1 Significance of Serglycin and Its Binding Partners in Autocrine Promotion of Metastasis In
1 Significance of serglycin and its binding partners in autocrine promotion of metastasis in 2 esophageal cancer 3 Yun Zhu1, Alfred K.Y. Lam2, Daisy K.Y. Shum1, Di Cui1, Jun Zhang1, Dong Dong Yan1, Bin 4 Li3, Wen Wen Xu4, Nikki P.Y. Lee5, Kin Tak Chan5, Simon Law5, Sai Wah Tsao1, Annie 5 L.M. Cheung1, *. 6 1 School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong 7 Kong, Hong Kong SAR, China 8 2 Department of Pathology, Griffith Medical School, Queensland, Gold Coast, QLD, 9 Australia 10 3 MOE Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional 11 Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health 12 Engineering, Jinan University, Guangzhou, China 13 4 MOE Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key 14 Laboratory of Bioengineering Medicine, National Engineering Research Center of Genetic 15 Medicine, Institute of Biomedicine, College of Life Science and Technology, Jinan 16 University, Guangzhou, China 17 5 Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong 18 Kong SAR, China 19 * Corresponding Author: Annie L.M. Cheung, School of Biomedical Sciences, Li Ka Shing 20 Faculty of Medicine, University of Hong Kong, 21 Sassoon Road, Hong Kong SAR, China. 21 Phone: 852-3917-9293; Fax: 852-2817-0857; e-mail: lmcheung@hku.hk 22 Running title: Significance of SRGN and its binding partner MDK in ESCC 1 23 Keywords: Serglycin, midkine, esophageal squamous cell carcinoma, metastasis, biomarker 24 Financial support: General Research Fund from the Research Grants Council of the Hong 25 Kong SAR, China (Project Nos.
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