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This report is prepared according to the 2013 fiscal year of the RoyalThai Government, from 1 October 2012 - 30 September 2013. First Edition January 2014 Number of copies printed 400 Copyright © 2014 by National Center for Genetic Engineering and Biotechnology (BIOTEC) National Science and Technology Development Agency (NSTDA) Annual Report 2013 National Center for Genetic Engineering and Biotechnology/National Center for Genetic Engineering and Biotechnology. National Science and Technology Development Agency (NSTDA). -- Pathum Thani: National Center for Genetic Engineering and Biotechnology, 2014. 79 p. ISBN: 978-616-12-0317-7 1. Biotechnology 2. Genetic Engineering I. National Center for Genetic Engineering and Biotechnology TP248.2 660.6 Published by National Center for Genetic Engineering and Biotechnology (BIOTEC) National Science and Technology Development Agency (NSTDA) Ministry of Science and Technology 113 Thailand Science Park, Phahonyothin Road, Khlong Nueng, Khlong Luang, Pathumthani 12120 THAILAND Tel: +66 (0) 2564 6700 Fax: +66 (0) 2564 6701-5 Website: http://www.biotec.or.th CONTENTS 05 Message from the BIOTEC Executive Director 06 Celebrating 30 Years of BIOTEC 10 Facts and Figures 14 Research and Development 46 Commercialization and Private Sector Partnership 50 Human Resources Development 54 Public Awareness 56 International Collaboration 60 Impact of BIOTEC’s Output 64 Appendices 65 List of Publications 74 List of Intellectual Properties 77 Honors and Awards 79 Executives and Management Team Message from the BIOTEC Executive Director Celebrating 30 Years of BIOTEC In March 2013 the Thai government’s Rice Department the agriculture and food industry of Thailand during a time announced the certification of flood-tolerant jasmine rice when GMO-free products were in need of verification. The and named it “RD51”. It was the first rice variety developed laboratory has likewise made a significant impact on the from BIOTEC’s molecular rice breeding program to ever be Thai rice industry by authenticating Thai jasmine rice to certified. In addition, another variety, RD18, a blast-resistant enable it to command premium prices in domestic and glutinous rice, was recently certified in August. Both varieties international markets. With the expertise of our research team and many more in the pipeline are the result of over two decades on shrimp disease, we were able to protect the shrimp farming of dedication by our rice research team in implementing industry from disease outbreaks in the late 1990s through marker-assisted selection technology in this breeding program. the introduction of molecular diagnostic tools for important pathogens. With regard to scientific excellence, Prof. Yongyuth In 1982, the Thai Government tendered a bid to host a UNIDO In September, the Agricultural Research Development Agency Yuthavong, the former BIOTEC Executive Director and an international centre for genetic engineering and biotechnology. (Public Organization) unveiled oil palm plant lines that were avid scientist in antimalarial drug development, and his team developed by a BIOTEC research team, in collaboration made a breakthrough discovery of the crystal structures of The attempt was unscuccesful. Nevertheless, recognizing the with Kasetsart University, Prince of Songkla University, the a primary malarial drug target, dihydrofolate reductase, in potential of biotechnology, the Government decided to found Department of Agriculture and Golden Tenera Co., Ltd. These 2003, opening new frontiers for malarial drug design. Now elite lines were developed for the Thai climate, especially that one of the compounds against this drug target designed by the National Center for Genetic Engineering and Biotechnology of the north and northeastern regions where humidity and the team, P218, is being pre-clinically tested. (BIOTEC) in 1983. rainfall are limited. Production of seedlings is underway, with 100,000 seedlings expected to be released in the next few These are just a few examples of past success stories which years. These lines are expected to make a significant impact we hope will serve as a motivating force for our staff for the on oil palm production and make a major contribution to the next chapter of BIOTEC. food and fuel sectors of the Thai economy. BIOTEC also celebrated the 30th anniversary of its establish- ment in September of this year. The Center has come a long way, from having two staff and a budget of less than one hundred thousand US$ to promote biotechnology research -- to an organization with 570 staff members and an operating fund of over US$ 20 million annually. Several major contributions have been made to the nation during these past 30 years. Dr. Kanyawim Kirtikara BIOTEC established the first DNA testing laboratory to serve Executive Director, BIOTEC • BIOTEC Yothi Research Unit, the first in-house research unit, is founded. • BIOTEC Culture Collection (BCC) is established to serve as a central facility to collect and maintain microorganisms and their relevant data, as well as a repository of patent-related microorganisms of Thailand • BIOTEC research team BioSafety Program is Department of Intellectual discovers the crystal established to build up the Property. structures of a primary nation’s infrastructure and malarial drug target, technical capability in safety • BIOTEC launches Biotechnology for Rural Development Program, dihydrofolate reductase, The Royal Thai Government assessment of products providing new approaches Following a cabinet resolution, launches the Science and derived from genetic to use biotechnology to enhance the development of rural for the anti-malarial drug the National Center for Genetic Technology Scholarship Program, modification technology, design. Engineering and Biotechnology supporting talented students as well as enhancing communities. BIOTEC joins the International (BIOTEC) is established under the to study in foreign countries biosafety management and • BIOTEC, in collaboration with Rice Genome Sequencing The Human Resource Development • The National Biotechnology Ministry of Science, Technology from undergraduate level to regulation. National biosafety several organizations, pushes Project (IRGSP), a consortium Program in Biotechnology is Policy Committee is and Energy on 20 September doctoral degree in five areas: guidelines for both laboratory forward the establishment of of publicly funded laboratories lauched, providing training established with the Prime 1983 with the aim, at that time, biotechnology, materials science, work and field testing are the National Food Institute (NFI) from 10 countries, paving the scholarships to young researchers Minister serving as the to support biotechnology research computer science, nanotechnology released, marking the first in under the purview of the Ministry way to the development of Thai from Cambodia, Laos, Myanmar chairperson and BIOTEC in various public organizations. and technology management. Thailand and the region. of Industry. rice utilizing genomic data. and Vietnam (CLMV). as the secretariat. 1983 1990 1992 1996 1999 2001 2003 2005 1985-1986 1991 1995 1997 2000 2002 2004 To promote and strengthen • As the interest in biotechnology • DNA Fingerprint Laboratory is established • The first patent titled To facilitate the coordination and • BIOTEC headquarters and Thailand’s first National biotechnology research, BIOTEC grew, it was realized that the in collaboration with Kasetsart University to “Methodology for management of bioresources in in-house laboratories are Biotechnology Policy sets up four collaborative research country still lacked the develop and set the standards for DNA immobilization of cells, Thailand, the Thailand Biodiversity relocated to Thailand Science Framework is announced, units jointly with universities: convenience of procuring fingerprinting, a technique vital to breeding enzymes or bioreactive Center (TBC) is established under a Park, Pathum Thani. setting a roadmap for biological materials and programs, genetic identification, seed purity substances to fiber threads” decree approved by the Prime Minister, biotechnology R&D and • Plant Genetic Engineering services necessary for research tests and forensic science. In 1999, the unit is issued to a BIOTEC-funded within the organizational framework of • The first transgenic papaya bio-business promotion Unit at Kasetsart University, activities. BIOTEC thus is renamed DNA Technology Laboratory, project on 18 June 1997. NSTDA. TBC activities are transferred resistant to ringspot virus is from 2004 to 2009. Kamphaengsaen Campus; establishes the BioService Unit providing services based on DNA to the newly-established Ministry of achieved through the • Thailand Tropical Diseases collaboration of BIOTEC • Microbial Genetic Engineering to provide services in biological fingerprinting and DNA sequencing Natural Resources and Environment analysis and synthesis using techniques such as genetic identity Research Programme (T-2) in 2002. and Kasetsart University. Unit at Mahidol University, is established under the Salaya Campus; modern, advanced instruments determination, genetic authentification, and technologies. DNA marker development, DNA sequencing inter-agency cooperation and • Biochemical Engineering and of plants, animals and microorganisms and participation of BIOTEC, the Pilot Plant Research and • The National Science and also GMO testing of food and feed. Thailand Research Fund (TRF) Development Unit (BEC) at Technology Development and The Special
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