Smith Bacterial SBP56 Identified As a Cu-Dependent Methanethiol
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Methyl Mercaptan
Methyl Mercaptan Methyl Mercaptan (CH3SH) CAS 74-93-1; UN 1064 Synonyms include methanethiol, mercaptomethane, thiomethanol, methyl sulfhydrate, and thiomethyl alcohol. • Persons exposed only to methyl mercaptan pose little risk of secondary contamination to personnel outside the Hot Zone. • Methyl mercaptan is a colorless flammable gas with unpleasant odor described as rotten cabbage. It is easily ignited. When heated to decomposition, it emits highly toxic fumes and flammable vapors. Vapors from liquified methyl mercaptan gas are heavier than air and may collect in low-lying areas. Olfactory fatigue may prevent adequate warning of hazardous concentrations. • Methyl mercaptan is highly irritant when it contacts moist tissues such as the eyes, skin, and upper respiratory tract. It can also induce headache, dizziness, nausea, vomiting, coma, and death. Ingestion of methyl mercaptan is unlikely since it is a gas at ambient temperatures. Description At room temperature (above 43 °F), methyl mercaptan is a colorless gas with an unpleasant odor described as rotten cabbage. It is slightly soluble in water. It is generally shipped as a liquified compressed gas. When heated to decomposition, it emits toxic fumes, such as sulfur dioxide, and flammable vapors. Methyl mercaptan should be stored in cool, well ventilated places. The main toxic effect of exposure to methyl mercaptan is irritation of the respiratory airway, skin, and eyes. Routes of Exposure Inhalation Inhalation is the major route of exposure to methyl mercaptan. An odor threshold of 0.002 ppm has been reported for methyl mercaptan, but olfactory fatigue may occur and thus, it may not provide adequate warning of hazardous concentrations. -
Finite Element Modelling of Bandgap Engineered Graphene FET with the Application in Sensing Methanethiol Biomarker
sensors Article Finite Element Modelling of Bandgap Engineered Graphene FET with the Application in Sensing Methanethiol Biomarker Paramjot Singh , Parsoua Abedini Sohi and Mojtaba Kahrizi * Department of Electrical and Computer Engineering, Concordia University, Montreal, QC H3G1M8, Canada; [email protected] (P.S.); [email protected] (P.A.S.) * Correspondence: [email protected]; Tel.: +1-51-48-482-424 (ext. 3089) Abstract: In this work, we have designed and simulated a graphene field effect transistor (GFET) with the purpose of developing a sensitive biosensor for methanethiol, a biomarker for bacterial infections. The surface of a graphene layer is functionalized by manipulation of its surface structure and is used as the channel of the GFET. Two methods, doping the crystal structure of graphene and decorating the surface by transition metals (TMs), are utilized to change the electrical properties of the graphene layers to make them suitable as a channel of the GFET. The techniques also change the surface chemistry of the graphene, enhancing its adsorption characteristics and making binding between graphene and biomarker possible. All the physical parameters are calculated for various variants of graphene in the absence and presence of the biomarker using counterpoise energy-corrected density functional theory (DFT). The device was modelled using COMSOL Multiphysics. Our studies show that the sensitivity of the device is affected by structural parameters of the device, the electrical properties of the graphene, and with adsorption of the biomarker. It was found that the devices made of graphene layers decorated with TM show higher sensitivities toward detecting the biomarker compared with those made by doped graphene layers. -
PROVISIONAL PEER REVIEWED TOXICITY VALUES for METHYL MERCAPTAN (CASRN 74-93-1) Derivation of Subchronic and Chronic Oral Rfds
EPA/690/R-04/010F l Final 12-20-2004 Provisional Peer Reviewed Toxicity Values for Methyl Mercaptan (CASRN 74-93-1) Derivation of Subchronic and Chronic Oral RfDs Superfund Health Risk Technical Support Center National Center for Environmental Assessment Office of Research and Development U.S. Environmental Protection Agency Cincinnati, OH 45268 Acronyms and Abbreviations bw body weight cc cubic centimeters CD Caesarean Delivered CERCLA Comprehensive Environmental Response, Compensation and Liability Act of 1980 CNS central nervous system cu.m cubic meter DWEL Drinking Water Equivalent Level FEL frank-effect level FIFRA Federal Insecticide, Fungicide, and Rodenticide Act g grams GI gastrointestinal HEC human equivalent concentration Hgb hemoglobin i.m. intramuscular i.p. intraperitoneal i.v. intravenous IRIS Integrated Risk Information System IUR inhalation unit risk kg kilogram L liter LEL lowest-effect level LOAEL lowest-observed-adverse-effect level LOAEL(ADJ) LOAEL adjusted to continuous exposure duration LOAEL(HEC) LOAEL adjusted for dosimetric differences across species to a human m meter MCL maximum contaminant level MCLG maximum contaminant level goal MF modifying factor mg milligram mg/kg milligrams per kilogram mg/L milligrams per liter MRL minimal risk level i MTD maximum tolerated dose MTL median threshold limit NAAQS National Ambient Air Quality Standards NOAEL no-observed-adverse-effect level NOAEL(ADJ) NOAEL adjusted to continuous exposure duration NOAEL(HEC) NOAEL adjusted for dosimetric differences across species to a -
Anaerobic Degradation of Methanethiol in a Process for Liquefied Petroleum Gas (LPG) Biodesulfurization
Anaerobic degradation of methanethiol in a process for Liquefied Petroleum Gas (LPG) biodesulfurization Promotoren Prof. dr. ir. A.J.H. Janssen Hoogleraar in de Biologische Gas- en waterreiniging Prof. dr. ir. A.J.M. Stams Persoonlijk hoogleraar bij het laboratorium voor Microbiologie Copromotor Prof. dr. ir. P.N.L. Lens Hoogleraar in de Milieubiotechnologie UNESCO-IHE, Delft Samenstelling promotiecommissie Prof. dr. ir. R.H. Wijffels Wageningen Universiteit, Nederland Dr. ir. G. Muyzer TU Delft, Nederland Dr. H.J.M. op den Camp Radboud Universiteit, Nijmegen, Nederland Prof. dr. ir. H. van Langenhove Universiteit Gent, België Dit onderzoek is uitgevoerd binnen de onderzoeksschool SENSE (Socio-Economic and Natural Sciences of the Environment) Anaerobic degradation of methanethiol in a process for Liquefied Petroleum Gas (LPG) biodesulfurization R.C. van Leerdam Proefschrift ter verkrijging van de graad van doctor op gezag van de rector magnificus van Wageningen Universiteit Prof. dr. M.J. Kropff in het openbaar te verdedigen op maandag 19 november 2007 des namiddags te vier uur in de Aula Van Leerdam, R.C., 2007. Anaerobic degradation of methanethiol in a process for Liquefied Petroleum Gas (LPG) biodesulfurization. PhD-thesis Wageningen University, Wageningen, The Netherlands – with references – with summaries in English and Dutch ISBN: 978-90-8504-787-2 Abstract Due to increasingly stringent environmental legislation car fuels have to be desulfurized to levels below 10 ppm in order to minimize negative effects on the environment as sulfur-containing emissions contribute to acid deposition (‘acid rain’) and to reduce the amount of particulates formed during the burning of the fuel. Moreover, low sulfur specifications are also needed to lengthen the lifetime of car exhaust catalysts. -
Protein Targets of Acetaminophen Covalent Binding in Rat and Mouse
ORIGINAL RESEARCH published: XX XX 2021 doi: 10.3389/fchem.2021.736788 1 58 2 59 3 60 4 61 5 62 6 63 7 64 8 65 9 66 10 Protein Targets of Acetaminophen 67 11 68 12 Covalent Binding in Rat and Mouse 69 13 70 14 Q2 Liver Studied by LC-MS/MS 71 15 Q3 72 Q1 16 Timon Geib, Ghazaleh Moghaddam, Aimee Supinski, Makan Golizeh† and Lekha Sleno* Q4 73 17 Q5 74 18 Chemistry Department, Université du Québec à Montréal, Montréal, QC, Canada Q6 75 19 76 20 Acetaminophen (APAP) is a mild analgesic and antipyretic used commonly worldwide. 77 21 78 Although considered a safe and effective over-the-counter medication, it is also the leading 22 79 23 cause of drug-induced acute liver failure. Its hepatotoxicity has been linked to the covalent 80 24 binding of its reactive metabolite, N-acetyl p-benzoquinone imine (NAPQI), to proteins. The 81 Edited by: 25 aim of this study was to identify APAP-protein targets in both rat and mouse liver, and to 82 26 Marcus S Cooke, 83 University of South Florida, compare the results from both species, using bottom-up proteomics with data-dependent 27 United States 84 28 high resolution mass spectrometry and targeted multiple reaction monitoring (MRM) 85 Reviewed by: 29 experiments. Livers from rats and mice, treated with APAP, were homogenized and 86 Hartmut Jaeschke, 30 University of Kansas Medical Center digested by trypsin. Digests were then fractionated by mixed-mode solid-phase extraction 87 31 Research Institute, United States prior to liquid chromatography-tandem mass spectrometry (LC-MS/MS). -
Sodium Methyl Mercaptide Version 1.11 Revision Date 2020-08-26
SAFETY DATA SHEET Sodium Methyl Mercaptide Version 1.11 Revision Date 2020-08-26 According to Regulation (EC) No. 1907/2006, Regulation (EC) No. 2015/830 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1 Product information Product Name : Sodium Methyl Mercaptide Material : 1114147, 1114146, 1114145, 1065936, 1066239, 1030037, 1029154, 1029192, 1034903 1.3 Details of the supplier of the safety data sheet Company : Chevron Phillips Chemical Company LP Specialty Chemicals 10001 Six Pines Drive The Woodlands, TX 77380 Local : Chevron Phillips Chemicals International N.V. Airport Plaza (Stockholm Building) Leonardo Da Vincilaan 19 1831 Diegem Belgium SDS Requests: (800) 852-5530 Technical Information: (832) 813-4862 Responsible Party: Product Safety Group Email:[email protected] 1.4 Emergency telephone: Health: 866.442.9628 (North America) 1.832.813.4984 (International) Transport: CHEMTREC 800.424.9300 or 703.527.3887(int'l) Asia: CHEMWATCH (+612 9186 1132) China: 0532 8388 9090 EUROPE: BIG +32.14.584545 (phone) or +32.14583516 (telefax) Mexico CHEMTREC 01-800-681-9531 (24 hours) South America SOS-Cotec Inside Brazil: 0800.111.767 Outside Brazil: +55.19.3467.1600 Argentina: +(54)-1159839431 Responsible Department : Product Safety and Toxicology Group SDS Number:100000013985 1/17 SAFETY DATA SHEET Sodium Methyl Mercaptide Version 1.11 Revision Date 2020-08-26 E-mail address : [email protected] Website : www.CPChem.com SECTION 2: Hazards identification 2.1 Classification of the substance or mixture REGULATION (EC) No 1272/2008 Flammable liquids, Category 3 H226: Flammable liquid and vapor. Acute toxicity, Category 4 H302: Harmful if swallowed. -
Volatile Sulfur Compounds in Coastal Acid Sulfate Soils, Northern N.S.W
VOLATILE SULFUR COMPOUNDS IN COASTAL ACID SULFATE SOILS, NORTHERN N.S.W Andrew Stephen Kinsela A thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy School of Biological, Earth & Environmental Sciences THE UNIVERSITY OF NEW SOUTH WALES, AUSTRALIA 2007 DECLARATION ORIGINALITY STATEMENT ‘I hereby declare that this submission is my own work and to the best of my knowledge it contains no materials previously published or written by another person, or substantial proportions of material which have been accepted for the award of any other degree or diploma at UNSW or any other educational institution, except where due acknowledgement is made in the thesis. Any contribution made to the research by others, with whom I have worked at UNSW or elsewhere, is explicitly acknowledged in the thesis. I also declare that the intellectual content of this thesis is the product of my own work, except to the extent that assistance from others in the project's design and conception or in style, presentation and linguistic expression is acknowledged.’ Signed ………………………………………………… Date …………………………………………………… iii ACKNOWLEDGEMENTS There are numerous people who have assisted me throughout the course of my thesis. I therefore want to take this opportunity to thank a few of those who contributed appreciably, both directly and indirectly. First of all, I would like to express my heartfelt gratitude to my supervisor, Associate Professor Mike Melville. Mike’s initial teachings as part of my undergraduate studies first sparked my interest in soils. Since then his continued enthusiasm on the subject has helped shape the way I approach my own work. -
Dynamic Changes in the Urine Proteome in Two Ovarian Cancer Rat
bioRxiv preprint doi: https://doi.org/10.1101/604850; this version posted April 10, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Dynamic changes in the urine proteome in two ovarian cancer rat models Yuqiu Li 1,2, Linpei Zhang1,2, Wenshu Meng 1,2, Youhe Gao *1,2 1. Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing 100875; 2. Gene Engineering Drug and Biotechnology Beijing Key Laboratory, Beijing 100875 *Corresponding author: Youhe Gao Email: [email protected] Phone: 86-10-5880-4382; Fax: 86-10-6521-2284 Abstract: Ovarian cancer is the most lethal gynecological malignancy in women, and it is likely to metastasize and has a poor prognosis. The early and reliable diagnosis and monitoring of ovarian cancer is very important. Without a homeostasis mechanism, urine can reflect early systemic changes in the body and has a great potential to be used for the early detection of cancer. This study tested whether early changes could be detected in two ovarian cancer rat models. Two rat models were established by either intraperitoneal (i.p.) or orthotopic (o.t.) injection of NuTu-19 ovarian cancer cells in female Fischer344 rats. Urine samples from ovarian cancer rats were collected at five time points during cancer development, and urinary proteins from the rats were profiled by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Compared with pre-injection samples, 49 differential proteins that have human orthologues were significantly changed in the orthotopically injected model. -
Methanethiol-Dependent Dimethylsulfide Production in Soil Environments
OPEN The ISME Journal (2017) 11, 2379–2390 www.nature.com/ismej ORIGINAL ARTICLE Methanethiol-dependent dimethylsulfide production in soil environments Ornella Carrión1, Jennifer Pratscher2, Andrew RJ Curson1, Beth T Williams1, Wayne G Rostant1, J Colin Murrell2 and Jonathan D Todd1 1School of Biological Sciences, University of East Anglia, Norwich, UK and 2School of Environmental Sciences, University of East Anglia, Norwich, UK Dimethylsulfide (DMS) is an environmentally important trace gas with roles in sulfur cycling, signalling to higher organisms and in atmospheric chemistry. DMS is believed to be predominantly produced in marine environments via microbial degradation of the osmolyte dimethylsulfoniopro- pionate (DMSP). However, significant amounts of DMS are also generated from terrestrial environments, for example, peat bogs can emit ~ 6 μmol DMS m − 2 per day, likely via the methylation of methanethiol (MeSH). A methyltransferase enzyme termed ‘MddA’, which catalyses the methylation of MeSH, generating DMS, in a wide range of bacteria and some cyanobacteria, may mediate this process, as the mddA gene is abundant in terrestrial metagenomes. This is the first study investigating the functionality of MeSH-dependent DMS production (Mdd) in a wide range of aerobic environments. All soils and marine sediment samples tested produced DMS when incubated with MeSH. Cultivation-dependent and cultivation-independent methods were used to assess microbial community changes in response to MeSH addition in a grassland soil where 35.9% of the bacteria were predicted to contain mddA. Bacteria of the genus Methylotenera were enriched in the presence of MeSH. Furthermore, many novel Mdd+ bacterial strains were isolated. Despite the abundance of mddA in the grassland soil, the Mdd pathway may not be a significant source of DMS in this environment as MeSH addition was required to detect DMS at only very low conversion rates. -
Articles, Which Are Known to Influence Clouds and (Nguyen Et Al., 1983; Andreae Et Al., 1985; Andreae, 1990; Climate, Atmospheric Chemical Processes
Atmos. Meas. Tech., 9, 1325–1340, 2016 www.atmos-meas-tech.net/9/1325/2016/ doi:10.5194/amt-9-1325-2016 © Author(s) 2016. CC Attribution 3.0 License. Challenges associated with the sampling and analysis of organosulfur compounds in air using real-time PTR-ToF-MS and offline GC-FID Véronique Perraud, Simone Meinardi, Donald R. Blake, and Barbara J. Finlayson-Pitts Department of Chemistry, University of California, Irvine, CA 92697, USA Correspondence to: Barbara J. Finlayson-Pitts (bjfi[email protected]) and Donald R. Blake ([email protected]) Received: 10 November 2015 – Published in Atmos. Meas. Tech. Discuss.: 15 December 2015 Revised: 2 March 2016 – Accepted: 3 March 2016 – Published: 30 March 2016 Abstract. Organosulfur compounds (OSCs) are naturally 1 Introduction emitted via various processes involving phytoplankton and algae in marine regions, from animal metabolism, and from Organosulfur compounds (OSCs) such as methanethiol biomass decomposition inland. These compounds are mal- (CH3SH, MTO), dimethyl sulfide (CH3SCH3, DMS), odorant and reactive. Their oxidation to methanesulfonic and dimethyl disulfide (CH3SSCH3, DMDS), and dimethyl sulfuric acids leads to the formation and growth of atmo- trisulfide (CH3SSSCH3, DMTS) have been measured in air spheric particles, which are known to influence clouds and (Nguyen et al., 1983; Andreae et al., 1985; Andreae, 1990; climate, atmospheric chemical processes. In addition, par- Andreae et al., 1993; Aneja, 1990; Bates et al., 1992; Watts, ticles in air have been linked to negative impacts on vis- 2000; de Bruyn et al., 2002; Xie et al., 2002; Jardine et al., ibility and human health. Accurate measurements of the 2015). -
Molecular Changes in Tissue Proteome During Prostate Cancer Development: Proof-Of-Principle Investigation
diagnostics Article Molecular Changes in Tissue Proteome during Prostate Cancer Development: Proof-of-Principle Investigation Agnieszka Latosinska 1,*, Katarina Davalieva 2 , Manousos Makridakis 3, William Mullen 4 , Joost P. Schanstra 5,6, Antonia Vlahou 3, Harald Mischak 1 and Maria Frantzi 1 1 Mosaiques Diagnostics GmbH, 30659 Hannover, Germany; [email protected] (H.M.); [email protected] (M.F.) 2 Research Centre for Genetic Engineering and Biotechnology “Georgi D Efremov”, Macedonian Academy of Sciences and Arts, 1000 Skopje, North Macedonia; [email protected] 3 Biomedical Research Foundation of the Academy of Athens, Centre of Systems Biology, 11527 Athens, Greece; [email protected] (M.M.); [email protected] (A.V.) 4 Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK; [email protected] 5 Institut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institute of Cardiovascular and Metabolic Diseases, 31432 Toulouse, France; [email protected] 6 Université Toulouse III Paul-Sabatier, 31400 Toulouse, France * Correspondence: [email protected]; Tel.: +49-(0)51-15-547-4430; Fax: +49-(0)51-15-547-4431 Received: 30 July 2020; Accepted: 26 August 2020; Published: 31 August 2020 Abstract: (1) Background: Prostate cancer (PCa) is characterized by high heterogeneity. The aim of this study was to investigate molecular alterations underlying PCa development based on proteomics data. (2) Methods: Liquid chromatography coupled to tandem mass spectrometry was conducted for 22 fresh-frozen tissue specimens from patients with benign prostatic hyperplasia (BPH, n = 5) and PCa (n = 17). Mann Whitney test was used to define significant differences between the two groups. -
Structure and Spectroscopy of Methionyl-Methionine for Aquaculture
www.nature.com/scientificreports OPEN Structure and spectroscopy of methionyl‑methionine for aquaculture Stewart F. Parker1*, Nicholas P. Funnell1, Kenneth Shankland2, Elena A. Kabova2, Thomas Häußner3, Hans‑Joachim Hasselbach3, Sascha Braune3, Christoph Kobler3 & Peter W. Albers4* The amino acid l‑methionine is an essential amino acid and is commonly used as a feed supplement in terrestrial animals. It is less suitable for marine organisms because it is readily excreted. It is also highly water soluble and this results in loss of the feed and eutrophication of the water. To address these problems, the dipeptide dl‑methionyl‑dl‑methionine (trade name: AQUAVI Met‑Met) has been developed as a dedicated methionine source for aquaculture. The commercial product is a mixture of a racemic crystal form of d‑methionyl‑d‑methionine/l‑methionyl‑l‑methionine and a racemic crystal form of d‑methionyl‑l‑methionine/l‑methionyl‑d‑methionine. In this work, we have computationally, structurally, spectroscopically and by electron microscopy characterised these materials. The microscopy and spectroscopy demonstrate that there is no interaction between the dd–ll and dl–ld racemates on any length scale from the macroscopic to the nanoscale. Te amino acid l-methionine ((2S)‐2‐amino‐4‐(methylsulfanyl)butanoic acid, Fig. 1) is an essential amino acid i.e. it cannot be synthesised in vivo1. Te industrial synthesis of methionine from hydrogen cyanide, methanethiol and acrolein2 results in the racemate, whilst pure l-methionine can be obtained by fermentation3. However, dl- methionine is a valuable food additive in animal nutrition4, as the “unnatural” d-methionine diastereoisomer can be converted to the desired l-form physiologically5.