ANNUAL REPORT 2014 Contents
Introduction ...... 3 Mission Who we are, what we do Garvan’s aspirations
Reports ...... 4 Chairman’s report ...... 4 Executive Director’s report ...... 5 Garvan Research Foundation Chairman’s report ...... 6
The Organisation ...... 7
Garvan at a Glance ...... 8 The year at a glance ...... 8 Philanthropic income ...... 8 Staff and student profile ...... 9 Scientific publications ...... 9 Public and community engagement ...... 9
Research Divisions and Centre ...... 10 Bone Biology...... 10 Cancer ...... 14 Diabetes and Metabolism ...... 18 Immunology ...... 22 Neuroscience ...... 26 Kinghorn Centre for Clinical Genomics ...... 30
Governance ...... 35 Garvan Institute of Medical Research ...... 35 Garvan Research Foundation ...... 39
Leaders in Science Seminars ...... 42
Garvan Community ...... 44 Life Governors ...... 44 Partners for the Future ...... 44 Volunteers...... 44 2014 supporters ...... 45 Young Garvan supporters ...... 47 Love Your Sister ...... 47 Bequests ...... 47
Peer Reviewed Funding ...... 48
Financial Highlights ...... 50 Income statement ...... 50 Balance sheet ...... 51
2 Mission
The mission of the Garvan Institute of Medical Research is to make significant contributions to medical research that will change the directions of science and medicine and have major impacts on human health.
Who we are, what we do
Garvan pioneers studies into For more than 50 years, significant • Osteoporosis some of the most widespread breakthroughs have been achieved • Immunological diseases such diseases affecting our by Garvan scientists in the as asthma, rheumatoid arthritis community. Research at Garvan understanding and treatment of and multiple sclerosis. is focused upon understanding diseases such as: the role of molecular and cellular Garvan’s ultimate goal is • Cancer processes in health and disease prevention, treatment or cure of as the basis for developing • Diabetes and obesity these major diseases. future preventions, treatments • Neurological diseases such and cures. Garvan is leading the as Alzheimer’s disease, nation in using genomic analysis Parkinson’s disease, hearing to accelerate discovery and loss, mental illnesses and enable precision medicine. eating disorders
Garvan’s aspirations
• To become the most advanced osteoporosis, diabetes, obesity, • To embrace and uphold institute in the region in the and immunological, skeletal a culture of collegiality, adoption, application and and neurological diseases, and collaboration, inclusivity, integration of next generation influence health policy. consideration, safety, genomic and computational transparency and high • To attract, develop and approaches and technologies ethical standards. support exceptionally talented in investigative and researchers with leading • To engage stakeholders and translational research. edge programs addressing the community with our • To advance knowledge in our key conceptual and practical achievements and research key areas of focus that will questions in human biology, vision so that we attract the lead to better understanding, and the translation of new significant government and donor reduced incidence and knowledge and technologies support needed to empower our improved treatments for cancer, into clinical applications. transformative agenda.
GARVAN 3 Chairman’s Report Garvan Institute of Medical Research
Before I accepted the invitation to become the Chair of the Board of the Garvan Institute of Medical Research, disease avoidance and mitigation, leading to I naturally undertook due diligence far better health for individuals and society, about the Institute and its people. with many benefits to our economy and I was impressed. quality of life. However, my due diligence was inadequate. Recognising the importance for NSW and I had underestimated the quality of Garvan’s Australia, this potential has attracted $24m in staff. What I also discovered is that Garvan NSW Government support for leading-edge leads the nation and is among the leaders of programs that can take advantage of KCCG’s the world in the development and application infrastructure. These include sequencing of genomic technologies in medical research populations that have survived to old age and clinical translation. The pace of change without any of the common problems, is exhilarating. Just over a decade ago it including cognitive decline, and identifying cost more than a billion dollars to sequence wellness factors, as well as identifying the human genome. This year the US inherited cancer risk. A number of projects company that leads the field, Illumina, chose are also underway with clinicians around the Garvan to be one of the first centres in the state to investigate the genetic contributions world to acquire the technology capable of to schizophrenia, melanoma, mitochondrial sequencing human genomes for a base cost disease and congenital heart disease, among of US$1,000. many others to come. This choice reflected respect for the I encourage all readers to go to Garvan’s Australian healthcare system and medical website to learn more about KCCG and to research capability, and for the leadership at explore the range of outstanding research Garvan which understands that genomics and researchers that we are fortunate to is not only essential to understanding have at Garvan. human disease, but also that it is ready for the clinic. To this end, with the generous I would also like to thank a number of support of The Kinghorn Foundation, Garvan Board members, who retired or resigned was able to purchase the Illumina HiSeq in 2014, namely Jonathan Anderson, John XTen sequencing system which is capable Horvath AO, Warren Scott, Greg Paramor of sequencing more than 300 genomes AO and Lisa McIntyre, for their outstanding every week. Garvan also established the contributions to Garvan over many years. Kinghorn Centre for Clinical Genomics I would also like to welcome our new (KCCG), with the analytical pipelines required Board Members Helen Nugent AO, Patricia to assemble and interpret the avalanche of O’Rourke and Anthony Schembri.
new information. Dr John Schubert AO KCCG now has more than 30 staff and is
developing wonderful collaborations with clinicians and scientists around the country This choice reflected respect for the and beyond to explore the genetic basis of Australian healthcare system and “ illness. This includes inherited and acquired medical research capability, and for the genetic disabilities, cancer diagnosis and leadership at Garvan which understands “that genomics is not only essential to adverse drug reactions among others. Personal genome sequencing will become understanding human disease, but also the norm in the not-too-distant future and that it is ready for the clinic. incorporated into healthcare, focused on
4 We continue to strengthen our relationships with UNSW Australia and with our partners Executive on the Darlinghurst precinct, including St Vincent’s Hospital and the Victor Chang Cardiac Research Institute, working strategically to build critical mass and Director’s capability in medical research and translation into clinical practice, as well as training opportunities for students. In January 2014 we also launched a revamped website (www.garvan.org.au), Report which has enhanced content. The website offers virtual tours of our facilities and links to a number of social media platforms that we are increasingly using to communicate 2014 was a year of growth and renewal. our activities and achievements. I came to Garvan three years ago with the intention of transforming Our researchers had another successful the Institute into the first of the next- year in obtaining peer-reviewed grant and generation medical research institutes fellowship support, with Garvan once again that places understanding human among the best performing institutions genomic information at the centre of its in the nation. However many challenges research and translational endeavours. remain because of declining success rates across the sector due to increased We achieved a great deal towards this goal competition for static government funding. in 2014. We were given the opportunity to We are optimistic that the forecast Medical be one of the first institutions to acquire the Research Future Fund will redress this technology to sequence human genomes situation in the future, but it is clear that at at large scale. Garvan also successfully the moment we must diversify our sources introduced new gene editing technology to of research funding. rapidly replicate human mutations in mice to model human disease in our mouse In this and other respects, Garvan is facilities at Moss Vale. This increases fortunate to have outstanding supporters our capability in functional genomics, an from the business, arts and broader essential part of the research pipeline. communities, some of whom are members of the Garvan Institute and Garvan Research Our genomics capability and focus is Foundation Boards. attracting some of the world’s best researchers to join Garvan, including On behalf of my colleagues, I thank you for Professor David Thomas, Director of your contributions over many years. The Kinghorn Cancer Centre and Head On your behalf I thank my colleagues, both of Garvan’s Cancer Division, as well as in research and in support roles, for their Garvan’s new Deputy-Director, Professor outstanding work, often long into the night. Chris Goodnow. Professor John Mattick AO FAA At the end of 2014 we decided to give genomic science and our world-leading research in epigenetics greater exposure by creating a new Division of Genomics and Epigenetics, led by Professor Susan Clark. While we welcomed several excellent new researchers in 2014, we bade sad farewell to others. After many years at Garvan, Professor David James relocated his
research team to the Charles Perkins Centre at the University of Sydney. Professor Greg
Cooney provided expert leadership to the Division of Diabetes and Metabolism as Acting Head while we undertook a search for a new Division Head. We were very “ pleased to attract Professor Mark Febbraio from the Baker IDI Heart and Diabetes Institute in Melbourne to the position and he Our genomics capability and focus is will join Garvan in early 2015. attracting some of the world’s best “researchers to join Garvan… GARVAN 5 We continued to receive generous support from a wide cross section of the Australian community, Chairman’s such as Mrs Janice Gibson and the Ernest Heine Family Foundation, Mrs Jane Hemstritch, the Roth Charitable Foundation, The Walker Family Foundation, the NSW Government, The Ross Report Trust and the MLC Community Foundation. Corporate giving also grew in 2014 with Garvan, in partnership with Ridley Corporation, rolling Garvan Research Foundation out our Healthy Families, Healthy Communities program across rural and regional Australia. The work of our American entity – Friends of the Garvan US – included a luncheon in New York hosted by Castle Harlan Inc. with Professor John Mattick as keynote speaker. Our thanks to the members of the American Board, Mr Len Harlan (President), Mr Bill Ferris, Mr David Anstice and Mr Phil Handy, for their leadership. Community fundraising and our direct marketing campaigns provided the opportunity to raise awareness of Garvan’s work and saw another increase in regular donations and from direct marketing campaigns. There was also an increase in gifts or donations in lieu of flowers at funerals. We also received several significant bequests which were used to develop our core research areas and to strengthen our strategic reserves. I am particularly grateful to these Garvan had a very successful 2014 thanks supporters for their long-term vision for to the generosity of many individuals, Garvan’s research programs. foundations and corporations, with more than $21,000,000 in support received. The Young Garvan Committee continued it’s outstanding work of raising the profile – and funds A highlight of the year was the Love Your Sister – for Garvan via its public forums and annual All campaign featuring actor Samuel Johnson Ribbons Ball. Congratulations to all members of riding a unicycle around Australia as part of a the Committee for their efforts. campaign inspired by his sister Connie, who has been diagnosed with terminal breast The Garvan Gala was another highlight of the cancer. They both worked tirelessly throughout year. Ms Virginia Trioli was again our Master the year and raised an incredible $2,000,000 of Ceremonies and thank you to our menu to support Garvan’s breast cancer research designers, Mr Neil Perry and Mr Guillaume programs. In recognition of their effort we have Brahimi, and the scholarship winners from established the Connie Johnson Fellowship in the John Brown Foundation who provided Breast Cancer Research. entertainment on the night. The year started with Garvan’s purchase of the I would like to acknowledge the work of our HiSeq X Ten System, capable of sequencing Chief Executive Officer, Andrew Giles, and his 18,000 human genomes per year at the base executive team: Kylie Ironside, Dimity Raftos, price of $US1000 per genome. The system was Mara-Jean Tilley and Leonie Walton, whose funded through the generosity of The Kinghorn outstanding work took the Foundation to a new Foundation. This incredible philanthropic level in 2014. gesture has underpinned much of Garvan’s I would like to also acknowledge the ongoing work in 2014, lending the power of genomics to support of my fellow Board members for their all our research areas. commitment and diligence throughout the year. In 2014 we received wonderful support A particular thanks to the three retiring members from The Bill and Patricia Ritchie Foundation of the Board, Sister Clare Nolan, Ms Lynnette who endowed a Chair in memory of Bill Gearing and Mr Wal King for their years of and Patricia Ritchie. This has enabled the dedication and service to Garvan. appointment of Professor Chris Goodnow as Finally, a sincere thank you to the many the Institute’s inaugural Deputy Director. thousands of individual donors who have supported Garvan in 2014. Geoff Dixon
6 The Organisation
Chair Executive Director Chair Dr John Schubert Prof John Mattick Mr Geoff Dixon Chief Executive Officer Chief Operating Officer Chief Scientific Officer Mr Andrew Giles Mr Philip Knox Dr Marie Dziadek Australian BioResources Communications and Education Dr Jenny Kingham Mr Nick Hall Partnerships and Legal Affairs Ms Alison Heather Board Committees Ms Christina Hardy Ms Bronwyn Terrill Finance, Risk and Audit Finance and Accounting Grants Administration Investment Mrs Cherry Dutton Ms Sonja Bates Partnerships Advisory Dr Gillian Hulst Remuneration Human Resources Mr Simon Hamilton Research Governance Institute Committees Dr Rayson Tan Information Technology Executive Management Ms Therese Yim Mr George Constantinescu Appointments Mr Gerard Hammond Student Programs Facilities and Equipment Dr Alessandra Bray Higher Degrees Operations Post Doc Development Mr Michael Emerson Promotion WHS and Compliance Scientific Advisory Council Ms Lisa Moncur WHS Consultation Workplace Equity Bone Biology Division Dr P Baldock Prof T Nguyen Australian BioResources Prof Peter Croucher A/Prof J Center Prof M Rogers Board Prof J Eisman Advisory The Kinghorn Cancer Centre Cancer Division Prof A Biankin Dr T Mercer (TKCC) Committees Prof Susan Clark Prof S Clark Prof C Ormandy TKCC Building Management Prof David Thomas A/Prof M Dinger Dr A Swarbrick TKCC Communications Prof V Hayes Prof N Watkins TKCC Executive Management A/Prof M Kohonen- Corish St Vincent’s Research Precinct (SVRP) Committees The Kinghorn Cancer Centre Prof David Thomas Executive Council Research Council Animal Ethics Diabetes and Prof T Biden Prof T Kraegen Human Research Ethics Metabolism Division Prof L Campbell A/Prof R Laybutt Institutional Biosafety Prof Gregory Cooney Prof D Chisholm Prof K Samaras A/Prof J Greenfield Dr C Schmitz-Peiffer SVRP Management Dr W Hughes SVRP Operations SVRP WHS Immunology Division Prof A Basten A/Prof C King Prof Robert Brink A/Prof D Christ Prof J Sprent A/Prof S Grey A/Prof S Tangye Prof J Gunton
Neuroscience Division A/Prof A Cooper Prof D Ryugo Prof Herbert Herzog Prof J Mattick Prof J Shine Dr G Neely Dr B Vissel
Kinghorn Centre for Clinical Genomics A/Prof Marcel Dinger
GARVAN 7 Garvan at a Glance
Total income 20% $75,244,000 NHMRC grants $15,393,000 14% Other income 20% $10,220,000 Other peer-reviewed grants 29% $15,391,000 Donations and bequests 5% $21,622,000 NHMRC and UNSW infrastructure $3,512,000 12% NSW government support $9,105,000
Total expenditure 14% $79,961,000 Depreciation and amortisation $11,282,000 52% Research laboratories 3% $41,613,000 Fundraising $2,149,000 7% Administration $6,332,000 13% 2% Business development Research facilities $1,208,000 $10,491,000 9% Building operations $6,885,000
Philanthropic income 2011 2013 2012 2014 Total income with bequests 2010 Total income without bequests $15,554,000 $12,573,000 $24,463,000 $18,107,000 $21,050,000 $20,338,000 $23,000,000 $15,377,000 $21,622,000 $18,067,000
8 Staff and student profile 635
Research staff 252 people
112 Men 140 Women
Visiting scientists 111 people
61 Men 50 Women
Postgraduate students 102 people
43 Men 59 Women
Undergraduate students 5 Men 19 Women 24 people
Administrative and support staff 132 people 59 Men 73 Women
Fundraising and 2 Men 14 Women marketing staff 16 people
Scientific publications Public and community 276 engagement Total publications including: Journal articles, reports, 2,383 reviews and People were engaged through: book chapters
263 21 Free public tours and presentations 191 people In journals with an Impact Factor (IF, a measure of importance; not all 11 External presentations to journals have an IF) 220 people community groups 2014 Target: average IF of 8.0 for top 80% of these Corporate tours 1000 900 3 Seminars Achieved: average IF of people and presentations people 8.13 for top 80%
GARVAN 9 GARVAN.ORG.AU BONE BIOLOGY Professor Peter Croucher Division Head
WHAT WE DO RESEARCH HIGHLIGHTS This unique research project is an outstanding example of an international Many Australians are likely to develop New anti-cancer properties revealed collaboration, involving researchers some form of musculoskeletal for bone drug from Melbourne, New York and San disease in their lifetimes, so improving A study led by Professor Mike Rogers Diego in the USA, Lisbon in Portugal diagnosis, treatment and quality of life has shown for the first time why calcium- and the Universities of Oxford and for affected people is a critical priority binding drugs commonly used to treat Sheffield in the UK. Within Garvan, the for our Division. people with osteoporosis or cancers Division is collaborating with the Cancer We focus on two main areas of that have spread to bone, may also Division, TKCC, KCCG and utilising the research: osteoporosis and bone benefit patients with tumours outside the Small Animal Imaging Facility. These oncology, particularly multiple skeleton, including breast cancer. groups represent highly experienced myeloma and tumours in bone that investigators in prostate cancer, bone In collaboration with colleagues Dr Tri have metastasised from breast and biology, breast cancer, transcriptomics Phan, from the Immunology Division, prostate cancer. and genomics. Together they are and Dr Simon Junankar, the study used investigating the spread of prostate Collaboration is vital to maximising sophisticated imaging technologies to cancer cells to the skeleton, one of the the impact of our research and reveal that bisphosphonates attach to most devastating consequences of we collaborate widely with other tiny calcifications in tumours that are then advanced prostate cancer. Divisions within Garvan, as well as devoured by macrophages, immune cells leading programs in Australia and that play many roles in the body, one of Once a cancer spreads to bone and around the world. which is to ‘clean-up’ dead or dying cells starts growing, it becomes notoriously and cellular debris. difficult to treat. The team hopes to Over the past three years, our answer the vital question of whether Division has doubled in size, thanks to The findings provide a rationale for using bone-active drugs can retain cancer generous funding from long standing bisphosphonates for women with early- cells in a dormant state for a long supporters – Mrs Janice Gibson and stage breast cancer, rather than just to period of time, to stop them being the Ernest Heine Family Foundation. treat bone disease. activated and forming tumours. Our Division now comprises six laboratories with more than 40 staff Unique collaborative project and students. awarded prestigious funding More information and staff profiles are An international interdisciplinary available at research group led by Professor
Peter Croucher received one of two garvan.org.au/research/bone-biology Movember Revolutionary Team
Awards from the Prostate Cancer Foundation of Australia in 2014. For us, collaboration is vital to “ The award provides a total of $3 maximising the impact of our million for a project investigating
Garvan Institute of Medical Research · Foundation Annual Report 2014 Bone Biology Division research. We collaborate widely advanced prostate cancer. with other Divisions within Garvan, The project, called ‘ProMis’ (Prostate “as well as leading programs in Australia and around the world. Cancer Metastasis), is investigating the mystery of why some cancer cells spread to the bone but remain inactive there for a very long time.
10 Professor John Eisman GARVAN.ORG.AU was invited as a visiting Professor to Maastricht University Medical Centre in the Netherlands as part of a collaborative research project 40STAFF AND analysing international STUDENTS osteoporosis management.
WHEN CANCER CELLS SPREAD TO BONE, THEY CAN REMAIN INACTIVE FOR A VERY LONG TIME AND ARE NOTORIOUSLY DIFFICULT TO FIND AND TREAT.
‘SCARY BONES’ CAMPAIGN HIGHLIGHTS THE SKELETON IN THE CLOSET For more than 25 years In Australia, ‘bone failure’ potentially leading to Garvan’s Dubbo Osteoporosis fracture affects 2.2 million people. However, not Epidemiology Study has provided everyone knows that treatment is available to prevent major insights into osteoporosis. bones from failing. Drugs such as bisphosphonates It remains the longest running are available that strengthen bones and reduce the study of osteoporosis in men and chance of a fracture occurring. women worldwide. Predictive tools like Garvan’s Fracture Risk Calculator are useful in identifying individuals at high risk who would benefit from this type of treatment. Professor John Eisman is spearheading the ‘Scary Bones’ campaign to raise awareness about the importance of bone health, jolt the community into action and, if they have had a fracture or are at high risk, to get treatment. Findings have provided a rationale for using bisphosphonates in the clinic for the treatment
of some cancers. Garvan Institute of Medical Research · Foundation Annual Report 2014 Bone Biology Division
GARVAN 11 GARVAN.ORG.AU INTERNATIONAL COLLABORATION INVESTIGATES OSTEOPOROSIS MORTALITY RATE While analysing the data from our Dubbo Osteoporosis Epidemiology Study, Associate Professor Jacqueline Center, Head of the Clinical Studies and Epidemiology Laboratory, and Professor John Eisman identified that the mortality rate in people with osteoporosis increases dramatically (almost twofold) following all major fractures. They are now leading an innovative, international collaborative project aiming to Garvan Fracture Risk Calculator app. Associate Professor Jacqueline Center. understand the basis for the high mortality rate. By teaming up with researchers from Canada, Norway, EDUCATING GPs AND OUR RESEARCH LABORATORIES Holland, Denmark, UK and Italy THE COMMUNITY Bone Biology and analysing their data, Associate Improving osteoporosis prevention Laboratory Head, Professor Center hopes to better and treatment in the community Professor Peter Croucher understand what factors might be influencing the post-fracture Garvan researchers developed the Bone Therapeutics mortality rate. Garvan Fracture Risk Calculator Laboratory Head, Professor Mike Rogers using data gathered from the Dubbo Clinical Studies and Epidemiology Associate Professor Center has Osteoporosis Epidemiology Study. Laboratory Head, already identified that while The Calculator is being refined to Associate Professor Jacqueline Center osteoporosis medication acts assess fracture-associated outcomes to decrease the risk of a repeat Genetic Epidemiology of Osteoporosis and to improve its clinical use as a fracture, it also, independently, Laboratory Head, Professor Tuan Nguyen predictive tool. decreases the mortality rate of Osteoporosis and people with osteoporosis. General Practitioners (GPs) play Translational Research an important part in identifying Laboratory Head, and counselling patients at risk of Professor John Eisman AO osteoporosis and treating people who SMALL ANIMAL IMAGING have suffered an osteoporotic fracture. Skeletal Metabolism Thanks to a grant from the NHMRC, Laboratory Head, Dr Paul Baldock Garvan’s Small Animal Imaging Professor John Eisman AO, Head Facility is designed for studying of Osteoporosis and Translational disease development in a whole Research, and Dr Yvonne Selecki are animal or whole tissue rather than in developing another tool for GPs – thin tissue sections. The facility has dubbed BoneTracker. state-of-the art imaging technologies that allow our scientists to: This web-based tool, based on the Garvan Fracture Risk Calculator, is • Localise tumours to skeletal designed to extract critical clinical and non-skeletal sites within information from a patient’s medical a living animal record and translate that to risk and • Monitor tumour progression also directly to the drug treatments and assess the impact of the that are available and covered by the tumour on bone over time Pharmaceutical Benefits Scheme. • Visualise at high resolution Garvan Institute of Medical Research · Foundation Annual Report 2014 Bone Biology Division Within two years, it should allow doctors to clearly and simply present subcellular events that the risk of fragility fractures and the take place deep within live Imaging of bioluminescent human prostate diseased tissue risks of NOT treating them and readily cancer cells (PC3 cell line) via IVIS Spectrum present the options for treatment to 5 weeks post injection into a mouse, showing • Monitor molecular changes in empower the patient and enhance a co-localisation with bone using the IVIS cells and tissues in response shared decision between the patient Quantum CT. to drug treatments. and their doctor.
12 L’Oreal Girls in GARVAN.ORG.AU Science Forum
Dr Marie Dziadek, Chief Scientific Officer and TV Hosted at Garvan personality Kate Peck, MC.
In August 2014, Garvan hosted the L’Oreal Australia and New Zealand Girls in Science forum for the first time in Sydney. We welcomed 240 schoolgirls in years 9 to 11 from 14 different high schools throughout Sydney. Dr Vanessa Kellermann and Dr Cara Doherty, two of the 2014 winners of the L’Oreal For Women in Science Fellowships, spoke passionately about their research and experiences as women in science and answered a great range of interesting questions on life as a scientist. Students and teachers were taken on a tour of Garvan guided by enthusiastic female PhD students and postdoctoral fellows who described the thrill of scientific discovery and motivated the schoolgirls to consider a career in science. School girls on a tour of Garvan.
Garvan Students Win 3MT Competition
The Three Minute Thesis (3MT) is a research communication competition, originally developed by The University of Queensland and held nationwide. PhD students explain their research in three minutes in language appropriate to an intelligent, but non-specialist audience, using a single slide to illustrate their research topic. The participants develop excellent communication skills and have lots of fun training for the award night. Garvan has organised a St Vincent’s Precinct 3MT competition for the last two years, with generous 3MT winners Ira Deveson, Qian Du and Rodrigo awards donated from the Garvan Research Foundation. Vazquez-Lombardi. Winners of the Precinct competition then compete in the UNSW Medicine event. Garvan PhD students won first, second and third place in the 2014 3MT competition. Ira Deveson took out first place with his presentation, “Recipes for a human being”.
gene transcript product Rodrigo Vazquez-Lombardi came second with his Garvan Institute of Medical Research · Foundation Annual Report 2014 Girls in Science Forum 3MT Competit ion presentation, “The A(nti cancer)-Team”, while third prize went to Qian Du for her presentation, “Dance of the DNA”.
The ‘Recipes for a human being’ presentation.
GARVAN 13 GARVAN.ORG.AU CANCER Professor David Thomas Professor Susan Clark Division Head (from June 2014), Acting Division Head (until June 2014) Director, The Kinghorn Cancer Centre
WHAT WE DO RESEARCH HIGHLIGHTS This solves a decades-old mystery and explains how some tumours Cancer remains a leading cause of death Early detection window when ensure their own survival by hijacking in Australia despite new treatments pancreatic cancer is in the family and amplifying cancer-causing DNA and early detection improving the Some individuals with pancreatic cancer regions, including ‘oncogenes’ that outlook for many; by 2020, there will be are likely to have inherited a genetic drive cancer development. 149,000 cancer diagnoses each year. predisposition to cancer. New research Our Division studies the mechanisms Blocking these massively amplified by Professor Andrew Biankin and PhD underpinning cancer and works to bring oncogenes results in cancer cell death, student Dr Jeremy Humphris shows the new discoveries into the clinical setting highlighting their potential as targets for potential benefits of identifying these and translate research discoveries into treatment of tumours like liposarcoma. individuals so that early cancer detection patient benefits. strategies can be put in place. Moving towards the creation of Our research focuses predominantly on They studied a large cohort of blood stem cells in the laboratory breast, prostate, ovarian and pancreatic pancreatic cancer patients, and found cancers, being some of the most Dr Georgina Hollway and colleagues that roughly 9 per cent had a first- common or the most lethal of cancers. from Monash University have used degree relative (parent or sibling) We have, more recently, broadened our zebrafish to uncover a mechanism with pancreatic cancer and that these focus to include sarcomas and other essential for forming haematopoietic patients were far more likely to have at neglected cancers. stem cells. These are a very special least one other form of cancer. group of cells in the early embryo that Many of our research laboratories In affected parent-child pairs, the ultimately generate all the blood and are located in The Kinghorn Cancer majority of children had a cancer immune cells in our bodies. Centre (TKCC), a joint venture diagnosis around 12 years earlier between the Garvan Institute and St The finding moves us closer to one than non-familial cases. The research Vincent’s Hospital that brings together of the holy grails of modern medicine suggests that it should now be possible scientific and medical expertise – being able to make haematopoietic to identify novel susceptibility genes aiming to improve outcomes for stem cells in the laboratory for that predispose to pancreatic and other cancer patients. By working side by transplantation. cancers, and design screening programs side, researchers and clinicians have for genetically susceptible people to created an environment in which Potential new drug therapy diagnose cancer at an early stage. clinical challenges can drive laboratory identified for pancreatic cancer research, and research findings can be Solving the mystery of Researchers are trying to identify applied to clinical care. neochromosomes genetic mutations in cancer that drive As a Division, we have more than 210 cancer growth. The aim is to see if
Massive DNA molecules, called staff and students. Further information there are drugs available that target neochromosomes, are present in and staff profiles are available at pathways disrupted by the mutation.
3 per cent of cancers and Professor Research led by Dr Ilse Rooman found garvan.org.au/research/cancer David Thomas led a team of driver mutations in the SOX9 gene in
Garvan Institute of Medical Research · Foundation Annual Report 2014 Cancer Division Australian researchers to discover “ pancreatic cancer. By working side by side, researchers how they are formed. They found that and clinicians have created an neochromosomes develop by the The researchers reported that SOX9 is environment in which clinical ‘stitching together’ of distinct parts of critical in the development of pancreatic challenges can drive laboratory different chromosomes. cancer and that SOX9 acted through “research, and research findings can the Epithelial Growth Factor Receptor be applied to clinical care. pathway, for which drugs are currently in clinical use in other cancer types.
14 GARVAN.ORG.AU
Prostate and breast cancer under AWARD AND RECOGNITION Laura Baker, a PhD student in the the molecular microscope HIGHLIGHTS Division’s Tumour Progression Laboratory, won the Castle Harlan A study led by Professor Susan Clark New leader takes the helm Award in 2014. Castle Harlan, a used simultaneous genome-wide Professor David Thomas, coming from distinguished private equity firm based mapping of DNA methylation and the Peter MacCallum Cancer Centre in in the US, supports Garvan’s medical nucleosome occupancy to examine Melbourne, was appointed as head of research with an annual award of epigenetic alterations in prostate and the Cancer Division and the Director of US$10,000 presented to an outstanding breast cancer cells. Nucleosomes The Kinghorn Cancer Centre in June PhD student. provide a scaffold in the nucleus to 2014. He took over from Professor organise DNA into its functional domains Congratulations to Saul Bert, the Susan Clark who was Acting Division and their configuration impacts on the 2014 Garvan Thesis Prize winner. Head from the start of January 2013. expression of genes. Saul completed his PhD in Professor Susan Clark’s Epigenetics Research This research found that nucleosomes Cancer Institute NSW Laboratory, researching “Mechanisms are disorganised in cancer cells, Fellowships awarded of long range epigenetic deregulation in contributing to an altered genome-wide Dr Marina Pajic, leader of the prostate cancer”. architecture and deregulation of gene Personalised Cancer Therapeutics expression associated with malignancy. Group and Dr Mark Cowley, Team Leader in Translational Genomics, were awarded Cancer Institute NSW INAUGURAL PETRE FOUNDATION fellowships. These provide salary and CHAIRS APPOINTED project support to enable researchers The Cancer Division was pleased to undertake independent research to welcome the appointment of in cancer that is nationally and Professor Vanessa Hayes, from the internationally competitive. J. Craig Venter Institute in San Diego, Dr David Gallego-Ortega, leader of the USA, to the University of Sydney/ Tumour Development Group, received a Garvan Institute Chair of Prostate $5,000 Heliflite Young Explorer Award. 2014 Garvan Thesis Prize winner, Saul Bert. Cancer Research, and Professor Neil His ultimate goal is to provide new Watkins, from Monash University, to targets for treatment and diagnosis of the Chair in Cancer Biology at Garvan. advanced breast cancer.
MASSIVE DNA MOLECULES CALLED NEOCHROMOSOMES, ARE PRESENT IN 3% OF CANCERS Garvan Institute of Medical Research · Foundation Annual Report 2014 Cancer Division
Laura Baker’s Castle Harlan Award will support her investigation into aggressive ‘basal-like’ breast cancers, for which few treatments exist.
GARVAN 15 PROMOTING ‘HEALTHY FAMILIES, GARVAN.ORG.AU HEALTHY COMMUNITIES’ IN REGIONAL AUSTRALIA Garvan and Ridley have joined forces to raise awareness about health and wellbeing in regional and rural Australia through the Healthy Families, Healthy Communities program. In 2014, Garvan and Ridley took a roadshow to communities in regional South Australia to host free public forums. There are big things to come for the Healthy Families, Healthy Communities program as it continues to: • Advocate the importance of medical research to rural and regional Australia • Share important health messages with rural and regional Australia • Convey messages supporting healthy living and risk mitigation.
GARVAN STUDENT INVITED TO ATTEND LINDAU NOBEL LAUREATES MEETING Rae-Anne Hardie, a PhD student in the Division’s Ubiquitin Signalling Laboratory was one of 15 exceptional young Australian scientists selected to participate in the International Day at the 64th Lindau Nobel Laureates Meeting in Germany. Rae-Anne went through a rigorous selection process with the Australian Academy of Science to attend the meeting. Rae-Anne’s research focuses on how the metabolism of cancer cells is regulated. After attending the Lindau GARVAN AND THE LOVE YOUR Nobel Laureates Meeting, Rae-Anne SISTER CAMPAIGN felt inspired that, through hard work and Samuel and Connie Johnson’s campaign, Love pursuing her ideas, she could achieve Your Sister (formed after Connie’s terminal great things. breast cancer diagnosis) aimed to set a new world record for the longest distance travelled on a unicycle, raise $1 million for breast cancer research and spread Connie’s message of awareness – “Don’t fall into the booby trap. Be breast aware!” In February 2014, Samuel finished his amazing 15,478 km journey around Australia on a unicycle to set a new world record. So great was the support he received that, by December 2014, Love Your Sister had doubled its fundraising target, raising $2 million to support Garvan’s breast cancer research. We very much look forward to working with
Garvan Institute of Medical Research · Foundation Annual Report 2014 Cancer Division Love Your Sister in 2015 and beyond, as together we strive towards the same goal – ensuring that no other young mum has to lose her life to breast cancer. Samuel and Connie Johnson.
16 GENEROUS GRANT FROM NBCF KICK STARTS BREAST CANCER RESEARCH FROM A NEW ANGLE A major grant from the National renewed in 2014 to support and clinicians from Princess Breast Cancer Foundation a novel and multidisciplinary Alexandra Hospital, to work to GARVAN.ORG.AU (NBCF) has enabled Professor research group, which includes identify epigenetic biomarkers Susan Clark to explore a new researchers from Garvan, for early detection and prognosis approach to breast cancer Universities of Newcastle and of triple negative breast cancer. research. NBCF’s grant, $5 Queensland, the Olivia Newton- million over 5 years, was John Cancer Research Institute
OUR RESEARCH LABORATORIES
CANCER BIOLOGY CLINICAL TRANSLATIONAL EPIGENETICS / GENOMICS RESEARCH PROGRAM RESEARCH PROGRAM RESEARCH PROGRAM Coordinated by Professor Coordinated by Dr Alex Swarbrick Coordinated by Professor Chris Ormandy and Professor Sandra O’Toole Susan Clark
Laboratories Laboratories Laboratories Cancer Biology Colon and Lung Cancer Research Epigenetics Research Laboratory Head, Professor Laboratory Head, Associate Laboratory Head, Professor Chris Ormandy Professor Maija Kohonen-Corish Susan Clark Cancer Developmental Biology Genomic Cancer Medicine Genome Informatics Laboratory Head, Professor Neil Laboratory Head, Professor David Laboratory Head, Associate Watkins (Petre Foundation Chair Thomas (commenced June 2014) Professor Marcel Dinger of Cancer Biology) Ovarian Cancer Research Human Comparative and Cell Division Laboratory Head, Dr Goli Samimi Prostate Cancer Genomics Laboratory Head, Pancreatic Cancer Research Laboratory Head, Professor Vanessa Dr Andrew Burgess Laboratory Head, Professor Hayes, (Petre Foundation Chair of Invasion and Metastasis Andrew Biankin Prostate Cancer Research) Laboratory Head, Dr Paul Timpson Pancreatic Tumourigenesis Transcriptomic Research Ubiquitin Signalling Laboratory Head, Dr Ilse Rooman Laboratory Head, Dr Timothy Mercer Laboratory Head, Dr Darren Saunders Tumour Progression Groups Laboratory Head, Dr Alex Swarbrick Groups Biodata Visualisation Breast Cancer Biology Groups Group Leader, Dr Sean O’Donoghue Group Leader, Dr Georgina Hollway Cancer Bioinformatics Chromatin Dynamics Cell Survival Group Leader, Dr Jianmin Wu Group Leader, Dr Phillippa Taberlay Group Leader, Dr Samantha Oakes Clinical Prostate Cancer Research Epigenetic Deregulation Genome Evolution Group Leader, Associate Professor Group Leader, Dr Clare Stirzaker Group Leader, Professor Lisa Horvath Histone Variants Richard Epstein Functional Oncogenomics Group Leader, Dr Fatima Valdes-Mora Network Biology Group Leader, Dr Tim Molloy Group Leader, Dr David Croucher Hormones and Cancer (commenced March 2014) Group Leader, Dr Ann McCormack Replication and Genome Stability Personalised Cancer Therapeutics Group Leader, Dr Liz Caldon Group Leader, Dr Marina Pajic Tumour Development Translational Breast Group Leader, Dr David Gallego-Ortega Cancer Research Tumourkine Group Leader, Professor Group Leader, Associate Professor Sandra O’Toole Graham Robertson Wnt Signalling Group Leader, Dr Laurent Pangon 210 Garvan Institute of Medical Research · Foundation Annual Report 2014 Cancer Division STAFF AND STUDENTS
GARVAN 17 GARVAN.ORG.AU DIABETES AND METABOLISM Professor Gregory Cooney Acting Division Head
WHAT WE DO RESEARCH HIGHLIGHTS because its high energy-burning capacity makes it a potential target Type 2 diabetes affects 7 per cent of Genetics detective work pinpoints for developing therapies to treat the Australian population and there are novel diabetes mutation obesity and diabetes. currently more than 200 million people Professor Lesley Campbell AM, and worldwide with this disease. Without her collaborators at the University of How keeping cool could spur any intervention, the incidence of Cambridge identified a novel genetic metabolic benefits diabetes is predicted to increase at a mutation underlying puzzling diabetes significant rate. Another study by Dr Paul Lee symptoms in two families suffering demonstrates that ambient Our Division contributes to the global from lipodystrophy, a rare disorder temperature can influence the effort to understand the causal associated with metabolic syndrome. amount of brown fat in people. relationships between genetics, the The diabetes and lipid disorders in Cool environments stimulate environment and the development these patients were poorly controlled deposition of brown fat while of type 2 diabetes. We work to by insulin but gastric bypass surgery warm environments promote loss. understand the circumstances under had a remarkably beneficial effect. It is which obesity precipitates pancreatic Heightened insulin sensitivity was probable that the gut hormone GLP1, dysfunction and diabetes to enable the among the metabolic benefits of which creates a feeling of fullness prediction, prevention and treatment increased brown fat suggesting after a meal, had increased in these of metabolic disease. that people with more brown fat patients after surgery and helped them require less insulin after a meal to The new whole genome sequencing lose weight as well as improve their bring their blood sugar levels down. capabilities at Garvan enhance our diabetic symptoms. These findings open up new ability to identify genetic variations The researchers identified a novel avenues for the treatment of in patients with diabetes and identify mutation in the perilipin-1 gene impaired glucose metabolism. specific forms of diabetes for further which affects the storage of fats in research and develop personalised fat cells. Discovery of the genetic Scientists create new food additive medicine approaches for diagnosis mutation can help clinicians identify to reduce hunger and treatment. new courses of effective treatment Associate Professor Alexander Viardot, We have eight laboratories with more for people with diabetes. together with a group of collaborators than 40 staff working on basic science at Imperial College London, has and clinical research projects. Evidence that shivering and exercise developed a new food additive may convert white fat to brown Further information and staff profiles designed to make people feel fuller. are available at Endocrinologist Dr Paul Lee uncovered Their studies show the additive is how fat and muscle communicate with effective at preventing weight gain in garvan.org.au/research/diabetes-
each other through specific hormones overweight people. metabolism – turning white fat cells into brown fat The additive combines inulin,
cells to protect us against cold. a naturally occurring fibre, with Garvan Institute of Medical Research · Foundation Annual Report 2014 Diabetes and Metabolism Division His research suggests that shivering propionate, a normal by-product We work to understand the “ and bouts of moderate exercise are of fibre fermentation by intestinal circumstances under which obesity equally capable of stimulating the bacteria, and delivers much larger precipitates pancreatic dysfunction conversion of energy-storing ‘white quantities of propionate than can and diabetes to enable the fat’ into energy-burning ‘brown fat’. be acquired with a normal diet. “prediction, prevention and treatment This increased propionate stimulates Interest in brown fat has risen of metabolic disease. the gut to release hormones that act significantly over the last few years on the brain to reduce hunger.
18 GARVAN.ORG.AU
40STAFF AND David Gonski, Chancellor of UNSW, and Professor Ted Kraegen at his DSc ceremony. STUDENTS
A NEW FOOD ADDITIVE IS A NEW LEADER FOR THE DIVISION EFFECTIVE AT PREVENTING The Division has recruited Professor Mark Febbraio, an internationally renowned WEIGHT GAIN IN scientist, to lead the Division from 2015 and head the Cellular and Molecular Metabolism OVERWEIGHT PEOPLE Laboratory. Professor Febbraio comes to us from the Baker IDI Heart and Diabetes Institute in Melbourne where his research has focused on understanding cellular and molecular mechanisms associated with obesity and type 2 diabetes. MOTHER AND SON’S SHARED PASSION Acting Head of the Division, Professor SUPPORTS DIABETES AND OBESITY RESEARCH Gregory Cooney said, “It’s been an exciting year for the Diabetes and Lysia O’Keefe had walked past Garvan many times, Metabolism Division. Engaging Professor before deciding to come in and find out about our Febbraio is a great achievement for research. Lysia, previously a nurse with Garvan as a whole. I’m looking forward St Vincent’s Hospital, has long been passionate to our Division going to great new about understanding the global epidemic of obesity heights under his leadership.” and type 2 diabetes. An interest she shares with son Ben, a pilot who may have pursued a career as a doctor if not for his love of travel and adventure. Dr Dorit Samocha-Bonet is the leader of the Clinical Insulin Resistance group under the direction of Associate Professor Jerry Greenfield. With Lysia and Ben’s support, Dr Samocha-Bonet is running a clinical study to understand why some clinically obese people are metabolically healthy, and some are unhealthy. Without Lysia and Ben’s philanthropic support, the clinical study may not have come to fruition. BROWN FAT BURNS ENERGY WHILE WHITE FAT Garvan Institute of Medical Research · Foundation Annual Report 2014 Diabetes and Metabolism Division STORES ENERGY
Lysia O’Keefe and her son Ben.
GARVAN 19 GARVAN.ORG.AU WORKING WITH ZEBRAFISH TO UNDERSTAND THE PANCREAS Dr Daniel Hesselson, head of the Beta In one project Dr Hesselson creates In another study, Dr Hesselson is Cell Regeneration Laboratory at Garvan, diabetic zebrafish by experimentally investigating methods to reprogram uses zebrafish to study diabetes. removing insulin-producing beta cells other cells in the pancreas to develop Zebrafish are an excellent experimental from the pancreas and then studies into insulin-producing beta cells. If such model since they are vertebrates and how loss of these cells influences reprogramming could be achieved in thus have a similar basic anatomical the functioning of other organ the human pancreas it would be an structure to humans; they are easy systems. His work has identified a effective way to treat type I diabetes to keep in very large numbers for potential link between diabetes and without the need for beta cell/ experimentation; their embryos Parkinson’s disease and he can now pancreatic islet transplantation. are transparent so developmental test existing drugs to see if they processes are readily visualised; and alleviate the symptoms. drug-testing simply involves addition of the drugs to the tank water.
AWARD AND Insulin Signalling RECOGNITION HIGHLIGHTS Laboratory Head, Dr Carsten Schmitz-Peiffer A Doctor of Science (DSc) was awarded to Professor Ted Kraegen by UNSW Islet Biology Australia in recognition of his extensive Laboratory Head, Associate Professor work in type 2 diabetes. Ross Laybutt Molecular Metabolism Professor Lesley Campbell AM Laboratory Head, Professor received the Sir Kempson Maddox Greg Cooney Award from Diabetes NSW. The award is the highest honour Diabetes NSW Phospholipid and Cell Biology can bestow and recognises Professor Laboratory Head, Dr Will Hughes Campbell’s significant contribution to scientific research, education and Groups advocacy in diabetes. Adipose Tissue Function Dr Daniel Hesselson inspecting his zebrafish. in Obesity OUR RESEARCH LABORATORIES Group Leader, Dr Michael Swarbrick AND GROUPS (until October 2014) CONFOCAL MICROSCOPY Clinical Insulin Resistance Laboratories Microscopy, in its many forms, is Group Leader, Dr Dorit Adipose Tissue in Diabetes one of Garvan’s major capabilities. Samocha-Bonet and Obesity We have a dedicated Microscopy Laboratory Head, Professor Personalised Medicine in Facility within The Kinghorn Cancer Katherine Samaras Diabetes Care Centre and various microscopes Group Leader, Dr Alex Viardot Beta Cell Regeneration throughout Garvan to provide Laboratory Head, researchers with access to many Dr Daniel Hesselson state-of-the-art imaging techniques. Beta Cell Signalling Confocal microscopy is an optical Laboratory Head, Professor imaging technique which helps us Trevor Biden define where specific molecules Cellular Systems Biology are located within cells. Microscopy Laboratory Head, Professor David is useful for understanding how James (until September 2014) disease causing mutations affect the location of particular molecules Clinical Diabetes, Appetite and helps explain how mutations and Metabolism contribute to abnormal cell function Laboratory Heads, Professor Lesley and lead to disease. Campbell AM and Associate Professor Jerry Greenfield Confocal microscopy works by Garvan Institute of Medical Research · Foundation Annual Report 2014 Diabetes and Metabolism Division imaging only a thin slice of a sample, Diabetes and Metabolism resulting in a particularly clear and Laboratory Head, Professor Ted Kraegan high resolution image. By imaging (retired October 2014) Confocal microscopy used to reveal immune multiple slices of a sample, a three cells (green) invading and surrounding a Fat and Insulin Resistance dimensional representation of the cluster (islet) of insulin producing cells (red) in Laboratory Head, Professor Don Chisolm sample can be built. AO (retired December 2014) the pancreas.
20 Young Garvan GARVAN.ORG.AU Supports Early Career Researchers
Young Garvan was established in 2003 by a volunteer Young Garvan Award group of young supporters who help fundraise and raise In 2014, Dr Daniel Hesselson, Head of the awareness for the Garvan Institute. Young Garvan aims Beta Cell Regeneration Laboratory2014 in the to educate and inform younger generations about the Diabetes and Metabolism Division, was the importance of medical research and its social and ethical winner of the Young Garvan Award for his impacts on society, and to build a greater awareness and research project using zebrafish to identify regard for medical research. genes or drugs that might impede the Each year, Young Garvan hosts the All Ribbons Ball progression of age-related diseases. and also organises three public forums on a variety of topical areas. In 2014 the forum topics were: Young Garvan Special Initiative Grants 1Generation G: The genomic revolution Young Garvan Special Initiative Grants were and what it means awarded to Dr Guy Barry, the Human Brain 2Evolution of a cure Transcriptomics Group Leader, and Dr Nicole East meets West Schönrock, a Senior Research Officer in the 3 RNA Biology and Plasticity Laboratory. Dr Barry will test his theory whereby experience and stress-related changes THE AWARD occurring in the human brain are inherited by the next generation. The Young Garvan committee supports outstanding young investigators to undertake innovative, high risk Dr Schönrock will be using her award projects and test new ideas. The Young Garvan Award to sequence and characterise two RNA and the Young Garvan Special Initiative Grants are modifications in the brain that are linked to presented to Garvan scientists at the All Ribbons Ball defects in cognitive ability. Using a combination each year. of cutting-edge experimental techniques and bioinformatics, she hopes to identify the Young Garvan Award - $50,000 RNA modification sites that cause intellectual Special Initiative Grants - $10,000 each disability when interrupted. Garvan Institute of Medical Research · Garvan Research Foundation · Annual Report 2014 · Young Garvan Garvan Institute of Medical Research · Foundation Annual Report 2014 Young
The 2014 winners (Left to Right): Dr Nicole Schönrock, Dr Daniel Hesselson and Dr Guy Barry.
GARVAN 21 GARVAN.ORG.AU IMMUNOLOGY Professor Robert Brink Division Head
WHAT WE DO RESEARCH HIGHLIGHTS TECHNOLOGY DEVELOPMENTS The immune system protects the body Slowing down the immune system Introducing genetic mutations in mice from dangerous attacks, whether they when in overdrive Professor Robert Brink utilised come from outside as infections, or Finding ways to alleviate the chronic the Division’s genetic engineering inside as cancer. It also differentiates inflammation many people endure capabilities to introduce a revolutionary between actual threats to the body, as a result of their immune systems new gene-editing technology (CRISPR/ healthy cells and molecules; when overreacting to “self” tissue was a Cas9) to create genetically modified this process fails, autoimmune major research focus for Garvan’s mice and zebrafish to study human diseases occur and the body attacks immunology researchers. disease. Developed in the US, this its own tissue. technology dramatically reduces the Associate Professor Cecile King and Our Division wants to understand how average time from pin pointing a target Dr Alexis Vogelzang, working with our immune system functions to protect genetic mutation in human studies, bioinformatics experts Drs Marcel the body, how this goes wrong and how to testing it in a mouse model in the Dinger and Brian Gloss, confirmed how it could be prevented or treated. laboratory. What used to take two years a small molecule known as Interleukin now only takes two months, and can be We are studying the role of the immune 21 (IL-21) contributes to inflammation, completed at a greatly reduced cost. system in a range of diseases: type 1 including some fatal inflammatory diabetes, type 2 diabetes, gestational conditions. The researchers were able to This means target genes identified diabetes, cancer, multiple sclerosis, subdue inflammation by experimentally through whole genome sequencing in asthma, lupus, rheumatoid arthritis and blocking IL-21. clinical genomics studies can quickly be Sjögren’s syndrome. tested in mice for an association with In future research, the team aims to the disease, and for testing drugs that We have 10 laboratories in the determine whether drugs can be used may alleviate the disease. Division with 91 staff and students. to block IL-21 and thus provide major More information and staff profiles health benefits for individuals suffering Breakthroughs in engineering are available at from chronic inflammation. stable antibody drugs garvan.org.au/research/immunology Unsuspected aspect of immune The Antibody Therapeutics Laboratory,
regulation revealed led by Associate Professor Daniel Christ, has developed novel technologies that
Associate Professor Shane Grey and improve the stability of therapeutic Senior Research Assistant Stacey monoclonal antibodies. Monoclonal Walters have uncovered a new role for “ antibody drugs are a major class of B cells. They showed that, in addition to therapeutics used in the treatment of making antibodies, B cells participate in I have always believed that if you diseases such as rheumatoid arthritis, the development of regulatory T cells. want to give where it will do the multiple sclerosis and cancer. most good, give to the future – that’s Several studies (including previously Many monoclonal antibody drugs under why we give to medical research. published data by Grey and Walters)
Garvan Institute of Medical Research · Foundation Annual Report 2014 Immunology Division development by the pharmaceutical “ have shown that high levels of The late Mrs Patricia Ritchie AM industry have problems with stability regulatory T cells can prevent organ during manufacture, storage and rejection. This novel finding opens up a delivery. Many fail to go to market new avenue of research to see whether because of these issues. B cells may have a role in preventing organ rejection, as well as controlling a This technology is now being number of autoimmune conditions. commercialised with support from the Medical Research Commercialisation Fund, through a spin-off company, 22 Solvanix, to launch in early 2015. THE ANSTO EUREKA PRIZE FOR INNOVATIVE USE OF TECHNOLOGY GARVAN.ORG.AU Dr Tri Phan, head of the Division’s Intravital Microscopy Unit was awarded the 2014 ANSTO Eureka Prize for Innovative Use of Technology. Together with Dr Steve Lee from ANU he developed a simple and cheap way of making a ‘DIY droplet lens’ the size of a lentil, which enables 160 times magnification when placed over the camera lens of a smartphone. 91STAFF AND STUDENTS
THANK YOU TO THE BILL AND PATRICIA RITCHIE FOUNDATION “I have always believed that if you want to give where it will do the most good, give to the future – that’s why we give to medical research.” – The late Mrs Patricia Ritchie AM. Dr Tri Phan and his collaborator Dr Steve Lee. The Bill and Patricia Ritchie Foundation has been a highly valued supporter of Garvan for more than 20 years. Mrs Ritchie first heard about the organisation through a seminar MANY MONOCLONAL series and after speaking with Professor John Shine, she then established The Bill Ritchie ANTIBODY DRUGS UNDER Post-Doctoral Research Fellowship, which has supported many important research careers in DEVELOPMENT BY THE their early stages. In March 2014, The Bill and Patricia Ritchie PHARMACEUTICAL Chair was established at Garvan by The Bill and Patricia Ritchie Foundation which enabled INDUSTRY HAVE PROBLEMS us to recruit the renowned immunologist, Professor Chris Goodnow, as Deputy Director WITH STABILITY of the Institute. The longevity of the association between Garvan and The Bill and Patricia Ritchie Foundation is a source of great pride to the entire family.
UNSTABLE VS STABLE ANTIBODIES
Unstable antibodies stick together as aggregates and make Garvan Institute of Medical Research · Foundation Annual Report 2014 Immunology Division the buffer cloudy (left) while stable antibodies are much more soluble and the buffer solution is clear (right). The late Mr Bill Ritchie and the late Mrs Patricia Ritchie AM.
GARVAN 23 AWARD AND OUR RESEARCH LABORATORIES RECOGNITION HIGHLIGHTS AND GROUPS FLOW CYTOMETRY GARVAN.ORG.AU The Division recruited renowned Laboratories Using fluorescently labelled tags immunologist and molecular Antibody Engineering (usually antibodies) to identify cell geneticist, Professor Chris Goodnow Laboratory Head, Associate Professor surface proteins, flow cytometry to join Garvan in 2015 to establish Daniel Christ can identify cellular subpopulations an Immunogenomics Laboratory. B Cell Biology in even the most complex mixture Professor Goodnow will assume The Laboratory Head, Professor of cell types. Immunologists Bill and Patricia Ritchie Foundation Robert Brink have long used flow cytometry Chair, established by a generous and cell sorting to understand Cellular Immunity donation from The Bill and Patricia the complexities of the immune Laboratory Head, Professor Jonathon Ritchie Foundation, and will also be response. These techniques have Sprent FRS FAA Deputy Director of Garvan. identified new and important Diabetes and Transcription Factors Professor Jonathon Sprent, leader cells responsible for the normal Laboratory Head, Professor of the Cellular Immunity Laboratory functioning of the body’s immune Jenny Gunton and Professor Chris Goodnow were system as well as cells responsible awarded Senior Principal Research Immunobiology of Cytokines for disease. Laboratory Head, Dr Marcel Batten Fellowship funding for the next five Flow cytometry is now also used years by the NHMRC. The Sprent Immunology and Immunodeficiency to detect rare cancer cells in Laboratory is working on three Laboratory Head, Associate Professor the bloodstream of patients for promising immunotherapies with the Stuart Tangye monitoring cancer progression, ultimate goal of making them safe for Innate and Tumour Immunology as well as identifying the very use in people. Professor Goodnow is Laboratory Head, Dr Tatyana Chtanova few cancer stem cells present zooming into whole human genomes, Intravital Microscopy in a mixture of cell types in adjusting his focus at the level of single Laboratory Head, Dr Tri Phan tumours. Recent breakthroughs nucleotide change, and relating change in the ability to sequence the Mucosal Autoimmunity back to disease. entire genome through single cell Laboratory Head, Associate Professor genomics techniques promise Professor Jenny Gunton, head of the Cecile King Division’s Diabetes and Transcription to fundamentally reshape our Transplantation Immunology Factors Laboratory for many years, took understanding of the evolution of Laboratory Head, Associate Professor up the position of Head of the new many diseases at the cellular level, Shane Grey Centre for Diabetes Research (CODR) including cancer. at Westmead Hospital as Professor of Medicine. Professor Gunton will Groups continue to collaborate with Garvan, Genomic Engineering furthering our critical links with hospitals Group Leader, Dr David Zahra and patients. Human Immune Disorders Group Leader, Dr Cindy Ma Immune Cell Migration Group Leader, Dr Dominique Hess Immune Immunovirology Group Leader, Dr Umamainthan Palendira (until January 2014) Immune Tolerance Group Leader, Dr Kylie Webster Immunopathology Group Leader, Associate Professor William Sewell Lymphocyte Signalling and Activation Group Leader, Dr Elissa Deenick T Cell Homeostasis Group Leader, Dr Jae-Ho Cho (until January 2014) Garvan Institute of Medical Research · Foundation Annual Report 2014 Immunology Division
Multicolor Flow Cytometry analysis of human peripheral blood to analyse subpopulations of T Cells. Individual cellular subpopulations were then isolated to determine their molecular properties.
24 2014 Ovarian Cancer Awareness GARVAN.ORG.AU Day Leaders’ Lunch
For the third year, Garvan marked Ovarian Cancer Awareness Day with a gathering of those working toward improving outcomes for women diagnosed with this devastating disease. The response to the 2014 Ovarian Cancer Awareness Day Leaders’ Lunch was overwhelming, with the Strangers Dining Room at NSW Parliament House at capacity. The event was hosted by The Hon Jillian Skinner MP, Minister for Health and Minister for Medical Research, and Mrs Margaret Rose AM, business leader, ovarian cancer survivor and dedicated advocate for Garvan’s Ovarian Cancer Research Program. It encouraged support for Garvan’s ovarian cancer research, raised awareness about the disease Mrs Margaret Rose AM (centre) and her daughters and acknowledged Mrs Rose’s outstanding support. Sacha Rose Calligeros (left) and Marisa Campion (right).
The MLC Community Foundation And more than half a century of history
It was his daughter, Mrs Helen Mills, who generously donated a leadership gift of £100,000 in 1961 to establish the Garvan Institute of Medical Research (officially opened in 1963). In recent years the MLC Community Foundation has contributed more than $1.3 The MLC Community Foundation and Garvan million to Garvan’s breakthrough medical enjoy a historical link and a shared mission – research. Most recently, MLC Community to improve the health of our community. Foundation invested significantly in a novel Garvan Institute of Medical Research · Garvan Research Foundation · Annual Report 2014 · Ovarian Cancer Awareness · MLC Community Foundation Garvan Institute of Medical Research · Foundation Annual Report 2014 Ovarian Cancer Awareness The Mutual Life and Citizens’ Life Assurance study into mood disorders and schizophrenia. Co. (formerly Citizens’ Assurance Co) was Together, Garvan and MLC Community founded by James Patrick Garvan in 1886. Foundation hope to improve mental health outcomes for all Australians.
GARVAN 25 GARVAN.ORG.AU NEUROSCIENCE Professor Herbert Herzog Division Head
WHAT WE DO RESEARCH HIGHLIGHTS New insights into neurotransmission Our Division aims to improve How fat might be controlled Dr Greg Neely, Dr Adam Cole understanding of the molecular through our body clock and their colleagues reported the mechanisms that underpin the importance of a novel regulator Research led by Professor Herbert ability of the human brain to learn, of vesicular trafficking and Herzog has shed more light on an to think,control emotion and regulate neurotransmission in the brain, underexplored aspect of the important other critical body functions. involving the enzyme glycogen brain-signalling system that controls synthase kinase 3. This enzyme We are studying the alterations in appetite, body composition and is known to function as a master neuronal systems associated with energy use. regulator of the development and disorders such as schizophrenia, This work has identified that a specific function of the nervous system. neurodegenerative disorders such as gene regulating our body clock may Parkinson’s disease and Alzheimer’s The findings have implications for play a central role in determining how disease, hearing loss and chronic pain. conditions such as bipolar disorder much fat is stored on our body and We also study the regulation of energy and Alzheimer’s disease, in which how much lean tissue is maintained balance (intake and expenditure), neurotransmission is impaired. after food intake. which affects fertility, mood, weight gain and physical fitness. PARK9 gene could offer therapeutic Influence of stress on appetite possibilities for Parkinson’s disease The brain has an enormous capacity and ‘fat gain’ to change neural connectivity αSynuclein is a protein involved in Chronic stress may not only increase throughout life by a phenomenon Parkinson’s disease. When αSynuclein our appetite and lead us to overeat, called neuroplasticity that is involved does not fold properly inside a but can also cause the body to store in learning, thinking and repair nerve cell (neuron) it becomes toxic more of our calorie intake as fat than after injury. Our researchers are and contributes to the neuron’s under normal conditions. exploring how neuroplasticity might degeneration. Toxic αSynuclein can be be epigenetically regulated through Professor Herbert Herzog and exported out of these failing neurons chemical modification of DNA colleagues have found that this where it has the potential to interact sequences and the action of ‘fat gain’ is due to the action of the with neighbouring healthy neurons and non-coding RNAs, processes that stress hormone neuropeptide Y (NPY), trigger them to also start degenerating. can be influenced by external a signalling molecule produced in the This “spreading” of toxic αSynuclein factors such as stress and trauma. brain. NPY is a key area of study for from one neuron to another neuron the Division because many of the is an attractive model to explain how We have more than 66 staff and molecules that regulate appetite disease progresses from one brain students working across seven
and body weight do so via interaction region to another. laboratories. Further information with the complex system of NPY and and staff profiles are available at Associate Professor Antony Cooper
its Y-receptors. and collaborators have demonstrated garvan.org.au/research/neuroscience that PARK9, a gene known to be Garvan Institute of Medical Research · Foundation Annual Report 2014 Neuroscience Division “ associated with Parkinson’s disease, The brain has an enormous capacity contributes to the export of αSynuclein to change neural connectivity from degenerating neurons. These throughout life by a phenomenon findings raise the prospect that called neuroplasticity that is involved in neurodegeneration in Parkinson’s disease “learning, thinking and repair after injury. patients might be reduced by modulating PARK9 levels, with therapeutic benefits.
26 FRUIT FLIES ASSIST IN THE STUDY OF DISEASE Drosophila melanogaster, commonly known as the fruit fly, has been used by scientists for more than
100 years as a model to unravel the genetic basis of GARVAN.ORG.AU DR NICOLE SCHÖNROCK USED development and disease. THE CHAMP YOUNG PIONEER Scientists sequenced the entire fruit fly genome in AWARD TO PROGRESS 2001 and showed that flies and humans have many genes in common. Humans in fact share 75 per HER RESEARCH. SHE IS cent of their disease-causing genes with the fruit TRYING TO UNDERSTAND fly, making Drosophila a valuable organism to help THE “LANGUAGE” OF RNA study human disease and develop therapeutics. MOLECULES – THAT IS, Dr Greg Neely’s Laboratory in the Neuroscience Division is using fruit flies to screen for genes HOW THEY REGULATE THE involved in a number of disorders, including heart BIOLOGICAL PROCESSES THAT function, pain perception, neurodegeneration, lifespan and metabolic disorders, kidney function MAKE OUR BODIES FUNCTION. and cancer. The aim is to identify new genes that may be viable drug targets.
Fruit flies feeding.
HELIFLITE YOUNG EXPLORER AWARD Dr Martin Smith focuses on the functional characterisation of non-protein coding regions in the human genome (98 per cent of all DNA). The Heliflite Young Explorer Award funded STAFF AND66 STUDENTS his travel to Quebec City, Canada where he presented to 800 international delegates at the annual RNA Society Meeting. SEMINAR EXPLAINS SOME DISEASES AFFECTING HEALTHY AGEING As we live longer, knowing how to remain healthy as we age is vital. In August, the Garvan Research Foundation hosted a free public seminar, Healthy ageing: Diseases that affect us as we age. The seminar provided an opportunity for 300 members of the public to hear from some of Garvan’s leading neuroscience researchers including: • Dr Guy Barry
Diseases of the brain and the role Garvan Institute of Medical Research · Foundation Annual Report 2014 Neuroscience Division of genome sequencing
Dr Martin Smith, Dr David Gallego-Ortega with Heliflite’s Lyndsay and Scott • Associate Professor Antony Cooper Edmonds and Garvan’s Head of Corporate Partnerships Leonie Walton. Parkinson’s disease • Professor David Ryugo Hearing loss
GARVAN 27 GARVAN.ORG.AU AWARD AND OUR RESEARCH LABORATORIES RECOGNITION HIGHLIGHTS AND GROUPS THANK YOU TO THE ROTH Dr Martin Smith, a Bioinformatics Laboratories CHARITABLE FOUNDATION FOR MORE THAN 20 YEARS OF Research Officer in the RNA Eating Disorders PHILANTHROPIC SUPPORT Biology and Plasticity Laboratory, Laboratory Head, Professor won the 2014 Heliflite Young Herbert Herzog The Roth Charitable Foundation Explorer Award. Supported by Functional Genomics (formerly The Henry H Roth Charitable Heliflite, a leading helicopter Laboratory Head, Dr Greg Neely Foundation) was established in 1989 distributor in Australasia, the by Henry and Ann Roth in memory of
Heliflite Young Explorer Award Hearing Henry’s father, sister and brother and Laboratory Head, Professor commenced in 2014 and enables the other 6 million Jews who were David Ryugo young researchers to attend murdered in the Holocaust. international conferences or engage Neurodegenerative Diseases in international collaborations Laboratory Head, Dr Bryce Vissel Garvan’s relationship with the Roth Charitable Foundation began in 1994, supported by a $5,000 grant. Neuronal Stem Cells when Henry’s sons, John and Stanley, Laboratory Head, Professor John Dr Nicole Schönrock, a Senior expanded the Foundation and began Shine AO FAA Research Officer in the RNA their support of medical research at Biology and Plasticity Laboratory Parkinson’s Disease Garvan with a particular interest in won the 2014 CHAMP Young and Neurogenomics dementia and Parkinson’s disease. Pioneer Award. Initiated by CHAMP Laboratory Head, Associate Private Equity in 2014, the award Professor Antony Cooper In 2014, the Roth Charitable Foundation became a Garvan provides $10,000 to support an RNA Biology and Plasticity “Life Governor” and renewed its early career researcher to facilitate Laboratory Head, Professor John support with the establishment of the an innovative research proposal. Mattick AO FAA Roth Foundation Fellowship, which Jackie Lau and Louise Cottle, third is currently supporting Dr Bryce year PhD students in the Division’s Groups Vissel, head of the Neurodegenerative Eating Disorders Laboratory Energy Expenditure Diseases Laboratory at Garvan. and Parkinson’s disease and Group Leader, Dr Lei Zhang The generous and long standing Neurodegeneration Laboratory, Human Brain Transcriptomics respectively – received the 2014 support of the Roth Charitable Group Leader, Dr Guy Barry Foundation has been transformative Stuart Furler Travel Awards. (since August 2014) This award was established in in the study of neurodegenerative
memory of Stuart Furler, a long- Neuroanatomy diseases at Garvan. The research Group Leader, Dr Shu Lin serving and highly regarded Garvan findings we make today will improve scientist, by his family. The award Neuroendocrinology the health outcomes of tomorrow. is open to third year PhD students Group Leader, Dr Yanchuan Shi and supports them to attend major Neurosignalling and international conferences in their Mood Disorders UNCONVENTIONAL PATHWAYS field with a $5,000 grant. Group Leader, Dr Adam Cole INVOLVED IN SCHIZOPHRENIA (until August 2014) Honours recognise Long-coding RNAs (lncRNAs) play Professor John Mattick’s a central role in the epigenetic ground-breaking contributions regulation of brain function. Dr Guy Professor John Mattick was named Barry, Professor John Mattick and as one of the all-time high achievers colleagues from the University of in Australian health and medical Queensland, RIKEN (Japan) and research by the National Health John Hopkins (USA), have shown and Medical Research Council that Gomafu is one of the lncRNAs (NHMRC). differentially expressed during neuronal activation in the brain and Professor Mattick was also is involved in alterations to gene honoured with the with the expression seen in schizophrenia. University of Texas MD Anderson These studies suggest that lncRNAs Cancer Center 2014 Ernst W Garvan Institute of Medical Research · Foundation Annual Report 2014 Neuroscience Division may be novel targets for therapeutic Bertner Memorial Award, which is development to treat neurological conferred on a physician or scientist disorders such as schizophrenia. who has made distinguished contributions to cancer research. PhD students Louise Cottle and Jackie Lau, winners of the 2014 Stuart Furler Travel Award.
28 Spectacular GARVAN.ORG.AU Biomedical Animations
Dr Kate Patterson, a Senior Research Officer specialising in scientific animation, premiered her biomedical animation “Cancer is Not One Disease” at Melbourne’s Deakin Edge Theatre in April. Dr Patterson is one of three scientist-animators in the Inspiring Australia-funded “VIZBIplus–Visualising the Future of Biomedicine” project. Using three- dimensional animation software, her spectacular animation highlights the role of the tumour suppressor protein p53, known as “the guardian of the genome”, in the formation of many cancer types. VIZBIplus aims to create awe-inspiring and scientifically accurate 3D animations which explain the latest medical research in a way that engages and educates a general audience. Kate Patterson’s p53 animation.
Website Redesign
To commemorate Garvan’s 50th anniversary, in January 2014, we relaunched the website with a fresh design, enhanced navigation and increased quality and quantity of content. Website traffic more than doubled in 2014 and we succeeded in integrating the site more fully with our social media channels, Garvan Institute of Medical Research · Garvan Research Foundation · Annual Report 2014 · Spectacular Biomedical Animations · Website Redesign Garvan Institute of Medical Research · Foundation Annual Report 2014 Spectacular Biomedical Animations Website which include Facebook, Twitter, LinkedIn and YouTube.
GARVAN.ORG.AU
GARVAN 29 GARVAN.ORG.AU KINGHORN CENTRE FOR CLINICAL GENOMICS Associate Professor Marcel Dinger
WHAT WE DO To streamline Australian researchers’ Funding for Sydney Genomic access to whole human genome Collaborative Program The Kinghorn Centre for Clinical sequencing technology, KCCG has Genomics (KCCG) was established In June 2014, the NSW government formed a partnership with BioPlatforms in 2012 with a small team, but a big announced a new Sydney Genomic Australia partners: the Australian vision to advance genome research Collaborative program, backed by Genome Research Facility and the and integrate genomics into patient $24 million in funding, placing NSW Ramaciotti Centre for Genomics. diagnosis and treatment – what at the forefront of medical genomics We work with research, health and
we now call precision medicine. in Australia. commercial organisations to improve We have been extremely pleased the interpretation of genomes and
to have had such strong support genome variants and assess their The Sydney Genomic Collaborative from The Kinghorn Foundation, the clinical utility. Program is the most exciting new NSW government and our many venture I’ve seen in my time as “ collaborators, to establish the 2014 HIGHLIGHTS Minister for Medical Research. infrastructure and expertise to achieve “Sequencing of large cohorts of patients this vision. The Centre now has Next generation genome has the potential to unleash amazing more than 30 staff and has become sequencing system acquired improvement in health and efficiencies Australia’s first purpose-built facility and installed in health spending. for undertaking affordable large-scale Just over a decade ago it cost more than genomic research projects and clinical- Jillian Skinner, NSW Minister for Health a billion dollars to sequence the first grade genomic sequencing. and Minister for Medical Research. human genome. In January 2014, Garvan The complete DNA sequence of an acquired the revolutionary Illumina HiSeq The funding will support the Genomic individual is powerful information from X Ten Sequencing System, providing Cancer Medicine program at The which to explore the genetic basis of KCCG with immensely powerful genome Kinghorn Cancer Centre ($7 million health and disease. If we sequence sequencing potential and the capability - see the Cancer Division section of many individuals in a population - to sequence up to 18,000 whole human this report), a $10 million Medical those with particular diseases and genomes per year at a base cost of Genomics Reference Bank; and whole also those who are healthy - we will US$1000 per genome. genome sequencing for a suite of NSW gain vast knowledge on which genes This acquisition was made possible by Health Collaborative Genomic Medical are causative in disease. We will also the generous support of The Kinghorn Research Grants ($7 million over three gain insight into which genes place an Foundation and has established years). individual at risk for disease or protect Garvan as the national leader in from disease. This knowledge will The Medical Genomics Reference sequencing capability. Garvan Institute of Medical Research · Foundation Annual Report 2014 Kinghorn Centre for Clinical Genomics ultimately transform clinical practice. Bank is a particularly important project as it will contain approximately 4000 We now have the capacity and whole genome sequences from capability within KCCG to undertake healthy older Australians to be used collaborative studies with clinical for control purposes in disease- scientists on a range of medical specific genomic research. This world- conditions including cardiac disease, first initiative will assist researchers head and neck cancers, kidney disease to identify clinically significant genetic and diabetes. variations in their cohorts. 30 GARVAN.ORG.AU
31STAFF AND STUDENTS
Mr and Mrs John and Jill Kinghorn in The Kinghorn Cancer Centre.
The Kinghorn Foundation has not only helped Garvan to establish The Kinghorn Cancer Centre, but by founding the Kinghorn Centre for Clinical Genomics, it has helped Garvan to cement its place as a world leader in the field, with the most powerful genome sequencing facility in the Southern Hemisphere. The Kinghorn’s support, like Garvan, is motivated by the hope of better health outcomes for all Australians.
A C G T
THE COMPLETE DNA SEQUENCE OF AN INDIVIDUAL IS POWERFUL INFORMATION FROM WHICH TO EXPLORE THE GENETIC BASIS OF DISEASES. Garvan Institute of Medical Research · Foundation Annual Report 2014 Kinghorn Centre for Clinical Genomics
Scientists working with one of the Illumina HiSeq X Ten machines.
GARVAN 31 GARVAN.ORG.AU
OUR PEOPLE
KCCG has 31 staff across four primary teams: Genome Sequencing Translational Genomics For clinical genomics to benefit the David Miller joined KCCG in August Team Leader Dr Mark Cowley and Australian public as a whole, it will 2014 to lead the Genome Sequencing his staff implement systems to require the active engagement of Team, which is focused on generating apply whole genome sequencing in patients, professionals and a range large scale and high quality genomic an accredited, clinical setting. This of diverse communities. sequencing data. involves establishing sophisticated Bronwyn Terrill, Coordinator of computational pipelines to identify Public and Professional Education, Production Informatics genetic variants that underlie inherited oversees our communications and education programs. We are also Chief of Informatics, Dr Warren genetic disorders. developing a framework in the Kaplan, oversees KCCG’s high ethical, legal and societal impacts performance computing infrastructure Commercial Products of genomic medicine, guided by a and informatics implementation. His Dr Russell Howard heads the Strategic Advisory Committee. team develops clinical-grade software Commercial Strategy group that solutions to manage, analyse and is focused on translating concepts deliver large-scale genomic data sets. implemented in a research environment and developing them so that they can be adopted commercially.
FORUM TO INCREASE I have been very supportive of the Garvan UNDERSTANDING OF THE GENOME Institute’s endeavours in the field of
In April 2014, Garvan hosted Australia’s genomics and excited by the opening of this inaugural Illumina Understand Your revolutionary new field of medicine. On my
Genome education program – a two- “assessment, those attending the Understand day forum where 50 participants start Your Genome event obtained a greater insight to explore genomics by having had into the field of genomics and the impact that “ their own genome sequenced. As part this is likely to make to human wellbeing. At of this program, thought leaders from the same time, we came to learn some of the hurdles which must be overcome to enable
Garvan Institute of Medical Research · Foundation Annual Report 2014 Kinghorn Centre for Clinical Genomics policy, medicine, business, science and ethics participated in a two-day this new field of learning to gain adoption event with national and international within the medical profession… speakers and received their sequence Former Chairman of the Garvan Institute and a clinical report from Illumina’s and long-term philanthropic supporter, accredited laboratory. Mr Charles Curran AC.
32 A Lasting Legacy GARVAN.ORG.AU for Garvan
Mr and Mrs Terry and Helen Jones made the decision to include Garvan in their will after learning about Garvan’s research in 2013. Mrs Jones, a breast cancer survivor, had just been diagnosed with the beginnings of an autoimmune disease. Curious about the research that Garvan was doing into autoimmune diseases, Mr and Mrs Jones spoke with Garvan’s Professor Antony Basten, a Senior Principal Research Fellow in Garvan’s Immunology Division. The legacy that Mr and Mrs Jones will leave to Garvan will support numerous Garvan scientists to discover better ways to detect, treat and hopefully prevent autoimmune and immunological diseases. Mrs and Mr Helen and Terry Jones.
Meet an Amazing Volunteer Lynne Jones
Lynne Jones has been volunteering at Garvan for almost 15 years. A wonderful asset to both the Foundation and the Institute, Lynne splits her time between the Clinical Prostate Cancer Research group, headed by Associate Professor Lisa Horvath, and the Foundation’s Supporter Engagement team.
Over the years, Lynne has spent one day a week at Garvan Garvan Institute of Medical Research · Foundation Annual Report 2014 A Lasting Legacy Meet an Amazing Volunteer and has become a valuable member of the Garvan family. She chooses to volunteer her time as a way of contributing to the progress of medical research. Thank you to Lynne, and all of Garvan’s generous volunteers. Mrs Lynne Jones.
GARVAN 33 GARVAN.ORG.AU PHD STUDENTS Congratulations to the students receiving PhDs in 2014
Garvan has around 100 PhD students undertaking research training within the five Divisions, enrolled predominantly through UNSW Australia, but in some cases the University of Sydney. 24 of these students are international scholars coming from 21 different countries from across the globe, including China,
Mexico, Nigeria and Finland, to name just a few. Garvan is a great environment to study Some international students undertake part of their
in as it provides a number of engaging research training at Garvan and graduate from their programs aimed at getting students home university. involved. Student-run committees organise “ At Garvan we greatly value the importance of “monthly social and educational events and creating and fostering an internationally collaborative postdoctoral fellow-student mentoring environment as it is, without a doubt, a driving force programs enable students to seek relevant in the advancement of medical research. advice and learn from other’s valuable knowledge and experiences. Students at Garvan are encouraged to use initiative and think independently to become the next Laura Baker PhD student, Cancer Division generation of great medical researchers.
Congratulations to 11 of our students who were awarded PhDs from UNSW Medicine in 2014: Kerri-Lee Milner Amy Nguyen Wee Teo Supervised by Professor Don Chisholm Supervised by Professor Herbert Herzog Supervised by Dr Alex Swarbrick “Mechanisms of insulin resistance “Central regulation of body “The role of inhibitors of in chronic hepatitis C and interplay composition.” differentiation proteins Id1 and Id3 of insulin resistance, ectopic fat and in breast cancer metastasis.” Gemma Pearson adipokine release in non-alcoholic Supervised by Professor Trevor Biden Jeannette Villanueva fatty liver disease progression.” “The role(s) of lipid species in Supervised by Associate Professor Saul Bert glucose-stimulated insulin secretion Shane Grey Supervised by Professor Susan Clark from pancreatic beta-cells.” “TRAF proteins and their role in T cell Winner of the 2014 Best Thesis Prize effector function and homeostasis.” “Mechanisms of long range Yuwei Phua Amanda Wright epigenetic deregulation in Supervised by Dr Alex Swarbrick Supervised by Dr Bryce Vissel prostate cancer.” “MicroRNA-184 (miR-184) represses tumour progression by negatively “The role of AMPA receptor GluA2 Rae-Anne Hardie regulating the AKT/mTORC1 protein subunit Q/R site RNA editing Supervised by Dr Darren Saunders synthesis pathway.” in the normal and Alzheimer’s “Mitochondrial genetic variation diseased brain.” in the evolution of humans and Louise Purtell
Garvan Institute of Medical Research · Foundation Annual Report 2014 PhD Studeents metabolism of cancer.” Supervised by Professor Lesley Campbell “Genetic, endocrine, metabolic, Brian Lee immune and autonomic influences Supervised by Professor Roger Daly on energy homeostasis and “Characterisation of docetaxel- cardiovascular risk in Prader-Willi resistance in castrate resistant syndrome.” prostate cancer.”
34 GARVAN.ORG.AU Garvan Institute of Medical Research BOARD OF DIRECTORS
Executive Officer, Sydney from roles. Other positions have included 2010 to October 2013. Mr Anderson Chief of Clinical Operations and brought to the role an extensive and Chief Nursing Officer at St Vincent’s successful career in public healthcare. Hospital Melbourne, providing He has held leadership positions strategic and operational advice to the across a broad range of facilities and Hospital CEO and clinical leadership service types including tertiary referral to the Executive. Through her teaching hospitals, district hospitals, leadership of St Vincent’s Hospital sub-acute and aged care facilities. Melbourne and its partners, she has Prior experience includes two years been instrumental in the significant spent as the Executive Director of progress made towards establishing John Schubert AO St Vincent’s Public Health Service the Aikenhead Centre for Medical Chair, Nominated by the Trustees of St Vincent’s Hospital and prior to this position was the Discovery (ACMD), the first Executive Director of St Joseph’s biomedical engineering research Dr John Schubert was appointed to Hospital and St Joseph’s Village and and education centre in Australia. the Garvan Institute Board in April of the Lottie Stewart Hospital. He has Professor O’Rourke currently 2013 and appointed Garvan Chairman held other senior positions including serves as a director on the boards in May 2013. He is currently a director Rachel Forster Hospital General of St Vincent’s Institute of Medical of BHP Billiton Limited, BHP Billiton Manager; Finance and Administration Research, VESKI and the Garvan Plc and Chairman of the Great Barrier Director at Rozelle Hospital; Director Institute of Medical Research, and Reef Foundation. Until April 2013 of St Vincent’s Hospital Toowoomba; holds key roles within many other he was Chairman of the biotech and other senior positions at Central boards and committees in NSW start-up G2 Therapies Ltd and from Sydney Area Health Service. and Victoria. Professor O’Rourke 2004-2010, he was Chairman of the Mr Anderson has also had is a graduate of the Australian Commonwealth Bank of Australia, responsibility for specialised Institute of Company Directors and Deputy Managing Director from 2000- corporate roles such as the Sisters a member of the Harvard Business 2004 and a director from 1991-2000. of Charity Health Service National Club of Australia. From 2000-2003 he was a director Risk Manager and National Aged of Hanson Plc and from 2002-2004 Care Coordinator. Mr Anderson he was Chairman of Worley Group has a Bachelor of Economics from Limited. He was the President of the Sydney University and a Masters of Business Council of Australia from Management from MGSM. 2001-2004. From 1993-2000 he held the position of Managing Director and CEO of Pioneer International Limited, and from 1987-1993 he was Chairman and Managing Director of ESSO Australia Ltd. Dr Schubert is also a member of the Garvan Geoff Dixon Research Foundation Board. Nominated by the Garvan Research Foundation Mr Geoff Dixon is Chairman of the Australian Government’s major Patricia O’Rourke tourism marketing organisation Nominated by the Sisters of Charity Tourism Australia, and of the Professor Patricia O’Rourke is the Garvan Research Foundation. He Divisional Chief Executive Officer sits on the boards of publicly listed of St Vincent’s Health Australia’s Australian companies Crown Limited Garvan Institute of Medical Research · Foundation Annual Report 2014 Board Members Public Hospitals Division. Prior to this, and Adslot Ltd. Mr Dixon is also Professor O’Rourke was the CEO of on the board of the Museum of St Vincent’s Hospital Melbourne. She Contemporary Art Australia, the Jonathan Anderson Local Organising Committee of Nominated by the Sisters of Charity has more than 25 years’ experience in the health care industry, including the AFC Asia Cup 2015, and is the Mr Jonathan Anderson was the nursing and senior management Australian Indigenous Education St Vincent’s Health Network Chief Foundation Ambassador. Mr Dixon
GARVAN 35 was Managing Director and CEO of and the University of Sydney’s she has been Director of Strategy Qantas Airways Limited from 2001- School of Medicine. Professor for Westpac Banking Corporation; a 2008. He joined Qantas in 1994 Horvath is an honorary professor partner at McKinsey and Company, GARVAN.ORG.AU and was also the Chief Commercial of medicine at the University of specialising in the resources and Officer and, for two years, Deputy Sydney and chairs the Prosthesis financial services sectors; and Chief Executive. He has also Listing Advisory Committee of the Professor in Management and worked in the media, mining and Australian Government. He is also an Director of the MBA Program at government sectors. independent non-executive director the Australian Graduate School of of Crown Resorts Foundation, Management, University of New Crown Ltd and Crown Melbourne South Wales. She was made an Ltd. Professor Horvath is a fellow Officer of the Order of Australia of the Royal Australasian College in 2004 for her services to the of Physicians and is a distinguished performing arts, to business and practitioner, researcher and teacher. the financial services industry, His previous roles include being a particularly in the area of corporate director of Health Workforce Australia governance, and to the community. until 2014, a member of the NHMRC In 2001, she was awarded a Council and he was Chairman of the Centenary Medal for her service to Healthcare Committee until mid-2012. Australian society in business and Annette Cunliffe RSC He was previously a clinical professor the arts. Nominated by the Sisters of Charity of medicine at University of Sydney, a specialist renal physician at Royal Sister Annette attended St Vincent’s Prince Alfred Hospital (RPA), and the College Potts Point before becoming Area Director of Renal Services for a Sister of Charity. She completed a the RPA and Concord Repatriation BSc (UNSW), Diploma of Education General hospitals. He is also known (UNE), Master of Education as a leader in a range of medical (Hons) (UNSW) and PhD (Griffith), training and workforce organisations. meanwhile teaching in secondary He is also a former president of the colleges in various states, then Australian Medical Council and the holding the position of senior lecturer NSW Medical Board. at the Australian Catholic University. From 1996-2002 and since 2008 Annette Pantle Nominated by the Sisters of Charity Sister Annette has been Leader of the Sisters of Charity of Australia. Dr Annette Pantle completed her She has held the positions of medical degree at the University of President of Conference of Leaders Sydney before pursuing a career of Religious Institutes (CLRI; in rural general practice and then NSW) and the Inaugural Chair of metropolitan medical administration. the Stewardship Board of Catholic Dr Pantle holds a Masters of Public Health Australia and served on a Health, Fellowship of the Royal number of incorporated boards. She Australasian College of Medical is currently President of Catholic Administrators, Fellowship of the Religious Australia. Helen Nugent AO Australian Institute of Company Nominated by the NSW Minister Directors and Fellowship of the for Health Australasian Association for Quality Dr Helen Nugent is a non-executive in Health Care. Dr Pantle was the director. She is currently Chairman Clinical Governance Group General of Veda Group and Funds SA, the Manager and Chief Medical Officer $25 billion investment fund of the for St Vincent’s Health Australia South Australian Government as (SVHA) from 2010-2014. Prior to well as a non-executive director this position she was the Clinical of Origin Energy. Previously, she Practice Improvement Director has been Chairman of Swiss Re for the NSW Clinical Excellence (Australia); Swiss Re (Life and Commission – a statutory health John Horvath AO Health) Australia; and Sydney corporation with responsibility for Nominated by the Federal Minister Airport, and a non-executive director building capacity for quality and for Health of Macquarie Group; Mercantile safety improvement and reporting Mutual; and the State Bank of Professor John Horvath was the to the NSW Minister for Health. Garvan Institute of Medical Research · Foundation Annual Report 2014 Board Members New South Wales. Currently, in Australian Government Chief the not-for-profit sector, she is also Medical Officer from 2003-2009. Chancellor of Bond University; He currently has advisory roles President of Cranbrook School; and to the CEO of the NHMRC, the Chairman of the National Portrait Department of Health and Ageing Gallery of Australia. As an executive,
36 the Australia subsidiary for three years before moving to the US as the Development Group Vice President GARVAN.ORG.AU then returning to run the Asia-Pacific region for Microsoft. Mr Petre has served on many corporate and not- for-profit boards and currently serves on the Sydney Theatre Company Board and the advisory boards for the UNSW Australia Business School and the University of Sydney Medical Warren Scott Peter Smith School. Mr Petre is also an adjunct Treasurer, Nominated by the NSW Minister Nominated by UNSW Australia for Health professor at the Business School of the University of Sydney and the Professor Peter Smith is Dean of Mr Warren Scott is the Australian Business School of UNSW Australia. Medicine at the UNSW Australia Prudential Regulation Authority and President, Medical Deans ANZ. General Counsel and the former He specialised in cancer medicine Managing Director and the General and research following study in Counsel of Citigroup in Australia. Australia, USA and Germany. Prior to that he was a partner in Professor Smith has held senior an international law firm. He was hospital management posts in formerly the Chairman of the Brisbane and Melbourne and Woolcock Institute of Medical senior academic appointments at Research, as well as a delegate to the universities of Queensland, the Australian American Leadership Melbourne and Auckland. Dialogue. He is a member of the Law He is currently a board director Society of New South Wales, the Jillian Segal AM of St Vincent’s Health Australia, American Bar Association, the New Nominated by UNSW Australia Neuroscience Research Australia, York Bar Association, the Australian Ingham Medical Research Institute Ms Jillian Segal is a director of the Law Council, and the California Bar and the Sax Institute for National Australia Bank and ASX Association. Mr Scott is admitted as a Health Research. solicitor in New South Wales and as a Limited. She is also UNSW Australia lawyer in New York and California. Deputy Chancellor and is involved with a number of other community not-for-profit organisations, including as Chairman of the General Sir John Monash Foundation. Ms Segal is a trustee of the Sydney Opera House Trust and a member of the Australian War Memorial Council. Ms Segal is a former member of the Federal Government’s Remuneration Tribunal and has had a career in law, Lisa McIntyre regulation, governance and policy Nominated by the Federal Minister development. Formerly, she was Daniel Petre AO for Health Nominated by the Trustees of President of the Administrative Dr Lisa McIntyre is a non-executive St Vincent’s Hospital Review Council and Chair of the Banking and Financial Services director of the HCF Group and the Mr Daniel Petre has been at the Ombudsman Board. From 1997-2002, Cover-More Group, and Chair of Silex forefront of the technology industry Ms Segal was a commissioner of the Group Ltd, the HCF Foundation and in Australia for more than 25 years. Australian Securities and Investments Tutoring Australasia. Dr McIntyre Currently he is a founding partner Commission (ASIC), being the Deputy was formerly a senior partner with at AirTree Ventures (a technology- Chair from 2000-2002. Prior to joining LEK Consulting in Boston and focused venture capital company). ASIC, Ms Segal was a corporate Sydney where she led the firm’s Asia Prior to Airtree Ventures he was the lawyer specialising in corporate and Pacific Life Science and Health Care Founding Chairman of netus environmental law, having been a practice. She has spent the majority (a technology investment company partner at Allen Allen and Hemsley of her career as a strategy consultant acquired by Fairfax Media in 2013) (now Allens Linklaters). advising companies and organisations and prior to this role, he founded in the health and life sciences
Australia’s largest internet investment sector on growth strategies and Garvan Institute of Medical Research · Foundation Annual Report 2014 Board Members company, ecorp, (a subsidiary of performance improvement, and more Publishing and Broadcasting Limited). recently as a director and chair of Mr Petre spent nine years with organisations in health and technology Microsoft where he held a range of and services sectors. roles both in Australia and the US. He was the Managing Director of
GARVAN 37 GARVAN.ORG.AU
John Mattick AO FAA Bernadette Tobin Greg Paramor AO Nominated by the Garvan Board Nominated by the Trustees of Nominated by the Garvan of Directors St Vincent’s Hospital Research Foundation Professor John Mattick is the Dr Bernadette Tobin is the Director Mr Greg Paramor is the Managing Executive Director of the Garvan of the Plunkett Centre for Ethics at Director of Folkestone Limited, Institute of Medical Research, and St Vincent’s Hospital, Sydney, and a specialist property funds a conjoint Professor at St Vincent’s Reader in Philosophy at the Australian management group. Mr Paramor has Hospital Clinical School, UNSW Catholic University. Dr Tobin is been involved in the real estate and Australia. Most recently he was Honorary Ethicist at the Children’s funds management industry for more the Professor of Molecular Biology Hospital at Westmead, an honorary than 35 years. He is a past president and NHMRC Australia Fellow at the Associate Professor in the Faculty of of the Property Council of Australia Institute for Molecular Bioscience, Medicine at the University of Sydney, and past president of Investment University of Queensland. He was and a conjoint Associate Professor in Funds Association. educated at the University of Sydney the School of Medicine at the UNSW Mr Paramor is a director of a number and Monash University, where he Australia. She served for three triennia of not-for-profit organisations and obtained his PhD. He subsequently on the Australian Health Ethics is the immediate past Chair of the worked at Baylor College of Medicine Committee, a principal committee National Breast Cancer Foundation. in Houston and the CSIRO Division of of the NHMRC. She also chaired the Mr Paramor is also a board member Molecular Biology in Sydney. drafting group which prepared the of the Sydney Swans and Chairman He also spent research periods at the first Code of Ethics for Catholic Health of LJ Hooker Ltd. universities of Cambridge, Oxford, and Aged Care Services in Australia. Cologne and Strasbourg. He was Foundation Director of the Australian Genome Research Facility and the Institute for Molecular Bioscience. His honours include Fellowship of the Australian Academy of Science, Honorary Fellowship of the Royal College of Pathologists of Australasia and Membership of the European Molecular Biology Organisation. He received the inaugural Gutenberg Anthony Schembri Professorship at the University of Anne Keating Nominated by the Sisters of Charity Strasbourg, the 2011 International Nominated by the NSW Minister Professor Anthony Schembri joined the Union of Biochemistry and Molecular for Health St Vincent’s Heath Network as CEO in Biology Medal, the 2012 Human Ms Anne Keating is a company 2014. He brings with him 22 years of Genome Organisation Chen Medal director and holds board directorships experience in health including holding for Distinguished Achievement in of companies in a range of industries general manager positions at Liverpool Genetic and Genomic Research, and including financial services, property Hospital, Bankstown and Fairfield most recently the University of Texas and life sciences. She is on the boards Hospitals and clinical roles in both MD Anderson Cancer Center Bertner of the Goodman Group Ltd, REVA the hospital and community health Memorial Award for Distinguished Medical Inc and GI Dynamics Inc services. Professor Schembri currently Contributions to Cancer Research. and she is a governor of the Cerebral holds an academic appointment with Professor Mattick was appointed Palsy Foundation. Her former board the St Vincent’s Clinical School of an Officer in the Order of Australia memberships include Insurance the University of New South Wales in 2001 and awarded the Centenary Australia Group Limited, Ardent and is a director of the St Vincent’s Medal of the Australian Government Leisure Ltd, NRMA Limited, STW Curran Foundation, the Co-Chair of the
Garvan Institute of Medical Research · Foundation Annual Report 2014 Board Members in 2003. Communications Group, ClearView Steering Committee for the Nursing Wealth Limited, the WorkCover Research Institute of the Australian Authority of NSW and the Tourism Catholic University/St Vincent’s, Task Force. She was a trustee of the a trustee of the Peter Duncan Centennial Parklands and Moore Park Neurosciences Unit and a member Trust and was an inaugural director of the NSW Government Kids and at the Victor Chang Cardiac Research Families Council. Professor Schembri is Institute. Ms Keating was the General a surveyor for the Australian Council of Manager, Australia for United Airlines Healthcare Standards. 38 from 1993-2001. GARVAN.ORG.AU Garvan Research Foundation BOARD OF DIRECTORS
corporate boards and companies of all and charitable causes also reaches sizes. She has published many articles back many years, and in 1984 he and is often is asked to speak on was made a Member of the Knightly CEO succession and diversity at the Order of Vitez. Mr Farago joined the executive and board level. Ms Allen Foundation Board in 2008. leads a number of global strategy initiatives roles for one of the firm’s core client practices. She has been the Managing Partner of the Sydney office and co-leader of the Australian practice as well as Head of the Geoff Dixon Chair Consumer Products Practice Group Mr Geoff Dixon is the Chairman of for Asia Pacific. She is a member of the Australian Government’s major Chief Executive Women, a network of tourism marketing organisation Australia’s top women leaders. Prior Tourism Australia, and of the Garvan to joining EZI she worked at Procter Research Foundation. He sits on the and Gamble in the US and Australia. Melinda Conrad boards of publicly listed Australian Ms Allen has an MBA from Harvard Ms Melinda Conrad is a professional companies Crown Limited and Adslot Business School and a Bachelor of company director with governance Ltd. Mr Dixon is also on the board Arts from Smith College. Ms Allen and executive experience spanning of the Museum of Contemporary joined the Foundation Board in 2007. a range of industries including Art Australia, the Local Organising retail, media, financial services, Committee of the AFC Asia Cup consumer goods, healthcare, and 2015, and is the Australian Indigenous government. She is currently a Education Foundation Ambassador. non-executive director of OzForex Mr Dixon was the Managing Director Limited, The Reject Shop Limited, and Chief Executive Officer of Qantas and the Australian Brandenburg Airways Limited from 2001-2008. He Orchestra. She is a member of the joined Qantas in 1994 and was also Minter Ellison Advisory Board and Chief Commercial Officer and, for two the Australian Institute of Company years, Deputy Chief Executive. Directors Corporate Governance He has also worked in the media, Committee. Ms Conrad has also mining and government sectors. Gabriel Farago served as non-executive director of Mr Dixon joined the Foundation Board Mr Gabriel Farago practised as a David Jones Limited, APN News as Chairman in 2009. solicitor and barrister for over 30 and Media Limited, NSW Clinical years, specialising in commercial Excellence Commission, and NSW disputes both in Australia and Agency for Clinical Innovation. She overseas, before becoming a full- has previously held executive roles time writer. He is now a published at Harvard Business School, Colgate- author of international thrillers and Palmolive, several retail businesses as short stories. His novels – The founder and CEO, and in strategy and Empress Holds the Key, and The marketing advisory. Ms Conrad holds Disappearance of Anna Popov – a BA (hons) from Wellesley College were released in 2013, and 2014 in Boston, an MBA from Harvard respectively, together with Letters Business School, and is a Fellow of from the Attic, a collection of short the Australian Institute of Company Jane Allen stories. Mr Farago speaks several Directors. Ms Conrad joined the Ms Jane Allen is a senior partner in languages, holds degrees in literature Foundation Board in September 2003. Garvan Institute of Medical Research · Foundation Annual Report 2014 Board Members Egon Zehnder’s (EZI) Sydney office, and law, and takes research very where she focuses on chief executive seriously. Deeply interested in officer and board appointments, as history and archaeology, he spends well as governance matters. Ms several months a year overseas Allen has been at EZI for more than researching and promoting his 15 years and has consulted with books. A passion for philanthropic
GARVAN 39 in Houston and the CSIRO Division of Molecular Biology in Sydney. He also spent research periods at the universities of Cambridge, Oxford,
GARVAN.ORG.AU Cologne and Strasbourg. He was Foundation Director of the Australian Genome Research Facility and the Institute for Molecular Bioscience. His honours include Fellowship of the Australian Academy of Science, Honorary Fellowship of the Royal Bruce Baird AM John Schubert AO College of Pathologists of Australasia The Hon Bruce Baird has an and Membership of the European Dr John Schubert was appointed to impressive career spanning the Molecular Biology Organisation. the Garvan Institute Board in April Australian Trade Commission and He received the inaugural Gutenberg 2013 and appointed Chairman in May the parliaments of NSW and the Professorship at the University of 2013. He is currently a director of BHP Commonwealth. Until recently Mr Strasbourg, the 2011 International Billiton Limited, BHP Billiton Plc and Baird served on several national Union of Biochemistry and Molecular the Chairman of the Great Barrier Reef boards including as Chair of Biology Medal, the 2012 Human Foundation. Until April 2013 he was the Tourism and Transport Forum and Genome Organisation Chen Medal Chairman of the biotech start-up G2 the Commonwealth’s Refugee for Distinguished Achievement in Therapies Ltd and from 2004-2010 he Resettlement Advisory Council. Genetic and Genomic Research, and was Chairman of the Commonwealth Among his positions with the NSW most recently the University of Texas Bank of Australia, Deputy Managing Parliament, he was a member of the MD Anderson Cancer Center Bertner Director from 2000-2004 and a director NSW Legislative Assembly from 1984- Memorial Award for Distinguished from 1991-2000. He was the President 1995, serving as Shadow Minister Contributions to Cancer Research. of the Business Council of Australia for Finance, then for Transport and Professor Mattick was appointed an from 2001-2004. From 2000-2003 he Aboriginal Affairs, as Minister for Officer in the Order of Australia in 2001 was a director of Hanson Plc and from Transport and Regional Services, and awarded the Centenary Medal of 2002-2004 he was Chairman of Worley Minister for Sydney’s Olympic Bid, and the Australian Government in 2003. Group Limited. From 1993-2000 he Minister for Tourism and Roads. Professor Mattick joined the Foundation held the position of Managing Director He was the Liberal Party in NSW Board in 2012. and CEO of Pioneer International Deputy Leader from 1992-1995. From Limited and from 1987-1993 he was 1995 he served as the Managing Chairman and Managing Director of Director of the Tourism Council ESSO Australia Ltd. Dr Schubert joined Australia and as Chair of National Rail the Foundation Board in 2013. Corporation and a director of ABN AMRO Hoare Govett, Tourism Training Australia and Tourism Education Services. He served in Federal Parliament, House of Representatives, from October 1998 until his retirement at the 2007 election. Mr Baird joined the Foundation Board in 2010. Simon Mordant AM Mr Simon Mordant AM is Executive Co-Chairman of Luminis Partners, a leading independent corporate Clare Nolan RSC advisory firm advising major corporates on their merger and acquisition and Sister Clare Nolan was elected The capital markets strategies. Previously Congregational Leader of the Sisters he was the Vice Chairman and of Charity in 2014. Sister Clare entered Managing Director of Greenhill and the Sisters of Charity following Co Inc. He is a chartered accountant nurse training at the Mater Hospital and is Chair of the Museum of in Brisbane. She has over 43 years Contemporary Art Australia, a board experience in health and research John Mattick AO FAA member of the Australian Broadcasting services. Her ministry experience Professor John Mattick is the Executive Corporation, MOMA PS1 in New includes health, welfare, governance Director of the Garvan Institute of York, Wharton Executive Board in and administration, serving on boards Medical Research, and a conjoint Asia and Commissioner for Australia within the Sisters of Charity Health
Garvan Institute of Medical Research · Foundation Annual Report 2014 Board Members Professor at St Vincent’s Hospital Clinical at the 2015 Venice Biennale. He is a Service and other Church bodies. Her School, UNSW Australia. Most recently member of the Executive Committee present ministry is one of hospitality. he was the Professor of Molecular of the International Council of the Tate, Hospitality to women who have loved Biology and NHMRC Australia Fellow at the Leadership Council of the New ones in hospital within the St Vincent’s the Institute for Molecular Bioscience, Museum, the International Council campus, to patients who come from University of Queensland. He was of the Museum of Modern Art and the Solomon Islands for health care educated at the University of Sydney advisory board member of Venetian within the St Vincent’s campus, to and Monash University, where he Heritage. Mr Mordant joined the women and men who suffer with obtained his PhD. He subsequently Foundation Board in 2009. mental health issues. Sister Clare joined 40 worked at Baylor College of Medicine the Foundation Board in 2010. GARVAN.ORG.AU
Jeanne-Claude Strong John Landerer CBE AM Wal King AO Dr Jeanne-Claude Strong is a qualified Mr John Landerer is a solicitor Mr Wal King has worked in the medical practitioner with a post- specialising in corporate advisory work construction industry for over 40 graduate diploma in applied finance and is also a professional company years and was the Chief Executive and investment and a Bachelor of Arts director. He is currently Chair of Officer of Leighton Holdings Limited, in Literature and Philosophy. Dr Strong Goldsearch Limited and other private a company with substantial operations established and ran three medical clinics companies. He has served as the Chair in Australia, Asia and the Middle East, in Melbourne and Sydney, focusing on of the Home Purchase Assistance from 1987 until his retirement on 31 occupational, sports and preventative Authority and is on the board of Life December 2010. Mr King is Chairman medicine and stressing the importance Education Australia and the Royal of Sundance Resources Limited and of lifestyle management. She was Institute for Deaf and Blind Children Asia Resource Minerals plc, is Deputy a member of the Advisory Board of as well as on the boards of various Chairman of the UNSW Foundation Bluearth for 10 years, a not-for-profit charitable institutions. Mr Landerer Limited and was Deputy Chairman organisation, which promotes greater holds an honorary doctorate from of Ausdrill Limited until 28 October physical activity to reduce the incidence Macquarie University in business and 2014, a director of Coca-Cola Amatil of disease and increase well-being. commercial law. He is also a Fellow of Limited and Kimberley Foundation She is a pilot with a command multi- University of Sydney. Mr Landerer is a Australia Limited, and a senior adviser engine instrument rating and has Member of the Order of Australia and of CITIC Pacific Limited. Mr King is an flown her own plane from California a Commander of the Most Excellent honorary fellow of the Institution of to Australia. Dr Strong has a passion Order of the British Empire. He is also Engineers Australia, a foundation fellow for yacht racing with an occasional a Commander in the Order of the of the Australian Institute of Company foray in international regattas, as well Star of Italian Solidarity. He joined the Directors, and a fellow of the Australian as mountain climbing (the highest Foundation Board in 2007. Institute of Management, the Australian mountain in Antarctica, Mt Vinson Institute of Building and the Australian 16,066 feet and the highest mountain Academy of Technological Sciences in Oceania, Puncak Jaya at 16,535 and Engineering. Mr King joined the feet), motorcycle riding, and scuba Foundation Board in 2010. diving. Dr Strong joined the Foundation Board in 2011.
Brad Rees Mr Brad Rees is involved in a number of charitable, arts and educational interests and is a director of a private investment Loftus Harris AM company. He was previously a managing director and equity partner of Mr Loftus Harris is a professional Lyn Gearing the investment banking firm Goldman non-executive director and an advisor Ms Gearing was appointed to the Sachs JBWere. Mr Rees was with the to industry and government. He has Garvan Foundation Board as a firm for 23 years and worked in the been chair and member of numerous representative of the Sisters of Charity. Melbourne, Sydney and London offices national, state and industry bodies Ms Gearing is currently a director providing financial and investment concerned with issues of economic of Commonwealth Superannuation banking advice to corporations and development, international trade and Corporation. Ms Gearing has experience governments in Australia and overseas. investment, infrastructure, innovation in superannuation, funds management, Mr Rees is Chairman of G2 Therapies and technology. He previously held
corporate finance and management Pty Ltd and joined the Foundation Board chief executive officer and senior Garvan Institute of Medical Research · Foundation Annual Report 2014 Board Members consulting. Ms Gearing joined the in 2008. executive positions in the NSW, Foundation Board in 2005. Queensland and Commonwealth public sectors. He also served extensively overseas as an Australian Trade Commissioner. Mr Harris joined the Foundation Board in 2008.
GARVAN 41 GARVAN.ORG.AU LEADERS IN SCIENCE SEMINARS
Garvan’s Leaders in Science seminars are held each Monday in the auditorium and are attended by staff and students from Garvan and the wider St Vincent’s Hospital research APRIL JUNE precinct. The seminars Professor Hung Nguyen Director, Centre for Professor David Health Technologies, University of Technology, Sydney Thorburn Director, Genetics feature renowned “A less traumatic approach: non-invasive Theme, Murdoch Children’s national and international medical devices.” Research Institute, Melbourne “Massively parallel specialists from a variety Professor Eric Miska Herchel Smith Chair of sequencing identifies Molecular Genetics,The Gurdon Institute, University new genes and of organisations. of Cambridge The seminars aim to “Transgenerational epigenetic memories.” new mechanisms in mitochondrial engage, educate and OXPHOS diseases.” inspire our researchers. Dr Paul Baldock Head, THROUGHOUT 2014, Bone Metabolism Group, Bone Biology Division, SPEAKERS INCLUDED: Garvan Institute “Why bone is more than just a stick to hold you up.”
Dr Alyson Ashe School MARCH MAY of Molecular Bioscience, University of Sydney Professor Josef Penninger Professor Simon Easteal John Curtin School of “Transgenerational Scientific Director of IMBA Institute of Medical Research memory in C. elegans.” Molecular Biotechnology, Vienna “The National Centre for Indigenous Genomics “From model organisms to (NCIG): Research engagement with the new medicines.” first Australians.”
Garvan Institute of Medical Research · Foundation Annual Report 2014 Leaders in Science Seminars Professor Stephen Simpson Associate Professor Shane Grey Head, Director, Charles Perkins Centre, Transplantation Immunology Group, Garvan Institute University of Sydney “Tissue factors drive inflammation and “Getting the balance right: the inflammatory disease.” geometry of longevity and metabolic health.”
42 JULY Professor Kathryn North GARVAN.ORG.AU Director, Murdoch Children’s Research Institute, Melbourne “The genomics revolution – SEPTEMBER a personal, national and global Professor Geoff Lindeman Joint Professor Jozef Gecz perspective.” Division Head, Stem Cells and Cancer, Professor of Human Genetics, Adelaide Walter and Eliza Hall Institute of Medical Women and Children’s Hospital and Professor Ralph Kuppers Institute Research, Melbourne University of Adelaide of Cell Biology (Cancer Research), “Exploring the mammary epithelial “Making sense of DNA variation, Faculty of Medicine, University of hierarchy and patient-derived genetics and neurobiology of Duisburg-Essen xenograft tumour models to get epilepsy, intellectual disability and “Generation and function of human abreast of breast cancer.” cerebral palsy.” memory B cells.” Professor Bobby Gaspar Professor Professor Frank Gannon Professor Anthony Hannan of Paediatrics and Immunology, Institute Director, QIMR Berghofer Medical Florey Institute of Neuroscience and of Child Health, London, UK Research Institute Mental Health, University of Melbourne, “Genetic basis of SCID, newborn “The estrogen receptor and me.” Melbourne Brain Centre screening and correction by “Gene environment interactions gene therapy.” mediating experience-dependent plasticity in the healthy and Professor Peter Leedman Director, diseased brain.” Harry Perkins Institute of Medical Research, University of Western Australia “MicroRNAs, replacement therapy and cancer – how far have we come?”
OCTOBER Professor Belinda Parker School of Molecular Sciences, La Trobe University “Using immunocompetent models to uncover metastasis biomarkers and therapeutic targets.” DECEMBER Professor Peter Klinken Professor Maria Kavallaris AUGUST Chief Scientist of WA, Harry Perkins Head of the Tumour Biology and Institute of Medical Research, Targeting Program, Children’s Cancer Associate Professor Clare Scott University of Western Australia Institute of Australia, Sydney Head, Stem Cells and Cancer Lab, “A model for red blood cell “Microtubules: tumorigenesis, Walter and Eliza Hall Institute of production and lineage switching.” metastasis and therapeutics.” Medical Research, Melbourne “Using patient-derived xenografts to improve drug targeting in high grade serous ovarian cancer.” NOVEMBER Professor Andreas Strasser Joint Division Head, Molecular Genetics of Professor Brandon Wainwright Professor Francisco (Paco) X Real Cancer, Walter and Eliza Hall Institute Director, Institute for Molecular Head, Epithelial Carcinogenesis Group, of Medical Research, Melbourne Bioscience, University of Queensland Spanish National Cancer Research “How does p53 actually protect us “Hedgehog signalling controlling stem Centre, Madrid from developing cancer?” cells and common human cancer.” “Bladder cancer and NGS: from plenty of challenges to plenty Professor Kum Kum Khanna Dr Timothy Bredy of opportunities.” Leader, Signal Transduction Lab, Cognitive Neuroepigenetics, Queensland QIMR Berghofer Medical Research Brain Institute, University of Queensland Professor Andrew Brown Institute, Brisbane “DNA modifications and Head of School of Biotechnology and “DNA damage repair from genome adaptive behaviour.” Biomolecular Sciences, UNSW Australia
maintenance to therapeutic targets.” “Shaggy tales of cholesterol Garvan Institute of Medical Research · Foundation Annual Report 2014 Leaders in Science Seminars Professor Mark Febbraio metabolism.” Associate Stuart Tangye Head, Head, Cellular and Molecular Immunology and Immunodeficiency Lab, Metabolism Lab, Baker IDI Heart and Immunology Division Garvan Institute Diabetes Institute, Melbourne “Molecular regulation of human “Heat shock protein 72: A panacea immune responses.” for disease prevention?”
GARVANGARVAN 43 GARVAN.ORG.AU GARVAN COMMUNITY A big thank you to all of those who have supported Garvan throughout 2014
LIFE GOVERNORS The Bill and Patricia Ritchie Ms Jill Coggan Ms Heather P Hindle Ms Tanya Roddan Foundation Dr & Mrs Roger and Mr Lionel Hirning Mr & Mrs Christopher and Allind Pty Ltd Mrs Margaret Rose AM Carole Cole Mr Hilton Hollingdale Nancye Rolfe Amadeus Energy Limited The Ross Trust Mrs Robyn Collings Mr Byram Johnston OAM Mr Bruce Rosenberg Mr John Armati Roth Charitable Foundation Mrs Sandra Constantine and Mrs Deborah Johnston Elizabeth Rudduck ASX Group Scrimshaw Foundation Mrs Philippa Croker Mrs Florence Jones Mr & Mrs Ken and ASX Thomson Reuters Mr & Mrs Tim and Mrs Martha Danas Mrs Isabel (Rae) Kennedy Judy Sargeant Charity Foundation Sally Sims Mr Rodney F Darke Ms Wendy Keys Ms Coral Saunders Australian Cancer Research Mr Robert Strauss MBE Mrs Betty Saxby Foundation Mr Kenneth Davies Mr & Mrs Jeffry and Mr Laurie Sutton Lyn Kirby Mrs Wilhelmina H. Mr Charles P Curran AC Mrs Eileen De Lapp Suttons Motors Ms Lili Koch Schippers St Vincent’s Curran Mrs Luise de Longueville Management Dr John Schubert AO and Foundation Mrs Denise Debeck Ms Josie La Spina Dr John Tonkin Mrs Prue Schubert Mr & Mrs Geoff and Mr Christopher Ladd Mr Tom Devitt Miss Thelma Shepherd Dawn Dixon Westfield Holdings Ltd Ms Gabriella Lang Mrs Marlene Dixon Mrs Hilma Simon Mr & Mrs Peter and E J Whitten Foundation Mr Peter Dixon Mr Barry Thompson and Ms Val Duncan Witchery Roberta Lauchlan Mrs J Sindel-Hand Mr John Dobies The Late Mr Alan Elder Ms Elizabeth Lee Kathryn Ann Smith Mr John Dowd Lady (Mary) Fairfax AC OBE Mrs Shirley Lindoy JP Miss Angela Sofoulis PARTNERS FOR THE Mrs Valda Eastment Ferris Family Foundation Ms Maria Lydaki Ms Betty Song FUTURE Miss M M Evans Mr Laurence S Freedman Mrs Gwenda Macdonald Mrs Cynthia Southwell AM Mrs Margaret Adams The Evans Family Ms Moyra Maestros Mrs Liese-Lore Spring Elizabeth Fyffe Ms Ronelle Adams Mrs Wai Chiew Fairley Dr Norman Marshall Ms Maureen A Stephenson Mr James Patrick Garvan Ms Wilhelmina Antoniesen Ms Daile Falconer Mrs Doreen NE Martin Mr Rick Stevens and Family Mr Ian A N Armstrong Mr & Mrs Gabriel and Mr Lance Matheson Dr Jeanne-Claude Strong George Patterson Pty Ltd Mr Peter Askew Joan Farago Ms Nina Mavro Mr & Mrs Peter and Mrs Janice Gibson & Ernest Miss Margaret Atkinson Mrs Grace Faulks Diane Sturrock Heine Family Foundation Mr Desmond J McCarthy Dr W. 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44 GARVAN.ORG.AU
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In Memory of the Late Dr Colleen Kane Ms Maureen Macfarlan Mr & Mrs Wayne and Kathrin Nell A Wilshire Gretina Norton Mrs Gabrielle A Ryan Mr & Ms Keith and Macquarie Group Mrs Cheryl Sutherland Foundation NSW Ministry of Health Mrs Margaret Ryan Judith Kay Mr Jim Sweeny Mr & Mrs James and Mrs Margaret O’Brien Sachdev Foundation Mr & Mrs Patrick and Sydney Airport Ladies Janice Main Gordon and Christine Beryl Keane Mr Michael O’Dea KESG Association Mrs Daisy Mallett AM and Mrs Marianne Windeyer Mrs M Keighley Mr & Mrs Nickleby Tait O’Dea Mrs Barbara A Sanders Mrs Helen J Keir Mr & Mrs Roy and Cindy Manassen Mr John O’Farrell Mr Harry Tamvakeras
Garvan Institute of Medical Research · Foundation Annual Report 2014 Community Mr Stirling Sanderson Professor Geoffrey Ms Pamela Taylor Kellerman AO The Late Mr Robert Maple- Mr William Officer Sanitarium Health & Brown AO and Mrs Susan Ms Lysia O’Keefe Wellbeing Company Mrs Rosemary Taylor Mrs Caroline Kennedy Maple-Brown AM Dr Geoffrey S Oldfield Sanwa P/L Ms Victoria Taylor John & Connie Kennedy Mrs Sandra Marder Charitable Trust Mrs Lorna Oliff Mr D & Mrs A Saul Mr & Mrs J W & Mrs Dianne Martin M K Te Strake Mr Steve Kennedy The Rodney & Judith Say Family Foundation Mrs Doreen NE Martin O’Neil Foundation The Tea Centre Pty Ltd
46 Mr Damien Thompson Mr Robert Yeates Emirates Wolgan Valley Domino’s Pizza Enterprises Guillaume Brahimi Mrs Estelle Thurn Mr J M Yorke Emporium Hotels Group Limited Illumina Mrs Joy Timbrell Ersko Pty Ltd Freelake Pty Ltd Langham Hotels GARVAN.ORG.AU Ms Karen Tompkins Escarpment Group G & K Graham Lindt and Sprugli YOUNG GARVAN Tour de Cure Mrs Lisa Fleetwood Leeson’s Lindwall and Ward SUPPORTERS Mrs & Mr Julia & Simon FOX FM – Fifi and LV Forklifts Melinda Conrad Tregoning Hotel Sofitel Auckland Dave Breakfast Show Mr Peter Ranwick Viaduct Harbour Mira Moon & The Mira Charlie & Connie Trenchard Foxtel Management Weblease Hong Kong The Island Sydney Mr Walter Turnbull Pty Ltd Weinzier Naomi Hamilton Trivett Classic BMW Mr Warren Turner Gambaro Hotel Mr Tony Willacy Photography Quantum Charters Tusa Pty Ltd Gilgandra Financial Neil Perry AM NSW Waratahs Services Ltd Supporters Twin Towns Services Paspaley Community Foundation Tequila Tromba TAFE Queensland Gold Australian College of Perpetual Private Coast Massage Pty Ltd Limited Outrigger Little Hastings Prime Audio Visual Mr Peter Unwin Street Resort and Spa Mr & Mrs Wade and Bella Bleu Anna Hannasky Qantas Airways Upper Murray Horseman’s Sofitel Queenstown Hotel Bendigo and Adelaide Bank & Spa Mr Joshua Hodgkinson LtdBloome Enterprises Pty Rockpool Bar and Association Grill, Sydney Robert Oatley Vineyards Ms S Hurley Ltd trading as The Village Mr Ian Vale Agency Roses Only Pty Ltd In Design Australia Mrs Maya Van Rol Cleverbits Saffire Freycinet Crowne Plaza Hunter Intermedia Mr Robert Varga Valley Coles Supermarkets Samuel Smith and Son Jayco Kay Vernon Lilianfels Blue Mountains Australia Pty Ltd Serge Danserau Mr Andrew Johnson- Vodafone Foundation Resort and Spa Countrywide Embroidery Sofitel Wentworth Sydney Australia AJPS PTY LTD Pty Ltd WorldMark South Sydney Swans Wade Civil Engineering Pacific Resort R T Gaven Creative Legal Pty Ltd Ladies in Pink The Australian Craggy Range Deventer Public Relations Brandenburg Orchestra Mr & Mrs John and Emporium Hotel Brisbane Marriott Hotel Eureka Operations Pty Ltd Megan Wade The Sydney Theatre The Rosebay Hotel Miss Roberta Mascitti trading as Coles Express Company Mr Peter Wade 3 Minute Angels McLeod Family Foundation Final Sound Mrs Caroline Walder Mobile Laser Combat Pty Garmin Australasia Pty Ltd Charles Heidsieck BEQUESTS - Mr James Waley Ltd t/a Tas Laser Skirmish iSentia Bold Food Catering ESTATE OF The Walker Family Money Now Pty Ltd Jayco Corporation Pty Ltd Foundation’ Chase Gallery THE LATE Mornington Secondary Kaos Custom Bikes Mr Ian Wall College Sponsors Late Night Films Waybrett James Avery Mr Barry Walsh NRMA Gold sponsor - NAK Peter E Clarke Mr & Mrs J B Walsh Park Hyatt Sydney State Custodians Nobel Beverages Pty Ltd William, Edward and Mr Tim Wang Ms Julie Pearman Silver sponsor - trading as Pureau Water Ellen Dixon Dr J R Warneford Accor Hotels Capital Chemist ACT Oakley South Pacific Pty Ltd Claire Fischer & NSW Mrs Susan Watson Park Tool Harold Callaghan Garvan Goods in Kind Pink Butterfly Charity Mr Neville Webb Neville Goode (Cathy, Georgia, Karen, Pivotel Satellite Pty Ltd Frank Digital Wayne P & Lesley Mimma, Sandra) Print Design Australia John Grant M Webster Intermedia Ms Lyn Rogers Pty Ltd Margaret Ferris Kirkpatrick Ms Alexandra Wedutenko Moreton Hire Mr Les Silverman Ralf Bohle GmbH trading Marjorie G Lawn Mr Michael Weekes as Schwalbe Light House Print Group Mrs Lola Silverman Kevin P Maguire The WeirAnderson Uber Global Pty Ltd Sofitel Sydney Wentworth Wesselina Miller Foundation Vodafone Australia Ltd Mrs Alicia Staindl Iris Morgan Mr Howard Welsh LOVE YOUR Woodstock Studios Richard Padmore Westpac Banking SISTER Templestowe Park Corporation (WBC) Primary School Alan Patterson Donors Mrs Judith Wheeldon AM Terrigal High School GALA Elizabeth J Scully Mr Malcolm White Aardvark Adventures The York by Swiss-Belhotel SUPPORTERS Helen Edith Stockman Kim and Peter Whitfield Prof Judy Anderson TMF Group Tatiana Suslov Accor Mr Craig Whitworth Mr Ashley Baker Toga Hotels Joan H Thomas ANZ Stadium Mrs Lyn Williams AM Bendigo Bank Mrs Sarah Vollmerhause Harold Todhunter Art Series Hotel Group Dr & Ms Phillip and Ms Michelle Benfold Mr Jeff Wall Yvonne Pamela Tull Bernard McGrath Elizabeth Williams BHP Billiton Limited Ms Helen Ward Robert Watson Bold Food Willowie Nominees Pty Ltd Bite Size Coffee Treats William Creek Gymkhana June P Wesala Committee Bright Red Oranges Mr David Wilson Blue Mountains Vera Zukerman Camilla Mr Raymond Wilson International Hotel Wyndham Management School Carla Zampatti Mr Peter Winters Necia Zadow Broadband Solutions Mrs Karin Zeitsch Clearly Contacts Ms Susan Wishart Pty Ltd Cooley Auctions Mr Frank Wolff Cebas Pty Ltd trading Sponsors Daniel Cook – Butler Inc. Peter & Ann Wolstenholme as IKEA 7PM Company Pty Ltd David Jones Wood Family Foundation Coca-Cola Amatil Ark Construction Group Dinosaur Designs Garvan Institute of Medical Research · Foundation Annual Report 2014 Community Mr Brian F Wood Community Enterprise Pty Ltd Foundation Fresh Catering Mr & Mrs Jack and Automotion Leah Woolf Mr Andrew Cox Geoff and Dawn Dixon BC Com Pty Ltd Woolgoolga Lions Club Miss Emma Crethary Grandiflora BFN Development P/L Mrs Penelope Wright Daylesford Cinema Greg Paramor Cutting Force P/L Michael & Shirley Wrigley East Hotel Guillaume
GARVAN 47 GARVAN.ORG.AU PEER REVIEWED FUNDING Peer reviewed grants are those that have been selected for funding in a highly competitive process. A panel of expert scientists assess all grant applications and rank them on the scientific merit of the proposed research and track record of the applicants. Only a small proportion of grant applications are funded in each round, due to budget restrictions rather than the quality of the proposals. For example, in 2014 only 16 per cent of NHMRC Project Grant applications were funded across the nation, even though at least 50 per cent were considered worthy of being funded. Below is a list of the peer reviewed grants awarded to Garvan researchers and their collaborators in 2014.
FUNDING AMOUNT YEARS TYPE OF GRANT RESEARCH TEAM ORGANISATION AWARDED AWARDED
Dr Liz Caldon $360,000.00
A/Prof Marcel Dinger, Prof Sandra OToole (Royal Prince Alfred Hospital), Dr Ann McCormack, Dr Mark Cowley, A/Prof Richard Harvey (St $360,000.00 Vincent's Centre for Applied Medical Research), A/Prof Ruta Gupta (Royal Prince Alfred Hospital), Cancer Council NSW Project Dr Mark McCabe 2015-2017
Prof Neil Watkins, Dr Jason Cain (MIMR-PHI $360,000.00 Institute of Medical Research)
Prof Neil Watkins, Dr Vinod Ganju (Monash University), Dr Thomas John (Ludwig Institute $300,077.00 for Cancer Research), Dr Wendy Cooper
Prof Chris Ormandy, Prof Sue Clark, Prof Mike Rogers, Dr Alexander Swarbrick, Dr Paul 2014-2015 Cancer Institute NSW Project Timpson, Dr Marcel Batten, Dr David Gallego- $304,000.00 (1 year) Ortega, Dr Liz Caldon, Dr Winnie Tong (St Vincent's Centre for Applied Medical Research)
Colorectal Surgical Dr Penelope De Lacavalerie, A/Prof Maija 2015-2016 Society of Australia Grant-in-Aid Kohonen-Corish, A/Prof Matthew Morgan $90,000.00 (1 Year) and NZ (Sydney South West Area Health Service)
Cure Cancer Australia Foundation/Cancer Project Dr Phillippa Taberlay $199,298.00 2014-2016 Australia
Dr Mohammed Bensellam, A/Prof Ross Laybutt
Prof Greg Cooney, Dr Amanda Brandon, A/Prof Diabetes Australia Ross Laybutt Grant-in-Aid $60,000.00 2015 Research Trust Dr Paul Lee
Dr Carsten Schmitz-Peiffer, Dr Amanda Brandon Garvan Institute of Medical Research · Foundation Annual Report 2014 Peer Reviewed Funding 2014-2015 Grant-in-Aid A/Prof Antony Cooper, Dr Boris Guennewig $55,459.98 Michael J Fox (1 year) Foundation for Parkinson's Research Project Dr Bryce Vissel, Ms Sandy Stayte $367,088.62 2015-2016
Motor Neurone Disease Dr Graham (Greg) Neely, Dr. Thang Manh Research Institute of Grant-in-Aid $100,000.00 2015 Khuong Australia
48 FUNDING AMOUNT YEARS TYPE OF GRANT RESEARCH TEAM ORGANISATION AWARDED AWARDED GARVAN.ORG.AU Project Prof Trevor Biden, Prof Kazunori Imaizumi $603,813.00
2015-2017 Project - New Dr Tyani Chan $512,543.00 Investigator
Project Dr Elissa Deenick, Dr Cindy Ma $457,837.80
Project A/Prof Cecile King, Prof Jonathan Sprent $643,134.00
Project Dr Paul Lee $379,632.80
Project - New Dr Kim Loh $460,105.50 Investigator
Project Prof Susan Clark, Dr Clare Stirzaker $616,038.30
Dr Marina Pajic, Dr Paul Timpson, A/Prof Anthony Gill (Royal North Shore Hospital), Prof Project $614,495.00 Stephen Clarke (Kolling Institute of Medical Research), Dr Andrew Burgess 2015-2017
National Health and Prof David Thomas, Dr Arcadi Cipponi, Dr David Medical Research Project $668,813.00 Council Goode (Peter MacCallum Cancer Centre)
Dr Paul Timpson, Dr Jennifer Morton (The Beatson Institute, UK), A/Prof Yingxiao Wang Project $668,813.00 (University of California, San Diego), Dr Marina Pajic
Prof Neil Watkins, Prof Stephen Baylin (Johns Project Hopkins University), Dr Jason Cain (MIMR-PHI $516,772.00 Institute of Medical Research)
Project Dr Maya Kansara, Prof David Thomas $627,462.50
Project Prof Herbert Herzog $694,152.00
Project Dr Carsten Schmitz-Peiffer, Prof Trevor Biden $872,512.00 2015-2018 Prof Mike Rogers, A/Prof Jacqueline Center, Project Dr Tri Phan, Dr Andrew Jenner (University of $593,501.50 Wollongong), A/Prof Eva Segelov (UNSW)
Project Prof David Ryugo $881,355.00 2015-2019
National Institutes of 2014-2015 Grant-in-Aid Dr Daniel Hesselson, A/Prof Shane Grey $105,600.00 Health USA (1 year)
Parkinson's NSW Grant-in-Aid Dr Bryce Vissel, Ms Sandy Stayte $50,000.00 2014
Prof Peter Croucher, Mike Rogers, Alex Swarbrick, Vanessa Hayes, Tony Costello Prostate Cancer (University of Melbourne), Belinda Parker Program $3,000,000.00 2014-2017 Foundation of Australia (LaTrobe University), Himisha Beltran (Cornell University), Christina Jamieson (University of California, San Diego)
Establishment Garvan Institute of Medical Research · Foundation Annual Report 2014 Peer Reviewed Funding Ramaciotti Foundation Dr Paul Lee $75,000.00 2015 grant
St Vincent's Clinic Prof Neil Watkins, Dr Emily Stone (St Vincent's Grant-in-Aid $50,000.00 2015 Foundation Hospital)
Therapeutic Innovation 2014-2015 Project Prof John Mattick, A/Prof Marcel Dinger $189,000.00 Australia Ltd (TIA) (1 year)
GARVAN 49 GARVAN.ORG.AU FINANCIAL HIGHLIGHTS Statement of financial position as at 31 December 2014
PROFIT AND LOSS STATEMENT
2014 2013 2014 2013 REVENUE EXPENDITURE ($’000) ($’000) ($’000) ($’000)
Research income Employment expenses 43,220 40,249
NHMRC grants 15,393 20,473 Direct research costs 12,247 11,014
Other peer-reviewed grants 13,319 9,952 Depreciation and 11,282 10,627 amortisation Other grants 1,577 761 Administration 5,056 4,792 Commercial income 495 114 Fundraising* 2,149 1,728 Total research income 30,784 31,299 Building operations 4,868 4,731
Share of losses of Infrastructure support associates accounted for 43 41 using the equity method NHMRC IRIISS grant 2,897 3,827
Finance costs 1,096 1,348 UNSW support 615 2,158
Total expenditure 79,961 74,530 NSW government MRSP 9,105 4,034 support Net surplus (deficit) (4,717) 537
Total infrastructure support 12,617 10,019 * Fundraising costs exclude employment expenses.
The Institutes’s income remained much the same in 2014 as it was in 2013, in the face of systemic challenges being Donations and bequests 21,622 23,000 experienced by medical research institutes in Australia. The key drivers of the increased expenditure in 2014 were up-front costs incured in the development of Garvan’s genomics capability, underwriting in new researchers and increases in the costs of Other income The Kinghorn Cancer Centre, primarily related to depreciation and employment costs. The accounting deficit in 2014 includes a number of non-cash items. Cash and other financial assets Facility charges 7,053 4,949 increased after reducing debt by $2 million.
Investment/interest income 2,847 5,422
Net gain on disposal of property, plant and 266 0 equipment Garvan Institute of Medical Research · Foundation Annual Report 2014 Financial Highlights Net gain on interest swap derivative not qualifying as 53 377 hedges
Total other income 10,220 10,748
Total revenue 75,244 75,067
50 GARVAN.ORG.AU
BALANCE SHEET
2014 2013 2014 2013 ASSETS LIABILITIES ($’000) ($’000) ($’000) ($’000)
Current assets Current liabilities
Cash and cash equivalents 38,463 34,261 Trade and other payables 3,611 6,104
Trade and other receivables 5,231 5,576 Borrowings 3,366 394
Financial assets at fair value Provisions 4,365 4,206 20,153 25,361 through profit and loss
Other 3,439 2,205 Biological assets 263 222
Total current liabilities 14,781 12,909 Total current assets 64,111 65,420
Non-current liabilities Non-current assets
Borrowings 24,970 19,407 Property, plant and 108,664 104,602 equipment Derivative financial 600 653 instruments Intangibles and others 398 287
Provisions 1,137 857 Total non-current assets 109,062 104,889
Other 1,264 1,345 Total assets 173,173 170,309
Total non-current liabilities 27,971 22,262
2014 2013 FUNDS Total liabilities 42,752 35,171 ($’000) ($’000)
Net assets 130,421 135,138 Reserves 61,910 65,963
The Statement of Financial Position provided above, together with Retained surpluses 68,511 69,175 the attached Income Statement, have been extracted from the audited general purpose financial statements of Garvan Institute Total funds 130,421 135,138 of Medical Research and its controlled entities. The summary financial information does not include all the information and notes normally included in a statutory financial report. The audited general purpose financial report can be obtained upon request to the Chief Operating Officer.
The statutory financial report (from which the summary financial information has been extracted) has been prepared in Garvan Institute of Medical Research · Foundation Annual Report 2014 Financial Highlights accordance with the requirements of the Corporations Act 2001, Australian Charities and Non-for-profits Commission Act 2012 and Regulations 2013, Australian Accounting Standards and other authoritative pronouncements of the Australian Accounting Standards Board.
GARVAN 51 Garvan Institute of Medical Research 384 Victoria Street, Darlinghurst NSW, 2010 T + 61 2 9295 8100 F + 61 2 9295 8101 Design Sherlock Creative Principal photography Penelope Clay Contributing photography Dr Niall Byrne, Cell Division Laboratory, Alex Craig, Nick Hall, Kevin Hogan, Dr William Hughes, Invasion and Metastasis Laboratory, Associate Professor Cecile King, L’Oréal Australia/ Darren Leigh Roberts, Helen McGuire and Paula Morris.
Published April 2015 Copies of the Annual Report can be obtained by contacting: Garvan Research Foundation [email protected] +61 2 9295 8110
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