BJD CONCISE COMMUNICATION British Journal of Dermatology A randomized, double-blind, placebo- and active-controlled, half-head study to evaluate the effects of platelet-rich plasma on alopecia areata A. Trink,1 E. Sorbellini,1 P. Bezzola,1 L. Rodella,2 R. Rezzani,2 Y. Ramot3 and F. Rinaldi1 1International Hair Research Foundation (IHRF), Milan, Italy 2University of Brescia, Brescia, Italy 3Department of Dermatology, Hadassah – Hebrew University Medical Center, Jerusalem, Israel Summary Correspondence Background Alopecia areata (AA) is a common autoimmune condition, causing Fabio Rinaldi. inflammation-induced hair loss. This disease has very limited treatment possibili- E-mail:
[email protected] ties, and no treatment is either curative or preventive. Platelet-rich plasma (PRP) has emerged as a new treatment modality in dermatology, and preliminary evi- Accepted for publication 16 April 2013 dence has suggested that it might have a beneficial role in hair growth. Objectives To evaluate the efficacy and safety of PRP for the treatment of AA in a Funding sources randomized, double-blind, placebo- and active-controlled, half-head, parallel- None. group study. Methods Forty-five patients with AA were randomized to receive intralesional Conflicts of interest injections of PRP, triamcinolone acetonide (TrA) or placebo on one half of None declared. their scalp. The other half was not treated. Three treatments were given for each DOI 10.1111/bjd.12397 patient, with intervals of 1 month. The endpoints were hair regrowth, hair dystrophy as measured by dermoscopy, burning or itching sensation, and cell proliferation as measured by Ki-67 evaluation. Patients were followed for 1 year.