea, iron oxides, isocetyl Stearate, tylparaben, BHA, lauryl lysine and methyldihydroias isododecane, isooctahexacontane, isopropyl isoStearate, iso monate. propyl palmitate, isopropyl titanium triisoStearate, isostearyl 0122 Blush products may also include one or more of the neopentanoate, isostearyl palmitate, kaolin, lanolin, lanolin following: acetylated lanolin alcohol, allantoin, ascorbyl alcohol, lanolin oil, laureth-7, lauroyl lysine, lecithin, lipo palmitate, barium sulfate. BHT, bismuth oxychloride, philic glyceryl monostearate, magnesium aluminum silicate, butylparaben, C12-15, alkylbenzoate, calcium silicate, cam magnesium carbonate, magnesium Sulfate, methicone, phor, carbomer, carmine, cethyl acetate, clove oil, coco methyl glucose sesquistearate, methyl polysiloxane, mica, caprylate caprate, diazolidinyl urea, ethylparaben, eucalyp mineral oil, myristyl lactate, octamethyl cyclotetrasiloxane, tus oil, ferric ammonium ferrocyamide, ferric ferrocya midea, fragrance, imidazolidinyl urea, iron oxides, kaolin, octyl methoxycinamate, octyl palmitate, octyl salicylate, manganese violet, menthol, methylparaben, mica, midazo octyl Stearate, octyldodecanol, octyldodecy neopentanoate, lidinyl urea, mineral oil, oat flour, octyldodecyl Stearoyl octyldodecyl Stearoyl Stearate, oZokerite, panthenol, pectin, Stearate, panthenol, polyethylene, polyoxymethylene urea, PEG-100 stearate, PEG-2 stearate, PEG-20 sorbitan bees polysorbate 20, polysorbate 80, quaternium-15, sodium wax, PEG-32, PEG-6, PEG-8, petrolatum, phenyl dimethi dehydroacetate, tetrasodium editapropylparaben, tin oxide, cone, polyethylene, polyglyceryl-4 isostearate, polyglyc titanium dioxide, triethanolamine, trimethylsiloxysilicate, eryl-6, ricinoleate, polyisobutene, polysorbate 60, propylene trioctanion, ultramarines, various coloring agents, various glycol, PVP quaternium-18 hectorite, SD alcohol 40b, silk plant extracts, Zinc Stearate, hydrogenated coco-glycerides, powder, sodium chloride, sodium dehydroacetate, sodium octyl hydroxyStearate, ultramarines and various coloring hyaluronate, Sodium lauroyl sarcosinate, Sorbic acid, Sorbi agents. tan sesquioleate, Stearic acid, Stearoxytrimethylsilane, 0123 The present invention provides for novel formula Stearyl alcohol, Stearyl Stearoyl Stearate, t-butyl hydro tions of blush products by incorporating bioactive glass into quinone, tetrasodium EDTA, titanium dioxide, tocopheryl a combination of any of the above-listed ingredients. linoleate, tricontanyl PVP triethanolamine, trihydroxys 0124 Generally, concealer and foundation products com tearin, trimethylsiloxysilicate, trisodium EDTA, tristearin, prise isoeicosane, carnauba, polyglyceryl-3 diisoStearate, ultramarine blue, va/vinylbutylbenzoate, Xanthumgum and Silica, titanium oxide and coloring agents. various coloring agents. 0125 Common formulations of concealer and foundation products comprise water, butylene glycol, dimethicone, 0127. The present invention provides for novel formula isostearyl alcohol, synthetic wax, cyclomethicone, PEG-20 tions of concealer and foundation products by incorporating methyl glucose sesquistearate, sodium Stearate, tribehenin, bioactive glass into a combination of any of the above-listed polymethyl methacrylate, Salicylic acid, hydrolyzed veg ingredients. etable protein, silica, talc, microcrystalline wax, dimethi cone copolyol, polyglyceryl-6-polyricinoleate, aluminum 0.128 Generally, face powder products comprise talc, a Stearate, boron nitride, dimethiconol. diisoStearyl malate, preservative, calcium Stearate, and coloring agents. casein, carrageenan, tocopheryl acetate, retinyl palmitate, 0.129 Common formulations of face powder products aloe extract, ascorbic acids, menthol, calcium chloride, nylon-12, perfluoropolymethylisopropyl ether, methylpara comprise talc, mineral oil, Zinc Stearate, kaolin, aluminum ben, propylparaben and phenoxyethanol. starch octenylsuccinate, acrylates copolymer, silk powder, silica, propylparaben, methylparaben, calcium silicate, imi 0126 Concealer and foundation products may also dazolidinyl urea, iron dioxides and ultramarines. include one or more of the following: paraffin, pentaeryth rity1 tetrastearate, octyl hydroxyStearate, ceteareth-20, set 0.130 Face powder products may also include one or ereth-2, DMDM hydantoin, quaternium-15, dextrin, calcium more of the following: acetylated lanolin alcohol, ascorbyl silicate, Zinc Stearate, octyldodecyl myristate, tridecyl trim palmitate, beeswax, BHT, bismuth oxychloride, camphor, ellitate, bis-digly-ceryl caprylate/capratefisostearate/stea, caprylic/capric triglyceride, carmine, clove oil, cyclomethi glyceryl rosinate, acetylated glycol Stearate, acetylated lano con, dextrin, diazolidinyl urea, dimethicone, ethylene? lin, acetylated lanolin alcohol, acrylates copolymer, alcohol acrylic acid copolymer, ethylparaben, eucalyptus oil, fra denatured, alkyl octanoate, allantoin, aluminum hydroxide, aluminum starch octenylsuccinate, aminoethylpropanol, grance, glyceryl rosinate, hydrogentated lecithin, isopropyl arachidyl behenate, ascorbyl palmitate, barium sulfate, bees palmitate, lauroyl lysine, lecithin, magnesium Stearate, mag wax, bentonite, benzoic acid, BHA, BHT, bisabolol, bisa nesium Sulfate, manganese violet, menthol, methicone, codyl, bismuth oxychloride, butylparaben, C12-15 alcohols methyl-ethyl-propyl-ibutylparabens/phenoxyethanol, mica, octanoate, C12-15 alkylbenzoate, calcium aluminum boro nylon-12, oat flour, octyl palmitate, octyldodecanol Stearoyl silicate, candelilla wax, caprylic/capric triglyceride, car Stearate, octyldodecyl myristate, panthenol, phenoxyetha nauba, castor oil, cellulose gum, cetearyl alcohol, cetearyl nol, phenyl trimethicone, polysorbate 20, propylene glycol, octanoate, cethyl acetate, cetyl alcohol, cetyl dimethicone quaternium-15, quaternium-18 hectorite, retinyl palmitate, copolyol, cocoyl sarcosine, diazolidinyl urea, dicaprylate/ Sodium dehydroacetate, sodium hydrogenated tallow dicaprate, dioctyl adipate, dipropylene glycol, disodium glutamate, Sorbitan sesquioleate, Sorbitan trioleate, titanium EDTA, disopropyl dimer dilinoleate, ethylene brassylate, dioxide, tocopheryl acetate, triclosan, tridecyl trimellitate, ethylene/methacrylate copolymer, ethylene/vinyl acetate various coloring agents, various plant extracts, water, aloe copolymer, fragrance, glycerin, glyceryl Stearate, hexyl lau extract and allontoin. US 2007/0275021 A1 Nov. 29, 2007

0131 The present invention provides for novel formula EXAMPLE 4 tions of face powder products by incorporating bioactive glass into a combination of any of the above-listed ingredi Lipstick with Bioglass Formulas CPD3-33 A, B, C entS. 0137) 0132 Generally, lipstick and lip gloss products comprise castor oil, caprylic/capric triglycerides, Stearic acid, lanolin, polybutene, mineral oil, kanolin, silica, BHT, and coloring INGREDIENTS wt % A wt % B wt % C agents. Part A

0.133 Common formulations of lipstick and lip gloss Red 7 Ca Lake 3.0 3.0 3.0 products comprise trictyldodecyl citrate, isotridecyl Red 6 Ba Lake 1.O 1.O 1.O isononanoate, C10-20 cholesterol/lanosterol esters, syn Red 33 Al Lake 1.O 1.O 1.O thetic beeswax, paraffin, cetyl alcohol, candelilla wax, aloe Castor Oil 1S.O 1S.O 1S.O extract, retinyl palmitate, tocopheryl acetate, ascorbyl Part B palmitate, sodium hyaluronate, PEG-20 sorbitan beeswax, Castor Oil 30.6 30.6 30.6 quaternium-18 hectorite, benzoic acid, BHA, methylpara Carnauba Wax 2.0 2.0 2.0 Candellila Wax 7.0 7.0 7.0 ben, propylparaben, titanium dioxide, mica, iron dioxides Ozokerite Wax 2.0 2.0 2.0 and various coloring agents. Microcrystalline Wax 3.0 3.0 3.0 Jojoba Oil 2S.O 2S.O 2S.O 0134) Lipstick and lip gloss products may also include Vitamin E 1S.O 1S.O 1S.O Methyl Paraben O.1 O.1 O.1 one or more of the following: acetylated lanolin, acrylates Propyl Paraben O.2 O.2 O.2 copolymer, allantoin, ascorbyl palmitate, beeswax, bis-dig Schott Glass 45s5 (<4 ave. part. size) O.1 O.1 O.1 lyceryl polyacyladipate-2, bismuth oxychloride, butylpara Part C ben, C10-30 cholesterol/lanosterol esters, carnauba, castor Tac USP 1O.O oil, cethyl acetate, cetyl dimethicone copolyol, cetyl Bioglass 45 S (c) 1.6 L 1O.O octanoate, citric acid, cocoa butter, coconut oil, cyclomethi Bioglass 58s (a) 0.77. 1O.O cone, cyclopentasiloxane, cyclotetrasiloxane, diisopropyl. dimer dilinoleate, dimethicone, trissostearyl citrate, D1-to 1OO.O 1OO.O 1OO.O copherol, drometrizole, D-tocopherol, ethylcellulose, fra grance, glyceryl oleate, grapeseed oil, hexyl laurate, hydro genated polyisobutene, hydrogenated Soy glyceride, Observations: hydrogenated vegetable oil, hydrolyzed collagen, hydro 0.138 1) The Talc Formula did not set as well/quickly as lyzed glucosaminoglycans, isocetyl Stearate, isododecane, either glass. isopropyl myristate, isostearyl palmitate, lanolin, magne sium ascorbyl phosphate, menthol, methicone, methyl glu 0.139 2) The 58s glass formula set up somewhat faster cose sesquistearate, microcrystalline wax, mineral oil, myri and appeared to make a smoother product as compared to styl lactate, neopentyl glycol dicoctanoate, octyl the 45s glass formula. hydroxy Stearate, octyl methoxycinnamate, octyl palmitate, 0140. 3) The Talc formula showed more feathering octyldodecanol, oleyl alcohol, oxybenzone, oZokerite, padi (bleeding) at 1 hr. mate, PEG-20 sorbitan beeswax, pentaerythrity1 tetrabehen ate, pentaerythrityl tetraisostearate, petrolatum, phytosterol/ 0.141 Generally, lip treatment products comprise mois octyldodecyl lauroyl glutamate, polybutene, polyethelene, turizers, healants and protectants such as petrolatum jelly. polyethylene, polyglyceryl-2 diisoStearate, polyglyceryl-3 0.142 Common formulations of lip treatment products disoStearate, polyglyceryl-4 isostearate, polymethysilses comprise white petrolatum, ethylhexyl P-methoxycin quioxane, PPG 51/Smdi copolymer, propyl gallate, propy namate, carnuba, hydroxylated milk glycerides, nylon-12, lene glycol, PVP/hexadecene copolymer, seasame oil, shel paraffin, tocopheryl acetate, bisabolol, retinyl palmitate, lac wax, silica, Sodium hyaluronate, Sodium lactate, sodium panthenol, lecithin, Stearic, soya Stearol, Zinc sulfate, sodium PCA, sodium phosphate, Sodium saccharin, Sorbic acid, saccaharin, various natural and artificial flavorings and vari squalane, Stearic acid, Stearyl dimethicone, Sucrose acetate ous plant extracts. isobutyrate, T-butyl hydroquinone, tocopheryl acetate, tri 0.143 Lip treatment products may also include one or hydroxy Stearin, trisoStearyl citrate, trilsoStearin, trimethyl more of the following: 2-ethylhexyl salicylate, 2-octyldode siloxysilicate, urea, various natural and artificial flavorings, canol, allantoin, aloe extract, alum, arachadyl propionate, various vitamin agents, water, wheat germ oil, caprylic/ beeswax, benzoic acid, benzophenone-3, BHT, bisacodyl, capric triglyceride, ceresin, trifluoromethyl C1-4 alkyl dime borage seed oil, camphor, carnuba wax, castor oil, cetyl thicone, arachidyl propionate, phenyl trimethicon and BHT. alcohol, cetyl esters, cocoa butter, corn oil, dimethicone, 0135 The present invention provides for novel formula dimethicone, dipentaerythrityl hexacaprate/hexacaprylate, tions of lipstick and lipgloss products by incorporating fragrance, hydrogenated castor oil, isopropyllanolate, kukui bioactive glass, into a combination of any of the above-listed nut oil, lanolin, menthol, methylparaben, microcrystalline ingredients. wax, mineral oil, mixed wax, octadecene/ma copolymer, octyl methoxycinamate, octyl palmitate, oxybenzone, oZo 0136. Example 4 below provides an exemplary embodi kerite, padimate, paraffin, petrolatum, phenol, polybutene, ments of lipstick formulations incorporating bioactive glass. polyphenylmethylsiloxane 556, polythylene, propylparaben, US 2007/0275021 A1 Nov. 29, 2007 purified water, saccharin, salicylic acid, SD alcohol 36, silica, silver, styrenefacrylates copolymer, Sucrose acetate Stearyl alcohol, Sunflower seed oil, talc, tridecyl Stearate, isobutyrate, Styrenefacrylates/acrylonitrile copolymer, tet tridecyl trimellitate, triisoStearin esters, various coloring rabutyl phenyl hydroxybenzoate, titanium dioxide, toco agents, wax paraffin and white wax. pheryl acetate, tosylamide? epoxy resin, tosylamide/formal 0144. The present invention provides for novel formula dehyde resin, tribenzoin, trimelitic anhydride, ultramarines, tions of lip treatment products by incorporating bioactive various coloring agents, Stearalkonium hectorite, dimethi glass into a combination of any of the above-listed ingredi cone copolyol, acrylate copolymer, dipropylene glycol entS. dibenzoate, tribenzoin, biotin, panthenol, retinyl palmitate, 0145 Generally, lipliner products comprise a wax prod tocopheryl acetate, aluminum powder, bismuth oxychloride, uct, a preservative, mineral oil, Stearic acid and coloring polyester resin, Sucrose acetate isobutyrate, diacetone alco agents. hol, benzophenone-1, guanine, toluene, tosylamide/formal dehyde resin, dibutyl phthalate, tetrabutyl phenyl hydroxy 0146 Common formulations of lipliner products com prise castor oil, isopropyl palmitate, lanolin, beeswax, can benzoate, titanium dioxide, iron dioxides, mica, ferric delilla wax, meadowfoam seed oil, fragrance, Sesame oil, ammonium ferrocyamide, calcium pantothenate, heptane, polybutene, ozokerite, dioctyldodecyl fluoroheptyl citrate, etocrylene, acetyl tributy citrate, hydrolyzed keratin and carnuba wax, paraffin, hydrogenated Soy glyceride, propy various coloring agents. lene glycol, Stearic acid, Sodium saccharin, propylparaben, 0152 The present invention provides for novel formula propyl gallate and citric acid. tions of nail polish products by incorporating bioactive glass 0147 Lipliner products may also include one or more of into a combination of any of the above-listed ingredients. the following: aloe extract, BHA, bismuth oxychloride, bronze powder, butylparaben, carmine, castor oil, ceresin, 0153. Bioactive glass and sol-gel derived bioactive glass copper powder, cyclomethicone, disoStearyl dimer dili reacts with aqueous fluids to form a solution that is rich in noleate, hydrated silica, hydrogenated castor oil, hydroge inorganic elements, such as calcium, phosphorous, sodium nated cottonseed oil, hydrogenated vegetable oil, iron and silicon. These inorganic elements can precipitate on oxides, manganese violet methylparaben, mica, PEG-6 bees nails to form a mineralogical layer (i.e., hydroxyapatite). wax, polybutene, quaternium-18 bentonite, retinyl palmi This mineralogical layer is expected to add strength to nails. tate, sodium saccharin, synthetic wax, titanium dioxide, tocopheryl acetate, various coloring agents, various natural 0154) Examples 5-8 below provide exemplary embodi and artificial flavorings, Zinc oxide, asorbyl palmitate, Satu ments of nail care formulations incorporating bioactive rated fatty acid glycerides, caprylic/capric acid triglycerides, glass, including sol-gel-derived bioactive glass. glyceryl tripalmitate, parahydroxybenzoate ester, soybean phospholipid, soybean lecithin and lipophilic glyceryl EXAMPLE 5 monoStearate. 0148. The present invention provides for novel formula Composition of Anhydrous Nail-Strengthening Gel tions of lip liner products by incorporating bioactive glass I into a combination of any of the above-listed ingredients. O155) 0149 Generally, nail polish products comprise nitrocel lulose, a lacquer dissolved in Solvents such as acetone or ethyl alcohol and coloring agents. INGREDIENTS wt % 0150 Common formulations of nail polish products com Jojoba Glaze 80.0 prise ethyl acetate, butyl acetate, isopropyl alcohol, nitro Schott Glass Bioactive Glass (<4 ave. part. size) 2O.O cellulose, glyceryl tribenzoate, acetyl tributyl citrate, Stear alkonium bentonite, Stearalkonium hectorite, glyceryl 1OO.O triacetate, camphor, SD alcohol 40, citric acid, malic acid, phosphoric acid, 2,4-di-t-butylphenyl-3,5-di-t-butyl-4 hydroxyben and tin oxide. EXAMPLE 6 0151. Nail polish products may also include one or more of the following: acrylates copolymer, algae extract, alumi Composition of Anhydrous Nail-Strengthening Gel num, amyul acetate, benzophenone-1, biotin, bismuth oxy II chloride, chromium hydroxide green, chromium oxide greens, diacetone alcohol, dibutyl phthalate, dimethicone 0156) copolyol, dipropylene glycol dibenzoate, ethyl tosylamide, etocrylene, ferric ammonium ferrocyamide, ferric ferrocya mide, fiberglass, fragrance, glycols copolymer, guanine, hydrated silica, iron oxides, isobutyl acetate, manganese INGREDIENTS wt % violet, methyl acetate, mica, N-butyl alcohol, oxidized poly Jojoba Glaze 90.0 ethylene, panthenol, phthalic anhydride, phthalic anhydride/ Schott Glass Bioactive Glass (<4 ave. part. size) 1O.O glycerin/glycidyl decandate cop, phthalic anhydride/trimel litic anhydride/glycols copolymer, polyester resin, polyethylene terephithlate, propyl acetate, retinyl palmitate, US 2007/0275021 A1 Nov. 29, 2007 16

EXAMPLE 7 0166 Generally, maxipad and pantiliner products com prise cellulose, plastic and adhesive strips. Maxipad and Composition of Nail Gel pantiliner products may also include a fragrance. Anhydrous with Bioactive Glass 0.167 The present invention provides for novel formula tions of tampon, maxipad and pantiliner products by incor O157) porating bioactive glass into a combination of any of the above-listed ingredients. 0.168. The antimicrobial and hygroscopic effects of bio INGREDIENTS wt % active glass are particularly useful in tampon, maxipad, and Glycerin 90.50 pantiliner products to reduce bacteria and odor. Pemulen (R TR-2 O.45 Acne Prevention and Treatment Products Schott Glass Bioactive (<41 ave. part. size) 9. OS 0169. The present invention includes novel formulations 100.00 which incorporate bioactive glass into various brands of acne prevention and treatment products such as the products marketed under the brand names Acne Aid, Aconmel, EXAMPLE 8 Aveeno, Biore, Burt’s Bees, Clean & Clear, Clear Logix, Clearasil, Desert Essence, Exact, Fostex, Garden Botanika, Composition of Skin and Nail Treatment Hyland's Homeopathic, Tonax, Jason, Johnson & Johnson, Kiss My Face, Liquimat, Neutrogena, Noxzema, Orange Anhydrous with Sol-Gel-Derived Bioactive Glass Daily, Oxy, Pamoxyl, Pernox, Ponds, Rezamid, Sal Ac, 0158 Salicylic Acid, Sastid, Sebasorb, Stiefel, Stridex, Suave, Sulforcin, Sulfur Soap, Sulpho-Lac, T-Zone, Zirh, and prod ucts produced by high-end and generic manufacturers. 0170 Generally, acne prevention and treatment products INGREDIENTS wt % comprise the active ingredient benzoyl peroxide or salicylic Jojoba Glaze 91.5 acid. Brown Iron Oxide O.S Titanium Dioxide O.S 0171 Common formulations of acne prevention and Tac - USP 2.5 treatment products comprise active ingredients consisting of Schott Glass sol-gel-derived bioactive glass S.O a combination of resorcinol, sulfur and alcohol or benzoyl peroxide. 0172 Acne prevention and treatment products may also include one or more of the following inactive ingredients: 0159 Generally, nail polish remover products comprise alcohol, attapulgite, bentonite, butylparaben, carbomer, cit acetone or ethyl acetate. ric acid, dioctyl sodium sulfosuccinate, disodium EDTA, 0160 Common formulations of nail polish remover prod edetate disodium, EDTA, fragrance, glycerin, hydroxyeth ucts comprise ethyl acetate, alcohol, water, propylene car ylcellulose, hydroxypropyl methylcellulose, iron oxides, bonate, dimethyl glutarate, dimethyl Succinate, dimethyl isopropyl myristate, kaolin, lauramide dea, methylparaben, adipate, gelatin, glycerin, diglycerol, fragrance, isopropanol, parachlorometaxylenol, PEG-8 laurate, potassium hydrox propyl acetate, benzophenone-1, castor oil and various col ide, propylene glycol, propylparaben, Salicylic acid, sim oring agents. ethicone, sodium bisulfite, sodium borohydride, sodium chloride, sodium cocoate, sodium hydroxide, Sodium 0161 Nail polish remover products may also include one polynapthalene Sulfonate, sodium tallowate, talc, titanium or more of the following: acetone, citric acid, denatonium dioxide, trisodium hedta, various plant and mineral extracts, benzoate, PEG-75 lanolin oil, mineral oil, panthenol and water, Xanthan gum, Zinc oxide, aluminum hydroxide, glyc tocopheryl acetate. eryl stearate SE and PEG-12. 0162 Bioactive glass may be incorporated into a com 0173 The present invention provides for novel formula bination of any of the above-listed ingredients. tions of acne prevention and treatment products by incor Tampon, Maxipad and Pantiliner Products porating bioactive glass into a combination of any of the above-listed ingredients. 0163 The present invention includes novel formulations which incorporate bioactive glass into various brands of 0.174 The antimicrobial and anti-inflammatory proper tampon, maxipad and pantiliner products such as the prod ties of bioactive glass are particularly useful in acne pre ucts marketed under the brand names Always, Carefree, vention and treatment products. Bioactive glass can be used Kotex, o.b., Playtex, Tampax, and products produced by in topical acne creams to reduce inflammation, while also high-end and generic manufacturers. killing the bacteria and micro-organisms that cause acne. 0164 Generally, tampon products comprise cotton and/or Facial Cleansing, Toning, Exfoliating and Makeup Removal rayon overwrap and cotton cord. Products 0165 Tampon products may also include one or more of 0.175. The present invention includes novel formulations the following: polyethylene/polyester cover, polysorbate-20, which incorporate bioactive glass into various brands of fragrance, and a plastic or cardboard applicator. facial cleansing, toning, exfoliating products and makeup US 2007/0275021 A1 Nov. 29, 2007 removal products such as the products marketed under the phosphate, phenoxyethanol, phenylethyl alcohol, poloxamer brand names Aapri, Albolene, Almay, Alpha Hydrox, Ambi, 184, polydecene, polyol alkoxy esters, polyoxyethylene 15 Aqua Glycolic, Aquanil Lotion, Artra, Aveeno, Basis, Biore, cocoamine phosphatefoleate comp, polyduaternium-10, Bodycology, Bonnie Bell, Brite-Life, Burts's Bees, polyduaternium-24, polyduaternium-7 capryloyl salicylic Camocare, Cetaphil, Clean & Clear, Clairol, Clearasil, acid, polysorbate 20, polysorbate 60, polysorbate 80, potas Clearly Natural, Cover Girl, Curad, Dickinson's, DML. sium hydroxide, potassium myristate, potassium palmitate, Earth Science, Freeman, Garden Botanika, Tonax, Jason, potassium sorbate, potassium stearate, PPG-10 butanediol, Jergens, Johnson & Johnson, Keri, Kiss My Face, La Bella, PPG-10 methyl glucose ether, PPG-12 buteth-16, PPG-15 L'Oreal, Maybelline, Moisturel, Neutrogena, Nivea, Stearyl ether, propylene glycol, propylparaben, quaternium Noxzema, Oil of Olay, Oxy, Phisoderm, Plenitude, Ponds, 15, Safflower oil, salicylic acid, sesame oil, simethicone, Propa pH, Purpose, Reviva, Revlon, RoC, Sea Breeze, sodium borate, sodium C12-15 alcohol ethoxycarboxylate, Seban, St. Ives Swiss Formula, Stiefel, Stridex, Suave, Sodium chloride, Sodium cocoate, Sodium cocoylglutamate, T-Zone, Ten-O-Six, Vegee Tonic, and products produced Sodium cocoyl isethionate, Sodium cocoyl isethionate, by high-end and generic manufacturers. Sodium dodecylbenzenesulfonate, Sodium isethionate, Sodium isostearoyl lactylate, Sodium lactate, sodium lauro 0176 Generally, facial cleansing, toning, or exfoliating amphoacetate, Sodium lauroyl sarcosinate, Sodium lauryl products or makeup removal products comprise camphor, Sulfate, Sodium lauryl Sulfoacetate, Sodium myristoyl sarco water, menthol, Stearic acid, calcium hydroxide, ammonium sinate, Sodium palm kernelate, Sodium PCA, sodium Stear hydroxide and an exfoliant Such as alpha or beta hydroxy ate, sodium sulfite, sodium tallowate, sodium trideceth Sul acid, retinoic acid, azelaic acid or adapelene. fate, Sodium cocoyl isethionate, Stearamidopropyl 0177 Common formulations of facial cleansing, toning, pg-dimonium chloride phosphate, Steareth-2, Steareth-21, exfoliating products and makeup removal products comprise Stearic acid, Stearyl alcohol. Sucrose laurate, talc, tea-stear water, glycerin, Sodium laureth Sulfate, cocamidopropyl ate, tetrasodium EDTA, tetrasodium etibronate, titanium betaine, tocopheryl acetate, panthenol, methyl lactate, cary dioxide, triclocarban, pentasodium pentetate, triclosan, tri lates/steareth-20, methacrylate copolymer, Xanthan gum, ethanolamine, trisodium hedta, tromethamine, Sodium cetyl microcrystalline wax, sodium magnesium, silicate, sodium Sulfate, oleyl betaine, laureth-3, Self-emulsifying wax, coco hydroxide, fragrance, DMDM hydantoin, iodopropynlbutyl amphocarboxyglycinate, lauramide DEA, lauramide MEA, carbamate, various vitamin, mineral, fruit and vegetable linoleamide DEA, polyethylene, lauryl methyl gluceth-10 extracts and various coloring agents. dihydroxypropyldimonium chloride, Sodium lauroamphodi 0.178 Facial cleansing, toning, and exfoliating products acetate and decy glucoside. and makeup removal products may also include one or more 0.179 The present invention provides for novel formula of the following: 1-hexadecanol, iodopropyl butylcarbam tions of facial cleansing, toning, and exfoliating products ate, acrylate crosspolymer, acrylates/C10-30 alkyl, allan and makeup removal products by incorporating bioactive toin, ammonium hydroxide, beeswax, benzophenone-4, ben glass into a combination of any of the above-listed ingredi Zyl alcohol, beta carotene, BHT, boric acid, butylene glycol, entS. butylparaben, camphor, caprylic?capric triglyceride, car bomer, ceresin, ceteareth-20, cetearyl alcohol, cetearyl 0180. The anti-inflammatory and antimicrobial effects of isononanoate, cetyl alcohol, cetyl hydroxyethylcellulose, bioactive glass are particularly useful in facial cleansing, cetyl octanoate, chlorhexidrine digluconate, chromium toning, and exfoliating products and makeup removal prod hydroxide green, citric acid, cocamide mea, cocamidopropyl ucts to reduce bacteria and inflammation. Additionally, the phosphatidyl pg-dimonium chloride, cocamidopropylamine abrasive quality of bioactive glass is useful in exfoliation. oxide, colloidal oatmeal, corn germ oil, dea-cetyl phosphate, Facial Moisturizing Anti-Wrinkle, Eye Treatment and Hand diazolidinyl urea, dicaprylate/dicaprate, dimethicone, diso and Body Lotion Products dium EDTA, disodium laureth Sulfosuccinate, disodium lauroamphodiacetate, disodium oleamido PEG-2 sulfosuc 0181. The present invention includes novel formulations cinate, disodium ricinoleamido mea-sulfo Succinate, edetate which incorporate bioactive glass into various brands of disodium, EDTA, ethoxydiglycol, ethylparaben, gelatin, facial moisturizing, anti-wrinkle, anti-aging, eye treatment glyceryl laurate, glyceryl polymethacrylate, glyceryl Stear and hand and body lotion products such as the products ate, glycol DS, hexylene glycol, hydroxycetyl hydroxyethyl marketed under the brand names Acid Mantle, A-Derma, dimonium chloride, hydroxypropyl guar hydroxypropyltri Abra, Alba Botanica, Albolene, Almay, Ala Derm, Aller monium chloride, hydroxypropylcellulose, imidazolidinyl creme, Aloe Vera 80, Alpha Hydrox, Alpha Keri, AmLactin, urea, iron oxides, isocetyl alcohol, isopropyl myristate, Aqua Care, Aqua Glycolic, Aqua Lactin, Aquanil, ASorbase, isopropyl palmitate, lactic acid, lanolin oil, laureth-4, lau ArthiCare, Atrac-Tran, Aveeno, Avon, Baby Magic, Baker reth-9, lauric acid, lauryl phosphate, lauryl polyglucose, Cummins, Balm Barr, Basis, Beauty Without Crvetty, Beta magnesium aluminum silicate, menthol, methyl gluceth 20, Care, Biore, Bodycology, Brite-Life, Burt’s Bees, Calgon, methylchloroisothiazolinone, methyldibromo glutaronitirle, Camocare Gold, Ca-Rezz, Carmol, Carrington, CBI, methylisothiazolinone, methylparaben, mineral oil, myristic Cetaphil, Chamberlain, Clairol, Clean & Clear, Complex 15, acid, octyl hydroxyStearate, olive oil, palmitic acid, paraffin, Coral Springs, Corn Huskers, Curel, Cutar, Cutemol, Der PEG-10 hydrogenated castor oil, PEG-10 soya sterol, PEG mal Therapy, Dermacerin, Dermasil, Dermatone, Dermo 100 stearate, PEG-120 glucose dioleate, PEG-120 methyl van, DiaDermal, Diabetierm, Dixie Health, DML, Doak, glucose dioleate, PEG-150 distearate, PEG-2 stearate, PEG DPM, Earthly Elements, Earth Science, Earth Therapeutics, 20, PEG-200 glyceryl tallowate, PEG-3 distearate, PEG-7 Elta, Epilyt, Esoterica, Estar, Eucerin, Evian, Exorex, Face glyceryl cocoate, PEG-8, PEG-80 sorbitan laurate, PEG-9 Lift, Formula 405, Fougera, Freeman, Fruit of the Earth, tridecyl ether, pentasodium penetate, petrolatum, PG-acetate Galderma, Garden Botanika, Gold Bond, Golden Sun, Good US 2007/0275021 A1 Nov. 29, 2007

Sense, Healthflow, Hydroxy-C, Jamieson & Co., J.C. Bril acetate, cetyl dimethicone, cetyl esters, cetyl octanoate, cetyl lantine, Jason, Jean Nate, Jergens, Jockey Club, KC & palmitate, cetyl ricinoleate, chloride, chlorphenesin, chole Company, Keri, Kerodex 51, Kiss My Face, La Bella, calciferol, cholesteryl isostearate, choleth-24, citric acid, Lac-Hydrin Five, LactiCare, Lady Esther, Lander, Lanolar, coco caprylate caprate, cocoa butter, cocobetaine, colloidal Lantiseptic, Little Forest, Lubrex, Lubriderm, MG-217, oatmeal, copolymer, cyclomethicone, cyclopentasiloxane, Moisturel, Nate Naturals, Naturade, Naturalife, Nature's dea-cetyl phosphate, dea-oleth-3 phosphate, dermasterone Apothecary, Natures Family, Nature's Gate, Neutrogena, (bioactive multi wild yam species complex), diazolidinyl Nivea, Noxzema, Nutraderm, Nutra-E, Nutraderm, Nutra urea, dicaprylate/dicaprate, dicaprylyl ether, dicaprylyl plu, Oilatum Ad, Oil of Olay, Optimum Series, Orange maleate, diisopropyl sebacate, dioctanoate, dioctyl Succi Daily, Pacquin, Palmer's, Pen-Kera, Perfect Solutions, Petal nate, dipropylene glycol, distearly dimonium chloride, dis Fresh, Plenitude, Ponds, Porcelana, Prax, Pretty Feet & tearyldimonium, emulsifiers, ethoxydiglycol, ethylene bras Hands, Proteque, Purpose, Queen Helene, Revlon, Rex Eme, Sylate, ethylhexyl P-methoxycinnamate, glycerin, RoC, Rose Milk, Sarah Michaels, Sarna, Sea Breeze, SFC, eucalyptol, eucalyptus oil, fumaric acid, gelatin, glucose, Seba Nil. Shepard's, Shikai, Simply Be Well, Soft Sense, glyceryl dilaurate, glycolic acid, glycoproteins, glysine, State of Mind, St. Ives Swiss Formula, Stik, Stretch Mark, GMS/PEG 100 stearate, guar gum, hexyl laurate, hyaluronic Suave, Sudden Change, Sundance, Sween, The Healing acid, hydrogenated castor oil, hydrogenated lanolin, hydro Garden, Theraplex, Triple Lanolin, University Medical, genated polyisobutane, hydrolyzed animal protein, hydroxy U-Lactin, Ultra Mide 25, Vanicream, Vaseline, Vas Pet, Vital ethylcellulose, imidazolidinyl urea, isocetyl Stearate, isode Care, Vitec, Wibi, Wild Yam Complex, Woltra, Xpressions, cyl oleate, isohexadecane, isopropyl isostearate, isopropyl Yardley's of London, Zim’s Crack Creme, and products myristate, isopropyl palmitate, isostearic acid, isostearyl produced by high-end and generic manufacturers. alcohol, isostearylbenzoate, isotearyl neopentandate, kaolin 0182 Bioactive glass is particularly useful in these prod (natural clay), lactic acid, lanolin, diazolidinyl urea, laureth ucts since it possesses anti-inflammatory and antimicrobial 23, laureth-4, laureth-7, lauroyl lysine, linoleamidopropyl properties. The mild abrasive and high pH in certain for pg-dimonium chloride phosphate, linseed oil, magnesium mulations generate an exfoliant effect on the skin to remove ascorbyl phosphate, magnesium Sulfate, malic acid, men wrinkles. In addition, these formulations which incorporate thol, menthyl anthranilate, menthyl lactate, methoxypropy bioactive glass may be used to hide shadows created by lgluconamide, methyl gluceth-20, methylcellulose, methyl wrinkles. chloroisothiazolinone, methylisothiazol, methylisothiazolinone, mineral oil, mink oil, monoglyceride 0183 Skin formulations comprising bioactive glass also citrate, myristyl lactate, myristyl myristate, neopentylglycol provide a protective HCA layer on the corneal layer of the dicaprylate/dicaprate, nylon-12, octyl hydroxy Stearate, octyl skin. In addition, the anti-inflammatory action of bioactive methoxycinamate, PEG-8 beeswax, phenylbenzimidazole glass reduces redness and irritation while the anti-microbial Sulfonic acid, octyl methoxycinnamate, octyl palmitate, action disinfects. octyl salicylate, octyldodecanol, octyldodecyl myristate, 0184 Generally, facial moisturizing, anti-wrinkle, and octyldodecyl neopentanotate, oleyl sarcosin, oxybenzone, eye care products or hand and body lotion products comprise palm oil, palmitic acid, PEG 100 stearate, PEG-10 soya an emollient, a preservative and collagen. sterol, PEG-100 stearate, PEG-15 cocamine, PEG-4 dilau rate, PEG-40 stearate, PEG-5 glyceryl stearate, PEG-50 0185. Common formulations of facial moisturizing, anti stearate, PEG-8 distearate, PEG-8 stearate, petrolatum, PG wrinkle, and eye care products and hand and body lotion dioctanoate, phenol, phenoxyethanol, phenylcarbinol, phe products comprise water, glycerin, Stearic acid, aloe gel. nyldimethicone, phospholipids, polyacrylamide, polyglyc glycol Stearate, soya sterol, lecithin, dimethicone, glyceryl eryl-3 methylglucose distearate, polyglyceryl-4 isostearate, Stearate, cetyl alcohol, magnesium aluminum silicate, fra polyglycerylmethacrylate, polyoxyl 40 stearate, polysorbate grance, carbomer, stearamide AMP methylparaben, DMDM 20, polysorbate 40, polysorbate 60, potassium hydroxide, hydantoin, iodopropynl, butycarbamate, disodium EDTA, potassium Sorbate, potassium Stearate, progesterone USP butylene glycol, titanium dioxide, various mineral, fruit, propylene glycol, PVM/MA decadiene crosspolymer, PVP/ vegetable, and vitamin extracts and various coloring agents. eicosene copolymer, PVP/hexadecene copolymer, pyridox 0186 Facial moisturizing, anti-wrinkle, and eye care ine HCL (vitamin B6), quaternium-15, resorcinol, retinyl products and hand and body lotion products may also palmitate, saccharide isomerate, Salicylic acid, SD alcohol include one or more of the following: 1-hexadecanol, ace 40-b, shea butter, silk amino acid, sodium benzoate, Sodium mannan hydrogel, acetylated lanolin alcohol, acrylates borate, Sodium calcium alginate, Sodium carbomer, sodium copolymer, acrylates/C10-30 alkyl acrylate crosspolymer, chloride, Sodium DNA, sodium hyaluronate, sodium isos acrylates/carbamate copolymer, alantoin octyl dimenthyl tearoyl lactylate, sodium lauryl sulfate, sodium PCA, paba, alcohol, allantointetra EDTA, alpha lipoic acid, alu Sodium pyruvate, Sodium Stearate, Sorbic acid, Sorbitan minum starch octenylsuccinate, ammonium glycolate, laurate, Sorbitan Stearate, Sorbitol, Soybean oil, special pet ammonium hydroxide, ammonium lactate, apricot kernel rolatum fraction, squalane, steapyrium chloride, Stearamide oil, ascorbic acid polypeptide (vitamin c), ascorbyl palmi dea, Stearamidopropyl PG-dimonium chloride phosphate, tate, avobenzone, beeswax, benzophenone-4, benzyl alco Steareth-2, Steareth-21, Stearoxytrimethylsilane, Stearyl alco hol, BHT, bisaboloi, blyceryl Stearate, boric acid, butyro hol, tea, tea-acrylates/c10-30 alkyl acrylate crosspolymer, lactone, C10-30 cholesterol/lanosterol esters, C12-15 alkyl tea-carbomer 941, TEA-stearate, tetrasodium EDTA, trans benzoate, C13-14 isoparaffin, calcium chloride, calcium vector-delivery system (lipo copolymer complex), tricitrate, hydroxide, calcium sulfate, camphor, caprylic acid, castor tricaprin, tridecyl stearate, tridecyl trimellitate, triethanola oil, ceramide 3, ceresin, ceteareth 20, cetearyl alcohol, mine, triisocetyl citrate, trilaurin, trisodium EDTA, trola cetearyl octanoate, ceteth-24, cetrimonium chloride, cetyl mine, urea, wool wax, alcohol, collagen, elastin, propylpa US 2007/0275021 A1 Nov. 29, 2007

raben, PEG-40, sodium cetearyl sulfate, stearyl alcohol, quaterinium-22, Sodium hydroxide and silica. -continued

0187. The present invention provides for novel formula INGREDIENTS wt % A wt % B wt % C tions of facial moisturizing, anti-wrinkle, and eye care products and hand and body lotion products by incorporat Part E. ing bioactive glass into a combination of any of the above listed ingredients. Germaben II 1.O 1.O 1.O 0188 Examples 9 and 10 below provide exemplary 1OO.O 1OOO 1OO.O embodiments of skin lotion/makeup base and cream foun dation makeup formulations incorporating bioactive glass, 0191) Observations: Both 34 B and 34 Chave more even including Sol-gel-derived bioactive glass. application than 34 A (the talc formulation) and both feel much less oily than 34A after drying. 34C is less oily than EXAMPLE 9 34 B. Composition of Skin Lotion/Makeup Base with Foot Care Products Sol-Gel-Derived Bioactive Glass 0.192 The present invention includes novel formulations 0189) which incorporate bioactive glass into various brands of foot care products including products directed to treating ath lete's foot, fungal conditions and odor, as well as foot pumice products such as the products marketed under the INGREDIENTS wt % brand names Absorbine Jr., Aftate. Aloe Vesta, Alpha Mineral Oil (70ssu) 2O.O Hydrox, BFI, Baza, Blis-to-Sol, Brite-Life, Carrington, Polawax (R) S.O Cruex, Desenex, Desert Essence, Dr. Scholls, Earth Thera Glycerin 2.0 Deionized Water 65.4 peutics, Fougera, Freeman, Fungi Care, Fungiclear, Fungi Jaguar C-14S O.S Cure, Funginail, Fungi Nail, Fungus Stop, Gold Bond, Phenobact 1.O Health at Home, Johnson's, LA Cross, Lamisil, Lotrimin, Fragrance (High End Botanicals AFF #ACR2492019E) O.1 Mavis, Micatin, Miconazole, Neutrogena, NP-27, Odor Citric Acid monohydrate powder 2.0 Eaters, Orly, Outgrow, Parex, Pinaud, Podiacin, Pretty Feet Schott Glass sol-gel-derived bioactive glass 4.0 & Hands, Quinsana, St. Ives Swiss Formula, Sween, Tet 1OOO terine, Tinactin, Ting, TingAF, Trim, Triple Care, Vaseline, Zeasorb, and products produced by high-end and generic manufacturers. EXAMPLE 10 0193 Foot care formulations comprising bioactive glass are anti-microbial and create a soothing effect. The anti Cream Foundation Makeup with Bioglass Formulas microbial effect of bioactive glass includes antifugal prop CPD3-34 A, B, C erties making bioactive glass particularly well-suited for 0190. foot care products. In addition, the hygroscopic properties of bioactive glass help to reduce foot moisture. Bioactive glass also can be used to create or be incorporated into a foot pumice. For example, powders may be sintered by any INGREDIENTS wt % A wt % B wt % C acceptable method to form a porous solid material for use in Part A a foot pumice.

Crodafos CES 3.0 3.0 3.0 0194 Generally, foot care products comprise the active Volpo 10 O.8 O.8 O.8 ingredient allylamine, azole, griseofulvin, oxiconazole or Volpo 3 O.6 O6 O.6 tolnaftate. Jojoba Oil 1O.O 1O.O 1O.O Cyclomethicone D5 S.O S.O S.O 0.195 Common formulations of foot care products com Part B prise active ingredients consisting of a combination of Deionized Water 59.9 59.9 59.9 tolnaftate, Zinc undecylenate, miconazole, nitrate, corn NaOH O.1 O.1 O.1 starch, Zinc oxide, kaolin and benzethonium chloride. Volpo 10 O.1 O.1 O.1 TiO2 7.0 7.0 7.0 0.196 Foot care products may also include one or more of Yellow Iron Oxide O.8 O.8 O.8 the following inactive ingredients: acetone, acrylate copoly Red Iron Oxide O.3 O.3 O.3 mer, aldioxa, behenoxy dimethicone, calendula, carbohy 50:50 Black Brown Iron Oxide Blend O.1 O.1 O.1 drate acrylic copolymer, ceteareth-6, chloroxylenol, diaZo Part C lidinyl urea, edetate disodium, fragrance, imidurea, iodine, Propylene Glycol 3.0 3.0 3.0 isobutane, isopropyl myristate, menthol, microporous cellu Jaguar 13S O.3 O.3 O.3 lose, monobasic sodium phosphate, Stearamidoethyl diethy Part D lamine, myristyl myristate, polysorbate 60, polysorbate 80, Tac USP 8.0 potassium iodide, quaternium, SD alcohol 40, Sodium bicar Bioglass 45 S (c) 1.6 L 8.0 bonate, Stearalkonium hectorite, Stearamidoethyl diethy Bioglass 58s (a) 0.77. 8.0 lamine, Stearic acid, Stearyl alcohol, talc, thymol, triglyceryl disoStearate, wormwood oil, Xanthan gum, water, salicylic US 2007/0275021 A1 Nov. 29, 2007 20 acid, methyl salicylate, bentonite, camphor, benzethonium white petrolatum, white wax, Zinc oxide, Zinc pyrithione, chloride, terbinafine hydrochloride, benzyl alcohol, cetyl paraffin, yellow wax, maltodextrin, and various fruit, veg alcohol, cetyl palmitate, sodium hydroxide, Sorbitan etable, mineral and vitamin extracts. monostearate, starch, magnesium Stearate and various 0202 The present invention provides for novel formula herbal, plant and mineral extracts. tions of anti-itch products by incorporating bioactive glass 0197) The present invention provides for novel formula into a combination of any of the above-listed ingredients. tions of foot care products by incorporating bioactive glass Antibacterial, Antiseptic, Antibiotic and First Aid Products into a combination of any of the above-listed ingredients. 0203 The present invention includes novel formulations Anti-Itch Products which incorporate bioactive glass into various brands of antibacterial, antiseptic, antibiotic and first aid products Such 0198 The present invention includes novel formulations as the products marketed under the brand names Absorbine, which incorporate bioactive glass into various brands of B-D, Baciguent, Bactine, Bag Balm, Ben Gay, Betadine, anti-itch products such as the products marketed under the Betasept, BFI, Blue Star, Boil Ease, Brite-Life, Campho brand names A&D Ointment, After Bite, Americaine, Aqua Phenique, CarraklenZ, Clinipad, Clocream, Dermoplast, phor, Arctic Spray, Aveeno, Baciguent, Bactine, Benadryl, Dyna-hex, Family Medic, Flex-All, Fougera, Glovers, Gold Betadine, Blue Star, Boil Ease, Caladryl, Caldecort, Cam Bond, Good Sense, Hibiclens, Hibistat, Humco, Todex, pho-Phenique, Chiggerex, Cortaid, Cortizone, Dermarest, Johnson & Johnson, Lanabiotic, Lanacort, Lander, Lano Dermoplast, Exorex, Foille, Gold Bond, Good Sense, cane, Lavocal, Medi-Quik, Mentholatum, Mineral Ice, Humco, Itch-X, Ivarest, Ivy Block, Ivy-Dry, KeriCort-10, Myciguent, Mycitracin, Neosporin, Nexcare, Polysporin, Lanabiotic, Lanacane, Lanacort, Lotrimin, Medi-Quik, Resinol, Sayman, Sensogard, Spectrocin, Sportscreme, Sto Micatin, Mycitracin, Neosporin, Nupercainal, Polysporin, pain, Swan, Top Care, Unguentine, Vicks, Zephiran Chlo Rhuli, Samol-HC, Solarcaine, Sting Kill, Tecnu, Tegrin, ride, and products produced by high-end and generic manu Tinactin, Unguentine, and products produced by high-end facturers. and generic manufacturers. 0204 Generally, antibacterial, antiseptic, antibiotic and 0199 Generally, anti-itch products comprise the active first aid products comprise alcohol, hydrogen peroxide, ingredient benzocaine, novacaine or bacitracin. povo-iodine, phenol or resorcinol. 0205 Common formulations of antibacterial, antiseptic, 0200 Common formulations of anti-itch products com antibiotic, and first aid products comprise active ingredients prise active ingredients consisting of a combination of consisting of a combination of polymyxin B Sulfate, baci camphor, benzocaine, pramoxine hydrochloride, Zinc tracin Zinc, neomycin and pramoxine hydrochloride. acetate or hydrocortisone. 0206 Antibacterial, antiseptic, antibiotic, and first aid 0201 Anti-itch products may also include one or more of products may also include one or more of the following the following inactive ingredients: 1-hexadecanol, 5-chloro inactive ingredients: bacitracin, benzalkonium chloride, 2-methyl-4-isothiazolin-3-one (and) 2-met, acetic acid, benzoic acid, bismuth-formiciodide, butylparaben, camphor, adhesives, alcohol, aloe Vera, aluminum Sulfate, ammonia, cholesterolized ointment, citric acid, base, dibasic sodium benzalkonium chloride, benzyl alcohol, bisabolol, butylene phosphate, edetate disodium, emulsifying wax, isopropyl glycol, calamine, calcium acetate, carbomer, ceresin, cet alcohol, licocaine hydrochloride, glycerin, hydrogen peroX eareth-20, cetearyl alcohol, ceteth-2, cetyl alcohol, cetyl ide, imidurea, isopropyl alcohol, light mineral oil, magne palmitate, chlorothymol, citric acid, coal tar Solution, dia sium carbonate, menthol, methylparaben, microcrystalline Zolidinyl urea, dimethicone, dioctyl sodium SulfoSuccinate, wax, octoxynol-9, petrolatum, phosphoric acid, poloxamer diphenhydramine HCl, disodium EDTA, distearlydimonium 188, polymyxin B Sulfate, potassium Sorate, pramoxine chloride, edetate disodium, ethoxydiglycol, fragrance, glyc HC1, propylene glycol, silica, Sodium benzoate, Sodium erin, glyceryl Stearate SE, glyceryl tribehenate, hydroxypro lauryl Sulfate, Sodium matabisulfite, thymoli, tocopheryl pyl methylcellulose, hydroxypropylcellulose, iodopropyl acetate, water, white petrolatum and Zinc phenol Sulfenate. butylcarbamate, isobutane (propellant), isopropanol, isopro 0207. The present invention provides for novel formula pyl alcohol, isopropyl myristate, isopropyl palmitate, isos tions of antibacterial, antiseptic, antibiotic, and first aid tearyl neopentanoate, karaya, laneth-16, lanolin, laureth-23, products by incorporating bioactive glass into a combination lidocaine hydrochloride, maltodextrin, menthol, menthol, of any of the above-listed ingredients. isopropyl alcohol, methyl gluceth-20, methyl salicylate, methylparaben, mineral oil, oatmeal flour, octoxynol-9, 0208 Formulations of particulate bioactive glass yield a olive oil, panthenol, PEG-2 oleate, petrolatum, polyethylene composition which is capable of dramatically reducing the glycol, polysorbate 40, potassium hydroxide, potato dextrin, amount of time necessary for wound healing to occur and PPG-1 trideceth-6, propylene glycol, propylparaben, SD can augment the natural healing process. The effect of these formulations is most dramatically illustrated in the immune alcohol 38-b, SD alcohol 40, sodium acrylates copolymer, compromised patient whose ability to heal wounds is some Sodium borate, sodium cetearyl Sulfate, Sodium chloride, what Suppressed. Sodium citrate, Sodium lauryl Sulfate, Steareth-2, Steareth-21, Stearic acid, Stearyl alcohol, styrenefacrylates copolymer, 0209 Particulate bioactive glasses which are useful in Sulfated castor oil, thymol, titanium dioxide, tocopheryl treating wounds, burns, and abrasions typically have the acetate, triethanolamine, various coloring agents, water, following composition by weight percentage: US 2007/0275021 A1 Nov. 29, 2007

wound or burn which otherwise has a lower pH. This has an antimicrobial effect when bioactive glass is used and when used in combination with an antibiotic permits the antibiotic Component Percent to function by activating various growth factors implicated SiO2 40-60 in tissue repair. These reactions cause a higher negative CaO 1O-30 Surface charge on the glass Surface and the development of Na2O 1O-35 a high specific Surface area (e.g., from 0.5 m2/g by 12 hours) POs 2-8 CaF2 O-2S which attracts collagen, fibronectin and cells. Moreover, the B.O. O-10 bioactive glass provides for the precipitation of calcium and KO O-8 phosphorous naturally present in wound exudate and blood MgO O-5 which cause the rapid formation of a calcium and phosphate layer that may incorporate collagen, fibrin and fibronectin to stabilize the wound quickly and effectively. In some cases, 0210. The preferred composition of the bioactive glass is: wounds, burns, or abrasions healed with the composition or method of the present invention heal without the necessity of scab formation. That is, new epithelial tissue is formed SiO, 45 directly. CaO 24.5 Na2O 24.5 0217 When bioactive glass is to be used in combination POs 6 with an antibiotic it is preferable to mix the particulate bioactive glass and the antibiotic just before application to wound, burn, or abrasion. Accordingly, bioactive particulate 0211 The preferred particle size range for the bioactive glass and a topical antibiotic may be incorporated into a two glass is Small and less than 90 microns is recommended. part system wherein bioactive glass and topical antibiotic are Particle sizes less than 10 microns as well as less than 2 mixed and simultaneously applied. For example, a two part microns can also be used. Particles of such a small size range mixing syringe with two separate storage chambers and a generally are effective without illiciting any undesirable mixing chamber can be used. Other two part systems could immune response. also be used. For example, particulate bioactive glass can be incorporated into a bandage and the topical antibiotic can be 0212 Topical antibiotics are antibiotics suitable for skin applied to a wound, burn, or abrasion followed by applica treatment. Examples of Such antibiotics include: chloram phenicol, chlortetracycline, clyndamycin, clioquinol, eryth tion of the bandage. Alternatively, other two part delivery romycin, framycetin, gramicidin, fusidic acid, gentamicin, systems may be used. mafenide, mupiroicin, neomycin, polymyxin B, bacitracin, Soap and Bath Salt Products silver sulfadiazine, tetracycline and chlortetracycline. Those of ordinary skill in the art will appreciate that there are other 0218. The present invention includes novel formulations appropriate topical antibiotics Such as those listed in which incorporate bioactive glass into various brands of bath U.S.P.D., for example. and shower Soap in bar, liquid, gel form and bath salts such as the products marketed under the brand names Abra, Alba 0213 The bioactive glass and topical antibiotic can be Botanica, Albolene, Aloe Vera 80, Alpha Hydrox, Aroma, combined in any pharmaceutically acceptable carrier to Aura Cacia, Aussie, Aveeno, Baby Magic, Balmex, Bare facilitate application to a wound, burn, or abrasion. These Elegance, Basis, Body & Earth, Bodycology, Bubble Fac compositions can be combined with an ointment, white tory, Burt’s Bees, Calgon, Camay, Capri, Caress, Car petrolatum, mineral oil and other Substances known to those rington, Cashmere Bouquet, Cetaphil, Clairol, Clearasil, of ordinary skill in the art. Clearly Natural, Coast, Conti Castile, Cuticura, Dermalab, Desert Essence, Dial, Dove. Earth Therapeutics, Eucerin, 0214) These bioactive glass and topical antibiotic com Exorex, Fa, Fels Naptha. Formula 405, Gillette, Grandpa's, positions may also be combined with other wound, burn and Humco, Irish Spring, Ivory, Jason, Jean Nate, Jergens, abrasion treatments or dressings such as collagen, fibrin, Johnson & Johnson, Johnson's, Keri, Kirks Castile, Kiss My fibronectin, vitamin E. gauze, cotton, cellulosic, synthetic Face, Lava, Lever 2000, LifeBuoy, Lindora, Lowila, Lubri wound or burn dressings and other wound or burn dressingS/ derm, Lux, Masada, Moisturel, Nate Naturals, Naturade, treatments known to those of ordinary skill in the art. Nature's Gate, Neutrogena, Nivea, No Rinse, Noxzema, Oil Dressings of fiberglass and fiberglass made from fibers of of Olay, Oilatum, Packer's, Palmolive, PanOxyl Bar, Phi bioactive glass can also be used. soderm, Polytar, Purell, Pure & Natural, Pure Pleasure, 0215 Bioactive glass may also be used to a skin grafting Purpose, Revlon, Safeguard, San Francisco Soap, Sarah particulate bioactive glass may be added to the graft before Michaels, Sayman, Shield, Shikai, Simply Be Well, Soft it is placed in its intended location. The graft may also be soap, Stiefel, St. Ives Swiss Formula, State of Mind, Suave, further treated with a topical antibiotic prior to placement. Summer's Eve, Sween, The Healing Garden, Tom's of The application of bioglass to grafts is intended to increase Maine, Tone, Ultra Swim, Vaseline, Vel Beauty Bar, Village the likelihood that the graft will “take' and incorporate in the Naturals, White Rain, Yardley's of London, Zest, and prod host bed. ucts produced by high-end and generic manufacturers. 0216 While not being bound to any particular theory or 0219. The anti-microbial properties of bioactive glass are mechanism, it is believed that the high Surface area and particularly useful in Soap formulations. In addition, since reactivity of particulate bioactive glass provides for a release soap-making is generally an anhydrous process, creating of Sodium which increases pH and increase oxygen in the Such formulations is a relatively straightforward process. US 2007/0275021 A1 Nov. 29, 2007 22

Bioactive glass having certain particle sizes, create an abra acid, tealauryl Sulfate, tea-oleate, TEA-Stearate, titanium sive effect and are particularly well-suited for certain hand dioxide, tocopheryl acetate, triclosan, Sodium c 14-16 olefin Soaps (i.e., "Lava'). In addition, bioactive glass may be sulfonate, triethanolamine, trisodium EDTA, trisodium spheroidized for facial Soap similar to polymer beads etidronate, trisodium HEDTA, ultramarine blue, sodium included in certain facial cleaners. laureth Sulfate, water, disodium laureth Sulfo Succinate, coca midopropyl betaine, sodium laureth-13 carboxylate, fra 0220 Anti-inflammatory properties of bioactive glass are grance, glycerin, panthenol, aloe gel, ammonium chloride, particularly useful in both Soak and anti-itch Soak products. DMDM hydantoin, PEG-150 distearate, glycol distearate, Such novel products reduce redness and skin irritation. citric acid, polyduaternium-7, cocamide MEA, tetrasodium 0221) Generally, bath and shower soap in bar, liquid and EDTA, laureth-7, Various coloring agents, and various plant, gel form and bath salt products comprise Sodium or ammo mineral and vitamin extracts. nium hydroxide, tallow, coconut or palm kernel oil and 0224. The present invention provides for novel formula fragrance. tions of bath and shower soap in bar, liquid, and gel form and bath salt products by incorporating bioactive glass into a 0222 Common formulations of bath and shower soap in bar, liquid, and gel form and bath salt products comprise combination of any of the above-listed ingredients. triclocarboin, Soap, sodium tallowate, Sodium pamitate, Shampoo Detangling, Hair Mousse, Hair Gel and Hair Spray Sodium cocoate, palm kernelate types, water, PEG-6, methyl Products ether, fragrance, glycerin, Sorbitol, Sodium chloride, tetra 0225. The present invention includes novel formulations Sodium etibronate, pentasodium pentetate, BHT and various which incorporate bioactive glass into various brands of coloring agents. shampoo, hair detangling, hair mousse, hair gel and hair spray products Such as the products marketed under the 0223 Bath and shower soap in bar, liquid, and gel form brand names Adorn, Agree, Alberto VO5, Allercreme, Aloe and bath may also include one or more of the following: Vera 80, American Crew, Aqua Net, Aussie, Aussie Land, acetamidopropyl trimonium chloride, alkyl aryl polyether Baby Magic, Balsam, Breck, Brite-Life, Brylcreem, Citre alcohol, allantoin, aminomethyl propanol, ammonium lau Shine, Clairol, Color Soft, Condition 3-in-1, Consort, Cor reth Sulfate, ammonium lauryl Sulfate, behenamidopropyl texx, DeepEarth, Denorex, Dep, DHS, Dippity-Do, Dry pg-dimonium chloride, benzopheonone 4, BHT, biotin, Look, Dry Style, Elta, European Mystique, Final Net, boric acid, C12-15 alkyl benzoate, calcium pantothenate, Finesse, Flex, Free and Clear, Freeman, Freeze It, Frizz carbomer, cetyl alcohol, chromium hydroxide green, coca Control, Frizz Ease, Garden Botanika, Gillette, Good Sense, mide DEA, cocamidopropyl oxide, cocoa butter, cocobetane Groom Clean, Hask, Head & Shoulders, Henna Gold, Her PEG 18, cocoglyceryl ether sulfonate, coconut fatty acid, bold, Infusium 23, Tonil T, Ivory, Jason, Jeris, Jheri Red corn oil, cottonseed oil, decyl glucoside, diazolidinyl urea, ding, Jhirmack, John Frieda, Johnson & Johnson, Johnson's, dimethicone, dimethicone copolyol, disodium cocoyl, diso Joico, Kiss Kids, Kiss My Face, La Bella, L.A. Looks, dium EDTA, disodium phosphate, EDTA, ethoxydiglycol, Landers, Looney Tunes, L'Oreal, Loving Care, Marci Gelle, ethyl alcohol, etidonic acid, etidronic acid, glyceryl laurate, Mane in Tail, Mink Difference, Nestle, Neutrogena, Nexxus, glycol Stearate, glycolipids, guar hydroxypropyltrimonium Nizoral, No Rinse, Ogilvie, Pantene, Paul Mitchell, Perma chloride, hexylene glycol, hydrolyzed silk protein, hydrox Soft, Pert Plus, Physique, Pinaud, Protein 29, Pro-V. Prell, propyl, hydroxypropyl methylcellulose, imidazolidinyl urea, Progaine, Psssssst, Queen Helene, Rave, Redken, Revlon, iodopropyl butylcarbamate, isopropyl lanolate, isopropyl Royal Crown, Russ Kalvin's Generic, Salon Grafix, Salon myristate, lanolin oil, lauramide DEA, lauramide MEA, Selectives, Salon Style, Scalpicin, Sebastian, Sebucare, laureth-10, laureth-23, lauric acid, lauryl alcohol, lauryl Sebulex, Sebutane, Selsun Blue, St. Ives Swiss Formula, Sulfate, lecithin, lemon juice, linoleamide DEA, magnesium Stiff Stuff, Style, Suave, Superset, Tegrin, The Dry Look, cocoate, magnesium laurate, magnesium Stearate, methyl Theorie, Thermasilk, Thicker Fuller Hair, Tigi, Toms of gluceth-10, methyl gluceth-20, methylcellulose, methyl Maine, Top Brass, Tres Flores, Tresemme, Ultimate Look, chloroisothiazolinone, methylisothiazolinone, methylpara UltraSwim, University Medical, Vaseline, Venture, Vidal ben, mineral oil, oleate/cocoate, oleyl alcohol, oleyl lactate, Sassoon, Vital Care, Vitalis, White Rain, Wildroot, Willow palm acid, palmitic acid, paraffin, PEG 55 propylene glycol Lake, Youth Hair, Zincon, and products produced by high oleate, PEG 7 glyceryl cocoate, PEG-12, PEG-120 methyl end and generic manufacturers. glucose dioleate, PEG-20, PEG-3 distearate, PEG-5M, PEG-75, PEG-8, PEG-90M, petrolatum, phenoxyethanol, 0226 Generally, shampoo and hair detangling products polyduaternium-10, polyduaternium-22, polysorbate 20, comprise ammonium lauryl Sulfonate, triethanolamine, lau PPG-5-ceteth-20, propylene glycol, propylparaben, retinyl ramide DEA, lecithin, glycol Stearate, methylparaben and palmitate, silk peptide, Sodium benzoate, Sodium citrate, methylisothiozoline. Sodium cocglyceryl ether Sulfonate, Sodium cocoyl 0227 Bioactive glass and sol-gel derived bioactive glass glutamate, Sodium cocoylisethionate, Sodium dodecylben can react with aqueous fluids to form a solution that is rich Zene Sulfonate, Sodium dodecylbenzenesulfonate, sodium in inorganic elements, such as calcium, phosphorous, formate, Sodium hydroxide, Sodium isethionate, sodium Sodium and silicon. Incorporating bioactive glass into Such laurate, Sodium laureth Sulfate, sodium laureth Sulfate, hair care products allows these inorganic elements to pre Sodium lauroyl lactylate, Sodium lauroyl sarcosinate, cipitate on hair to form a mineralogical layer (i.e., hydroxya Sodium myreth Sulfate, sodium palm kernelate, sodium patite). This mineralogical layer is expected to add strength ricinoleate, sodium Stearate, Sodium styrenefacrylates to hair, while also possibly improving the “softness” and copolymer, sodium styrenel acrylates/divinylbenzene “style-ability” of hair. In addition, bioactive glass provides copolymer, Sodium Sulfate, Stearamidopropyl PG-dimonium an anti-microbial effect which reduces the occurrence of chloride phosphate, Stearic acid, Sunflower seed oil, tallow dandruff. US 2007/0275021 A1 Nov. 29, 2007

0228 Common formulations of shampoo and hair detan hydroxide, sodium hydroxymethyglycinate, sodium laureth gling products comprise water, ammonium laureth Sulfate, Sulfate, Sodium laureth-13 carboxylate, sodium laurimino ammonium lauryl Sulfate, glycol distearate, dimethicone, dipropionate, Sodium lauroyl sarcosinate, Sodium lauryl cocamide MEA, cetyl alcohol, fragrance, polymethacryla Sulfate, sodium methylparaben, Sodium myreth Sulfate, midopropyl, trimonium chloride, sodium citrate, DMDM Sodium oleth Sulfate, Sodium phosphate, sodium styrene? hydantoin, sodium chloride, PEG-14M, dihydrogenated tal acrylates/divinylbenzene copolymer, Sodium sulfate, lowmidoethyl hydroxyethylmonium, disodium EDTA, phe sodium trideceth sulfate, solubilized coal tar extract, soluble noxyethanol, citric acid, methyldibromoglutaronitrile, collagen, soyamide DEA, stearyl alcohol, talloweth-60 ammonium Xylene-Sulfonate and various coloring agents. myristylglycol, TEA-dodecylbenzenesulfonate, TEA-dode cylphenylsulfonate, TEA-lauryl sulfate, tetrasodium EDTA, 0229 Shampoo and hair detangling products may also tissular fluid extract, titanium dioxide, tocopheryl acetate, include one or more of the following: 2-oleamido-1,3- topical tar Solution, trideceth-12, triethanolamine lauryl Sul octadecanediol (ceramide-r), acetamide MEA, acrylates/ fate, trimethylsilylamodimethicone, wheat oligosaccharides, C10 alkyl acrylate crosspolymer, acrylic acid polymer wheatgermanidopropyl dimethylamine, Xanthan gum, yeast (carbomer 1342), alcohol, aloe Vera gel, aluminum starch extract, hydrolyzed soy protein, sodium PCA, ethoxydigly octenylsuccinate, amodimethicone, arginine, benzophe col, linoleamidopropyl PG-dimonium chloride phosphate, none-3, benzophenone-4, biotin, butylated hydroxytoluene, hydrogenated polydecene, trimethylolpropane, phenoxy butylene glycol, butylparaben, carbomer, carboxylic acid, cetrimonium chloride, chloroxylenol, coal tar distillate, ethanol and various fruit, mineral and vitamin extracts. cocamide DEA, cocamide MIPA, cocamidopropyl betaine, 0230. The present invention provides for novel formula cocamidopropyl hydroxysultaine, cocamidopropylamine tions of shampoo and hair detangling products by incorpo oxide, cocobetaine, cocodimonium hydroxypropyl hydro rating bioactive glass into a combination of any of the lyzed hair keratin, cocotrimonium chloride, cyclomethicone, above-listed ingredients. cysteine, DEA-methoxycinnamate, decyl polyglucose, dia Zolidinyl urea, dimethiconol, dimethyl ether, disodium coco 0231 Generally, hair mousse, hair gel and hair spray amphodiacetate, disodium laureth SulfoSuccinate, disodium products comprise mineral oil, lanolin, Stearic acid and Zinc lauroamphodiacetate, disodium oleamido MEA Sulfo Succi pyrithione. nate, disodium phosphate, disodium ricinoleamido, ergocal 0232 Common formulations of hairmousse, hair gel, and ciferol, ethylparaben, glycerin distearyldimonium chloride, hair spray products comprise water, isobutane, polyduater glycerin, glycol Stearate, glycosaminoglycans, guar hydrox nium-4, propane, propylene glycol, C9-11 pareth-8, DMDM ypropyltrimonium chloride, hydrochloric acid, hydrolyzed hydantoin, fragrance, panthenol, disodium EDTA, panthenyl animal protein, hydrolyzed collagen, hydrolyzed keratin, ethyl ether, pantethine, lauramine oxide, keratin amino acids hydrolyzed silk, hydrolyzed vegetable protein, hydrolyzed and citric acid. wheat protein, hydrolyzed wheat starch, hydrolyzed yeast, hydroxypropyl guar hydroxypropyltrimonium chloride, 0233 Hair mousse, hair gel, and hair spray products may hydroxypropyl methylcellulose, hydroxypropyltrimonium also include one or more of the following: acetamide MEA, hydrolyzed wheat protein, imidazolidinyl urea, inositol, acrylate copolymer, acrylates/dimethicone/methacrylate iodopropyl butylcarbamate, iodopropynyl butylcarbamate, copolymer, alanine, alcohol denat, allantoin, aminoethylpro isobutane, isolaureth-6, isostearamidopropyl morpholine panol, aminomethyl propanol, ammonium benzoate, ammo lactate, keratin amino acids, ketoconazole, lactamide MEA, nium hydroxide, amodimethicone, arachidonic acid, argin lauramide DEA, lauramphoglycinate, laureth-10, laureth ine, ascorbyl palmitate, behenic acid, benzophenone-3, 23, laureth-4, laureth-6, lauryl alcohol, lecithin, magnesium benzophenone-4, betaine, boric acid, butyl ester of PVM/ citrate, magnesium laureth Sulfate, measulfoSuccinate, men MA copolymer, C13-14 isoparaffin, calcium pantothenate, thol, methenamine, methoxypropylgluconamide, methyl carbomer, carbopol, catalase, cetearyl octanoate, ceteth-16, chloroisothiazolinone, methylisothiazolinone, methylpara ceteth-20, cetrimonium bromide, cetrimonium chloride, ben, mica, octoxynol-40, octyl Dimethyl PABA, octyl cetyl alcohol, chlorhexidine dihydrochloride, cocamide hydroxy Stearate, octyl methoxycinamate, olealkonium chlo DEA, cocamidopropyl betaine, cocamidopropyl hydrox ride, palmitic acid, pantethine, panthenol, panthenyl ethyl ySultaine, collagen, cyclomethicone, DEA-methoxycin ether, pantothenic acid, PEG-12, PEG-120 methyl glucose namate, diazolidinyl urea, diisobutyl adipate, dimethicone dioleate, PEG-15 coco polyamine, PEG-150 distearate, copolyol, dimethiconol, dimethyl ether, dimethyl lauramine PEG-23M, PEG-27 lanolin, PEG-55 propylene glycol ole isostearate, dimethyl Stearamine, dioctyl sebacate, distear ate, PEG-60 almond glycerides, PEG-600, PEG-7 glyceryl lydimonium chloride, ethosulfate, ethyl ester of PVM/MA cocoate, PEG-80 sorbitan laurate, phosphoric acid, copolymer, ethyldimonium, gelatin, glutamic acid, glycerin, phytantriol, phytic acid, polyduaternium-16, polyduater glycine, hyaluronic acid, hydrofluorocarbon 152A, hydro nium-10, polyduaternium-11, polyduaternium-30, lyzed elastin, hydrolyzed soy protein, hydrolyzed wheat polyduaternium-4, polyduaternium-46, polyduaternium-7. protein, hydrolyzed wheat starch, hydrophilic polyether polysorbate 20, polysorbate 80, potassium cocoyl hydro polyurethane, hydroxyethyl cellulose, hydroxypropyl guar, lyzed collagen, potassium sorbate, PPG-12 buteth-16, hydroxypropyl methylcellulose, iodopropynylbutylcarbam PPG-5 laureth 5, PPG-9, propylene glycol, propylparaben, ate, isododecane, isopropyl alcohol, isosteareth-10, keratin pyrithione Zinc, quaternium-15, quaternium-22, quaternium protein, lactamide MEA, laneth-16, lauramide DEA, laura 75, quaternium-80, retinyl palmitate, ricinoleamidopropyl mide MEA, laureth-11, laureth-23, laureth-4, laureth-7, lau ethyldimonium ethosulfate, SD alcohol 40, serum protein, reth-9, lecithin, linoleamidopropyl, linoleic acid, lysine, silk amino acids, silk protein, Silsesquioxane copolymer, lysine hydroxypropyl trimonium chloride, methylchloroio sodium benzoate, sodium C14-17 alkyl SEC sulfonate, Sothiazolinone, methylchloroisothiazolinone, methylchlor Sodium cocoyl sarcosinate, Sodium glutamate, sodium oisothiazolinone, methylisothiazoline, methylisothiazoli US 2007/0275021 A1 Nov. 29, 2007 24 none, methylparaben, mineral oil, myristoyl hydrolyzed collagen, niacinamide, SD alcohol 40, nonoxynol-10, octyl -continued hydroxy Stearate, octyl salicylate, octylacrylamide/acrylates copolymer, octylacrylamide/acrylates/butylaminoethyl INGREDIENTS wt % meth, octylmethoxycinnamate, olealkonium chloride, oleic Fragrance (Wildberry AFF #24551) O.2 acid, oleth 20, oleth-16, palmitic acid, palmitoyl myristyl Citric Acid monohydrate powder 3.0 serinate, PEG-15 cocamine chloride, PEG-40 hydrogenated Schott Glass Bioactive (<41 ave. part. size) 3.0 castor oil, PEG-6 cocamide, PEG-60 hydrogenated castor 1OO.O oil, PEG-75 lanolin, PEG-8 sorbitol, phenoxyethanol, phe nyl trimethicone, phospholipids, phytantriol, polyacryla mide, polyduaternium-11, polyduaternium-46, polyduater EXAMPLE 12 nium-7, polysorbate 20, polysorbate 80, polyZophenone-4, potassium dimethicone copolyol panthenyl phosphate, Hair Shampoos with 45s5 Glass potassium hydroxide, potassium sorbate, PPG-12-PEG-50 lanolin, PPG-5-ceteth-20, PPG-9 diethylmonium chloride, Three Separate Formulas: CPD3-15A, B, C, D proline, PVP. pyridoxine HCL, quaternium-15, retinyl palmitate, ribonucleic acid, serine, silk amino acids, silk 0238 protein, sodium benzoate, sodium C13-15 pareth-8 butyl phosphate, sodium C13-15 pareth-8 phosphate, sodium C14-16 olefin sulfonate, sodium chloride, sodium cocoyl isethionate, sodium hydroxymethylglycinate (amino acid INGREDIENTS derived), sodium PCA, sorbitol, soyamide DEA, stearalko Standapol ES-2 Consultaine C-50 nium chloride, Steareth-16, Steareth-2, Stearic acid, Stearyl Foamid C S.O S.O S.O S.O alcohol, tea-dodecylbenzenesulfonate, tetrasodium EDTA, Deionized Water 48.0 48.0 48.0 48.0 threonine, tocopheryl acetate, trideceth-12, triethanolamine, Phenobact 1.O 1.O 1.O 1.O trisopropanolamine, urethane/C1-C20 peg alkyl copolymer, Citric Acid monohydrate powder 1.O 1.O Schott Glass 45s5 (<4 ave. S.O S.O VA/crotonates/vinyl neodecandate copolymer, various fruit, part. Size) plant, vitamin extracts, wheat germamidopropyl ethyldimo nium ethosulfate, yeast extract, isobutane, AMP-isostearoyl 1OOO 94.0 95.0 99.0 hydrolyzed soy protein, butylene glycol, and SD alcohol 40.

0234. The present invention provides for novel formula EXAMPLE 13 tions of hair mousse, hair gel, and hair spray products by incorporating bioactive glass into a combination of any of Hair Shampoos with Bioactive Glass Formulas the above-listed ingredients. CPD3-31 A, B, C, D 0235. The antimicrobial and pH effects of bioactive glass 0239) are particularly useful in shampoo and other hair care products to reduce bacteria and to normalize the pH level of hair. In addition, the ability of bioactive glass to release minerals which bind to the hair surface is useful for enhanc INGREDIENTS ing hair strength, body, and Volume. Steo CS-230 Crosultaine C-50 0236 Examples 11-13 below provide exemplary embodi Foamid C ments of shampoo formulations incorporating bioactive Deionized Water Phenobact glass, including Sol-gel-derived bioactive glass. Citric Acid monohydrate powder Bioglass (<51 ave. part. Size) EXAMPLE 11 Composition of Hair Shampoo with Bioactive Glass Initial pH Values 0237) pH 31A 8.9 pH 31B 8.2 INGREDIENTS wt % pH, 31C 5.7 Standapol ES-2 3O.O pH 31D 4.8 Crosultaine C-50 1O.O Foamid C S.O 24 Hour pH Values Deionized Water 47.3 Jaguar C-14S O.S pH-31A 9.6 Phenobact 1.O pH-31B 9.2 US 2007/0275021 A1 Nov. 29, 2007

pH 31C 8.5 EDTA, tribehenin, triclosan, triclosan, triethyl citrate, urea, various coloring agents, various mineral and Vitamin pH 31D 7.2 extracts, vegetable oil, vegetable starches, water, Xanthan Anti-Perspirant and Deodorant Products gum, Zinc oxide. 0240 The present invention includes novel formulations 0245. The present invention provides for novel formula which incorporate bioactive glass into various brands of tions of anti-perspirant and deodorant products by incorpo anti-perspirant and deodorant products in powder, creme, rating bioactive glass into a combination of any of the roll-on, aerosol and stick form Such as the products marketed above-listed ingredients. under the brand names 5 Day, Allercreme, Almay, Aqua Velva, Arm & Hammer, Arrid XX, Ban, Banish, Brut, 0246 The antimicrobial, anti-inflammatory, and hygro Certain Dri, Clearly Fresh & Natural, Crystal Clean, Crystal scopic effects of bioactive glass are particularly useful in Stick, Degree. Desert Essence, Dove, Dry Idea, English anti-perspirant and deodorant products to reduce bacteria, Leather, Gillette, Hi & Dri, Jason, Jockey Club, Kiss My odor and moisture. Face, Lady Crystal, Lady Mitchum, Lady Speed Stick, Aftershave and Shaving Lotion Products Lady's Choice, Mennen, Mitchum, Nair, Nature's Gate, Nautica, Nullo, Old Spice, Pinaud, Power Stick, Revlon Hi 0247 The present invention includes novel formulations & Dri, Right Guard, Secret, Soft & Dry, Speed Stick, Suave, which incorporate bioactive glass into various brands of Sure, Teen Spirit, Tom's of Maine, Tussy, Soft & Dri, aftershave and shaving lotion products such as the products Yodora, and products produced by high-end and generic marketed under the brand names Aceite. Afta, Aqua Velva, manufacturers. Aspen, Brut, Bump Fighter, Burt’s Bees, Earth Science, Edge, Flents, Gillette, Hoyt Co., Ice Sport, Todex, Jason, 0241 The anti-microbial and hygroscopic properties of Jovan, Mennen, Old Spice, Pinaud, Pomada, Requa, Sam bioactive glass in deodorant and anti-perspirant formulation borns, Saxon, Skin Bracer, Super Macho, Williams, and control odor causing bacteria, while the anti-inflammatory products produced by high-end and generic manufacturers. properties reduce underarm irritation. Bioactive glass may be incorporated into Solid amorphous forms, similar to 0248. Aftershave and shaving lotion formulations which deodorant "crystals'. A wipe with the polished solid form include bioactive glass provide excellent anti-inflammatory also has an anti-microbial effect. effects to reduce post-shaving irritation. 0242 Generally, anti-perspirant or deodorant products 0249 Generally, aftershave and shaving lotion products comprise aluminum chlorohydrate, aluminum chloride, Zir comprise propylene glycol, menthol and benzoic acid. conium chlorides or triclosan. 0250 Common formulations of aftershave and shaving 0243 Common formulations of anti-perspirant and lotion products comprise SD alcohol 40, water, glycerin, deodorant products in Stick, roll-on, aerosol, creme, pad, and menthol, fragrance, benzophenone-1 and various coloring powder form comprise active ingredients consisting of alu agents. minum zirconium tetrachlorohydrex gly or aluminum chlo 0251. Aftershave and shaving lotion products may also rohydrate. include one or more of the following: aloe extract, aluminum 0244 Anti-perspirant and deodorant products may also starch octenylsuccinate, benzoic acid, benzyl alcohol, BHT, include one or more of the following: alcloxa, alcohol, C12-15 alkyl benzoate, carbomer 980, cassaya flour, allantoin, aloe Vera gel, aluminum chloride, PPG-14 butyl cyclomethicone, dimethicone, disodium EDTA, ethylenedi ether, cyclomethicone, baking soda, behenyl alcohol, ben amine, isodecyl oleate, isopropyl myristate, methylparaben, Zethonium chloride, benzoic acid, BHT, C12-15 alkylben myristyl propionate, panthenol, PEG/PPG-17/6 copolymer, Zoate, C18-36 acid triglyceride, ceteareth-20, cetearyl alco PEG-60 hydrogenated castor oil, PG, phenoxyethanol, hol, citric acid, corn starch, cyclomethicone, polysorbate 80, PPG-15, propylene glycol, SD alcohol 39-C, cyclopentasiloxane, cyclotetrasiloxane, dibenzylidene Sorbi Stearyl ether, tetrahydroxypropyl, tocopheryl acetate, tri tol, dicaprylate/dicaprate, diisopropyl adipate, diisopropyl ethanolamine, various plant, fruit, and vitamin extracts, sebacate, dimethicone, dipropylene glycol, L. panthenol, Xanthan gum, propylene glycol, benzoic acid, benzophe farnesol, fragrance, glycerin, glyceryl oleate, glyceryl Stear none-2, BHT, PG, and benzyl alcohol. ate, hectorite, hydrofluorocarbon 152A, hydrogenated castor 0252) The present invention provides for novel formula oil, hydrogenated polyisobutane, hydrogenated vegetable tions of aftershave and shaving lotion products by incorpo oil, hydroxyethylcellulose, isobutane, isopropyl alcohol, iso propyl myristate, laureth-4, methylparaben, mineral oil, rating bioactive glass into a combination of any of the myristyl myristate, octoxynol-9, octyl isononanoate, octyl above-listed ingredients. palmitate, octyldodecanol, PEG-100 stearate, PEG-20, 0253) The anti-inflammatory effects of bioactive glass are PEG-25 propylene glycol stearate, PEG-8 distearate, penta particularly useful in aftershave and shaving lotion products decalactone, petrolatum, PG, phenyl trimethicone, polyeth to reduce inflammation. ylene, polyol, polysaccharides, polysorbate 20, polythylene, potassium alum, potassium sorbate, PPG-14 butyl ether, Shaving Products PPG-1-PEG-9 lauryl glycol ether, propane, propylene car 0254 The present invention includes novel formulations bonate, propylene glycol, propylparaben, purified clay, which incorporate bioactive glass into various brands of quaternium-18, SD alcohol 40, silica, silk powder, sodium shaving products in creme, gel, powder and Soap form such bicarbonate, Sodium laureth 13 carboxylate, sodium Stearate, as the products marketed under the brand names Afta, Alba soyaethyl morpholinium ethosulfate, starch, Stearyl alcohol, Botanica, Aveeno, Barbasol, Brut, Bump Stopper, Burma talc, T-butyl alcohol, T-butyl hydroquinone, tetrasodium Shave, Burt’s Bees, CAM, Colgate, Earth Science, Edge, US 2007/0275021 A1 Nov. 29, 2007 26

Everready, Gillette, Jason, Kiss My Face, Lady Legs, Magic 0261 Generally, depilatory, epilatory, and hair bleaching Platinum, Magic Shaving Powder, Noxzema, Old Spice, products comprise the active ingredient calcium thioglyco Palmolive, Pinaud, Remington, Requa, Rise, Shave in the late or calcium hydroxide. Shower, Skin Bracer, Skinnate, Skintimates, Soft Shave, 0262 Common formulations of depilatory, epilatory or Tom’s of Maine, Williams, and products produced by high hair bleaching products comprise water, mineral oil, calcium end and generic manufacturers. hydroxide, cetearyl alcohol, calcium thioglycolate, sodium 0255 Generally, shaving products in cream gel, powder, thioglycolate, ceteareth-20, various floral and herbal, and or soap form comprise a moisturizer Such as aloe gel and a Vitamin extracts, and various coloring agents. protectant such as Stearic acid. 0263. Depilatory, epilatory and hair bleaching products 0256 Common formulations of shaving products cream may also include one or more of the following: ammonium gel, powder, or Soap powder comprise water, triethanola bicarbonate, benzalkonium chloride, camphor, cetyl alcohol, mine, palmitic acid, Stearic acid, isopentane, monoglycer chamomile extract, citric acid, dimethicone, fragrance, glyc ides, sorbitol, PEG-90M, PVP fragrance, isobutane, various eryl Stearate, hydrogen peroxide, iron oxides, isopropyl coloring agents, and various floral, Vitamin, and mineral myristate, isopropyl palmitate, isopropyl Stearate, maltodex eXtractS. trin, octoxynol-9, pentaerythrity1 tetracaprylate/caprate, pet rolatum, phosphoric acid, potassium Sorbate, SD alcohol 40, 0257 Shaving products in cream gel, powder, or soap Stearamidopropyl dimethylamine, Stearyl Stearate, Sweet form may also include one or more of the following: almond oil, calcium glyceryl Stearate, octyl palmitate, 1-dodecanol, allantoin, aloe extract, aluminum starch octe Stearic acid, propylene glycol, triethanolamine, imidazolidi nylsuccinate, ammonium hydroxide, barium Sulfide, behen nyl urea, PEG-100 stearate, soluble collagen, lanolin alco trimonium methosulfate, benzaldehyde, benzophenone-1, hol, disodium EDTA, carbomer, methylparaben, thioglyco benzyl alcohol. BHA, BHT bromelain, butane, C16 to C22, late, Stearyl alcohol, and silica. calcium carbonate, calcium hydroxide, calcium thioglyco late, carbomer, cellulose polymer, cetearyl alcohol, cetyl 0264. The present invention provides for novel formula alcohol, chlorhexidine gluconate, corn starch, diazolidinyl tions of depilatory, epilatory, and wax products by incorpo urea, dimethicone, dimethyl Sulfate quaternized, dioctyl rating bioactive glass into a combination of any of the Succinate, esters with triethanolamine, fatty acid esters, above-listed ingredients. glycerides, glycerin, glyceryl oleate, glyceryl Stearate, 0265. The anti-inflammatory and anti-microbial effects of guanidine carbonate, hydroxyethycellulose, isopropyl bioactive glass are particularly useful in depilatory, epila myristate, isopropyl palmitate, lanolin alcohol, lanolin oil, tory, and wax products to reduce inflammation, bacteria, and laureth-23, lecithin, menthol, methylparaben, milk protein, odor. myristyl propionate, nonoxynol 10, oxidized polyethylene, paraffin, PEG 14M, PEG 150 pentaerythrityl tetrastearate, Toothpaste Products PEG 6 caprylic/capric glycerides, pentane, pentasodium 0266 Bioactive glass may also be incorporated into vari pentetate, petrolatum, phenycarbinol, polyethylene, ous brands of toothpaste products such as the products polyduaternium 10, polysorbate 20, polysorbate 60, potas marketed under the brand names Act, Aim, Aquafresh, Arm sium myristate, PPG-12-PEG-65, propane, propyl gallate, & Hammer, Biore, Biotene, Boiron, Breath Remedy, Brite propylene glycol, propylparaben, resorcin, retinyl palmitate, Life. Butler, Cepacol, Close-Up, Colgate, Crest, Dentu SD alcohol 40, soap, sodium benzoate, sodium borate, Creme, Desert Essence, Enamelon, Fixodent, Fresh N Sodium chloride, Sodium lauryl Sulfate, Sodium metasilicate, Brite, Gel-Kam, Gleem, Interplak, Keep, Kids Dental Kare, Sodium myristate, Stearyl alcohol, TEA Stearate, teamaleate, Listerine, Mentadent, Natural White, Nature's Gate, Orajel, tetrasodium etibronate, titanium dioxide, tocopheryl acetate, Oral-B, Pearl props, Pepsodent, Plak Smacker, Plus+White, triclosan, isobutane, cyclomethicone, and C12-15 alkylben Pollident, Q-Dent, Rembrandt, Sensodyne. Thermodent, ZOate. Tom’s of Maine, Topol, Ultra Brite, Ultra Plus, Vademecum, Viadent, and products produced by high-end and generic 0258. The present invention provides for novel formula tions of shaving cream and gel products by incorporating manufacturers. bioactive glass into a combination of any of the above-listed 0267 Generally, toothpaste products comprise fluoride, ingredients. triclosan, pyrophosphates, silica, baking Soda, potassium nitrate and natural and/or artificial flavoring. 0259. The antimicrobial effects of bioactive glass are particularly useful in shaving products to reduce bacteria 0268 Common formulations of toothpaste products com and the possibility of infection from nicks and cuts inflicted prise sodium fluoride, water, Sorbitol, hydrated silica, Zinc during shaving. citrate trihydrate, sodium lauryl sulfate, SD alcohol 38-B, flavor, cellulose gum, Sodium saccharin, and various color Depilatory and Hair Bleaching Products ing agents. 0260 The present invention includes novel formulations 0269 Toothpaste products may also include one or more which incorporate bioactive glass into various brands of of the following: acesulfame potassium, alumina, ammo depilatory, epilatory and hair bleaching products in cream, nium chloride, beta-d-glucose, calcium peroxide, calcium wax, and powder form such as the products marketed under Sulfate, carbomer, carboxymethylcellulose, citric acid, coen the brand names Andrea, Ardell, Better-Off, Bikini Bare, Zyme Q10, dicalcium phosphate dihydrate, glycerin, hydro Hair Off, Jolen, Nair, Natural, Neet, Nudit, One Touch, Sally gen peroxide, lactoperoxidase, glucose oxidase, lysozyme, Hanson, Zip, and products produced by high-end and magnesium chloride, methylparaben, microdent poloxamer, generic manufacturers. monoammonium phosphate, papain, PEG 300, PEG 60, US 2007/0275021 A1 Nov. 29, 2007 27 hydrogenated castor oil, PEG-12, PEG-32, PEG-6, PEG-75, phosphoric acid, poloxamer 407, poloxapol 1220, Potassium -continued Nitrate, potassium Sorbate, potassium thiocyanate, propy lene glycol, propylparaben, pyrophosphate, SD alcohol Component Percent 38-B, silica, simethicone, Sodium benzoate, sodium bicar KO O-8 bonate, Sodium carbonate, sodium carrageenan, Sodium MgO O-5 chloride, Sodium citrate, Sorbitol and related polyols, sodium hydroxide, Sodium lauroyl sarcosinate, sodium monofluo rophosphate, Sodium monofluurophosphate, Sodium percar 0274. Such bioactive glasses provide an efficacious mate bonate, Sodium phosphate, Sodium tripolyphosphate, tet rial for interaction with the tooth structure and do not trigger rapotassium pyrophosphate, tetrasodium pyrophosphate, an overwhelmingly adverse immune response. titanium dioxide, trisodium phosphate, PEG-8, various natu ral and artificial flavorings, Xanthan gum, Zinc chloride, 0275 Bioactive glasses of specified particle sizes are Zirconium silicate, thymol, methyl salicylate, and benzoic particularly useful in toothpaste and mouthwash formula acid. tions especially when Small and very Small particles are combined. For example, when compositions including Small 0270 Bioactive glass compositions are useful in, for particles that are capable of bonding with tooth structure example, enamel remiralization, incipient caries remineral (e.g., less than about 90 microns) as well Smaller particles ization, carious dentin remineralization, caries prevention, (e.g., less than about 10) are used in combination, the larger arresting decay, reversing decay, anti-caries, pit and fissure of these particles adhere to tooth structure and act as ionic sealants, prophylactic pastes, fluoride treatments, dentinal reservoirs while the smaller are capable of entering and sealants, etc. Bioactive glass may be included in toothpastes, lodging inside of various tooth structure Surface irregulari liners, bases, gels, and restorative material e.g., packing, ties. The larger of these particles provide a reservoir of indirect pulp capping agent, etc. Such compositions are also additional calcium and phosphorous so that the mineraliza useful in the treatment of Surfaces after periodontal Surgery tion, or depositing of the calcium phosphate layer begun by to decrease dentinal sensitivity and enhance tissue attach the Small particles can continue. Additional calcium and ment. These compositions are active in treating various phosphorous can be leached to all tooth structure as well as defects associated with a variety of dental and other condi to particles which have become attached to the inside or at tions and actually chemically and physically bond to the the openings of Surface irregularities of tooth structure Such tooth thereby remineralizing tooth structure. as dentinal tubules. This in turn provides for continuation of the entire reaction and continued growth of the smaller of 0271 As referred to herein, remineralization is the for these particles which have lodged inside or over the open mation of hydroxyapatite. The formation of hydroxyapatite ings of Such Surface irregularities and can result in effec begins with exposure of a bioactive glass composition to tively coating or filling the Surface irregularity. This excess aqueous solutions. It is believed that the sodium ions (Na+) in the bioactive glass exchanges with H+ ions in body fluids concentration of ions of calcium and phosphorous is neces causing pH to increase. Calcium and phosphorus then sary for continued reaction of the smaller of these particles migrate from the bioactive glass forming a calcium-phos to take place because the Smaller particles quickly exhaust phorous rich Surface layer. An underlying silica rich Zone their ions as a result of their relatively high surface area. The slowly increases as the Sodium ion in the bioactive glass larger of these particles will react and release their ions more continues to exchange with the hydrogen ion of the solution. slowly as a longer term effect. Furthermore, the larger of After time, the calcium-phosphorous rich layer crystallizes these particles will mechanically abrade the tooth surface into a hydroxyapatite material. Collagen can become struc opening various Surface irregularities allowing Small par turally integrated with the apatite agglomerates. An effective ticles to enter and react with the surface irregularity. remineralizing amount refers to any amount capable of 0276. This effect is very beneficial in a variety of appli forming hydroxyapatite. cations. For example, in preventing caries or decay, the composition of the present invention is capable of penetrat 0272. As the term “a tooth structure' is used herein, it is ing into the depths of the Smallest of Surface irregularities intended to refer to any feature or features of a tooth and receiving a continued Supply of ions from larger nearby including but not limited to enamel, dentin, pulp, tooth root particles so that it is able to grow after exhausting its stored structure, cementum, root dentin, coronal dentin, any dental ion Supply. This is also very useful in sealing pits and manufacture, etc. fissures and a much more effective and long lasting seal is 0273 For example, the following composition by weight obtained. will provide a bioactive glass suitable for toothpaste and 0277 For some applications extremely small particles are mouthwash formulations: used. For example, particles that are in the range of 2 microns are used to fit inside dentin tubules that are approxi mately 1-2 microns in diameter. The occlusion of these Component Percent tubules leads to a significant reduction in the amount of sensitivity after, for example, periodontal Surgery. A particu SiO2 40-60 CaO 1O-30 larly effective combination includes a mixture of particles, NaO 1O-35 wherein the mixture comprises particles less than 2 microns POs 2-8 and particles more than 45 microns. CaF2 O-2S B2O3 O-10 0278. Theses bioactive glass compositions generally do not require time to set and are not easily washed away by US 2007/0275021 A1 Nov. 29, 2007 28 mechanical abrasion caused by brushing, exposure to mild phosphate may be from saliva itself, or may be formulated acids in food, salivary flow or other liquids which normally into the oral hygiene composition. come in contact with the teeth. Such compositions can generally withstand significant agitation, rinsing with water 0286 The addition of fluoride in bioactive glass compo and long term soaking in simulated saliva for five days. sitions enhances and strengthens the tooth structure. Other Moreover, many of the Small particles do not require a set examples include Solgel glasses having, for example, about time because they begin to chemically react and adhere to 40 to about 86% by weight SiO, substantially no amount of tooth structure as soon as they come into contact with these sodium, about 6-36% by weight Ca and about 2-12% by Surfaces and fluids naturally present in the mouth. Although weight P0s. Such compositions are effective with a single application, it 0287 Bioactive glass compositions comprising is likely that multiple applications will be more efficacious. extremely small particles may also be used. For example, particles that are in the range of 2 microns are beneficial. 0279. As previously noted, relatively small particulate Particle size may be determined by Scanning electron bioactive glass does not generate a significant immune microscopy or laser light scattering techniques (e.g., Coulter response. Moreover, it is generally not engulfed by mac LS100). As stated previously, relatively small bioactive rophages and rendered inactive. particulate glass does not generate a significant immune 0280. In addition, these bioactive glass compositions are response. Moreover, it is generally not engulfed by mac capable of providing a bioactive layer that will form a new rophages and rendered inactive. structural layer which is a lasting remineralization of tooth 0288 These compositions may be formulated as oral structure. This has been verified by the reformation of a hygiene compositions such as dentifrices, toothpaste, gels, hydroxycarbonate apatite layer on dentin Surfaces after powders, mouthwashes, irrigating Solutions, and presenta treatment with bioactive glass compositions with Fourier tions for Sucking or chewing Such as gums, pastilles, tablets, Transform Infrared spectroscopy (FTIR). and lozenges. Such oral hygiene compositions may com 0281 Such bioactive glass compositions may comprise prise between 0.1 to 50% by weight. Formulations compris particles having a particle size of about 20 microns with ing 1 to 25% by weight are preferable, while formulations about 30 percent of the particles less than 10 microns. Other comprising 5 to 10% by weight of the bioactive glass are formulations may comprise bioactive glass particles have an even more preferable. average particle size of 10 microns with at least 25% smaller 0289. In addition to the active ingredients, suitable oral than 2 microns. hygiene compositions may contain the usual carriers, bind 0282. These compositions may be formulated into tooth ers, Surfactants, humectants, coloring agents, pigments, anti paste. In fact, the particles may replace the silica currently plaque agents, anti-bacterial agents, bioadhesive-type used in toothpastes. The addition of fluoride in the glass agents, abrasives, anticaries agents, flavorings, Sweeteners, composition will enhance and strengthen the tooth structure. bulking agents, and the like. In addition to direct application of the bioactive glass to the 0290. In the case of a toothpaste formulation, an abrasive teeth, these bioactive glass compositions may also be typically includes amorphous, gelled, precipitated, or fumed applied in a saline or distilled water based medium. These silica, plastics particles, alumina, calcium carbonate, and compositions may also be formulated into mouthwash, gel Zinc orthophosphate, insoluble metaphosphates and calcium or they may be applied by a dentist as a paste. pyrophosphate. Silica is an especially Suitable abrasive. The 0283 These compositions can be used in methods for bioactive glass particles may replace all, Some, or none of whitening, lightening or bleaching teeth. These methods are the abrasive currently used in toothpastes. also useful for removing stains from teeth. These methods 0291 Inorganic thickeners may be included in the den include contacting teeth with an effective tooth-whitening tifrice's and further include fumed silicas such as Cabosil amount of bioactive glass, especially methods using mul available from Cabot Corporation, and thickening silicas tiple applications. Each application may include between including those available from J. M. Huber designated about 0.02 to 0.3 grams of bioactive glass. Suitably, these Zeodent 165. Organic thickeners such as natural and Syn methods of whitening teeth comprise contacting the teeth thetic gums and colloids may also be incorporated in den with an effective tooth-whitening amount of bioactive glass tifrice compositions. Examples of Such thickeners include twice daily for two weeks or more. “Tooth-whitening carrageenan (Irish moss), Xanthan gum and Sodium car amount generally refers to any amount that will result in a boxymethyl cellulose, starch, polyvinlpyrrolidone, hydroxy Vita shade guide lightening of one or more shades in a ethyl propyl cellulose, hydroxbutyl methyl cellulose, patient with a pre-treatment shade darker than A3.5 after 4 hydroxypropyl methyl cellulose, and hydroxyethyl cellulose weeks of application twice daily for two minutes or more per (co-dried blends of microcrystalline celluloselcellulose application. gum). The inorganic or organic thickener may be incorpo 0284 Methods for whitening teeth may also comprise rated in such compositions at a concentration of about 0.05 contacting teeth with an effective tooth-whitening amount of to about 2% by weight and preferably about 0.1 to about particulate bioactive and biocompatible glass comprising 1.5% by weight. silicon oxide or hydroxide and optionally one or more 0292 Fluoride-providing salts having anti-caries efficacy elements such as Na, K, Ca, Mg, B, Ti, Al, P N or F. may also be incorporated in the oral compositions and are 0285) Such bioactive glass compositions usually com characterized by their ability to release fluoride ions in prises at least Na, Ca and P. although it is possible to use water. It is preferable to employ a water-soluble salt fluoride simple Sodium silica glasses together with external sources providing about 10 to 5,000 ppm of fluoride ion and pref of calcium and phosphate. An external source of calcium and erably about 1000 to 1500 ppm of fluoride ion. Among these US 2007/0275021 A1 Nov. 29, 2007 29 materials are water-soluble alkali metal salts, for example, 0299 Common formulations of mouthwash and mouth Sodium fluoride, potassium fluoride, Sodium monofluoro rinse products comprise thymol, eucaluptol, methyl salicy phosphate and sodium fluorosilicate. Sodium monofluoro late menthol, water, alcohol, benzoic acid, poloxamer 407, phosphate is a preferred fluoride-providing salt. Sodium benzoate, and caramel. 0293 Pigments may include non-toxic, water insoluble 0300 Mouthwash and mouth rinse products may also inorganic pigments such as titanium dioxide and chromium include one or more of the following: aloe Vera, calcium oxide greens, ultramarine blues and pinks and ferric oxides chloride, calcium lactate, cetylpyridinium chloride, citric as well as water insoluble dye lakes prepared by extending acid, domiphen bromide, glucono delta lactone, glucose calcium or aluminum salts of FD&C dyes on alumina Such oxidase, glycerin, hydrogenated Starch, hydroxyethylcellu as FD&C Green #1 lake, FD&C Blue #2 lake, FD&C R&D lose, lactoferrin, lactoperoxidase, lysozyme, magnesium #30 lake and FD&C Yellow #15 lake. The pigments have a chloride, methylparaben, natural and artificial flavorings, particle size in the range of 5-1000 microns, preferably nitrogen, poloxamer 237, polysorbate 20, polysorbate 80, 250-500 microns, and are present at a concentration of 0.5 potassium chloride, potassium phosphate, povidone-iodine, to 3% by weight. Dyes are generally sensitive to the pres propylene glycol, Saccharin, saccharin Sodium, SD alcohol ence of the peroxide ingredient and are not included in the 38-B, sodium carboxymethylcellolose, sodium chloride, dentifrice although FD&C Green #3 has been found to be Sodium citrate, Sodium gluconate, sodium hydroxide, resistant to fading when CaO2 is present in the dentifrice. Sodium lauryl Sulfate, sodium saccharin, Sorbitol, Sodium 0294 Any suitable flavoring or sweetening material may pyrophosphate, various natural and artificial flavorings, Xan be employed. Examples of Suitable flavoring ingredients are than gum, Xylitol, Zinc chloride and Zinc oxide. flavoring oils, e.g., oils of spearmint, peppermint, winter 0301 The present invention provides for novel formula green, Sassafras, clove, Sage, eucalyptus, marjoram, cinna tions of mouthwash and mouth rinse products by incorpo mon, lemon, and orange, and methyl salicylate. Suitable rating bioactive glass into a combination of any of the Sweetening agents include Sucrose, lactose, maltose, Sorbi above-listed ingredients. tol, Sodium cyclamate, perillartine, and Sodium saccharin. Suitably, flavor and Sweetening agents may together com 0302) In addition to direct application of the bioactive prise from 0.01% to 5% or more of the preparations. glass to the teeth, these bioactive glass compositions can also be applied in a saline or distilled water based medium. 0295 Various other materials may be incorporated into these oral compositions. For example, preservatives, sili 0303) These oral formulations may be used together with cones and chlorophyll compounds, vitamins such as Vita a source of calcium and/or phosphate in the manufacture of mins B6, B12, C, E and K, antibacterial agents such as a composition for whitening teeth. chlorhexidine, halogenated diphenyl ethers such as tri 0304. The antimicrobial and abrasive effects of bioactive closan, desensitizing agents such as potassium nitrate and glass are particularly useful in mouthwash and mouth rinse potassium citrate and mixtures thereof may be included. products to reduce bacteria and to remove stains. These adjuvants are incorporated in the dentifrice in amounts which do not substantially adversely affect the Eye Drop Products properties and characteristics desired, and are selected and 0305 The present invention includes novel formulations used in properamounts, depending upon the particular type which incorporate bioactive glass into various brands of eye of component involved. drop products such as the products marketed under the 0296. The making of gels, toothpastes, rinses, mouth brand names Medic's Choice, Alcon, All Clear, Baush & washes, gums, and chewing gums are well known in the art. Lomb, Bio, Tears Naturale, Clear Eyes, Murine Plus, Naph Bioactive glasses can be introduced into these products by a con, OcuClear, Opcon-A, Prefrin, Vasoclear, Visine, and variety of methods including simple mixing. In some cir products produced by high-end and generic manufacturers. cumstances it will be necessary to keep the bioactive glass 0306 Generally, eye drop products comprise polyethyl from coming into contact with the aqueous or other com ponents of the delivery vehicle to prevent the bioactive glass ene glycol 300, naphazoline hydrochloride and benzalko from pre-reacting. This can be accomplished in a number of nium chloride. ways including, for example, two piece Syringes with a 0307 Eyedrop products may also include one of the mixing chamber. following: boric acid, edetate disodium, water, sodium borate, polyvinyl alcohol, povidone, tetrahydrozoline hydro Mouthwash and Mouth Rinse Products chloride, dextrose, disodium EDTA, potassium chloride, 0297. The present invention includes novel formulations water, Sodium bicarbonate, sodium chloride, sodium citrate, which incorporate bioactive glass into various brands of Sodium phosphate, oxymetazoline HCl, hydroxpropyl mouthwash and mouth rinse products such as the products methyl cellulose, pheniramine maleate, liquifilm, phenyle marketed under the brand names Act, Doctor Tichenor, phrine HCl, sodium acetate, sodium thiosulfate and hydro Glyoxide Antiseptic, Betadine, Biotene, Cepacol, Colgate, chloric acid. Good Sense, Lavoris, Listerine, Listermint, Plax, Reach, Rembrandt, Salivart, Scope, Signal, Targon, Tom's of 0308 The present invention provides for novel formula Maine, Viadent, Vince, Weleda, and products produced by tions of eye drop products by incorporating bioactive glass high-end and generic manufacturers. into a combination of any of the above-listed ingredients. 0298 Generally, mouthwash and mouth rinse products Contact Lens Treatment Products comprise fluoride, antibacterial agents, hydrogen peroxide 0309 Bioactive glass may also be incorporated into vari and Sodium carbonate. ous brands of contact lens treatment products, including US 2007/0275021 A1 Nov. 29, 2007 30 cleaning solutions for hard and Soft lens, saline Solutions, 2. A shampoo product, containing 5 wt % of 4 um bioactive and rewetting Solutions, such as the products marketed glass formulated in a combination of Standapol ES-2, Cro under the brand names Alcon, Allergan, Barnes Hind, Sultaine C-50, Foamid C. deionized H0, Phenobact and Bausch & Lomb, Boston, Ciba, Clean-N-Soak, Clerz Z. citric acid. Liquifilm, Opti-Soak, ProFree, Resolve, Soac-Lens, Wet-N- Soak, Alcon, Allergan, Ciba Vision, Complete, Lens Plus, 3. A nail-hardening/protecting gel, containing gelled jojoba Miraflow, Opti-Clean, Opti-Free, Opti-Zyme, Pliagel, oil or glycerin and a PemulenR polymer, or glycerin, water, ReNu, Sensitive Eyes, Ultra Zyme, drugstore.com, Soft citric acid, Jaguar C-14S and phenobact. wear, Unisol, Clear Eyes, ClerZ Z, Opti-One, and products 4. Makeup formulas, containing gelled jojoba oil and with produced by high-end and generic manufacturers. Lubrajel(R) MS with various pigments 0310 Generally, contact lens treatment products com 5. A skin lotion/makeup, containing Polawax, mineral oil, prise boric acid, Sodium chloride, thimersol, and edetate glycerin, Jaguar C14-S, citric acid, Phenobact, colorant and disodium. fragrance 0311 Contact lens treatment products may also include 6. A Sunscreen product, containing gelled jojoba oil, octyl one or more of the following: benzalkonium chloride, alkyl methoxycinnamate and benzophenone-3 ether Sulfate, ethoxylated alkyl phenol, tri-quaternary cocoa based phospholipid, silica gel, titanium dioxide, fragrance, 7. A deodorant stick containing 8% bioactive glass and phenylmercuric nitrate, polyvinyl alcohol, anionic deter composition MV00/036/02/01 gents, sodium phosphates, polysorbate 80, hydroxyethyl 8. A deodorant stick containing 8% bioactive glass and cellulose, polycuad, papain, cocoamphocarboxyglycinate, composition MV00/036/01/01 Sodium lauryl Sulfate, hexylene glycol, pancreatin, tylox apol, Sorbic acid, Subitilisin A, poloxame 407, amphoteric 9. A deodorant stick containing 5% bioactive glass and 10, tween 21 stabilizer, microclens, potassium chloride, composition MV00/030/02/01 proteolytic enzyme, Sodium carbonate, poloxamine, sodium 10. A deodorant cream containing 50% bioactive glass and borate, isotonic saline, antimicrobial buffer system, sodium perborate, hydrogen peroxide, phosphonic acid, nitrogen, composition MV00/036/03/01 borate buffer system, water, EDTA, caramide, glycerin, and 11. A nail hardening creme containing 15% bioactive glass povidine. and composition MV00/036/04/01A. 0312. In addition, bioactive glass may be added to or 12. A nail hardening creme containing 30% bioactive glass included in ear drops and nose drops to provide or enhance and composition MV00/036/04/01B anti-bacterial, anti-inflammatory, and hygroscopic effects. 03.19 Example 15 below demonstrates that the cosmetic 0313 Bioactive glass also may be added to or incorpo formulations comprising bioactive glass, including Sol-gel rated into nail files, e.g., fingernail and toenail files. The derived bioactive glass, do not irritate the skin or result in anti-inflammatory properties of bioactive glass make it any perceivable allergic hypesensitivity. particularly well-suited for use with such nail care devices. EXAMPLE 1.5 0314. In addition, bioactive glass may be used with men's or women's shaving devices, including but not lim Skin Sensitivity Tests ited to disposable and electric razors. The antibacterial and anti-inflammatory properties of bioactive glass make it 0320 Several prototype products (Bioglass (30% utl.) in well-suited for use in Such products. an O/W-Formulation) were tested to determine if skin irri tation or allergic hypersensitivity was present following the 0315 Bioactive glass may also be added to or included in oral care products Such as Ambisol. The anti-inflammatory use of any of the protypte cosmetic compositions comprising and antimicrobial properties of bioactive glass can be ben bioactive glass. eficial in Such products. 0321) Patch testing represents a sound, relatively safe and reasonable reliable method for identifying allergens. A posi 0316 Example 14 below provides exemplary embodi tive reaction to a correctly applied patch-test proves that the ments of additional prototype cosmetic formulations incor person has a contact sensitivity to the Substance tested, but porating bioactive glass, including sol-gel-derived bioactive not necessarily that the Substance is the cause of the clinical glass. dermatitis. EXAMPLE 1.4 0322. In patch testing, the suspected topical allergen has to penetrate the stratum corneum to the viable (effector) cells Additional Protype Cosmetic Formulations of the skin to present a local challenge to the immune system. 0317 Several prototype cosmetic products comprising 0323 Methods: The product to be tested is applied on a bioactive glass were developed as follows. patch of filter paper, placed on an impermeable sheet and 0318 1. A soft focus cosmetic product was developed fixed to the skin with adhesive tape (Leukotest(R), Fa. Hart and comprised a sol-gel-derived bioactive glass powder mann). Test site: inner side of the forearm. The test patch is mixed with a commercially available facial cream. This left in place for 24 hours then removed. The examination by product gave the appearance of wrinkle reduction and skin the dermatologist follows. A second and third examination tightening when applied to the face. are performed after 48 and 72 hours by the dermatologist. US 2007/0275021 A1 Nov. 29, 2007 31

0324 All assessments were performed under standard 0336) lighting conditions by the responsible dermatologist. 0325 Panellists were instructed to keep the test sites dry over the application period. Test organism Batch No. 0326 Results: Under the conditions of this test no evi- Pseudomonas aeruginosa 1 2 3 dence of primary irritation or allergic hyperSensitivity was present. None of the thirty patch-tests resulted in positive 1 day 4 4 3 reactions after 24, 48 and 72 hours. The tested products are : t : : i considered safe for use. 5 days 2 O O 0327 Examples 16 and 17 below provide the results of inhibition Zone tests and demonstrates the anti-microbial effects of bioactive glass. The anti-microbial effects of 0337 bioactive glass are useful in many of the cosmetic formu lations described above. EXAMPLE 16 Test organism Batch No. Candida albicans 1 2 3 Inhibition Zone Test 1 day 3 3 3 0328 Liquid Caso agar or Sabouraud agar was mixed 2 days O 1 1 with the corresponding test organism (target: 10 CFU/plate) t g g g and poured into petri dishes. After the agar had cooled, a disk (approx. 1 cm in diameter) was punched out of the agar and was filled with approximately 0.5 g 45S (BioaglassTM) 0338) bioactive glass powder. The agar was stored for 2 hours at 5° C. and subsequently incubated. After completion of the incubation period (1-5 days), the samples were checked for inhibition Zone formation and growth. Test organism Batch No. The test organisms used were: Aspergilius niger 1 2 3 0329 Bacillus subtilis ATCC 6633 1 day 5 5 5 2 days 5 5 4 0330 Staphylococcus aureus ATCC 6538 3 days 3 3 2 5 days 2 2 O 0331) Pseudomonas aeruginosa ATCC 9027 0332 Candida albicans ATCC 10231 0339 pH controls on nutrient media without seeding with 0333 Aspergillus niger ATCC 16404 microorganisms, but in the presence of the sample resulted Results: in the following: 0334) Size of Inhibition Zone in mm Per Sample Batch on glass powder: pH >= 10 on agar near glass powder pH 9.5 on agar (periphery): pH 8.5 Test organism - Batch No- (control plate without glass powder: pH 7.5) Bacilius subtiis 1 2 3 1 da 5 5 3 ity, 2 2 1 EXAMPLE 17 3 days 2 1 1 5 days 2 O O Concentration Dependent Inhibition Test 0340 Liquid Caso agar or Sabouraud agar was mixed 0335) with the corresponding test organism (target: 10 CFU/plate) as well as variable amounts (see chart below) of 45S bioactive glass powder and poured into petri dishes. The agar was stored for 2 hours at 5° C. and Subsequently Test organism Batch No. incubated. After completion of the incubation period (1-5 Staphylococcusatiretts 1 2 3 days) the samples were checked for inhibition Zone forma tion and growth. 1 day 4 4 4 2 days 3 3 2 The test organisms used were: 3 days 3 3 2 5 days 3 2 2 0341 Bacillus subtilis ATCC 6633 0342 Staphylococcus aureus ATCC 6538 US 2007/0275021 A1 Nov. 29, 2007 32

0343 Pseudomonas aeruginosa ATCC 9027 -continued 0344 Candida albicans ATCC 10231 0345 Aspergillus niger ATCC 16404 Test organism Content of glass in Ing Aspergilius niger 10 100 2OO 500 1OOO 0346 Results: Organism count using different amounts of glass powder 3 days >10 -300 >30 O O 5 days >10 ------+ = growth detectable after subcultivation - = no growth detectable after subcultivation Test organism Content of glass in Ing n.d. = not performed

Bacilius subtiis 10 100 2OO 500 1OOO 0351. The antimicrobial effect of bioactive glass could be 1 day >10 >10 >10 O O detected both in the inhibition Zone test as shown in 2 days >10 >10 -10° O O 3 days >10 >10 -10° O O Example 16 and as a function of concentration as shown in 5 days >10 >10 -- Example 17. 0352. The reduction in microbial growth correlates with 0347) a pH increase in the medium. 0353 Examples 18 and 19 below demonstrate the effect of bioactive glass on a variety of microorganisms. Test organism Staphylococcits Content of glass in Ing EXAMPLE 1.8 (iiietS 10 100 2OO 500 1OOO Microbiological Test Series 1 day >10 >10 -10 O O 2 days >10 >10 >10 O O 0354 Microbiological test series with individual micro 3 days >10 >10 -10 O O organisms of an aqueous Solution of bioactive glass (clear 5 days >10 >10 -- supernatant), O/W emulsion, W/O emulsion each with dif ferent concentrations of bioactive glass. 0348 Conditions: 0355) Individual microorganism suspension Test organism 0356) With common salt (in the aqueous solution) Pseudomonas Content of glass Ing 0357) pH value unchanged aeruginosa 10 100 2in OO 500 1OOO Non-sterilized aqueous solution 1 day >10 >10 -10° O O 0358) 2 days >10 >10 -10° O O Arrangement: 3 days >10 >10 -10° O O 5 days >10 >10 -- 0359 Overview tables of load test of individual micro organisms 0349) 0360 Test formulas V99/020/01/11-19 (aqueous Supernatant) 0361 Test formulas V99/020/02/01a-h (O/W emul Test organism Content of glass in Ing sion) (a-h=different concentrations BioGlas/none to 0.2% VSM12650) Candida albicans 10 100 2OO 500 1OOO 1 day >10 >10 O O O 0362 Test formulas V99/020/02/02a-f (O/W emul 2 days >10 >10 -300 O O sion) (a-f=different concentrations BioGlas/none to 3 days >10 >10 -300 O O 20% VSM12650) 5 days >10 >10 ------0363 Test formulas V99/020/03/01a-h (W/O emul sion) (a-h=different concentration BioGlas/none to 0350 0.2% VSM12650) 0364 Test formulas V99/020/03/02a-f (W/O emul Test organism Content of glass in Ing sion) (a-f=different concentration BioGlas/none to 20% Aspergilius niger 10 100 2OO 500 1OOO VSM12650) 1 day n.d. n.d. n.d. n.d. n.d. 0365 Load test MB990669-713 (aqueous supernatant) 2 days >10 >300 >30 O O 0366 Load test MB990714-743 (O/W emulsion) US 2007/0275021 A1 Nov. 29, 2007 33

0367) Load test MB990744-773 (W/O emulsion) O/W Emulsion/W/O Emulsion Stability test S990029 (for V99/020/02/01h) 0375 Even at lower concentrations of bioactive glass 0368 (2%), a clear preservative effect is observed. But here, too, 0369) Stability test S990046 (for V99/020/02/02e) Aspergillus niger exhibits the behavior described above. Stability 0370) Stability test S990030 (for V99/020/03/01h) S990O29-OFW emulsion base V99/020/02/01 h-0.2% 0371) Stability test S990047 (for V99/020/03/02e) VSM12650 Results: Normal test: -7°C./40° C.; stable Aqueous Supernatent Extreme test: = 14° C./60° C.; separation in 3rd cycle emulsion base 0372 Except for Aspergillus niger, all load tests show a logical course of the test series. Normal test: stable 0373). From a concentration of between 3% and 5% of Extreme test: stable bioactive glass, no growth is detectable even after 6 load cycles. Bioactive glass is most effective against Staphyllo S990O3O-WFO emulsion base V99/020/03/01 h-0.2% COCCS CaliS. VSM12650 0374. Aspergillus niger, starting from the 4th load cycle, Normal test: separation after 3rd cycle no longer shows any growth inhibition. Bioactive glass is Extreme test: n/a effective against Aspergillus niger at higher concentrations up to the 4th load cycle. (Note: this result is not surprising S990O47 WFO emulsion base V99/020/03/02e=20% since Aspergillus niger, compared to other species, fre VSM12650 quently presents a problem with other preservation systems 0376 Separation of emulsion even before the start of the as well.) test series.

LOAD TEST with BIOGLAS ASPERGILLUS NIGER Test Series 3A V99/020/01/11-V99/020/01/19 Aqueous Solution/Supernatant V99,020 O2/O2 OW Emulsion V99,02003/02 WO Emulsion Concentration Cycle O Cycle 1 Cycle 2 Cycle 3 Cycle 4 Cycle 5 Cycle 6 Aqueous Solution (Supernatant without Sediment) (V99/020/01/11-19)

O.S90 ------+++ Explanation: O.8% ------+++ Cycle 0: Smear without 196 ------+++ inoculation 296 ------+++ Cycles 1-6: inoculated 3% ------+++ with above species 59 ------+++ Concentration in Sample 10% ------+++ container; ca. 10 15% ------20% ------OW Emulsion (V99/020/02/02)

296 ------+++ Explanation: 59 -- -- Cycle 0: Smear without 10% inoculation 15% ------++ Cycles 1-6: inoculated 20% ------++ with above species Blank test ------+++ Concentration in Sample container; ca. 10 Blank test: without BioGlas W/O Emulsion (V99/020/03/02)

296 ------+++ Explanation: 59 ------Cycle 0: Smear without 10% ------inoculation 15% Cycles 1-6: inoculated 20% with above species Blank test ------+++ Concentration in Sample container: ca. 10 Blank test: without BioGlas US 2007/0275021 A1 Nov. 29, 2007 34

0377)

RESULTS OF LOAD TEST with BIOGLAS CANDIDA ALBICANS Test Series 3B V99/020/01/11-V99/020/01/19 Aqueous Solution/Supernatant V99,020 O2/O2 OW Emulsion V99,02003/02 WO Emulsion Concentration Cycle O Cycle 1 Cycle 2 Cycle 3 Cycle 4 Cycle 5 Cycle 6 Aqueous Solution (Supernatant without Sediment) (V99/020/01/11-19)

O.S9/o ------+++ Explanation: O.8% ------+++ Cycle 0: Smear without 190 ------+++ inoculation 2% ---- +++ Cycles 1-6: inoculated 3% with above species 59% Concentration in Sample 10% container: ca. 10 15% 20%

2% Explanation: 59% Cycle 0: Smear without 10% inoculation 15% Cycles 1-6: inoculated 20% with above species Blank test ------+++ Concentration in Sample container: ca. 10 Blank test: without BioGlas W/O Emulsion (V99/020/03/02)

2% ------+++ Explanation: 59% -- Cycle 0: Smear without 10% inoculation 15% Cycles 1-6: inoculated 20% with above species Blank test ------+++ Concentration in Sample container: ca. 10 Blank test: without BioGlas

0378)

LOAD TEST with BIOGLAS ESCHERICHLA COLI Test Series 3C V99/020/01/11-V99/020/01/19 Aqueous Solution/Supernatant V99,020 O2/O2 OW Emulsion V99,02003/02 WO Emulsion

Concentration Cycle O Cycle 1 Cycle 2 Cycle 3 Cycle 4 Cycle 5 Cycle 6 Aqueous Solution (Supernatant without Sediment) (V99/020/01/11-19)

O.S9/o ------+++ Explanation: O.8% -- Cycle 0: Smear without 190 ------+++ inoculation 2% +++ Cycles 1-6: 3% inoculated with above 59% species 10% Concentration in 15% - Sample container: ca. 20% - 106 US 2007/0275021 A1 Nov. 29, 2007 35

-continued

LOAD TEST with BIOGLAS ESCHERICHLA COLI Test Series 3C V99/020/01/11-V99/020/01/19 Aqueous Solution/Supernatant V99,020 O2/O2 OW Emulsion V99,02003/02 WO Emulsion Concentration Cycle O Cycle 1 Cycle 2 Cycle 3 Cycle 4 Cycle 5 Cycle 6 OW Emulsion (V99/020/02/02) 2% - Explanation: 59% Cycle 0: Smear without 10% (+) - inoculation 15% Cycles 1-6: 20% inoculated with above Blank test species Concentration in sample container: ca. 106 Blank test: without BioGlas W/O Emulsion (V99/020/03/02) 2% -- (+) (++) (++) Explanation: 59% Cycle 0: Smear without 10% inoculation 15% Cycles 1-6: 20% inoculated with above Blank test ++ species Concentration in sample container: ca. 106 Blank test: without BioGlas (+), (++): contamination with foreign microorganisms

0379)

LOAD TEST with BIOGLAS PSEUDOMONAS AERUGINOSA Test Series 3D V99/020/01/11-V99/020/01/19 Aqueous Solution/Supernatant V99,020 O2/O2 OW Emulsion V99,02003/02 WO Emulsion Concentration Cycle O Cycle 1 Cycle 2 Cycle 3 Cycle 4 Cycle 5 Cycle 6 Aqueous Solution (Supernatant without Sediment) (V99/020/01/11-19) O.S9/o ------+++ Explanation: O.8% ------+++ Cycle 0: Smear without 190 ------+++ inoculation 2% ------+++ Cycles 1-6: inoculated 3% ------+++ with above species 59% -- Concentration in Sample 10% container; ca. 10 15% 20% OW Emulsion (V99/020/02/02) 2% Explanation: 59% Cycle 0: Smear without 10% inoculation 15% Cycles 1-6: inoculated 20% with above species Blank test Concentration in Sample container: ca. 10 Blank test: without BioGlas US 2007/0275021 A1 Nov. 29, 2007 36

-continued

LOAD TEST with BIOGLAS PSEUDOMONAS AERUGINOSA Test Series 3D V99/020/01/11-V99/020/01/19 Aqueous Solution/Supernatant V99,020 O2/O2 OW Emulsion V99,02003/02 WO Emulsion Concentration Cycle O Cycle 1 Cycle 2 Cycle 3 Cycle 4 Cycle 5 Cycle 6 W/O Emulsion (V99/020/03/02)

2% ------+++ Explanation: 59% Cycle 0: Smear without 10% inoculation 15% Cycles 1-6: inoculated 20% with above species Blank test ------+++ Concentration in Sample container: ca. 10 Blank test: without BioGlas

EXAMPLE 19 0392 4. High pH value correlates with microorganism inhibition. Microbiological Test Series 0380 Microbiological Test Series with individual micro organisms of selected O/W emulsion (V99/020/04/03 (G4)= Load Test with Bioglas new laboratory sample V99/020/06/01) Test Series 7A Aspergillus niger Candida albicans Conditions: V99/020/06/01 O/W Emulsion (Dragil) non-sterilepH non-adjusted 0381 individual microorganism suspension Product Test Number Prod. date Test start NE OFW Crean W99,020.06.01 Oct. 11, 1999 Oct. 15, 1999 0382 pH value changed to values typical in cosmetics (Dragil) (citric acid) A. niger 10 CFU/ml 0383 non-sterilized pH Value Cons. No. before Arrangement: MB99 Bioglas % Blank Cycle 1 Cycle 2 Cycle 3 start of test

0384 overview table of load test of individual micro 1000 a)2 ------10.9 organisms 1001 b) 5 11.6 1002 c) 10 11.8 0385 overview table of pH adjustment and change 1003 d) 15 12.1 over time 1004 e) 20 12.2 1005 f) none ------7.1 0386 test formulas V.99/020/06/O la-f C. albicans 10 CFU/ml 0387 load test MB991000-1034 pH Value Cons. No. before Results/Conclusions: MB99 Bioglas % Blank Cycle 1 Cycle 2 Cycle 3 start of test 0388 Although, microorganism sterility with O/W emul 1006 a)2 10.9 sions is difficult to achieve the first smear (blank) shows 1007 b) 5 11.6 sterility except for E. coli. In addition, despite selecting a 1008 c) 10 (+++P) - 11.8 suitable O/W emulsion base this base has its own preserva 1009 d) 15 12.1 tive effect against E. coli and Staphylococcus aureus. 1010 e) 20 12.2 1011 f) none ------7.1 The results from Example 19 indicate: 0389) 1. The pH value of the O/W base increases again in the course of the test series to the values before 0393) adjustment with citric acid. The pH value of the sample without bioactive glass remains unchanged. Load Test with Bioglas 0390 2. Microorganism growth is clearly inhibited. Test Series 7B Escherichia coli Pseudomonas aeruginosa 0391) 3 With hight concentrations even a difficult to V99/020/06/01 OW Emulsion (Dragil) control organism such as Aspergillus niger is effec non-sterilepH non-adjusted tively inhibited. US 2007/0275021 A1 Nov. 29, 2007 37

invention also provides methods of making and using these -continued novel non-toxic cleaning agents. Product Test Number Prod. date Test start 0396 Particulate bioactive glass and/or aqueous extracts NE OFW Crean W99,020.06.01 Oct. 11, 1999 Oct. 15, 1999 of particulate bioactive glass can be added to standard (Dragil) household cleaning agents as well as industrial cleaning agents. The resulting formulations provide cleaning agents E. coli 10 CFU/ml with enhanced cleaning and anti-microbial properties. In pH Value addition to the direct anti-microbial effects of bioactive Cons. No. before glass, the increased pH resulting from the presence of MB99 Bioglas % Blank Cycle 1 Cycle 2 Cycle 3 start of test bioactive glass also enhances cleaning. In addition, bioactive 1012 a)2 10.9 glass has a high affinity for proteinaceous matter, such as 1013 b) 5 11.6 blood and food as well as oil and grease. Cleaning agents 1014 c) 10 11.8 containing bioactive glass may be used to effectively clean 1015 d) 15 12.1 1016 e) 20 12.2 and disinfect Surfaces including, but not limited to painted 1017 f) none ------7.1 walls, wood furniture, vinyl floors (waxable and nonwax), vitreus china, porcelain enamel, stainless steel, plastic lami Ps, aeruginosa 107 CFU/ml nate (FormicaR), plastic, acrylic, fiberglass, and chrome. pH Value These new cleaning agents may also be used to effectively Cons. No. before clean textile materials, including but not limited to, rugs MB99 Bioglas % Blank Cycle 1 Cycle 2 Cycle 3 start of test woven from wool, various synthetic fibers, and articles of clothing. 1018 a) 2 10.9 1019 b) 5 11.6 0397. A traditional cleaning agent may be, for example, 102O c) 10 11.8 a compound containing one or more surfactants useful for 1021 d) 15 12.1 dissolving dirt in a solvent, especially in an aqueous solvent. 1022 e) 20 12.2 Surfactants are generally effective in cleaning grease or oily 1023 f) none ------7.1 dirt. However, other dirt, such as proteins or dirt containing proteins, e.g., blood, other staining Substances such as coffee 0394) or tea, as well as invisible dirt, including dirt from micro organisms, cannot be cleaned in this way alone. For this reason a bleaching agent and/or disinfecting agent are usu ally added to the cleaning formulations, so that the remain Load Test with Bioglas Test Series 7C ing dirt is at least removed to the point that it is no longer Staphylococcus aureus Escherichia coli (pH adjusted) visible. Stains are usually removed oxidatively after the V99/020/06/01 OW Emulsion (Dragil) grease and pigment dirt is dissolved. non-sterilepH non-adjusted Product Test Number Prod. date Test start 0398. Oxidative removal is generally accomplished, for NE OFW Crean W99,020.06.01 Oct. 11, 1999 Oct. 15, 1999 example, with chlorine-containing chemicals. Chlorine-con (Dragil) taining chemicals generally remove only the coloring part of the stain, whereas the other indissoluble substances remain St. aureus 107 CFU/ml with the basic substance. Because of its high reactivity, the pH Value disadvantage of chlorine is that it aggressively attacks Cons. No. before colored Surfaces or Substances such as fabrics changing the MB99 Bioglas % Blank Cycle 1 Cycle 2 Cycle 3 start of test color tone or causing the colors to bleed. In addition, 1024 a)2 10.9 chlorine aggressively attacks the Substance to be cleaned, 1025 b) 5 11.6 especially fabrics, so that their basic structure is destroyed 1026 c) 10 11.8 after multiple washings. 1027 d) 15 12.1 0399 Previous attempts to alleviate the oxidizing effect 1028 e) 20 12.2 of chlorine involved the use per-acetic acid. Although per 1029 f) none ------7.1 acetic acid has an adequate disinfecting effect, its ability to E. coli 10 CFU/ml (control measurement with adjusted pH value) penetrate porous material is insufficient, which in turn leads pH Value to an unsatisfactory sterilization effect. In addition, per Cons. No. Now. acetic acid has an oxidizing effect, although to a smaller MB99 Bioglas % Blank Cycle 1 Cycle 2 Cycle 3 O9, 1999 degree. Although the oxidizing effect of per acetic acid may not create a color-destroying bleaching effect, in most cases 1030 a)2 ------8.5 1031 b) 5 10 its disinfecting effect is not sufficient. For this reason is not 1032 c) 10 ---- 10 possible, for example, to remove aerobic spore producers. 1033 d) 15 10 Furthermore, the use of per-acids results in significant 1034 e) 20 10 damage to some materials, such as woolens. 0400. Accordingly, a goal of one embodiment of present Cleaning Agents invention is to produce cleaning agents which are non-toxic, yet provide an antimicrobial effect, while also providing General good cleaning qualities. 0395. The present invention provides novel cleaning 04.01 Since bioactive glass releases Ca" ions, it was agent compositions comprising bioactive glass. The present expected that the presence of bioactive glass in an aqueous US 2007/0275021 A1 Nov. 29, 2007

Solution would significantly increase the hardness of the 0408. In one embodiment the cleaning agent containing solution. It was therefore expected that calcification would bioactive glass releases more than 250 lug of alkaline ions increase resulting in a reduction of cleaning action, so that per gram of glass particles. The glass particles contained in these glasses would not be suitable for use as washing and the cleaning agent according to another embodiment of the cleaning agents. Moreover, it was expected that the abrasive present invention preferably release more than 300 g, and effect of glass particles would result in a mechanical damage especially more than 500 ug of alkaline ions per gram of of materials, especially in textiles, which would lead to a glass particles. Glass particles that release more than 1 mg corrosion of the fabric. Nevertheless, applicants unexpect of alkaline ions per gram of glass are even more especially edly found that a variety of effective cleaning agents could preferred. be formulated comprising bioactive glass. Surprisingly, the effectiveness of the washing agent is not hindered by the 04.09 Such cleaning agents are not only useful for clean release of alkaline ions and there is no increase in the ing and sterilizing Surfaces and textile materials but also may be used to clean and sterilize Surgical instruments. In hardness of the water or calcification. Also, these novel addition, cleaning agents containing bioactive glass are cleaning agents do not corrode or damage the materials useful as dish washing agents, especially for use in dish being cleaned, especially textile fabrics, as feared through washers. These novel cleaning agents may also be used in the addition of the glass particles. for disinfecting and cleaning Surfaces and materials in the 0402 Bioactive glass is well-suited as a glass cleaner sanitation, hospital, and gastronomy industries. since it is “softer than standard household cleaners and is suitable as a mild abrasive. In addition, the soluble minerals Methods of Making released by bioactive glass strengthens glass. For example, silicon released by bioactive glass is especially helpful in 0410 The present invention also provides a method of strengthening and protecting glass products by preventing making cleaning agent compositions comprising bioactive glass. An effective antimicrobial amount of the bioactive crack propagation. Bioactive glass coats cracks in glass and glass is added to or included in a cleaning agent formulation. builds up a protective silicon layer. An “effective, antimicrobial amount of bioactive glass” 0403. The present invention also provides a cleaning refers to a Sufficient amount of bioactive glass having an agent containing bioactive glass which not only acts as a appropriate particle size to effectively prevent or control biocide against viruses and bacteria, but is also gentle on microbial contamination. The amount and particle size of skin and materials, causes no allergic reactions and cleans bioactive glass to include in a cleaning agent formulation hard to remove dirt such as set-in proteins. The present will vary depending on the desired length and degree of invention also provides non-toxic cleaning agents having purity as well as the anticipated microbial challenge. An biocidal and dirt removing properties to be used in conjunc “effective antimicrobial amount of bioactive glass' also may tion with a solvent having at least one Surface active agent. refer to a sufficient amount of an aqueous extract of bioac 04.04. In one embodiment the cleaning agent is non-toxic tive glass to effectively prevent or control microbial con and has biocide and dirt-removing features for joint usage tamination. An effective antimicrobial amount of bioactive with a dissolving agent containing at least a surface active glass may also refer to a combination of particulate bioactive agent and contains bioactive glass particles that release more glass and aqueous extract of bioactive glass to effectively than 250 ug of alkaline ions per gram of glass particles. In prevent or control microbial contamination. another embodiment the cleaning agent comprises bioactive glass particles which release at least 300 ug of alkaline ions 0411 Bioactive glass may be added to or included in per gram of glass particles. cleaning agent formulations using, for example, techniques or combinations of techniques such as general mixing with 04.05 The glass particles preferably have an average slow medium, moderate, or even vigorous agitation. Sufi particle size of smaller than 400 m. In another embodiment cient agitation should be provided to achieve relative homo the glass particles have an average particle size of Smaller geneity. Preferably, mixing and agitation will avoid exces than 100 Lum. sive aeration and will have a low sheer rate. Other methods 0406. In one embodiment the cleaning agent comprises or combinations of methods of blending, dispersing, mixing, tenside as a Surface active agent. In another embodiment the combining, and/or emulsifying may be utilized. Agitation cleaning agent contains bioactive glass which has compo may be achieved, for example, with devices such as standard nents within the following ranges on a % weight basis: mixers. General mixing and blending may be achieved, for 40-60% SiO, 10-30% CaO; 0-35% NaO; 2-8% P.O; example, with an impeller. 0-25% CaF: 0-10% B.O.; 0-8% KO; and 0-5% MgO. 0412 Bioactive glass may be added to or included in 0407. In one embodiment the cleaning agent comprises virtually any known cleaning agent formulation. Applicants approximately 1-7% of the weight of glass particles in terms anticipate as well that bioactive glass will be suitable for of the total weight of cleaning agent. In one embodiment the inclusion in any as yet to be developed cleaning agent invention provides a method of making a cleaning agent in formulation. In one embodiment the bioactive glass may be which glass particles are added to at least one Surface active particulate. In another embodiment the bioactive glass may agent, which release at least 250 ug of alkaline ions per gram be an aqueous Solution derived from particulate bioactive of glass particles. In another embodiment the invention glass. In still another embodiment the bioactive glass may be provides a method of using a cleaning agent in clean objects a combination of particulate bioactive glass and an aqueous Such as a variety of Surfaces and textile materials. In one embodiment the cleaning agent is a dish-washing agent. In Solution derived from bioactive glass. another embodiment the invention provides a method of 0413. In one embodiment the method of making these using a cleaning agent for cleaning in hospitals, clinics, and novel cleaning agents comprises combining a cleaning agent in the gastronomy industry. with one or more Surfactants and with bioactive glass. The US 2007/0275021 A1 Nov. 29, 2007 39 method may also include adding a solvent. In one embodi Dish-Washing Products ment the method comprises adding particulate bioactive glass and/or an aqueous extract of bioactive glass. The 0422 The present invention includes novel formulations aqueous Solutions of bioactive glass may be dried, for which incorporate bioactive glass into various brands of example, by spray drying or by drying in vacuo to provide dish-washing products such as the products marketed under an antimicrobial composition. The compositions can be the brand names Ajax. All, Cascade, Crystal White, Dawn, incorporated into other antimicrobial Solutions or cleaning Dove, Earth Friendly, Easy Off, Electrosol, Extra Plus, Glass agents to provide an additional antimicrobial component to Magic, Ivory, Jet Dry, Joy, Palmolive, Sun Light, Surf, and the solutions or cleaning agents. products produced by high-end and generic manufacturers. 0423 Generally, dish-washing products comprise a deter 0414. The present invention will be more clearly under gent, an alkaline compound to increase pH, a Surfactant and stood with reference to the following non-limiting examples. a fragrance. Categories of Cleaners 0424 Common formulations of dish-washing products 0415. The present invention will produce novel formu comprise triclosan, water, ammonium laureth Sulfate, lauryl lations which incorporate bioactive glass into various brands polyglucose, sodium dodecylbenzenesulfonate, SD alcohol of cleaning products including: laundry detergents, stain 3-A, Sodium Xylene Sulfonate, quaternium-15, lauramide removers, and fabric Softening products, dish washing prod myristamide MEA, fragrance and various coloring agents. ucts, air fresheners, deodorizing products, bathroom tissues, 0425 Dish-washing products also may include one or facial tissues, paper towels, napkin products, cotton Swabs, more of the following: chlorine bleach, silicate salts, lauryl handiwipes, Scouring and sponge products, oven cleaning polyglucose, DMDM hydantoin, methylchloroisothiazoli products, toilet cleaning products, tub and shower cleaning none, calcium carbonate, methylisothiazolinone, anionic products, carpet cleaning products, all purpose cleaning surfactants, sodium carbonate, trisodium HEDTA, sodium products, and jewelry and metal cleaning products. metabisulfite, and various quality control agents. Laundry Detergent, Stain Remover and Fabric Softening 0426. The present invention provides for novel formula Products tions of dish-washing products by incorporating bioactive 0416) The present invention includes novel formulations glass into a combination of any of the above-listed ingredi which incorporate bioactive glass into various brands of entS. varieties of laundry detergent, stain remover, and fabric 0427. The antimicrobial and pH effects of bioactive glass softening products, such as the products marketed under the are particularly useful in dish-washing products to reduce brand names Ajax, All, Arm & Hammer, Biz, Bold, Bounce, Carbona, Cheer, Cling Free, Clorox, Dow, Downy, Dreft, bacteria and to increase cleaning power. Dryel, Era, Fab, Febreze, Fresh Start, Gain, Ivory, K2R, Air-Freshener and Room Deodorizing Products Oxydol, Purex, Rit, Shout, Snuggle, Spray & Wash, Stain 0428 The present invention includes novel formulations Devil, Sun Cuddle, Surf, Thoro, Tide, Ultra, Windfresh, which incorporate bioactive glass into various brands of air Wisk, Woolite, ZOut, and products produced by high-end freshener and room deodorizing products such as the prod and generic manufacturers. ucts marketed under the brand names Airwick, Arm & 0417 Generally, laundry detergent, stain remover, and Hammer, Clorex, Country Air, Country Rose, Dale, Enoz, fabric softening products comprise cleaning agents (anionic Glade, Lemon Fresh, LittleTree, Lysol, Moonlight Bay, One and nonionic Surfactants), enzymes, water softener, dispens Drop, Pine Closet, Renuzit, Solid Sachet, Wizard, and ing aid (propylene glycol), buffering agents, water, stabiliz products produced by and high-end and generic manufac ing agents, soil suspending agents, color-protecting agents, turerS. coloring agents and fragrance. 0429 Common formulations of air freshener and room 0418 Common formulations of laundry detergent, stain deodorizing products comprise N-alkyl, dimethyl benzyl remover, and fabric softening products comprise cleaning ammonium chloride, octyl decyl dimethyl ammonium chlo agents (anionic an nonionic Surfactants), buffering agent, ride, dioctyl dimethyl ammonium chloride, and didecyl stabilizer, perfume, brightening agents and coloring agents. dimethyl ammonium chloride. 0419 Laundry detergent, stain remover, and fabric soft 0430 Air freshener and room deodorizing products also ening products may also include one or more of the follow may include one or more of the following: alkyl methyl ing: sodium hypochlorite, hydrogen peroxide, water soften benzyl ammonium saccharinate and ethanol. ers (aluminosilicates, Sodium carbonate), various processing 0431. The present invention provides for novel formula aids (sodium sulfate), various washer protection agents, tions of air freshener and room deodorizing products by various soil suspending agents, cationic Surfactants and incorporating bioactive glass into a combination of any of various preservatives. the above-listed ingredients. 0420. The present invention provides for novel formula tions of laundry detergent, stain remover, and fabric soften 0432. The antimicrobial and pH effects of bioactive glass ing products by incorporating bioactive glass into a combi are particularly useful in air freshener and room deodorizing nation of any of the above-listed ingredients. products to reduce bacteria and odor. 0421. The antimicrobial and pH effects of bioactive glass Bathroom and Kitchen Paper Products are particularly useful in laundry detergent products to 0433. The present invention includes novel formulations reduce bacteria and odor and to increase pH. which incorporate bioactive glass into various brands of US 2007/0275021 A1 Nov. 29, 2007 40 bathroom tissue, facial tissue, paper towel and napkin prod Lime Away, Lysol, Septonic, Sno Bol, Tiolet Duck, Ty-D- ucts Such as the products marketed under the brand names Bol, Vanish, Willert Bowl, and X-14, and products produced Angel Soft, Bounty, Brawny, Brite-Life, Charmin, Cot by high-end and generic manufacturers. tonelle, Good & Plenty, Green Forest, Hi Dri, Kleenex, Marcal, Mardi Gras, Md Bath Tissue, Northern, Puffs, 0445 Generally, toilet cleaning products comprise the Purely Cotton, Scott, Scotties, So-Dri, Soft N Gentle, active ingredient oxacil acid. Sparkle, Vanity Fair, Viva, Wash N Dri, Zee, and products 0446 Common formulations of toilet cleaning products produced by high-end and generic manufacturers. comprise bromine, chlorine, 1-bromo-3-chloro-5,5-dimeth ylhydantoin, 1,3-dichloro-5,5-dimethylhydantoin, and 1,3- 0434 Common formulations of bathroom tissue, facial tissue, paper towel, and napkin products comprise purified dichloro-5-ethyl-5-methylhydantoin. wood pulp, skin conditioners, coloring agents and fragrance. 0447 Toilet cleaning products also may include one or 0435 The present invention provides for novel formula more of the following: hydrogen chloride, alkyl, dimethyl tions of bathroom tissue, facial tissue, paper towel and benzyl ammonium chloride, octyl decyl dimethyl ammo napkin products by incorporating bioactive glass into a nium chloride, didecyl dimethyl ammonium chloride, and combination of any of the above-listed ingredients. dioctyl dimethyl ammonium chloride. 0448. The present invention provides for novel formula Cleaning Accessory Products tions of toilet cleaning products by incorporating bioactive 0436 The present invention includes novel formulations glass into a combination of any of the above-listed ingredi which incorporate bioactive glass into various brands of entS. cotton Swab, handiwipe, Scouring and Sponge products Such as the products marketed under the brand names Arden, 0449 The antimicrobial and pH effects of bioactive glass Ecko, Guardsman, Handi Wipes, Johnson & Johnson, Lysol, are particularly useful in toilet cleaning products to reduce Mr. Clean, O-Cel-O, Pledge, Q-tips, S.O.S., Scotch Brite, bacteria and odor. and products produced by high-end and generic manufac Tub and Shower Cleaning Products turerS. 0450. The present invention includes novel formulations 0437. The present invention provides for novel formula which incorporate bioactive glass into various brands of tub tions of cotton Swab, handiwipe, Scouring and sponge prod and shower cleaning products such as the products marketed ucts by incorporating bioactive glass into a combination of under the brand names Clean Shower, Comet, Dow, Edfred, any of the above-listed ingredients. Lime-Away, Lysol, Parsons, Pine Sol, Scrub Free, Shower 0438. The antimicrobial and pH effects of bioactive glass Power, Soft Scrub, Tilex, X-14, and products produced by are particularly useful in cotton Swab, handiwipe, Scouring high-end and generic manufacturers. and sponge products to reduce bacteria and odor. Addition 0451 Generally, tub and shower cleaning products com ally, the abrasive effects of bioactive glass aid in the removal prise Sodium hypochlorite and/or calcium hypochlorite, a of dirt and stains. detergent and bleach. Oven Cleaning Products 0452 Common formulations of tub and shower cleaning 0439. The present invention includes novel formulations products comprise alkyl, dimethylbenzyl ammonium chlo which incorporate bioactive glass into various brands of rides and detergents. oven cleaning products such as the products marketed under 0453 Tub and shower cleaning products also may the brand names Dow, Easy Off, Kleen King, and products include one or more of the following: dipropylene glycol produced by high-end and generic manufacturers. butyl ether, citric acid, perfume, water, calcium carbonate, Sodium hypochlorite, dimethyl ethylbenzyl ammonium 0440 Generally, oven cleaning products comprise the chlorides, glycol ether, Surfactants, soil suspending agents, active ingredient sodium hydroxide. cleaning agents, various processing agents, various coloring 0441 Common formulations of oven cleaning products agents, and various quality control agents. comprise water, Surfactants, grease cutting agents, sodium hydroxide, water conditioning agents, fragrance, and various 0454. The present invention provides for novel formula coloring agents. tions of tub and shower cleaning products by incorporating bioactive glass into a combination of any of the above-listed 0442. The present invention provides for novel formula ingredients. tions of oven cleaning products by incorporating bioactive glass into a combination of any of the above-listed ingredi 0455 The antimicrobial and pH effects of bioactive glass entS. are particularly useful in tub and shower cleaning products to reduce bacteria and odor. 0443) The antimicrobial effects of bioactive glass are particularly useful in oven cleaning products to reduce Carpet Cleaning Products bacteria and odor. 0456. The present invention includes novel formulations which incorporate bioactive glass into various brands of Toilet Cleaning Products carpet cleaning products such as the products marketed 0444 The present invention includes novel formulations under the brand names Arm & Hammer, Carpet Fresh, which incorporate bioactive glass into various brands of Folex, Formula 409, Glade, Simply Spot-Less, Spot Shot, toilet cleaning products such as the products marketed under Resolve, Shout, Woolite, and products produced by high-end the brand names Blu Boy, Bowl Fresh, Clorox, Dale, Dow, and generic manufacturers. US 2007/0275021 A1 Nov. 29, 2007

0457 Generally, carpet cleaning products comprise the 0468. The abrasive and pH effects of bioactive glass are active ingredient sodium bicarbanate and fragrance. particularly useful in jewelry and metal cleaning products to 0458. The present invention provides for novel formula reduce bacteria and to remove stains. tions of carpet cleaning products by incorporating bioactive Food Preservatives, Nutritional Supplements and Functional glass into a combination of any of the above-listed ingredi Food Formulations entS. Food Preservatives 0459. The antimicrobial and pH effects of bioactive glass are particularly useful in carpet cleaning products to reduce 0469 Numerous foods are potentially infected with bac bacteria and odor. teria, Such as E. coli. Ground beef and chicken are particu larly Susceptible to bacterial infection. Aqueous solutions All Purpose Cleaning Products including an aqueous extract from bioactive glass have 0460 The present invention includes novel formulations anti-bacterial properties. The anti-bacterial effect is due, in which incorporate bioactive glass into various brands of all part, to the basic nature of the Solution (pH greater than purpose cleaning products Such as the products marketed about 7, preferably greater than about 9, more preferably under the brand names Amazing White, Biz, Borateem, greater than about 10.5). However, sodium hydroxide solu Cloralen, Clorox, Ajax, Armstrong, Barkeepers Friend, tions of relatively high pH are not as effective at killing Behold, Bon Ami, Brasso, Brite, Cameo, Cinch, Clear bacteria. Accordingly, the Solutions have additional antibac Calcium Lime Rust Remover, Clorox, Comet, Dow, Easy terial elements present than merely a relatively high pH. Off, Endust, Fantastik, Formula 409, Glass Magic, Glass 0470 The bioactive glass compositions may be sprayed Plus, International Brass & Metal Polish, Johnson, Lysol, on contaminated Surfaces, or incorporated into food prod Mop & Glo, Mr. Clean, Murphy’s, Old English, Pine O Pine, ucts such as ground beef. Since bioactive glass has been Pine Sol, Pledge, Proctor & Gamble, Orange Clean, Orange approved for various uses by the FDA, the extract of Glo, Scotts, Simple Green, Soft Scrub, Sparkle, Spic & bioactive glass should be harmless to humans. In addition, Span, Tilex, Twinkle, Xtra, Weinmans, Windex, Wright, bioactive glass has no effect on taste or texture. Wrights, and products produced by high-end and generic manufacturers. 0471. It should be noted that in addition to bioactive glass, antibiotics may also be added to food preservatives, 0461) Generally, all purpose cleaning products comprise nutritional Supplements and functional food formulations. sodium hypochlorite and/or calcium hypochlorite, a deter The addition of antibiotics to food preservatives, nutritional gent, ammonia and alcohol. Supplements and functional food formulations which 0462 Common formulations of all purpose cleaning include bioactive glass is particularly effective in formula products comprise Sodium dichloro-S-triazinetrione dihy tions which are orally ingested. drate, cleaning agents (calcium carbonate, sodium carbon Functional Foods/Nutritional Supplements ate, anionic Surfactants), perfume, various quality control agents and Various coloring agents. 0472. It has been shown in several animal models that soluble silica is essential for proper absorption/metaboliza 0463 All purpose cleaning products also may include tion of calcium. Thus, without adequate levels of soluble one or more of the following: dipropylene glycol butyl ether, silica, the effects of supplemented calcium may be defeated. citric acid, bleach, N-alkyl dimethyl benzyl ammonium Accordingly, the addition of bioactive glass to calcium chlorides, N-alkyl dimethyl ethylbenzyl ammonium chlo Supplemented foods may improve calcium absorption. ride, ammonia-D, octyl decyl dimethyl ammonium chloride, dioctyl dimethyl ammonium chloride, isopropanol and Sur 0473. In addition, antacids are increasingly being sold as factants. calcium Supplements. Accordingly the addition of bioactive 0464) The present invention provides for novel formula glass to antacid formulation may increase calcium absorp tions of all purpose cleaning products by incorporating tion, and due to its effects on pH also reduces acid. bioactive glass into a combination of any of the above-listed 0474 Likewise, other calcium supplements and calcium ingredients. added to foods such as orange juice, cereals, and nutritional shakes can benefit from the increased calcium absorption 0465. The antimicrobial and pH effects of bioactive glass provided by bioactive glass. In addition, the anti-inflamma are particularly useful in general purpose cleaning products tory properties of bioactive glass make it suitable as a to reduce bacteria and odor. Additionally, the abrasive treatment for internal inflammations such as stomach and quality of bioactive glass aids in the removal of dirt and intestinal inflammations. stains. Jewelry and Metal Cleaning Products Methods of Making 0475 For enteral administration, the bioactive glass par 0466. The present invention includes novel formulations ticulates can be incorporated into an inert carrier in discrete which incorporate bioactive glass into various brands of units such as capsules, cachets, tablets or lozenges, each jewelry and metal cleaning products such as the products containing a predetermined amount of the particles; as a marketed under the brand names Brasso, International Brass powder or granules; or a Suspension or solution in an & Metal Polish, Twinkle, and Wrights. aqueous liquid or non-aqueous liquid, e.g., a syrup, an elixir, 0467. The present invention provides for novel formula an emulsion or a draught. Suitable carriers may be starches tions of jewelry and metal cleaning products by incorporat or Sugars and include lubricants, flavorings, binders, and ing bioactive glass into any of the above-listed ingredients. other materials of the same nature. US 2007/0275021 A1 Nov. 29, 2007 42

0476 A tablet may be made by compression or molding, Amitone, Basic Nutrition, Bayer, Biotene, Black Radiance, optionally with one or more accessory ingredients. Com Brite-Life, Calcet, Cal-Max, Caltrate, Centrum Kids, Cit pressed tablets may be prepared by compressing in a Suitable racel, Dical-D, Di-Gel, drugstore.com, Enamelon, Ensure, machine the active compound in a free-flowing form, e.g., a Equalactin, Estroven, FiberCon, Flintstones, Florical, Fos powder or granules, optionally mixed with accessory ingre Free, Futurebiotics, Gas-X, GNC, Good Sense, Healthy dients, e.g., binders, lubricants, inert diluents, Surface active Woman, Konsyl, Maalox, Mylanta, Natrol, Naturalife, Natu or dispersing agents. Molded tablets may be made by ral Wealth, Naturally Scientific, Nature Made, Nature's molding in a Suitable machine, a mixture of the powdered Bounty, Nature's Reward, Nature's Way, Neo-Calglucon, active compound with any Suitable carrier. Nephro-Calci, Nutrition Now, One-A-Day, Olry. Os-cal, 0477. A syrup suspension may be made by adding the PharmAssure, PhenSafe, Phillips, Posture, Prelief, Provate, active compound to a concentrated, aqueous solution of a R&C, R&D, Rainbow Light, Revlon, Roberts, Rolaids, Sugar, e.g., Sucrose, to which may also be added any Schiff, Similac, Solgar, Stuart Prenatal, Sundown, Surfak, accessory ingredients. Such accessory ingredients may Thompson, Titralac, Tums, Twinlab, Viactiv, VitaFresh, and include flavoring, an agent to retard crystallization of the products produced by high-end and generic manufacturers. Sugar or an agent to increase the solubility of any other 0485 Common formulations of calcium supplement and ingredient, e.g., as a polyhydric alcohol, for example, glyc calcium Supplemented products comprise calcium carbon erol or sorbitol. ate, dicytl Sodium sulfo Succinate, hydrogenated cereal Sol ids, magnesium Stearate, polyethylene glycol, Sorbitol, Categories of Functional Foods/Nutritional Supplements Sugar, various artificial and natural flavorings and various 0478. One embodiment of the present invention will coloring agents. produce novel formulations which incorporate bioactive glass into various brands of a variety of functional food and 0486 Calcium supplement and calcium supplemented nutritional Supplements including: antacid products, calcium products also may include one or more of the following: Supplement products, and silica Supplement products. adipic acid, silicon dioxide, Sodium polyphosphate, starch, talc, aspartame, mannitol, maltodextrin, cellulose, mineral Antacid Products oil, crospovidone, hydroxypropyl methylcellulose, Veg 0479. The present invention includes novel formulations etable glycerides, acacia gum, titanium oxide, polysorbate which incorporate bioactive glass into various brands of 80, sodium lauryl sulfate and stearic acid. antacid products such as the products marketed under the 0487. The present invention provides for novel formula brand names Alka-Mints, Alka-Seltzer, Amitone, Axid, tions of calcium Supplement and calcium Supplemented Brite-Life, Bromo Seltzer, Di-Gel, Gas-X, Gaviscon, Gelu products by incorporating bioactive glass into a combination sil, Good Sense, Imodium, Kaopectate, Lactaid, Maalox, of any of the above-listed ingredients. Mag-OX, Mylanta, Pepcid AC, Pepto-Bismol, Phazyme, Phillips, Prelief, Riopan, Rolaids, Sal De Picot, Tagamet, Silica Supplemented Products Tempo, Titralac, Tums, Zantac, an products produced by 0488 The present invention includes novel formulations high-end and generic manufacturers. which incorporate bioactive glass into various brands of 0480 Common formulations of antacid products com silica Supplement and silica Supplemented products includ prise aspirin, Sodium bicarbonate, citric acid, sodium citrate, ing the following: dietary Supplements in pill and chewable Sodium acetylsalicylate, aspartame, flavor and phenylala form, toothpaste, shampoo, body wash, and various food nine. seasonings and spreads, such as the products marketed under the brand names Body Essential, Crest, Futurebiotics, GNC, 0481 Antacid products also may include one or more of Natrol, Nature's Herbs, Nature's Way, Peter Thomas Roth, the following: calcium carbonate, magnesium Stearate, min and high-end and generic manufacturers. eral oil, Sodium hexametaphosphate, starch, Stearic acid, Sucrose, talc, aluminum hydroxide, magnesium carbonate, 0489 Common formulations of silica supplement and alginic acid, calcium Stearate, aspartame, croScarmellose silica Supplemented products comprise Stearic acid, dical Sodium, silica, various artificial and natural flavorings, and cium phosphate, cellulose, and magnesium Stearate. various coloring agents. 0490 Silica supplement and silica supplemented prod 0482. The present invention provides for novel formula ucts may also include one or more of the following: rice tions of antacid products by incorporating bioactive glass powder, silica, gelatin and water. into a combination of any of the above-listed ingredients. 0491. The present invention provides for novel formula 0483 The anti-inflammatory and antimicrobial effects of tions of silica Supplement and silica Supplemented products bioactive glass are particularly useful in antacid products to by incorporating bioactive glass into a combination of any of reduce inflammation and bacteria. the above-listed ingredients. Calcium Supplement Products 0492 Alternatively, bioactive glass itself may be consid ered the silica Supplement or may replace the silica found in 0484 The present invention includes novel formulations existing formulations of silica Supplements. which incorporate bioactive glass into various brands of calcium Supplement and calcium Supplemented products 0493 Applicants have found that bioactive glasses pro including: dietary Supplements in pill and chewable form, vide Superior and unexpected results in comparison to antacids, pain relievers, toothpaste, cereals, Snack foods, standard dietary silica Supplements. Applicants have found beverages, and various food seasonings and spreads Such as that bioactive glasses release soluble silica into physiologi the products marketed under the brand names Alka-Mints, cal environments in beneficial ways that have notheretofore US 2007/0275021 A1 Nov. 29, 2007

been appreciated. Bioactive glasses also provide for an tile, to name a few, to make these products highly resistant unusually large physical Surface area that presents silanol to microbial contamination and to increase the pH. groups which have activity that in many ways is similar to soluble silica. Note that this is particularly true for sol-gel 1-134. (canceled) derived glasses. 135. A non-irritating, stable personal care composition comprising bioactive glass and a personal care product. 0494. Applicants have found that both the released 136. The composition of claim 135 further comprising at soluble silica and the available silanol groups provide for an least one Substance that is skin-irritating when not in the efficient mechanism for sequestering and removing metal composition. ions from the body. The glass particles, which may be 137. The composition of claim 135, wherein the bioactive micron-sized, sequester or bind metal ions and are flushed glass is an aqueous extract. through organs of the body (e.g. the kidneys and intestines) 138. The composition of claim 135, wherein the personal and excreted from the body. In this way, bioactive glasses care product is selected from the group consisting of diaper can be used to reduce or minimize the toxic effects of many products, adult incontinence products, feminine hygiene metal ions. products, shampoo products, hair care products, deodorant 0495 Bioactive glasses are particularly helpful in reduc products, foot care products, baby care products, Sunscreen ing or minimizing the toxic effects of aluminum. In addition products, body cleanser products, skin care products, and to the sequestering or binding discussed above, bioactive nutritional Supplement products. glasses release additional calcium and phosphate, which 139. The personal care composition of claim 135, wherein aluminum tends to bind. The aluminum So bound is thus the pH of the composition is between about 8 and about 12. made less available for toxic effects or damaging physi 140. The personal care composition of claim 135, wherein ological processes. the composition reduces odor. 141. A method of reducing odor comprising applying the 0496 Accordingly, dietary supplements incorporating personal care composition of claim 140 to a source of odor. bioactive glass may be beneficial for treating or preventing 142. The personal care composition of claim 135 wherein many harmful disease processes and conditions associated the composition exhibits UV-filtering properties. with, for example, aluminum including, but not limited to, 143. The personal care composition of claim 142, wherein osteoporosis, osteodystrophy, and other conditions in which the composition comprises Sunscreen. stimulation of osteoblastic activity is desired. 144. A method of blocking UV light from exposed skin 0497. In addition, these dietary supplements by binding comprising applying the personal care composition of claim aluminum, may be beneficial in preventing, slowing, or 142 to the exposed skin. reversing the effects of Alzheimer's disease, various forms 145. The personal care composition of claim 135 wherein of encephalopathy, and various forms of myocardial dys the composition exhibits moisture-absorbing properties. function. 146. A method of absorbing moisture comprising apply ing the personal care composition of claim 145 to a source 0498. In addition to aluminum, bioactive glass can be of moisture. used to bind other metal ions, including, for example, lead, 147. The personal care composition of claim 135 wherein cadmium, Zinc, and iron. Accordingly, harmful or toxic the personal care product is a hair care product and wherein effects of these and other metal ions may be prevented, the composition provides a mineral coating to the hair. slowed, or reversed. 148. A nutritional Supplement composition comprising Miscellaneous Products bioactive glass and a nutritional Supplement. 0499. In addition to the products listed above, bioactive 149. The composition of claim 148, wherein the bioactive glass may be added to or included in the following house glass is an aqueous extract. hold products: dust filters, wall paint/wallpaper, toilet seat 150. The composition of claim 148, wherein the nutri covers, mold remover, ceramic/bathroom tile laminates, tional Supplement is selected from the group consisting of water filters, mattress fillers, cleaning agents for Solariums antacids, calcium Supplements, and silica Supplements. and Sun beds, toilet brushes, pet litter (Such as the products 151. The composition of claim 148, further comprising marketed under the brand names Litter Clean, Tidy Cat, Arm iodine. & Hammer, Classy Cat, Everfresh, Fresh Step, Jonny, Sani 152. A cleaning agent composition comprising bioactive Scoop and Scoop Away) and cutting boards to make these glass and a cleaning agent. products highly resistant to microbial contamination and to 153. The method of claim 152, wherein the bioactive glass increase the pH. is an aqueous extract. 154. The composition of claim 152, wherein the cleaning 0500 The present invention also provides novel products agent is selected from the group consisting of laundry useful in the animal care and veterinary fields. Bioactive detergents, stain removers, fabric Softening products, dish glass may also be added to or included, for example, in the washing products, air fresheners, deodorizing products, following animal/veterinary products to make these prod bathroom tissue, facial tissue, paper towel products, napkin ucts highly resistant to microbial contamination and to products, cotton Swabs, handiwipes, scouring products, increase the pH: sand for bird cages, kitty litter, flea powder, sponge products, oven cleaning products, toilet cleaning and dry shampoos for animals. products, tub and shower cleaning products, carpet cleaning 0501 Bioactive glass may also be added to or included in products, all purpose cleaning products, jewelry products, the following products: fungicide?pesticide for agriculture, and metal cleaning products. marine antifoulant, coating for glass and cleaners for indus trial food and beverage containers, concrete, ceramics, and k k k k k