RESEARCH Effect of dose and duration of reduction in dietary sodium on BMJ: first published as 10.1136/bmj.m315 on 24 February 2020. Downloaded from blood pressure levels: systematic review and meta-analysis of randomised trials Liping Huang,1,2 Kathy Trieu,2 Sohei Yoshimura,2,3 Bruce Neal,2,4 Mark Woodward,2,5 Norm R C Campbell,6 Qiang Li,2 Daniel T Lackland,7 Alexander A Leung,6 Cheryl A M Anderson,8 Graham A MacGregor,9 Feng J He9 For numbered affiliations see ABSTRACT 2.07 mm Hg (1.67 to 2.48, P<0.001), respectively. end of the article. OBJECTIVE Each 50 mmol reduction in 24 hour sodium excretion Correspondence to: F J He To examine the dose-response relation between was associated with a 1.10 mm Hg (0.66 to 1.54;
[email protected] reduction in dietary sodium and blood pressure P<0.001) reduction in SBP and a 0.33 mm Hg (0.04 ORCID 0000-0003-2807-4119) change and to explore the impact of intervention to 0.63; P=0.03) reduction in DBP. Reductions in Additional material is published online only. To view please visit duration. blood pressure were observed in diverse population the journal online. DESIGN subsets examined, including hypertensive and non- Cite this as: BMJ 2020;368:m315 Systematic review and meta-analysis following hypertensive individuals. For the same reduction in 24 http://dx.doi.org/10.1136/bmj.m315 PRISMA guidelines. hour urinary sodium there was greater SBP reduction Accepted: 8 January 2020 in older people, non-white populations, and those DATA SOURCES with higher baseline SBP levels.