DOCSLIB.ORG

Association of HLA-DRB3* 0202 and Serum Igg Antibodies to Chlamydia

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Association of HLA-DRB3* 0202 and Serum Igg Antibodies to Chlamydia Journal of Human Hypertension (2005) 19, 615–622 & 2005 Nature Publishing Group All rights reserved 0950-9240/05 $30.00 www.nature.com/jhh ORIGINAL ARTICLE Association of HLA-DRB3*0202 and serum IgG antibodies to Chlamydia pneumoniae with essential hypertension in a highly homogeneous population from Majorca (Balearic Islands, Spain) JM Zabay1, J Marco2, J Soler3, L Contu4, L Cappai4, C Carcassi4,GGo´mez2, JM Mulet3, MA Munar2 and C Viader1 1Fundacio´n Balear Transplant, Palma de Mallorca, Spain; 2Servicio de Nefrologı´a, Hospital Universitario Son Dureta, Palma de Mallorca, Spain; 3Laboratorio Inmunogen SL, Palma de Mallorca, Spain; 4Cattedra di Genetica Medica, Universita di Cagliari, Cagliari, Italy Separate studies investigating the relationship of ml in the group of individuals with sIgGa-Cp430 BU/ml essential hypertension (EH) with the HLA system and (OR (95% CI) adjusted for obesity, familial history of with Chlamydia pneumoniae (C. pneumoniae) infection EH and diabetes ¼ 2.06 (1.07–3.97), P ¼ 0.03, and ¼ 4.60 have given conflicting results. Our aim was to clarify (1.06–19.90), P ¼ 0.04, respectively). The association these relationships and determine whether the HLA between EH and sIgGa-Cp was observed in the system and C. pneumoniae infection interact with DRB3*0202( þ ) individuals, but not in the DRB3*0202(À) respect to the risk for EH. An association study (110 subgroup (OR (95% CI) ¼ 11.14 (1.92–64.54), P ¼ 0.004, essential hypertensives and 107 controls) was con- and ¼ 0.98 (0.22–4.43), P ¼ 0.64, respectively (P of the ducted in a highly homogeneous population in the Mantel–Haenszel test for homogeneity of OR ¼ 0.06)). In Balearic Island of Majorca (Spain). Molecular typing of our population, EH was positively associated with HLA- HLA-B and HLA-DRB and quantification of serum levels DRB3*0202 and with high levels of sIgGa-Cp. Moreover, of IgG antibodies to C. pneumoniae (sIgGa-Cp) were a significant interaction of DRB3*0202 on the effect determined. Student’s t-test, v2-statistics, logistic re- of sIgGa-Cp was observed, as the association of EH gression analysis, and general linear model ANOVA with these antibodies depended on the presence of were used for statistical analysis. The results showed DRB3*0202. that EH was related with HLA-DRB3*0202 in the whole Journal of Human Hypertension (2005) 19, 615–622. study population, and with levels of sIgGa-Cp463.5 BU/ doi:10.1038/sj.jhh.1001872; published online 12 May 2005 Keywords: MHC class II; Chlamydia pneumoniae; essential hypertension; genetics; infection; Majorca (Balearic Islands) Introduction been documented in linkage studies.2,3 However, studies to analyse the possible association between Essential hypertension (EH) is a complex genetic 1 EH and antigens or alleles of the HLA system, trait as blood pressure (BP) in each individual is mainly HLA-B and HLA-DR,3–8 have failed to yield due to the combined effects of variation at an consistent results. indeterminate number of BP-determining genetic Although not confirmed by other authors,9 a loci and environmental factors. One of the genetic positive association between Chlamydia pneumo- systems for which a possible relationship with EH niae (C. pneumoniae) infection and EH has recently has been considered is the HLA system and this has been reported.10–12 This observation expands the spectrum of cardiovascular diseases in which C. pneumoniae infection, through immune and Correspondence: Dr C Viader, Fundacio´n Balear Transplant, Avda inflammatory mechanisms, might play a role.13,14 Joan Miro´, 168. 07015 Palma de Mallorca, Spain. E-mail: [email protected] Based on these observations and given the para- Received 13 October 2004; revised 26 January 2005; accepted 3 mount importance of the HLA system in the March 2005; published online 12 May 2005 immune response, it is of great interest to clarify HLA class II, C. pneumoniae and essential hypertension JM Zabay et al 616 the possible relationship of EH with HLA alleles and known or suspected immunodeficiency, hyper- C. pneumoniae infection, as well as to investigate gammaglobulinaemia and connective or autoim- possible interactions between HLA alleles and mune disease. Since neither hypertensive patients C. pneumoniae infection with respect to the EH nor controls were acutely ill when their blood risk. We carried out a case–control study in which samples were collected, we did not expect to include we typed HLA-B, -DRB1, -DRB3, -DRB4 and -DRB5 a significant number of cases with acute C. pneumo- alleles and determined the serum levels of IgG niae infection. As a minimum, both parents and all antibodies to C. pneumoniae (sIgGa-Cp) in a highly four grandparents of patients and controls were homogeneous population in the Balearic Island required to have been born in Majorca. Furthermore, of Majorca (Spain). Our results showed a positive for each participant, both family names (people born association of EH with the allele HLA-DRB3*0202 in Spain officially have two family names, that of and with high levels of sIgGa-Cp, but no association their father, followed by that of their mother, and between sIgGa-Cp and EH was observed unless this women maintain these family names when they are allele was present. married) had to be characteristic of Majorca, and an effort was made to ensure that the patients and controls selected from each village had at least one of Materials and methods the most typical family names from that village. Study subjects Similar numbers of cases and controls were selected from each outpatient clinic. Cases and controls were The research protocol of this case–control study was age- and sex-matched as far as possible. approved by the Institutional Review Committees of the ‘Hospital Universitario Son Dureta’ and the ‘Gerencia Atencio´n Primaria de Mallorca (IBSA- Genetic analysis LUT)’. All participants (110 cases and 107 controls) gave their written, informed consent. Generic typing of HLA-DRB1, -DRB3, -DRB4, -DRB5 Participants were identified from medical records and -B loci, and high-resolution subtyping of HLA- at seven public outpatient clinics in villages located DRB1, -DRB3, -DRB4 and -DRB5 loci were per- formed by molecular techniques, as previously throughout Majorca, where over 75% of the at- 16 tended population were born on the island. The described. preselected individuals were asked to attend a specific appointment during which a questionnaire containing demographic, lifestyle and health-related Serological analysis issues was filled in, a medical examination includ- sIgGa-Cp levels were determined by a commercial ing anthropometry and BP measurement was per- quantitative ELISA kit (SeroCP Quant IgG, Savyon formed, and blood samples for genetic and Diagnostics Ltd., Israel) that uses as antigen purified serological analysis were collected from subjects elementary bodies from C. pneumoniae (TWAR-183) who were definitively enrolled. Laboratory data and gives the results as binding units (BU)/ml. The were gathered from medical records. The BP was assays were performed according to the manufac- measured manually with a calibrated sphygmoman- turer’s instructions. ometer by a skilled health professional; the mean of From the equivalences with a microimmunofluor- two BP measurements, separated by more than escence (MIF) method, these instructions establish 1 min, was taken as the BP for that day. that sera with o10 BU/ml are negative. Only hypertensive individuals without evidence of secondary forms of hypertension were eligible. From among these, those patients with severe Statistical analysis EH (systolic blood pressure (SBP) repeatedly X160 mmHg, or diastolic blood pressure (DBP) The between-groups comparison of quantitative and repeatedly X100 mmHg, or those receiving at least categorical variables was carried out by the unpaired two antihypertensive agents) were selected. We Student’s t-test and by the w2-statistics, respectively. chose individuals with severe EH as several pre- Allele families and alleles of the HLA system, as vious studies had shown that the relationship dichotomous variables, and the level of sIgGa-Cp,as between some genetic markers and EH is enhanced a continuous variable, were tested for association in this group of patients,15 and at least one study with EH by univariate and multivariate logistic reporting a positive association between C. pneu- regression analyses. Crude and adjusted odds ratio moniae infection and EH was also performed with (OR) and 95% confidence interval (CI) were calcu- severe essential hypertensives.10 Normotensive sub- lated from the univariate and multivariate logistic jects (SBP repeatedly o140 mmHg and DBP repeat- regression parameter estimates, respectively. The edly o90 mmHg) were selected as controls from P-values of the univariate analyses with the HLA among patients who had noncardiovascular symp- system were not corrected by the Bonferroni method toms or from individuals who participated in for multiple comparisons,17 mainly because the vaccination programmes. Exclusion criteria were existence of HLA haplotypes introduced considerable Journal of Human Hypertension HLA class II, C. pneumoniae and essential hypertension JM Zabay et al 617 uncertainty about the number of independent tests (BMI430 kg/m2) and frequency of family history of performed or implied. hypertension than controls. Diabetes was also more The effects of the explanatory variables on BP frequent in the group of patients than in the control level were investigated with the general linear group, but the difference did not reach statistical model ANOVA with adjustment for treatment, significance. BMI, age and sex. The association between EH and sIgGa-Cp was also tested by 2 Â 2 tables using Fisher’s exact test, Genetic data after transforming the level of antibodies in a Allele families or alleles that were identified in X20 dichotomous variable. The homogeneity of OR study participants were evaluated for their statisti- obtained from these tables was analysed by the cal association with EH.
Load more

Recommended publications
  • Memorial Day Sale Exclusive Rates· Book a Balcony Or Above and Receive up to $300 Onboard Credit ^ Plus 50% Reduced Deposit'
    Memorial Day Sale Exclusive Rates· Book a Balcony or above and receive Up to $300 Onboard Credit ^ plus 50% Reduced Deposit' Voyage No. Sail Date Itinerary Voyage Description Nights Japan and Alaska Tokyo (tours from Yokohama), Hakodate, Sakaiminato, Busan, Sasebo, Kagoshima, Tokyo (tours from Yokohama), Hakodate, Aomori, Otaru, Cross Q216B 5/8/2022 International DateLine(Cruise-by), Anchorage(Seward), Hubbard Glacier (Cruise-by), Juneau, Glacier Bay National Park (Cruise-by), Ketchikan, Japan and Alaska 38 Victoria, Vancouver, Glacier Bay National Park (Cruise-by), Haines, Hubbard Glacier (Cruise-by), Juneau, Sitka, Ketchikan, Victoria, Vancouver Tokyo (tours from Yokohama), Hakodate, Aomori, Otaru, Cross International Date Line (Cruise-by), Anchorage (Seward), Hubbard Glacier (Cruise- Q217B 5/17/2022 by), Juneau, Glacier Bay National Park (Cruise-by), Ketchikan, Victoria, Vancouver, Glacier Bay National Park (Cruise-by), Haines, Hubbard Glacier Japan and Alaska 29 (Cruise-by), Juneau, Sitka, Ketchikan, Victoria, Vancouver Tokyo (tours from Yokohama), Hakodate, Aomori, Otaru, Cross International Date Line (Cruise-by), Anchorage (Seward), Hubbard Glacier (Cruise- Q217N 5/17/2022 Japan and Alaska 19 by), Juneau, Glacier Bay National Park (Cruise-by), Ketchikan, Victoria, Vancouver Alaska Q218N 6/4/2022 Vancouver, Glacier Bay National Park (Cruise-by), Haines, Hubbard Glacier (Cruise-by), Juneau, Sitka, Ketchikan, Victoria, Vancouver Alaska 10 Q219 6/14/2022 Vancouver, Juneau, Hubbard Glacier (Cruise-by), Skagway, Glacier Bay National Park
    [Show full text]
  • The Holy See
    The Holy See PASTORAL VISIT TO CAGLIARI MEETING WITH WORKERS ADDRESS OF HOLY FATHER FRANCIS Largo Carlo Felice, Cagliari Sunday, 22 September 2013 Dear Brothers and Sisters, Good morning! I greet you all cordially: workers, business people, authorities, the families present and, in particular, Archbishop Arrigo Miglio, and the three of you who have told us about your problems, about your expectations and also about your inspirations. With this visit — as I said — I am starting with you, who make up the world of work. With this meeting I want above all to express my closeness to you, especially to the situations of suffering: to the many young people out of work, to people on unemployment benefits, or on a temporary basis, to business and tradespeople who find it hard to keep going. I am very familiar with this situation because of my experience in Argentina. I myself was spared it but my family wasn’t. My father went to Argentina as a young man full of illusions “of making it in America”. And he suffered in the dreadful recession of the 1930s. They lost everything! There was no work! And in my childhood I heard talk of this period at home.... I never saw it, I had not yet been born, but I heard about this suffering at home, I heard talk of it. I know it well! However, I must say to you: “Courage!”. Nevertheless I am also aware that for own my part I must do everything to ensure that this term “courage” is not a beautiful word spoken in passing! May it not be merely the smile of a courteous employee, a Church employee who comes and says “be brave!” No! I don’t want this! I want courage to come from within me and to impel me to do everything as a pastor, as a man.
    [Show full text]
  • Cagliari International Container Terminal
    CAGLIARI INTERNATIONAL CONTAINER TERMINAL THE CENTER AT YOUR SERVICE 1 Copyright Contship Italia Group 2019 CAGLIARI INTERNATIONAL CONTAINER TERMINAL MINIMAL DEVIATION FROM SUEZ–GIBRALTAR MAIN ROUTE Optimal weather conditions 365 d/y Zero delays on vessel maneuvring in-out EXTENDED HOME PORT FOR NORTH AFRICAN ECONOMIES 2 Copyright Contship Italia Group 2019 TOTAL RELIABILITY UPDATED 2019 WAIT AT ANCHOR VESSEL ON BERTH START OPERATIONS UNBERTHING AFTER (PILOT STATION) END OF OPERATIONS 1.5 Hours 20 Minutes 1.2 Hours AVERAGE DATA CALCULATED ON 192 OCEAN VESSELS AND 72 FEEDER VESSEL CALLS DURING 2018 3 Copyright Contship Italia Group 2019 CICT AT A GLANCE Handling Capacity Length of Quay Terminal Area 1.3 million TEUs 1,520 m 400,000 m2 3.6 million TEUs* 1,900 m* 900,000 m2* Water Depth Quay Cranes Yard Equipment Reefer Plugs 17 RTG 7 Gantry Crane 5 Reach Stacker 16 m (up to 18 rows) 10 Front Loader 1,000 1 Mobile Crane 31 Trucks *Future development *Future 32 Trailers UPDATED 2019 4 Copyright Contship Italia Group 2019 OPERATIONAL FLEXIBILITY AND RELIABILITY MAXIMUM RELIABILITY FOR MOTHER-MOTHER AND MOTHER-FEEDER DIRECT CONNECTIONS FLEXIBLE COMMENCEMENT OF ANY VESSEL OPERATION 5 Copyright Contship Italia Group 2019 VOLUMES (TEUs and Vessel Calls) 8.4 MILLION TEUS HANDLED 303,000 495,000 631,000 690,000 532,000 257,000 709,000 576,000 558,000 582,000 656,000 656,000 686,000 671,000 433,000 215,000 UPDATED 2019 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 341 788 1081 791 421 289 963 813 770 811 835 795
    [Show full text]
  • Annual Report 2019
    ANNUAL REPORT 2019 SAR Italy is a partnership between Italian higher education institutions and research centres and Scholars at Risk, an international network of higher education institutions aimed at fostering the promotion of academic freedom and protecting the fundamental rights of scholars across the world. In constituting SAR Italy, the governance structures of adhering institutions, as well as researchers, educators, students and administrative personnel send a strong message of solidarity to scholars and institutions that experience situations whereby their academic freedom is at stake, and their research, educational and ‘third mission’ activities are constrained. Coming together in SAR Italy, the adhering institutions commit to concretely contributing to the promotion and protection of academic freedom, alongside over 500 other higher education institutions in 40 countries in the world. Summary Launch of SAR Italy ...................................................................................................................... 3 Coordination and Networking ....................................................................................................... 4 SAR Italy Working Groups ........................................................................................................... 5 Sub-national Networks and Local Synergies ................................................................................ 6 Protection ....................................................................................................................
    [Show full text]
  • Boats Built at Toledo, Ohio Including Monroe, Michigan
    Boats Built at Toledo, Ohio Including Monroe, Michigan A Comprehensive Listing of the Vessels Built from Schooners to Steamers from 1810 to the Present Written and Compiled by: Matthew J. Weisman and Paula Shorf National Museum of the Great Lakes 1701 Front Street, Toledo, Ohio 43605 Welcome, The Great Lakes are not only the most important natural resource in the world, they represent thousands of years of history. The lakes have dramatically impacted the social, economic and political history of the North American continent. The National Museum of the Great Lakes tells the incredible story of our Great Lakes through over 300 genuine artifacts, a number of powerful audiovisual displays and 40 hands-on interactive exhibits including the Col. James M. Schoonmaker Museum Ship. The tales told here span hundreds of years, from the fur traders in the 1600s to the Underground Railroad operators in the 1800s, the rum runners in the 1900s, to the sailors on the thousand-footers sailing today. The theme of the Great Lakes as a Powerful Force runs through all of these stories and will create a lifelong interest in all who visit from 5 – 95 years old. Toledo and the surrounding area are full of early American History and great places to visit. The Battle of Fallen Timbers, the War of 1812, Fort Meigs and the early shipbuilding cities of Perrysburg and Maumee promise to please those who have an interest in local history. A visit to the world-class Toledo Art Museum, the fine dining along the river, with brew pubs and the world famous Tony Packo’s restaurant, will make for a great visit.
    [Show full text]
  • CONDIZIONI GENERALI GRIMALDI LINES Ed.Agosto-21 EN
    General Conditions www.grimaldi-lines.com GENERAL CONDITIONS OF CARRIAGE ON GRIMALDI LINES FERRIES - Ed. August/2021 (*) For "Events on board", the General Terms and Conditions apply, as shown at www.grimaldi-touroperator.com . Individual travel programmes can be found at www.grimaldi-lines.com . (**) For "Groups", the General Conditions communicated upon confirmation of the reservation apply. Grimaldi Group S.p.A. acts as agent for the Carrier Grimaldi Euromed S.p.A. The Carrier for the sea leg travelled is indicated on the ticket. Passengers, their luggage and accompanying vehicles are carried according to the Carrier's Terms and Conditions. By purchasing a ticket, the passenger accepts the following Covenants and Conditions. Similarly, at the time of booking and/or purchasing the ticket, the passenger authorises the processing of personal data in the manner specified in the Privacy Policy at the end of this document and in accordance with Italian Legislative Decree 196/2003. 1. DEFINITIONS. Carrier : the operator that performs the maritime transport service; Accompanying vehicle : the motor vehicle (including any towed vehicle) embarked with a passenger, used for the carriage of persons and goods not intended for sale, owned by or legally at the disposal of the passenger named on the ticket; PRM : person whose mobility is reduced, in the use of transport, due to physical disability (sensory or locomotory, permanent or temporary), mental disability or impairment, or any other cause of disability, or due to age, whose condition requires appropriate attention and adaptation of the service to meet specific needs; Service Contract : Concession contract for the public service of maritime transport of passengers, vehicles and goods between Naples, Cagliari, Palermo and vice versa, signed with the Ministry of Infrastructure and Sustainable Mobility; Lines in convention : Naples-Cagliari, Cagliari-Naples, Cagliari-Palermo, Palermo-Cagliari.
    [Show full text]
  • Communications in Computer and Information Science 452
    Communications in Computer and Information Science 452 Editorial Board Simone Diniz Junqueira Barbosa Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, Brazil Phoebe Chen La Trobe University, Melbourne, Australia Alfredo Cuzzocrea ICAR-CNR and University of Calabria, Cosenza, Italy Xiaoyong Du Renmin University of China, Beijing, China Joaquim Filipe Polytechnic Institute of Setúbal, Setúbal, Portugal Orhun Kara TÜBİTAK BİLGEM and Middle East Technical University, Ankara, Turkey Igor Kotenko St. Petersburg Institute for Informatics and Automation of the Russian Academy of Sciences, St. Petersburg, Russia Krishna M. Sivalingam Indian Institute of Technology Madras, Chennai, India Dominik Ślęzak University of Warsaw and Infobright, Warsaw, Poland Takashi Washio Osaka University, Osaka, Japan Xiaokang Yang Shanghai Jiao Tong University, Shangai, China More information about this series at http://www.springer.com/series/7899 Mireya Fernández-Chimeno • Pedro L. Fernandes Sergio Alvarez • Deborah Stacey Jordi Solé-Casals • Ana Fred Hugo Gamboa (Eds.) Biomedical Engineering Systems and Technologies 6th International Joint Conference, BIOSTEC 2013 Barcelona, Spain, February 11–14, 2013 Revised Selected Papers 123 Editors Mireya Fernández-Chimeno Jordi Solé-Casals Universitat Politècnica de Catalunya University of Vic Barcelona Victoria Spain Spain Pedro L. Fernandes Ana Fred Instituto Gulbenkian de Ciência Technical University of Lisbon Oeiras Lisbon Portugal Portugal Sergio Alvarez Hugo Gamboa Boston College New University of Lisbon Chestnut Hill, MA Lisboa USA Portugal Deborah Stacey University of Guelph Guelph Canada ISSN 1865-0929 ISSN 1865-0937 (electronic) ISBN 978-3-662-44484-9 ISBN 978-3-662-44485-6 (eBook) DOI 10.1007/978-3-662-44485-6 Library of Congress Control Number: 2014953274 Springer Heidelberg New York Dordrecht London © Springer-Verlag Berlin Heidelberg 2014 This work is subject to copyright.
    [Show full text]
  • Following Paul from Shipwreck on Malta to Martyrdom in Rome MALTA • SICILY • ITALY Led by Dr
    Following Paul from Shipwreck on Malta to Martyrdom in Rome MALTA • SICILY • ITALY Led by Dr. Carl Rasmussen MAY 11-22, 2021 organized by Following Paul from Shipwreck on Malta to Martyrdom in Rome / May 11-22, 2021 Malta Following Paul from Shipwreck on Malta to Martyrdom in Rome MAY 11-22, 2021 Fri 14 May Ferry to POZZALLO (SICILY) - SYRACUSE – Ferry to REGGIO CALABRIA Early check out, pick up our box breakfasts, meet the English-speaking assistant at our hotel and transfer to the port of Malta. 06:30am Take a ferry VR-100 from Malta to Pozzallo (Sicily) 08:15am Drive to Syracuse (where Paul stayed for three days, Acts 28.12). Meet our guide and visit the archeological park of Syracuse. Drive to Messina (approx. 165km) and take the ferry to Reggio Calabria on the Italian mainland (= Rhegium; Acts 28:13, where Paul stopped). Meet our guide and visit the Museum of Magna Grecia. Check-in to our hotel in Reggio Calabria. Dr. Carl and Mary Rasmussen Dinner at our hotel and overnight. Greetings! Mary and I are excited to invite you to join our handcrafted adult “study” trip entitled Following Paul from Shipwreck on Malta to Sat 15 May PAESTUM - to POMPEII Martyrdom in Rome. We begin our tour on Malta where we will explore the Breakfast and checkout. Drive to Paestum (435km). Visit the archeological bays where the shipwreck of Paul may have occurred as well as the Island of area and the museum of Paestum. Paestum was a major ancient Greek city Malta. Mark Gatt, who discovered an anchor that may have been jettisoned on the coast of the Tyrrhenian Sea in Magna Graecia (southern Italy).
    [Show full text]
  • Time and Material. Interdisciplinary Study for Dating St. Francesco Convent in Cagliari (XIII-XXI Century)
    Athens Journal of Architecture - Volume 2, Issue 3 – Pages 185-196 Time and Material. Interdisciplinary Study for Dating St. Francesco Convent in Cagliari (XIII-XXI Century) By Caterina Giannattasio Silvana Maria Grillo† Valentina Pintus This study concerns the Franciscan monastery, situated in the historic centre of Cagliari (Sardinia, Italy). It was founded in the 13th century, and transformed up to the present day. Its historical-stratigraphical complexity and the lack of data about its evolution led us to carry out an interdisciplinary inquiry. The investigation began with the use of a laser scanner survey aimed at defining a chronological hypothesis applied to the building which was based on reconstruction of historical maps, examination of masonry techniques and stratigraphic analyses. The dating obtained led to the choice of masonry samples to compare with other local and contemporary buildings where the chronology is well-known with the aim of confirming previous hypothesis. Analysis of the masonry samples allowed an understanding of their actual structure and composition, with reference to specific historical events. The mineralogical-petrographic characterization of building materials was essential. Plaster and mortar have been studied with instrumental techniques (OM, X-Ray diffraction) to analyze their components. The data obtained lead to a better knowledge of the Franciscan complex and this is essential for a restoration project respecting all its historical signs. The data is also very useful for dating other local buildings characterized by the same masonry techniques. Introduction This paper illustrates the results of an interdisciplinary methodology, developed by a team of researchers which involved restoration experts, surveyors and a petrographer, with the aim of obtaining a complete knowledge of the building analyzed.
    [Show full text]
  • Costa Cruises: Big News for Sicily and Sardinia
    COSTA CRUISES: BIG NEWS FOR SICILY AND SARDINIA October 11, 2019 From May 2020, the new Costa Smeralda flagship will be calling at Cagliari once a week during the summer and Palermo in winter. Costa Pacifica will also be visiting Catania during summer 2020. Genoa, October 11, 2019 – Costa Cruises announces big changes intended to further increase the company's presence in Sardinia and Sicily. The first concerns Costa Smeralda, the new flagship currently nearing completion at the Meyer shipyard in Turku, Finland. During the 2020 summer season, from May 28 to September 24, Costa Smeralda will be in Cagliari every Thursday, from 7.00 a.m. to 5.00 p.m., making a total of 18 calls. The one-week itinerary will include Savona (Saturday), Marseilles (Sunday), Barcelona (Monday), Palma de Mallorca (Tuesday), Cagliari (Thursday) and Civitavecchia (Friday). From October 1, 2020 to April 8, 2021, it will be Palermo's turn to welcome Costa Smeralda every Thursday, from 7.00 a.m. to 4.00 p.m., for a total of 28 calls. The itinerary will remain unchanged, with Palermo replacing Cagliari. In addition to Costa Smeralda, Costa Diadema will also be calling at Palermo every Tuesday from April to the end of September 2020, while during the winter of 2020/21, Costa Fortuna will arrive every Friday. Costa's calls in Palermo from January 2020 to April 2021 will therefore increase to 77 in total. The second development relates instead to Costa Pacifica. Following the changes made to the Costa Smeralda summer cruises, Costa Pacifica will stop off in Catania, instead of Cagliari, every Wednesday from June 3, 2020 to November 2020, with the following itinerary: Genoa, Barcelona, Palma de Mallorca, Malta, Catania and Civitavecchia.
    [Show full text]
  • Italy Nongeneric Names of Geographic Significance That Are Distinctive Designations of Specific Grape Wines Asti Spumante Barbar
    Italy Nongeneric names of geographic significance that are distinctive designations of specific grape wines Asti Spumante Barbaresco Barbera d’Alba Barbera d’Asti Bardolino Barolo Brunello di Montalcino Dolcetto d’Alba Frascati Gattinara Lacryma Christi Nebbiolo d’Alba Orvieto Soave Valpolicella Vino Nobile de Montepulciano Names of wines with protected designations of origin Aglianico del Taburno Equivalent term: Taburno Aglianico del Vulture Albana di Romagna Albugnano Alcamo Aleatico di Gradoli Aleatico di Puglia Alezio Alghero Alta Langa Alto Adige followed by Terlano Equivalent term: Südtirol Terlaner Alto Adige followed by Meranese di collina Equivalent term: Alto Adige Meranese / Südtirol Meraner Hügel / Südtirol Meraner Alto Adige Equivalent term: dell'Alto Adige / Südtirol / Südtiroler Alto Adige followed by Valle Isarco Equivalent term: Südtiroler Eisacktal / Eisacktaler Alto Adige followed by Valle Venosta Equivalent term: Südtirol Vinschgau Alto Adige followed by Santa Maddalena Equivalent term: Südtiroler St.Magdalener Alto Adige followed by Colli di Bolzano Equivalent term: Südtiroler Bozner Leiten Alto Adige or dell'Alto Adige whether or not followed by Burgraviato Equivalent term: dell'Alto Adige Südtirol or Südtiroler Buggrafler Alto Adige or dell'Alto Adige whether or not followed by Bressanone Equivalent term: dell'Alto Adige Südtirol or Südtiroler Brixner Ansonica Costa dell'Argentario Aprilia Arborea Arcole Assisi Asti preceded by 'Moscato di ' Atina Aversa Bagnoli di Sopra Equivalent term: Bagnoli Barbera del Monferrato
    [Show full text]
  • Clinical Practice and Epidemiology in Mental Health Biomed Central
    Clinical Practice and Epidemiology in Mental Health BioMed Central Research Open Access Needs for care among patients with schizophrenia in six European countries: a one-year follow-up study Viviane Kovess-Masféty*1, Durk Wiersma2, Miguel Xavier3, José Miguel Caldas de Almeida3, Mauro G Carta4, Jacques Dubuis5, Elisabeth Lacalmontie6, Jacques Pellet7, Jean-Luc Roelandt8, Francisco Torres- Gonzalez9, Berta Moreno Kustner9 and Dermot Walsh10 Address: 1MGEN Foundation for Public Health, EA 4069 University of Paris 5, 3 square Max Hymans, 75748 Paris Cedex 15, France, 2The Department of Social Psychiatry; University Hospital Groningen, building 32, K5.21, PO Box 30001, 9700 Groningen, The Netherlands, 3Clinica Universitaria de Psiquiatria e Saude Mental, Faculdade de Ciências Medicas, calçada da Tapada, 155, 1300 Lisboa, Portugal, 4Istituto di Clinica Psichiatrica, Università degli Studi di Cagliari, viale Merello 22, 09123 Cagliari, Italy, 5CHS Le Vinatier, 95, boulevard Pinel, 69677 Bron Cedex, France, 6CHS La Verrière, 78321 Le Mesnil St Denis, France, 7Service Universitaire de Psychiatrie Adultes, CHU St Etienne, 42055 Saint Etienne Cedex 02, France, 8Clinique Jérôme Bosch, 104, rue du Général Leclerc, BP 10, 59487 Armentières Cedex, France, 9Departamento de Psiquiatria, Facultad de Medicina, avenida de Madrid, s/n, 18071 Granada, Spain and 10Health Research Board, Holbrook House, Holles Street, Dublin 2, Ireland Email: Viviane Kovess-Masféty* - [email protected]; Durk Wiersma - [email protected]; Miguel Xavier - [email protected]; José
    [Show full text]