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Chemical Threat Agents Call Poison Control 24/7 for Treatment Information 1.800.222.1222 Blood Nerve Blister Pulmonary Metals Toxins
CHEMICAL THREAT AGENTS CALL POISON CONTROL 24/7 FOR TREATMENT INFORMATION 1.800.222.1222 BLOOD NERVE BLISTER PULMONARY METALS TOXINS SYMPTOMS SYMPTOMS SYMPTOMS SYMPTOMS SYMPTOMS SYMPTOMS • Vertigo • Diarrhea, diaphoresis • Itching • Upper respiratory tract • Cough • Shock • Tachycardia • Urination • Erythema irritation • Metallic taste • Organ failure • Tachypnea • Miosis • Yellowish blisters • Rhinitis • CNS effects • Cyanosis • Bradycardia, bronchospasm • Flu-like symptoms • Coughing • Shortness of breath • Flu-like symptoms • Emesis • Delayed eye irritation • Choking • Flu-like symptoms • Nonspecific neurological • Lacrimation • Delayed pulmonary edema • Visual disturbances symptoms • Salivation, sweating INDICATIVE LAB TESTS INDICATIVE LAB TESTS INDICATIVE LAB TEST INDICATIVE LAB TESTS INDICATIVE LAB TESTS INDICATIVE LAB TESTS • Increased anion gap • Decreased cholinesterase • Thiodiglycol present in urine • Decreased pO2 • Proteinuria None Available • Metabolic acidosis • Increased anion gap • Decreased pCO2 • Renal assessment • Narrow pO2 difference • Metabolic acidosis • Arterial blood gas between arterial and venous • Chest radiography samples DEFINITIVE TEST DEFINITIVE TEST DEFINITIVE TEST DEFINITIVE TESTS DEFINITIVE TESTS • Blood cyanide levels • Urine nerve agent • Urine blister agent No definitive tests available • Blood metals panel • Urine ricinine metabolites metabolites • Urine metals panel • Urine abrine POTENTIAL AGENTS POTENTIAL AGENTS POTENTIAL AGENTS POTENTIAL AGENTS POTENTIAL AGENTS POTENTIAL AGENTS • Hydrogen Cyanide -
Nerve Agent - Lntellipedia Page 1 Of9 Doc ID : 6637155 (U) Nerve Agent
This document is made available through the declassification efforts and research of John Greenewald, Jr., creator of: The Black Vault The Black Vault is the largest online Freedom of Information Act (FOIA) document clearinghouse in the world. The research efforts here are responsible for the declassification of MILLIONS of pages released by the U.S. Government & Military. Discover the Truth at: http://www.theblackvault.com Nerve Agent - lntellipedia Page 1 of9 Doc ID : 6637155 (U) Nerve Agent UNCLASSIFIED From lntellipedia Nerve Agents (also known as nerve gases, though these chemicals are liquid at room temperature) are a class of phosphorus-containing organic chemicals (organophosphates) that disrupt the mechanism by which nerves transfer messages to organs. The disruption is caused by blocking acetylcholinesterase, an enzyme that normally relaxes the activity of acetylcholine, a neurotransmitter. ...--------- --- -·---- - --- -·-- --- --- Contents • 1 Overview • 2 Biological Effects • 2.1 Mechanism of Action • 2.2 Antidotes • 3 Classes • 3.1 G-Series • 3.2 V-Series • 3.3 Novichok Agents • 3.4 Insecticides • 4 History • 4.1 The Discovery ofNerve Agents • 4.2 The Nazi Mass Production ofTabun • 4.3 Nerve Agents in Nazi Germany • 4.4 The Secret Gets Out • 4.5 Since World War II • 4.6 Ocean Disposal of Chemical Weapons • 5 Popular Culture • 6 References and External Links --------------- ----·-- - Overview As chemical weapons, they are classified as weapons of mass destruction by the United Nations according to UN Resolution 687, and their production and stockpiling was outlawed by the Chemical Weapons Convention of 1993; the Chemical Weapons Convention officially took effect on April 291997. Poisoning by a nerve agent leads to contraction of pupils, profuse salivation, convulsions, involuntary urination and defecation, and eventual death by asphyxiation as control is lost over respiratory muscles. -
Toxic Industrial Chemicals
J R Army Med Corps 2002; 148: 371-381 J R Army Med Corps: first published as 10.1136/jramc-148-04-06 on 1 December 2002. Downloaded from Toxic Industrial Chemicals Introduction location to another. Depending on the The first chemical warfare agent of the available routes of movement, and quantity modern era, chlorine, was released with of chemical to be moved, transport can occur devastating effect on 22 April 1915 at Ypres, by truck or rail tank cars, over water by barge Belgium. Along a 4 mile front, German or boat, over land through above- or below- soldiers opened the valves of 1,600 large and ground pipelines and by air. 4,130 small cylinders containing 168 tons of Toxic chemicals may be produced by the chlorine.The gas formed a thick white cloud burning of materials (e.g., the burning of that crossed the first allied trenches in less Teflon produces perfluoroisobutylene) or by than a minute.The allied line broke, allowing their reaction if spilled into water (e.g. silanes the Germans to advance deep into allied produce hydrogen chloride and cyanides, territory. If the Germans had been fully hydrogen cyanide). prepared to exploit this breakthrough, the course and possibly the outcome of WWI Toxic Industrial Chemicals may have been very different. (TICs) Chlorine is a commodity industrial A Toxic Industrial Chemical (TIC) is defined chemical with hundreds of legitimate uses; it as: is not a "purpose designed" chemical warfare an industrial chemical which has a LCt50 agent. Phosgene, another commodity value of less than 100,000 mg.min/m3 in industrial chemical, accounted for 80% of any mammalian species and is produced in the chemical fatalities during WWI. -
Piratox Sheet N5 Suffocating Agents and Phosphine
Edition of October 2011 Piratox sheet #5: "Suffocating agents and phosphine Indicative list of concerned agents: Toxic compounds with suffocating action - Phosgene (CAS number: 75-44-5) - Chlorine (CAS number: 7782-50-5) - Methyl isocyanate (CAS number: 624-83-9) - But also: o Ammonia (CAS number: 7664-41-7) o Diphosgene or surpalite (CAS number: 503-38-8) o Chloropicrin (CAS number: 76-06-2) o Fluorine (CAS number: 7782-41-4) o Perfluoroisobutylene (CAS number: 382-21-8) o Fumigants o Marketed industrial and domestic products - Phosphine or PH3 or Hydrogen Phosphide (CAS number: 7803-51-2). ! Key points not to forget The 1st emergency step is the extraction of victims from the hazard area: rescuers must possess suitable breathing and eye protection. At ambient temperature (20°C) most suffocating agents are gases that penetrate the body via the respiratory route. They are thus poorly or non-persistent, frequently limiting victim decontamination needs to simple undressing. Most suffocating agents are heavier than air. They affect the respiratory system: glottis, bronchi, alveoli and cause eye damage. In pre-hospital settings, avoid any physical exertion that could promote the onset of pulmonary oedema. In general, the shorter the symptom onset time, the more serious the intoxication and the more severe the symptoms. Treatment is symptomatic only. All symptomatic choking gas victims must encouraged to rest, in a sitting position, under oxygen. The duration of surveillance for symptomatic subjects is of at least 12 to 24 hours. For Phosphine (PH3): o victims must be undressed and showered; o toxicity is respiratory, cardiac, renal and neurological; o subjects having inhaled PH3 and presenting with significant initial manifestations shall be monitored in the hospital for 48 to 72 hours, due to the risk of delayed acute pulmonary oedema. -
Combustion and Pyrolysis Kinetics of Chloropicrin J.-C
Combustion and Pyrolysis Kinetics of Chloropicrin J.-C. Lizardo-Huerta, B. Sirjean, L. Verdier, R. Fournet, Pierre-Alexandre Glaude To cite this version: J.-C. Lizardo-Huerta, B. Sirjean, L. Verdier, R. Fournet, Pierre-Alexandre Glaude. Combustion and Pyrolysis Kinetics of Chloropicrin. Journal of Physical Chemistry A, American Chemical Society, 2018, 122 (26), pp.5735 - 5741. 10.1021/acs.jpca.8b04007. hal-01921757 HAL Id: hal-01921757 https://hal.univ-lorraine.fr/hal-01921757 Submitted on 14 Nov 2018 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Combustion and Pyrolysis Kinetics of Chloropicrin J.-C. Lizardo-Huerta1, B. Sirjean1, L. Verdier2, R. Fournet1, P.-A. Glaude1* 1 Laboratoire Réactions et Génie des Procédés, CNRS, Université de Lorraine 1 rue Grandville BP 20451 54001 Nancy Cedex, France 2 DGA Maîtrise NRBC, Site du Bouchet, 5 rue Lavoisier, BP n°3, 91710 Vert le Petit, France Corresponding author : Pierre-Alexandre Glaude Laboratoire Réactions et Génie des Procédés 1 rue Grandville BP 20451 54001 Nancy Cedex, France Email:[email protected] 1 Abstract Chloropicrin (CCl3NO2) is widely used in agriculture as a pesticide, weed-killer, fungicide or nematicide. -
Process for the Synthesis of N-Methyl-N-Phenylaminoacrolein
Europäisches Patentamt *EP001477474A1* (19) European Patent Office Office européen des brevets (11) EP 1 477 474 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.7: C07C 221/00, C07C 223/02 17.11.2004 Bulletin 2004/47 (21) Application number: 03425306.2 (22) Date of filing: 13.05.2003 (84) Designated Contracting States: (72) Inventors: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR • Banfi, Aldo HU IE IT LI LU MC NL PT RO SE SI SK TR 20131 Milano (IT) Designated Extension States: • Mancini, Alfredo AL LT LV MK 26020 Spinadesco (Cremona) (IT) (71) Applicant: Clariant Life Science Molecules (Italia) (74) Representative: Pistolesi, Roberto et al SpA Dragotti & Associati SRL 21040 Origgio (Varese) (IT) Galleria San Babila 4/c 20122 Milano (IT) (54) Process for the synthesis of N-methyl-N-phenylaminoacrolein (57) A process is disclosed for manufacturing N-me- thyl-N-phenylaminoacrolein of formula (I) wherein R is a C3-C4 alkyl, said process being charac- terized in that the reaction between N-methylformanilide and said alkyl vinyl ether of formula (III) is carried out in the presence of phosgene, diphosgene or triphosgene which comprises reacting N-methylformanilide and an in a solvent selected from dioxane, acetonitrile and/or alkyl vinyl ether of formula (III) chlorobenzene. EP 1 477 474 A1 Printed by Jouve, 75001 PARIS (FR) 1 EP 1 477 474 A1 2 Description [0003] More in details, compound (I) can be converted into Fenal, by reaction with compound (IV) [0001] This invention relates to the synthesis of N-me- thyl-N-phenylaminoacrolein of formula (I) 5 10 15 and its use for the preparation of 3-[3-(4-Fluorophenyl)- 1-(1-Methylethyl)-1H-Indol-2-yl]-2-Propenal (II), herein- after referred to as "Fenal", 20 in acetonitrile in the presence of POCl3, as disclosed in WO 84/82131 and US-4739073. -
Goods-PDF-Brochures-Reducingagents.Pdf
ᮣᮣᮣᮣ Gelest, Inc. Gelest Gelest, Inc. Telephone: General 215-547-1015 Order Entry 888-734-8344 FAX: 215-547-2484 Internet: www.gelest.com Correspondence: 11 East Steel Road Morrisville, PA 19067, USA In Europe: ABCR GmbH & Co. KG Im Schlehert D-76187 Karlsruhe Germany Tel: +49 - 721 - 950610 Fax: +49 - 721 - 9506180 e-mail: [email protected] on-line catalog: www.abcr.de In Japan: AZmax Co. Ltd. 1-6-13 Tamasaki Nishi Ichihara City Chiba, 290-0044 Japan Tel: 81-436-20-2660 Fax: 81-436-20-2665 email: [email protected] on-line catalog: www.azmax.co.jp For further information consult our web site at: www.gelest.com For technical advice contact: Gerald L. Larson, Ph.D. Vice-President, Research Products e-mail [email protected] ©2004 Gelest, Inc. Gelest, Inc. Silicon-Based Reducing Agents Edited by Gerald L. Larson, Ph.D. Vice President, Research Products Materials for the reduction of: Aldehydes Ketones Acetals Ketals Esters Lactones Thioesters Enamines Imines Acids Amides Halides Olefins Metal Halides Supplement to the Gelest Catalog, “Silicon, Germanium & Tin Compounds, Metal Alkoxides and Metal Diketonates” which is available on request. (215) 547-1015 FAX: (215) 547-2484 www.gelest.com 1 Gelest, Inc. SILICON-BASED REDUCING AGENTS Introduction The widely-used organometallic-based reducing agents can be broadly classified as either ionic, such as lithium aluminum hydride and sodium borohydride, or free-radical such as tri-n-butyltin hydride. The mechanistic differences between these two classes of reducing agents very often complement one another in their ability to reduce organic substrates. -
Applications of Boronic Acids in Organic Synthesis
Applications of Boronic Acids in Organic Synthesis A dissertation presented by Pavel Starkov in partial fulfilment of the requirements for the award of the degree of DOCTOR OF PHILOSOPHY at UNIVERSITY COLLEGE LONDON Department of Chemistry Christopher Ingold Laboratories University College London 20 Gordon Street WC1H 0AJ London Declaration This dissertation is the result of my own work. Where information has been derived from other sources it has been clearly indicated so and acknowledged accordingly. /Pavel Starkov/ ii Abstract This thesis describes progress on the application of boronic acids and borate esters as catalysts and reagents in synthetic organic synthesis, focusing on two areas: one-pot enolate formation/aldol reactions and amide bond formation. Chapter 1 introduces the reader to boronic acids and derivatives thereof, their methods of preparation and their use in synthetic organic chemistry as reactants, reagents and catalysts. Chapter 2 covers current chemical methods and cellular alternatives for amide bond formation. Here, we also discuss our use of boron reagents for the activation of carboxylic acids as well as amides. Chapter 3 introduces a new concept in catalytic aldol reactions, i.e. an alternative strategy to access boron enolates in situ. The work covers successful demonstration of the feasibility of such an approach on an intramolecular system. A novel variation of aerobic Chan–Evans– Lam coupling, an intramolecular coupling of an aliphatic alcohol with a boronic acid using catalytic copper, is also introduced Chapter 4 builds on our observations on gold catalysis and especially that in relation to electrophilic halogenations. Chapter 5 contains full details of the experimental procedures. -
Toxic Exposures Kathy L
8 MODULE 8 Toxic Exposures Kathy L. Leham-Huskamp / William J. Keenan / Anthony J. Scalzo / Shan Yin 8 Toxic Exposures Kathy L. Lehman-Huskamp, MD William J. Keenan, MD Anthony J. Scalzo, MD Shan Yin, MD InTrODUcTIOn The first large-scale production of chemical and biological weapons occurred during the 20th century. World War I introduced the use of toxic gases such as chlorine, cyanide, an arsine as a means of chemical warfare. With recent events, such as the airplane attacks on the World Trade Center in New York City, people have become increasingly fearful of potential large-scale terrorist attacks. Consequently, there has been a heightened interest in disaster preparedness especially involving chemical and biological agents. The U.S. Federal Emergency Management Agency (FEMA) recommends an "all-hazards" approach to emergency planning. This means creating a simultaneous plan for intentional terrorist events as well as for the more likely unintentional public health emergencies, such as earthquakes, floods, hazardous chemical spills, and infectious outbreaks. Most large-scale hazardous exposures are determined by the type of major industries that exist and/or the susceptibility to different types of natural disasters in a given area. For example, in 1984 one of the greatest man-made disasters of all times occurred in Bhopal, India, when a Union Carbide pesticide plant released tons of methylisocyanate gas over a populated area, killing scores of thousands and injuring well over 250,000 individuals. The 2011 earthquake and tsunami in Japan demonstrated the vulnerability of nuclear power stations to natural disasters and the need to prepare for possible widespread nuclear contamination and radiation exposure. -
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Intermolecular Reductive C–N Cross Coupling of Nitroarenes and Boronic Acids by P[Superscript III]/P[Superscript V]#O Catalysis
Intermolecular Reductive C–N Cross Coupling of Nitroarenes and Boronic Acids by P[superscript III]/P[superscript V]#O Catalysis The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Citation Nykaza, Trevor V. et al. "Intermolecular Reductive C–N Cross Coupling of Nitroarenes and Boronic Acids by P[superscript III]/ P[superscript V]#O Catalysis." Journal of the American Chemical Society 140, 45 (2018): 15200-15205 © 2018 American Chemical Society As Published http://dx.doi.org/10.1021/jacs.8b10769 Publisher American Chemical Society (ACS) Version Author's final manuscript Citable link https://hdl.handle.net/1721.1/123674 Terms of Use Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. HHS Public Access Author manuscript Author ManuscriptAuthor Manuscript Author J Am Chem Manuscript Author Soc. Author Manuscript Author manuscript; available in PMC 2019 November 14. Published in final edited form as: J Am Chem Soc. 2018 November 14; 140(45): 15200–15205. doi:10.1021/jacs.8b10769. Intermolecular Reductive C–N Cross Coupling of Nitroarenes and Boronic Acids by PIII/Pv=O Catalysis Trevor V. Nykaza#†, Julian C. Cooper#†, Gen Li†, Nolwenn Mahieu†, Antonio Ramirez‡, Michael R. Luzung‡,∥,*, and Alexander T. Radosevich†,* †Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States. ‡Chemical and Synthetic Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, New Jersey 08903, United States. # These authors contributed equally to this work. -
Synthesis, Characterization and Biological Activity of Some New 1,3,4-Oxadiazole and Β-Lactams from Poly Acryloyl Chloride
Sura S. Raoof /J. Pharm. Sci. & Res. Vol. 11(7), 2019, 2764-2769 Synthesis, Characterization and Biological Activity of Some new 1,3,4-Oxadiazole and β-Lactams from poly Acryloyl chloride Sura S. Raoof Department of Pharmaceutical Chemistry,College of pharmacy,AL-Mustansiriyah University Abstract: In this work the new poly acryloyl chloride derivatives by reaction with hydrazine hydrate in presence of triethyl amine (Et3N) and DMSO as a solvent to prepare polymer (1). These derivatives polymers were synthesized by two parts. The first part(I) was included to formation of Schiff base polymers (2-5) by treatment polymer (1) with various aldehydes and ketones in presence DMSO as a solvent and glacial acetic acid. Then treatment the prepared polymers (2-5) with chloroacetyl chloride, triethyl amine and 1,4-dioxane as a solvent to product β- Lactam polymers (6-9). The second part (II) was reaction of polymer (1) with different aromatic carboxylic acid in presence POCl3, triethyl amine and DMSO as a solvent to prepared 1,3,4-oxadiazole polymers (10-12). All the newly prepared polymers were identified by physical properties, FT-IR , softening point, screened antibacterial studies and some of them 1H-NMR. Key word: poly acryloyl chloride , Schiff base , β-Lactam and 1,3,4-oxadiazole . INTRODUCTION : EXPERIMENTAL Poly acryloyl chloride can be prepared be reaction poly A) Supplied chemicals: acrylic acid with thionyl chloride [1]. Also, can be The chemicals such as Poly acryloyl chloride , DMSO, prepared Poly acryloyl chloride by exposure Acryloyl Phosphoryl chloride , Different aldehydes and ketones , chloride by UV light in quartz tubes to formation linear hydrazine etc. -
Draft Chemicals (Management and Safety) Rules, 20Xx
Draft Chemicals (Management and Safety) Rules, 20xx In exercise of the powers conferred by Sections 3, 6 and 25 of the Environment (Protection) Act, 1986 (29 of 1986), and in supersession of the Manufacture, Storage and Import of Hazardous Chemical Rules, 1989 and the Chemical Accidents (Emergency Planning, Preparedness and Response) Rules, 1996, except things done or omitted to be done before such supersession, the Central Government hereby makes the following Rules relating to the management and safety of chemicals, namely: 1. Short Title and Commencement (1) These Rules may be called the Chemicals (Management and Safety) Rules, 20xx. (2) These Rules shall come into force on the date of their publication in the Official Gazette. Chapter I Definitions, Objectives and Scope 2. Definitions (1) In these Rules, unless the context otherwise requires (a) “Act” means the Environment (Protection) Act, 1986 (29 of 1986) as amended from time to time; (b) “Article” means any object whose function is determined by its shape, surface or design to a greater degree than its chemical composition; (c) “Authorised Representative” means a natural or juristic person in India who is authorised by a foreign Manufacturer under Rule 6(2); (d) “Chemical Accident” means an accident involving a sudden or unintended occurrence while handling any Hazardous Chemical, resulting in exposure (continuous, intermittent or repeated) to the Hazardous Chemical causing death or injury to any person or damage to any property, but does not include an accident by reason only