Abhinav Grover

ABHINAV GROVER

1. Areas of specialization: Cancer Biology, Metabolic Engineering, Computational Biology

2. Address a. Correspondence: Dr. Abhinav Grover Assistant Professor School of Biotechnology, Jawaharlal Nehru University New Delhi – 110067, India b. Permanent: H. No. 532, Sec-13, Urban Estate, Kurukshetra, Haryana – 136118 Mobile: +91-8130738032 Tel: +91-11-26738728 Fax: +91-11-26702040 Email: [email protected] [email protected] 3. Date of Birth: November 03, 1985

4. Academic Qualifications: (From Class 12th Standard onwards)

Name of Percentage of Board/ Year of the Major Subjects taken Marks or University Passing Degree CGPA Physics, Chemistry, 12th Std. CBSE 2003 86.2% Maths B.Tech Indian Institute of Biochemical Engineering (Dual 2008 7.188/10 Technology Delhi and Biotechnology Degree) M.Tech Indian Institute of Biochemical Engineering (Dual 2008 7.220/10 Technology Delhi and Biotechnology Degree) Metabolic Engineering, Indian Institute of PhD 2011 Computational Biology, 8.625/10 Technology Delhi Plant Cell Technology

5. Details of Employment:

Year Position Institution

Aug 2013-Present Assistant Professor School of Biotechnology, JNU

June 2013-July 2013 Assistant Professor School of Life Sciences, JNU DST INSPIRE Aug 2012-May 2013 School of Life Sciences, JNU Faculty Cluster Innovation Centre, University of June 2012-Aug 2012 Assistant Professor Delhi Senior Project Feb 2012-June 2012 Indian Institute of Technology Delhi Scientist Aug 2011-Jan 2012 Project Scientist Indian Institute of Technology Delhi

6. Details of Professional Recognitions, Awards, and Fellowships received.

1) NASI Young Scientist Award 2014: For excellence in the field of Plant Biotechnology 2) INSA Medal for Young Scientists 2013: Country’s one of the prestigious Merit Award 3) INDUS Foundation’s Award for Research Excellence: For outstanding research (Nov 2013)

4) ICAR Jawaharlal Nehru Award 2013: For outstanding PhD Thesis

5) Bioclues Innovation and Research Development (BIRD) Award (Nov 2012) 6) DST INSPIRE Faculty Award: For carrying independent research as a faculty (Aug 2012) 7) UGC Faculty Recharge Award: UGC-sponsored faculty position (Sep 2012) 8) APBioNet Travel Fellowship: For presenting paper at InCoB in Malaysia (Dec 2011)

9) Indo-Swiss Joint Research Fellowship: To carry PhD collaborative work (May 2011)

10) DAAD Fellowship: To pursue German PhD mobility program (March 2011) 11) INSA and CSIR travel award: To give a talk in PepCon conference in China (March 2011) 12) DBT travel award: To present paper in Keystone conference in USA (Feb 2011) 13) DST travel award: To present two papers in InCoB conference in Japan (Oct 2010)

14) Ministry of HRD Scholarship: Awarded for continued academic excellence (2007-2008)

15) GATE: Achieved distinction with an All India Rank 18 (2007) 16) French Embassy Scholarship: Awarded to pursue internship in France (2006) 17) Summer Research Award: IIT Delhi's one of the best merit Academic Award (2005) 18) IIT JEE: All India Rank 1390 (2003) 19) Physics Olympiad: Top 10% in National Exam conducted by Indian Asso. of Phy. (2003) 20) Chemistry Olympiad: Invited in the National event conducted by TIFR (2003) 21) Mathematics Olympiad: Represented state at National level (2001)

22) Society of Biological Chemists, India: Life2 Member 23) International Society for Computational Biology: Member

24) Indian Science Congress Association: Life Member

7. Full List of Publications

Total No. of Research Publications: 45 Book chapters: 2 Cumulative Impact Factor: ~110 Citations: ~272 h-Index: 9 Peer-reviewed Publications in International Journals: (*Corresponding author) 1. Tyagi C, Bathke J, Goyal S, Fischer M, Dahse HM, Chacko S, Becker K, Grover A* (2015) Targeting the intersubunit cavity of Plasmodium falciparum glutathione reductase by a novel natural inhibitor: Computational and experimental evidence. International Journal of Biochemistry and Cell Biology 61:72-80 2. Gupta A, Jain R, Wahi D, Goyal S, Jamal S and Grover A* (2015) Abrogation of AuroraA-TPX2 by novel natural inhibitors: Molecular dynamics based mechanistic analysis. Journal of Receptors and Signal Transduction (Accepted) 3. Maindola P, Jamal S and Grover A* (2015) Cheminformatics based machine learning models for AMA1-RON2 abrogators for inhibiting Plasmodium falciparum erythrocyte invasion. Molecular Informatics (Accepted) 4. Wahi D, Jamal S, Goyal S, Singh S, Jain R, Rana P and Grover A* (2015) Cheminformatics models based on machine learning approaches for design of USP1/UAF1 abrogators as anticancer agents. Systems and Synthetic Biology DOI 10.1007/s11693-015-9162-1 5. Vats C, Gupta A, Dhanjal JK, Goyal S, Bharadvaja N and Grover A* (2015) Mechanistic analysis elucidating the relationship between Lys96 mutation in Mycobacterium tuberculosis pyrazinamidase enzyme and pyrazinamide susceptibility. BMC Genomics 16(S2):S14. 6. Gupta A, Jamal S, Goyal S, Jain R, Wahi D and Grover A* (2015) Structural studies on molecular mechanisms of Nelfinavir resistance caused by non-active site mutation V77I in HIV-1 protease. BMC Bioinformatics (Accepted). 7. Dhanjal JK, Sharma S, Grover A and Das A* (2015) Use of ligand based pharmacophore modeling and docking approach to find novel acetylcholinesterase inhibitors for treating Alzheimer’s. Biomedicine and Pharmacotherapy 71:146-152 8. Goyal S, Jamal S, Shanker A and Grover A* (2015) Structural investigations of T854A mutation in EGFR and identification of novel inhibitors using structure activity relationships. BMC Genomics (Accepted) 9. Raj N, Helen A, Manoj N, Harish G, Thomas V, Singh S, Sehrawat S, Seth S, Nair AS, Grover A and Dhar PK* (2015) In silico study of peptide inhibitors against BACE 1 Systems and Synthetic Biology DOI 10.1007/s11693-015-9169-7 10. Dhanjal JK, Grover S, Sharma S, Singh AK and Grover A* (2014) Structural insights into mode of actions of novel natural Mycobacterium protein tyrosine phosphatase B inhibitors. BMC Genomics 15(S1):S3 3

11. Tyagi C, Gupta A, Goyal S, Dhanjal JK and Grover A* (2014) Fragment based group QSAR and molecular dynamics mechanistic studies on arylthioindole derivatives targeting the α-β interfacial site of human tubulin. BMC Genomics 15(S7):S6 12. Vats C, Dhanjal JK, Goyal S, Bharadvaja N and Grover A* (2014) Computational design of novel flavonoid analogues as potential AChE inhibitors: analysis using group- based QSAR, molecular docking and molecular dynamics simulations. Structural Chemistry doi: 10.1007/s11224-014-0494-3 13. Goyal S, Dhanjal JK, Tyagi C, Goyal M and Grover A* (2014) Novel fragment-based QSAR modelling and combinatorial design of pyrazole derived CRK3 inhibitors as potent anti-leishmanials. Chemical Biology and Drug Design 84(1):54-62 14. Goyal S, Grover S, Dhanjal JK, Goyal M, Tyagi C, Chacko S and Grover A* (2014) Mechanistic insights into mode of actions of novel oligopeptidase B inhibitors for combating leishmaniasis. Journal of Molecular Modeling 20(3):2099 15. Soni S, Tyagi C, Grover A* and Goswami A* (2014) Molecular modeling and molecular dynamics simulations based structural analysis of the SG2NA protein variants. BMC Research Notes 7:446 16. Goyal M, Dhanjal JK, Goyal S, Tyagi C, Hamid R and Grover A* (2014) Development of dual inhibitors against Alzheimer’s disease using fragment-based QSAR and molecular docking. Biomed Research International Article ID 979606 17. Grover S, Dhanjal JK, Goyal S, Grover A and Sundar D (2014) Computational identification of novel natural inhibitors of glucagon receptor for checking type II diabetes mellitus. BMC Bioinformatics 15(S16):S3 18. Dhanjal JK, Grover S, Paruthi P, Sharma S and Grover A* (2014) Mechanistic insights into mode of action of a potent natural antagonist of orexin receptor-1 by means of high throughput screening and molecular dynamics simulations. Combinatorial Chemistry & High Throughput Screening 17(2):124-31 19. Dhanjal JK, Nigam N, Sharma S, Chaudhary A, Kaul SC, Grover A*, Wadhwa R* (2014) Embelin inhibits TNF-alpha converting enzyme and cancer cell metastasis: molecular dynamics and experimental evidence. BMC Cancer 14:775 20. Patel K, Tyagi C, Goyal S, Dhanjal JK, Bharadvaja N, Grover A* (2014) Curcumin- based IKKβ inhibiting anticancer lead design using novel fragment based group QSAR modeling. Medicinal Chemistry Research DOI 10.1007/s00044-014-1274-8 21. Dhanjal JK, Goyal S, Sharma S, Hamid R and Grover A*. (2013) Mechanistic insights into mode of action of potent natural antagonists of BACE-1 for checking Alzheimer’s plaque pathology. Biochemical and Biophysical Research Communications 443(3):1054-9 22. Goyal M, Grover S, Dhanjal JK, Goyal S, Tyagi C and Grover A* (2013) Molecular modeling studies on flavonoid derivatives as dual site inhibitors of human acetyl cholinesterase using 3D-QSAR, pharmacophore and high throughput screening approaches. Medicinal Chemistry Research 23(4):2122-2132

23. Goyal M, Grover S, Dhanjal JK, Goyal S, Tyagi S, Chacko S and Abhinav Grover* (2013) Novel natural structure corrector of ApoE4 for checking Alzheimer's disease. Benefits from high throughput screening and molecular dynamics simulations. Biomed Research International, Article ID 620793 doi:10.1155/2013/620793 24. Tyagi C, Grover S, Dhanjal JK, Goyal S, Goyal M and Grover A* (2013) Mechanistic insights into mode of action of novel natural cathepsin L inhibitors. BMC Genomics 14(S8):S10 25. Saxena N, Katiyar SP, Liu Y, Grover A et al. (2013) Molecular interactions of Bcl-2 and Bcl-xL with mortalin: identification and functional characterization. Bioscience reports 33(5):797-806 26. Grover A et al. (2013) Enhanced withanolide production by overexpression of squalene synthase in Withania somnifera. Journal of Bioscience and Bioengineering 115(6):680-705 27. Dhiman H, Dhanjal JK, Sharma S, Chacko S and Grover A* (2013) Resisting resistant Mycobacterium tuberculosis naturally: Mechanistic insights into the inhibition of the parasite's sole signal peptidase Leader peptidase B. Biochemical and Biophysical Research Communications 433(4):552-7 28. Grover A et al. (2012) Ashwagandha derived withanone targets TPX2-Aurora A complex: Computational and experimental evidence to its anticancer activity. Plos One 7(1) e30890 29. Grover A et al. (2012) Withanone binds to mortalin and abrogates p-53 complex: computational and experimental evidence. International Journal of Biochemistry and Cell Biology 44:496-504 30. Grover A et al. (2012) Computational evidence to inhibition of human acetyl cholinesterase by withanolide A for Alzheimer treatment. Journal of Biomolecular Structure and Dynamics 29(4):651-662 31. Grover A et al. (2012) Epitopic analysis of potential vaccine candidate in Leishmania infantum for development of human vaccine. Letters in Drug Design and Discovery 9:698-705 32. Grover A et al. (2012) A leishmaniasis study: Structure-based screening and molecular dynamics mechanistic analysis for discovering potent inhibitors of spermidine synthase. BBA: Proteins and Proteomics 1824(12):1476-1483 33. Grover A et al. (2012) Mechanistic insights into the dual inhibition strategy for checking leishmaniasis. Journal of Biomolecular Structure and Dynamics 30(4) 439- 452 34. Grover A et al. (2012) Blocking Protein kinase C signaling pathway: mechanistic insights into the anti-leishmanial activity of prospective herbal drugs from Withania somnifera. BMC Genomics 13(S7):S20 35. Sarkar A, Kumar S, Grover A et al. (2012) Protein aggregation and neurodegenerative diseases: Insights from computational analyses. Current Bioinformatics 7(1):87-95 5

36. Grover A et al. (2011) Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: Mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin-A. BMC Bioinformatics 12(S13):S22 37. Grover A et al. (2011) Production of monoterpenoids and aroma compounds from cell suspension cultures of Camellia sinensis. Plant Cell Tissue and Organ Culture 108:323-331 38. Grover A et al. (2011) Hsp90/Cdc37 Chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A. BMC Bioinformatics 12(S1):S30 39. Grover A et al. (2011) Blocking the chaperone kinome pathway: Mechanistic insights into a novel dual inhibition strategy for supra-additive suppression of malignant tumors. Biochem Biophys Res Comm 404(1):498-503 40. Grover A et al. (2010) Re-programming DNA-binding specificity in zinc finger proteins for targeting unique address in a genome. Systems and Synthetic Biology 4(4):323-329 41. Sharma A, Punetha A, Grover A et al. (2010) Insights into the key enzymes of secondary metabolite biosynthesis in Camellia sinensis. J Bioinf Seq Anal 2(5):53-68. 42. Grover A, Grover A et al. (2010), Identification of Ralstonia solanacearum Yabuchi et al. using conserved genomic regions. IJBMBR 2(1):23-30 43. Grover A et al. (2010) Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera’s key metabolite withaferin A. BMC Genomics 11(S4):S25 44. Grover A et al. (2010) Probing the anticancer mechanism of prospective herbal drug Withaferin A on mammals: a case study on human and bovine proteasomes. BMC Genomics 11(S4):S15 45. Grover A et al. (2005) Predicting alternate structure attainment and amyloidogenesis: A nonlinear signal analysis approach. Biochem Biophy Res Comm 338(3):1410-6

Peer-reviewed Book chapters 1. Grover A, Shandilya A, Agrawal V, Bisaria VS and Sundar D (2011) Computational insights in to the binding mechanisms of herbal anticancer drugs. In: Bioinformatics – Genome Bioinformatics and Computational Biology, Tuteja, R. (Ed.)., Nova Science Publishers Inc., Hauppauge, NY, USA. ISBN: 978-1-62100-913-9 (In Press) 2. Sarkar A, Kumar S, Punetha A, Grover A and Sundar D (2010) Analysis and prediction of DNA-recognition by zinc finger proteins: applications in genome modification. In: Biomedical Engineering and Information Systems: Technologies, Tools and applications, Shukla, A. and Tiwari, R. (Eds.) , pp. 303-317, IGI Global, Hershey, PA, USA

8. Details of Professional Training and Research Experience

 International Scientific Instrument Technology Workshop (ISITW) Instrument Training Research Centre, Hsinchu, Taiwan (October 2011) Featured the application of instrument technology in Nano, Bio and Green technology. Over twenty sessions of lectures conducted by professionals worldwide were presented in the two-week program along with hands-on sessions.

 International Scientific Instrument Technology Workshop (ISITW) Instrument Training Research Centre, Hsinchu, Taiwan (October 2009) Provided a precious opportunity for researchers in Nanobiology and Biosensors to absorb and exchange the latest research progress of the field

 Bio-pharmaceutical investigations on novel drug delivery systems for oral administration of drugs Ian Wark research Institute, Adelaide, Australia (May 2007 - July 2007) Project involved physico-chemical characterization of nanoparticle coated emulsions for improved drug delivery followed by in vivo studies to study bioavailability of novel formulations. Achievements: Sound knowledge about pharma sector and drug delivery mechanisms; Exposure to industry.

9. Details of participation in conferences/symposiums 1) BioEpoch 2015 Apr 2015, Jawaharlal Nehru University, New Delhi 2) National Workshop cum Training Program on Drug Design and Discovery (Invited Talk) Mar 2015, Institute of Life Sciences, Bhubaneswar 3) Indian Science Congress (Oral Presentation) Jan 2015, Mumbai University, Mumbai 4) BioAsia 2015 Feb 2015, HICC, Hyderabad 5) Biotikos 2015 - Current Techniques and Development in Bioinformatics (Invited Talk) Jan 2015, TERI University, New Delhi 6) Workshop on flow cytometry and its applications Aug 2014, NIOP, New Delhi, India 7) International Conference on Bioinformatics (Invited Talk) July 2014, Sydney, Australia

8) Conference on Managing Genotoxic Impurities: Experience, exchange and solutions, June 2014, Holiday Inn, Pune 9) HPC User Workshop May 2014, Inter University Accelerator Centre, New Delhi 10) BioEpoch 2014 Apr 2014, Jawaharlal Nehru University, New Delhi 11) Training Program in Bioinformatics (Invited Talk) Feb 2014, DBEB, IIT Delhi 12) Asian Congress on Biotechnology (ACB 2013) Dec 2013, Indian Habitat Centre, New Delhi 13) Indo-US Symposium on Botanical Drug Development Dec 2013, Medanta, New Delhi 14) 85th ICAR Foundation Day and Award Ceremony July 2013, NASC, New Delhi 15) National workshop on Drug Design and Discovery Feb 2013, Institute of Life Sciences, Bhubaneswar 16) Asian Young Researcher Conference on Bioinformatics (AYRCOB) 2012 (Invited Talk) Dec 2012, Shenzhen, China 17) International Conference on Bioinformatics (InCoB) 2011 (Oral Presentation) Dec 2011, Kuala Lumpur, Malaysia 18) 80th Annual meeting of SBC (Oral Presentation) Oct 2011, CIMAP, Lucknow 19) International Scientific Instrument Technology Workshop 2011 Oct 2011, Instrument Training Research Centre, Hsinchu, Taiwan 20) PepCon 2011 (Protein and Peptide Conference - Young Scientist talk) Mar 2011, Beijing, China 21) Keystone Symposia (Cancer control by tumor suppressors) Feb 2011, Santa fe, New Mexico, US 22) APBC 2011 (Asia Pacific Bioinformatics Conference) Jan 2011, Incheon, Korea 23) Indo-Japan bilateral meet IIT Delhi, New Delhi, India 24) Indo-Swiss Joint Bioinformatics symposium IIT Delhi, New Delhi, India 25) InCoB’10 (International Conference on Bioinformatics) Waseda University, Tokyo, Japan 26) AROMED 2010) CIMAP, Lucknow, India 8

27) International Scientific Instrument Technology Workshop 2009 Oct 2009, Instrument Training Research Centre, Hsinchu, Taiwan