Pain Management

VOLUME 1 NUMBER 2 2007 Advances in PAIN MANAGEMENT Editor-in-Chief Russell Portenoy, New York, NY, USA Update on Fibromyalgia and Chronic Widespread Pain MC Hsu MD and DJ Clauw MD Sex, Gender, and Pain RB Fillingim PhD Interventional Approaches to the Diagnosis and Treatment of Low Back Pain L Manchikanti MD, MV Boswell PhD, and J Giordano PhD Interpreting Changes in State Laws and Regulations Governing the Use of Controlled Substances to Treat Pain AM Gilson PhD www.advancesinpainmanagement.com Jointly sponsored by the University of Kentucky Colleges of Pharmacy and Medicine and Remedica Medical Education and Publishing. This journal is supported by an The University of Kentucky is an equal opportunity university. educational grant from Cephalon Advances in Pain Management is supported by an educational grant from Cephalon. EDITOR-IN-CHIEF ASSOCIATE EDITOR Russell K Portenoy MD Ricardo A Cruciani MD Chairman and Gerald J and Dorothy R Friedman Chair in Vice-Chairman and Director, Research Division, Pain Medicine and Palliative Care, Department of Pain Department of Pain Medicine and Palliative Care, Medicine and Palliative Care, Beth Israel Medical Center, Beth Israel Medical Center, Assistant Professor, Professor of Neurology and Anesthesiology, Albert Departments of Neurology and Anesthesiology, Einstein College of Medicine, Chief Medical Officer, Albert Einstein College of Medicine, New York, Continuum Hospice Care, New York, NY, USA NY, USA EDITORS Lara Dhingra PhD Helena Knotkova PhD Research Psychologist, Department of Pain Medicine Research Scientist, Research Division, Department and Palliative Care, Beth Israel Medical Center, of Pain Medicine and Palliative Care, Beth Israel New York, NY, USA Medical Center, New York, NY, USA EDITORIAL ADVISORY BOARD Miroslav Backonja MD Francis Keefe PhD Professor of Neurology, Anesthesiology and Orthopedics & Professor, Department of Psychiatry and Behavioral Rehabilitation, Director of Research and Education of the Sciences, Director, Pain Prevention and Treatment Pr UW-Pain Treatment and Research Center, Medical School, Research Program, Professor of Medicine, Professor Th The University of Wisconsin, Madison, WI, USA in Anesthesiology, Duke University Medical Center, O Durham, NC, USA Peggy Compton PhD Jo Associate Professor, School of Nursing, Acute Care Jianren Mao MD Ka Section, University of California Los Angeles, Associate Professor, Director, MGH Center for an Los Angeles, CA, USA Translational Pain Research, Division of Pain Medicine, Edward C Covington PhD Department of Anesthesia and Critical Care, Director, Chronic Pain Rehabilitation, Cleveland Clinic Massachusetts General Hospital, Harvard Medical An Foundation, Cleveland, OH, USA School, Boston, MA, USA in Robert Dworkin PhD Judith A Paice PhD He Professor of Anesthesiology, Neurology, Oncology, and Director, Cancer Pain Program, Division of Hematology- Gl Psychiatry, Director, Anesthesiology Clinical Research Oncology, Northwestern University; Feinberg School of an Center, University of Rochester School Medicine, Chicago, IL, USA of Medicine and Dentistry, Rochester, NY, USA Steven D Passik PhD Ca Doug Gourlay MD Associate Attending Psychologist, Memorial Sloan Medical Consultant, Pain and Chemical Dependency Ce Kettering Cancer Center, Associate Professor of Division, The Wasser Pain Management Centre, Mount Ra Psychiatry, Weill College of Cornell Medical Center, Sinai Hospital, The Centre for Addiction Be New York, NY, USA and Mental Health, Toronto, ON, Canada Martin Grabois MD Neal Slatkin PhD Professor and Chairman, Physical Medicine and Director, Department of Supportive Care, Pain and Rehabilitation, Professor, Anesthesiology, Baylor College Palliative Medicine, Professor, Division of Medicine, of Medicine, Professor, Physical Medicine Departments of Supportive Care, Pain and Palliative and Rehabilitation, University of Texas Health Science Medicine and Neurology, City of Hope National Medical Center-Houston, Houston, TX, USA Center, Duarte, CA, USA ADVANCES IN PAIN MANAGEMENT Reader Survey – Let Us Know What You Think! Please take a few moments to complete this survey. We would value your opinion. Please photocopy this page, complete the survey below, and fax it back to Remedica on 312 372 0217. Or you can visit the ADVANCES IN PAIN MANAGEMENT website to provide feedback (registration online is FREE): www.advancesinpainmanagement.com 1. We are aiming to provide practical information for pain specialists, including anesthesiologists, neurologists, oncologists, general physicians, and primary care physicians. How would you rate the information presented in this issue? Strongly agree Strongly disagree a) The technical quality of information included in ADVANCES IN PAIN MANAGEMENT was acceptable: 12345 b) The information was relevant to my practice: 12345 c) The information was presented clearly: 12345 d) The leading articles provided new information regarding the understanding and treatment of pain management: 12345 re-Emptive Antifungal herapy ine) Neutropenic The clinical review section was helpful and I would like to see analyses in future issues: 12345 Onco-Hematology Patients han Maertens,2. Did Koen you learn Theunissen, anything through the CME activity ADVANCES IN PAIN atrien Lagrou,MANAGEMENT Tom Lodewyck,that will change the way you practice medicine? ■ Yes ■ No nd Johan VanIf Eldere so, what? ........................................................................................................................................................................................ ntifungal3. ProphylaxisIs there anything you learned from the CME activity ADVANCES IN PAIN MANAGEMENT that prompts you to seek further information that may influence the way you practice Patients withmedicine in the future? ■ Yes ■ No ematological Cancers If so, what? ........................................................................................................................................................................................ loria N Mattiuzzi nd Hagop Kantarjian4. Would you like to recommend ADVANCES IN PAIN MANAGEMENT to a colleague? ■ Yes ■ No ase Study: MyRhino-Orbito- colleague’s email is: ...................................................................................................................................................................... erebral Zygomycosis5. What specific topics do you think should be covered in future issues? aoul Herbrecht, Caroline erthillot, and ...............................................................................................................................Cécile Fohrer ............................................................................ Name ...... ............................................................................ Job title .......................................................................................... Institution .......................................................................................................................................................................................... Address ... .......................................................................................................................................................................................... ............... .......................................................................................................................................................................................... Country .. .............................................................................. Post/zip code ................................................................................. Email ....... .......................................................................................................................................................................................... RT137_2_REM_PAIN_1-2_06.qxd 8/8/07 11:59 Page 37 Dear Colleagues, Welcome to the second issue of Advances in Pain Management. Contents In our first leading article, Drs Hsu and Clauw (University of Leading Articles Michigan Medical School, Ann Arbor, MI, USA) discuss Update on Fibromyalgia and Chronic 38 fibromyalgia and chronic widespread pain, focusing on the Widespread Pain translation of the most recent concepts in pathophysiology into Michael C Hsu and Daniel J Clauw clinical practice. In addition, this article provides a comprehensive update on the clinical presentation and natural history of the Sex, Gender, and Pain 46 condition as well as a discussion on the state-of-the-art Roger B Fillingim pharmacological and non-pharmacological treatment strategies. Interventional Approaches to the Diagnosis and 54 In the second article, Dr Fillingim (University of Florida, Gainesville, Treatment of Low Back Pain: FL, USA ) explores sex differences in the experience of pain, with a Laxmaiah Manchikanti, Mark V Boswell, discussion that includes epidemiological considerations, differences and James Giordano in the response to the analgesic effect of opioids, and the clinical Interpreting Changes in State Laws and 60 implications of these differences. This topic, which is frequently Regulations Governing the Use of Controlled overlooked by the general reader, provides important insight into Substances to Treat Pain clinical practice. Aaron M Gilson In the third article, Drs Manchikanti, Boswell, and Giordano (University of Louisville, KY, USA and Georgetown University Case Report Medical Center, Washington, DC, USA) present an evidence- Successful

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