The National Academies' Guidelines for Human Embryonic Stem Cell
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Will the Real Lawmakers Please Stand Up: Congressional Standing in Instances of Presidential Nonenforcement
PICKETT (DO NOT DELETE) 2/17/2016 12:23 PM Copyright 2016 by Bethany R. Pickett Printed in U.S.A. Vol. 110, No. 2 Notes and Comments WILL THE REAL LAWMAKERS PLEASE STAND UP: CONGRESSIONAL STANDING IN INSTANCES OF PRESIDENTIAL NONENFORCEMENT Bethany R. Pickett ABSTRACT—The Take Care Clause obligates the President to enforce the law. Yet increasingly, presidents use nonenforcement to unilaterally waive legislative provisions to serve their executive policy goals. In doing so, the President’s inaction takes the practical form of a congressional repeal—a task that is solely reserved for Congress under the Constitution. Presidential nonenforcement therefore usurps Congress’s unique responsibility in setting the national policy agenda. This Note addresses whether Congress has standing to sue in instances of presidential nonenforcement to realign and reaffirm Congress’s unique legislative role. In answering this question, this Note examines legislative standing precedent and argues that the Supreme Court’s reasoning supports a finding of congressional institutional standing. This Note further contends that it is normatively preferable for the judiciary to police the boundaries of each branch of government in instances of executive nonenforcement and apply the Constitution’s mandate that the President take care that the laws be faithfully executed. This maintains separation of powers and prevents one branch from unconstitutionally aggregating the power of another. AUTHOR—J.D. Candidate, Northwestern University School of Law, 2016; B.A., magna cum laude, The King’s College, 2012. Thank you to everyone on the Northwestern University Law Review who provided substantial feedback and improved this Note immeasurably. I am also overwhelmingly grateful to my family who has encouraged me in everything, and has been patient with me despite my work over countless holidays. -
The Bridge Between Science and the Future It Creates
Cell Stem Cell Resource Review Communicating Hope: the Bridge between Science and the Future It Creates The Stem Cell Hope: How Stem Cell Medicine Can Change Our Lives Alice Park New York, Hudson Street Press (2011) 336 pp., ISBN: 978-1-59463-078-1 Stem cells and hope. For those who place their futures in the perpetuation of biomedical research, these two constructs— stem cells and hope—have become nearly synonymous. For the scientific community, the potential for their work to be the basis of hope seems all too obvious. Science has long been the very vehicle by which society tackles its most pressing and perplexing challenges. It was Vannevar Bush, the first US presi- dential science advisor and the intellectual powerhouse behind the National Science Foundation, who championed the role that science would need to play in addressing broad social, the opponents’ court. Park notes that the Bush advisor Jay Lef- economic, and technological problems. However, it was also kowitz himself stated, ‘‘A lot of the conservative groups saw Vannevar Bush who stated, ‘‘A belief may be larger than this .a little bit as a surrogate for abortion.’’ Language that a fact,’’ and for stem cell research, this perceptive observation has framed the debate, such as ‘‘cloning,’’ ‘‘destruction,’’ made over 50 years ago has come to define the field. ‘‘fetus,’’ ‘‘abortion,’’ and ‘‘slippery slope,’’ is the very language Alice Park works to dispel some of the ‘‘belief-as-fact’’ pattern introduced and perpetuated by those who have no greater that has driven the social side of stem cell research in her book, interest in the field than to see its demise. -
Characterization of Embryonic Stem Cell-Differentiated Cells As Mesenchymal Stem Cells
The University of Southern Mississippi The Aquila Digital Community Honors Theses Honors College Fall 12-2015 Characterization of Embryonic Stem Cell-Differentiated Cells as Mesenchymal Stem Cells Rachael N. Kuehn University of Southern Mississippi Follow this and additional works at: https://aquila.usm.edu/honors_theses Part of the Cell Biology Commons Recommended Citation Kuehn, Rachael N., "Characterization of Embryonic Stem Cell-Differentiated Cells as Mesenchymal Stem Cells" (2015). Honors Theses. 349. https://aquila.usm.edu/honors_theses/349 This Honors College Thesis is brought to you for free and open access by the Honors College at The Aquila Digital Community. It has been accepted for inclusion in Honors Theses by an authorized administrator of The Aquila Digital Community. For more information, please contact [email protected]. The University of Southern Mississippi Characterization of Embryonic Stem Cell-Differentiated Cells as Mesenchymal Stem Cells by Rachael Nicole Kuehn A Thesis Submitted to the Honors College of The University of Southern Mississippi in Partial Fulfillment of the Requirements for the Degree of Bachelor of Science in the Department of Biological Sciences December 2015 ii Approved by ______________________________ Yanlin Guo, Ph.D., Thesis Adviser Professor of Biological Sciences ______________________________ Shiao Y. Wang, Ph.D., Chair Department of Biological Sciences ______________________________ Ellen Weinauer, Ph.D., Dean Honors College iii ABSTRACT Embryonic stem cells (ESCs), due to their ability to differentiate into different cell types while still maintaining a high proliferation capacity, have been considered as a potential cell source in regenerative medicine. However, current ESC differentiation methods are low yielding and create heterogeneous cell populations. -
Boosting the Cellular Potency of Embryonic Stem Cells by Spliceosome Targeting ✉ Wilfried A
Signal Transduction and Targeted Therapy www.nature.com/sigtrans RESEARCH HIGHLIGHT OPEN Boosting the cellular potency of embryonic stem cells by spliceosome targeting ✉ Wilfried A. Kues1 Signal Transduction and Targeted Therapy (2021) 6:324; https://doi.org/10.1038/s41392-021-00743-9 In recent work published in Cell, Shen et al.1 identified transfected ES cells with short interfering RNAs against different spliceosome inhibition in embryonic stem (ES) cells as a key spliceosome transcripts (the spliceosome consisted of 5 core and mechanism for the transition from pluri- to totipotency. Spliceo- several cofactor subunits, here 14 transcripts were targeted), some inhibition, achieved by RNA interference or the chemical respectively. Transient repression of 10 of the 14 splicing factors inhibitor pladienolide B, may gain widespread relevance to the resulted in ES cells, which maintained the typical colony culture of totipotent ES cells, in vitro differentiation of extra- morphology, however, pluripotent marker genes—Oct4 (Pou5f1), embryonal tissue and organoids, translation to the maintenance of Nanog, Sox2, Zfp42 and others—became down-regulated, at the pluripotent cells of other mammal species, including humans, and same time marker genes of totipotency—particularly Zscan4s and a better molecular understanding of cellular potency in stem cells MERVL—were up-regulated. Zscan4s (Zink finger and SCAN and cancer. domain containing 4) is a transcription factor and MERVL (murine The first successful isolation and maintenance of ES derived endogenous retrovirus L) an endogenous retrovirus with a usually fi 1234567890();,: from the inner cell mass (ICM) of murine blastocyst stages was restricted expression to 2-cell embryos. These results were veri ed described in 1981,2 and since then acted as game changer for by supplementing the culture medium with pladienolide B, a genetic studies in this mammalian model organism. -
Scientists Turn Skin Cells Into Motor Neurons in ALS Patients
Scientists Turn Skin Cells Into Motor Neurons in ALS Patients By Amanda Gardner HealthDay Reporter Thursday, July 31, 2008; 12:00 AM THURSDAY, July 31 (HealthDay News) -- Scientists have turned skin cells from patients with Lou Gehrig's disease into motor neurons that are genetically identical to the patients' own neurons. An unlimited number of these neurons can now be created and studied in the laboratory, a capability which should result in a better understanding of the disease and, one day, lead to new treatments or even the production of healthy cells that can replace the diseased ones. "The hope of some scientists is that they might be able to harness stem cells and program them to generate pluripotent stem cell lines [capable of differentiating into many different types of cells] which have the genes of patients," said Kevin Eggan, co-author of a paper appearing July 31 in the online version ofScience. "This would open up the possibility of producing a large supply of immune-matched cells to that patient that could be used in transplantation methodologies." "The other hope, and one that's much closer upon us . is if you could produce the cell types that become sick in that person, you might be able to use them in the laboratory to come to understand basic aspects of the disease and take the study of disease out of patients, where it's very difficult, and put it into the Petri dish," added Eggan, who is a principal faculty member at the Harvard Stem Cell Institute and spoke about the research at a teleconference Wednesday. -
Reopening Avenues for Attacking Amyotrophic Lateral Sclerosis 15 July 2016, by Hannah L
Reopening avenues for attacking amyotrophic lateral sclerosis 15 July 2016, by Hannah L. Robbins plays an important role in not only the nervous system, but also the blood and immune systems. "The point of our paper was to determine the function of this gene and what it normally helps to do in the body," said lead author Kevin Eggan, a professor in Harvard's Department of Stem Cell and Regenerative Biology (HSCRB) and an HSCI principal faculty member who has been studying ALS for more than a decade. According to Eggan, one way to better understand the gene is to catalog what is missing or goes awry when it is "knocked out," or inactivated. The scientists found that mice without a functional copy of the gene C9ORF72 had abnormally large spleens, livers, and lymph nodes, and got sick and In the murine spleen, lymphoid tissue (purple) is died. Mice with one working copy experienced responsible for launching an immune response to blood- similar but less severe changes. born antigens, while red pulp (pink) filters the blood. Mutations in the C9ORF72 gene, the most common mutation found in ALS patients, can inflame lymphoid "I realized immediately that the mouse knockout tissue and contribute to immune system dysfunction. had immune dysfunction," said Leonard Zon, a Credit: Dan Mordes, Eggan lab, Harvard Stem Cell professor in HSCRB, after seeing the preliminary Institute data at an informal presentation. The research team predicted that the gene mutation would affect neurons, but the finding that it Harvard Stem Cell Institute (HSCI) researchers at also inflamed other cells, namely those involved in Harvard University and the Broad Institute of autoimmunity, was "unexpected." With input from Harvard and MIT have found evidence that bone Zon and immunologist Luigi Notarangelo of Boston marrow transplantation may one day be beneficial Children's Hospital, the team decided to change to a subset of patients suffering from amyotrophic direction and further explore the gene's impact on lateral sclerosis (ALS), a fatal neurodegenerative the immune system. -
A Concise Review on the Classification and Nomenclature of Stem Cells Kök Hücrelerinin S›N›Fland›R›Lmas› Ve Isimlendirilmesine Iliflkin K›Sa Bir Derleme
Review 57 A concise review on the classification and nomenclature of stem cells Kök hücrelerinin s›n›fland›r›lmas› ve isimlendirilmesine iliflkin k›sa bir derleme Alp Can Ankara University Medical School, Department of Histology and Embryology, Ankara, Turkey Abstract Stem cell biology and regenerative medicine is a relatively young field. However, in recent years there has been a tremen- dous interest in stem cells possibly due to their therapeutic potential in disease states. As a classical definition, a stem cell is an undifferentiated cell that can produce daughter cells that can either remain a stem cell in a process called self-renew- al, or commit to a specific cell type via the initiation of a differentiation pathway leading to the production of mature progeny cells. Despite this acknowledged definition, the classification of stem cells has been a perplexing notion that may often raise misconception even among stem cell biologists. Therefore, the aim of this brief review is to give a conceptual approach to classifying the stem cells beginning from the early morula stage totipotent embryonic stem cells to the unipotent tissue-resident adult stem cells, also called tissue-specific stem cells. (Turk J Hematol 2008; 25: 57-9) Key words: Stem cells, embryonic stem cells, tissue-specific stem cells, classification, progeny. Özet Kök hücresi biyolojisi ve onar›msal t›p görece yeni alanlard›r. Buna karfl›n, son y›llarda çeflitli hastal›klarda tedavi amac›yla kullan›labilme potansiyelleri nedeniyle kök hücrelerine ola¤anüstü bir ilgi art›fl› vard›r. Klasik tan›m›yla kök hücresi, kendini yenileme ad› verilen mekanizmayla farkl›laflmadan kendini ço¤altan veya bir dizi farkl›laflma aflamas›ndan geçerek olgun hücrelere dönüflebilen hücrelerdir. -
Occupy Wall Street and the Tea Party Battle Over Energy Efficiency
Occupy Wall Street and the Tea Party Battle over Energy Efficiency Jeff Erickson, Navigant Consulting ABSTRACT Those involved in delivering or evaluating energy efficiency programs have had a reasonably comfortable relationship with environmental advocates over the years. In fact heightened environmental concerns helped spur the latest round of enthusiasm for energy efficiency among regulators and legislators. What about some of the other groups that are battling for the public’s attention lately – how might their efforts affect energy efficiency? If the Occupy Wall Street (OWS) movement grows how will it affect publicly-funded energy efficiency? Will utility-led energy efficiency programs be frowned upon by the OWS crowd? Will they want to see more states taking energy efficiency programs away from utilities and creating new institutions to run them (as, for example, is done in Wisconsin)? On the other side of the spectrum, will the Tea Party target energy efficiency regulations as evidence that the government has overstepped its constitutional purview? Will their push for deregulation lead to a pull back from regulations authorizing public-benefits charges to fund energy efficiency programs? This paper provides a framework for thinking about these questions and considering the potential ramifications if either of these movements grows in influence and targets energy efficiency. The paper will break the energy efficiency realm down into several parts representing key organizational or regulatory issues and consider the positions that the Tea Party and Occupy Wall Street members either have already expressed or are likely to express based on their foundational principles. Introduction Some individuals, families, businesses, and public sector entities take actions on their own accord, with their own money, to improve their energy efficiency. -
Ethical Challenges in Organoid Use
Article Ethical Challenges in Organoid Use Vasiliki Mollaki Hellenic National Bioethics Commission, PC 10674 Athens, Greece; [email protected] Abstract: Organoids hold great promises for numerous applications in biomedicine and biotech- nology. Despite its potential in science, organoid technology poses complex ethical challenges that may hinder any future benefits for patients and society. This study aims to analyze the multifaceted ethical issues raised by organoids and recommend measures that must be taken at various levels to ensure the ethical use and application of this technology. Organoid technology raises several serious ethics issues related to the source of stem cells for organoid creation, informed consent and privacy of cell donors, the moral and legal status of organoids, the potential acquisition of human “characteristics or qualities”, use of gene editing, creation of chimeras, organoid transplantation, commercialization and patentability, issues of equity in the resulting treatments, potential misuse and dual use issues and long-term storage in biobanks. Existing guidelines and regulatory frameworks that are applicable to organoids are also discussed. It is concluded that despite the serious ethical challenges posed by organoid use and biobanking, we have a moral obligation to support organoid research and ensure that we do not lose any of the potential benefits that organoids offer. In this direction, a four-step approach is recommended, which includes existing regulations and guidelines, special regulatory provisions that may be needed, public engagement and continuous monitoring of the rapid advancements in the field. This approach may help maximize the biomedical and social benefits of organoid technology and contribute to future governance models in organoid technology. -
Unique Unique
UNIQUE UNIQUE (ju^'ni^k) A. adj. 1. Of which there is only one; one and no other; single, sole, solitary. 2. a. That is or forms the only one of its kind; having no like or equal; standing alone in comparison with others, freq. by reason of superior excellence; unequalled, unparalleled, unrivalled. Oxford English Dictionary HSCI is a unique scientific enterprise THE HARVARD STEM CELL INSTITUTE is a unique scientific enterprise; nowhere else in the world are as many leading scientists gathered together to specifically focus on what today is one of the most important basic question in the life sciences: What is the property that allows stem cells not only to differentiate into any cell type in the body, but also makes it possible for them to reprogram other cells? And perhaps as significant, the Harvard Stem Cell Institute is a unique scientific enterprise because it is dedicated to bringing the answers to these questions to patients’ bedsides in the form of new treatments for conditions such as Parkinson’s disease, heart disease, cancer, blindness, and even dementias. scientific enterprise 4 } For a relatively brief interval ... researchers are Researchers believe that in as little as a decade it research solely on an individual lab basis, HSCI has hand, HSCI has established two major disease In 2005 HSCI provided its first dozen seed grants, intoxicated with a mix of the newly discovered may be possible to use embryonic stem cells to established collaborative platforms with other programs, the Cancer Stem Cell Program and The totaling $1.8 million, to launch innovative work by and the imaginable unknown. -
The Constitutional Implications of Human Cloning
Florida International University College of Law eCollections Faculty Publications Faculty Scholarship 2000 The Constitutional Implications of Human Cloning Elizabeth Price Foley Florida International University College of Law Follow this and additional works at: https://ecollections.law.fiu.edu/faculty_publications Part of the Constitutional Law Commons Recommended Citation Elizabeth Price Foley, The Constitutional Implications of Human Cloning , 42 Ariz. L. Rev. 647 (2000). Available at: https://ecollections.law.fiu.edu/faculty_publications/413 This Article is brought to you for free and open access by the Faculty Scholarship at eCollections. It has been accepted for inclusion in Faculty Publications by an authorized administrator of eCollections. For more information, please contact [email protected]. DATE DOWNLOADED: Mon Jul 13 16:11:09 2020 SOURCE: Content Downloaded from HeinOnline Citations: Bluebook 20th ed. Elizabeth Price Foley, The Constitutional Implications of Human Cloning, 42 Ariz. L. Rev. 647 (2000). ALWD 6th ed. Elizabeth Price Foley, The Constitutional Implications of Human Cloning, 42 Ariz. L. Rev. 647 (2000). APA 7th ed. Foley, E. (2000). The constitutional implications of human cloning. Arizona Law Review, 42(3), 647-730. Chicago 7th ed. Elizabeth Price Foley, "The Constitutional Implications of Human Cloning," Arizona Law Review 42, no. 3 (2000): 647-730 McGill Guide 9th ed. Elizabeth Price Foley, "The Constitutional Implications of Human Cloning" (2000) 42:3 Ariz L Rev 647. MLA 8th ed. Foley, Elizabeth Price. "The Constitutional Implications of Human Cloning." Arizona Law Review, vol. 42, no. 3, 2000, p. 647-730. HeinOnline. OSCOLA 4th ed. Elizabeth Price Foley, 'The Constitutional Implications of Human Cloning' (2000) 42 Ariz L Rev 647 Provided by: FIU College of Law -- Your use of this HeinOnline PDF indicates your acceptance of HeinOnline's Terms and Conditions of the license agreement available at https://heinonline.org/HOL/License -- The search text of this PDF is generated from uncorrected OCR text. -
Elizabeth Price Foley ______
Elizabeth Price Foley ______________________________________________________________________________ Professional Experience: Of Counsel, BakerHostetler, LLP, Washington, D.C., June 2014 to present. Of Counsel to Appellate and Major Motions section of national law firm, with emphasis on constitutional litigation and complex procedural issues. Professor of Law, Florida International University College of Law, Miami, Florida. Aug. 2002 to present. Tenured, founding faculty member of newly created public law school. Teach courses in constitutional law, health care law and civil procedure. Executive Director, Institute for Justice, Florida Chapter, Miami, Florida. March 2011 to Jan. 2013. Ran IJ’s newly created Florida chapter, including managing a six-figure budget, handling media and community outreach, and supervising two full-time staff attorneys, a paralegal, and several law-student interns. Also litigated constitutional claims in federal and state courts, focusing principally on areas such as economic liberty, the First Amendment, and property rights. The Institute for Justice is a non-profit, libertarian law firm based out of the Washington, D.C. area. Clinical Adjunct Professor, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida. August 2010 to August 2014. Team-taught course on Health Policy and Law to medical students. Provide annual lectures to medical students on various health law- related topics (e.g., health care fraud and abuse; medical malpractice; health care policymaking). Professor of Law, Michigan State University College of Law, East Lansing, Michigan. June 2000 to July 2002. Tenured professor. Taught courses in civil procedure, health care law, law and medicine, food and drug law, and evidence. Untenured Associate Professor from 1996-2000. Adjunct Professor, College of Human Medicine, Center for Ethics & Humanities, Michigan State University, Sept.