CSHL Undergraduate Research Program Participants 1959 - 2018
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Genome Mapping / Human Genome Project
EthxWeb Search Results Search Detail: Result=(((AV.PT.) AND ("15.10"[PC])) OR ((("15.10"[PC]) AND (B.PT.)) AND (@YD > "19991231"))) OR (((("15.10"[PC] ) AND (Y.BL.)) NOT (LETTER.TI.)) AND (@YD > "19991231")) 2=1 : " Documents: 1 281 of 281 Document 1 Lifton, Richard P. Individual genomes on the horizon. [editorial] New England Journal of Medicine 2010 April 1; 362(13): 12351236 Georgetown users check Georgetown Journal Finder for access to full text http://content.nejm.org/content/vol362/issue13/ (link may be outdated) Document 2 Lumley, Thomas; Rice, Kenneth Potential for revealing individuallevel information in genomewide association studies. JAMA: The Journal of the American Medical Association 2010 February 17; 303(7): 659660 Georgetown users check Georgetown Journal Finder for access to full text http://jama.amaassn.org/content/vol303/issue7/ (link may be outdated) Document 3 Via, Marc; Gignoux, Christopher; Burchard, Esteban González The 1000 Genomes Project: new opportunities for research and social challenges Genome Medicine [electronic] 2010 January 21; 2(1): 3p. Accessed: http://genomemedicine.com [2010 February 24] Georgetown users check Georgetown Journal Finder for access to full text http://genomemedicine.com (link may be outdated) Document 4 Marturano, Antonio When speed truly matters, openness is the answer. Bioethics 2009 September; 23(7): 385393 Abstract: In this paper I analyse the ethical implications of the two main competing methodologies in genomic research. I do not aim to provide another contribution from the mainstream legal and public policy perspective; rather I offer a novel approach in which I analyse and describe the patentandpublish regime (the proprietary regime) led by biologist J. -
Evolution of Coenzyme BI2 Synthesis Among Enteric Bacteria
Copyright 0 1996 by the Genetics Society of America Evolution of Coenzyme BI2Synthesis Among Enteric Bacteria: Evidence for Loss and Reacquisition of a Multigene Complex Jeffrey G. Lawrence and John R. Roth Department of Biology, University of Utah, Salt Lake City, Utah 84112 Manuscript received June 16, 1995 Accepted for publication October 4, 1995 ABSTRACT We have examined the distribution of cobalamin (coenzyme BI2) synthetic ability and cobalamin- dependent metabolism among entericbacteria. Most species of enteric bacteria tested synthesize cobala- min under both aerobic and anaerobic conditions and ferment glycerol in a cobalamindependent fashion. The group of species including Escha'chia coli and Salmonella typhimurium cannot ferment glyc- erol. E. coli strains cannot synthesize cobalamin de novo, and Salmonella spp. synthesize cobalamin only under anaerobic conditions. In addition, the cobalamin synthetic genes of Salmonella spp. (cob) show a regulatory pattern different from that of other enteric taxa tested. We propose that the cobalamin synthetic genes, as well asgenes providing cobalamindependent diol dehydratase, were lostby a common ancestor of E. coli and Salmonella spp. and were reintroduced as a single fragment into the Salmonella lineage from an exogenous source. Consistent with this hypothesis, the S. typhimurium cob genes do not hybridize with the genomes of other enteric species. The Salmonella cob operon may represent a class of genes characterized by periodic loss and reacquisition by host genomes. This process may be an important aspect of bacterial population genetics and evolution. OBALAMIN (coenzyme BIZ) is a large evolution- The cobalamin biosynthetic genes have been charac- C arily ancient molecule ( GEORGOPAPADAKOUand terized in S. -
Spontaneous Tandem Genetic Duplications in Salmonella
Proc. Nati. Acad. Sci. USA Vol. 78, No. 5, pp. 3113-3117, May 1981 Genetics Spontaneous tandem genetic duplications in Salmonella typhimurium arise by unequal recombination between rRNA (rrn) cistrons (gene duplication/chromosomal merodiploidy/transposon) PHILIP ANDERSON* AND JOHN ROTH Department of Biology, University of Utah, Salt Lake City, Utah 84112 Communicated by Sydney Brenner, January 19, 1981 ABSTRACT A method is described to detect and measure the quences cause duplications to arise frequently in this region of frequency of spontaneous tandem genetic duplications located the chromosome. A preliminary account of this work has ap- throughout the Salmonella genome. The method is based on the peared elsewhere (3). ability of duplication-containing strains to inherit two selectable alleles of a single gene during generalized transductional crosses. MATERIALS AND METHODS One allele of the gene carries an insertion of the translocatable Media and Growth Conditions. The details of media, sup- tetracycline-resistance element TnlO; the other allele is a wild- plements, and growth conditions have been-described (4). Tet- type copy of that gene. Using this technique, we have measured racycline and kanamycin were added at 10 pug/ml and 50 ug/ the frequency oftandem duplications at 38 chromosomal sites and ml, respectively. the amount of material included in 199 independent duplications. Bacterial Strains. All strains are derivatives of Salmonella These results suggest that, in one region of the chromosome, tan- typhimurium strain LT2. A nonlysogenizing derivative of the dem duplications are particularly frequent events. Such duplica- high-transducing phage ofSchmieger (5), P22 HT105/1 int-201, tions have end points within rRNA (rrn) cistrons and probably was used in all transductions. -
CCR for Online
COOL CAREER ROUNDTABLES 1:00 - 1:45 Female STEM Experts in Engineering. It’s a Girl Thing! LOCATION: N 103 Whether you prefer high heels or flats, there is no need to hide your secret passion for structures, machines and how things work. Learn where these women have gone with engineering degrees. Kristine Budill, MS MIT Electrical Engineering; MS MIT Management; New York Teaching Certification, Manhattan College 2012; BS Yale, Electrical Engineering Current: Director of EE Ford Program in Architecture, Design and Engineering at School of the Holy Child Previous: aircraft engine design, testing & manufacturing; Injection Molding; Fluid Technology. Sheila Narayanan, MBA, University of Chicago; BS University of Wales, Mechanical Engineering Current: Vice President, Integrated Solutions/Future Capabilities, MasterCard Worldwide; working to use data and predictive analytics to deliver leading edge payment & information services to consumers and businesses Previous: Designing jet engines for military aircraft at Rolls Royce & GE Advanced Biological Research LOCATION: N 104 Cutting edge research that cuts across disciplines -- molecular genetics, neuroscience and microbiology. Gord Fishell, PhD University of Toronto, Neurobiology; BS University of Toronto, Physiology & Biophysics Current: NYU Neuroscience Institute, NYU Langone Medical Center, Physiology & Cell Biology; Director of Fishell Lab; research includes using mice to study and map cortical microcircuits & their genetic expressions John Roth, PhD Johns Hopkins University, Biology (Genetics); -
F: Acknowledgements
Appendix F Acknowledgements OTA wishes to acknowledge the many people con- James E. Bowman tributed to the preparation of this report. Members of University of Chicago the advisory panel and contractors are listed at the Elbert Branscomb front of the report. Workshop participants are listed Lawrence Livermore National Laboratory in appendix C. Others helped by commenting on drafts Douglas Brutlag of the report, providing information or advice, or con- Stanford University senting to interviews with OTA staff. OTA particularly thanks those at the National Institutes of Health, the Martin Buechi Department of Energy, the National Science Founda- Embassy of Switzerland tion, the Howard Hughes Medical Institute, and other John Burris organizations for their invaluable efforts to inform National Academy of Sciences OTA about their activities. Our gratitude is extended to: Andrew Bush Carlos Abella U.S. Senate Embassy of Spain Mark Cantley Bruce M. Alberts Commission of the European Economic Community University of California al San Francisco Charles R. Cantor Duane Alexander College of Physicians and Surgeons of National Institute of Child Health and Human Columbia University Development C. Thomas Caskey Norman Anderson Baylor College of Medicine Large Scale Biology James Cassatt Wyatt Anderson National Institute of General Medical Sciences University of Georgia James W. Chamberlain David G. Baldwin U.S. Embassy, Brazil Tetrarch Inc. Andrew T. L. Chen David Baltimore Centers for Disease Control Whitehead Institute James F. Childress Phil Beachy University of Virginia Carnegie Institution of Washington George M. Church George I. Bell Harvard University Medical School Los Alamos National Laboratory Mary Clutter Celeste Berg National Science Foundation Carnegie Institution of Washington Stanley Cohen Fred Bergmann Stanford Medical School National Institute of General Medical Sciences Francis Collins Michel Bernon University of Michigan Embassy of France P. -
Annual Scientific Report 2011 Annual Scientific Report 2011 Designed and Produced by Pickeringhutchins Ltd
European Bioinformatics Institute EMBL-EBI Annual Scientific Report 2011 Annual Scientific Report 2011 Designed and Produced by PickeringHutchins Ltd www.pickeringhutchins.com EMBL member states: Austria, Croatia, Denmark, Finland, France, Germany, Greece, Iceland, Ireland, Israel, Italy, Luxembourg, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland, United Kingdom. Associate member state: Australia EMBL-EBI is a part of the European Molecular Biology Laboratory (EMBL) EMBL-EBI EMBL-EBI EMBL-EBI EMBL-European Bioinformatics Institute Wellcome Trust Genome Campus, Hinxton Cambridge CB10 1SD United Kingdom Tel. +44 (0)1223 494 444, Fax +44 (0)1223 494 468 www.ebi.ac.uk EMBL Heidelberg Meyerhofstraße 1 69117 Heidelberg Germany Tel. +49 (0)6221 3870, Fax +49 (0)6221 387 8306 www.embl.org [email protected] EMBL Grenoble 6, rue Jules Horowitz, BP181 38042 Grenoble, Cedex 9 France Tel. +33 (0)476 20 7269, Fax +33 (0)476 20 2199 EMBL Hamburg c/o DESY Notkestraße 85 22603 Hamburg Germany Tel. +49 (0)4089 902 110, Fax +49 (0)4089 902 149 EMBL Monterotondo Adriano Buzzati-Traverso Campus Via Ramarini, 32 00015 Monterotondo (Rome) Italy Tel. +39 (0)6900 91402, Fax +39 (0)6900 91406 © 2012 EMBL-European Bioinformatics Institute All texts written by EBI-EMBL Group and Team Leaders. This publication was produced by the EBI’s Outreach and Training Programme. Contents Introduction Foreword 2 Major Achievements 2011 4 Services Rolf Apweiler and Ewan Birney: Protein and nucleotide data 10 Guy Cochrane: The European Nucleotide Archive 14 Paul Flicek: -
HENRY MARK JOHNSTON Date
CURRICULUM VITAE - HENRY MARK JOHNSTON Date: 31 March 2014 Date of Birth: December 20, 1951 Place of Birth: Stevens Point, Wisconsin Citizenship: USA Office Address: Department of Biochemistry and Molecular Genetics Home Address: University of Colorado School of Medicine 3352 Xenia St. Mail Stop 8101, P.O. Box 6511 Denver, CO 80238 Aurora, CO 80045 Phone 303-724-3201; Fax 303-724-3215 Education: 1974 Bachelor of Arts, University of Wisconsin, Madison. Field of Study: Molecular Biology Thesis: Genetics of Nitrogenase of K. pneumoniae; Mentor: Winston Brill 1980 Doctor of Philosophy, University of California, Berkeley. Field of Study: Mol. Biology Thesis: Regulation of the his Operon of S. typhimurium; Mentor: John Roth 1980-83 Postdoctoral Fellow, Department of Biochemistry, Stanford University School of Medicine Research: Molecular genetics of yeast GAL genes; Mentor: Ronald Davis Academic Positions: 2009 - Professor and Chair Department of Biochemistry and Molecular Genetics University of Colorado-Denver 1997 - 2008 Professor of Genetics Department of Genetics Washington University School of Medicine 1990 - 97 Associate Professor of Genetics Department of Genetics Washington University School of Medicine 1983 - 89 Assistant Professor of Genetics Department of Genetics Washington University School of Medicine Recognition: 2012 Elected to the American Academy of Arts and Sciences 2008 George W. Beadle Award, Genetics Society of America (see PMID: 18385105) 2006 Fellow, American Association for the Advancement of Science 2004 “B” Flight -
Rapid Mapping in Salmonella Typhimurium with Mud-P22 Prophages NICHOLAS R
JOURNAL OF BACTERIOLOGY, Mar. 1992, p. 1673-1681 Vol. 174, No. 5 0021-9193/92/051673-09$02.00/0 Copyright © 1992, American Society for Microbiology Rapid Mapping in Salmonella typhimurium with Mud-P22 Prophages NICHOLAS R. BENSON* AND BARRY S. GOLDMANt Department ofBiology, University of Utah, Salt Lake City, Utah Received 28 October 1991/Accepted 7 January 1992 A new method for mapping mutations in the Salmonella typhimurium chromosome is described and applied to the localization of novel regulatory mutations affecting expression of the nirB (nitrite reductase) gene. The mapping technique'is also illustrated by the mapping of mutations in genes affecting carbohydrate catabolism and biosynthetic pathways. The new mapping method involves use of the hybrid phage MudP and MudQ (together referred to as Mud-P22), originally constructed by Youderian et al. (Genetics 118:581-592, 1988). This report describes a set of Mud-P22 lysogens, each member of the set containing a different Mud-P22 insertion. The insertions are scattered along the entire Salmonella genome. These lysogens, when induced by mitomycin C, generate transducing lysates that are enriched (45- to 1,400-fold over the background, generalized transducing particle population) for transducing particles containing bacterial DNA that flanks one side of the insertion. We demonstrate that within the set of lysogens there can be found at least one Mud-P22 insertion that enriches for any particular region of the Salmonella chromosome and that, therefore, all regions of the chromosome are discretely enriched and represented by the collection as a whole. We describe a technique that allows the rapid and facile determination of which lysate contains enriched sequences for the repair of a mutant locus, thereby allowing the determination of the map position of the locus. -
RSE Fellows Ordered by Area of Expertise As at 11/10/2016
RSE Fellows ordered by Area of Expertise as at 11/10/2016 HRH Prince Charles The Prince of Wales KG KT GCB Hon FRSE HRH The Duke of Edinburgh KG KT OM, GBE Hon FRSE HRH The Princess Royal KG KT GCVO, HonFRSE A1 Biomedical and Cognitive Sciences 2014 Professor Judith Elizabeth Allen FRSE, FMedSci, Professor of Immunobiology, University of Manchester. 1998 Dr Ferenc Andras Antoni FRSE, Honorary Fellow, Centre for Integrative Physiology, University of Edinburgh. 1993 Sir John Peebles Arbuthnott MRIA, PPRSE, FMedSci, Former Principal and Vice-Chancellor, University of Strathclyde. Member, Food Standards Agency, Scotland; Chair, NHS Greater Glasgow and Clyde. 2010 Professor Andrew Howard Baker FRSE, FMedSci, BHF Professor of Translational Cardiovascular Sciences, University of Glasgow. 1986 Professor Joseph Cyril Barbenel FRSE, Former Professor, Department of Electronic and Electrical Engineering, University of Strathclyde. 2013 Professor Michael Peter Barrett FRSE, Professor of Biochemical Parasitology, University of Glasgow. 2005 Professor Dame Sue Black DBE, FRSE, Director, Centre for Anatomy and Human Identification, University of Dundee. ; Director, Centre for Anatomy and Human Identification, University of Dundee. 2007 Professor Nuala Ann Booth FRSE, Former Emeritus Professor of Molecular Haemostasis and Thrombosis, University of Aberdeen. 2001 Professor Peter Boyle CorrFRSE, FMedSci, Former Director, International Agency for Research on Cancer, Lyon. 1991 Professor Sir Alasdair Muir Breckenridge CBE KB FRSE, FMedSci, Emeritus Professor of Clinical Pharmacology, University of Liverpool. 2007 Professor Peter James Brophy FRSE, FMedSci, Professor of Anatomy, University of Edinburgh. Director, Centre for Neuroregeneration, University of Edinburgh. 2013 Professor Gordon Douglas Brown FRSE, FMedSci, Professor of Immunology, University of Aberdeen. 2012 Professor Verity Joy Brown FRSE, Provost of St Leonard's College, University of St Andrews. -
Experimental Surgery to Create Subgenomes of Bacillus Subtilis 168 (Recombination͞neomycin Resistance͞main Genome͞covalently Closed Circular Dna͞replication Origin)
Proc. Natl. Acad. Sci. USA Vol. 94, pp. 5378–5382, May 1997 Microbiology Experimental surgery to create subgenomes of Bacillus subtilis 168 (recombinationyneomycin resistanceymain genomeycovalently closed circular DNAyreplication origin) MITSUHIRO ITAYA* AND TERUO TANAKA† *Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida-shi, Tokyo 194, Japan; and †School of Marine Science and Technology, Tokai University, Shimizu, Shizuoka 424, Japan Communicated by John Roth, University of Utah, Salt Lake City, UT, February 25, 1997 (received for review March 1, 1996) ABSTRACT The 4,188-kb circular genome of Bacillus to term the autonomously replicating entity a subgenome of subtilis 168 was artificially dissected into two stable circular bacteria. chromosomes in vivo, one being the 3,878-kb main genome and the other the 310-kb subgenome that was recovered as co- MATERIALS AND METHODS valently closed circular DNA in CsCl-ethidium bromide ul- tracentrifugation. The minimal requirements to physically Bacterial Strains and Plasmids. B. subtilis 168 trpC2 was separate the 310-kb DNA segment out of the genome were two obtained from the Bacillus Genetic Stock Center (Columbus, interrepeat homologous sequences and an origin of DNA OH). All the BEST strains in this report are derived from this replication between them. The subgenome originated from the by integration of antibiotic resistance markers. The SfiI-NotI 1,255–1,551-kb region of the B. subtilis genome was essential physical map (14) of the B. subtilis 168 genome and the I-CeuI for the cell to survive because the subgenome was not lost from map, equivalent to the ribosomal RNA gene operon (rrn) map the cell. -
Science Without Borders 17–21 February, Washington, D.C
Preliminary Press Program Join Us in Washington, D.C. for Science and Fun Cover symposia on the implications of finding other worlds, the next steps in brain-computer interfaces, frontiers in chemistry, the next big solar storm, and more. Talk to leaders in science, technology, engineering, education, and policy-making. Gather story ideas for the year ahead. Mingle with colleagues at receptions and social events. It’s all available at the world’s largest interdisciplinary science forum. 2011 AAAS Annual Meeting Science Without Borders 17–21 February, Washington, D.C. CURRENT AS OF 1 NOVEMBER 2010 1 2011 AAAS Annual Meeting Science Without Borders Dear Colleagues, On behalf of the AAAS Board of Directors, it is my distinct honor to invite you to the 177th Meeting of the American Association for the Advancement of Science (AAAS). The Annual Meeting is one of the most widely recognized pan-science events, with hundreds of networking oppor- tunities and broad global media coverage. An exceptional array of speakers and attendees will gather at the Walter E. Washington Convention Center in Washington, D.C. You will have the opportunity to interact with scientists, engineers, educators, and policy-makers who will present the latest thinking and developments in their areas of expertise. The meeting’s theme — Science Without Borders — integrates interdisciplinary science, across both research and teaching, that utilizes diverse approaches as well as the diversity of its practitioners. The program will highlight science and teaching that cross conventional borders or break out from silos, especially in ground-breaking areas of research that highlight new and exciting developments in support of science, technology, and education. -
CSHL Undergraduate Research Program Participants 1959 - 2017
CSHL Undergraduate Research Program Participants 1959 - 2017 URP name University Advisor Research Project 1959 David Baltimore Swarthmore College A. Chovnick Physiological genetics of Drosophila and Neurospora Sandra Edwards Goucher College M. Demerec Bacterial genetics Frederick Gilman Michigan State University H. Gay Electron microscopy and cytogenetics Lucie Hicks Mount Holyoke College P.E. Hartman Bacterial genetics Nancy Metnick Rutgers University R.D. Hotchkiss Pneumococcus transformation Samuel Piel Harvard University B.P. Kaufmann Electron microscopy and cytogenetics Robert Reinhold Johns Hopkins University S.E. Luria Genetics of bacteriophage Philip Shambaugh Princeton University P. Margolin Bacterial genetics George Trager Cornell University H. Moser Tissue culture of normal and malignant mammalian cells Carole Weisbrot Brooklyn College G. Streisinger Genetics of bacteriophage viruses 1960 Philip Colbert Wesleyan University B.P. Kaufmann Effect of deoxyribonuclease in Drosophila Carol Dressel Michigan State University A. Chovnick Studies of a complex locus in Drosophila Kay L. Fields Radcliffe College P. Margolin Variation in transduction frequency in S. typhimurium Steven Jaffe Johns Hopkins University R. Franklin Chromosomal variation in normal and tumorous lines of mouse cells grown in vitro Charles Laird University of Oregon P. Margolin Mechanism of gene incorporation through transduction in S. typhimurium Marlene Martin Rutgers University A. Schalet Development of selective procedures for recombination studies in Drosophila Frances Messik Alfred University B.P. Kaufmann Effect of infrared irradiation on recombination in Drosophila June Rothman Swarthmore College M. Fox Cross-feeding between mutant and wild-type cells of E. coli 1961 Marietta Cassle Indiana University B.P. Kaufmann Study of chromosomes in human blood cells Gail Choder University of Pittsburgh E.