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ANNUAL REVIEW 1 October 2005–30 September
WELLCOME TRUST ANNUAL REVIEW 1 October 2005–30 September 2006 ANNUAL REVIEW 2006 The Wellcome Trust is the largest charity in the UK and the second largest medical research charity in the world. It funds innovative biomedical research, in the UK and internationally, spending around £500 million each year to support the brightest scientists with the best ideas. The Wellcome Trust supports public debate about biomedical research and its impact on health and wellbeing. www.wellcome.ac.uk THE WELLCOME TRUST The Wellcome Trust is the largest charity in the UK and the second largest medical research charity in the world. 123 CONTENTS BOARD OF GOVERNORS 2 Director’s statement William Castell 4 Advancing knowledge Chairman 16 Using knowledge Martin Bobrow Deputy Chairman 24 Engaging society Adrian Bird 30 Developing people Leszek Borysiewicz 36 Facilitating research Patricia Hodgson 40 Developing our organisation Richard Hynes 41 Wellcome Trust 2005/06 Ronald Plasterk 42 Financial summary 2005/06 Alastair Ross Goobey 44 Funding developments 2005/06 Peter Smith 46 Streams funding 2005/06 Jean Thomas 48 Technology Transfer Edward Walker-Arnott 49 Wellcome Trust Genome Campus As at January 2007 50 Public Engagement 51 Library and information resources 52 Advisory committees Images 1 Surface of the gut. 3 Zebrafish. 5 Cells in a developing This Annual Review covers the 2 Young children in 4 A scene from Y fruit fly. Wellcome Trust’s financial year, from Kenya. Touring’s Every Breath. 6 Data management at the Sanger Institute. 1 October 2005 to 30 September 2006. CONTENTS 1 45 6 EXECUTIVE BOARD MAKING A DIFFERENCE Developing people: To foster a Mark Walport The Wellcome Trust’s mission is research community and individual Director to foster and promote research with researchers who can contribute to the advancement and use of knowledge Ted Bianco the aim of improving human and Director of Technology Transfer animal health. -
Curriculum Vitae: Catherine Louise Johnson
Curriculum Vitae: Catherine Louise Johnson Address: Dept. Earth, Ocean and Atmospheric Sciences Email: [email protected] University of British Columbia Vancouver. Citizenship: USA Planetary Science Institute, Tucson, AZ Email: [email protected] Employment History 2010 – present: University of British Columbia, Vancouver. Professor of Geophysics 2010 – present: Planetary Science Institute, Tucson. Senior Scientist 2006 – 2010: University of British Columbia, Vancouver. Associate Professor of Geophysics 2003 – 2006: Scripps Institution of Oceanography. Associate Professor of Geophysics 2001 – 2003: Scripps Institution of Oceanography. Assistant Professor of Geophysics 1998 – 2001: Incorporated Research Institutions for Seismology (IRIS) Education & Outreach Program Manager 1995 – 1997: Carnegie Institution of Washington. Postdoctoral Researcher Education 1989 – 1994: Scripps Institution of Oceanography, UCSD. PhD in Geophysics 1985 – 1989: University of Edinburgh, Edinburgh, Scotland. B. Sc. Honors, Geophysics 1987 – 1988: University of Pennsylvania, Philadelphia. Junior year abroad Major Areas of Research Contributions: Comparative planetary geophysics: The magnetic fields of Mercury, Mars, Earth and the Moon; lithospheric structure on, and interior evolution of, Venus; lunar and martian seismicity and interior structure. Mission Experience 2012 – 2018: Co-I, InSight Discovery Mission. 2011 – 2018: Co-I, OSIRIS-REx Mission 2015 – 2018: OSIRIS-REx Laser Altimeter (OLA) Deputy Instrument Scientist. 2007 – 2016: Participating Scientist, MESSENGER Mission. Vice Chair, Geophysics Group, MESSENGER Science Steering committee (2013-2016). Honors 2014: Bullard Lecturer, Geomagnetism, Paleomagnetism and Electromagnetism Section, American Geophysical Union (AGU) Fall Meeting. 2013: Fellow, American Geophysical Union. 2009: 3-year Canadian NSERC Discovery Accelerator Grant for 2010-2013. 100 total are awarded each year across all NSERC Science and Engineering Disciplines. 2006 – 2007: Peter Wall Early Career Scholar, UBC. -
Functional Effects Detailed Research Plan
GeCIP Detailed Research Plan Form Background The Genomics England Clinical Interpretation Partnership (GeCIP) brings together researchers, clinicians and trainees from both academia and the NHS to analyse, refine and make new discoveries from the data from the 100,000 Genomes Project. The aims of the partnerships are: 1. To optimise: • clinical data and sample collection • clinical reporting • data validation and interpretation. 2. To improve understanding of the implications of genomic findings and improve the accuracy and reliability of information fed back to patients. To add to knowledge of the genetic basis of disease. 3. To provide a sustainable thriving training environment. The initial wave of GeCIP domains was announced in June 2015 following a first round of applications in January 2015. On the 18th June 2015 we invited the inaugurated GeCIP domains to develop more detailed research plans working closely with Genomics England. These will be used to ensure that the plans are complimentary and add real value across the GeCIP portfolio and address the aims and objectives of the 100,000 Genomes Project. They will be shared with the MRC, Wellcome Trust, NIHR and Cancer Research UK as existing members of the GeCIP Board to give advance warning and manage funding requests to maximise the funds available to each domain. However, formal applications will then be required to be submitted to individual funders. They will allow Genomics England to plan shared core analyses and the required research and computing infrastructure to support the proposed research. They will also form the basis of assessment by the Project’s Access Review Committee, to permit access to data. -
Features China Introduction
Features China Introduction Tom Blundell (President, the Biochemical Society) This issue of The Biochemist is focused on biochemistry in China. It is timely because it reflects the history of biochemical research collaboration between Chinese and UK scientists, not only by looking back over the last century, but also by reviewing some of the strengths of biochemical research in China in 2011. Downloaded from http://portlandpress.com/biochemist/article-pdf/33/5/4/3914/bio033050004.pdf by guest on 27 September 2021 It has been a busy year for the Biochemical Society, which both in the UK and China. But there were interactions is celebrating its first century. It will do so at the Centenary before Needham became involved. In this issue, Randy Celebration event at the Royal Society in London in Poon draws our attention to one of these, the first paper December, but it has already done so very impressively in from China published in a journal of the Biochemical Shanghai in May with a Joint Sino–UK Protein Symposium. Society. In 1926 Ernest Tso of the Peking Union Medical There we heard about truly momentous contributions College described vitamins in preserved duck eggs, arising from interactions of influential scientists from maintaining they are “as much used on the table as is both China and UK during the last century. Just before cheese in Western countries”. the Symposium, also in May 2011, the Biochemical Journal We should also celebrate Wang Ying-Lai, who did his opened its China office in Beijing with a mini-symposium. PhD in Cambridge between 1938 and 1941. -
Cambridge University Reporter Special Number 3
2 OFFICERS NUMBER–MICHAELMAS TERM 2000 SPECIAL NO.3 PA RT I Chancellor: H.R.H. The Prince PHILIP, Duke of Edinburgh, T Vice-Chancellor: Prof. Sir Alec BROERS, CHU Deputy Vice-Chancellors: for –,A.M.LONSDALE, NH,O.S.O’NEILL, N,Q.R.D.SKINNER, CHR, D. E. NEWLAND, SE, Prof. D. H. MELLOR, DAR Pro-Vice-Chancellors: ,A.M.LONSDALE, NH, June , D. H. MELLOR, DAR, Dec. High Steward: Vacant Deputy High Steward: , The Rt Hon. Lord RICHARDSON, CAI Commissary: , The Rt Hon. Lord OLIVER, TH Proctors for ‒: F. H. KING, M Deputy: C. A. T. MALONE, NH R. J. STIBBS, DOW Deputy: S. A. T. REDFERN, JE Orator: ,A.J.BOWEN, JE Registrary: ,T.J.MEAD, W Deputy Registrary: ,N.J.B.A.BRANSON, DAR Secretary General of the Faculties: ,D.A.LIVESEY, EM Deputy Secretary General of the Faculties: ,G.P.ALLEN, W Librarian: ,P.K.FOX, SE Deputy Librarians: ,D.J.HALL, W , A. MURRAY, W Treasurer: ,J.M.WOMACK, TH Director of the Fitzwilliam Museum and Marlay Curator: ,D.D.ROBINSON, CL Development Director: Vacant Esquire Bedells: ,J.P.EMMINES, PET ,J.H.WILLIAMS, HH University Advocate: ,N.M.PADFIELD, F, Deputy University Advocate: ,P.J.ROGERSON, CAI, OFFICERS IN INSTITUTIONS PLACED UNDER THE SUPERVISION OF THE GENERAL BOARD PROFESSORS Aeronautical Engineering, Francis Mond W. N. D AWES, CHU Aerothermal Technology Vacant African History J. I LIFFE, JN American History, Paul Mellon A. J. BADGER, SID American History and Institutions, Pitt Vacant Anatomy W.A. HARRIS, CL Anaesthesia D. K. MENON Ancient History M. -
Crystal Structures of Native and Inhibitedforms of Human Cathepsin
Proc. Natl. Acad. Sci. USA Vol. 90, pp. 6796-6800, July 1993 Biochemustry Crystal structures of native and inhibited forms of human cathepsin D: Implications for lysosomal targeting and drug design (aspartic protcase/N-linked oligosaccharide/pepstatin A) ERic T. BALDWIN*, T. NARAYANA BHAT*, SERGEI GULNIK*, MADHUSOODAN V. HOSUR*t, RAYMOND C. SOWDER Il, RAUL E. CACHAU*, JACK COLLINS*, ABELARDO M. SILVA*, AND JOHN W. ERICKSON*§ *Structural Biochemistry Program, Frederick Biomedical Supercomputing Center and tAIDS Vaccine Program, Program Resources Inc./DynCorp, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, MD 21702 Communicated by David R. Davies, March 24, 1993 (receivedfor review February 4, 1993) ABSTRACT Cathepsin D (EC 3.4.23.5) is a lysosomal duced in the vicinity of the growing tumor, may degrade the protease suspected to play important roles in protein catabo- extracellular matrix and thereby promote the escape of lism, antigen processing, degenerative diseases, and breast cancer cells to the lymphatic and circulatory systems and cancer progresson. Determination of the crystal structures of enhance the invasion of new tissues (17, 18). The design of cathepsin D and a complex with pepstatin at 2.5 A resolution potent and specific inhibitors of cathepsin D will aid the provides insights into inhibitor binding and lysosomal targeting further elucidation of the roles of this enzyme in human for this two-chain, N-glycosylated aspartic protease. Compar- disease. We previously described the purification and crys- ison with the structures of a complex of pepstatin bound to tallization ofhuman cathepsin D from liver (3); similar studies rhizopuspepsin and with a human renin-bihbitor complex have been reported recently for cathepsin D isolated from revealed differences in subsite structures and inhibitor-enzyme bovine liver (19) and human spleen (20). -
Part I Officers in Institutions Placed Under the Supervision of the General Board
2 OFFICERS NUMBER–MICHAELMAS TERM 2009 [SPECIAL NO.7 PART I Chancellor: H.R.H. The Prince PHILIP, Duke of Edinburgh, T Vice-Chancellor: 2003, Prof. ALISON FETTES RICHARD, N, 2010 Deputy Vice-Chancellors for 2009–2010: Dame SANDRA DAWSON, SID,ATHENE DONALD, R,GORDON JOHNSON, W,STUART LAING, CC,DAVID DUNCAN ROBINSON, M,JEREMY KEITH MORRIS SANDERS, SE, SARAH LAETITIA SQUIRE, HH, the Pro-Vice-Chancellors Pro-Vice-Chancellors: 2004, ANDREW DAVID CLIFF, CHR, 31 Dec. 2009 2004, IAN MALCOLM LESLIE, CHR, 31 Dec. 2009 2008, JOHN MARTIN RALLISON, T, 30 Sept. 2011 2004, KATHARINE BRIDGET PRETTY, HO, 31 Dec. 2009 2009, STEPHEN JOHN YOUNG, EM, 31 July 2012 High Steward: 2001, Dame BRIDGET OGILVIE, G Deputy High Steward: 2009, ANNE MARY LONSDALE, NH Commissary: 2002, The Rt Hon. Lord MACKAY OF CLASHFERN, T Proctors for 2009–2010: JEREMY LLOYD CADDICK, EM LINDSAY ANNE YATES, JN Deputy Proctors for MARGARET ANN GUITE, G 2009–2010: PAUL DUNCAN BEATTIE, CC Orator: 2008, RUPERT THOMPSON, SE Registrary: 2007, JONATHAN WILLIAM NICHOLLS, EM Librarian: 2009, ANNE JARVIS, W Acting Deputy Librarian: 2009, SUSANNE MEHRER Director of the Fitzwilliam Museum and Marlay Curator: 2008, TIMOTHY FAULKNER POTTS, CL Director of Development and Alumni Relations: 2002, PETER LAWSON AGAR, SE Esquire Bedells: 2003, NICOLA HARDY, JE 2009, ROGER DERRICK GREEVES, CL University Advocate: 2004, PHILIPPA JANE ROGERSON, CAI, 2010 Deputy University Advocates: 2007, ROSAMUND ELLEN THORNTON, EM, 2010 2006, CHRISTOPHER FORBES FORSYTH, R, 2010 OFFICERS IN INSTITUTIONS PLACED UNDER THE SUPERVISION OF THE GENERAL BOARD PROFESSORS Accounting 2003 GEOFFREY MEEKS, DAR Active Tectonics 2002 JAMES ANTHONY JACKSON, Q Aeronautical Engineering, Francis Mond 1996 WILLIAM NICHOLAS DAWES, CHU Aerothermal Technology 2000 HOWARD PETER HODSON, G Algebra 2003 JAN SAXL, CAI Algebraic Geometry (2000) 2000 NICHOLAS IAN SHEPHERD-BARRON, T Algebraic Geometry (2001) 2001 PELHAM MARK HEDLEY WILSON, T American History, Paul Mellon 1992 ANTHONY JOHN BADGER, CL American History and Institutions, Pitt 2009 NANCY A. -
IUPAB NEWS No
INTERNATIONAL UNION for PURE and APPLIED BIOPHYSICS IUPAB NEWS No. 59, December, 2012 Editor: Louise Matheson Email: [email protected] Activities of the INTERNATIONAL UNION for PURE and APPLIED BIOPHYSICS From the Secretary-General: Professor C.G. dos Remedios, Bosch Institute, Anderson Stuart Building F13, University of Sydney, NSW 2006, Australia. Courier address: Room W103 Anderson Stuart Building (F13), Fisher Road, The University of Sydney, 2006, Australia. Telephone: (+61) 2 9351 3209. Facsimile: (+61) 2 9351 6546 Email: [email protected] IUPAB is registered in France according Loi du 1er Juillet 1901-Art. 5, n° ordre 03/000309, n° dossier 00158190 CONTENTS Editor’s Note page 3 Report from the President, page 4 Professor Gordon C.K. Roberts Report from the Secretary-General, page 6 Professor Cris dos Remedios Biophysical Reviews – Report from page 9 Professor Jean Garnier, Editor-in-Chief EBSA joins IUPAB – Report from page 10 Professor Anthony Watts General News: BSC visits Brazil page 12 Progress of a recipient of an IUPAB Young page 13 Scientist Award Women in Science -- page 14 Professor Frances Separovic Obituaries – page 15 Dame Louise Napier Johnson and Professor Ivano Bertini 2 Editor’s Note The coming year will also see the continuation of serious prep- arations for the 2014 IBC to be held in Brisbane. This promises to be a stimulating and exciting Congress in a spectacular location. The photograph below was taken by the Treasurer, Professor Patrick Cozzone, at the planning meeting held at the Brisbane Convention Centre in September. It shows (L – R) Professors Brett Hambly, Convenor, Gordon Roberts, One of the changes in 2012 has IUPAB President, and Glenn King been the updating of the IUPAB who is Joint Program Chair with website. -
Iisc-Alumni Association- M.Vijayan Lecture. Cross Fertilisation: How
IISc-Alumni Association- M.Vijayan Lecture. Cross Fertilisation: How Crystallography has built on Mathematics. Eleanor Dodson 17th August 2017 Nostalgia time: I cannot resist revisiting old photographs! Oxford 1968? Wedding Day – July 1969 DCH building first insulin model Vijayan lost in shadows? Oxford lab - 1969 Britishx5, Indian, NZ, Aust. David Phillips, Dorothy, Tony North, Thomas, Vijaya, Tom Blundell, Ted Baker, EJD Bangalore – 1970? Bangalore 1970s Kalyani, Vijayan, Tom Blundell -1975? Bangalore – 1979-80. Vijanan Davi Kalyani Bangalore 2007: Guy's 70th Birthday Cake Workshop 2008 DCH & Siv Ramasechan – 1965 our Anomalous Dispersion Guru First anomalous data measurements done in Oxford ~ 1960 on B12 derivative by K. Venkatesan Validation: More Thought Experiments: G.N. Ramachandran Mathematics in the Service of Science? Michael Mosley -BBC 2010 “Knowledge leaps forward when brilliant experiments are analysed by independent minds.” He was referring to the discovery that Mars moves in an elliptical orbit around the sun – established by Johannes Kepler -1599 using the observations of Tycho Brahe. Mathematics in the Service of Crystallography? Structure Solution exploits: Fundamental Mathematical concepts (Some elegant, but restricted to 3D for structure, and 2D for diffraction) Technical Mathematics and Computation (messy and very easy to get wrong!) Statistics (Much needed but messy too) Why crystallography? Quote: DCH: I also first learnt at the same time about biochemistry which provided me with the molecules it seemed most desirable to 'see'. …[The] great advantage of X-ray analysis as a method of chemical structure analysis is its power to show some totally unexpected and surprising structure and to do so with absolute certainty…. -
CRYSTALLOGRAPHY NEWS British Crystallographic Association
ISSN 1467-2790 CRYSTALLOGRAPHY NEWS British Crystallographic Association No.78 September 2001 BCA Spring Meeting 2002 Dorothy Hodgkin - RSC Landmark Fibre Diffraction Crystallography and Antiquities 2001 Walter Hälg Prize Quarterly Book Reviews IInternational CCentre for DDiffraction DData 1941—Sixty Years—2001 Serving the Scientific Community Release 2001 of the Powder Diffraction File™ Featuring ❖ Over 87,500 experimental patterns ❖ 2,500 new experimental patterns added for Release 2001 ❖ Over 49,000 patterns calculated from the ICSD database ❖ 2,821 new calculated patterns added for Release 2001 ❖ Interplanar (d) spacings, relative intensities (Int), and Miller indices ❖ Chemical formula, compound name, mineral name, structural formula, crystal system, physical data, experimental parameters, and references when available ❖ Quality mark for each experimental pattern for estimate of reliability ❖ Entries indexed for subfile searches ❖ Dedication to detail and scientific purpose ❖ Four-tiered editorial process ❖ Highest standards for accuracy and quality Ask about our special Anniversary pricing Visit us at www.icdd.com Phone: 610.325.9814 ❖ Sales: 610.325.9810 ❖ Fax: 610.325.9823 ❖ [email protected] ICDD, the ICDD logo, and PDF are registered trademarks of the JCPDS—International Centre for Diffraction Data. Powder Diffraction File is a trademark of the JCPDS—International Centre for Diffraction Data. AA newnew creativecreative forceforce inin X-rayX-ray DiffractionDiffraction NEW Helijet – helium jet for cryocrystallography • Base temperature <15 K Our products include: Oxford Diffraction • 2 litres per hour helium is a new limited company owned Xcalibur™ automated 4-circle consumption at 15 K in joint venture by Oxford kappa X-ray diffractometer • Uniform temperature distribution Instruments and Kuma Diffraction. -
Louise Johnson (1940–2012) Biophysicist Who Helped to Establish the Field of Structural Biology
COMMENT OBITUARY Louise Johnson (1940–2012) Biophysicist who helped to establish the field of structural biology. ouise Johnson transformed our under- Laboratory of Molecular Biophysics at the Johnson’s many achievements included standing of how complex enzymes and University of Oxford. establishing the structure of a large and other proteins work. By combining her I first encountered Johnson about ten complex enzyme called glycogen phos- Lin-depth knowledge of X-ray crystallogra- years later. I was a first-year undergradu- phorylase. Present in muscle, this enzyme phy with a long-standing interest in bio- ate at Oxford studying biochemistry, and turns inert glycogen into the sugar needed chemistry, she helped to launch structural my tutor sent me to her to learn the basics to power physical activity. Johnson showed biology as a new discipline. how the addition or removal Johnson, who died on of phosphate groups from 25 September, was born the protein regulates its on 26 September 1940 activity. (Phosphorylation in Worcester, UK. She has since turned out to be a attended Wimbledon High key form of regulation in all School for Girls in Lon- sorts of cellular processes.) don and then completed a She subsequently carried degree in physics at Univer- out a set of groundbreak- IMAGES A.-K. PURKISS, WELLCOME sity College London. ing studies on proteins that In 1962, Johnson started have key roles in the regula- a PhD at London’s Royal tion of cell division. Institution — working In all this work, Johnson under David Phillips, a pio- demonstrated that X-ray neer of protein crystallogra- crystallography could reveal phy. -
Smutty Alchemy
University of Calgary PRISM: University of Calgary's Digital Repository Graduate Studies The Vault: Electronic Theses and Dissertations 2021-01-18 Smutty Alchemy Smith, Mallory E. Land Smith, M. E. L. (2021). Smutty Alchemy (Unpublished doctoral thesis). University of Calgary, Calgary, AB. http://hdl.handle.net/1880/113019 doctoral thesis University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. Downloaded from PRISM: https://prism.ucalgary.ca UNIVERSITY OF CALGARY Smutty Alchemy by Mallory E. Land Smith A THESIS SUBMITTED TO THE FACULTY OF GRADUATE STUDIES IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY GRADUATE PROGRAM IN ENGLISH CALGARY, ALBERTA JANUARY, 2021 © Mallory E. Land Smith 2021 MELS ii Abstract Sina Queyras, in the essay “Lyric Conceptualism: A Manifesto in Progress,” describes the Lyric Conceptualist as a poet capable of recognizing the effects of disparate movements and employing a variety of lyric, conceptual, and language poetry techniques to continue to innovate in poetry without dismissing the work of other schools of poetic thought. Queyras sees the lyric conceptualist as an artistic curator who collects, modifies, selects, synthesizes, and adapts, to create verse that is both conceptual and accessible, using relevant materials and techniques from the past and present. This dissertation responds to Queyras’s idea with a collection of original poems in the lyric conceptualist mode, supported by a critical exegesis of that work.