Start in Kobe. Innovate in Kobe. KOBE Biomedical Innovation Cluster Business Launch Support Guide Foundation for KOBE Biomedical Innovation Cluster Biomedical Research and Innovation at Kobe (FBRI) The City of Kobe launched the Kobe Biomedical Innovation Cluster (KBIC) as a recovery project to rebuild the As a core support organization of Kobe Biomedical Innovation Center, FBRI aims to create economy of Kobe, which was severely damaged by the Great Hanshin-Awaji Earthquake that occurred on January 17, groundbreaking medical technologies and innovations by promoting collaboration and integration 1995. Since 1998, the City of Kobe has developed an R&D hub for advanced medical technology on Port Island, an among industries, universities and the governmental and life science sectors, to become Asia’s artificial island, and through collaboration among industries, universities and the governmental and medical sectors, it leading biomedical cluster. Dr. Tasuku Honjo, President has built up a cluster of medical-related industries that will be the growth engine for the life sciences industry in the 21st century. To date, it has grown to become Japan's largest biomedical cluster with a concentration of about 370 Organizations cutting-edge research institutes, highly specialized hospitals, medical-related companies and universities. Institute of Biomedical Translational Research Research and Center for Cluster Research and Center for Medical Development Center Development and Innovation(IBRI) Innovation(TRI) for Cell Therapy (RDC) Coordination (CCD) Creation of new medical seeds with Support for the development of Global standardization of regenera- Providing one-stop services to respond a focus on "immunology R&D," new medical seeds in Japan and tive medicine from Kobe through to a wide range of support needs in a "R&D, for the aging" and "regenera- overseas, with a focus on the the development of a next-genera- centralized manner, from the identifica- tive medicine R&D” research and development seeds tion cell cultivation systems, etc. tion of seeds to intellectual property, Clusters Aimed at Creating Innovation of FBRI pharmaceutical consultations, and sales channel development A concentration of about 370 companies and organizations Business Incubation and Research Division Practical Application Promotion Division Collaboration Liaison Office ● Research institutes, hospitals, and companies are concentrated in a compact area, creating a variety of innovations through collaboration ● A concentration of contract research organizations, contract testing organizations, CROs, CMOs, and animal breeding and experimentation facilities to respond to a variety of research and development needs ● The Translational Research Informatics Center (TRI) supports clinical research and collaborates with nine highly specialized hospital clusters to create an environment conducive to clinical research

Full support system Companies/organizations: 369 (Feb. 2020) ● Expanding support for startups by providing, among others, various incubation facilities and acceleration programs Company and Organization Number of employees: About 11,000 (Mar. 2019) ● Kobe City staff, together with dedicated coordinators, provide support for the commercialization for expanding businesses and support for individual company matching Shift in employee numbers Breakdown of companies/ ● PMDA Pharmaceutical Affairs Strategic Consultation is available for company and organization organizations As of end of Feb. 2020 12000 400 352 11000 IT & software Clinical 5.1% 336 350 Logistics Medical institutions Basic Research Institutions 10000 Number of employees 2.2% 2.7% Number of companies/ 9000 organizations 300 271 Other 8000 7.6% Research Hospitals 250 institutes 7000 Medical devices 203 27.1% INNOVATION 6000 200 R&D support 5000 16.3% Foundation for Biomedical Kobe City 150 Pharmaceutical / Research and Innovation (FBRI) Medical Center General Hospital 4000 125 Biotechnology Institute of Biomedical Research 15.2% and Innovation (IBRI) 3000 100 Kobe City Eye Hospital 73 Translational Research Center for Universities & Medical Innovation (TRI) 2000 10,000 Industrialization 11,000 Academic groups 4,300 2,200 1,600 ,00 7,50 50 Research & Development Center for Kobe Proton Center 3.5% Cell Therapy (RDC) 1000 18 Regenerative 200 Nursing care & Healthcare medicine Nishi Memorial 0 0 rehabilitation 7.6% RIKEN Port Island Rehabilitation Hospital 2001 2004 2007 2010 2013 2016 2018 4.1% 8.7% RIKEN Center for Companies Biosystems Dynamics Research (BDR) International Clinical Cancer RIKEN Center for Research Center List of foreign companies Computational Science (R-CCS) United States Germany Pharmaceutical and Biomedical Child Chemo House Nihon Medi-Physics, Bay Biosciences, Johnson & Johnson, Nippon Boehringer Ingelheim, Kobe University Progenicyte Japan, Zimmer Biomet, Simco Japan, Siemens Japan, IQVIA Services Japan, Double Helix International Bayer Yakuhin, Dürr Dental Japan University of Hyogo Regenerative medicine Kobe Minimally Invasive Cancer Center Konan University Medical devices Italy China Belgium Korea Kobe Gakuin University Hyogo Prefectural Copan Japan BGI Japan IBP Technologies Dexcowin Japan Kobe Children’s Hospital Hyogo University of Health Sciences Nursing care and welfare Switzerland United Kingdom Kobe Women’s University / SKANJAPAN, Electrosuisse Japan, Fischer Connectors Spectris, Freeman Technology Kobe Women’s Junior College Healthcare Anshin Hospital

1 2 Enhanced Business Environment ～Initiatives at KBIC to support commercialization～ Business Support for KBIC Companies and Organizations Platform to 45 examples of 4 programs Promote Medical commercialization Drug Discovery implemented Device Commercialization Innovation Program One-stop service ● Support for development projects (accompanied or spot consultations) Supporting one-stop drug discovery and development by coordinating the ● Medical device business seminars researchers, surrounding facilities and clinical environment necessary for A dedicated coordinator serves as a guide to provide ● Study sessions about pharma and device laws, and more drug development. comprehensive support for the market research, R&D, pharmaceutical affairs, and developing sales channels Promoting Development/Introduction Healthcare Service of Nursing and Development Unfamiliar with Medical Robots Support Support Business the rules because with various 2,283 ● Cooperation with nursing care facilities ● Advice on development and improvement no connections in the Accompanied support by dedicated coordinators options citizen supporters ▲ ▲ ▲ Development subsidies for nursing/medical robots Matching companies and researchers medical community Insufficient Pharmaceutical Medical devices Healthcare ● ● (as of Feb. 2020) knowledge about ▲ Startups ▲ International expansion ● Comprehensive support desk for nursing/medical robots ● Healthcare citizen support system No marketing pharma regulations ▲ Industry-university cooperation capability at clinical environment Kobe Recruiting new members! Industrial Use of the Research Complex Program Supercomputer (Fugaku, FOCUS) KBIC Liaison Office The aim is to create a healthcare ecosystem in Kobe by gathering healthcare Achieving simulation of innovative medical technology by promoting spread Consulting party Dedicated coordinators offer consultations about, among other things, seeds and needs from across the country with a focus on the "Health Function" companies / of large-scale, high-accuracy analysis and technology advancement. organizations the practical application and commercialization of your R&D seeds. and "Data HUB" projects, and supporting companies’ commercialization through joint creation among industry-university-government-funded projects. ▲ New participating companies ▲ Medical device-related companies Research Hospital ▲ Market Bioresource Center, Pharma & regeneration medicine-related research Accompanied consultation starts! Kobe University International Clinical companies Cancer Research Center (ICCRC) Kobe University Hospital ▲ Seeds & needs Clinicians & researchers As a place for joint research between medical professionals and matching Creates evidence for the development of therapeutics, diagnostics and companies/researchers, this research base can be used as a base for medical devices through the use of bioresources (human specimens developing new medical devices by both large companies and start-up companies. +clinical information).

Cooperation/ Business Support for Startups consultation desk with medical institutions Provide optimal support for your startup needs. A consultation/cooperation desk for companies, research institutes, and Concept universities for collaboration with medical institutions located at KBIC. design Consultations about clinical trials, clinical research and joint R&D. Focused support the early stages Experts, including patent lawyers Seed Early Expansion Later Development Clinicians & researchers & Testing PMDA Strategic Consultation & Cooperation Center ・Regulatory science strategic consultation by PMDA staff Accompanied coordinators provide necessary support

2017 8 Drug 201 Conduct comprehensive regulatory science consultation 9 201 ・ approval ・Pre-consultation handling of various issues and topics Acceleration program KOBE Medtech Grand Prix KOBE application

PMDA staff People Lab Money Human Resources Activity Base Subsidies Sales Development ● Incubation Lab (CLIK, 2nd Fl.) ● Kobe Life Science Gap Fund Real-time PCR, all-in-one fluorescence microscope, che- Up to ¥5 million/per matter ● miluminescence and fluorescent imaging equipment, auto- Global drug discovery and (100% subsidy) development workshop matic cell counters, and other basic facilities and equipment are available. ● Networking ● HR management ● CoLaborator Kobe Manufacture development business Incubation labs operated by Bayer Yakuhin, Ltd., a global Introduction of VCs and drug discovery company. financial institutions

3 4 Subsidies and Grants for Expansion Incentives Various support systems are available

For large scale Office Rent Subsidy System Expanding Business Network ・3-year subsidy for 25% of office rent *1,500m2+ years, (limit: 1,500m2/¥10 million per year) ・Employee subsidy of up to ¥1.2 million/per person (maximum ¥100 million) *Subsidy eligibility: office relocation or set up with 5+ regular employees, and other requirements In addition to field-specific study sessions, we promote business matching through field-specific cluster exchange meetings where researchers and companies present their work Sample calculation For small scale Subsidy Cluster Networking Events ¥47,250 Saves Create opportunities connected to matching for business Office and Lab Rent Subsidy System Monthly Rent card/information exchanges among companies/research 3-year rent subsidy up to 50% Actual ¥1,701,000 2 ¥138,600 institutes, etc. and those from other industries (Maximum amount: ¥1,500 /m , ¥2 million/ per year) monthly rent in 3 years! * Does not apply to large companies ¥91,350 53 member companies (as of Feb. 2020) If renting a 31.5m2 lab at Kobe Medical Device Development Center (taxes excluded) Regenerative Medicine Study Group Support System for Foreign and Foreign-affiliated Companies Promote the commercialization of regenerative medicine by 3-year rent subsidy up to 25%, *5-years for 1500m2+ (Maximum amount: ¥1,500/m2, ¥10,000,000/per year) Kobe City ・ collecting and exchanging the latest information in this field and ・Subsidy of up to ¥1.2 million /per employee (maximum ¥100 million) *Requirement of 5+ regular employees information exchanges and networking among companies Hyogo ・3-year rent subsidy up to 25% Prefecture (Maximum amount: ¥750/m2, ¥1,000,000/per year *For 11+ regular employees, 1,500/m2, ¥10,000,000/per year) 28 member companies (as of Feb. 2020) Drug Discovery Forum Through information exchanges and networking among drug Startup Subsidy System discovery companies, we aim to deepen mutual understanding ・Eligibility: Startups setting up a business in the city about drug discovery-related technologies and realize new drugs 3- year subsidy up to ¥12 million for office rent, office maintenance expenses, telecommunication fees, and HR costs developed in Kobe ・ Medical Environment Innovation Program In collaboration with local hospitals, etc., we aim to create Building Acquisition Subsidy System (as of Mar. 31, 2020) medical devices originating in Kobe by matching corporate seeds ・Up to 4% of building acquisition costs (maximum amount: 20% of current taxes) with clinical needs ・Employment subsidy (¥200,000/per person) (maximum amount: 20% of current taxes) * Subsidy conditions: Increase of regular employees by 5+ (for SMEs, 2+), *Above subsidies cannot be used together (selection required)

Condominium Price Discount System ・Up to 35-50% discount depending on site, investment amount, number of employees and greening rate * Other tax incentives are also available. Joint Participation in Domestic and International Exhibitions

Create opportunities to develop and expand sales channels R&D Grants and Subsidies

(1) Joint research and joint enterprise structures Up to Regenerative Medicine and KBIC ¥10 million Pharmaceutical Biotechnology & Med-bio R&D grant ● PharmaLab Expo ● BioJapan (2) Young researcher support program Up to ¥2.5 million ● Regenerative Medicine Expo ● Congress of the Japanese Society for Regenerative Medicine

Medical Devices ● MedtecJapan ● MEDICA ● MEDICAL FAIR ASIA/THAILAND Support for HR Recruitment

Nursing & Medical Robots/Healthcare HR ecosystem business ● International Home Care & Rehabilitation Exhibition Supporting corporate recruitment activities by disseminating information to job seekers, exchanging ● Next-Generation Nursing Care Technology Expo (Tokyo Care Week) information among companies & organizations, and holding events.

5 6 ポートアイランド Central Area of Kobe 病院Biomedical Innovation Cluster List of Rental Offices

神戸女子短期大学 BioResource center established in 2019 兵庫医療大学 Shared use Private room Parking Meeting To Sannomiya rooms ↑ Facilities of Use： O ＝Office L ＝Lab M ＝machines S ＝for SOHO P ＝available R ＝ Naka Futo Sta. Futo Naka available

Kobe Chamber of Commerce and Industry ASICS TOA International Clinical Creative Lab for Kobe Center for Wet lab available for 12 Cancer Research Center (ICCRC) WDB 1 Innovation in Kobe (CLIK) 2 Medical Innovation (KCMI) CPC installation Shimin Sta. Hiroba NOEVIR WORLD FUJICCO 8 WORLD P R Hyogo Kobe Minimally Invasive International House WORLD Cancer Center WORLD Memorial Hall NEW Hyogo Prefectural Kobe Children’s Hospital Kobe Convention Kobe Portopia Hotel Center Portopia Hall

Nishi Memorial Port island Minami Koen Sta. Rehabilitation Hospital P R Minami Koen L M Kobe Minimally Invasive Park Scheduled to open Monthly rent (without tax) Cancer Center L in fall of 2020 Under Lab: ¥3,600/m , CPC: ¥4,200/m , Maintenance fee: ¥1,000/m consideration Nishi-Kinen Port island Child Kobe Proton Anshin Hospital Rehabilitation Hospital Chemo Center Shimizu Pharmacy House Shimin Byoin Kobe Medical Device Kobe Healthcare Industry Kobe Incubation Office Kobe International Kobe City Medical Center Mae building Central Hyogo Prefectural Development Center Development Center General Hospital Kobe City Medical Center green Kobe Children’s Hospital Business Center (KIBC) area 3 4 5 (KIO) 6 General Hospital 9 13 (MEDDEC) (HI-DEC) IMDA IMP DSP Yoshino Gypsum Nissei Kobe City Eye Research P R R P R P R Adjuvant Cosme Technology Hospital ICCRC SUZU GA Xrossing Kobe Proton Center

Iryo Center Sta. Center Iryo KEN Seishin Trading JFFIC KSM 16 BMA Kobe University Incubation Center Towa The Suzuki Menthol 10 Pharmaceutical TRI TAKIGEN Air Water Anshin Hospital Kobe City Eye Hospital Sawamura P&O Yasojima Proceed BDR IBRI KIMEC OK Kobe Star Plastic OYAMA 7 LEX Bio Robotix HI-DEC Translational Research Center With Monthly rent (without tax) Monthly rent Monthly rent KIBC Kan Research Institute 4 for Medical Innovation (TRI) animal testing lab L M Lab: ¥4,400/m L (without tax) O S (without tax) O L S Miyano Nichiden- Maintenance fee included Medical Rika Glass 6 BDR Monthly rent (without tax) Office: ¥2,200 – 3,300 /m Office: ¥3,200 /m Instruments Lab: ¥4,400/m Operation rooms Maintenance fee: ¥600 /m Lab: ¥2,300 – 2,500/m Nihon IIB KHBC 15 5 Maintenance fee Maintenance fee: ¥800 /m Medi-Physics Animal testing- Institute of Biomedical Research NARD KIO included facilities and Innovation(IBRI ) BANDO Boehringer Ingelheim MORESCO RF FUKUDA Mokuda KiSCO Ophtecs SHINYEI Kaisha Dental SENJU Kobe KIMEC Center Kobe International International Medical Business Support Center Minato Pharmaceutical Dürr Dental Japan Conference Center Device Alliance for Biomedical Research Medical Medical Creative Lab for Innovation 7 Building (KIMEC) 8 (PI first stage) 9 (IMDA) 10 Activities (BMA) TMS Foods Science in Kobe (CLIK) Corporation Harmony Enomoto Sanshodo scheduled to open in fall of 2020 Yakuhin 1 R R R Wakenyaku RIKEN Center for Biosystems P P P P RIKEN Center for Biosystems TOCALO 2 Kobe Center for Medical Innovation Dynamics Research (BDR) Bay bioscience Kanae (KCMI) Dynamics Research (BDR) Kouai Kagaku 17 FOCUS Number Biolabo Three K Computer Mae Sta. Konan Comnet University Integrated Research Center of Kobe University JASPEC With animal, RI testing labs and CPC Monthly rent Monthly rent (without tax) Monthly rent Monthly rent (without tax) RIKEN Center for Nichii RIKEN Interdisciplinary Theoretical and Mathematical Sciences Program (IIB) (without tax) O L Office: ¥2,600 /m O (without tax) O S Lab: ¥3,100/m Computational Science (R-CCS) WAKITA Kobe Animal R-CCS Office: ¥2,800 /m Maintenance fee: ¥1,200 /m Lab: ¥3,000 – 4,200/m CPC: ¥4,000/m L M Kingdom Trans Genic Lab: ¥2,500/m YANAI Primmune Maintenance fee included Maintenance fee: KNC Laboratories Office maintenance fee: ¥1,100 /m ¥1,000 /m New Drug Lab maintenance fee: ¥930/m RI testing labs Universities Offices for rent Research Center Medical companies Research institutes Nippon CycloChem enable Technology Solution Advantech Other companies Hospitals MEDDEC and facilities Nisshin International Kobe Hybrid Computational Science Manufacturing Technology Association Pharmaceutical 3 Manufacturing Technology Association Kita Futo Building Industries To Kobe Airport of Biologics Development Facility Medical Plaza (IMP) Business Center Research Support Center of Biologics Development Facility ↓ 11 (PI first stage) 13 15 (KHBC) 17 (FOCUS) P O L M P R R Kobe Gakuin Naka Koen Sta. Monthly rent (without tax) Monthly rent Monthly rent (without tax) Monthly rent (without tax) University 14 Industrial facility site Manufacturing factory site Cultural / research facility site Kita Futo Sta. Office: ¥2,600 /m O (without tax) Shared use machines Lab: ¥4,400/m L Office: ¥180,000 – O Hyogo University of Research institute / Research institute or factories / Operation rooms Health Sciences 11 Main business Factory Maintenance fee: ¥740 /m ¥3,800 /m Maintenance fee included 240,000/ room Kobe Women’s University Head office / Service office universities with research institute Maintenance fee included Industrial area or semi-industrial Area of category Commercial area area (proper site for factories) Semi-industrial area Minatojima Sta. The Kobe Chamber of Building to land ratio 80% 60% 60% Commerce and Industry Port Island Building Shimin Byoin Mae Rental Offices & Labs 12 (PI first stage) 14 (PI first stage) 16 Building Floor area ratio 400% 200% 200% P R P Port Monthly rent (without tax) Monthly rent Monthly rent Check here S L Island Minimum area for sales / lease 1,000m 900m 2,000m Office: ¥3,100 /m O (without tax) O (without tax) O for details! Kobe Maintenance fee: ¥1,380 /m (with tax) Office: ¥2,400 /m Office/Lab: ¥3,000 /m Airport Kobe Airport Sta. Sale price per m ¥175,000 to 350,000 ¥128,400 to 214,000 ¥115,600 to 214,000 Maintenance fee: ¥970 /m Maintenance fee: ¥1,000 /m ● Maximum discount rates vary by the area. *The chart colors refer to the map. 7 Please contact us for more information. 8 三田西IC

大山崎JCT 京滋バイパス 吉川JCT 福知山線 新名神高速道路 久御山JCT 吉川IC Location 高槻JCT Living in Kobe 神戸三田IC 神戸JCT 大阪府 京阪本線 Kobe offers both the convenience of a city and the richness of nature. In this special city, Easy神戸北IC access to cities in Japan and to the world 東海道新幹線 茨木IC you can enjoy both work and your lifestyle to the fullest 三木JCT 80 minutes西宮北IC to Haneda Airport in Tokyo from KBIC, and only 12名神高速道路 minutes to Sannomiya, the center of Kobe. TASTE 中国池田IC 東海道本線 京奈和自動車道 TASTE Kobe City ▲ Mt. Rokko 第2京阪道路

Mt. Maya Hankyu Railway Shin-Osaka Shin-Kobe Sta. ▲ Amagasaki Sannomiya Shin-Kobe Hanshin Railway Umeda Shinkansen門真JCT Sta. 奈良奥山 Harbor highway JR About 12 ドライブウェイmin. LIVE WALK Osaka Kobe City Subway Sannomiya Hankyu Railway to Sannomiya Kyobashi 東大阪JCT 奈良 Hanshin Railway by Port Liner

Port Liner

under construction Osaka Bayshore route 天理IC Kobe Airport (Marine Air) Iryo Center Sta. About 35 min. SENSE MOVE to Osaka K Computer Mae Sta.法隆寺IC by local train 藤井寺IC About min. About 30 min. 香芝IC 5 from Kobe Airport KOBE Kobe Airport to Kobe Airport to Kansai Int’l Airport (KIX) by Port Liner by High speed boat Port Island 近鉄大阪線 C KOBE TOURISM BUREAU Shinkansen (bullet train) Results of Critical Care and 奈良県 Quality of Living Park Area per Citizen → Tokyo about 170min. City Ranking Emergency Medical Center (excluding green spaces) Shin- → Nagoya about 70min. Kobe City Medical Center General Hospital Hakata about 140min. 284 facilities among major cities Kansai Int’l Airport Kobe → nationwide Hiroshima about 70min. in in Ranked1st in Japan → 2nd Asia1st Japan Ranked1st for 5 consecutive years Mercer’s 2019 Quality of Living Survey Ministry of Health, Labour and 2017 edition (Quality of Living Survey) City rankings Welfare, Critical Care and Comparative Statistical Emergency Center Evaluation (FY 2018) Chronology of Major Cities Kobe Airport to 11 Cities Sophisticated Degree of Desirability Raising Children Number of → Haneda (Tokyo) about 70min. in Kobe Universities/ (*9 round和歌山県 trips per day) Designed City Ranking for Living is Enjoyable Jr. Colleges → New Chitose about 120min. among among Kobe Sendai about 90min. 1000 municipalities 1000 municipalities → Ranked Ranked Ranked nd Airport New Chitose Airport 1st nationwide 2nd nationwide. 2 → Naha about 135min. among major cities in Japan 和歌山ICNagasaki about 75min. Ministry of Education, Culture, 和歌山 → Brand Research Institute and Brand Research Institute and 93.2% Matsumoto about min. Regional Brand Survey 2018 Regional Brand Survey 2019 Sports, Science and Technology, → 60 2018 Kobe survey School Basic Survey for 2019 *As of March 2020 Aomori Airport

Sendai Airport PICK UP Moving Expenses Subsidy System Subsidies for moving expenses of employees who move from outside of Kobe to start working Ibaraki Airport in an industrial complex. (Up to ¥200,000) Izumo Airport Matsumoto Airport Haneda Airport Kobe City Official Immigration Portal Site Nagasaki Airport Kochi Airport Learn what Kobe can offer along with some useful information. This is a website for people who are thinking Kagoshima Airport about moving to Kobe. (Only available in Japanese) Naha Airport https://kobeaddress.city.kobe.lg.jp/

9 10 If you are interested in expanding to KBIC, please contact or check our website. Kobe City Biomedical Innovation and New Industry Headquarters, Kobe Biomedical Innovation Cluster Department, Corporate Development Division Kobe City Hall, 6-5-1, Kano-cho, Chuo-ku, Kobe 650-8570 JAPAN TEL:078-322-6341 MAIL:[email protected]

The latest information is now available on our website!

KBIC’s Scan here to subscribe to our official website E-newsletter (E-newsletter is only available in Japanese) It provides information about KBIC. https://www.fbri-kobe.org/kbic/english/ https://www.fbri-kobe.org/kbic/english/contact/magazine.php

Issued/March 2020 Registered as print publicity of Kobe No. 301 of 2014 (type A-1 printed publicity)