Report of Genemania Search

GeneMANIA http://www.genemania.org/print

Created on: 5 December 2012 00:37:59 Last database update: 19 July 2012 20:00:00 Application version: 3.1.1

Report of GeneMANIA search

Network image

PCNA

RRM2B BCL2

3.08 Functions legend Networks legend induction of apoptosis by intracellular signals Co-expression query genes Co-localization Genetic interactions Pathway Physical interactions Predicted Shared protein domains

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Search parameters

Organism: H. sapiens (human)

Genes: BID; IGF1; FAS; CASP8; TCOF1; GTSE1; TP73; CD82; BAX; GADD45B; TSC2; CCNE1; CDK6; UBTF; CCND1; PERP; CCNG1; CCND2; APAF1; CDK2; CDKN1A; GADD45G; SESN2; CASP9; CCNB1; CDK4; THBS1; CCNG2; TP53; PMAIP1; CDKN2A; SESN3; EI24; CHEK1; CCNB2; CASP3; CDK1; POLR1C; RRM2; PTEN; CYCS; ZMAT3; ATR; CCNE2; SFN; LRDD; POLR1D; SIAH1A

Networks: Attributes:

Network weighting: Automatically selected weighting method (Assigned based on query genes)

Number of gene results: 20

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Networks

Predicted 27.86 % I2D-Tarassov-PCA-Yeast2Human 6.55 % An in vivo map of the yeast protein interactome. Tarassov et al. (2008). Science . Note: I2D predictions of protein protein interactions using Tarassov-Michnick-2008 Saccharomyces cerevisiae data Source: Direct interaction with 441 interactions from I2D Tags: cell proliferation

I2D-IntAct-Mouse2Human 4.34 % The IntAct molecular interaction database in 2010. Aranda et al. (2010). Nucleic Acids Res . Note: I2D predictions of protein protein interactions using IntAct Mus musculus data Source: Direct interaction with 3,422 interactions from I2D

I2D-MGI-Mouse2Human 3.32 % Ontological visualization of protein-protein interactions. Drabkin et al. (2005). BMC Bioinformatics . Note: I2D predictions of protein protein interactions using MGI Mus musculus data Source: Direct interaction with 724 interactions from I2D

I2D-BioGRID-Mouse2Human 3.06 % BioGRID: a general repository for interaction datasets. Stark et al. (2006). Nucleic Acids Res . Note: I2D predictions of protein protein interactions using BioGRID Mus musculus data Source: Direct interaction with 288 interactions from I2D

I2D-MINT-Rat2Human 2.78 % MINT: a Molecular INTeraction database. Zanzoni et al. (2002). FEBS Lett . Note: I2D predictions of protein protein interactions using MINT Rattus norvegicus data Source: Direct interaction with 574 interactions from I2D

I2D-INNATEDB-Mouse2Human 2.21 % InnateDB: facilitating systems-level analyses of the mammalian innate immune response. Lynn et al. (2008). Mol Syst Biol . Note: I2D predictions of protein protein interactions using INNATEDB Mus musculus data Source: Direct interaction with 1,455 interactions from I2D Tags: signal transduction; immune system

I2D-BIND-Mouse2Human 1.95 % BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al. (2000). Bioinformatics . Note: I2D predictions of protein protein interactions using BIND Mus musculus data Source: Direct interaction with 1,198 interactions from I2D

I2D-Giot-Rothbert-2003-High-Fly2Human 1.88 % A protein interaction map of Drosophila melanogaster. Giot et al. (2003). Science . Note: I2D predictions of protein protein interactions using Giot-Rothbert-2003 Drosophila melanogaster data Source: Direct interaction with 602 interactions from I2D Tags: cell proliferation; signal transduction; nervous system; immune system

I2D-BIND-Yeast2Human 0.78 % BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al. (2000). Bioinformatics . Note: I2D predictions of protein protein interactions using BIND Saccharomyces cerevisiae data Source: Direct interaction with 1,543 interactions from I2D

Stuart-Kim-2003 0.52 %

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A gene-coexpression network for global discovery of conserved genetic modules. Stuart et al. (2003). Science . Source: 24,952 interactions from supplementary material Tags: cell proliferation; cultured cells; signal transduction; cancer

I2D-Yu-Vidal-2008-GoldStd-Yeast2Human 0.25 % High-quality binary protein interaction map of the yeast interactome network. Yu et al. (2008). Science . Note: I2D predictions of protein protein interactions using Yu Gold Standard Saccharomyces cerevisiae data Source: Direct interaction with 386 interactions from I2D Tags: transcription factors; signal transduction

I2D-BIND-Fly2Human 0.21 % BIND--a data specification for storing and describing biomolecular interactions, molecular complexes and pathways. Bader et al. (2000). Bioinformatics . Note: I2D predictions of protein protein interactions using BIND Drosophila melanogaster data Source: Direct interaction with 2,625 interactions from I2D

Physical interactions 25.39 % Ramachandran-LaBaer-2004 14.50 % Self-assembling protein microarrays. Ramachandran et al. (2004). Science . Source: Direct interaction with 119 interactions from iRefIndex

IREF-CORUM 3.53 % Source: Direct interaction with 637 interactions from iRefIndex

IREF-MPPI 3.52 % Source: Direct interaction with 385 interactions from iRefIndex

IREF-DIP 1.95 % Source: Direct interaction with 12,700 interactions from iRefIndex

IREF-GRID 0.51 % Source: Direct interaction with 33,623 interactions from iRefIndex

IREF-INTACT 0.48 % Source: Direct interaction with 21,448 interactions from iRefIndex

Rual-Vidal-2005 B 0.42 % Towards a proteome-scale map of the human protein-protein interaction network. Rual et al. (2005). Nature . Note: One of 2 datasets produced from this publication. Source: Direct interaction with 2,624 interactions from iRefIndex

Rual-Vidal-2005 A 0.23 % Towards a proteome-scale map of the human protein-protein interaction network. Rual et al. (2005). Nature . Note: One of 2 datasets produced from this publication. Source: Direct interaction with 2,581 interactions from BioGRID

IREF-BIND 0.22 % Source: Direct interaction with 5,310 interactions from iRefIndex

BIOGRID-SMALL-SCALE-STUDIES 0.02 % Source: Direct interaction with 28,821 interactions from BioGRID

Hutchins-Peters-2010 0.01 % Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins et al. (2010). Science . Source: Direct interaction with 141 interactions from iRefIndex Tags: cell proliferation; nervous system; localization

Co-expression 15.99 %

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Nakayama-Hasegawa-2007 2.95 % Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma. Nakayama et al. (2007). Mod Pathol . Source: Pearson correlation with 361,398 interactions from GEO Tags: transcription factors; cancer

Rieger-Chu-2004 2.05 % Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage. Rieger et al. (2004). Proc Natl Acad Sci U S A . Source: Pearson correlation with 220,846 interactions from GEO Tags: cultured cells; cell line

Jones-Libermann-2005 1.80 % Gene signatures of progression and metastasis in renal cell cancer. Jones et al. (2005). Clin Cancer Res . Source: Pearson correlation with 365,428 interactions from GEO Tags: transcription factors; disease; cancer

Peng-Katze-2009 1.19 % Computational identification of hepatitis C virus associated microRNA-mRNA regulatory modules in human livers. Peng et al. (2009). BMC Genomics . Source: Pearson correlation with 349,954 interactions from GEO Tags: liver

Burington-Shaughnessy-2008 1.01 % Tumor cell gene expression changes following short-term in vivo exposure to single agent chemotherapeutics are related to survival in multiple myeloma. Burington et al. (2008). Clin Cancer Res . Source: Pearson correlation with 266,464 interactions from GEO Tags: transcription factors; time series; cancer; chemotherapy

Hummel-Siebert-2006 0.92 % A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. Hummel et al. (2006). N Engl J Med . Source: Pearson correlation with 466,765 interactions from GEO Tags: cancer

Kang-Willman-2010 0.90 % Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia. Kang et al. (2010). Blood . Source: Pearson correlation with 549,783 interactions from GEO Tags: transcription factors; lymphoma; cancer

Gobble-Singer-2011 0.89 % Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis. Gobble et al. (2011). Cancer Res . Source: Pearson correlation with 449,507 interactions from GEO Tags: apoptosis; cell line; cultured cells; cancer; transcription factors

Radtke-Downing-2009 0.87 % Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia. Radtke et al. (2009). Proc Natl Acad Sci U S A . Source: Pearson correlation with 377,767 interactions from GEO Tags: transcription factors; nervous system; cancer

Raue-Trappe-2012 0.65 % Transcriptome signature of resistance exercise adaptations: mixed muscle and fiber type specific profiles in young and old adults. Raue et al. (2012). J Appl Physiol . Source: Pearson correlation with 483,849 interactions from GEO

Wang-Maris-2006 0.60 %

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Integrative genomics identifies distinct molecular classes of neuroblastoma and shows that multiple genes are targeted by regional alterations in DNA copy number. Wang et al. (2006). Cancer Res . Source: Pearson correlation with 231,830 interactions from GEO Tags: transcription factors; cancer

Bild-Nevins-2006 B 0.55 % Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Bild et al. (2006). Nature . Note: One of 3 datasets produced from this publication. Source: Pearson correlation with 254,105 interactions from GEO Tags: cultured cells; signal transduction; cancer; epithelial cells; cell line; disease; breast; transcription factors; breast cancer

Arijs-Rutgeerts-2009 0.53 % Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment. Arijs et al. (2009). PLoS One . Source: Pearson correlation with 570,210 interactions from GEO Tags: immune system

Berchtold-Cotman-2008 0.34 % Gene expression changes in the course of normal brain aging are sexually dimorphic. Berchtold et al. (2008). Proc Natl Acad Sci U S A . Source: Pearson correlation with 507,933 interactions from GEO Tags: aging; brain

Perou-Botstein-1999 0.30 % Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Perou et al. (1999). Proc Natl Acad Sci U S A . Source: Pearson correlation with 50,804 interactions from supplementary material Tags: cultured cells; cancer; epithelial cells; signal transduction; breast; stromal cells; transcription factors; breast cancer

Burczynski-Dorner-2006 0.23 % Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells. Burczynski et al. (2006). J Mol Diagn . Source: Pearson correlation with 419,356 interactions from GEO

Noble-Diehl-2008 0.21 % Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis. Noble et al. (2008). Gut . Source: Pearson correlation with 603,016 interactions from GEO

Pathway 15.64 % PATHWAYCOMMONS-CELL_MAP 7.23 % Source: Direct interaction with 598 interactions from Pathway Commons

Wu-Stein-2010 6.96 % A human functional protein interaction network and its application to cancer data analysis. Wu et al. (2010). Genome Biol . Source: 78,448 interactions from supplementary material Tags: transcription factors; cancer

PATHWAYCOMMONS-NCI_NATURE 1.45 % Source: Direct interaction with 10,118 interactions from Pathway Commons

Shared protein domains 5.78 % INTERPRO 3.65 % Source: Pearson correlation with 488,822 interactions from InterPro

PFAM 2.14 % Source: Pearson correlation with 530,357 interactions from Pfam

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Genetic interactions 5.39 % IREF-SMALL-SCALE-STUDIES 5.32 % Source: Direct interaction with 171 interactions from iRefIndex

BIOGRID-SMALL-SCALE-STUDIES 0.07 % Source: Direct interaction with 345 interactions from BioGRID

Co-localization 3.96 % Schadt-Shoemaker-2004 2.81 % A comprehensive transcript index of the human genome generated using microarrays and computational approaches. Schadt et al. (2004). Genome Biol . Note: Predicted transcript array Source: Pearson correlation with 60,454 interactions from GEO

Johnson-Shoemaker-2003 1.15 % Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Johnson et al. (2003). Science . Source: Pearson correlation with 426,934 interactions from GEO Tags: cultured cells; cell line

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Attributes

Attribute Gene

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Genes

SESN3 sestrin 3 [Source:HGNC Symbol;Acc:23060] Functions: 1

Synonyms: ENSG00000149212; ENSP00000278499; ENSP00000376926; ENSP00000407008; ENSP00000439580; ENSP00000441927; 143686; SESN3; NP_653266; NM_144665; MGC29667; SEST3; P58005; SESN3_HUMAN; More at Entrez

SESN2 sestrin 2 [Source:HGNC Symbol;Acc:20746] Functions: 1

Synonyms: ENSG00000130766; ENSP00000253063; 83667; SESN2; NP_113647; NM_031459; DKFZp761M0212; HI95; SEST2; P58004; SESN2_HUMAN; More at Entrez

EI24 etoposide induced 2.4 mRNA [Source:HGNC Symbol;Acc:13276] Functions: 1

103

106 134 140

173

Synonyms: ENSG00000149547; ENSP00000278903; ENSP00000364081; ENSP00000431633; ENSP00000433376; ENSP00000435034; ENSP00000435225; ENSP00000435923; ENSP00000436130; ENSP00000437106; 9538; EI24; NP_001007278; NP_004870; NM_001007277; NM_004879; EPG4; TP53I8; EI24_HUMAN; O14681; More at Entrez

GTSE1 G-2 and S-phase expressed 1 [Source:HGNC Symbol;Acc:13698] Functions: 1 2 3 6 7 9 12 19 22 26 30 33 35

37 38 39 43 51 52 53 54 55 56 57 58

190 191

Synonyms: ENSG00000075218; ENSP00000354634; ENSP00000415430; 51512; GTSE1; NP_057510; NM_016426; B99; GTSE-1; GTSE1_HUMAN; Q9NYZ3; More at Entrez

ZMAT3 zinc finger, matrin-type 3 [Source:HGNC Symbol;Acc:29983]

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Functions: 1

Synonyms: ENSG00000172667; ENSP00000311221; ENSP00000396506; ENSP00000398920; 64393; ZMAT3; NP_071915; NP_689426; NM_022470; NM_152240; FLJ12296; MGC10613; PAG608; WIG-1; WIG1; Q9HA38; ZMAT3_HUMAN; More at Entrez

PERP PERP, TP53 apoptosis effector [Source:HGNC Symbol;Acc:17637] Functions: 1

Synonyms: ENSG00000112378; ENSP00000265603; ENSP00000397157; 64065; PERP; NP_071404; NM_022121; dJ496H19.1; KRTCAP1; PIGPC1; RP3-496H19.1; THW; PERP_HUMAN; Q96FX8; More at Entrez

PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 [Source:HGNC Symbol;Acc:9108] Functions: 1 5 9 10 11 13 14 16 17 18 20 26 27 28 29 30 34

36 46 48 50 62 64 66 67 68 70

73 75 79 84 90

112 114 116 119 120 123 126 128 129 136

143 144 146 150 152 153 155 157 160 163 169

181 187 192 202 208

Synonyms: ENSG00000141682; ENSP00000269518; ENSP00000326119; 5366; PMAIP1; NP_066950; NM_021127; NOXA; APR_HUMAN; Q13794; More at Entrez

CCNG2 cyclin G2 [Source:HGNC Symbol;Acc:1593] Functions: 1 2 3

Synonyms: ENSG00000138764; ENSP00000315743; ENSP00000346379; ENSP00000379002; ENSP00000424665; ENSP00000426085; ENSP00000426476; 901; CCNG2; NP_004345; NM_004354; CCNG2_HUMAN; Q16589;

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More at Entrez

TCOF1 Treacher Collins-Franceschetti syndrome 1 [Source:HGNC Symbol;Acc:11654] Functions: 1

Synonyms: ENSG00000070814; ENSP00000325223; ENSP00000367028; ENSP00000377811; ENSP00000390717; ENSP00000400939; ENSP00000406888; ENSP00000409944; ENSP00000421655; ENSP00000422567; ENSP00000426471; ENSP00000426587; ENSP00000427484; 6949; TCOF1; NP_000347; NP_001008657; NP_001128715; NP_001128716; NP_001128717; NP_001182070; NM_000356; NM_001008656; NM_001008657; NM_001135243; NM_001135244; NM_001135245; NM_001195141; MFD1; treacle; Q13428; TCOF_HUMAN; More at Entrez

CD82 CD82 molecule [Source:HGNC Symbol;Acc:6210] Functions: 1

Synonyms: ENSG00000085117; ENSP00000227155; ENSP00000339686; ENSP00000431767; ENSP00000433036; ENSP00000433151; ENSP00000433788; ENSP00000433804; ENSP00000435661; ENSP00000435682; ENSP00000436403; 3732; CD82; NP_001020015; NP_002222; NM_001024844; NM_002231; 4F9; C33; GR15; KAI1; SAR2; ST6; TSPAN27; CD82_HUMAN; P27701; More at Entrez

PIDD (LRDD) p53-induced death domain protein [Source:HGNC Symbol;Acc:16491] Functions: 1 2 3 6 7 9 12 19 22 26 30 33 35

37 38 39 43 51 52 53 54 55 56 57 58

194

Synonyms: ENSG00000177595; ENSP00000337797; ENSP00000416801; ENSP00000435008; ENSP00000436146; ENSP00000436342; 55367; PIDD; NP_665893; NP_665894; NM_018494; NM_145886; NM_145887; DKFZp434D229; LRDD; MGC16925; PIDD_HUMAN; Q9HB75; More at Entrez

GADD45B growth arrest and DNA-damage-inducible, beta [Source:HGNC Symbol;Acc:4096] Functions: 1

Synonyms: ENSG00000099860; ENSP00000215631; 4616; GADD45B; NP_056490; NM_015675; DKFZP566B133; GADD45BETA; MYD118; GA45B_HUMAN; O75293;

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More at Entrez

APAF1 apoptotic peptidase activating factor 1 [Source:HGNC Symbol;Acc:576] Functions: 1 5 10 11 13 14 16 17 18 20 27 29 31 34

219

Synonyms: ENSG00000120868; ENSP00000334558; ENSP00000341830; ENSP00000349862; ENSP00000353059; ENSP00000448161; ENSP00000448165; ENSP00000448449; ENSP00000448826; ENSP00000449791; ENSP00000450175; 317; APAF1; NP_001151; NP_037361; NP_863651; NP_863658; NP_863659; NM_001160; NM_013229; NM_181861; NM_181868; NM_181869; APAF-1; APAF_HUMAN; O14727; More at Entrez

THBS1 thrombospondin 1 [Source:HGNC Symbol;Acc:11785] Functions: 1 10 11 25 27 29

111 115 117 118 122 123 124 127 132 137

142 147 148 149 154 156 158 167 169

176 183 200 201 202 209

212 216 224 225 226

Synonyms: ENSG00000137801; ENSP00000260356; ENSP00000380720; ENSP00000380721; 7057; THBS1; NP_003237; NM_003246; THBS; THBS-1; TSP; TSP-1; P07996; TSP1_HUMAN; More at Entrez

CCNG1 cyclin G1 [Source:HGNC Symbol;Acc:1592] Functions: 1 8 25

Synonyms: ENSG00000113328; ENSP00000344635; ENSP00000377506; ENSP00000421132; ENSP00000421383; ENSP00000422379; ENSP00000423791; ENSP00000424141; ENSP00000424315; ENSP00000427086; 900; CCNG1; NP_004051; NP_954854; NM_004060; NM_199246; CCNG; CCNG1_HUMAN; P51959; More at Entrez

GADD45G growth arrest and DNA-damage-inducible, gamma [Source:HGNC Symbol;Acc:4097] Functions: 1

110

Synonyms: ENSG00000130222; ENSP00000252506; ENSP00000364924; 10912; GADD45G; NP_006696; NM_006705; CR6; DDIT2; GADD45gamma; GRP17; GA45G_HUMAN; O95257; More at Entrez

CCNE1 cyclin E1 [Source:HGNC Symbol;Acc:1589]

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Functions: 1 4

Synonyms: ENSG00000105173; ENSP00000262643; ENSP00000350625; ENSP00000410179; 898; CCNE1; NP_001229; NM_001238; NM_057182; CCNE; CCNE1_HUMAN; P24864; More at Entrez

POLR1D polymerase (RNA) I polypeptide D, 16kDa [Source:HGNC Symbol;Acc:20422] Functions: 1

83 88 92

109

172

184 186

Synonyms: ENSG00000186184; ENSP00000302478; ENSP00000382603; ENSP00000382604; 51082; POLR1D; NP_001193488; NP_057056; NP_689918; NM_001206559; NM_015972; NM_152705; AC19; MGC9850; RPA16; RPA9; RPAC2; RPC16; RPO1-3; TCS2; Q9Y2S0; RPAC2_HUMAN; More at Entrez

CCNE2 cyclin E2 [Source:HGNC Symbol;Acc:1590] Functions: 1 2 3 4

Synonyms: ENSG00000175305; ENSP00000309181; ENSP00000379437; ENSP00000428988; ENSP00000429089; ENSP00000430060; ENSP00000430875; ENSP00000445726; 9134; CCNE2; NP_477097; NM_004702; NM_057735; NM_057749; CYCE2; CCNE2_HUMAN; O96020; More at Entrez

POLR1C polymerase (RNA) I polypeptide C, 30kDa [Source:HGNC Symbol;Acc:20194] Functions: 1

83 88 92

109

172

184 186

Synonyms: ENSG00000171453; ENSP00000307212; ENSP00000361419; ENSP00000361448; ENSP00000361465; ENSP00000395401; ENSP00000409536; ENSP00000423773; 9533; POLR1C; NP_976035; NM_004875;

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NM_203290; RPA39; RPA40; RPA5; RPAC1; TCS3; O15160; RPAC1_HUMAN; More at Entrez

CCND2 cyclin D2 [Source:HGNC Symbol;Acc:1583] Functions: 1 8 15 25

61 65

108 130

142 147 148

176 185

Synonyms: ENSG00000118971; ENSP00000261254; ENSP00000442807; 894; CCND2; NP_001750; NM_001759; KIAK0002; CCND2_HUMAN; P30279; More at Entrez

CASP9 caspase 9, apoptosis-related cysteine peptidase [Source:HGNC Symbol;Acc:1511] Functions: 1 5 10 11 13 14 16 17 18 20 27 29 31

95 97

111 117 118 125

154 158 170

219

Synonyms: ENSG00000132906; ENSP00000255256; ENSP00000330237; ENSP00000365034; ENSP00000365051; ENSP00000383588; ENSP00000396540; ENSP00000408691; ENSP00000411304; ENSP00000449216; ENSP00000449584; 842; CASP9; NP_001220; NP_127463; NM_001229; NM_032996; APAF-3; APAF3; CASPASE-9c; ICE-LAP6; MCH6; PPP1R56; CASP9_HUMAN; P55211; More at Entrez

UBTF upstream binding transcription factor, RNA polymerase I [Source:HGNC Symbol;Acc:12511] Functions: 1

83 88 92

109

172

184 186

Synonyms: ENSG00000108312; ENSP00000302640; ENSP00000345297; ENSP00000377231; ENSP00000390669; ENSP00000431295; ENSP00000431539; ENSP00000432925; ENSP00000433046; ENSP00000433625; ENSP00000435708; ENSP00000437180; 7343; UBTF; NP_001070151; NP_001070152; NP_055048; NM_001076683; NM_001076684; NM_014233; NR_045058; NOR-90; UBF; UBF-1; UBF1; P17480; UBF1_HUMAN; More at Entrez

RRM2 ribonucleotide reductase M2 [Source:HGNC Symbol;Acc:10452] Functions: 1 4

41 49

Synonyms: ENSG00000171848; ENSP00000302955; ENSP00000353770; ENSP00000417419; ENSP00000419177; 6241; RRM2; NP_001025; NP_001159403; NM_001034; NM_001165931; RR2; RR2M; P31350; RIR2_HUMAN;

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More at Entrez

CCNB2 cyclin B2 [Source:HGNC Symbol;Acc:1580] Functions: 1 2 3 23

Synonyms: ENSG00000157456; ENSP00000288207; ENSP00000453685; 9133; CCNB2; NP_004692; NM_004701; HsT17299; CCNB2_HUMAN; O95067; More at Entrez

TSC2 tuberous sclerosis 2 [Source:HGNC Symbol;Acc:12363] Functions: 1

76 95 97

111 117 118 125 138

154 158 170

201

219 223 224

Synonyms: ENSG00000103197; ENSP00000219476; ENSP00000248099; ENSP00000344383; ENSP00000371978; ENSP00000384468; ENSP00000387937; ENSP00000387983; ENSP00000399232; ENSP00000406980; 7249; TSC2; NP_000539; NP_001070651; NP_001107854; NM_000548; NM_001077183; NM_001114382; NM_021055; NM_021056; TSC4; tuberin; P49815; TSC2_HUMAN; More at Entrez

IGF1 insulin-like growth factor 1 (somatomedin C) [Source:HGNC Symbol;Acc:5464] Functions: 1 6 28

36 39 48 49

77 78 79 81 82 84 95 97 101 103

115 116 139

142 147 148 155 156 164 165 166 167

185 198 199 206 209

217 220 221 225

Synonyms: ENSG00000017427; ENSP00000302665; ENSP00000337612; ENSP00000376637; ENSP00000376638; ENSP00000394999; ENSP00000416811; 3479; IGF1; NP_000609; NP_001104753; NP_001104754; NP_001104755; NM_000618; NM_001111283; NM_001111284; NM_001111285; IGF-I; IGF1A; IGFI; IGF1_HUMAN; P05019; More at Entrez

BID BH3 interacting domain death agonist [Source:HGNC Symbol;Acc:1050] Functions: 1 5 28

36 46 48 64

71 73 74 75 79 84 105

114 116 128 136

144 155 161

192 194 202 208 210

Synonyms: ENSG00000015475; ENSP00000318822; ENSP00000344594; ENSP00000382667; ENSP00000382669; ENSP00000382674; ENSP00000449236; 637; BID; NP_001187; NP_001231496; NP_001231498; NP_001231499; NP_001231501; NP_932070; NP_932071; NM_001196; NM_001244567; NM_001244569; NM_001244570; NM_001244572; NM_197966; NM_197967; FP497; BID_HUMAN; P55957;

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More at Entrez

SFN stratifin [Source:HGNC Symbol;Acc:10773] Functions: 1 5 9 10 11 27 28 29

36 48 69

138

171

207

Synonyms: ENSG00000175793; ENSP00000340989; ENSP00000445361; 2810; SFN; NP_006133; NM_006142; YWHAS; 1433S_HUMAN; P31947; More at Entrez

CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) [Source:HGNC Symbol;Acc:1787] Functions: 1 2 3 4 6 7 8 9 10 11 13 14 16 17 18 20 21 23 24 25 26 27 28 29 30

39 43 45 48 60 61 63 65 68 69

76 82 85 89 91 96 99 100 103 104

106 108 122 126 127 129 131 133 134 135 137 138 139 140

143 145 146 149 153 162 173

178 181 183 188 195 204 206 207

212 217 218 226

Synonyms: ENSG00000147889; ENSP00000307101; ENSP00000355153; ENSP00000369496; ENSP00000394932; ENSP00000418915; ENSP00000432664; 1029; CDKN2A; NP_000068; NP_001182061; NP_478102; NP_478104; NM_000077; NM_001195132; NM_058195; NM_058196; NM_058197; ARF; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; P14ARF; P16; P16-INK4A; P16INK4; P16INK4A; P19ARF; TP16; CD2A1_HUMAN; CD2A2_HUMAN; P42771; Q8N726; More at Entrez

TP73 tumor protein p73 [Source:HGNC Symbol;Acc:12003] Functions: 1 2 3 4 5 6 7 9 12 19 22 25 26 30 33 35

37 38 40 42 59 61 65 69

71 72 74 76 87 94 102

107 108 110 121 138

141 143 151 157 171

188

214 215 222

Synonyms: ENSG00000078900; ENSP00000340740; ENSP00000346423; ENSP00000350366; ENSP00000367529; ENSP00000367534; ENSP00000367537; ENSP00000367539; ENSP00000367545; 7161; TP73; NP_001119712; NP_001119713; NP_001119714; NP_001191113; NP_001191114; NP_001191115; NP_001191116; NP_001191117; NP_001191118; NP_001191119; NP_001191120; NP_001191121; NP_005418; NM_001126240; NM_001126241; NM_001126242; NM_001204184; NM_001204185; NM_001204186; NM_001204187; NM_001204188; NM_001204189; NM_001204190; NM_001204191; NM_001204192; NM_005427; O15350; P73_HUMAN; More at Entrez

CDK6 cyclin-dependent kinase 6 [Source:HGNC Symbol;Acc:1777] Functions: 1 4 15 21 24 32

45 60 63

78 81 101

113 122 137

143

183 195 199 200 209

212 225

Synonyms: ENSG00000105810; ENSP00000265734; ENSP00000397087; 1021; CDK6; NP_001138778;

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NP_001250; NM_001145306; NM_001259; PLSTIRE; CDK6_HUMAN; Q00534; More at Entrez

ATR ataxia telangiectasia and Rad3 related [Source:HGNC Symbol;Acc:882] Functions: 1 2 3 9 12 19 26 30

40 42 45 49 59 60 63

72 87 93 94 102

107 110 113 121

141 143 146 153 167

181

Synonyms: ENSG00000175054; ENSP00000343741; ENSP00000372581; ENSP00000421870; ENSP00000422553; ENSP00000424355; ENSP00000424754; ENSP00000425897; ENSP00000426595; 545; ATR; NP_001175; NM_001184; MEC1; SCKL; SCKL1; ATR_HUMAN; Q13535; More at Entrez

CHEK1 CHK1 checkpoint homolog (S. pombe) [Source:HGNC Symbol;Acc:1925] Functions: 1 2 3 6 12 19

40 42 45 49 59 60 62 63

72 80 87 94 98

107 108 110 113

141 143 153 156 164 165 166

180 182 193 198

211 213 220 221 227

Synonyms: ENSG00000149554; ENSP00000278916; ENSP00000388648; ENSP00000391090; ENSP00000412504; ENSP00000431525; ENSP00000431815; ENSP00000432470; ENSP00000432890; ENSP00000433103; ENSP00000434141; ENSP00000434646; ENSP00000435371; ENSP00000442317; 1111; CHEK1; NP_001107593; NP_001107594; NP_001231775; NP_001265; NM_001114121; NM_001114122; NM_001244846; NM_001274; NR_045204; NR_045205; CHK1; CHK1_HUMAN; O14757; More at Entrez

CYCS cytochrome c, somatic [Source:HGNC Symbol;Acc:19986] Functions: 1 5 10 11 13 14 16 17 18 20 27 29 31

85 89 104

126 129 131 136

144 145

Synonyms: ENSG00000172115; ENSP00000307786; ENSP00000386270; ENSP00000387279; ENSP00000416479; 54205; CYCS; NP_061820; NM_018947; CYC; THC4; CYC_HUMAN; P99999; More at Entrez

SIAH1 (SIAH1A) seven in absentia homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:10857] Functions: 1 34

50 67 70

71 74

112 119 120

150 152

196

Synonyms: ENSG00000196470; ENSP00000349156; ENSP00000369343; ENSP00000378214; 6477; SIAH1; NP_001006611; NP_003022; NM_001006610; NM_003031; hSIAH1; SIAH1A; Q8IUQ4; SIAH1_HUMAN;

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More at Entrez

FAS Fas (TNF receptor superfamily, member 6) [Source:HGNC Symbol;Acc:11920] Functions: 1 10 11 13 14 16 17 18 20 27 29

40 42 46 61 62

80 98 105

115

163 169

Synonyms: ENSG00000026103; ENSP00000345601; ENSP00000347426; ENSP00000347979; ENSP00000349896; ENSP00000360942; ENSP00000420975; ENSP00000422453; ENSP00000423755; ENSP00000424113; ENSP00000425159; ENSP00000441676; 355; FAS; NP_000034; NP_690610; NP_690611; NM_000043; NM_152871; NM_152872; NM_152873; NM_152874; NM_152875; NM_152876; NM_152877; NR_028033; NR_028034; NR_028035; NR_028036; ALPS1A; APO-1; CD95; FAS1; FASTM; TNFRSF6; P25445; TNR6_HUMAN; More at Entrez

BAX BCL2-associated X protein [Source:HGNC Symbol;Acc:959] Functions: 1 5 10 11 13 14 16 17 18 20 27 28 29 31 34

36 46 48 50 64 66 67 68 70

71 73 74 75 85 89 104 105

112 114 115 119 120 126 128 129 131 136

144 145 151 152 155 159 164

178 187 197 202 203

Synonyms: ENSG00000087088; ENSP00000263262; ENSP00000293288; ENSP00000346461; ENSP00000348871; ENSP00000375744; ENSP00000389971; ENSP00000426184; ENSP00000426328; ENSP00000441413; 581; BAX; NP_004315; NP_620116; NP_620118; NP_620119; NM_004324; NM_138761; NM_138762; NM_138763; NM_138764; NR_027882; BCL2L4; BAX_HUMAN; Q07812; More at Entrez

PTEN phosphatase and tensin homolog [Source:HGNC Symbol;Acc:9588] Functions: 1 4 6 7 8 25 33

39 69

76 77 95 96 97 99 100

111 112 116 117 118 119 122 125 127 133 135 137 138

149 150 154 155 156 158 162 164 165 166 167 168 170 175

183 196 197 201 202

212 218 220 221 223 224 226

Synonyms: ENSG00000171862; ENSP00000361021; 5728; PTEN; NP_000305; NM_000314; BZS; DEC; GLM2; MHAM; MMAC1; PTEN1; P60484; PTEN_HUMAN; More at Entrez

CCNB1 cyclin B1 [Source:HGNC Symbol;Acc:1579] Functions: 1 2 3 4 6 22 23

61 65

112 116 119 126 129 133 135

150 155 156 162 164 168 175

196 198

211 220 221

Synonyms: ENSG00000134057; ENSP00000256442; ENSP00000423387; ENSP00000424588; ENSP00000425103; ENSP00000426092; ENSP00000426230; 891; CCNB1; NP_114172; NM_031966; CCNB; CCNB1_HUMAN; P14635;

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More at Entrez

CCND1 cyclin D1 [Source:HGNC Symbol;Acc:1582] Functions: 1 2 3 4 6 7 8 12 15 19 21 22 24 25 33 35

37 38 42 44 47 61 65

72 77

107 130 132

141 142 147 148

176 185

Synonyms: ENSG00000110092; ENSP00000227507; ENSP00000437558; ENSP00000438482; ENSP00000441863; ENSP00000445014; 595; CCND1; NP_444284; NM_053056; BCL1; D11S287E; PRAD1; U21B31; CCND1_HUMAN; P24385; More at Entrez

CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) [Source:HGNC Symbol;Acc:1784] Functions: 1 2 3 4 5 6 7 8 9 12 15 19 21 22 23 24 25 26 30 32 33 35

37 38 39 40 42 43 44 45 47 51 52 53 54 55 56 57 58 59 60 62 63

72 78 81 82 86 93 96 99 100 101 102 103

106 113 123 124 134 139 140

173

219

Synonyms: ENSG00000124762; ENSP00000244741; ENSP00000362815; ENSP00000384849; ENSP00000409259; 1026; CDKN1A; NP_000380; NP_001207706; NP_001207707; NP_510867; NM_000389; NM_001220777; NM_001220778; NM_078467; NR_037150; CAP20; CDKN1; MDA-6; p21CIP1; p21Cip1/Waf1; SDI1; WAF1; CDN1A_HUMAN; P38936; More at Entrez

CASP8 caspase 8, apoptosis-related cysteine peptidase [Source:HGNC Symbol;Acc:1509] Functions: 1 5 10 11 13 14 16 17 18 20 27 29 34

40 42 46 62 64 68

73 75 80 98 105

112 119 126 129 136

144

177 189

Synonyms: ENSG00000064012; ENSP00000264274; ENSP00000264275; ENSP00000325722; ENSP00000351273; ENSP00000376087; ENSP00000376088; ENSP00000376089; ENSP00000376091; ENSP00000376094; ENSP00000388306; ENSP00000390346; ENSP00000390641; ENSP00000391709; ENSP00000394434; ENSP00000396869; ENSP00000397528; ENSP00000407378; ENSP00000412523; 841; CASP8; NP_001073593; NP_001073594; NP_001219; NP_203519; NP_203520; NP_203522; NM_001080124; NM_001080125; NM_001228; NM_033355; NM_033356; NM_033357; NM_033358; ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5; CASP8_HUMAN; Q14790; More at Entrez

CASP3 caspase 3, apoptosis-related cysteine peptidase [Source:HGNC Symbol;Acc:1504] Functions: 1 5 10 11 13 14 16 17 18 20 27 29 31

85 89 104 105

125 126 129 131

145 159

177

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Synonyms: ENSG00000164305; ENSP00000311032; ENSP00000377210; ENSP00000377213; ENSP00000390792; ENSP00000407142; ENSP00000428372; ENSP00000428929; 836; CASP3; NP_004337; NP_116786; NM_004346; NM_032991; apopain; CPP32; CPP32B; SCA-1; Yama; CASP3_HUMAN; P42574; More at Entrez

CDK2 cyclin-dependent kinase 2 [Source:HGNC Symbol;Acc:1771] Functions: 1 2 3 4 6 7 9 12 15 19 21 22 23 24 26 30 32 33 35

37 38 39 43 44 47 49 51 52 53 54 55 56 57 58

112 113 119 133 135 139

150 162 168 175

180 190 191 193 196

213 227

Synonyms: ENSG00000123374; ENSP00000243067; ENSP00000266970; ENSP00000393605; ENSP00000450983; ENSP00000452138; ENSP00000452514; 1017; CDK2; NP_001789; NP_439892; NM_001798; NM_052827; p33(CDK2); CDK2_HUMAN; P24941; More at Entrez

CDK4 cyclin-dependent kinase 4 [Source:HGNC Symbol;Acc:1773] Functions: 1 4 15 21 24 32

44 47

78 81 101

108 113 132

Synonyms: ENSG00000135446; ENSP00000257904; ENSP00000316889; ENSP00000439076; ENSP00000446763; ENSP00000447005; ENSP00000447274; ENSP00000447779; ENSP00000448098; ENSP00000448885; ENSP00000448963; ENSP00000449179; ENSP00000449391; ENSP00000449725; 1019; CDK4; NP_000066; NM_000075; NM_052984; CMM3; PSK-J3; CDK4_HUMAN; P11802; More at Entrez

CDK1 cyclin-dependent kinase 1 [Source:HGNC Symbol;Acc:1722] Functions: 1 2 3 4 23 25 32

41 49

110 111 112 113 115 117 118 119 125 133 135 139

150 154 158 159 162 168 170 175

176 180 196

213 227

Synonyms: ENSG00000170312; ENSP00000325970; ENSP00000362915; ENSP00000378699; ENSP00000397973; ENSP00000430665; 983; CDK1; NP_001163877; NP_001163878; NP_001777; NP_203698; NM_001130829; NM_001170406; NM_001170407; NM_001786; NM_033379; CDC28A; P34CDC2; CDK1_HUMAN; P06493; More at Entrez

TP53 tumor protein p53 [Source:HGNC Symbol;Acc:11998] Functions: 1 2 3 4 5 6 7 9 10 11 12 13 14 16 17 18 19 20 22 26 27 29 30 31 33 35

37 38 39 40 42 43 45 48 51 52 53 54 55 56 57 58 59 60 61 62 63 65

71 72 74 78 81 82 86 87 90 93 94 102 103

106 107 108 110 116 121 123 124 132 134 139 140

141 142 147 148 151 155 157 160 163 169 171 173

178 185 188 203 204

211 214 215 222

Synonyms: ENSG00000141510; ENSP00000269305; ENSP00000352610; ENSP00000379735; ENSP00000391127;

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ENSP00000391478; ENSP00000394195; ENSP00000398846; ENSP00000402130; ENSP00000410739; ENSP00000423862; ENSP00000424104; ENSP00000425104; ENSP00000426252; ENSP00000437792; 7157; TP53; NP_000537; NP_001119584; NP_001119585; NP_001119586; NP_001119587; NP_001119588; NP_001119589; NP_001119590; NM_000546; NM_001126112; NM_001126113; NM_001126114; NM_001126115; NM_001126116; NM_001126117; NM_001126118; LFS1; P53; TRP53; P04637; P53_HUMAN; More at Entrez

CCND3 cyclin D3 [Source:HGNC Symbol;Acc:1585] Functions: 8 15 25

61 65

130

142 147 148

176 185

Synonyms: ENSG00000112576; ENSP00000362078; ENSP00000362079; ENSP00000362082; ENSP00000397545; ENSP00000401595; ENSP00000420991; ENSP00000421511; ENSP00000423242; ENSP00000425334; ENSP00000425830; ENSP00000425986; ENSP00000426212; 896; CCND3; NP_001129489; NP_001129597; NP_001129598; NP_001751; NM_001136017; NM_001136125; NM_001136126; NM_001760; CCND3_HUMAN; P30281; More at Entrez

CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) [Source:HGNC Symbol;Acc:1785] Functions: 2 3 4 6 7 8 9 10 11 12 13 14 16 17 18 19 20 21 22 24 25 26 27 29 30 32 33 35

37 38 39 43 44 47 51 52 53 54 55 56 57 58 69

76 95 96 97 99 100 103

106 111 113 117 118 125 134 140

154 158 170 173

219

Synonyms: ENSG00000111276; ENSP00000228872; ENSP00000379629; ENSP00000407597; ENSP00000442344; 1027; CDKN1B; NP_004055; NM_004064; CDKN4; MEN1B; MEN4; P27KIP1; CDN1B_HUMAN; P46527; More at Entrez

BCL2 B-cell CLL/lymphoma 2 [Source:HGNC Symbol;Acc:990] Functions: 5 28 34

36 42 46 48 64 66 67

71 72 73 74 75 90 103

115 132 136 140

144 151 160 173

187 189 197 205

Synonyms: ENSG00000171791; ENSP00000329623; ENSP00000381185; ENSP00000404214; 596; BCL2; NP_000624; NP_000648; NM_000633; NM_000657; Bcl-2; PPP1R50; BCL2_HUMAN; P10415; More at Entrez

BCL2L1 BCL2-like 1 [Source:HGNC Symbol;Acc:992] Functions: 2 3 5 6 7 22 23 28 34

36 48 50 61 64 65 66 67 70

73 75 79 84 90 91

115 136

144 156 160 161

182 187 189 197 198 205 210

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Synonyms: ENSG00000171552; ENSP00000302564; ENSP00000365223; ENSP00000365230; ENSP00000389688; ENSP00000390760; ENSP00000395545; ENSP00000401173; ENSP00000405563; ENSP00000406203; ENSP00000411252; 598; BCL2L1; NP_001182; NP_612815; NM_001191; NM_138578; Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52; B2CL1_HUMAN; Q07817; More at Entrez

CCNA2 cyclin A2 [Source:HGNC Symbol;Acc:1578] Functions: 2 3 6 7 12 19 22 23

82 91

139

182

Synonyms: ENSG00000145386; ENSP00000274026; 890; CCNA2; NP_001228; NM_001237; CCNA; CCNA2_HUMAN; P20248; More at Entrez

SESN1 sestrin 1 [Source:HGNC Symbol;Acc:21595] Functions:

Synonyms: ENSG00000080546; ENSP00000306734; ENSP00000349061; ENSP00000393762; 27244; SESN1; NP_001186862; NP_001186863; NP_055269; NM_001199933; NM_001199934; NM_014454; PA26; SEST1; Q9Y6P5; SESN1_HUMAN; More at Entrez

PCNA proliferating cell nuclear antigen [Source:HGNC Symbol;Acc:8729] Functions: 4

41 44 47 49

95 97

110

167 174

179

211

Synonyms: ENSG00000132646; ENSP00000368438; ENSP00000368458; 5111; PCNA; NP_002583; NP_872590; NM_002592; NM_182649; P12004; PCNA_HUMAN; More at Entrez

CDC25C cell division cycle 25 homolog C (S. pombe) [Source:HGNC Symbol;Acc:1727] Functions: 2 3 6 8 21 23 24 25

49 61 65

164 165 166

197

220 221

Synonyms: ENSG00000158402; ENSP00000321656; ENSP00000345205; ENSP00000348898; ENSP00000349821; ENSP00000392631; ENSP00000423525; ENSP00000424795; ENSP00000425470; ENSP00000427105;

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ENSP00000427251; ENSP00000443196; 995; CDC25C; NP_001781; NP_073720; NM_001790; NM_022809; PPP1R60; MPIP3_HUMAN; P30307; More at Entrez

PTCH1 patched 1 [Source:HGNC Symbol;Acc:9585] Functions:

103

106

161

199 210

Synonyms: ENSG00000185920; ENSP00000332353; ENSP00000364420; ENSP00000364423; ENSP00000364424; ENSP00000364433; ENSP00000364439; ENSP00000389744; ENSP00000396135; ENSP00000399981; ENSP00000410287; ENSP00000414823; ENSP00000439213; ENSP00000447008; ENSP00000447242; ENSP00000447797; ENSP00000447878; ENSP00000448843; ENSP00000449078; ENSP00000449745; ENSP00000450047; ENSP00000450131; 5727; PTCH1; NP_000255; NP_001077071; NP_001077072; NP_001077073; NP_001077074; NP_001077075; NP_001077076; NM_000264; NM_001083602; NM_001083603; NM_001083604; NM_001083605; NM_001083606; NM_001083607; BCNS; HPE7; NBCCS; PTC1; PTCH; PTCH11; PTC1_HUMAN; Q13635; More at Entrez

RRM2B ribonucleotide reductase M2 B (TP53 inducible) [Source:HGNC Symbol;Acc:17296] Functions:

Synonyms: ENSG00000048392; ENSP00000251810; ENSP00000379248; ENSP00000427830; ENSP00000428115; ENSP00000429140; ENSP00000429578; ENSP00000430641; ENSP00000444347; 50484; RRM2B; NP_001165948; NP_001165949; NP_056528; NM_001172477; NM_001172478; NM_015713; MTDPS8A; MTDPS8B; P53R2; Q7LG56; RIR2B_HUMAN; More at Entrez

CASP2 caspase 2, apoptosis-related cysteine peptidase [Source:HGNC Symbol;Acc:1503] Functions: 2 3 6 7 9 12 19 22 26 30 33 34 35

37 38 39 40 42 43 51 52 53 54 55 56 57 58 62

80 98 105

125

177 197

Synonyms: ENSG00000106144; ENSP00000312664; ENSP00000340030; ENSP00000376654; ENSP00000376656; 835; CASP2; NP_001215; NP_116764; NP_116765; NM_001224; NM_032982; NM_032983; CASP-2; ICH1; NEDD-2; NEDD2; PPP1R57; CASP2_HUMAN; P42575; More at Entrez

MCM2 minichromosome maintenance complex component 2 [Source:HGNC Symbol;Acc:6944] Functions: 2 3 4

44 47 49

108

174

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179

211 Synonyms: ENSG00000073111; ENSP00000265056; ENSP00000417800; ENSP00000418930; ENSP00000419802; ENSP00000420007; ENSP00000420528; ENSP00000439089; ENSP00000445715; 4171; MCM2; NP_004517; NM_004526; BM28; cdc19; CDCL1; D3S3194; KIAA0030; MITOTIN; MCM2_HUMAN; P49736; More at Entrez

CCNB3 cyclin B3 [Source:HGNC Symbol;Acc:18709] Functions:

Synonyms: ENSG00000147082; ENSP00000276014; ENSP00000338682; ENSP00000365206; ENSP00000365210; ENSP00000379790; ENSP00000431645; 85417; CCNB3; NP_149020; NP_391990; NM_033031; NM_033670; NM_033671; CCNB3_HUMAN; Q8WWL7; More at Entrez

CDC45 cell division cycle 45 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:1739] Functions: 2 3 4 6 7 12 23

41 44 47 49

174

179

Synonyms: ENSG00000093009; ENSP00000263201; ENSP00000384978; ENSP00000385240; ENSP00000388280; ENSP00000397434; ENSP00000405726; ENSP00000413138; 8318; CDC45; NP_001171481; NP_001171482; NP_003495; NM_001178010; NM_001178011; NM_003504; CDC45L; CDC45L2; PORC-PI-1; CDC45_HUMAN; O75419; More at Entrez

CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) [Source:HGNC Symbol;Acc:1786] Functions: 8 21 24 25

76 96 99 100

200 209

216 225

Synonyms: ENSG00000129757; ENSP00000321019; ENSP00000370101; ENSP00000411257; ENSP00000411552; ENSP00000413720; 1028; CDKN1C; NP_000067; NP_001116102; NP_001116103; NM_000076; NM_001122630; NM_001122631; BWCR; BWS; CDN1C_HUMAN; P49918; More at Entrez

WEE1 WEE1 homolog (S. pombe) [Source:HGNC Symbol;Acc:12761] Functions: 2 3 4 23

44 47

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Synonyms: ENSG00000166483; ENSP00000299613; ENSP00000402084; ENSP00000432284; ENSP00000434148; ENSP00000434446; ENSP00000435945; 7465; WEE1; NP_001137448; NP_003381; NM_001143976; NM_003390; WEE1A; WEE1hu; P30291; WEE1_HUMAN; More at Entrez

CCNA1 cyclin A1 [Source:HGNC Symbol;Acc:1577] Functions: 4 23

Synonyms: ENSG00000133101; ENSP00000255465; ENSP00000396479; ENSP00000400666; ENSP00000409873; 8900; CCNA1; NP_001104515; NP_001104516; NP_001104517; NP_003905; NM_001111045; NM_001111046; NM_001111047; NM_003914; CCNA1_HUMAN; P78396; More at Entrez

GADD45A growth arrest and DNA-damage-inducible, alpha [Source:HGNC Symbol;Acc:4095] Functions: 8 9 25

40 42 59 62

72 80 86 93 98 102

110 123 124

Synonyms: ENSG00000116717; ENSP00000360024; ENSP00000360025; 1647; GADD45A; NP_001186670; NP_001186671; NP_001915; NM_001199741; NM_001199742; NM_001924; DDIT1; GADD45; GA45A_HUMAN; P24522; More at Entrez

BAG1 BCL2-associated athanogene [Source:HGNC Symbol;Acc:937] Functions:

Synonyms: ENSG00000107262; ENSP00000369022; ENSP00000369026; ENSP00000369029; ENSP00000417576; ENSP00000419092; ENSP00000420514; 573; BAG1; NP_001165886; NP_004314; NM_001172415; NM_004323; RAP46; BAG1_HUMAN; Q99933; More at Entrez

TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa [Source:HGNC Symbol;Acc:11532] Functions:

83 88 92

109

172

184 186

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Synonyms: ENSG00000143498; ENSP00000327072; ENSP00000339976; ENSP00000355856; ENSP00000375754; ENSP00000375755; ENSP00000390405; ENSP00000437725; 9015; TAF1A; NP_001188465; NP_005672; NP_647603; NM_001201536; NM_005681; NM_139352; MGC:17061; RAFI48; TAFI48; Q15573; TAF1A_HUMAN; More at Entrez

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Functions

Function FDR Coverage 1 query genes n/a 48 / 48 2 cell cycle checkpoint 2.67E-23 23 / 235 3 regulation of cell cycle arrest 9.12E-23 23 / 255 4 G1/S transition of mitotic cell cycle 7.44E-22 20 / 169 5 induction of apoptosis by intracellular signals 5.16E-17 14 / 79 6 regulation of mitotic cell cycle 2.94E-15 18 / 260 7 regulation of interphase of mitotic cell cycle 5.29E-14 14 / 130 8 regulation of cyclin-dependent protein kinase activity 1.9E-13 11 / 57 9 signal transduction in response to DNA damage 1.2E-12 13 / 128 10 regulation of cysteine-type endopeptidase activity involved in apoptotic process 1.2E-12 13 / 128 11 regulation of cysteine-type endopeptidase activity 1.47E-12 13 / 131 12 DNA integrity checkpoint 1.48E-12 13 / 132 13 activation of cysteine-type endopeptidase activity 1.61E-12 11 / 72 14 activation of cysteine-type endopeptidase activity involved in apoptotic process 1.61E-12 11 / 72 15 cyclin-dependent protein kinase holoenzyme complex 5.13E-12 7 / 12 16 positive regulation of cysteine-type endopeptidase activity 7.77E-12 11 / 84 17 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 7.77E-12 11 / 84 18 positive regulation of endopeptidase activity 1.09E-11 11 / 87 19 DNA damage checkpoint 1.85E-11 12 / 126 20 positive regulation of peptidase activity 1.85E-11 11 / 92 21 G1 phase of mitotic cell cycle 2.88E-11 9 / 44 22 mitotic cell cycle checkpoint 2.89E-11 12 / 132 23 G2/M transition of mitotic cell cycle 3.31E-11 12 / 134 24 G1 phase 4.78E-11 9 / 47 25 regulation of protein serine/threonine kinase activity 1.23E-10 14 / 249 26 DNA damage response, signal transduction by p53 class mediator 1.26E-10 11 / 112 27 regulation of endopeptidase activity 1.26E-10 13 / 198 28 apoptotic mitochondrial changes 1.81E-10 8 / 34 29 regulation of peptidase activity 1.83E-10 13 / 205 30 signal transduction by p53 class mediator 1.83E-10 11 / 117 31 activation of cysteine-type endopeptidase activity involved in apoptotic process by 1.99E-10 6 / 10 cytochrome c 32 cyclin-dependent protein kinase activity 4.22E-10 6 / 11 33 regulation of G1/S transition of mitotic cell cycle 6.12E-10 10 / 94 34 apoptotic signaling pathway 7.64E-10 8 / 41 35 mitotic cell cycle G1/S transition DNA damage checkpoint 2.43E-9 9 / 74 36 release of cytochrome c from mitochondria 2.93E-9 7 / 28 37 mitotic cell cycle G1/S transition checkpoint 5.96E-9 9 / 82 38 G1/S transition checkpoint 8.08E-9 9 / 85 39 positive regulation of cell cycle process 1.27E-8 10 / 129 40 cellular response to abiotic stimulus 1.75E-8 9 / 93 41 regulation of transcription involved in G1/S phase of mitotic cell cycle 2.68E-8 6 / 20 42 response to abiotic stimulus 1E-7 12 / 278 43 positive regulation of cell cycle arrest 1.48E-7 8 / 79 44 S phase of mitotic cell cycle 2.86E-7 9 / 128 45 cellular senescence 2.91E-7 6 / 29 46 activation of pro-apoptotic gene products 4.21E-7 6 / 31 47 S phase 4.21E-7 9 / 135

第27页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Function FDR Coverage 48 mitochondrion organization 4.21E-7 9 / 135 49 DNA replication 4.85E-7 10 / 191 50 intrinsic apoptotic signaling pathway 7.65E-7 5 / 16 51 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle 1.28E-6 7 / 67 arrest 52 signal transduction involved in mitotic cell cycle G1/S checkpoint 1.28E-6 7 / 67 53 signal transduction involved in mitotic cell cycle checkpoint 1.28E-6 7 / 67 54 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint 1.28E-6 7 / 67 55 signal transduction involved in G1/S transition checkpoint 1.34E-6 7 / 68 56 signal transduction involved in DNA integrity checkpoint 1.34E-6 7 / 68 57 signal transduction involved in DNA damage checkpoint 1.34E-6 7 / 68 58 signal transduction involved in cell cycle checkpoint 1.47E-6 7 / 69 59 cellular response to radiation 2.73E-6 6 / 43 60 cell aging 4.67E-6 6 / 47 61 kinase binding 5.36E-6 10 / 251 62 cellular response to external stimulus 8.79E-6 8 / 138 63 aging 1.46E-5 6 / 57 64 mitochondrial outer membrane 2.18E-5 6 / 61 65 protein kinase binding 2.38E-5 9 / 222 66 regulation of mitochondrial membrane potential 2.88E-5 4 / 13 67 regulation of apoptotic signaling pathway 3.45E-5 5 / 34 68 cellular component disassembly involved in apoptosis 3.79E-5 6 / 68 69 negative regulation of kinase activity 3.79E-5 7 / 113 70 regulation of intrinsic apoptotic signaling pathway 3.79E-5 4 / 14 71 neuron apoptosis 3.79E-5 6 / 68 72 response to radiation 3.99E-5 8 / 171 73 organelle outer membrane 4.78E-5 6 / 71 74 neuron death 5.5E-5 6 / 73 75 outer membrane 5.5E-5 6 / 73 76 negative regulation of transferase activity 5.65E-5 7 / 121 77 positive regulation of cell cycle 6.3E-5 6 / 75 78 regulation of fibroblast proliferation 7.81E-5 5 / 41 79 regulation of release of cytochrome c from mitochondria 7.9E-5 4 / 17 80 cellular response to mechanical stimulus 8.51E-5 5 / 42 81 fibroblast proliferation 8.51E-5 5 / 42 82 Ras protein signal transduction 1.1E-4 7 / 135 83 transcription elongation from RNA polymerase I promoter 1.22E-4 4 / 19 84 regulation of mitochondrion organization 1.76E-4 4 / 21 85 DNA fragmentation involved in apoptotic nuclear change 1.76E-4 4 / 21 86 positive regulation of reactive oxygen species metabolic process 1.76E-4 4 / 21 87 cellular response to UV 1.76E-4 4 / 21 88 termination of RNA polymerase I transcription 1.76E-4 4 / 21 89 DNA catabolic process, endonucleolytic 2.1E-4 4 / 22 90 mitochondrial membrane organization 2.1E-4 4 / 22 91 regulation of G2/M transition of mitotic cell cycle 2.45E-4 4 / 23 92 transcription initiation from RNA polymerase I promoter 2.45E-4 4 / 23 93 cellular response to ionizing radiation 2.45E-4 4 / 23 94 cellular response to light stimulus 2.9E-4 4 / 24 95 phosphatidylinositol-mediated signaling 3.1E-4 6 / 102 96 negative regulation of phosphorylation 3.1E-4 5 / 56 97 inositol lipid-mediated signaling 3.1E-4 6 / 102

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Function FDR Coverage 98 response to mechanical stimulus 3.32E-4 5 / 57 99 negative regulation of phosphorus metabolic process 3.55E-4 5 / 58 100 negative regulation of phosphate metabolic process 3.55E-4 5 / 58 101 positive regulation of fibroblast proliferation 3.78E-4 4 / 26 102 response to ionizing radiation 4.12E-4 5 / 60 103 regulation of growth 4.23E-4 8 / 245 104 apoptotic nuclear change 4.3E-4 4 / 27 105 induction of apoptosis by extracellular signals 4.69E-4 6 / 111 106 negative regulation of growth 5.71E-4 6 / 115 107 response to UV 5.86E-4 5 / 65 108 chromatin 6.9E-4 7 / 185 109 transcription from RNA polymerase I promoter 7.27E-4 4 / 31 110 DNA repair 8.58E-4 8 / 272 111 fibroblast growth factor receptor signaling pathway 1.06E-3 6 / 129 112 proteolysis involved in cellular protein catabolic process 1.12E-3 8 / 283 113 protein serine/threonine kinase activity 1.12E-3 8 / 283 114 positive regulation of protein oligomerization 1.14E-3 3 / 11 115 anti-apoptosis 1.15E-3 7 / 202 116 positive regulation of organelle organization 1.16E-3 6 / 132 117 response to fibroblast growth factor stimulus 1.34E-3 6 / 136 118 cellular response to fibroblast growth factor stimulus 1.34E-3 6 / 136 119 cellular protein catabolic process 1.34E-3 8 / 292 120 positive regulation of intrinsic apoptotic signaling pathway 1.43E-3 3 / 12 121 response to gamma radiation 1.43E-3 3 / 12 122 regulation of cell-matrix adhesion 1.49E-3 4 / 38 123 reactive oxygen species metabolic process 1.51E-3 5 / 81 124 regulation of reactive oxygen species metabolic process 1.63E-3 4 / 39 125 nerve growth factor receptor signaling pathway 1.64E-3 7 / 216 126 cellular component disassembly at cellular level 1.68E-3 7 / 217 127 negative regulation of cell-matrix adhesion 1.76E-3 3 / 13 128 regulation of protein oligomerization 1.76E-3 3 / 13 129 cellular component disassembly 1.79E-3 7 / 220 130 positive regulation of cyclin-dependent protein kinase activity 2.19E-3 3 / 14 131 nucleic acid phosphodiester bond hydrolysis 2.52E-3 4 / 44 132 response to drug 2.6E-3 5 / 92 133 regulation of ubiquitin-protein ligase activity 2.6E-3 5 / 92 134 negative regulation of cell growth 2.87E-3 5 / 94 135 regulation of ligase activity 3E-3 5 / 95 136 mitochondrial membrane 3.98E-3 7 / 251 137 regulation of cell-substrate adhesion 4.35E-3 4 / 51 138 negative regulation of protein kinase activity 4.76E-3 5 / 105 139 small GTPase mediated signal transduction 5.37E-3 7 / 264 140 regulation of cell growth 6.11E-3 6 / 183 141 response to light stimulus 6.34E-3 5 / 112 142 positive regulation of phosphorylation 6.36E-3 6 / 185 143 regulation of cellular response to stress 6.36E-3 6 / 185 144 mitochondrial envelope 6.41E-3 7 / 273 145 DNA catabolic process 6.85E-3 4 / 58 146 regulation of DNA damage response, signal transduction by p53 class mediator 7.01E-3 3 / 21 147 positive regulation of phosphorus metabolic process 7.55E-3 6 / 192

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Function FDR Coverage 148 positive regulation of phosphate metabolic process 7.55E-3 6 / 192 149 negative regulation of cell-substrate adhesion 7.93E-3 3 / 22 150 proteasomal protein catabolic process 8.55E-3 6 / 197 151 regulation of neuron apoptosis 8.55E-3 4 / 62 152 positive regulation of apoptotic signaling pathway 8.92E-3 3 / 23 153 regulation of response to DNA damage stimulus 9.56E-3 4 / 64 154 cellular response to growth factor stimulus 1.01E-2 6 / 204 155 positive regulation of cellular component organization 1.01E-2 7 / 297 156 negative regulation of cellular component organization 1.11E-2 6 / 208 157 signal transduction by p53 class mediator resulting in induction of apoptosis 1.12E-2 3 / 25 158 response to growth factor stimulus 1.22E-2 6 / 212 159 nucleus organization 1.24E-2 3 / 26 160 mitochondrial transport 1.3E-2 4 / 70 161 establishment of protein localization in membrane 1.38E-2 3 / 27 162 regulation of protein ubiquitination 1.59E-2 5 / 140 163 cellular response to oxygen levels 1.69E-2 3 / 29 164 organelle fission 1.79E-2 6 / 229 165 regulation of mitosis 1.81E-2 4 / 77 166 regulation of nuclear division 1.81E-2 4 / 77 167 protein complex binding 1.87E-2 5 / 146 168 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 1.87E-2 4 / 78 169 response to oxygen levels 1.87E-2 4 / 78 170 epidermal growth factor receptor signaling pathway 1.96E-2 5 / 148 171 DNA damage response, signal transduction resulting in induction of apoptosis 1.97E-2 3 / 31 172 transcription termination, DNA-dependent 2.03E-2 4 / 80 173 cell growth 2.1E-2 6 / 238 174 DNA strand elongation involved in DNA replication 2.13E-2 3 / 32 175 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein 2.28E-2 4 / 83 catabolic process 176 positive regulation of protein serine/threonine kinase activity 2.28E-2 5 / 154 177 cysteine-type endopeptidase activity 2.29E-2 3 / 33 178 leukocyte apoptosis 2.29E-2 3 / 33 179 DNA strand elongation 2.68E-2 3 / 35 180 centrosome cycle 2.68E-2 3 / 35 181 positive regulation of response to DNA damage stimulus 2.68E-2 3 / 35 182 G2/M transition checkpoint 2.9E-2 3 / 36 183 cell-matrix adhesion 3.13E-2 4 / 91 184 transcription elongation, DNA-dependent 3.38E-2 4 / 93 185 positive regulation of protein phosphorylation 3.43E-2 5 / 170 186 transcription initiation, DNA-dependent 3.61E-2 4 / 95 187 regulation of membrane potential 3.61E-2 4 / 95 188 p53 binding 4.45E-2 3 / 42 189 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 4.75E-2 3 / 43 190 G2 phase of mitotic cell cycle 5.35E-2 2 / 10 191 G2 phase 5.35E-2 2 / 10 192 positive regulation of release of cytochrome c from mitochondria 5.35E-2 2 / 10 193 histone kinase activity 5.35E-2 2 / 10 194 death receptor binding 5.35E-2 2 / 10 195 regulation of cellular senescence 5.35E-2 2 / 10 196 proteasomal ubiquitin-dependent protein catabolic process 5.38E-2 5 / 190 197 protein domain specific binding 5.48E-2 6 / 292

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Function FDR Coverage 198 negative regulation of organelle organization 6.15E-2 4 / 111 199 regulation of osteoblast differentiation 6.21E-2 3 / 48 200 negative regulation of epithelial cell proliferation 6.21E-2 3 / 48 201 regulation of protein kinase B signaling cascade 6.56E-2 3 / 49 202 regulation of cellular component biogenesis 6.59E-2 5 / 200 203 positive regulation of neuron apoptosis 7.32E-2 2 / 12 204 positive regulation of leukocyte apoptosis 7.32E-2 2 / 12 205 negative regulation of apoptotic signaling pathway 7.32E-2 2 / 12 206 regulation of muscle cell apoptosis 7.32E-2 2 / 12 207 protein serine/threonine kinase inhibitor activity 7.32E-2 2 / 12 208 positive regulation of mitochondrion organization 7.32E-2 2 / 12 209 regulation of epithelial cell proliferation 7.32E-2 4 / 118 210 protein localization in membrane 7.48E-2 3 / 52 211 nuclear chromosome 7.52E-2 5 / 208 212 cell-substrate adhesion 8.18E-2 4 / 122 213 centrosome organization 8.23E-2 3 / 54 214 response to X-ray 8.24E-2 2 / 13 215 DNA damage response, signal transduction by p53 class mediator resulting in 8.24E-2 2 / 13 transcription of p21 class mediator 216 positive regulation of transforming growth factor beta receptor signaling pathway 8.24E-2 2 / 13 217 muscle cell apoptosis 8.24E-2 2 / 13 218 negative regulation of cyclin-dependent protein kinase activity 8.24E-2 2 / 13 219 enzyme activator activity 8.94E-2 5 / 218 220 mitosis 9.23E-2 5 / 220 221 nuclear division 9.23E-2 5 / 220 222 DNA damage response, signal transduction resulting in transcription 9.37E-2 2 / 14 223 negative regulation of protein kinase B signaling cascade 9.37E-2 2 / 14 224 protein kinase B signaling cascade 9.64E-2 3 / 58 225 epithelial cell proliferation 9.99E-2 4 / 131 226 negative regulation of cell adhesion 9.99E-2 3 / 59 227 microtubule organizing center organization 9.99E-2 3 / 59

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Interactions

Gene 1 Gene 2 Weight Network group Networks CCNA2 CDK1 0.11961824237369001 Co-expression Arijs-Rutgeerts-2009 Bild-Nevins-2006 B Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Jones-Libermann-2005 Kang-Willman-2010 Nakayama-Hasegawa-2007 Noble-Diehl-2008 Radtke-Downing-2009 Rieger-Chu-2004 Wang-Maris-2006 CDK1 CCNB1 0.10823668050579727 Co-expression Arijs-Rutgeerts-2009 Bild-Nevins-2006 B Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Jones-Libermann-2005 Kang-Willman-2010 Nakayama-Hasegawa-2007 Noble-Diehl-2008 Radtke-Downing-2009 Rieger-Chu-2004 Wang-Maris-2006 MCM2 PCNA 0.09379746997728944 Co-expression Arijs-Rutgeerts-2009 Bild-Nevins-2006 B Burington-Shaughnessy-2008 Jones-Libermann-2005 Kang-Willman-2010 Noble-Diehl-2008 Peng-Katze-2009 Radtke-Downing-2009 Wang-Maris-2006 CCNB1 RRM2 0.09076509601436555 Co-expression Arijs-Rutgeerts-2009 Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Jones-Libermann-2005 Kang-Willman-2010 Nakayama-Hasegawa-2007 Noble-Diehl-2008 Peng-Katze-2009 Radtke-Downing-2009 Wang-Maris-2006 CDK1 RRM2 0.08815223374404013 Co-expression Arijs-Rutgeerts-2009 Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Jones-Libermann-2005 Kang-Willman-2010 Nakayama-Hasegawa-2007 Radtke-Downing-2009 Raue-Trappe-2012 CCNA2 GTSE1 0.08790698414668441 Co-expression Bild-Nevins-2006 B Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Kang-Willman-2010 Nakayama-Hasegawa-2007 Rieger-Chu-2004 Wang-Maris-2006 PCNA CDK1 0.08310554223135114 Co-expression Bild-Nevins-2006 B Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006

第32页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks Nakayama-Hasegawa-2007 Noble-Diehl-2008 Peng-Katze-2009 Wang-Maris-2006 CCNA2 CCNB1 0.0782815720885992 Co-expression Arijs-Rutgeerts-2009 Bild-Nevins-2006 B Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Jones-Libermann-2005 Kang-Willman-2010 Nakayama-Hasegawa-2007 Noble-Diehl-2008 Radtke-Downing-2009 Rieger-Chu-2004 Wang-Maris-2006 CHEK1 RRM2 0.0737570789642632 Co-expression Arijs-Rutgeerts-2009 Gobble-Singer-2011 Jones-Libermann-2005 Nakayama-Hasegawa-2007 Raue-Trappe-2012 Rieger-Chu-2004 CDK1 CCNE2 0.07119963085278869 Co-expression Bild-Nevins-2006 B Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Nakayama-Hasegawa-2007 Radtke-Downing-2009 Wang-Maris-2006 CDK1 CCNB2 0.0697647042106837 Co-expression Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Jones-Libermann-2005 Nakayama-Hasegawa-2007 Peng-Katze-2009 Radtke-Downing-2009 Rieger-Chu-2004 Wang-Maris-2006 GADD45A CDKN1A 0.06243649870157242 Co-expression Gobble-Singer-2011 Noble-Diehl-2008 Rieger-Chu-2004 Wang-Maris-2006 CDC45 MCM2 0.06227491330355406 Co-expression Arijs-Rutgeerts-2009 Bild-Nevins-2006 B Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Kang-Willman-2010 Nakayama-Hasegawa-2007 Radtke-Downing-2009 PCNA CCNA2 0.06208584550768137 Co-expression Arijs-Rutgeerts-2009 Bild-Nevins-2006 B Gobble-Singer-2011 Hummel-Siebert-2006 Kang-Willman-2010 Wang-Maris-2006 CCNB2 GTSE1 0.061166544910520315 Co-expression Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Nakayama-Hasegawa-2007 Radtke-Downing-2009 Rieger-Chu-2004 Wang-Maris-2006 CDC45 CDK2 0.05988943297415972 Co-expression Arijs-Rutgeerts-2009 Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006

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Gene 1 Gene 2 Weight Network group Networks MCM2 CHEK1 0.05854673869907856 Co-expression Arijs-Rutgeerts-2009 Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Kang-Willman-2010 Radtke-Downing-2009 Rieger-Chu-2004 GADD45G GADD45B 0.05729491636157036 Co-expression Berchtold-Cotman-2008 Burczynski-Dorner-2006 Kang-Willman-2010 Peng-Katze-2009 CCNB2 RRM2 0.05685235443525016 Co-expression Burczynski-Dorner-2006 Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Nakayama-Hasegawa-2007 Radtke-Downing-2009 CCNB1 CHEK1 0.05429595988243818 Co-expression Arijs-Rutgeerts-2009 Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Jones-Libermann-2005 Nakayama-Hasegawa-2007 Wang-Maris-2006 CDC25C GTSE1 0.051891621202230453 Co-expression Nakayama-Hasegawa-2007 Noble-Diehl-2008 Wang-Maris-2006 CDC45 RRM2 0.051670132437720895 Co-expression Arijs-Rutgeerts-2009 Burington-Shaughnessy-2008 Gobble-Singer-2011 Peng-Katze-2009 Radtke-Downing-2009 Raue-Trappe-2012 CCNE2 CCNE1 0.05142363905906677 Co-expression Kang-Willman-2010 Radtke-Downing-2009 CDKN1A GADD45B 0.05128256417810917 Co-expression Kang-Willman-2010 Nakayama-Hasegawa-2007 Radtke-Downing-2009 CCNA2 RRM2 0.05087883025407791 Co-expression Arijs-Rutgeerts-2009 Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Kang-Willman-2010 Nakayama-Hasegawa-2007 Radtke-Downing-2009 Wang-Maris-2006 CCNA2 CHEK1 0.05040103197097778 Co-expression Arijs-Rutgeerts-2009 Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Jones-Libermann-2005 PCNA CHEK1 0.04996344540268183 Co-expression Kang-Willman-2010 Noble-Diehl-2008 Radtke-Downing-2009 MCM2 RRM2 0.04907896928489208 Co-expression Arijs-Rutgeerts-2009 Burington-Shaughnessy-2008 Gobble-Singer-2011 Jones-Libermann-2005 Kang-Willman-2010 Nakayama-Hasegawa-2007 Rieger-Chu-2004 Wang-Maris-2006 PCNA RRM2 0.048686676658689976 Co-expression Arijs-Rutgeerts-2009 Gobble-Singer-2011 Kang-Willman-2010 Nakayama-Hasegawa-2007 Radtke-Downing-2009

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Gene 1 Gene 2 Weight Network group Networks RRM2 CCNE2 0.04754148330539465 Co-expression Gobble-Singer-2011 Hummel-Siebert-2006 Nakayama-Hasegawa-2007 Radtke-Downing-2009 CHEK1 CCNB2 0.04684214200824499 Co-expression Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Nakayama-Hasegawa-2007 Peng-Katze-2009 Wang-Maris-2006 PCNA CCNB1 0.04655309487134218 Co-expression Arijs-Rutgeerts-2009 Bild-Nevins-2006 B Gobble-Singer-2011 Noble-Diehl-2008 Radtke-Downing-2009 Wang-Maris-2006 CASP2 TP53 0.04623447731137276 Co-expression Arijs-Rutgeerts-2009 Hummel-Siebert-2006 CCNB1 CCNB2 0.045636972412467 Co-expression Bild-Nevins-2006 B Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Jones-Libermann-2005 Nakayama-Hasegawa-2007 Radtke-Downing-2009 Rieger-Chu-2004 Wang-Maris-2006 CCND1 CCND2 0.04547930881381035 Co-expression Arijs-Rutgeerts-2009 Gobble-Singer-2011 MCM2 CCNA2 0.044249602826312184 Co-expression Arijs-Rutgeerts-2009 Bild-Nevins-2006 B Burington-Shaughnessy-2008 Kang-Willman-2010 Nakayama-Hasegawa-2007 Noble-Diehl-2008 Wang-Maris-2006 CDKN1A ZMAT3 0.043392875231802464 Co-expression Gobble-Singer-2011 Nakayama-Hasegawa-2007 Peng-Katze-2009 CDC25C CCNE2 0.043301332741975784 Co-expression Hummel-Siebert-2006 Wang-Maris-2006 CDC45 CCNB2 0.04266702034510672 Co-expression Bild-Nevins-2006 B Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Nakayama-Hasegawa-2007 Peng-Katze-2009 Wang-Maris-2006 CDC25C CCNA2 0.04242529673501849 Co-expression Arijs-Rutgeerts-2009 Burington-Shaughnessy-2008 Hummel-Siebert-2006 Rieger-Chu-2004 Wang-Maris-2006 TSC2 UBTF 0.042404626961797476 Co-expression Bild-Nevins-2006 B Gobble-Singer-2011 Hummel-Siebert-2006 Peng-Katze-2009 CDC25C CCNB2 0.04202159959822893 Co-expression Burington-Shaughnessy-2008 Gobble-Singer-2011 Noble-Diehl-2008 Rieger-Chu-2004 Wang-Maris-2006 CCNA2 CCNB2 0.04179609566926956 Co-expression Bild-Nevins-2006 B Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Nakayama-Hasegawa-2007

第35页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks Radtke-Downing-2009 Rieger-Chu-2004 Wang-Maris-2006 CCNA2 CCNE2 0.040632077027112246 Co-expression Burington-Shaughnessy-2008 Gobble-Singer-2011 Hummel-Siebert-2006 Noble-Diehl-2008 Wang-Maris-2006 CDK1 CDK2 0.039911895990371704 Co-expression Bild-Nevins-2006 B Burington-Shaughnessy-2008 Hummel-Siebert-2006 CDK1 GTSE1 0.037949813064187765 Co-expression Burington-Shaughnessy-2008 Gobble-Singer-2011 Radtke-Downing-2009 Wang-Maris-2006 MCM2 CCNB1 0.03781732195056975 Co-expression Arijs-Rutgeerts-2009 Bild-Nevins-2006 B Burington-Shaughnessy-2008 Gobble-Singer-2011 Jones-Libermann-2005 Nakayama-Hasegawa-2007 Wang-Maris-2006 CDKN1A FAS 0.03648679703474045 Co-expression Gobble-Singer-2011 Hummel-Siebert-2006 Rieger-Chu-2004 RRM2B ZMAT3 0.036327216774225235 Co-expression Arijs-Rutgeerts-2009 Peng-Katze-2009 MCM2 CDK2 0.0362358158454299 Co-expression Arijs-Rutgeerts-2009 Burington-Shaughnessy-2008 Rieger-Chu-2004 Wang-Maris-2006 CCND3 IGF1 0.03623343911021948 Co-expression Burington-Shaughnessy-2008 Nakayama-Hasegawa-2007 FAS ZMAT3 0.035707807168364525 Co-expression Gobble-Singer-2011 Hummel-Siebert-2006 Nakayama-Hasegawa-2007 CCNA1 CDK6 0.03475908562541008 Co-expression Bild-Nevins-2006 B Kang-Willman-2010 CDK1 CHEK1 0.03383446205407381 Co-expression Arijs-Rutgeerts-2009 Gobble-Singer-2011 Nakayama-Hasegawa-2007 SESN1 ZMAT3 0.033784166909754276 Co-expression Hummel-Siebert-2006 Noble-Diehl-2008 CCNB2 CCNE1 0.033378786873072386 Co-expression Bild-Nevins-2006 B Noble-Diehl-2008 Radtke-Downing-2009 WEE1 CDKN2A 0.03285888582468033 Co-expression Gobble-Singer-2011 MCM2 CDK4 0.03278625337406993 Co-expression Arijs-Rutgeerts-2009 Bild-Nevins-2006 B Burington-Shaughnessy-2008 Kang-Willman-2010 Radtke-Downing-2009 Wang-Maris-2006 CCNB1 GTSE1 0.03185467701405287 Co-expression Burington-Shaughnessy-2008 Gobble-Singer-2011 Nakayama-Hasegawa-2007 Rieger-Chu-2004 WEE1 CCNE2 0.03083912469446659 Co-expression Kang-Willman-2010 CDK4 ZMAT3 0.030478651635348797 Co-expression Burczynski-Dorner-2006 Gobble-Singer-2011 Nakayama-Hasegawa-2007 CDC45 CCNA2 0.03046239144168794 Co-expression Arijs-Rutgeerts-2009 Burington-Shaughnessy-2008 Gobble-Singer-2011 Kang-Willman-2010 Nakayama-Hasegawa-2007

第36页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks CCNG2 ZMAT3 0.03041737526655197 Co-expression Raue-Trappe-2012 CDKN1A BAX 0.029813808389008045 Co-expression Nakayama-Hasegawa-2007 Rieger-Chu-2004 IGF1 GADD45B 0.029508018866181374 Co-expression Perou-Botstein-1999 Wang-Maris-2006 PCNA CCNB2 0.029288868885487318 Co-expression Gobble-Singer-2011 Nakayama-Hasegawa-2007 Radtke-Downing-2009 Wang-Maris-2006 CCND3 FAS 0.02921666856855154 Co-expression Gobble-Singer-2011 Nakayama-Hasegawa-2007 CDC45 CCNE2 0.02881583385169506 Co-expression Bild-Nevins-2006 B Burington-Shaughnessy-2008 Rieger-Chu-2004 CDC25C CCNB1 0.028221786953508854 Co-expression Arijs-Rutgeerts-2009 Burington-Shaughnessy-2008 Rieger-Chu-2004 Wang-Maris-2006 TP53 PIDD 0.028141047805547714 Co-expression Jones-Libermann-2005 PCNA CYCS 0.028004045132547617 Co-expression Bild-Nevins-2006 B Burczynski-Dorner-2006 CDC45 GTSE1 0.027926335111260414 Co-expression Burington-Shaughnessy-2008 Gobble-Singer-2011 Nakayama-Hasegawa-2007 WEE1 CDK6 0.02770875208079815 Co-expression Arijs-Rutgeerts-2009 CDC25C CDK1 0.02767386194318533 Co-expression Burington-Shaughnessy-2008 Hummel-Siebert-2006 Wang-Maris-2006 CDK2 CHEK1 0.02765747159719467 Co-expression Kang-Willman-2010 Radtke-Downing-2009 PCNA CASP3 0.026684043928980827 Co-expression Nakayama-Hasegawa-2007 CCNB2 CCNE2 0.026575931115075946 Co-expression Burington-Shaughnessy-2008 Gobble-Singer-2011 Nakayama-Hasegawa-2007 Radtke-Downing-2009 WEE1 CDK1 0.026525875087827444 Co-expression Gobble-Singer-2011 Hummel-Siebert-2006 Wang-Maris-2006 CDKN2A CCNE1 0.026475440710783005 Co-expression Bild-Nevins-2006 B Burington-Shaughnessy-2008 CDC45 CCNB1 0.026464518392458558 Co-expression Arijs-Rutgeerts-2009 Bild-Nevins-2006 B Burington-Shaughnessy-2008 Gobble-Singer-2011 Nakayama-Hasegawa-2007 CDC45 CHEK1 0.026437451131641865 Co-expression Kang-Willman-2010 Peng-Katze-2009 CDK1 PMAIP1 0.025883130729198456 Co-expression Berchtold-Cotman-2008 GADD45A PCNA 0.025713065173476934 Co-expression Burczynski-Dorner-2006 Rieger-Chu-2004 GADD45A WEE1 0.025313198566436768 Co-expression Gobble-Singer-2011 WEE1 MCM2 0.025095417629927397 Co-expression Burington-Shaughnessy-2008 Radtke-Downing-2009 Wang-Maris-2006 CDKN1C CASP9 0.024437617510557175 Co-expression Kang-Willman-2010 POLR1C CCNE1 0.024129534140229225 Co-expression Burington-Shaughnessy-2008 Perou-Botstein-1999 TAF1A ZMAT3 0.024031277745962143 Co-expression Peng-Katze-2009 WEE1 PCNA 0.023762837052345276 Co-expression Burington-Shaughnessy-2008 Wang-Maris-2006 CDC45 CDC25C 0.023197543807327747 Co-expression Gobble-Singer-2011 Hummel-Siebert-2006 WEE1 CCNA2 0.02288165781646967 Co-expression Gobble-Singer-2011 Rieger-Chu-2004

第37页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks MCM2 CDK1 0.022537196520715952 Co-expression Bild-Nevins-2006 B Burington-Shaughnessy-2008 Gobble-Singer-2011 CCNA2 CCNE1 0.022431761492043734 Co-expression Bild-Nevins-2006 B Radtke-Downing-2009 CCND3 CDK4 0.02215944416821003 Co-expression Burczynski-Dorner-2006 Nakayama-Hasegawa-2007 GADD45A PMAIP1 0.021751834079623222 Co-expression Burczynski-Dorner-2006 Rieger-Chu-2004 CASP8 PMAIP1 0.0211580079048872 Co-expression Raue-Trappe-2012 SIAH1 CCNG2 0.021018315106630325 Co-expression Nakayama-Hasegawa-2007 MCM2 CCNE2 0.020765229128301144 Co-expression Bild-Nevins-2006 B Burington-Shaughnessy-2008 Gobble-Singer-2011 CDK4 CDKN2A 0.02059228904545307 Co-expression Nakayama-Hasegawa-2007 CCNG1 CCNG2 0.02050571935251355 Co-expression Jones-Libermann-2005 Peng-Katze-2009 PCNA PMAIP1 0.020493516698479652 Co-expression Burczynski-Dorner-2006 Rieger-Chu-2004 SFN PERP 0.020487094298005104 Co-expression Hummel-Siebert-2006 CDK4 CDK2 0.020454914774745703 Co-expression Arijs-Rutgeerts-2009 Hummel-Siebert-2006 TAF1A PERP 0.02028154768049717 Co-expression Nakayama-Hasegawa-2007 PTEN GADD45B 0.020213669165968895 Co-expression Arijs-Rutgeerts-2009 CDC45 PCNA 0.020108553115278482 Co-expression Radtke-Downing-2009 Wang-Maris-2006 GADD45G CCNG2 0.02000962570309639 Co-expression Kang-Willman-2010 PTEN CCNG1 0.01998024992644787 Co-expression Nakayama-Hasegawa-2007 FAS CDKN2A 0.01991993933916092 Co-expression Nakayama-Hasegawa-2007 CDKN1B CD82 0.019718650728464127 Co-expression Peng-Katze-2009 CCNG1 PMAIP1 0.019541094545274973 Co-expression Kang-Willman-2010 Rieger-Chu-2004 CASP3 CASP8 0.019223960116505623 Co-expression Burczynski-Dorner-2006 TP53 UBTF 0.018856141716241837 Co-expression Arijs-Rutgeerts-2009 Hummel-Siebert-2006 FAS GADD45B 0.01813516952097416 Co-expression Wang-Maris-2006 RRM2 GTSE1 0.017987738829106092 Co-expression Gobble-Singer-2011 Raue-Trappe-2012 TP53 CHEK1 0.017583835870027542 Co-expression Wang-Maris-2006 TP53 BID 0.01758098043501377 Co-expression Nakayama-Hasegawa-2007 PCNA CCNE2 0.017527879681438208 Co-expression Berchtold-Cotman-2008 Wang-Maris-2006 CCNA2 CDK2 0.017419525422155857 Co-expression Arijs-Rutgeerts-2009 Gobble-Singer-2011 CCNB1 CCNE2 0.017241015331819654 Co-expression Bild-Nevins-2006 B Burington-Shaughnessy-2008 Gobble-Singer-2011 TP53 CCNG1 0.017172779887914658 Co-expression Nakayama-Hasegawa-2007 BAG1 BAX 0.017135044559836388 Co-expression Peng-Katze-2009 CCNE1 GTSE1 0.016916565597057343 Co-expression Radtke-Downing-2009 TSC2 PIDD 0.016718916594982147 Co-expression Noble-Diehl-2008 Peng-Katze-2009 CYCS PERP 0.016663463786244392 Co-expression Peng-Katze-2009 RRM2B PTEN 0.01657065376639366 Co-expression Arijs-Rutgeerts-2009 GADD45G GTSE1 0.01651875488460064 Co-expression Peng-Katze-2009 CDC45 CDK1 0.016497473465278745 Co-expression Burington-Shaughnessy-2008 Gobble-Singer-2011 Radtke-Downing-2009 CDK4 CCND2 0.01649745274335146 Co-expression Arijs-Rutgeerts-2009 Noble-Diehl-2008 CASP8 RRM2 0.01634681411087513 Co-expression Bild-Nevins-2006 B CHEK1 EI24 0.016244135797023773 Co-expression Hummel-Siebert-2006

第38页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks CDK2 CCNE2 0.016236452385783195 Co-expression Bild-Nevins-2006 B CDC45 CCNE1 0.01608167216181755 Co-expression Gobble-Singer-2011 Noble-Diehl-2008 PCNA FAS 0.01577536202967167 Co-expression Rieger-Chu-2004 SIAH1 GADD45B 0.015525749884545803 Co-expression Berchtold-Cotman-2008 WEE1 CCNG1 0.015516298357397318 Co-expression Arijs-Rutgeerts-2009 Bild-Nevins-2006 B CDKN1C CCNE2 0.015487337484955788 Co-expression Burington-Shaughnessy-2008 CASP3 PMAIP1 0.015464507974684238 Co-expression Jones-Libermann-2005 MCM2 GTSE1 0.015460561495274305 Co-expression Burington-Shaughnessy-2008 Nakayama-Hasegawa-2007 CDC45 CDK4 0.015421230811625719 Co-expression Bild-Nevins-2006 B Rieger-Chu-2004 RRM2B SESN1 0.015413199551403522 Co-expression Peng-Katze-2009 CCND3 SESN2 0.015082687139511108 Co-expression Noble-Diehl-2008 CDKN1B SIAH1 0.015038499608635902 Co-expression Jones-Libermann-2005 Raue-Trappe-2012 SFN APAF1 0.01497987937182188 Co-expression Rieger-Chu-2004 FAS CCNG1 0.014640942215919495 Co-expression Rieger-Chu-2004 TAF1A SESN3 0.014467986300587654 Co-expression Noble-Diehl-2008 GADD45B PMAIP1 0.014460091479122639 Co-expression Radtke-Downing-2009 PCNA CDK2 0.014331378042697906 Co-expression Burington-Shaughnessy-2008 MCM2 CDC25C 0.014316031243652105 Co-expression Burington-Shaughnessy-2008 Wang-Maris-2006 PTCH1 CCND2 0.014248890802264214 Co-expression Perou-Botstein-1999 BAG1 CASP9 0.014021304436028004 Co-expression Arijs-Rutgeerts-2009 CASP3 RRM2 0.013865148648619652 Co-expression Burington-Shaughnessy-2008 CCND3 CDKN1A 0.01384005881845951 Co-expression Gobble-Singer-2011 CDKN1B CASP3 0.01369414757937193 Co-expression Rieger-Chu-2004 BCL2L1 THBS1 0.013560386374592781 Co-expression Bild-Nevins-2006 B CDK1 BID 0.013352513313293457 Co-expression Jones-Libermann-2005 GADD45A SESN2 0.013145461678504944 Co-expression Raue-Trappe-2012 CDKN1C CD82 0.013137726113200188 Co-expression Arijs-Rutgeerts-2009 CHEK1 CCNE2 0.013070262037217617 Co-expression Bild-Nevins-2006 B CDKN1B ATR 0.012933192774653435 Co-expression Nakayama-Hasegawa-2007 CYCS PMAIP1 0.012867875397205353 Co-expression Burczynski-Dorner-2006 SESN1 CCNG1 0.012703897431492805 Co-expression Hummel-Siebert-2006 BAX SESN2 0.012621169909834862 Co-expression Noble-Diehl-2008 CYCS CCNG1 0.012516082264482975 Co-expression Burczynski-Dorner-2006 CCND3 TP53 0.012370366603136063 Co-expression Peng-Katze-2009 CDKN1B CDK6 0.012361851520836353 Co-expression Arijs-Rutgeerts-2009 GADD45A CDK2 0.012276171706616879 Co-expression Berchtold-Cotman-2008 BID APAF1 0.012265260331332684 Co-expression Bild-Nevins-2006 B FAS PMAIP1 0.012058794498443604 Co-expression Rieger-Chu-2004 SESN1 CCND3 0.012009207159280777 Co-expression Nakayama-Hasegawa-2007 WEE1 CCNB1 0.011959901079535484 Co-expression Rieger-Chu-2004 CDK4 POLR1C 0.011857965029776096 Co-expression Burington-Shaughnessy-2008 Raue-Trappe-2012 SESN1 IGF1 0.011807999573647976 Co-expression Gobble-Singer-2011 GADD45A GADD45B 0.011639367789030075 Co-expression Berchtold-Cotman-2008 CCNA1 CDC25C 0.011592529714107513 Co-expression Nakayama-Hasegawa-2007 PTEN SIAH1 0.011456764303147793 Co-expression Noble-Diehl-2008 UBTF TCOF1 0.011311623733490705 Co-expression Hummel-Siebert-2006 Peng-Katze-2009 BID CCND2 0.011286634020507336 Co-expression Noble-Diehl-2008 GADD45A FAS 0.011196209117770195 Co-expression Rieger-Chu-2004 GADD45A SESN1 0.01113199070096016 Co-expression Kang-Willman-2010 PCNA CCNG1 0.01099251490086317 Co-expression Rieger-Chu-2004 IGF1 ZMAT3 0.010907256975769997 Co-expression Gobble-Singer-2011 CDC45 CDKN2A 0.010885429568588734 Co-expression Bild-Nevins-2006 B

第39页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks POLR1D CCNG1 0.010860822163522243 Co-expression Arijs-Rutgeerts-2009 TAF1A SIAH1 0.010840664617717266 Co-expression Burington-Shaughnessy-2008 CDKN2A CCNG1 0.010704196989536285 Co-expression Rieger-Chu-2004 CDK2 TP73 0.010699618607759476 Co-expression Jones-Libermann-2005 TAF1A WEE1 0.010683858767151833 Co-expression Hummel-Siebert-2006 CCND1 UBTF 0.010620313696563244 Co-expression Burington-Shaughnessy-2008 TP73 GTSE1 0.010514381341636181 Co-expression Jones-Libermann-2005 CDC25C CHEK1 0.010489242151379585 Co-expression Burington-Shaughnessy-2008 CCNB1 BID 0.01034094113856554 Co-expression Jones-Libermann-2005 SESN1 PTEN 0.010244937613606453 Co-expression Noble-Diehl-2008 RRM2 CCND2 0.010204456746578217 Co-expression Rieger-Chu-2004 CCND2 ZMAT3 0.010161674581468105 Co-expression Gobble-Singer-2011 BAX SFN 0.010065972805023193 Co-expression Noble-Diehl-2008 CDC25C PCNA 0.009875217452645302 Co-expression Wang-Maris-2006 CASP8 FAS 0.009870187379419804 Co-expression Hummel-Siebert-2006 PCNA CDKN1A 0.009817876853048801 Co-expression Rieger-Chu-2004 BCL2L1 CD82 0.009712085127830505 Co-expression Arijs-Rutgeerts-2009 WEE1 CDC45 0.009458331391215324 Co-expression Gobble-Singer-2011 TP53 CDK6 0.00944862887263298 Co-expression Arijs-Rutgeerts-2009 CDK2 CCND1 0.009361660107970238 Co-expression Noble-Diehl-2008 CCNG1 EI24 0.009292639791965485 Co-expression Rieger-Chu-2004 CCND3 CCND1 0.00929186213761568 Co-expression Gobble-Singer-2011 CASP3 CCND2 0.009122966788709164 Co-expression Radtke-Downing-2009 PTCH1 SESN1 0.00901471171528101 Co-expression Arijs-Rutgeerts-2009 CCNA2 PMAIP1 0.008997752796858549 Co-expression Gobble-Singer-2011 Noble-Diehl-2008 RRM2B PCNA 0.008819404058158398 Co-expression Peng-Katze-2009 WEE1 TP53 0.008814194239675999 Co-expression Arijs-Rutgeerts-2009 CDKN1A CCNG1 0.00880659744143486 Co-expression Rieger-Chu-2004 BAG1 SFN 0.008799215778708458 Co-expression Noble-Diehl-2008 TP53 SFN 0.00876920111477375 Co-expression Berchtold-Cotman-2008 CASP3 BID 0.00876569002866745 Co-expression Jones-Libermann-2005 GADD45A BCL2 0.008733739145100117 Co-expression Rieger-Chu-2004 TP53 CDK4 0.00869476783555001 Co-expression Arijs-Rutgeerts-2009 Kang-Willman-2010 MCM2 CCNB2 0.008678418351337314 Co-expression Gobble-Singer-2011 Nakayama-Hasegawa-2007 Wang-Maris-2006 SFN CCND2 0.008669858798384666 Co-expression Burington-Shaughnessy-2008 CDK4 CDKN1A 0.008544246666133404 Co-expression Gobble-Singer-2011 CDK1 PTEN 0.008484677411615849 Co-expression Wang-Maris-2006 PIDD TCOF1 0.008457317017018795 Co-expression Peng-Katze-2009 BID POLR1C 0.008342456072568893 Co-expression Noble-Diehl-2008 CDKN1A SFN 0.008311357349157333 Co-expression Berchtold-Cotman-2008 SFN CCNB2 0.008243299089372158 Co-expression Jones-Libermann-2005 CCNA2 CASP3 0.008085785433650017 Co-expression Nakayama-Hasegawa-2007 CDK4 CCNE1 0.008074775338172913 Co-expression Rieger-Chu-2004 CCND1 ZMAT3 0.007920482195913792 Co-expression Gobble-Singer-2011 GADD45A EI24 0.007734266109764576 Co-expression Rieger-Chu-2004 CDKN1C CDKN1B 0.00764109194278717 Co-expression Raue-Trappe-2012 GADD45A CCNG1 0.00762916449457407 Co-expression Rieger-Chu-2004 MCM2 CASP3 0.007625190075486898 Co-expression Nakayama-Hasegawa-2007 CDK1 CDKN2A 0.007598143070936203 Co-expression Gobble-Singer-2011 WEE1 RRM2 0.007482615765184164 Co-expression Gobble-Singer-2011 CDKN1A PMAIP1 0.007438319269567728 Co-expression Rieger-Chu-2004 CDK6 CCNE2 0.007376241497695446 Co-expression Berchtold-Cotman-2008 CDK2 ATR 0.0073715816251933575 Co-expression Rieger-Chu-2004 PMAIP1 EI24 0.007356912363320589 Co-expression Rieger-Chu-2004 CDK4 CCND1 0.007130438927561045 Co-expression Gobble-Singer-2011

第40页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks CCNB1 EI24 0.007075076922774315 Co-expression Radtke-Downing-2009 BID CCNB2 0.006632666569203138 Co-expression Jones-Libermann-2005 CCNA2 TP53 0.006591427139937878 Co-expression Noble-Diehl-2008 MCM2 TCOF1 0.006491493433713913 Co-expression Wang-Maris-2006 MCM2 CASP9 0.0064543187618255615 Co-expression Gobble-Singer-2011 CDC45 POLR1C 0.0063569387421011925 Co-expression Wang-Maris-2006 BAX RRM2 0.006308245472609997 Co-expression Gobble-Singer-2011 CDKN2A CCNB2 0.006273961625993252 Co-expression Gobble-Singer-2011 CDK2 CCNB2 0.00600191717967391 Co-expression Wang-Maris-2006 CDK1 CCNE1 0.00599427055567503 Co-expression Radtke-Downing-2009 MCM2 UBTF 0.005992111749947071 Co-expression Burington-Shaughnessy-2008 GADD45A RRM2 0.00580297177657485 Co-expression Radtke-Downing-2009 WEE1 CCNB2 0.005796590819954872 Co-expression Gobble-Singer-2011 RRM2B TP53 0.0057794018648564816 Co-expression Arijs-Rutgeerts-2009 RRM2 CCNE1 0.0057095312513411045 Co-expression Radtke-Downing-2009 CDK4 CYCS 0.005378367844969034 Co-expression Kang-Willman-2010 CDK4 CCNB1 0.00535627594217658 Co-expression Wang-Maris-2006 MCM2 BAX 0.005249472800642252 Co-expression Gobble-Singer-2011 CDK4 BAX 0.004917737562209368 Co-expression Kang-Willman-2010 CCNB1 CYCS 0.004634564276784658 Co-expression Bild-Nevins-2006 B BAG1 BCL2L1 0.004381242673844099 Co-expression Burczynski-Dorner-2006 SIAH1 CCNG1 0.0043023633770644665 Co-expression Noble-Diehl-2008 CASP2 CDK4 0.00416868831962347 Co-expression Arijs-Rutgeerts-2009 CCNB1 CDKN2A 0.003908342681825161 Co-expression Burington-Shaughnessy-2008 MCM2 CCNE1 0.0033697006292641163 Co-expression Gobble-Singer-2011 CCNB3 CCNE2 0.002911478979513049 Co-expression Berchtold-Cotman-2008 GADD45G GADD45B 0.02637244015932083 Co-localization Johnson-Shoemaker-2003 BCL2 TSC2 0.018628498539328575 Co-localization Johnson-Shoemaker-2003 GADD45A IGF1 0.017941070720553398 Co-localization Schadt-Shoemaker-2004 CDK4 CDK6 0.017806531861424446 Co-localization Schadt-Shoemaker-2004 CHEK1 CDK6 0.017451552441343665 Co-localization Johnson-Shoemaker-2003 Schadt-Shoemaker-2004 PTEN CCNG2 0.017365794628858566 Co-localization Johnson-Shoemaker-2003 BCL2L1 BID 0.01722104847431183 Co-localization Schadt-Shoemaker-2004 CASP2 CDK6 0.01645035669207573 Co-localization Johnson-Shoemaker-2003 Schadt-Shoemaker-2004 CDKN1A GADD45B 0.015296680852770805 Co-localization Johnson-Shoemaker-2003 TP53 TCOF1 0.015287617221474648 Co-localization Johnson-Shoemaker-2003 CDK1 FAS 0.014934340957552195 Co-localization Johnson-Shoemaker-2003 Schadt-Shoemaker-2004 CCNA2 CHEK1 0.01482504396699369 Co-localization Johnson-Shoemaker-2003 Schadt-Shoemaker-2004 CASP2 CCND3 0.014692964032292366 Co-localization Johnson-Shoemaker-2003 Schadt-Shoemaker-2004 CDKN2A CASP9 0.014605747535824776 Co-localization Schadt-Shoemaker-2004 CCNA2 CDK6 0.014028445817530155 Co-localization Schadt-Shoemaker-2004 CASP3 BID 0.013852749019861221 Co-localization Johnson-Shoemaker-2003 WEE1 CDK1 0.012855200096964836 Co-localization Johnson-Shoemaker-2003 CDKN1A GADD45G 0.01282262522727251 Co-localization Johnson-Shoemaker-2003 CDC25C GTSE1 0.012768813408911228 Co-localization Johnson-Shoemaker-2003 CDKN1A TP73 0.011897487565875053 Co-localization Johnson-Shoemaker-2003 CASP2 CHEK1 0.011890115216374397 Co-localization Johnson-Shoemaker-2003 Schadt-Shoemaker-2004 BCL2L1 CDKN2A 0.011887186206877232 Co-localization Schadt-Shoemaker-2004 CDC45 CDK6 0.011883124709129333 Co-localization Johnson-Shoemaker-2003 FAS CDKN2A 0.011716515757143497 Co-localization Schadt-Shoemaker-2004 CASP2 CCNA2 0.0116383854765445 Co-localization Johnson-Shoemaker-2003 Schadt-Shoemaker-2004 CDKN1B CCNG2 0.011631970293819904 Co-localization Johnson-Shoemaker-2003 TP53 UBTF 0.011607907712459564 Co-localization Johnson-Shoemaker-2003

第41页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks CCNA2 BCL2L1 0.011511623859405518 Co-localization Schadt-Shoemaker-2004 CDK4 TCOF1 0.010994071140885353 Co-localization Schadt-Shoemaker-2004 CDKN1B TSC2 0.010981008410453796 Co-localization Johnson-Shoemaker-2003 CDK2 BAX 0.010868124663829803 Co-localization Johnson-Shoemaker-2003 CDK4 CDK2 0.01067382749170065 Co-localization Schadt-Shoemaker-2004 BCL2L1 APAF1 0.010394466109573841 Co-localization Johnson-Shoemaker-2003 CCND3 FAS 0.01027767825871706 Co-localization Schadt-Shoemaker-2004 CDK1 CDK6 0.01024220883846283 Co-localization Schadt-Shoemaker-2004 PCNA TCOF1 0.009999655187129974 Co-localization Johnson-Shoemaker-2003 BCL2L1 CHEK1 0.009919615462422371 Co-localization Schadt-Shoemaker-2004 CCND3 CDKN2A 0.009674561209976673 Co-localization Schadt-Shoemaker-2004 CDK6 TCOF1 0.009653248824179173 Co-localization Schadt-Shoemaker-2004 CDC45 CASP2 0.009608132764697075 Co-localization Johnson-Shoemaker-2003 CDK1 CDK4 0.009435086511075497 Co-localization Schadt-Shoemaker-2004 CDK1 CHEK1 0.008913552388548851 Co-localization Schadt-Shoemaker-2004 BCL2L1 TCOF1 0.008905437774956226 Co-localization Schadt-Shoemaker-2004 CCNA2 CDK1 0.008866691961884499 Co-localization Schadt-Shoemaker-2004 BCL2L1 CCND3 0.008706340566277504 Co-localization Schadt-Shoemaker-2004 CCND3 CASP9 0.008686104789376259 Co-localization Schadt-Shoemaker-2004 CCNA2 TCOF1 0.008680559694766998 Co-localization Schadt-Shoemaker-2004 CASP8 FAS 0.008670112118124962 Co-localization Schadt-Shoemaker-2004 PCNA CCNB2 0.008615883067250252 Co-localization Johnson-Shoemaker-2003 CHEK1 TCOF1 0.008121104910969734 Co-localization Schadt-Shoemaker-2004 CDKN1A THBS1 0.007962229661643505 Co-localization Johnson-Shoemaker-2003 CASP2 SIAH1 0.007932894863188267 Co-localization Johnson-Shoemaker-2003 CDK2 CDK6 0.007881532423198223 Co-localization Schadt-Shoemaker-2004 CASP2 CDK1 0.007439239416271448 Co-localization Schadt-Shoemaker-2004 CCND3 CDK6 0.007266344502568245 Co-localization Johnson-Shoemaker-2003 BCL2L1 CDK1 0.0072359805926680565 Co-localization Schadt-Shoemaker-2004 CASP3 CDK6 0.007221854291856289 Co-localization Johnson-Shoemaker-2003 CASP8 CDKN1A 0.007188822608441114 Co-localization Schadt-Shoemaker-2004 CDKN2A TCOF1 0.007170332130044699 Co-localization Schadt-Shoemaker-2004 CCNB1 TCOF1 0.007153289392590523 Co-localization Johnson-Shoemaker-2003 CCNB1 CCNB2 0.007099518086761236 Co-localization Johnson-Shoemaker-2003 CCNA2 CCNB2 0.007074044086039066 Co-localization Johnson-Shoemaker-2003 CASP2 TCOF1 0.006914705969393253 Co-localization Schadt-Shoemaker-2004 CDC45 CCNA2 0.006727628409862518 Co-localization Johnson-Shoemaker-2003 CCNA2 CDK2 0.006536458618938923 Co-localization Schadt-Shoemaker-2004 CCND3 TCOF1 0.0064285630360245705 Co-localization Schadt-Shoemaker-2004 CDC45 CHEK1 0.006281326990574598 Co-localization Johnson-Shoemaker-2003 CCNA2 BID 0.006192447617650032 Co-localization Johnson-Shoemaker-2003 CHEK1 CCNB2 0.006145148538053036 Co-localization Johnson-Shoemaker-2003 CDK1 TCOF1 0.006109099369496107 Co-localization Schadt-Shoemaker-2004 CDK2 CHEK1 0.00609638961032033 Co-localization Schadt-Shoemaker-2004 CCND3 CDK1 0.005980865564197302 Co-localization Schadt-Shoemaker-2004 CASP2 CDK2 0.005953071638941765 Co-localization Schadt-Shoemaker-2004 CDK4 CCNB1 0.005868089385330677 Co-localization Johnson-Shoemaker-2003 CASP8 CHEK1 0.0058124312199652195 Co-localization Schadt-Shoemaker-2004 CDC45 CCNB1 0.005797147285193205 Co-localization Johnson-Shoemaker-2003 CCND3 CASP8 0.005720839835703373 Co-localization Schadt-Shoemaker-2004 CASP2 CASP3 0.005692847538739443 Co-localization Johnson-Shoemaker-2003 CASP2 CASP8 0.005657930392771959 Co-localization Schadt-Shoemaker-2004 CDK1 CDK2 0.005456279963254929 Co-localization Schadt-Shoemaker-2004 CCNA2 SIAH1 0.005404502619057894 Co-localization Johnson-Shoemaker-2003 CASP2 GTSE1 0.005222998559474945 Co-localization Johnson-Shoemaker-2003 CDK2 TCOF1 0.005096306558698416 Co-localization Schadt-Shoemaker-2004 SIAH1 CHEK1 0.00498700886964798 Co-localization Johnson-Shoemaker-2003 CDK1 CASP8 0.004902044776827097 Co-localization Schadt-Shoemaker-2004 PCNA TP53 0.004877858329564333 Co-localization Johnson-Shoemaker-2003

第42页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks PCNA CDK1 0.0047284564934670925 Co-localization Johnson-Shoemaker-2003 CDK2 CASP8 0.00454379478469491 Co-localization Schadt-Shoemaker-2004 CCNA2 CCND3 0.004277974367141724 Co-localization Johnson-Shoemaker-2003 CCNA2 CASP3 0.004081894643604755 Co-localization Johnson-Shoemaker-2003 CASP3 CHEK1 0.0036936469841748476 Co-localization Johnson-Shoemaker-2003 CCND3 CHEK1 0.0036267212126404047 Co-localization Johnson-Shoemaker-2003 PCNA CCNA2 0.002847034716978669 Co-localization Johnson-Shoemaker-2003 PCNA CCNB1 0.002669217996299267 Co-localization Johnson-Shoemaker-2003 CCNA2 CCNB1 0.0021343594416975975 Co-localization Johnson-Shoemaker-2003 CCNB1 CHEK1 0.0018698849016800523 Co-localization Johnson-Shoemaker-2003 BAG1 SIAH1 0.7962251901626587 Genetic interactions IREF-SMALL-SCALE-STUDIES CASP2 BCL2 0.7821764945983887 Genetic interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES TP53 TSC2 0.7708145081996918 Genetic interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES CASP2 CASP9 0.5964033603668213 Genetic interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES CASP2 BCL2L1 0.5964033603668213 Genetic interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES CASP8 CASP9 0.5484272241592407 Genetic interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES BCL2L1 CASP8 0.5484272241592407 Genetic interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES BAG1 TP53 0.4722375273704529 Genetic interactions BIOGRID-SMALL-SCALE-STUDIES IREF-SMALL-SCALE-STUDIES CASP2 BID 0.47144198417663574 Genetic interactions IREF-SMALL-SCALE-STUDIES CASP3 CASP8 0.4369906783103943 Genetic interactions IREF-SMALL-SCALE-STUDIES BCL2 CASP8 0.29364442825317383 Genetic interactions BIOGRID-SMALL-SCALE-STUDIES CASP2 CASP8 0.08092600852251053 Genetic interactions IREF-SMALL-SCALE-STUDIES CDK2 CCNE1 0.7502048406749964 Pathway PATHWAYCOMMONS-CELL_MAP Wu-Stein-2010 CDK4 CDK6 0.7374638058245182 Pathway PATHWAYCOMMONS-CELL_MAP Wu-Stein-2010 CDK4 CCND1 0.7194370431825519 Pathway PATHWAYCOMMONS-CELL_MAP Wu-Stein-2010 CASP9 APAF1 0.7178014405071735 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 CDK1 CCNB2 0.6170677300542593 Pathway PATHWAYCOMMONS-CELL_MAP Wu-Stein-2010 PTCH1 CCNB1 0.5031448900699615 Pathway PATHWAYCOMMONS-CELL_MAP Wu-Stein-2010 WEE1 CCNB1 0.3597080409526825 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 CDK1 CCNB1 0.3529827636666596 Pathway PATHWAYCOMMONS-CELL_MAP Wu-Stein-2010 WEE1 CDK1 0.2810237817466259 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 WEE1 CHEK1 0.2745307385921478 Pathway Wu-Stein-2010 PTCH1 CDK1 0.2670623753219843 Pathway PATHWAYCOMMONS-CELL_MAP Wu-Stein-2010 TP53 PERP 0.22864551097154617 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 SESN1 TP53 0.22864551097154617 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 GADD45G GTSE1 0.22110183537006378 Pathway Wu-Stein-2010 BCL2L1 PMAIP1 0.19874905049800873 Pathway Wu-Stein-2010 GADD45B GTSE1 0.16862043738365173 Pathway Wu-Stein-2010 CDC25C GTSE1 0.16537591814994812 Pathway Wu-Stein-2010 CCND1 CDK6 0.15984252095222473 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 GADD45A GTSE1 0.1433916836977005 Pathway Wu-Stein-2010 BCL2 PMAIP1 0.1386234611272812 Pathway Wu-Stein-2010

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Gene 1 Gene 2 Weight Network group Networks CDC25C CHEK1 0.1271761804819107 Pathway Wu-Stein-2010 WEE1 CCNE2 0.12520483136177063 Pathway Wu-Stein-2010 CDKN1C CCNA2 0.11835538595914841 Pathway Wu-Stein-2010 CCNB3 GADD45G 0.11711738258600235 Pathway Wu-Stein-2010 CDK2 CCNE2 0.11655965633690357 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 TP53 SESN3 0.11060363799333572 Pathway Wu-Stein-2010 TP53 SESN2 0.11060363799333572 Pathway Wu-Stein-2010 TP53 EI24 0.11060363799333572 Pathway Wu-Stein-2010 TP53 ZMAT3 0.11060363799333572 Pathway Wu-Stein-2010 TP53 CCNG2 0.11060363799333572 Pathway Wu-Stein-2010 CCNA2 CCNE1 0.10879409313201904 Pathway PATHWAYCOMMONS-NCI_NATURE CCNA2 CDK2 0.10509457997977734 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 CDC25C GADD45G 0.10464778542518616 Pathway Wu-Stein-2010 CCNB3 GADD45B 0.08931804448366165 Pathway Wu-Stein-2010 BAX CYCS 0.08498328365385532 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 WEE1 CCNE1 0.08400891721248627 Pathway Wu-Stein-2010 CASP8 FAS 0.08328072354197502 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 CHEK1 ATR 0.08250155113637447 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 CCNA1 CDKN1C 0.08058399707078934 Pathway Wu-Stein-2010 CDC25C GADD45B 0.07980827242136002 Pathway Wu-Stein-2010 CYCS BID 0.07902409136295319 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 GADD45A CCNB3 0.07595440000295639 Pathway Wu-Stein-2010 CCNB2 GADD45G 0.0745689645409584 Pathway Wu-Stein-2010 SFN GTSE1 0.0733904093503952 Pathway Wu-Stein-2010 BAX APAF1 0.07286233454942703 Pathway Wu-Stein-2010 CASP2 PIDD 0.070276640355587 Pathway Wu-Stein-2010 TP53 PMAIP1 0.07005425542593002 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 GADD45A CDC25C 0.0678674653172493 Pathway Wu-Stein-2010 CDKN1C CCNE2 0.06738951057195663 Pathway Wu-Stein-2010 TAF1A UBTF 0.06498322635889053 Pathway Wu-Stein-2010 TP53 TP73 0.06497168354690075 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 UBTF POLR1C 0.06420204043388367 Pathway Wu-Stein-2010 TAF1A POLR1C 0.06364250183105469 Pathway Wu-Stein-2010 CDKN1C CDK6 0.06277381628751755 Pathway Wu-Stein-2010 CCND3 CDKN2A 0.06051674857735634 Pathway Wu-Stein-2010 PCNA GADD45G 0.06044639274477959 Pathway Wu-Stein-2010 CCNB2 GADD45B 0.05686905235052109 Pathway Wu-Stein-2010 CDC25C CCNB2 0.05577480047941208 Pathway Wu-Stein-2010 CDKN1C CCND2 0.05372304469347 Pathway Wu-Stein-2010 CCNA2 ATR 0.052273254841566086 Pathway PATHWAYCOMMONS-NCI_NATURE CDKN1C CDK4 0.05109797418117523 Pathway Wu-Stein-2010 BCL2 CASP3 0.05095739662647247 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 CCND3 CDK6 0.04988112300634384 Pathway Wu-Stein-2010 GADD45A CCNB2 0.04836038127541542 Pathway Wu-Stein-2010 CDKN1B CDK2 0.04780299589037895 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 CDK2 ATR 0.04758132062852383 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 SFN GADD45G 0.046440523117780685 Pathway Wu-Stein-2010 CASP3 BAX 0.04629217088222504 Pathway PATHWAYCOMMONS-NCI_NATURE PCNA GADD45B 0.046098656952381134 Pathway Wu-Stein-2010

第44页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks BAX BID 0.04606245830655098 Pathway Wu-Stein-2010 BCL2L1 BAX 0.045534465461969376 Pathway Wu-Stein-2010 CDK6 CDKN2A 0.04524530842900276 Pathway Wu-Stein-2010 CDKN1C CCNE1 0.04521647095680237 Pathway Wu-Stein-2010 WEE1 CDK2 0.04345002770423889 Pathway Wu-Stein-2010 CCND3 CCND2 0.04268922656774521 Pathway Wu-Stein-2010 BCL2L1 APAF1 0.0416213795542717 Pathway Wu-Stein-2010 CCND3 CDK4 0.04060330241918564 Pathway Wu-Stein-2010 CDK2 CDKN1A 0.0405024578794837 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 TP53 CCNG1 0.040079958736896515 Pathway Wu-Stein-2010 CCNB1 GADD45G 0.039548441767692566 Pathway Wu-Stein-2010 GADD45A PCNA 0.039201438426971436 Pathway Wu-Stein-2010 CCNB3 SFN 0.03887481242418289 Pathway Wu-Stein-2010 CDKN2A CCND2 0.038721807301044464 Pathway Wu-Stein-2010 CDK6 CCNB2 0.03849906101822853 Pathway Wu-Stein-2010 CDK4 CDKN2A 0.03682974725961685 Pathway Wu-Stein-2010 SFN GADD45B 0.035417258739471436 Pathway Wu-Stein-2010 CDC25C SFN 0.034735776484012604 Pathway Wu-Stein-2010 CDK6 CCND2 0.03191657364368439 Pathway Wu-Stein-2010 BCL2 BAX 0.03175937384366989 Pathway Wu-Stein-2010 CDK4 CCNB2 0.031338293105363846 Pathway Wu-Stein-2010 UBTF POLR1D 0.03133455663919449 Pathway Wu-Stein-2010 CCNA2 CDKN1B 0.03122756816446781 Pathway Wu-Stein-2010 PCNA CDK6 0.031207749620079994 Pathway Wu-Stein-2010 TAF1A POLR1D 0.03106146864593029 Pathway Wu-Stein-2010 POLR1C POLR1D 0.03068806603550911 Pathway Wu-Stein-2010 TP53 PIDD 0.030317651107907295 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 CCNB1 GADD45B 0.03016110323369503 Pathway Wu-Stein-2010 GADD45A SFN 0.030118176713585854 Pathway Wu-Stein-2010 CCNA2 CDKN1A 0.02966604009270668 Pathway Wu-Stein-2010 CDC25C CCNB1 0.02958075702190399 Pathway Wu-Stein-2010 BCL2 APAF1 0.029030075296759605 Pathway Wu-Stein-2010 ATR CDKN2A 0.0279016625136137 Pathway Wu-Stein-2010 TP53 CD82 0.027650712057948112 Pathway PATHWAYCOMMONS-NCI_NATURE PCNA CCND2 0.026708193123340607 Pathway Wu-Stein-2010 BCL2L1 BID 0.02631240338087082 Pathway Wu-Stein-2010 CDK4 CCND2 0.025980137288570404 Pathway Wu-Stein-2010 FAS BID 0.025790637359023094 Pathway Wu-Stein-2010 GADD45A CCNB1 0.025648439303040504 Pathway Wu-Stein-2010 CDKN1C CCND1 0.02549716643989086 Pathway Wu-Stein-2010 PCNA CDK4 0.025403151288628578 Pathway Wu-Stein-2010 CDC45 MCM2 0.024821028113365173 Pathway Wu-Stein-2010 SFN CCNB2 0.024751702323555946 Pathway Wu-Stein-2010 CDK6 SFN 0.023976683616638184 Pathway Wu-Stein-2010 PCNA TP53 0.023898879066109657 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 SIAH1 CYCS 0.02352522499859333 Pathway Wu-Stein-2010 CDKN1C CDK2 0.023386290296912193 Pathway Wu-Stein-2010 CASP2 FAS 0.022875646129250526 Pathway Wu-Stein-2010 CDK1 GADD45G 0.022562485188245773 Pathway Wu-Stein-2010 PCNA CCNE1 0.022479185834527016 Pathway Wu-Stein-2010 TP53 APAF1 0.022246117237955332 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 CCNA2 CDK1 0.021962838247418404 Pathway Wu-Stein-2010 CYCS APAF1 0.02150375209748745 Pathway Wu-Stein-2010 CCNA1 CDKN1B 0.02126174606382847 Pathway Wu-Stein-2010 CCNB1 CDK6 0.020418385043740273 Pathway Wu-Stein-2010

第45页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks CCND3 CCND1 0.02026047371327877 Pathway Wu-Stein-2010 CCNA1 CDKN1A 0.020198557525873184 Pathway Wu-Stein-2010 CDK4 SFN 0.01951705478131771 Pathway Wu-Stein-2010 SFN TSC2 0.019278453662991524 Pathway Wu-Stein-2010 GADD45A CCND1 0.01902773603796959 Pathway Wu-Stein-2010 CDC45 ATR 0.018985716626048088 Pathway Wu-Stein-2010 CCNB3 CDK1 0.018886789679527283 Pathway Wu-Stein-2010 MCM2 ATR 0.01854129508137703 Pathway Wu-Stein-2010 CCND1 CDKN2A 0.018377522006630898 Pathway Wu-Stein-2010 BCL2 BID 0.01835237257182598 Pathway Wu-Stein-2010 BCL2L1 BCL2 0.018142007291316986 Pathway Wu-Stein-2010 RRM2B TP53 0.01799839735031128 Pathway Wu-Stein-2010 CCNA1 CDK2 0.017835581675171852 Pathway Wu-Stein-2010 CDKN1B CCNE2 0.01778043992817402 Pathway Wu-Stein-2010 CYCS CASP9 0.017749445512890816 Pathway Wu-Stein-2010 CASP8 BID 0.017728975042700768 Pathway Wu-Stein-2010 TP53 BAX 0.017457611858844757 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 TP53 GTSE1 0.01729932613670826 Pathway Wu-Stein-2010 CDK1 GADD45B 0.017206985503435135 Pathway Wu-Stein-2010 CDKN1A CCNE2 0.01689133234322071 Pathway Wu-Stein-2010 CDC25C CDK1 0.016875896602869034 Pathway Wu-Stein-2010 GADD45A TP53 0.01676618680357933 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 CDK4 CCNB1 0.016620595008134842 Pathway Wu-Stein-2010 TP53 RRM2 0.016597993671894073 Pathway Wu-Stein-2010 CDKN1B CDK6 0.016562607139348984 Pathway Wu-Stein-2010 CDKN1A CDK6 0.015734396874904633 Pathway Wu-Stein-2010 CASP2 CASP8 0.015725156292319298 Pathway Wu-Stein-2010 CASP3 APAF1 0.015026944689452648 Pathway Wu-Stein-2010 CCNA1 CDK1 0.014953721314668655 Pathway Wu-Stein-2010 GADD45A CDK1 0.01463249884545803 Pathway Wu-Stein-2010 CDK2 CCNB2 0.01434276718646288 Pathway Wu-Stein-2010 CDKN1B CCND2 0.014174598269164562 Pathway Wu-Stein-2010 CDKN1B CDK4 0.013481984846293926 Pathway Wu-Stein-2010 CDKN1A CCND2 0.013465800322592258 Pathway Wu-Stein-2010 BCL2L1 CYCS 0.013438518159091473 Pathway Wu-Stein-2010 MCM2 CDKN1B 0.013352974317967892 Pathway Wu-Stein-2010 TP53 CHEK1 0.013303400948643684 Pathway Wu-Stein-2010 PCNA CDKN1A 0.013166741468012333 Pathway Wu-Stein-2010 CCNB1 SFN 0.013127326965332031 Pathway Wu-Stein-2010 TP53 FAS 0.013021414633840322 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 CCND1 CCND2 0.012963720597326756 Pathway Wu-Stein-2010 CDK4 CDKN1A 0.012807820923626423 Pathway Wu-Stein-2010 MCM2 CDKN1A 0.012685260735452175 Pathway Wu-Stein-2010 PCNA CCND1 0.012675813399255276 Pathway Wu-Stein-2010 CASP3 CASP9 0.012403412722051144 Pathway Wu-Stein-2010 BCL2 CASP8 0.012223863042891026 Pathway Wu-Stein-2010 TP53 CCNB1 0.012102502398192883 Pathway PATHWAYCOMMONS-NCI_NATURE Wu-Stein-2010 CDKN1B CCNE1 0.011930174194276333 Pathway Wu-Stein-2010 CDC45 CDK2 0.011469731107354164 Pathway Wu-Stein-2010 CDKN1A CCNE1 0.011333608999848366 Pathway Wu-Stein-2010 MCM2 CDK2 0.011201244778931141 Pathway Wu-Stein-2010 TP53 GADD45G 0.010946793481707573 Pathway Wu-Stein-2010 TP53 TSC2 0.010664873756468296 Pathway PATHWAYCOMMONS-NCI_NATURE CCNA2 TP53 0.010655858553946018 Pathway Wu-Stein-2010 CDKN1B SFN 0.01064838096499443 Pathway Wu-Stein-2010

第46页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks TP53 BID 0.00978909619152546 Pathway PATHWAYCOMMONS-NCI_NATURE BCL2 CYCS 0.009373096749186516 Pathway Wu-Stein-2010 CDK2 SFN 0.008932476863265038 Pathway Wu-Stein-2010 CDKN1A CCNB1 0.008614642545580864 Pathway Wu-Stein-2010 CASP2 CASP3 0.008426088839769363 Pathway Wu-Stein-2010 TP53 GADD45B 0.008348429575562477 Pathway Wu-Stein-2010 TP53 SIAH1 0.008262681774795055 Pathway Wu-Stein-2010 CDK2 CCNB1 0.007606837898492813 Pathway Wu-Stein-2010 CDK1 SFN 0.007489173207432032 Pathway Wu-Stein-2010 CDKN1B CDKN1A 0.006987865548580885 Pathway Wu-Stein-2010 CDKN1B CCND1 0.006727319676429033 Pathway Wu-Stein-2010 TP53 THBS1 0.006418800912797451 Pathway Wu-Stein-2010 CDKN1A CCND1 0.006390921305865049 Pathway Wu-Stein-2010 CASP3 CASP8 0.006327483337372541 Pathway Wu-Stein-2010 CASP3 CYCS 0.004851830191910267 Pathway Wu-Stein-2010 BCL2L1 TP53 0.004719964228570461 Pathway Wu-Stein-2010 TP53 SFN 0.003633572719991207 Pathway Wu-Stein-2010 TP53 POLR1D 0.0035816568415611982 Pathway Wu-Stein-2010 TP53 ATR 0.003485262393951416 Pathway Wu-Stein-2010 BCL2 TP53 0.0032920800149440765 Pathway Wu-Stein-2010 TP53 PTEN 0.003254890674725175 Pathway Wu-Stein-2010 TP53 CDKN1A 0.002384486375376582 Pathway Wu-Stein-2010 TP53 CCND1 0.0022955797612667084 Pathway Wu-Stein-2010 POLR1C POLR1D 2.3327434360980988 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID IREF-INTACT Rual-Vidal-2005 A Rual-Vidal-2005 B CASP9 APAF1 1.9131536930799484 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-DIP IREF-GRID IREF-INTACT TAF1A UBTF 1.8041356280446053 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-GRID IREF-MPPI PCNA CDKN1A 1.7436729203909636 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-CORUM IREF-DIP IREF-GRID IREF-INTACT Rual-Vidal-2005 A Rual-Vidal-2005 B CYCS APAF1 1.4705346077680588 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-CORUM IREF-GRID IREF-INTACT CDK1 CCNB2 1.4030454605817795 Physical interactions Hutchins-Peters-2010 IREF-BIND IREF-CORUM IREF-DIP IREF-INTACT CDK4 CCND2 1.3997542075812817 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-CORUM IREF-DIP IREF-GRID IREF-INTACT CCND3 CDK4 1.3464093450456858 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-CORUM IREF-DIP IREF-GRID

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Gene 1 Gene 2 Weight Network group Networks IREF-INTACT Ramachandran-LaBaer-2004 Rual-Vidal-2005 A Rual-Vidal-2005 B CDKN1B CCND2 1.3312768079340458 Physical interactions IREF-GRID IREF-INTACT Rual-Vidal-2005 A Rual-Vidal-2005 B CDK4 CDKN2A 1.1499934028834105 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-DIP IREF-GRID IREF-INTACT IREF-MPPI CDK1 CCNB1 1.0885749626904726 Physical interactions BIOGRID-SMALL-SCALE-STUDIES Hutchins-Peters-2010 IREF-BIND IREF-CORUM IREF-DIP IREF-GRID IREF-INTACT CCNA2 CDK1 0.9687878824770451 Physical interactions BIOGRID-SMALL-SCALE-STUDIES Hutchins-Peters-2010 IREF-BIND IREF-CORUM IREF-DIP IREF-GRID IREF-INTACT CCND3 CDK6 0.9649940207600594 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-CORUM IREF-GRID IREF-INTACT Ramachandran-LaBaer-2004 CASP8 FAS 0.9486086051911116 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-GRID IREF-INTACT IREF-MPPI CDK2 CCNE1 0.9284755028784275 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-CORUM IREF-DIP IREF-GRID IREF-INTACT CDK2 CDKN1A 0.911811881698668 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-DIP IREF-GRID IREF-INTACT IREF-MPPI Ramachandran-LaBaer-2004 PTCH1 CCNB1 0.8921911120414734 Physical interactions IREF-BIND IREF-DIP CDKN1A CCND2 0.8616384454071522 Physical interactions IREF-GRID IREF-INTACT Rual-Vidal-2005 A Rual-Vidal-2005 B BCL2L1 CYCS 0.8087802864611149 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-GRID IREF-MPPI CDK2 CCNE2 0.7642457224428654 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-GRID IREF-INTACT Ramachandran-LaBaer-2004

第48页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks BCL2L1 BID 0.7496135924011469 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-CORUM IREF-DIP IREF-GRID IREF-INTACT CCNB3 CDK2 0.7124666124582291 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID IREF-INTACT CCND1 CDK6 0.7047988474369049 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-CORUM IREF-GRID IREF-INTACT Ramachandran-LaBaer-2004 BCL2 BID 0.7020091190934181 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-CORUM IREF-DIP IREF-GRID IREF-INTACT CCND3 CDKN1A 0.7011360935866833 Physical interactions IREF-BIND IREF-GRID IREF-INTACT Ramachandran-LaBaer-2004 Rual-Vidal-2005 A Rual-Vidal-2005 B CCNA2 CDK2 0.6511537916958332 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-CORUM IREF-DIP IREF-GRID IREF-INTACT BCL2 BAX 0.6423973413184285 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-DIP IREF-GRID IREF-INTACT IREF-MPPI CDK6 CCND2 0.6396479159593582 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-CORUM IREF-GRID CDK4 CCND1 0.6305848099291325 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-CORUM IREF-DIP IREF-GRID IREF-INTACT Ramachandran-LaBaer-2004 CDC25C CHEK1 0.6260989382863045 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID IREF-INTACT CDKN1B CCND3 0.5946294106543064 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID IREF-INTACT Rual-Vidal-2005 A Rual-Vidal-2005 B CASP2 PIDD 0.5848846808075905 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID IREF-INTACT CDK2 CCNB2 0.578129306435585 Physical interactions IREF-BIND IREF-INTACT Ramachandran-LaBaer-2004 MCM2 CCNB2 0.5197872221469879 Physical interactions IREF-BIND IREF-INTACT Ramachandran-LaBaer-2004

第49页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks CHEK1 ATR 0.4865309800952673 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-DIP IREF-GRID BAX BID 0.4758540838956833 Physical interactions IREF-BIND IREF-DIP IREF-INTACT WEE1 CDK1 0.47374802827835083 Physical interactions IREF-BIND CDKN1C CCNE2 0.4460991322994232 Physical interactions IREF-INTACT CDKN1A CCND1 0.4399053305387497 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-DIP IREF-GRID IREF-INTACT Ramachandran-LaBaer-2004 CDK6 CDKN2A 0.41358625516295433 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-DIP IREF-GRID IREF-INTACT Ramachandran-LaBaer-2004 CDKN1A CCNE1 0.399165328592062 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID IREF-INTACT CDKN1B CCNE1 0.39301856979727745 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID IREF-INTACT CCNA2 CDKN1A 0.3760218024253845 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID IREF-INTACT CCNA2 CDKN1B 0.36669300496578217 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-GRID IREF-INTACT CDKN1A CCNB2 0.3660392090678215 Physical interactions IREF-BIND IREF-INTACT Ramachandran-LaBaer-2004 CDKN1A CCNE2 0.3477895185351372 Physical interactions IREF-BIND IREF-INTACT Ramachandran-LaBaer-2004 CDK1 GADD45B 0.3340947553515434 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID CDKN1B CDK1 0.30836864560842514 Physical interactions Hutchins-Peters-2010 IREF-DIP GADD45A CCNB1 0.2978694550693035 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-GRID CDC45 CDKN2A 0.2963600978255272 Physical interactions IREF-BIND IREF-INTACT Ramachandran-LaBaer-2004 MCM2 CDK6 0.25801756978034973 Physical interactions IREF-BIND IREF-INTACT Ramachandran-LaBaer-2004 CDKN1A CDK6 0.24901373125612736 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-GRID IREF-INTACT Ramachandran-LaBaer-2004 CDC45 CDKN1A 0.24467727914452553 Physical interactions IREF-BIND IREF-INTACT Ramachandran-LaBaer-2004

第50页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks BAG1 BCL2 0.24288892559707165 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID BCL2L1 TP53 0.23993396759033203 Physical interactions IREF-BIND IREF-CORUM IREF-INTACT CDK4 CDKN1A 0.2350893560796976 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-DIP IREF-GRID IREF-INTACT Ramachandran-LaBaer-2004 BCL2L1 BAX 0.23380091227591038 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-DIP IREF-GRID IREF-INTACT GADD45A PCNA 0.2265569306910038 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-DIP IREF-GRID PCNA TCOF1 0.22397449612617493 Physical interactions IREF-BIND BCL2L1 PMAIP1 0.22315388545393944 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID IREF-INTACT CDC45 MCM2 0.21009674668312073 Physical interactions IREF-DIP CDKN1B CCND1 0.20255590975284576 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-GRID IREF-INTACT BAX PMAIP1 0.2013361006975174 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID BCL2 TP53 0.19963097758591175 Physical interactions IREF-CORUM IREF-DIP CCNA1 CDKN1A 0.1991000408306718 Physical interactions IREF-BIND IREF-INTACT Ramachandran-LaBaer-2004 CCNA1 CDKN1B 0.19620651192963123 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-DIP IREF-GRID IREF-INTACT CDKN1C CCNA2 0.19496069848537445 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID MCM2 CDK4 0.18947810865938663 Physical interactions IREF-BIND IREF-INTACT Ramachandran-LaBaer-2004 CASP3 BID 0.18839479610323906 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID CDC45 CDK4 0.18440397083759308 Physical interactions Ramachandran-LaBaer-2004 CDKN2A CCNG1 0.18096262961626053 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID GADD45A GADD45B 0.1788327544927597 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID PCNA GADD45G 0.16855199448764324 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-DIP IREF-GRID GADD45A GADD45G 0.16586360335350037 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CDC25C CDK1 0.1615777388215065 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID IREF-INTACT

第51页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks GADD45A CDK1 0.15880993008613586 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID CDK1 GADD45G 0.15816914662718773 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID CDKN1C CCND1 0.14895715564489365 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID MCM2 CDKN2A 0.14491572976112366 Physical interactions IREF-BIND IREF-INTACT Ramachandran-LaBaer-2004 CCNB1 GADD45G 0.14490248635411263 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-GRID PCNA GADD45B 0.14107878133654594 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-GRID CDKN1C CDK4 0.1308305859565735 Physical interactions IREF-INTACT TSC2 CCND2 0.1267087608575821 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CDK1 CCNE1 0.12489032000303268 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID CDKN1B CDK4 0.12014089711010456 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID IREF-INTACT TP53 RRM2 0.11615771986544132 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID CDKN2A CCND2 0.11592807248234749 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CDC25C CCNB1 0.11560679972171783 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CASP2 BID 0.11558174714446068 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CCNB1 GADD45B 0.11423828825354576 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CASP3 CASP9 0.11411387473344803 Physical interactions IREF-DIP CDKN1B CDK2 0.11387356091290712 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-GRID IREF-INTACT PCNA CCNA2 0.11027215793728828 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID CASP2 CCND3 0.1081097312271595 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID BCL2L1 BCL2 0.09997257683426142 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID IREF-INTACT CDKN1A CCNB1 0.0891107115894556 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-GRID BAG1 SIAH1 0.08732651546597481 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CASP3 CASP8 0.08602562732994556 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID CDKN1B CDK6 0.08468896895647049 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID BCL2 PMAIP1 0.08445052430033684 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID

第52页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks CDK2 CCND1 0.08142349123954773 Physical interactions IREF-DIP IREF-INTACT CCNA1 MCM2 0.08074772916734219 Physical interactions IREF-DIP IREF-INTACT CDKN1B CCNB1 0.08040127158164978 Physical interactions IREF-INTACT CDK2 CCND2 0.07772931456565857 Physical interactions IREF-INTACT CCND3 TSC2 0.07565345615148544 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID FAS BID 0.0739133395254612 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CDK1 CDKN1A 0.07317987270653248 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-GRID TP53 ATR 0.07214876729995012 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-BIND IREF-GRID IREF-INTACT BCL2L1 APAF1 0.07129235193133354 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CASP8 APAF1 0.07031477242708206 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID GADD45A CDKN1A 0.07017505913972855 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID RRM2B TP53 0.06968426331877708 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID CDKN1A GADD45G 0.06937782652676105 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CASP2 CASP3 0.06911372765898705 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID TP53 SFN 0.06876587797887623 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID CDKN1C PCNA 0.06349616684019566 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CDKN1B CCNE2 0.06251993030309677 Physical interactions IREF-INTACT CCND1 TSC2 0.05750369839370251 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CCNA1 CDK1 0.056308189406991005 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID IREF-INTACT CASP2 CASP9 0.05607973039150238 Physical interactions IREF-GRID CDK1 CCND1 0.05584840103983879 Physical interactions IREF-DIP CDKN1B TSC2 0.05481605976819992 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CASP2 CASP8 0.054321300238370895 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID BCL2L1 CASP9 0.053250811994075775 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CCND1 CDKN2A 0.05297212116420269 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CASP8 CASP9 0.0526503250002861 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CASP8 BID 0.050824809819459915 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID BCL2 CASP8 0.04974389914423227 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID IREF-INTACT CDKN1A CHEK1 0.049138106405735016 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CDK2 CDK6 0.04568631760776043 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CDC25C PCNA 0.044184381142258644 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID

第53页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks WEE1 SFN 0.04207173362374306 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID PCNA CDKN2A 0.03886319324374199 Physical interactions IREF-INTACT TP73 CCNG1 0.03873297944664955 Physical interactions BIOGRID-SMALL-SCALE-STUDIES CCNA1 CDK2 0.037676031701266766 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID IREF-INTACT TP53 CDKN2A 0.03654328407719731 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID IREF-INTACT MCM2 ATR 0.032300377264618874 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CDK2 CCNB1 0.031344388611614704 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID PCNA CCND3 0.030429769307374954 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID TP53 CCNG1 0.030405625700950623 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CASP2 BCL2L1 0.026513224467635155 Physical interactions IREF-GRID PCNA CDK2 0.025527595076709986 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID PCNA CDK4 0.024077332578599453 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID PCNA CCND1 0.02343119401484728 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID BCL2 CASP3 0.02249008510261774 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CASP2 BCL2 0.019442470744252205 Physical interactions IREF-GRID CHEK1 SFN 0.018368412740528584 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID BCL2 CDK1 0.017652077600359917 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID TAF1A TP53 0.017525780014693737 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID TP53 CDK1 0.01641748659312725 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-DIP IREF-GRID TP53 PTEN 0.015107700135558844 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID PCNA CHEK1 0.012746219523251057 Physical interactions BIOGRID-SMALL-SCALE-STUDIES BCL2L1 CASP8 0.01178227923810482 Physical interactions IREF-GRID CCNA2 TP53 0.011638988740742207 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID TP53 CHEK1 0.010835440829396248 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID CDK1 SFN 0.00995879853144288 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID BAG1 TP53 0.008012227714061737 Physical interactions IREF-GRID TP53 CDKN1A 0.006549217505380511 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID TP53 CDK2 0.0045933404471725225 Physical interactions BIOGRID-SMALL-SCALE-STUDIES IREF-GRID TP53 TSC2 0.004562865011394024 Physical interactions IREF-GRID POLR1C POLR1D 3.870313359424472 Predicted I2D-BIND-Fly2Human I2D-BIND-Yeast2Human I2D-Giot-Rothbert-2003-High- Fly2Human I2D-Tarassov-PCA-Yeast2Human I2D-Yu-Vidal-2008-GoldStd- Yeast2Human Stuart-Kim-2003

第54页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks CDK1 CCNB1 2.4144457085058093 Predicted I2D-BIND-Mouse2Human I2D-BioGRID-Mouse2Human I2D-INNATEDB-Mouse2Human I2D-IntAct-Mouse2Human Stuart-Kim-2003 CDK2 CDKN1A 1.8903128951787949 Predicted I2D-BIND-Mouse2Human I2D-BioGRID-Mouse2Human I2D-INNATEDB-Mouse2Human I2D-MGI-Mouse2Human CASP9 APAF1 1.0 Predicted I2D-MINT-Rat2Human CDK4 CCND1 0.9310891181230545 Predicted I2D-BIND-Mouse2Human I2D-IntAct-Mouse2Human I2D-MGI-Mouse2Human BCL2 BID 0.9166815876960754 Predicted I2D-BIND-Mouse2Human I2D-IntAct-Mouse2Human CDK2 CCNE1 0.9012262225151062 Predicted I2D-IntAct-Mouse2Human I2D-MGI-Mouse2Human CDKN1A GADD45G 0.8312538862228394 Predicted I2D-IntAct-Mouse2Human CDK1 CCNE1 0.8296301662921906 Predicted I2D-BIND-Mouse2Human I2D-IntAct-Mouse2Human Stuart-Kim-2003 CDC25C CDK1 0.8289100602269173 Predicted I2D-BIND-Fly2Human I2D-IntAct-Mouse2Human Stuart-Kim-2003 BCL2 BAX 0.8256261199712753 Predicted I2D-BIND-Mouse2Human I2D-MGI-Mouse2Human PTCH1 CCNB1 0.8164966106414795 Predicted I2D-BIND-Mouse2Human CDK4 CDKN1A 0.7662309110164642 Predicted I2D-BioGRID-Mouse2Human I2D-MGI-Mouse2Human CDC45 MCM2 0.6689056130126119 Predicted I2D-BIND-Fly2Human Stuart-Kim-2003 PCNA GADD45G 0.66046342253685 Predicted I2D-IntAct-Mouse2Human I2D-MGI-Mouse2Human CCNA2 CDK2 0.6376998424530029 Predicted I2D-BIND-Mouse2Human I2D-IntAct-Mouse2Human CCNA2 CDK1 0.5829493999481201 Predicted I2D-BIND-Mouse2Human I2D-IntAct-Mouse2Human CDKN1B CCND2 0.5714221596717834 Predicted I2D-MGI-Mouse2Human CDK2 CCND1 0.47507836669683456 Predicted I2D-BIND-Mouse2Human I2D-IntAct-Mouse2Human CDKN1A CCND1 0.47319795191287994 Predicted I2D-BioGRID-Mouse2Human I2D-MGI-Mouse2Human CDK1 CCNB2 0.4445926947519183 Predicted I2D-IntAct-Mouse2Human Stuart-Kim-2003 CDK2 CCNE2 0.42376938462257385 Predicted I2D-IntAct-Mouse2Human CCNB3 CDK2 0.42376938462257385 Predicted I2D-IntAct-Mouse2Human CDKN1B CCND1 0.39280757308006287 Predicted I2D-IntAct-Mouse2Human I2D-MGI-Mouse2Human CCND3 CCND2 0.3854333460330963 Predicted I2D-IntAct-Mouse2Human TP53 TP73 0.34491419792175293 Predicted I2D-BIND-Mouse2Human CDKN1B CCND3 0.3397696614265442 Predicted I2D-MGI-Mouse2Human CDK4 CCND2 0.31140854954719543 Predicted I2D-IntAct-Mouse2Human CDKN1B CDK4 0.3114003837108612 Predicted I2D-IntAct-Mouse2Human I2D-MGI-Mouse2Human TP53 SFN 0.30797186493873596 Predicted I2D-INNATEDB-Mouse2Human CDKN1B CDK2 0.30632393062114716 Predicted I2D-IntAct-Mouse2Human I2D-MGI-Mouse2Human BCL2L1 BID 0.3006100654602051 Predicted I2D-IntAct-Mouse2Human CCNA1 CDK1 0.29403216764330864 Predicted I2D-IntAct-Mouse2Human Stuart-Kim-2003 CCNB1 GADD45B 0.27920079231262207 Predicted I2D-MGI-Mouse2Human CCNB1 GADD45G 0.27920079231262207 Predicted I2D-MGI-Mouse2Human GADD45A CCNB1 0.27920079231262207 Predicted I2D-MGI-Mouse2Human

第55页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks PCNA GADD45B 0.26860058307647705 Predicted I2D-MGI-Mouse2Human GADD45A PCNA 0.26860058307647705 Predicted I2D-MGI-Mouse2Human CCND1 CDK6 0.2676272392272949 Predicted I2D-IntAct-Mouse2Human CCNA1 CDK2 0.24773484468460083 Predicted I2D-IntAct-Mouse2Human CASP8 FAS 0.2414245456457138 Predicted I2D-IntAct-Mouse2Human CDKN1B TSC2 0.23253761231899261 Predicted I2D-INNATEDB-Mouse2Human CCND3 CDK6 0.22812671959400177 Predicted I2D-IntAct-Mouse2Human CDK1 GADD45B 0.20398032665252686 Predicted I2D-MGI-Mouse2Human CDK1 GADD45G 0.20398032665252686 Predicted I2D-MGI-Mouse2Human GADD45A CDK1 0.20398032665252686 Predicted I2D-MGI-Mouse2Human BCL2L1 BAX 0.19520340859889984 Predicted I2D-BIND-Mouse2Human PCNA CDK2 0.19017603993415833 Predicted I2D-MGI-Mouse2Human CDK4 CDK6 0.1843135952949524 Predicted I2D-IntAct-Mouse2Human TP53 CCNG1 0.16988112032413483 Predicted I2D-BIND-Mouse2Human BCL2L1 TP53 0.16000071913003922 Predicted I2D-BIND-Mouse2Human I2D-IntAct-Mouse2Human PCNA CDK4 0.1532798558473587 Predicted I2D-MGI-Mouse2Human CDK2 CDK6 0.14143483340740204 Predicted I2D-IntAct-Mouse2Human CCND3 CDK4 0.13345502316951752 Predicted I2D-IntAct-Mouse2Human CDK1 CDKN1A 0.1329687088727951 Predicted I2D-MGI-Mouse2Human CCNA1 CCNE1 0.08765628933906555 Predicted Stuart-Kim-2003 CCNA1 CDC25C 0.0430615060031414 Predicted Stuart-Kim-2003 CCNA1 CCNB2 0.04028606414794922 Predicted Stuart-Kim-2003 CCNA1 CCNB1 0.04028606414794922 Predicted Stuart-Kim-2003 RRM2 CCNE1 0.03876112401485443 Predicted Stuart-Kim-2003 CDK1 CCNG2 0.03643348440527916 Predicted I2D-BIND-Fly2Human CCNB2 CCNE1 0.03342698886990547 Predicted Stuart-Kim-2003 CCNB1 CCNE1 0.03342698886990547 Predicted Stuart-Kim-2003 MCM2 CCNE1 0.02607402577996254 Predicted Stuart-Kim-2003 PTCH1 SIAH1 0.02120194397866726 Predicted I2D-BIND-Fly2Human CCNB2 RRM2 0.0178142748773098 Predicted Stuart-Kim-2003 CCNB1 RRM2 0.0178142748773098 Predicted Stuart-Kim-2003 PCNA RRM2 0.01770211197435856 Predicted Stuart-Kim-2003 CDC45 RRM2 0.017599664628505707 Predicted Stuart-Kim-2003 CDC25C CCNB2 0.01642114482820034 Predicted Stuart-Kim-2003 CDC25C CCNB1 0.01642114482820034 Predicted Stuart-Kim-2003 CDC45 CDC25C 0.016223318874835968 Predicted Stuart-Kim-2003 CDC45 PCNA 0.015082115307450294 Predicted Stuart-Kim-2003 CDK1 RRM2 0.014539308845996857 Predicted Stuart-Kim-2003 MCM2 RRM2 0.013895652256906033 Predicted Stuart-Kim-2003 MCM2 CDC25C 0.012808969244360924 Predicted Stuart-Kim-2003 PCNA CDK1 0.01245952770113945 Predicted Stuart-Kim-2003 MCM2 CCNB2 0.011983394622802734 Predicted Stuart-Kim-2003 MCM2 CCNB1 0.011983394622802734 Predicted Stuart-Kim-2003 MCM2 CDK1 0.00978037342429161 Predicted Stuart-Kim-2003 RRM2B RRM2 2.0 Shared protein domains INTERPRO PFAM SESN2 SESN3 1.0 Shared protein domains INTERPRO PFAM CDKN1B CDKN1A 1.0 Shared protein domains INTERPRO PFAM SESN1 SESN3 1.0 Shared protein domains INTERPRO PFAM SESN1 SESN2 1.0 Shared protein domains INTERPRO PFAM CDKN1C CDKN1A 1.0 Shared protein domains INTERPRO PFAM CDKN1C CDKN1B 1.0 Shared protein domains INTERPRO PFAM

第56页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks TP53 TP73 0.6849730610847473 Shared protein domains INTERPRO PFAM BCL2L1 BCL2 0.38098789751529694 Shared protein domains INTERPRO PFAM POLR1C POLR1D 0.3599122613668442 Shared protein domains INTERPRO PFAM GADD45G GADD45B 0.20461415499448776 Shared protein domains INTERPRO PFAM GADD45A GADD45B 0.20461415499448776 Shared protein domains INTERPRO PFAM GADD45A GADD45G 0.20461415499448776 Shared protein domains INTERPRO PFAM BCL2L1 BAX 0.1728036180138588 Shared protein domains INTERPRO PFAM BCL2 BAX 0.17280344665050507 Shared protein domains INTERPRO PFAM CASP3 CASP8 0.13665896654129028 Shared protein domains INTERPRO PFAM CASP3 CASP9 0.10665703564882278 Shared protein domains INTERPRO PFAM CASP2 CASP3 0.10665703564882278 Shared protein domains INTERPRO PFAM CASP2 CASP9 0.10556208714842796 Shared protein domains INTERPRO PFAM CASP8 CASP9 0.08244907110929489 Shared protein domains INTERPRO PFAM CASP2 CASP8 0.08244907110929489 Shared protein domains INTERPRO PFAM CCNE2 CCNE1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCND2 CCNE1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCND2 CCNE2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNB2 CCNE1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNB2 CCNE2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNB2 CCND2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNB1 CCNE1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNB1 CCNE2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNB1 CCND2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNB1 CCNB2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCND1 CCNE1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCND1 CCNE2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCND1 CCND2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCND1 CCNB2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCND1 CCNB1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCND3 CCNE1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCND3 CCNE2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCND3 CCND2 0.08090760186314583 Shared protein domains INTERPRO PFAM

第57页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks CCND3 CCNB2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCND3 CCNB1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCND3 CCND1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNA2 CCNE1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNA2 CCNE2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNA2 CCND2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNA2 CCNB2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNA2 CCNB1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNA2 CCND1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNA2 CCND3 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNB3 CCNE1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNB3 CCNE2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNB3 CCND2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNB3 CCNB2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNB3 CCNB1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNB3 CCND1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNB3 CCND3 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNB3 CCNA2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNA1 CCNE1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNA1 CCNE2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNA1 CCND2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNA1 CCNB2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNA1 CCNB1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNA1 CCND1 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNA1 CCND3 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNA1 CCNA2 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNA1 CCNB3 0.08090760186314583 Shared protein domains INTERPRO PFAM CCNG1 CCNG2 0.0625481829047203 Shared protein domains INTERPRO PFAM CCNE1 CCNG2 0.04677370376884937 Shared protein domains INTERPRO PFAM CCNE1 CCNG1 0.04677370376884937 Shared protein domains INTERPRO PFAM CCNE2 CCNG2 0.04677370376884937 Shared protein domains INTERPRO PFAM CCNE2 CCNG1 0.04677370376884937 Shared protein domains INTERPRO PFAM

第58页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks CCND2 CCNG2 0.04677370376884937 Shared protein domains INTERPRO PFAM CCND2 CCNG1 0.04677370376884937 Shared protein domains INTERPRO PFAM CCNB2 CCNG2 0.04677370376884937 Shared protein domains INTERPRO PFAM CCNB2 CCNG1 0.04677370376884937 Shared protein domains INTERPRO PFAM CCNB1 CCNG2 0.04677370376884937 Shared protein domains INTERPRO PFAM CCNB1 CCNG1 0.04677370376884937 Shared protein domains INTERPRO PFAM CCND1 CCNG2 0.04677370376884937 Shared protein domains INTERPRO PFAM CCND1 CCNG1 0.04677370376884937 Shared protein domains INTERPRO PFAM CCND3 CCNG2 0.04677370376884937 Shared protein domains INTERPRO PFAM CCND3 CCNG1 0.04677370376884937 Shared protein domains INTERPRO PFAM CCNA2 CCNG2 0.04677370376884937 Shared protein domains INTERPRO PFAM CCNA2 CCNG1 0.04677370376884937 Shared protein domains INTERPRO PFAM CCNB3 CCNG2 0.04677370376884937 Shared protein domains INTERPRO PFAM CCNB3 CCNG1 0.04677370376884937 Shared protein domains INTERPRO PFAM CCNA1 CCNG2 0.04677370376884937 Shared protein domains INTERPRO PFAM CCNA1 CCNG1 0.04677370376884937 Shared protein domains INTERPRO PFAM FAS PIDD 0.02365601621568203 Shared protein domains INTERPRO PFAM CASP9 APAF1 0.020499895326793194 Shared protein domains INTERPRO PFAM CASP2 APAF1 0.020499895326793194 Shared protein domains INTERPRO PFAM CDK4 CHEK1 0.008801890537142754 Shared protein domains INTERPRO PFAM CDK4 CDK6 0.0073200734332203865 Shared protein domains INTERPRO PFAM CDK4 CDK2 0.0073200734332203865 Shared protein domains INTERPRO PFAM CDK1 CDK4 0.0073200734332203865 Shared protein domains INTERPRO PFAM WEE1 CDK6 0.007237821584567428 Shared protein domains INTERPRO PFAM WEE1 CDK2 0.007237821584567428 Shared protein domains INTERPRO PFAM WEE1 CDK1 0.007237821584567428 Shared protein domains INTERPRO PFAM WEE1 CHEK1 0.006461191922426224 Shared protein domains INTERPRO PFAM CDK2 CDK6 0.004695078823715448 Shared protein domains INTERPRO PFAM CDK1 CDK6 0.004695078823715448 Shared protein domains INTERPRO PFAM CDK1 CDK2 0.004695078823715448 Shared protein domains INTERPRO PFAM CHEK1 CDK6 0.00412518554367125 Shared protein domains INTERPRO PFAM CDK2 CHEK1 0.00412518554367125 Shared protein domains INTERPRO PFAM

第59页共60页 2012/12/5 14:07 GeneMANIA http://www.genemania.org/print

Gene 1 Gene 2 Weight Network group Networks CDK1 CHEK1 0.00412518554367125 Shared protein domains INTERPRO PFAM WEE1 CDK4 0.003315778449177742 Shared protein domains PFAM

Search results generated by the GeneMANIA algorithm (genemania.org)

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