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The National Academies' Guidelines for Human Embryonic Stem Cell

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The National Academies' Guidelines for Human Embryonic Stem Cell THE NATIONAL ACADEMIES PRESS This PDF is available at http://nap.edu/11278 SHARE Guidelines for Human Embryonic Stem Cell Research DETAILS 178 pages | 6 x 9 | PAPERBACK ISBN 978-0-309-10856-0 | DOI 10.17226/11278 AUTHORS BUY THIS BOOK Committee on Guidelines for Human Embryonic Stem Cell Research, National Research Council FIND RELATED TITLES Visit the National Academies Press at NAP.edu and login or register to get: – Access to free PDF downloads of thousands of scientific reports – 10% off the price of print titles – Email or social media notifications of new titles related to your interests – Special offers and discounts Distribution, posting, or copying of this PDF is strictly prohibited without written permission of the National Academies Press. (Request Permission) Unless otherwise indicated, all materials in this PDF are copyrighted by the National Academy of Sciences. Copyright © National Academy of Sciences. All rights reserved. Guidelines for Human Embryonic Stem Cell Research GUIDELINES FOR HUMAN EMBRYONIC STEM CELL RESEARCH Committee on Guidelines for Human Embryonic Stem Cell Research Board on Life Sciences Division on Earth and Life studies Board on Health Sciences Policy Institute of Medicine Copyright National Academy of Sciences. All rights reserved. Guidelines for Human Embryonic Stem Cell Research THE NATIONAL ACADEMIES PRESS 500 Fifth Street, NW Washington, DC 20001 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. This material is based on work supported by the National Academies, the Ellison Medical Foundation, and the Greenwall Foundation. Library of Congress Cataloging-in-Publication Data Guidelines for human embryonic stem cell research / Board on Life Sciences, National Research Council, Board on Health Sciences Policy, Institute of Medicine. p. cm. Includes bibliographical references and index. ISBN 0-309-09653-7 (pbk.) — ISBN 0-309-55024-6 (pdf) 1. Embryonic stem cells— Research. 2. Human embryo—Research. I. National Research Council (U.S.). Board on Life Sciences. II. National Research Council (U.S.). Board on Health Sciences Policy. QH588.S83G85 2005 616′.02774—dc22 2005016338 Additional copies of this report are available from the National Academies Press, 500 Fifth Street, NW, Lockbox 285, Washington, DC 20055; (800) 624-6242 or (202) 334-3313 (in the Washington metropolitan area); Internet, http://www.nap.edu. Cover: A cluster of motor neurons and neural fibers derived from human embryonic stem cells in the lab of University of Wisconsin-Madison stem cell researcher and neurodevelop- mental biologist Su-Chun Zhang. The motor neurons are shown in red; neural fibers appear green and the blue specks indicate DNA in cell nuclei. These motor neurons were developed from one of James Thomson’s original human embryonic stem cell lines. Copyright for the photograph is held by the University of Wisconsin’s Board of Regents. Copyright 2005 by the National Academy of Sciences. All rights reserved. Printed in the United States of America Copyright National Academy of Sciences. All rights reserved. Guidelines for Human Embryonic Stem Cell Research The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Ralph J. Cicerone is president of the Na- tional Academy of Sciences. The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstand- ing engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also spon- sors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. Wm. A. Wulf is president of the National Academy of Engineering. The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Harvey V. Fineberg is president of the Institute of Medicine. The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy’s purposes of furthering knowledge and advising the federal govern- ment. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Acad- emy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Ralph J. Cicerone and Dr. Wm. A. Wulf are chair and vice chair, respectively, of the National Research Council. www.national-academies.org Copyright National Academy of Sciences. All rights reserved. Guidelines for Human Embryonic Stem Cell Research COMMITTEE ON GUIDELINES FOR HUMAN EMBRYONIC STEM CELL RESEARCH RICHARD O. HYNES (Co-Chair), Massachusetts Institute of Technology, Cambridge, Massachusetts JONATHAN D. MORENO (Co-Chair), University of Virginia, Charlottesville, Virginia ELIZABETH PRICE FOLEY, Florida International University, Miami, Florida NORMAN FOST, University of Wisconsin, Madison, Wisconsin H. ROBERT HORVITZ, Massachusetts Institute of Technology, Cambridge, Massachusetts MARCIA IMBRESCIA, Arthritis Foundation, Lynnfield, Massachusetts TERRY MAGNUSON, University of North Carolina, Chapel Hill, North Carolina CHERYL MWARIA, Hofstra University, Hempstead, New York JANET ROSSANT, Mount Sinai Hospital, Toronto, Ontario, Canada JANET D. ROWLEY, University of Chicago, Chicago, Illinois Board on Life Sciences Liaison to the Committee R. ALTA CHARO, University of Wisconsin, Madison, Wisconsin Staff FRANCES SHARPLES, Study Director ROBIN SCHOEN, Senior Program Officer MATTHEW D. MCDONOUGH, Program Assistant KATHI E. HANNA, Science Writer NORMAN GROSSBLATT, Senior Editor iv Copyright National Academy of Sciences. All rights reserved. Guidelines for Human Embryonic Stem Cell Research BOARD ON LIFE SCIENCES COREY S. GOODMAN (Chair), Renovis Inc., South San Francisco, California ANN M. ARVIN, Stanford University School of Medicine, Stanford, California JEFFREY L. BENNETZEN, University of Georgia, Athens, Georgia RUTH BERKELMAN, Emory University, Atlanta, Georgia R. ALTA CHARO, University of Wisconsin, Madison, Wisconsin DENNIS CHOI, Merck Research Laboratories, West Point, Pennsylvania JEFFREY L. DANGL, University of North Carolina, Chapel Hill, North Carolina PAUL R. EHRLICH, Stanford University, Palo Alto, California JAMES M. GENTILE, Research Corporation of America, Tucson, Arizona ED HARLOW, Harvard Medical School, Boston, Massachusetts DAVID HILLIS, University of Texas, Austin, Texas KENNETH F. KELLER, University of Minnesota, Minneapolis, Minnesota RANDALL MURCH, Virginia Polytechnic Institute and State University, Alexandria, Virginia GREGORY A. PETSKO, Brandeis University, Waltham, Massachusetts STUART L. PIMM, Duke University, Durham, North Carolina BARBARA A. SCHAAL, Washington University, St. Louis, Missouri JAMES TIEDJE, Michigan State University, East Lansing, Michigan KEITH YAMAMOTO, University of California, San Francisco, California Staff FRANCES E. SHARPLES, Director KERRY A. BRENNER, Senior Program Officer ROBIN SCHOEN, Senior Program Officer MARILEE K. SHELTON-DAVENPORT, Senior Program Officer ROBERT T. YUAN, Senior Program Officer ADAM P. FAGEN, Program Officer ANN REID, Program Officer EVONNE P. Y. TANG, Program Officer SETH STRONGIN, Senior Program Assistant MATTHEW D. MCDONOUGH, Program Assistant DENISE GROSSHANS, Financial Associate v Copyright National Academy of Sciences. All rights reserved. Guidelines for Human Embryonic Stem Cell Research BOARD ON HEALTH SCIENCES POLICY PHILIP PIZZO (Chair), Stanford University School of Medicine, Stanford, California LESLIE BENET, University of California, San Francisco, California DAVID BLUMENTHAL, Harvard Medical School & Massachusetts General Hospital, Boston, Massachusetts GAIL H. CASSELL, Eli Lilly and Company, Indianapolis, Indiana ELLEN WRIGHT CLAYTON, Vanderbilt University Law School, Nashville, Tennessee DAVID COX, Perlegen Sciences, Mountain View, California NANCY DUBLER, Montefiore Medical Center & The Albert Einstein College of Medicine, Bronx, New York ROBERT GIBBONS, University of Illinois at Chicago, Chicago, Illinois LYNN R. GOLDMAN, Johns Hopkins
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