Received: 30 October 2020 Revised: 6 March 2021 Accepted: 9 March 2021 DOI: 10.1002/ptr.7098 REVIEW Nutmegs and wild nutmegs: An update on ethnomedicines, phytochemicals, pharmacology, and toxicity of the Myristicaceae species Rubi Barman1,2 | Pranjit Kumar Bora1,2 | Jadumoni Saikia1 | Phirose Kemprai1,2 | Siddhartha Proteem Saikia1,2 | Saikat Haldar1,2 | Dipanwita Banik1,2 1Agrotechnology and Rural Development Division, CSIR-North East Institute of Prized medicinal spice true nutmeg is obtained from Myristica fragrans Houtt. Rest spe- Science & Technology, Jorhat, 785006, Assam, cies of the family Myristicaceae are known as wild nutmegs. Nutmegs and wild nutmegs India 2Academy of Scientific and Innovative are a rich reservoir of bioactive molecules and used in traditional medicines of Europe, Research (AcSIR), Ghaziabad, 201002, Uttar Asia, Africa, America against madness, convulsion, cancer, skin infection, malaria, diar- Pradesh, India rhea, rheumatism, asthma, cough, cold, as stimulant, tonics, and psychotomimetic Correspondence agents. Nutmegs are cultivated around the tropics for high-value commercial spice, Dipanwita Banik, Agrotechnology and Rural Development Division, CSIR-North East used in global cuisine. A thorough literature survey of peer-reviewed publications, sci- Institute of Science & Technology, Jorhat, entific online databases, authentic webpages, and regulatory guidelines found major 785006, Assam, India. Email:
[email protected] and phytochemicals namely, terpenes, fatty acids, phenylpropanoids, alkanes, lignans, flavo-
[email protected] noids, coumarins, and indole alkaloids. Scientific names, synonyms were verified with Funding information www.theplantlist.org. Pharmacological evaluation of extracts and isolated biomarkers Council of Scientific and Industrial Research, showed cholinesterase inhibitory, anxiolytic, neuroprotective, anti-inflammatory, immu- Ministry of Science & Technology, Govt.