SLITRK6 Antibody Order 021-34695924

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M070825 SLITRK6 Antibody Order 021-34695924 [email protected] Support 400-6123-828 50ul [email protected] 100 uL Web www.abmart.cn Description: SLIT and NTRK-like family 6 (Slitrk6) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family. Slitrk6 expression has been observed in tissues such as tongue, lung, gastrointestinal tract, and pancreas. Like every other Slitrk protein except Slitrk1, overexpression of Slitrk6 inhibited neurite outgrowth in cultured neurons, suggesting that these proteins are involved in the control of neurite outgrowth. At least two isoforms of Slitrk6 are known to exisit. Uniprot: Q9H5Y7 Alternative Names： 4832410J21Rik; neuronal transmembrane protein Slitrk6; RP11-272M24.2; SLIT and NTRK- like family, member 6; SLIT and NTRK-like protein 6; slit and trk like gene 6; 4832410J21Rik; DFNMYP; SLITRK6; Sltk6; Specificity: SLITRK6 Antibody detects endogenous levels of total SLITRK6. Reactivity: Human, Mouse, Rat, Monkey Source: Mouse Mol.Wt.: 95kDa(Calculated); Storage Condition: Store at -20 °C. Stable for 12 months from date of receipt. 1 For in vitro research use only and not intended for use in humans or animals. Application: WB 1:1000-1:2000; IHC/IF 1:100-1:1000; FC 1:100-1:200 Immunohistochemical analysis of SLITRK6 staining in human human lung carcinoma formalin fixed paraffin embedded tissue section, using SLITRK6 antibody. 2 For in vitro research use only and not intended for use in humans or animals. .

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Old Data and Friends Improve with Age: Advancements with the Updated Tools of Genenetwork
bioRxiv preprint doi: https://doi.org/10.1101/2021.05.24.445383; this version posted May 25, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Old data and friends improve with age: Advancements with the updated tools of GeneNetwork Alisha Chunduri1, David G. Ashbrook2 1Department of Biotechnology, Chaitanya Bharathi Institute of Technology, Hyderabad 500075, India 2Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA Abstract Understanding gene-by-environment interactions is important across biology, particularly behaviour. Families of isogenic strains are excellently placed, as the same genome can be tested in multiple environments. The BXD’s recent expansion to 140 strains makes them the largest family of murine isogenic genomes, and therefore give great power to detect QTL. Indefinite reproducible genometypes can be leveraged; old data can be reanalysed with emerging tools to produce novel biological insights. To highlight the importance of reanalyses, we obtained drug- and behavioural-phenotypes from Philip et al. 2010, and reanalysed their data with new genotypes from sequencing, and new models (GEMMA and R/qtl2). We discover QTL on chromosomes 3, 5, 9, 11, and 14, not found in the original study. We narrowed down the candidate genes based on their ability to alter gene expression and/or protein function, using cis-eQTL analysis, and variants predicted to be deleterious. Co-expression analysis (‘gene friends’) and human PheWAS were used to further narrow candidates.
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