United States Patent (19) 11 Patent Number: 6,071,970 Mueller Et Al

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United States Patent (19) 11 Patent Number: 6,071,970 Mueller Et Al USOO607 1970A United States Patent (19) 11 Patent Number: 6,071,970 Mueller et al. (45) Date of Patent: Jun. 6, 2000 54) COMPOUNDS ACTIVE ATA NOVELSITE WOA 93 ON RECEPTOR-OPERATED CALCUM O4373 3/1993 WIPO. CHANNELS USEFUL FOR TREATMENT OF 9521612 8/1995 WIPO. NEUROLOGICAL DISORDERS AND 9605818 2/1996 WIPO. DISEASES 964OO97 12/1996 WIPO. OTHER PUBLICATIONS 75 Inventors: Alan L. Mueller, Salt Lake City; Manuel F. Balandrin, Sandy; Marcusson, Jan O., et al., “Inhibition of Hparoxetine Bradford C. VanWagenen, Salt Lake binding by various Serotonin uptake inhibitors: Structure City; Eric G. DelMar, Salt Lake City; activity-relationships”, European Journal of Pharmacol Scott T. Moe, Salt Lake City; Linda D. ogy, 215, 1992, 191-198. Artman, Salt Lake City; Robert M. Chemical Abstracts, vol. 69, 1968, p. 3322. Barmore, Salt Lake City, all of Utah Chemical Abstracts, vol. 67, 1967, p. 3059. 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No. 08/288,668, Aug. 9, 1994, abandoned, which is a Ginsberg and Busto, Rodent Models of Cerebral Ischemia, continuation-in-part of application No. 08/194.210, Feb. 8, Stroke, 20:1627, 1989. 1994, abandoned, which is a continuation-in-part of appli Karpiak et al., “Animal Models for the Study of Drugs in cation No. 08/014,813, Feb. 8, 1993, abandoned. Ischemic Stroke', Ann. Rev. Pharmacol. Toxicol, 29:403, 51) Int. Cl." ........................ A61K31/135; CO7C 211/03 1989. 52 U.S. Cl. .......................... 514/648; 514/183; 514/210; Willetts et al., “The Behavioral Pharmacology of NMDA 514/212; 514/315; 514/408; 514/428; 514/645; Receptor Antagonists' Trends Pharmacol. 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