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Abstract Book Alfred Health Week Research Poster Display 23 – 27 October 2017 Alfred Health Week Research Poster Display 23 – 27 October 2017 The Alfred Hospital ABSTRACT BOOK ALFRED HEALTH WEEK RESEARCH POSTER DISPLAY 23 – 27 OCTOBER 2017 RESEARCH DAY Tuesday, 24 October 2016, 12:00 PM – 1:00 PM AMREP Lecture Theatre 2017 KEYNOTE SPEAKER: The Hon. John Brumby AO Former Premier of Victoria, Chair, Foundation Committee, Global Health Alliance Melbourne; Faculty of Business and Economics, University of Melbourne “To the Bedside and Beyond: Medical Research and Victoria’s Future” 1 POSTER PRIZES Michael J Hall Memorial Prize for Respiratory Physiology Professor Daniel Czarny Prize for Allergy, Asthma and Clinical Immunology Research Lucy Battistel Prize for Allied Health Research Henrietta Law Memorial Prize for Allied Health Research Burnet Institute Prize for Infectious Diseases Research Monash Comprehensive Cancer Consortium Prize for Cancer Research Noel and Imelda Foster Prize for Cardiovascular Research Baker Heart and Diabetes Institute Prize for Cardiovascular Research Baker Heart and Diabetes Institute Prize for Diabetes Research Senior Medical Staff Prize for Basic Science/Laboratory-Based Research Senior Medical Staff Prizes for Clinical/Public Health Research Tony Charlton Prize for Cardiac Surgical Research Monash Alfred Psychiatry Research Centre Prize for Psychiatry Research The Greg Barclay Nursing Research Award The Senior Medical Staff Award 2 CONTENTS CATEGORY PAGE ALLERGY / ASTHMA / IMMUNITY 1. HOW DO THE PROXIMAL AND PERIPHERAL ASTHMATIC AIRWAYS RESPOND WHEN PROVOKED 15 DIRECTLY AND INDIRECTLY? Dharmakumara M, Stuart-Andrews C, Zubrinich C, Thompson B 2. ACINAR VENTILATION HETEROGENEITY IS INCREASED IN IDIOPATHIC PULMONARY FIBROSIS 15 (IPF) AND COMBINED PULMONARY FIBROSIS AND EMPHYSEMA (CPFE) Ellis M, Prasad J, Westall G, Thompson B 3. MEDICATION- RELATED ANAPHYLAXIS: NON-ANTIMICROBIAL DRUGS IMPLICATED, PATIENT 16 OUTCOMES AND MANAGEMENT LESSONS Graudins LV, Zubrinich C, Aung AK 4. PRESEASONAL ORALAIR® IN AT RISK INDIVIDUALS CONFERS PROTECTION FROM EPIDEMIC 16 THUNDERSTORM ASTHMA Varese N, Deckert K, Zubrinich C, Van Zelm MC, Rolland JM, Hew M, O'Hehir RE ANAESTHESIA AND PERIOPERATIVE MEDICINE 5. A RANDOMIZED AND CONTROLLED STUDY COMPARING INTRA-OPERATIVE PATIENT 17 CONTROLLED SEDATION VERSUS RADIOLOGIST CONTROLLED SEDATION USING MIDAZOLAM AND FENTANYL, FOR PATIENTS UNDERGOING INSERTION OF A CENTRAL VENOUS LINE Clements WJ, Kavnoudias H, Daly D, Bui TV, Joseph T, Sneddon D, Tasiopoulos C, Williamson R, Snow T 6. SUBCONJUNCTIVAL DEXAMETHASONE FOR THE PREVENTION OF CYSTOID MACULAR OEDEMA IN ROUTINE CATARACT SURGERY: A RANDOMISED, CONTROLLED TRIAL 17 Kocak ED, van der Straaten D, Hall AJ 7. COMPLICATIONS WITH OSSEOINTEGRATION IN TRANSHUMERAL AMPUTEES 18 Sreedharan S, Pak K, Gray S, Bruscino-Raiola F 8. VALIDATION OF DAYS AT HOME AS AN OUTCOME MEASURE AFTER SURGERY: A PROSPECTIVE 18 COHORT Myles PS, Shulman MA, Heritier S, Wallace S, McIlroy DR, McCluskey S, Sillar I, Forbes A BURNS 9. THE IMPORTANCE OF INDIRECT CALORIMETRY IN THE MANAGEMENT OF NUTRITION IN MAJOR 19 BURNS: A RETROSPECTIVE STUDY Leung J, King S, Paul E, Ihle J, Ridley E, Cleland H CANCER RESEARCH 10. TUMOUR MUTATION STATUS AND SITES OF METASTASIS IN PATIENTS WITH CUTANEOUS 19 MELANOMA Adler NR, Wolfe R, Kelly JW, Haydon A, McArthur GA, McLean CA, Mar VJ 11. NEUTROPHIL TO LYMPHOCYTE RATIO (NLR) AS AN INDEPENDENT PROGNOSTIC MEASURE IN 20 PATIENTS RECEIVING TARGETED THERAPY OR IMMUNOTHERAPY FOR STAGE IV MELANOMA Blackley E, Lim LE, Moore M, Voskoboynik M, McLean C, Haydon A 12. EPIDEMIOLOGY OF PRIMARY INTRAOCULAR AND PRIMARY CENTRAL NERVOUS SYSTEM 20 LYMPHOMA IN VICTORIA Hall AJ, Kocak ED 3 13. RESULTS FROM THE UPPER GASTROINTESTINAL CANCER REGISTRY PANCREATIC CANCER 21 MODULE PILOT Heriot N, Zalcberg J, Croagh D, Holland J, Scarborough R, Greehill E, Ioannou L, Maharaj A on behalf of the Upper Gastrointestinal Cancer Registry Hepatopancreatobiliary Working Party and Steering Committee 14. A 7-YEAR REVIEW OF PAPILLARY THYROID CARCINOMA PATIENTS WITH COMPARTMENTAL 21 LYMPH NODE DISSECTION Johari Y, Serpell J, Yeung M, Grodski S, Lee JC 15. TOWARD DEFINING CELLS-OF-ORIGIN AND GENETIC ABERRATIONS IN MELANOCYTE 22 TRANSFORMATION Noguchi F, Szeto P, Fedele C, Peng A, Zhang YF, Shackleton M 16. SCREENING FOR PSYCHOSOCIAL DISTRESS IN LUNG CANCER: DEFINING THE UNMET GAPS.SCREENING FOR PSYCHOSOCIAL DISTRESS IN LUNG CANCER: DEFINING THE UNMET 22 GAPS Stirling RG, Wasiak J, Earnest A, Brand M, Holt N, Mansfield L, Mott H, Gooi J, Ruben J, Moore M, McInerney M, Li C and Evans S 17. RUPTURED HEPATOCELLULAR CARCINOMA: DEMOGRAPHICS, PREDICTORS AND CLINICAL 23 OUTCOMES IN AN AUSTRALIAN TERTIARY CENTER Tan N, Majeed A, Roberts S, Kemp W 24 18. TARGETING ACTIVATED PLATELETS: A UNIQUE AND POTENTIALLY UNIVERSAL APPROACH FOR CANCER IMAGING Yap ML, McFadyen JD, Wang X, Zia NA, Hohmann JD, Ziegler M, Yao Y, Pham A, Harris M, Donnelly PS, Hogarth PM, Pietersz GA, Lim B, Peter K CARDIOVASCULAR DISEASES 19. EVOLVING AUSTRALIAN TRENDS IN PROCEDURAL CHARACTERISTICS AND CLINICAL 24 OUTCOMES IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION FOR ST- ELEVATION MYOCARDIAL INFARCTION Biswas S, Duffy SJ, Lefkovits J, Andrianopoulos N, Brennan A, Walton A, Chan W, Norman S, Shaw J, Dawson L, Ajani A, Clark DJ, Freeman M, Hier C, Oqueli E, Reid C, Stub D 20. MODIC CHANGES ON MRI, AND SMOKING PREDICT VASCULAR ADHERENCE DURING ANTERIOR 25 LUMBAR EXPOSURE Claydon M, Johnson N, Malham G, Parker R 21. INTERDISCIPLINARY APPROACHES TO CHRONIC DISEASE: COPD AND HEART FAILURE Dimmock 25 T, Campbell J, Easton K, Hopper I, Newnham H, Sandford M, Kaye D, Bergin P, Yip G, Miller B, Luckhoff C 22. A SYSTEMS-BIOLOGY APPROACH TO IDENTIFYING AND CHARACTERISING A NOVEL REGULATOR OF LIPID METABOLISM 26 Keating MF, de Aguiar Vallim TQ, Parker BL, Tarling EJ, Zerenturk EJ, Liu Y, Lusis AJ, Almeida M, Peralta J, Curran JE, Blangero J, Meikle PJ, James DE, Drew BG, Calkin AC 23. NON-OPERATIVE MANAGEMENT OF CAVAL INJURY FOLLOWING COMPLICATED INFERIOR VENA CAVA FILTER RETRIEVAL 26 Lee JT, Goh G, Koukounaras J, Joseph T, Clements W 24. ABNORMAL DIASTOLOGY PREDICTS LONG TERM FUNCTIONAL OUTCOME AND RE- HOSPITALISATION IN PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE IMPLANTATION 27 Mundisugih J, Kaye D, Duffy S, Walton T, Nanayakkara S 25. TARGETED THROMBOLYSIS: NOVEL, INNOVATIVE, RISK-FREE AND SITE SPECIFIC DELIVERY OF AN ANTI-THROMBOTIC THERAPEUTIC 28 Wang X, Searle AK, Yao Y, Peter K 4 26. GARCINIA KOLA – AFRICAN ETHNO MEDICATION WITH ANTI-ATHEROSCLEROTIC EFFECTS? 28 Wallert M, Heise J, Chen YC, Kluge S, Schmölz L, Schubert M, Searle AK, Koeberle A, Galli F, Werz O, Birringer M, Lorkowski S, Peter K 27. VCP979, A NOVEL P38MAPK INHIBITOR, ATTENUATES INFLAMMATORY RESPONSE AND 29 IMPROVE CARDIAC FUNCTION POST-MYOCARDIAL INFARCTION Wang BH, Xu T, Huang L, Cai Y, Vinh N, Ma Y, Min S, Wang K, Scammells P, Ju S, Krum H 28. IMPACT OF PRE-PROCEDURAL BLOOD PRESSURE ON LONG-TERM OUTCOMES FOLLOWING 30 PERCUTANEOUS CORONARY INTERVENTION Warren J, Nanayakkara S, Andrianopoulos N, Brennan A, Reid C, Selkrig L, Shaw J, Clark D, Hiew C, Ajani A, Freeman M, Kingwell B, Dart AM, Duffy SJ 29. PATTERNS OF STRUCTURAL REMODELLING IN ADULTS RECEIVING AXIAL VERSUS 31 CENTRIFUGAL MECHANICAL ASSIST DEVICES Willam JB, Nanayakkara S, Mak V, Patel H, Kaye DM 30. MOLECULAR TARGETING OF INFLAMMATION FOR DIAGNOSIS AND THERAPY 31 Yu E, Diehl P, Siegel P, Wang X, Peter K DIABETES / DIABETIC COMPLICATIONS 31. GENE THERAPY TARGETING THE HEXOSAMINE BIOSYNTHESIS PATHWAY (HBP) ATTENUATES 32 MARKERS OF DIABETIC CARDIOMYOPATHY IN A MODEL OF TYPE-2 DIABETES (T2D) Cohen C, De Blasio M, Kemp-Harper B, Ritchie R 32. IMPROVING SKELETAL MUSCLE MITOCHONDRIAL TURNOVER TO COMBAT INSULIN 32 RESISTANCE King EJ, Calkin AC, Liu Y, Henstridge DC, Drew BG 33. LOWERING OXIDATIVE STRESS AND NLRP3-INFLAMMASOME ACTIVITY BY NRF2 ACTIVATORS 33 LESSENS MACROPHAGE CYTOKINE PRODUCTION AND IMPROVES DIABETES-ASSOCIATED ATHEROSCLEROSIS: A NOVEL THERAPEUTIC STRATEGY FOR DIABETIC VASCULAR COMPLICATIONS Sharma A, Mathew G, Vince J, Pickering R, Tan SM, Ward K, de Haan J 34. RESISTANT STARCH AMELIORATES ADVANCED GLYCATION ENDPRODUCT-INDUCED 33 ALBUMINURIA IN A MOUSE MODEL OF TYPE 2 DIABETES Snelson M, Tan SM, Sourris K, Higgins G, Ding Y, Lindblom R, Nguyen TV, Thallas-Bonke V, Cooper ME, Coughlan MT 35. NOVEL THERAPEUTIC USE OF ANNEXIN-A1 MIMETICS TO TREAT DIABETIC CARDIOMYOPATHY 34 Walsh J, Qin C, Ritchie R, Tare M 36. SYSTEMIC AND CARDIAC-SELECTIVE TARGETING OF THE HDAC4 PATHWAY TO LIMIT 35 DIABETES-INDUCED CARDIOMYOPATHY Willis A, Tate M, Tare M, Ritchie R ENDOCRINOLOGY 37. ROUTINE PRE-THYROIDECTOMY LARYNGOSCOPY IS NOT NECESSARY IN THE ERA OF 35 INTRAOPERATIVE NEUROMONITORING Goare S, Maher D, Grodski S, Serpell J, Lee JC 38. RISK FACTORS AFFECTING RECURRENCE-FREE SURVIVAL IN FOLLICULAR THYROID 36 CARCINOMA PATIENTS: A 15-YEAR REVIEW Lu L, Lee J, Grodski S, Yeung M, Serpell J 39. THYROIDECTOMY THEN AND NOW - A 50-YEAR AUSTRALIAN PERSPECTIVE 36 Hii B, Maher DI, Yeung M, Serpell JW, Lee JC 5 GASTROENTROLOGY 40. THE UTILITY OF SERUM ZONULIN, THE "LEAKY GUT" PROTEIN, AS A MARKER OF 37 GASTROINTESTINAL DYSFUNCTION Ajamian M, Rosella G, Muir JG, Gibson PR 41. LONG-TERM OUTCOMES OF PRIMARY SCLEROSING CHOLANGITIS: AN AUSTRALIAN TERTIARY 37 HOSPITAL PERSPECTIVE Freeman E, Kemp W, Roberts SK 42. A MODEL TO IDENTIFY PATIENTS AT INCREASED RISK OF LIVER FIBROSIS IN NON-ALCOHOLIC 38 FATTY LIVER DISEASE Hannah N, Kemp W, Majeed A, Roberts SK 43. OUTCOME OF PATIENTS WITH CARDIAC HEPATOPATHY UNDERGOING HEART 39 TRANSPLANTATION – PRELIMINARY ANALYSIS Ngu N, Majeed A, Roberts SK, Bergin P, Kemp W HAEMATOLOGY 44. APPLICATION OF A NOVEL HAEMOCOMAPATIBILITY PROFILING APPROACH FOR THE 40 DEVELOPMENT OF BLOOD HANDLING MICRO-VALVES FOR LAB-ON-CHIP DIAGNOSTICS Brazilek RJ, Szydzik C, Khoshmanesh K, Thurgood P, Akbaridoust F, Marusic I, Nandurkar H, Mitchell A, Nesbitt W 45. DEVELOPMENT OF ELASTOMERIC SUBSTRATES TO INVESTIGATE THE IMPACT OF 40 SUBENDOTHELIAL EXTRACELLULAR MATRIX STIFFNESS ON PLATELET FUNCTION Firipis K, Muir I, Griffith J, Dagastine R, Mitchell A, Nandurkar H, Nesbitt W 46.
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