Anti- DDX17 Antibody

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anti- DDX17 antibody Product Information Catalog No.: FNab02296 Size: 100μg Form: liquid Purification: Immunogen affinity purified Purity: ≥95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: None IsoType: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) Background RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for zinc-finger antiviral protein ZC3HAV1- mediated mRNA degradation. Immunogen information Immunogen: DEAD(Asp-Glu-Ala-Asp) box polypeptide 17 Synonyms: DDX17, DEAD box protein 17, DEAD box protein p72, P72, RH70, RNA dependent helicase p72 Observed MW: 72 kDa, 80 kDa Uniprot ID : Q92841 Application Reactivity: Human, Mouse, Rat Tested Application: ELISA, IHC, IF, WB, IP 1 Wuhan Fine Biotech Co., Ltd. B9 Bld, High-Tech Medical Devices Park, No. 818 Gaoxin Ave.East Lake High-Tech Development Zone.Wuhan, Hubei, China(430206) Tel :( 0086)027-87384275 Fax: (0086)027-87800889 www.fn-test.com Recommended dilution: WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:500-1:2000; IF: 1:10-1:100 Image: Immunohistochemistry of paraffin-embedded human kidney using FNab02296(DDX17 antibody) at dilution of 1:100 Immunofluorescent analysis of Hela cells, using DDX17 antibody FNab02296 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). IP Result of anti-DDX17,P72 (IP: FNab02296, 4ug; Detection: FNab02296 1:1000) with mouse brain tissue lysate 3000ug. 2 Wuhan Fine Biotech Co., Ltd. B9 Bld, High-Tech Medical Devices Park, No. 818 Gaoxin Ave.East Lake High-Tech Development Zone.Wuhan, Hubei, China(430206) Tel :( 0086)027-87384275 Fax: (0086)027-87800889 www.fn-test.com HEK-293 tissue were subjected to SDS PAGE followed by western blot with FNab02296(DDX17 antibody) at dilution of 1:1000 3 Wuhan Fine Biotech Co., Ltd. B9 Bld, High-Tech Medical Devices Park, No. 818 Gaoxin Ave.East Lake High-Tech Development Zone.Wuhan, Hubei, China(430206) Tel :( 0086)027-87384275 Fax: (0086)027-87800889 www.fn-test.com .

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1 Supporting Information for a Microrna Network Regulates
Supporting Information for A microRNA Network Regulates Expression and Biosynthesis of CFTR and CFTR-ΔF508 Shyam Ramachandrana,b, Philip H. Karpc, Peng Jiangc, Lynda S. Ostedgaardc, Amy E. Walza, John T. Fishere, Shaf Keshavjeeh, Kim A. Lennoxi, Ashley M. Jacobii, Scott D. Rosei, Mark A. Behlkei, Michael J. Welshb,c,d,g, Yi Xingb,c,f, Paul B. McCray Jr.a,b,c Author Affiliations: Department of Pediatricsa, Interdisciplinary Program in Geneticsb, Departments of Internal Medicinec, Molecular Physiology and Biophysicsd, Anatomy and Cell Biologye, Biomedical Engineeringf, Howard Hughes Medical Instituteg, Carver College of Medicine, University of Iowa, Iowa City, IA-52242 Division of Thoracic Surgeryh, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada-M5G 2C4 Integrated DNA Technologiesi, Coralville, IA-52241 To whom correspondence should be addressed: Email: [email protected] (M.J.W.); yi- [email protected] (Y.X.); Email: [email protected] (P.B.M.) This PDF file includes: Materials and Methods References Fig. S1. miR-138 regulates SIN3A in a dose-dependent and site-specific manner. Fig. S2. miR-138 regulates endogenous SIN3A protein expression. Fig. S3. miR-138 regulates endogenous CFTR protein expression in Calu-3 cells. Fig. S4. miR-138 regulates endogenous CFTR protein expression in primary human airway epithelia. Fig. S5. miR-138 regulates CFTR expression in HeLa cells. Fig. S6. miR-138 regulates CFTR expression in HEK293T cells. Fig. S7. HeLa cells exhibit CFTR channel activity. Fig. S8. miR-138 improves CFTR processing. Fig. S9. miR-138 improves CFTR-ΔF508 processing. Fig. S10. SIN3A inhibition yields partial rescue of Cl- transport in CF epithelia.
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