Prepared: 2/05/2011 University of California San Francisco
CURRICULUM VITAE
Name: Arthur Weiss, M.D., Ph.D.
Position: Ephraim P. Engleman Distinguished Professor of Rheumatology Professor of Medicine, Step VIII Professor of Microbiology and Immunology Chief, Division of Rheumatology Investigator, Howard Hughes Medical Institute
Address: Rheumatology/Immunology- S-1032 University of California, San Francisco, Box 0795 513 Parnassus Ave., San Francisco, CA 94143
Voice: (415) 476-8983 FAX: (415) 502-5081 Email: [email protected] http://www.ucsf.edu.rheumatology
EDUCATION:
1996-1973 Johns Hopkins University, Baltimore MD, B.A. Biology 1973-1978 University of Chicago, Pritzker School of Medicine Ph.D. Immunology 1973-1979 University of Chicago, Pritzker School of Medicine M.D. Medicine
LICENSES, CERTIFICATION:
1982 State of California G047287 1984 American Board of Internal Medicine 1986 American Board of Internal Medicine, Subspecialty Rheumatology
PRINCIPAL POSITIONS HELD:
1979-1980 Swiss Institute for Experimental Cancer Research, Lausanne Fellow Medicine 1980-1982 Dept of Medicine, University of California, San Francisco Intern/Resident Medicine 1982-1984 Howard Hughes Medical Institute, UCSF Associate Medicine University of California, San Francisco Fellow Rheumatology 1984-1985 Howard Hughes Medical Institute, University of California Instructor Medicine San Francisco Associate 1985-1988 University of California, San Francisco Assistant Clinical Professor of Medicine in Residence 1985-1988 University of California, San Francisco & Assist. Professor of Microbiology & Immunology in Residence 1985-1989 University of California, San Francisco, Assistant Medicine Investigator, Howard Hughes Medical Institute Investigator 1988-1989 University of California, San Francisco Assist. Professor Clinical of Microbiology and Immunology 1988-1989 University of California, San Francisco Assist. Professor Clinical
Arthur Weiss, M.D., Ph.D.
of Medicine 1987-present University of California, San Francisco Chief, Division Clinical of Rheumatology/ Clin. Immunology 1989-1991 University of California, San Francisco Associate Clinical Professor of Medicine 1989-1991 University of California, San Francisco Assoc. Professor Clinical of Microbiology and Immunology 1989-1993 University of California, San Francisco Associate Medicine Howard Hughes Medical Institute Investigator 1991-present University of California, San Francisco Ephraim P. Engleman Distinguished Professor of Rheumatology 1992-present University of California, San Francisco Professor Clinical of Medicine 1992-present University of California, San Francisco Professor of Medicine Microbiology and Immunology 1992-present Cell Biology Program, University of California Member Medicine 1992-present Biomedical Sciences Program, University of California, San Francisco Member Medicine 1993-present Howard Hughes Medical Institute, University Investigator of California, San Francisco 1998-2005 The Rosalind Russell Medical Research Center Associate Medicine for Arthritis, University of California, San Francisco Director 1999-present Cardiovascular Research Institute (CVRI), University of Member Medicine California, San Francisco, 2002-2006 Medical Scientist Training Program (MSTP) Director Medicine University of California, San Francisco 2007-2009 Institute for Molecular Medicine, University of Codirector California, San Francisco
HONORS AND AWARDS:
1973 Phi Beta Kappa, Department (Biology) and General Honors, Johns Hopkins University 1979 Sigma X, Department (Biology) and General Honors, Johns Hopkins University 1984 American Rheumatism Association Senior Rheumatology Scholar Award 1985 Gustavo Cudkowicz Memorial Lecture, FASEB 1985 American Federation of Clinical Research Trainee Award 1990 Young Investigator Award, Western Society for Clinical Investigation 1990 Henry Kunkel Young Investigator Award, American College of Rheumatology 1993 Junior Investigator Award, American Association of Immunologists 1997 Lee C. Howley Prize, Arthritis Foundation 1998 Forty-First Faculty Research Lecturer, University of California, San Francisco 1999 Eighth Heidelberger Distinguished Lecturer in Immunology, New York University School Medicine 2000 Marion E. Koshland Memorial Lecture, University of Chicago 2001 American Association of Immunologist-Huang Foundation Meritorious Career Award 2001 16th Ray and Robert Kroc Lecturer, Joslin Diabetes Clinic, Boston 2003 Washington University Immunology Program, Distinguished Visiting Professor 2003 Council, American Association of Immunologists 2003 Member, National Academy of Sciences 2003 Fellow, American Academy of Arts and Sciences
2 Arthur Weiss, M.D., Ph.D.
2004 Member, Institute of Medicine 2004 2nd Walter Bauer Lecturer, Massachusetts General Hospital 2004 Sue Kim Hansen Memorial Lecture, Boston University School of Medicine 2004 Fellow, American Academy of Microbiology 2004 American College of Rheumatology Distinguished Investigator Award 2004 Bridget Ogilvie Lecture, University of Dundee, Scotland 2005 Dan H. Campbell Memorial Lecture, Midwinter Conference of Immunology, Asilomar, CA 2005 Visiting Professor, Harvard Medical School Rheumatology Division 2005 Beirne B. Carter Lecture in Immunology, University of Virginia 2006 Keynote Speaker, American Association of Immunologists, Advanced Immunology Course 2009 Presidential Address, American Association of Immunologists 2009 Ishizaka Lecturer, La Jolla Institute of Allergy and Immunology 2009 46th Charles A. Stuart Memorial Lecture, Department of Microbiology and Immunology, Brown University 2010 Dorothy Baugh Harmon Endowed Lectureship, Oklahoma Medical Research Foundation
PROFESSIONAL ACTIVITIES:
CLINICAL
Chief, Division of Rheumatology, UCSF
INDUSTRY
Consultant, Upstate Biotechnology, Inc., Lake Placid, N.Y., 1994-2003 Scientific Advisory Board, Sugen, Inc., South San Francisco, CA, 1995-2003 Scientific Advisory Board, Compugen, Inc., Tel Aviv, Israel, 1998-2008 Scientific Advisory Board, Sunesis Pharmaceutics, Inc., Redwood City, CA, 2000-2006 Scientific Advisory Board Plexxikon, Inc., Berkeley, CA, 2001-present Health Care Advisory Board, Genencor International, Inc., Palo Alto, CA, 2002-2005 Scientific Advisory Board, Five Prime, Inc., South San Francisco, CA, 2004-present Scientific Advisory Board, Portola Pharmaceuticals, Inc., South San Francisco, 2006-present Consultant, Progenics Pharmaceutics, Inc., Tarrytown, NY., 2007 Consultant, Nodality, South San Francisco, CA., 2007 Scientific Advisory Board, Cellzome, Cambridge, UK, 2007-present Scientific Advisory Board, Lycera, Inc., Ann Arbor, MI, 2009-2010 Consultant, Bristol Myers-Squibb, Princeton, NJ, 2010
PROFESSIONAL ORGANIZATIONS:
Memberships
1984-present American Federation for Clinical Research 1981-present American Association of Immunologists 1986-present American Association for the Advancement of Science 1987-present Western Society for Clinical Investigation 1988-present American Society for Clinical Investigation 1988-present American College of Rheumatology 1992-present Western Association of Physicians 1994-present Association of American Physicians 1994-present American Society for Microbiology 1995-present American Society for Cell Biology
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Service to Professional Organizations 1986-1991 American Federation for Clinical Research Councilor Communications Committee and Public Policy Committee Awards Committee 1989 NIH Task Force on Allergy and Immunology Committee Member 1990 Western Region of the American College of Rheumatology Vice President 1991 Western Region of the American College of Rheumatology President 1993 American Association of Immunologists Nominating Committee 1993-1996 American Association of Immunologists Nominating Committee 1996-1999 American Association of Immunologists Research Granting Agencies Liaison Committee 1997 American Association of Immunologists Nominating Committee 1998-1999 American Association of Immunologists Public Affairs Committee 2003-2010 American Association of Immunologists Council Member 2007-2008 American Association of Immunologists Vice President 2008-2009 American Association of Immunologists President 2007-2010 National Academy of Sciences (elected position) Class Membership Committee
SERVICE TO PROFESSIONAL PUBLICATIONS:
1986-1991 Associate Editor, Journal of Immunology 1990-1992 Editorial Board, The New Biologist 1991-1996 Editorial Committee, The Journal of Clinical Investigation 1992-2006 Advisory Editor, The Journal of Experimental Medicine 1994-present Editorial Board, Immunity 1994-2002 Board of Reviewing Editors, Science 1996-1999 Editorial Board, Proceedings of the Association of American Physicians 1996-2008 Transmitting Editor, International Immunology 1999-2009 Editorial Board, Cell 2002-present Editorial Board, Immunological Reviews 2008-present Editorial Board, Proceedings of the National Academy of Sciences, USA
Ad-Hoc Editor (average of 2 papers per month from one of the following) Nature Science Journal of Biological Chemistry Cell Regulation Molecular and Cellular Biology European Journal of Immunology Journal of Cell Biology Journal of Immunology Journal of Experimental Medicine Journal of Clinical Investigation Blood European Molecular Biology Organization Journal
INVITED PRESENTATIONS (2003-present):
INTERNATIONAL
British Society for Immunology Congress, Harrogate, England, 2003, Invited Speaker 12th Symposium on Signal Transmission and Processing in the Immune System, Sopron,
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Hungary, 2003, Invited Speaker Shanghai Genomics, Inc., Invited Seminar, Shanghai, China, 2004, Invited Seminar Speaker University of Dundee, Bridget Ogilvie Lecture, Dundee Scotland, 2004, Lecturer International Congress of Immunology, Invited Speaker, 2004, Montreal, Canada International Congress of Second Messengers and Protein Phosphorylation, Montreal, 2004, Invited Speaker EMBO Workshop on Lymphocyte Activation, Siena, Italy, 2004, Invited Speaker Riken-Japanese Society of Immunology, International Symposium on Immunology, Yokohama, Japan, 2005, Invited Speaker and International Advisory Board 3rd Annual Cell Signaling Symposium, Dundee, Scotland, 2006, Invited Speaker Riken Institute Summer School in Immunology, Yokohama, Japan, 2006, Invited Speaker EMBO Workshop on “Antigen Receptor Signaling”, Siena, 2007, Invited Speaker Schering Meeting on “Kinases in the Immune System”, Berlin, 2007, Opening Speaker International Congress of Immunology, Symposium on Lymphocyte Activation, Rio de Jaenero, 2007, Invited Speaker Signal Transduction in Normal and Cancer Cells, Banf, Canada, 2008, Invited Speaker Riken-JSI International Symposium on Immunology, Yokohama, Japan, 2008, Invited Speaker FEBS/ESF 16th Meeting on Protein Kinases, Oslo, Norway, 2008, Invited Speaker 2nd International Symposium on Regulators of Adaptive Immunity, Erlangen, Germany, 2008, Invited Speaker EMBO Workshop on The Initiation of Antigen Receptor Signaling, Madrid, Spain, 2008, Meeting Co-Organizer Symposium Honoring Peter Beverley, Oxford University, UK, 2009, Invited Speaker Meeting of the European Network of Immunology Institutes, Sardinia, Italy, 2009, Invited Speaker Academy of Sciences, Prague, Czech Republic, 2009, Invited Seminar EMBO Conference on “Signaling in the Immune System”, Siena, Italy, 2009, Invited Speaker German Signal Transduction Society, Annual Meeting, Weimar, Germany, 2009, Keynote Speaker EMBO Meeting on Cellular Signaling and Molecular Medicine, Dubrovnik, Croatia, 2010, Meeting Co-Organizer and Speaker International Congress of Immunology, Kobe, Japan, 2010, Invited Speaker FEBS Workshop on “Spatiotemporal Dynamics of Cell Signaling”, Oslo, Norway, 2010, Invited Speaker T cell workshop, Norwegian Society of Immunology, Oslo, Norway, 2010, Invited Speaker 5th Garvan Signaling Symposium, Garvan Institute, Sydney, Australia, 2010, Invited Speaker Seminar, University of Toronto, Department of Immunology, Toronto, Canada, 2011, Invited Seminar
NATIONAL
Immunology Forum and Cancer Center, UCLA, CA, 2003, Invited Seminar Dept. of Cellular and Structural Biology, UT San Antonio, TX, 2003, Invited Seminar Director's Seminar, NIH, Bethesda Immunology Program, Washington Univ., St. Louis, MO, 2003, Distinguished Visiting Professor Seminar Immunology Program, "Perspectives in Immunology", Scripps Research Inst., La Jolla, CA, 2003, Invited Speaker "Rising Star Symposium, 75th Anniversary of the Pritzker School of Medicine, University of Chicago, Chicago, IL, 2003, Invited Speaker FASEB Summer Conference on "Signaling in the Immune System", Snowmass, CO, 2003, Invited Speaker Cancer and Immunity Meeting, Baylor College of Medicine, Houston, TX, 2003, Invited Speaker Keystone Meeting on “Lymphocyte Activation”, Steamboat Springs, CO, 2004, Keynote Speaker MSTP Lecture Series, UC Irvine, Irvine, CA, Invited Seminar, 2004 Immunology Program, Johns Hopkins Medical School, Baltimore, MD, 2004, Invited Seminar Walter Bauer Visiting Professor, Massachusetts General Hospital, Boston, MA, 2004, Invited Seminar Distinguished Scientist Seminar, University of Buffalo School of Medicine, Buffalo, NY, 2004, Invited Seminar Abbott Scholar Program in Rheumatology, Miami, FL, 2004, Invited Seminar La Jolla Institute for Allergy and Immunology, La Jolla, 2004, Invited Seminar
5 Arthur Weiss, M.D., Ph.D.
Dept. of Biology, UCSD, San Diego, CA, Invited Seminar, 2004 Bristol Myers-Squibb, Princeton, NJ, 2004, Invited Seminar Sue Kim Hansen Lecture, Boston University School of Medicine, Boston, MA, 2004, Invited Seminar Minisymposium on New Therapies, American College of Rheumatology, San Antonio, TX, 2004, Invited Speaker MSTP student speaker, Case Western Reserve Medical School, Cleveland, OH, 2004, Invited Seminar Dan H. Campbell Memorial Lecture, Midwinter Conference of Immunology, Asilomar, CA, 2005, Invited Speaker Harvard School of Medicine, Immunology Program, Boston, MA, 2005, Invited Seminar Rheumatology Grand Rounds, Brigham and Women’s Hospital, Boston, MA, 2005, Invited Seminar Vollum Institute, Oregon Health Sciences University, Portland, OR, 2005, Invited Seminar Keystone Meeting on “Lymphocyte Activation,” Steamboat Springs, CO, 2006, Invited Speaker National Jewish Medical and Research Center, Denver, CO, 2006, Distinguished Speaker Seminar Series Duke University, Immunology Program, Durham, NC, 2006, Invited Seminar Lineberger Cancer Center, University of North Carolina, Chapel Hill, NC, 2006, Invited Seminar 3rd Annual FOCIS Trainee Satellite Symposium, San Francisco, CA, 2006, Keynote Speaker American Association of Immunologists, Advanced Course in Immunology, Stanford U. campus, 2006, Keynote Speaker Immunology Department, University of Pittsburgh, PA, 2006, Invited Seminar U. of Washington, Immunology Program, Seattle, WA, 2007, Invited Seminar Harvard Medical School, Immunology Program, Boston, MA, 2007, Invited Seminar U. of Pennsylvania, Immunology Program, Philadelphia, PA, 2007, Student Hosted Seminar Speaker FASEB Summer Conference on “Signaling in the Immune System, Snowmass, CO, 2007, Invited Speaker FASEB Summer Conference on “Kinases and Protein Phosphorylation”, Indian Well, CA, 2007, Invited Speaker Gladstone Institute for Virology and Immunology, San Francisco, CA, 2007, Invited Seminar USAMRIID Seminar, Frederick, MD, 2007, Invited Seminar Yale University School of Medicine, Immunology Department, 2007, Invited Seminar Keystone Meeting on “Lymphocyte Activation”, Snowbird, Utah, 2008, Invited Speaker Immunology Department, UCLA, 2008, Invited Seminar New York University, Department of Immunology, 2008, Invited Speaker American Association of Immunologists, San Diego, CA, 2008, Invited Speaker FASEB Summer Conference on “Immunoreceptors”, New Haven, CT, 2008, Invited Speaker American College of Rheumatology, San Francisco, 2008, Invited Speaker Stanford University Immunology Colloquium, Palo Alto, CA, 2009, Invited Seminar Scripps Research Institute, Immunology Program, La Jolla, CA, 2009, Invited Seminar University of Chicago Immunology Program, Chicago, IL, 2009, Invited Seminar University of Iowa, Immunology Graduate Program, Iowa City, IO, 2009, Student Invited Speaker Post-Kyoto Prize Symposium honoring Tony Pawson, La Jolla, CA, 2009, Invited Speaker Presidential Address, American Association of Immunologists, Seattle, WA, 2009, Invited Address FASEB Summer Conference on “Lymphocyte Activation”, Snowmass, CO, 2009, Invited Speaker Duke University, Department of Pharmacology and Cancer Biology, Durham, NC, 2009, Seminar Speaker La Jolla Institute of Allergy and Immunology, La Jolla, CA, 2009, Ishizaka Lecture Brown University, Providence, RI., 2009, 46th Stuart Memorial Lecture Cellgene, Inc., La Jolla, CA, 2010, Seminar Speaker Keystone Meeting on Lymphocyte Activation and Gene Expression, Breckinridge, CO, 2010, Invited Speaker and Session Chair Cold Spring Harbor Meeting on Lymphocyte Signaling and Gene Expression, Cold Spring Harbor, NY, Invited Speaker and Session Chair Oklahoma Medical Research Foundation, Oklahoma City, OK, 2010, Dorothy Baugh Harmon Endowed Lectureship Bristol-Myers Squibb, Inc., Princeton, NJ, 2010, Invited Seminar Speaker Department of Chemistry, UC Berkeley, 2010, Invited Seminar
REGIONAL AND OTHER INVITED PRESENTATIONS
2002 Immunology Program, UC Berkeley, Invited Seminar 2003 Invited Seminar, Immunology Program, Stanford University
6 Arthur Weiss, M.D., Ph.D.
2003 Invited Speaker, BMS Faculty Luncheon, UCSF 2003 Medical Grand Rounds, UCSF 2003 Medical Grand Rounds, SF VAMC 2004 Biomedical Sciences Program, UCSF, Invited Seminar 2006 Invited Seminar, Department of Microbiology and Molecular Genetics, UC Irvine 2007 Invited Speaker, Immunology Program, UCSF 2007 Invited Speaker, BMS Faculty Luncheon, UCSF 2008 Medical Grand Rounds, UCSF
CME COURSES ATTENDED
2005 FASEB Summer Research Conferences Protein Kinases and Protein Phosphorylation 2006 Postgraduate Institute of Medicine End of Life Cure and Pain 2007 The 41st Annual Knowles Lecture Rheumatoid Arthritis Treatment 2007 and 2017 2007 Annals of Internal Medicine In the Clinic – Osteoarthritis 2008 The Role of Selected Immunomodulators in Rheumatoid Arthritis: A Visual of Therapeutic Interventions 2008 Keystone Symposium Lymphocyte Activation and Signaling 2008 2nd International GK Symposium Regulators of Adaptive Immunity 2008 FASEB “Immunoreceptors” 2008 American College of Rheumatology Scientific Activity 2009 Medscape The Role of Selected Immunomodulators in Rheumatoid Arthritis: A Visual Overview of Therapeutic Interventions 2010 Keystone Symposium on Lymphocyte Activation and Signaling 2010 International Congress of Immunology
GOVERNMENT AND OTHER PROFESSIONAL SERVICE:
1989 NIH Task Force on Allergy and Immunology 1998 Task Force on Immunology, National Institute of Allergy and Infectious Diseases (NIAID) 1998-2002 Member, Allergy and Immunology Study Section 2000-2002 Chair, Allergy and Immunology Study Section, National Institutes of Health
UNIVERSITY AND PUBLIC SERVICE
UNIVERSITY SERVICE:
SYSTEMWIDE
1994-1998 Advisory Committee for the Cancer Research Laboratory, UC Berkeley
SCHOOL OF MEDICINE
1986-present Medical Scientist Training Program (MSTP) Council and Director (2002-2006) 1989-present Molecular Medicine Training Program Executive Committee 1989-1992 Program in Biological Sciences Executive Council 1996-2006 Program in Biological Sciences Executive Council 1986-1988 Immunology Training Program Steering Committee 1996-2001 Brook Byers Award for Basic Science Research Award Committee 1998-2001 Basic Sciences Research Resources Oversight Committee 1998-2005 Associate Director, Rosalind Russell Medical Research Center for Arthritis 1999-present Executive Committee, UCSF Sandler Center for Asthma 1998-2002 Immunology Training Program Steering Committee 2002-present Parnassus Heights Leadership Council 2002-2006 Biomedical Sciences Executive Committee 2005-present Advisory Board for the CHRCDA, UCSF Pediatric Hematology 2007-2009 Co-Director, Institute for Molecular Medicine
7 Arthur Weiss, M.D., Ph.D.
DEPARTMENT SERVICE
1998-2003 Department of Medicine Promotions Committee 2009 Department of Medicine Strategic Planning, Research Subcommitee
Search Committees 2000-2002 Sandler Distinguished Professor in the Immunology of Asthma Research 2002-2003 Cardiovascular Research Institute, Junior faculty position 2002-2003 Rheumatology Division, Junior faculty position 2003-2004 Chief, Division of Infectious Disease 2006-2007 Chair, Department of Medicine 2007 Director, Parnassus Microscopy Core 2007 Chief, Division of Oncology 2008-2009 Co-Chair, Dean School of Medicine 2009 Chair, Search Committee, Ken Fye Chair in Rheumatology 2009 Chair, Search Committee, Rheumatology Clinical Series Faculty 2010 Chair, Subcommittee, Allergist and Immunology, Pulmonary Division
PUBLIC SERVICE:
1988-1991 Member, Fellowship Screening Committee for American Cancer Society, California Division 1992-2000 Member, External Advisory Committee, University of Chicago Cancer Research Center 1997-present Host, Laboratory Tour, Arthritis Foundation 1999-present Chair, Scientific Advisory Board, Sandler Program for Asthma Research; renamed American Asthma Foundation 2005-present Advisory Council, RIKEN Research Center for Allergy & Immunology, Yokohama, Japan 2006 Member, Overseers’ Committee to Visit the Division of Medical Sciences, Harvard Medical School 2007-present Temporary Nominating Group for Clinical Science, National Academy of Sciences 2010-present Board of Directors, Immune Tolerance Institute
TEACHING AND MENTORING:
FORMAL SCHEDULED CLASSES FOR UCSF STUDENTS
Qtr Academic Yr Course No. & Title Teaching Contribution Units ClassSize
F 1987-present Micro 204: Molecular and Cellular Lecturer 6 10-25 Immunology
F 2004-present 13 Block, Core Curr. Lecturer 1 140
13 Block Core, Curr. Discussion 3 20
S 2007 Micro 209: Molecular and Cellular Course Director 50 15 Immunology: Thymic Development
8 Arthur Weiss, M.D., Ph.D.
PREDOCTORAL STUDENTS SUPERVISED OR MENTORED
Dates Summer Students/Name School 1998 Rachel Kowal Haverford College 2000 Jennifer Su Yale University 2003-2004 Shyam Gadwal University of Maryland 2004 Mandy Young MIT 2005 David Caretto UCSF
PREDOCTORAL STUDENS SUPERVISED OR MENTORED:
Dates Name Fellow Faculty Role Current Position
1986-1988 Mark A. Goldsmith Immunol., MSTP PhD Advisor CEO, Constellation, Inc., Cambridge, MA 1989-1993 Bryan A. Irving Physiology PhD Advisor Scientist, Genentech, Inc. 1990-1994 Dev Desai Immunol., MSTPPhD PhD Advisor Assoc. Prof., Transpl. Surgery, UTSW, Dallas SOM 1994-1996 Monica Sieh Moore Immunology PhD Advisor Associate Investigator, Gallo Inst. 1991-1997 Jun Wu Immunology PhD Advisor CSO, Shanghai Genomics, China 1994-1999 David H. Chu Immunol., MSTP PhD Advisor Dermatologist, Private Practice 1994-2000 Ravi Majeti BMS, MSTP PhD Advisor Assistant Prof, Hematology Division, Stanford, SOM 1994-2001 Jen Liou Biomed Sciences PhD Advisor Assistant Professor, Physiology Dep., UTSW Dallas SOM 1992-2001 Tomasz Sosinowski Biomed Sciences PhD Advisor Postdoc, National Jewish Medical an Research Center 1994-2002 Zheng Xu Cell Biology PhD Advisor Postdoc, UCSD, SOM 1998-2002 Gregory M. Ku BMS, MSTP PhD Advisor Endocrine Fellow, UCSF, SOM 1999-2004 Joseph Lin Biomed Sciences PhD Advisor Assistant Prof, Dept. of Biology, Sonoma State U. 1999-2005 Margaret Myers Biomed Sciences PhD Advisor Postdoc, UCLA, SOM 2001-2007 Emil Palacios Biomed Sciences PhD Advisor Scientist, Cellera, Inc., Alameda, CA 2001-2007 Vikas Gupta BMS, MSTP PhD Advisor Medical Resident, Emery U., AL
2003-2007 Susan Levin Biomed Sciences PhD Advisor Assist. Prof, Tufts University 2008-present Ying Xim Tan Biomed Sciences PhD Advisor 2010-present Kasia Skrzypczynska Biomed Sciences PhD Advisor
POSTDOCTORAL FELLOWS AND RESIDENTS DIRECTLY SUPERVISED OR MENTORED:
Dates Name Fellow Faculty Role Current Position
1985-1987 Timothy Laing, M.D. Postdoc Res supervisor Professor, Vice Chair, Department of Medi Ann Arbor, MI 1985-1987 Bernhard Manger, M.D. Postdoc Res supervisor Professor, Department of Medicine, Univer of Erlangen, West Germany 1985-1989 Linda K. Bockenstedt, M.D. Postdoc Res supervisor Professor, Department of Medicine, Yale University, New Haven, CT 1987-1991 Gary Koretzky, M.D., Ph.D Postdoc Res supervisor Professor and Vice Chair of Research, Department of Medicine, University of Pennsylvania School of Medicine, Philadel PA 1988-1991 Joel Picus, M.D. Postdoc Res supervisor Professor of Medicine, Department of Medicine, Washington University, St. Loui MO 1988-1992 Martha Graber, M.D. Postdoc Res supervisor Associate Professor, Division of Nephrolog Department of Medicine, Dartmouth Medic School, Hanover, NH
9 Arthur Weiss, M.D., Ph.D.
1988-1993 James Fraser, Ph.D Postdoc Res supervisor Senior Scientist, Pfizer, Inc., New Jersey 1988-1993 Lee Tan, Ph.D. Postdoc Res supervisor Biotechnology Specialist, Genentech, Inc., South San Francisco, CA 1989-1993 Andrew Chan, M.D., Ph.D. Postdoc Res supervisor Vice President, Senior Director of Immunology, Genentech, Inc., So. San Francisco, CA 1989-1994 Makio Iwashima, Ph.D. Postdoc Res supervisor Associate Professor, Department of Microbiology and Immunology, Loyola Sc of Medicine, Chicago, IL 1989-1994 David Straus, Ph.D. Postdoc Res supervisor Associate Professor, Department of Microbiology Medical College of Virginia, Charlottesvill VA 1990-1994 Peter Stein, M.D. Postdoc Res supervisor Rheumatology Private Practice, Santa Rosa CA 1993-1996 Louise Howe, Ph.D. Postdoc Res supervisor Associate Research Professor, Weill Medic College of Cornell University, New York, 1995-1996 Charlene Liao, Ph,D. Postdoc Res supervisor Technology Transfer Specialist, Genentech Inc., So. San Francisco, CA 1994-1997 Alicia Fry, M.D. Postdoc Res supervisor Clinical Epidemiologist, Centers for Diseas Control, Atlanta, GA 1994-1997 Nicolai Van Oers, Ph.D Postdoc Res supervisor Associate Professor, Department of Microbiology, University of Texas Southwestern Medical Crenter, Dallas, TX 1994-1997 Dapeng Qian, M.D., Ph.D. Postdoc Res supervisor Director, Drug Discovery, Progenics, Inc. Tarrytown, NY 1994-1998 Qihong Zhao, PhD. Postdoc Res supervisor Senior Scientist, Bristol Myers Squibb, Inc Princeton, NJ 1995-1999 Deborah Yablonski, PhD. Postdoc Res supervisor Associate Professor, Department of Pharmacology, Technion-Israel Institute of Technology, Haifa, Israel 1995-1999 Timothy S. Finco, Ph.D. Postdoc Res supervisor Associate Professor, Department of Biolog Agnes Scott College, Decatur, GA 1994-2000 Virginia S. Shapiro, Ph.D Postdoc Res supervisor Associate Professor, Department of Immunology, Mayo Clinic Medical School Rochester, MN 1999-2000 Tiffani A. Cook, Ph.D. Postdoc Res supervisor Senior Scientist, Integral Molecular, Inc., Philadelphia, PA 1998-2000 Jeanne Baker, Ph.D. Postdoc Res supervisor Senior Scientist, Elan Pharmaceuticals, So. Francisco, CA 1996-2000 Lawrence P. Kane, Ph.D. Postdoc Res supervisor Associate Professor, Department of Immunology, University of Pittsburgh, Pittsburgh, PA 1997-2001 Kristen Lynch, Ph.D Postdoc Res supervisor Associate Professor, Department of Biophy Univ. of Pennsylvania, Philadelphia, PA 1997-2001 Jeffrey Critchfield, M.D. Postdoc Res supervisor Associate Clinical Professor Department of Medicine Chief of Staff, San Francisco General Hos University, University of California, San Francisco 1997-2001 Michelle R. Kuhne, Ph.,D. Postdoc Res supervisor Research Scientist, Medarex, Inc., Mountai View, CA 1999-2003 Michael Tomlinson, Ph.D Postdoc Res supervisor Instructor, Univ. of Birmingham, England 2003-2004 Zheng Xu, Ph.D. Postdoc Res supervisor Staff Research Scientist, UCSD, San Diego CA 1999-2004 Jeroen Roose, Ph.D. Postdoc Res supervisor Assistant Professor, Dept. of Anatomy, UC 2000-2002 Michelle Hermiston, M.D., Ph.D. Postdoc Res supervisor Assistant Professor, Hematology Div., Dept. of Pediatrics, UCSF
2001-2003 Leonard Dragone, M.D., Ph.D Postdoc Res supervisor Assistant Professor, Dept. of Pediatrics, Na Jewish Medical and Research, Denver CO 2001-2003 Ajay Nirula, M.D., Ph.D Postdoc Res supervisor Senior Scientist, Biogen-Idec, San Diego, C 2003-2006 Tomasz Brdicka, PhD Postdoc Res supervisor Assistant Professor, U. Prague, Czech Repu
2005-2009 Soren Beinke, Ph.D. Postdoc Res supervisor Scientist, Glaxo-Smith Kline, Cambridge, U 2007-2009 Ethan Corcoran, M.D., PhD Postdoc Res supervisor Pulmonary Physician, Kaiser Health Ctr, Portlandf, OR 2007-2010 Jamie Schoenborn, Ph.D Postdoc Res supervisor Postdoctoral Fellow, Fred Hutchinson Can Inst., Seattle, WA
10 Arthur Weiss, M.D., Ph.D.
2003-present Hyewon Phee, Ph.D. Postdoc Res supervisor 2003-present Jing Zhu, Ph.D. Postdoc Res supervisor 2004-present Lyn Hsu, Ph.D Postdoc Res supervisor 2005-present Andre Limnander, Ph.D. Postdoc Res supervisor 2006-present Julie Zikherman, M.D. Postdoc Res supervisor 2006-present Tamiko Katsumoto, M.D. Postdoc Res supervisor 2007-present Byron Au-Yeung, Ph.D Postdoc Res supervisor 2007-present Tanya Freedman, Ph.D. Postdoc Res supervisor 2008-present Hanna Sjolin-Goodfellow, Ph.D. Postdoc Res supervisor 2009-present Haopeng Wang, Ph.D. Postdoc Res supervisor
11 Arthur Weiss, M.D., Ph.D.
PEER REVIEWED PUBLICATIONS
1. Edidin, M. and Weiss, A.: Antigen cap formation in cultured fibroblasts: a reflection of membrane fluidity and of cell motility. Proc. Natl. Acad. Sci. USA 69:2456-2459, 1972.
2. Weiss, A.: Suppression of adult rat lymphoid proliferative responses by homologous neonatal serum. J. Immunol. 118:1121-1123, 1977.
3. Weiss, A. and Fitch, F.W.: Macrophages suppress CTL generation in rat mixed leukocyte cultures. J. Immunol. 119:510-516, 1977.
4. Weiss, A. and Fitch, F.W.: Suppression of the plaque-forming cell response by macrophages present in the normal rat spleen. J. Immunol. 120:357-359, 1978.
5. Weiss, A., Fitch, F.W. and Stuart, F.P.: Immunologic memory is regulated in the enhanced rat renal allograft recipient. Nature 273:662-664, 1978.
6. Weiss, A., Stuart, F.P. and Fitch, F.W.: Immune reactivity of cells from long-term rat renal allograft survivors. Transplant. 26:346-352, 1978.
7. Weiss, A., Brunner, K.T., MacDonald, H.R. and Cerottini, J.-C.: Antigenic specificity of the cytolytic T lymphocyte (CTL) response to murine sarcoma virus-induced tumors. III. Characterization of CTL clones specific for Moloney leukemia virus associated cell surface antigens. J. Exp. Med. 152:1210-1225, 1980.
8. Weiss, A., MacDonald, H.R., Cerottini, J.-C. and Brunner, K.T.: Inhibition of cytolytic T lymphocyte clones reactive with Moloney leukemia virus associated antigens by monoclonal antibodies: A direct approach to the study of H-2 restriction. J. Immunol. 126:482-485, 1981.
9. Weiss, A., Wiskocil, R. and Stobo, J.D.: The role of T3 surface molecules in the activation of human T cells: A two stimulus requirement for IL-2 production reflects events occurring at a pre-translational level. J. Immunol. 133:123-128, 1984.
10. Weiss, A., Imboden, J., Shoback, D. and Stobo, J.: Role of T3 surface molecules in human T cell activation: T3 dependent activation results in a rise in cytoplasmic free calcium. Proc. Natl. Acad. Sci. USA 81:4169-4173, 1984.
11. Weiss, A., Imboden, J., Wiskocil, R. and Stobo, J.: The role of T3 in the activation of human T cells. J. Clin. Immunol. 4:165-173, 1984.
12. Weiss, A. and Stobo, J.: Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell. J. Exp. Med. 160:1284-1299, 1984.
13. Wiskocil, R., Weiss, A., Imboden, J., Kamin-Lewis, R. and Stobo, J.: Activation of a human T cell line: A two stimulus requirement in the pre-translational events involved in the coordinate expression of interleukin-2 and γ-interferon genes. J. Immunol. 134:1599-1603, 1985.
14. Imboden, J., Weiss, A. and Stobo, J.: The antigen receptor of a T cell line initiates activation by increasing cytoplasmic free calcium. J. Immunol. 134:663-665, 1985.
12 Arthur Weiss, M.D., Ph.D.
15. Ohashi, P., Mak, T., Van den Elsen, P., Yanagi, Y., Yasunobu, Y., Calman, A., Terhorst, C., Stobo, J. and Weiss, A.: Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer. Nature 316:606-609, 1985.
16. Manger, B., Weiss, A., Weyand, C., Goronzy, J. and Stobo, J.: T cell activation: Differences in the signals required for IL-2 production by nonactivated and activated T cells. J. Immunol. 135:3669-3673, 1985.
17. Manger, B., Weiss, A., Hardy, K. and Stobo, J.: A transferrin receptor antibody represents one signal for the induction of IL-2 production by a human T cell line. J. Immunol. 136:532-538, 1986.
18. Manger, B., Hardy, K., Weiss, A. and Stobo, J.: Differential effect of cyclosporin A on activation signaling in human T cell lines. J. Clin. Invest. 77:1501-1506, 1986.
19. Weiss, A., Manger, B. and Imboden, J.: Synergy between the T3/antigen receptor complex and Tp44 in the activation of human T cells. J. Immunol. 137:819-825, 1986.
20. Lanier, L., Ruitenberg, J., Allison, J. and Weiss, A.: Distinct epitopes on the T-cell antigen receptor of HPB-ALL tumor cells identified by monoclonal antibodies. J. Immunol. 137:2286-2292, 1986.
21. Weiss, A., Newton, M. and Crommie, D.: Expression of T3 in association with a molecule distinct from the T cell antigen receptor heterodimer. Proc. Natl. Acad. Sci. USA 83:6998-7002, 1986.
22. Manger, B., Weiss, A., Imboden, J., Laing, T. and Stobo, J.: The role of protein kinase C in transmembrane signaling by the T cell antigen receptor complex: Effects of stimulation with soluble or immobilized T3 antibodies. J. Immunol. 139:2755-2760, 1987.
23. Durand, D.B., Bush, M.R., Morgan, J.G., Weiss, A. and Crabtree, G.R.: A 275 BP fragment at the 5' end of the IL-2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor. J. Exp. Med. 165:395-407, 1987.
24. Lancki, D.W., Weiss, A. and Fitch, F.W.: Requirements for triggering of lysis by CTL clones. J. Immunol. 138:3646-3653, 1987.
25. Weiss, A., Shields, R., Newton, M., Manger, B. and Imboden, J.: Ligand-receptor interactions required for commitment to the activation of the interleukin-2 gene. J. Immunol. 138:2169-2176, 1987.
26. Saito, T., Weiss, A., Miller, J., Norcross, M.A. and Germain, R.N.: Specific antigen-Ia activation of transfected human T cells expressing murine Ti α/β-human T3 receptor complexes. Nature 325:125- 130, 1987.
27. Lanier, L.L. and Weiss, A.: Presence of Ti (WT31) negative T lymphocytes in normal blood and thymus. Nature 324:268-270, 1987.
28. Lanier, L.L., Federspiel, N.A., Ruitenberg, J.J., Phillips, J.H., Allison, J.P., Littman, D. and Weiss, A.: The T cell antigen receptor complex expressed on normal peripheral blood CD4, CD8- T lymphocytes: A CD3-associated disulfide-linked γ-chain heterodimer. J. Exp. Med. 165:1076-1094, 1987.
29. Littman, D., Newton, M., Crommie, D., Ang, S-L., Seidman, J.G., Gettner, S. and Weiss, A.: Characterization of an expressed CD3-associated Ti γ chain reveals C γ domain polymorphism. Nature 326:85-88, 1987.
13 Arthur Weiss, M.D., Ph.D.
30. Gunter, K.C., Germain, R.N., Kroczek, R.A., Saito, T., Yokoyama, W.M., Chan, C., Weiss, A. and Shevach, E.M.: Thy-1 mediated T cell activation requires co-expression of the T3/Ti complex. Nature 326:505-507, 1987.
31. Pelicci, P.G., Subar, M., Weiss, A., Dalla-Favera, R. and Littman, D.R.: Molecular diversity of the human T-γ constant region genes. Science, 237:1051-1055, 1987.
32. Weiss, A., Dazin, P., Shields, R., Fu, S.M. and Lanier, L.L.: Functional competancy of T cell antigen receptors in human thymus. J. Immunol. 139:3245-3250, 1987.
33. Goldsmith, M.A. and Weiss, A.: Isolation and characterization of a T cell somatic mutant with altered signal transduction by the antigen receptor. Proc. Natl. Acad. Sci. USA, 84:6879-6883, 1987.
34. Lanier, L.L., Serafini, A.T., Ruitenberg, J.J., Cwirla, S., Federspiel, N.A., Phillips, J.H., Allison, J.P. and Weiss, A.: The gamma T cell antigen receptor. J. Clin. Immunol. 7:429-440, 1987.
35. Havran, W.L., Poenie, M., Kimura, J., Tsien, R., Weiss, A. and Allison, J.P.: Expression of functional activity of the CD3/antigen receptor on murine CD4+8+ thymocytes. Nature. 330:170-173, 1987.
36. Phillips, J.H., Weiss, A., Gemlo, B.T., Rayner, A.A. and Lanier, L.L.: Evidence that the T cell antigen receptor may not be involved in cytotoxicity mediated by γ/δ and α/β thymic cell lines. J. Exp. Med. 166:1579-1584, 1987.
37. Saito, T., Weiss, A., Gunter, K.C., Shevach, E.M. and Germain, R.N.: Cell surface T3 expression requires the presence of both γ, α and β chains of the T cell receptor. J. Immunol. 139:625-628, 1987.
38. Loh, E.Y., Lanier, L.L., Turck, C.W., Littman, D.R., Davis, M.M., Chien, Y.-H. and Weiss, A.: Identification and sequence of a fourth human T cell antigen receptor chain. Nature 330:569-572, 1987.
39. Bonyhadi, M., Weiss, A., Tucker, P.W., Tigelaar, R.E. and Allison, J.P.: Delta is the Cx-gene product in the γ/δ antigen receptor of dendritic epidermal cells. Nature 330:574-576, 1987.
40. Imboden, J.B. and Weiss, A.: The T cell antigen receptor regulates sustained increases in cytoplasmic free calcium through extracellular Ca2+ mobilization. Biochem. J. 247:695-700, 1987.
41. Laing, T.J. and Weiss, A.: IL-2 independent proliferation in human T cells. J. Immunol. 140:1056-1062, 1988.
42. Goldsmith, M. and Weiss, A.: Early signal transduction by the antigen receptor without commitment to T cell activation. Science 240:1029-1031, 1988.
43. Bockenstedt, L.K., Goldsmith, M.A., Dustin, M., Olive, D., Springer, T.A. and Weiss, A.: The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor. J. Immunol. 141:1904-1911, 1988.
44. Goldsmith, M.A., Dazin, P.F. and Weiss, A.: At least two non-antigen-binding molecules are required for signal transduction by the T cell antigen receptor. Proc. Natl. Acad. Sci. USA, 85:8613-8617, 1988.
45. Morley, B.J., Chin, K.N., Newton, M.E. and Weiss, A.: The lysine residue in the membrane-spanning domain of the β chain is necessary for cell surface expression of the T cell antigen receptor. J. Exp. Med. 168:1971-1978, 1988.
14 Arthur Weiss, M.D., Ph.D.
46. Koretzky, G., Wahi M., Newton, M.E. and Weiss, A.: Heterogeneity of protein kinase C isoenzyme gene expression in human T cell lines: Protein kinase C-β is not required for several T cell functions. J. Immunol. 143:1692-1695, 1989.
47. Goldsmith, M.A., Desai, D., Schultz, T. and Weiss, A.: Function of a heterologous muscarinic receptor in T cell antigen receptor signal transduction mutants. J. Biol. Chem. 264:17190-17197, 1989.
48. Fraser, J.D., Goldsmith, M.A. and Weiss, A.: Ligand-induced association between the T-cell antigen receptor and two glycoproteins. Proc. Natl. Acad. Sci. USA, 86:7133-7137, 1989.
49. Desai, D.M., Goldsmith, M.A. and Weiss, A.: A transfected human muscarinic receptor fails to substitute the T cell antigen receptor complex in CD2-initiated signal transduction. International Immunol. 2:615-620, 1990.
50. Koretzky, G.A., Picus, J., Thomas, M.L. and Weiss, A.: Tyrosine phosphatase CD45 is essential for coupling of the T cell antigen receptor to the phosphatidylinositol second messenger pathway. Nature 346:66-68, 1990.
51. Geisler, C., Scholler, J., Wahi, M.A., Rubin, B. and Weiss, A.: Association of the human CD3-γ chain with the αβTCR/CD3 complex. J. Immunol. 145:1761-1767, 1990.
52. Desai, D.M., Newton, M.E., Kadlecek, T. and Weiss, A.: Stimulation of the phosphatidylinositol pathway can induce T cell activation. Nature 348:66-69, 1990.
53. Koretzky, G.A., Picus, J., Schultz, T. and Weiss, A.: Tyrosine phosphatase CD45 is required for T cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production. Proc. Natl. Acad. Sci. USA 88:2037-2041, 1991.
54. Fraser, J.D., Irving, B.A., Crabtree, G.R. and Weiss, A.: Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251:313-316, 1991.
55. Irving, B.A. and Weiss, A.: The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways. Cell 64:891-901, 1991.
56. Graber, M., Bockenstedt, L.K. and Weiss, A.: Signalling via the inositol phospholipid pathway by T cell antigen receptor is limited by receptor number. J. Immunol. 146:2935-2943, 1991.
57. Weiss, A., Koretzky, G. and Kadlecek, T.: Stimulation of the T cell antigen receptor induces tyrosine phosphorylation of phospholipase Cγ1. Proc. Natl. Acad. Sci. USA 88:5484-5488, 1991.
58. Tan, L., Turner, J. and Weiss, A.: Regions of the T cell antigen receptor α and β chains that are responsible for interactions with CD3. J. Exp. Med. 173:1247-1256, 1991.
59. Chan, A.C., Irving, B.A., Fraser, J.D. and Weiss, A.: The ζ-chain is associated with a tyrosine kinase and upon T cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. Proc. Natl. Acad. Sci. USA 88: 9166-9170, 1991.
60. Margolis, B., Hu, P., Katzav, S., Li, W., Oliver, J.M., Ullrich, A., Weiss, A. and Schlessinger, J.: Tyrosine phosphorylation of vav; proto-oncogene product containing SH2 domain and transcription factor motifs . Nature 356:71-74, 1992.
15 Arthur Weiss, M.D., Ph.D.
61. Fraser, J.D., Newton, M.E. and Weiss, A.: CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen expression. J. Exp. Med. 175:1131-1134, 1992.
62. Koretzky, G.A., Kohmetscher, M.A., Kadlecek, T. and Weiss, A.: Restoration of T cell receptor mediated signal transduction by transfection of CD45 into a CD45-deficient variant of the Jurkat T cell line. J. Immunol., 149:1138-1142, 1992.
63. Straus, D.B. and Weiss, A.: Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Cell 70:585-593, 1992.
64. Fraser, J.D. and Weiss, A.: Regulation of T cell lymphokine transcription by the accessory molecule CD28. Mol. Cell. Biol., 12:4357-4363, 1992.
65. Graber, M., June, C.H., Samelson, L.E. and Weiss, A.: The protein tyrosine kinase inhibitor herbimycin A, but not genistein, specifically inhibits signal transduction by the T cell antigen receptor. International Immunol., 4:1201-1210, 1992.
66. Chan, A.C., Iwashima, M., Turck, C.W. and Weiss, A.: ZAP-70: A 70kD protein tyrosine kinase that associates with the TCR ζ chain. Cell 71:649-662, 1992.
67. Sieh, M., Bolen, J.B. and Weiss, A.: CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine Lck. EMBO J., 12:315-321, 1993.
68. Irving, B.A., Chan, A.C. and Weiss, A.: Functional characterization of a signal transducing motif present in the T cell antigen receptor ζ chain. J. Exp. Med., 177:1093-1103, 1993.
69. Desai, D.M., Sap, J., Schlessinger, J. and Weiss, A.: Ligand-mediated negative regulation of a chimeric transmembrane receptor CD45 tyrosine phosphatase. Cell 73:541-554, 1993.
70. Straus, D. and Weiss, A.: The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated following receptor stimulation. J. Exp. Med., 178:1523-1530, 1993.
71. van Oers, N.S.C., Teh, S.J., Irving, B.A., Tiong, J., Weiss, A. and Teh, H.-S.: Production and characterization of monoclonal antibodies specific for the murine T cell receptor ζ chain. J. Immunol. Meth. 170:261-268, 1994.
72. Iwashima, M., Irving, B.A., van Oers, N.S.C., Chan, A.C. and Weiss, A.: Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 263:1136-1139, 1994.
73. Chan, A.C., van Oers, N.S., Tran, A., Turka, L., Law, C-L., Ryan, J.C., Clarke, E.A. and Weiss, A.: Differential expression of ZAP-70 and Syk protein tyrosine kinases, and role of this family of protein tyrosine kinases in T cell antigen receptor signaling. J. Immunol. 152:4758-4766, 1994.
74. Law, C-L., Sidorenko, S.P., Chandran, K.A., Draves, K.E., Chan, A.C., Weiss, A., Edelhoff, S., Disteche, C.M. and Clark, E.A.: Molecular cloning of human Syk: A B cell protein tyrosine kinase associated with the slgM/B cell receptor complex. J. Biol. Chem., 269:12310-12319, 1994.
75. Stein, P.H., Fraser, J.D. and Weiss, A.: The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'- kinase. Mol. Cell. Biol., 14:3392-3402, 1994.
16 Arthur Weiss, M.D., Ph.D.
76. Chan, A.C., Kadlecek, T., Elder, M.E., Filipovich, A.H., Kuo, W-L., Iwashima, M., Parslow, T.G. and Weiss, A.: ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency. Science 264:1599-1601, 1994.
77. Elder, M.E., Lin, D., Clever, J., Chan, A.C., Hope, T.J., Weiss, A. and Parslow, T.G.: Human severe combined immunodeficiency due to a defect in ZAP-70--A T-cell receptor-linked tyrosine kinase. Science 264:1596-1599, 1994.
78. Gupta, S., Weiss, A., Kumar, G., Wang, S., and Nel, A.: The T-cell antigen receptor utilizes LCK, RAF- 1 and MEK-1 for activating MAP kinase: Evidence for the existence of a second PKC-dependent pathway in an LCK-negative Jurkat cell mutant. J. Biol. Chem. 269:17349-17357, 1994.
79. Desai, D.M., Sap, J., Silvennoinen, O., Schlessinger, J. and Weiss, A.: The catalytic activity of the CD45 membrane proximal phosphatase domain is required for TCR signaling and regulation. EMBO J. 13:4002-4010, 1994.
80. Sieh, M., Batzer, A., Schlessinger, J. and Weiss, A.: GRB2 and phospholipase C-γ1 associate with a 36- to 38-Kilodalton phosphotyrosine protein after T-cell receptor stimulation. Mol. Cell. Biol. 14:4435- 4442, 1994.
91. van Oers, N.S.C., Killeen, N. and Weiss, A.: ZAP-70 is constitutively associated with tyrosine phosphorylated TCR ζ in murine thymocytes and lymph node T cells. Immunity 1:675-685, 1994.
82. Katzav, S., Sutherland, M., Packham, G., Yi, T. and Weiss, A.: The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav. J. Biol. Chem. 269:32579-32585, 1994.
83. Gelfand, E.W., Weinberg, K., Mazer, B.D., Kadlecek, T.A. and Weiss, A.: Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not thymocytes. J. Exp. Med. 182:1057-1066, 1995.
84. Wu, J., Katzav, S. and Weiss, A.: A functional T cell receptor signaling pathway is required for p95vav activity. Mol. Cell. Biol. 15:4337-4346, 1995.
85. van Oers, N.S.C., von Boehmer, H. and Weiss, A.: The Pre-TCR complex is functionally coupled to the TCR ζ subunit. J. Exp. Med. 182:1585-1590, 1995.
86. Crooks, M.E.C., Littman, D.R., Carter, R.H., Fearon, D.T., Weiss, A. and Stein, P.H.: CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation. Mol. Cell. Biol. 15:6820-6828, 1995.
87. Fargnoli, J., Burkhardt, A.L., Laverty, M., Kut, S.A., van Oers, N.S.C., Weiss, A. and Bolen, J.B.: Syk mutation in Jurkat E6-derived clones results in lack of p72syk expression. J. Biol. Chem. 270:26533- 26537, 1995.
88. Straus, D.B., Chan, A.C., Patai, B. and Weiss, A.: SH2 domain function is essential for the role of the Lck tyrosine kinase in T cell receptor signal transduction. J. Biol. Chem. 271:9976-9981, 1996.
89. Qian, D., Mollenauer, M.N. and Weiss, A.: Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling. J. Exp. Med. 183:611-620, 1996.
90. van Oers, N.S.C., Killeen, N. and Weiss, A.: Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes. J. Exp. Med. 183:1053-1062, 1996.
17 Arthur Weiss, M.D., Ph.D.
91. Wu, J., Motto, D.G., Koretzky, G.A. and Weiss, A.: Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity, 4:593-602, 1996.
92. Fry, A.M., Lanier, L.L. and Weiss, A.: Phosphotyrosines in the KIR motif of NKB1 are required for negative signaling and for association with PTP1C. J. Exp. Med., 184:295-299, 1996.
93. van Oers, N.S.C., Lowin-Kropf, B., Finlay, D., Connolly, K. and Weiss, A.: αβ T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity, 5:429-436, 1996.
94. Chu, D.H., Spits, H., Peyron, J-F., Rowley, R.B., Bolen, J.B. and Weiss, A.: The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling. EMBO J., 15:6251-6261, 1996.
95. Taylor, N., Bacon, K.B., Smith, S., Jahn, T. Kadlecek, T.A., Uribe, L., Kohn, D.B., Gelfand, E.W., Weiss, A. and Weinberg, K.: Reconstitution of T cell receptor signaling in ZAP-70 deficient cells by retroviral transduction of the ZAP-70 gene. J. Exp. Med., 184:2031-2036, 1996.
96. Zhao, Q. and Weiss, A.: Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70. Mol. Cell. Biol., 16:6765-6774, 1996.
97. Shapiro, V.S., Mollenauer, M.N., Greene, W.C. and Weiss, A.: c-Rel regulation of IL-2 gene expression may be mediated through activation of AP-1. J. Exp. Med. 184:1663-1669, 1996.
98. Qian, D., Lev, S., van Oers, N.S.C., Dikic, I., Schlessinger, J. and Weiss, A.: Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling. J. Exp. Med. 185:1253-1259, 1997.
99. Page, S.T., van Oers, N.S.C., Perlmutter, R.M., Weiss, A. and Pullen, A.: Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development. Eur. J. Immunol., 27:554-562, 1997.
100. Wu, J., Zhao, Q. Kurosaki, T. and Weiss, A.: The Vav binding site (Y315) in ZAP-70 is critical for antigen receptor-mediated signal transduction. J. Exp. Med. 185:1877-1882, 1997.
101. Shapiro, V.S., Truitt, K.E., Imboden, J.B. and Weiss, A.: CD28 mediates transcriptional upregulation of the IL-2 promoter through a composite element containing the CD28RE and NF-IL-2B Ap-1 sites. Mol. Cell Biol. 17:4051-4058, 1997.
102. Huby, R.D.J., Iwashima, M., Weiss, A., and Ley, S.C.: ZAP-70 protein tyrosine kinase is constitutively targeted to the T cell cortex independently of its SH2 domains. J. Cell. Biol. 137:1639-1649, 1997.
103. Liao, X.C., Fournier, S., Killeen, N., Weiss, A.: Allison, J.P. and Littman, D.R.: Itk negatively regulates induction of T cell proliferation by CD28 costimulation. J. Exp. Med. 186:221-228, 1997.
104. Petricoln III, E., Sastoshi, I., Williams, B.L., Audet, S., Stancato, L.F., Gamero, A., Clouse, K., Grimley, P., Weiss, A., Beeler, J., Finbloom, D.S., Shores, E.Q., Abraham, R., and Larner, A.C.: Antiproliferative action of interferon-α requires components of T-cell receptor signalling. Nature, 390:629-632, 1997.
105. Liao, X.C., Littman, D.R., Weiss, A.: Itk and Fyn make independent contributions to T cell activation. J. Exp. Med., 186:2069-2073, 1997.
106. Lowin-Kropf, B., Shapiro, V.S., and Weiss, A.: Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism. J. Cell Biol. 140:861-871, 1998.
18 Arthur Weiss, M.D., Ph.D.
107. van Oers, N., Love, P.E., Shores, E.W., Weiss, A.: Regulation of TCR signal transduction in murine thymocytes by multiple TCR-ζ chain signaling motifs. J. Immunol., 160:163-170, 1998.
108. Majeti, R., Bilwes, A.M., Noel, J.P., Hunter, T. and Weiss, A.: Dimerization induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge. Science, 279:88-91, 1998.
109. Grazioli, L., Germain, V., Weiss, A., Acuto, O.: Anti-peptide antibodies detect conformational changes of the inter-SH2 domain of ZAP-70 due to binding to the ζ chain and to intramolecular interactions. J. Biol. Chem., 273:8916-8921, 1998.
110. Huby, R.D.J., Weiss, A. and Ley, S.C.: Nocodazole inhibits signal transduction by the T cell antigen receptor. J. Biol. Chem., 273:12024-12031, 1998.
111. Yablonski, D., Kuhne, M.R., Kadlecek. T. and Weiss, A. Uncoupling of non-receptor tyrosine kinases from PLC-γ1 in a SLP-76-deficient T cell. Science, 281:413-416,1998.
112. Finco, T.S., Kadlecek, T, Zhang, W., Samelson, L.E. and Weiss, A.: LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway. Immunity, 9:617-626, 1998.
113. Kadlecek, T.A., van Oers, N.S.C., Lefrancois, L., Olson, S., Finlay, D., Chu, D.H., Connolly, K., Killeen, N. and Weiss, A. : Differential requirements for ZAP-70 in TCR signaling and T cell development. J. Immunol., 161:4688-4694, 1998.
114. Yablonski, D., Kane, L.P., Qian, D. and Weiss, A.: An Nck-Pak1 signaling module is required for T cell receptor-mediated activation of NFAT, but not JNK. EMBO J., 17:5547-5657, 1998.
115. Smith, V.S., Mollenauer, M.N. and Weiss, A: NFAT and AP-1 are insufficient for IL-2 promoter activation: requirement for CD28 upregulation of RE/AP. J. Immunol. 161:6455-6458, 1998.
116. Finco, T.S., Kadlecek, T., Zhang, W., Samelson, L.E., and Weiss, A.: LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway. Immunity 9:617-629, 1998.
117. Zhao, Q., Williams, B.L., Abraham, R.T. and Weiss, A: Interdomain B in ZAP-70 regulates but is not required for its signaling function in lymphocytes. Mol. Cell. Biol., 19:948-956, 1999.
118. Chu, D.H., van Oers, N.S.C., Malissen, M., Harris, J., Elder, M. and Weiss, A.: Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression. J. Immunol., 163:2610-2620, 1999.
119. Lagunoff, M., Majeti, R., Weiss, A. and Ganem, D.: Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus. Proc. Natl. Acad. Sci. USA 96:5704-5709, 1999.
120. Kane, L.P., Shapiro, V.S., Stokoe, D. and Weiss, A.: Induction of NF-κB by the Akt/PKB kinase. Curr. Biol., 9:601-604, 1999.
121. Lin, J., Weiss, A. and Finco, T.S.: Localization of LAT in glycolipid-enriched microdomains is required for T cell activation. J. Biol., Chem., 274: 28861-28864, 1999.
122. Lynch, K.W. and Weiss, A.: A model system for activation-induced alternative splicing of CD45 pre- mRNA in T cells implicates PKC and Ras. Mol. Cell. Biol., 20:70-80, 2000.
19 Arthur Weiss, M.D., Ph.D.
123. Witherden, D., van Oers, N., Waltzinger, C., Weiss, A. Benoist, C., and Mathis, D.: Tetracycline- controllable selection of CD4+ cells: Half-life and survival signals in the absence of major histocompatibility complex Class II molecules. J. Exp. Med., 191:355-364, 2000.
124. Kuhne, M.R., Ku, G. and Weiss, A.: A Guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation. J. Biol. Chem., 275:2185-2190, 2000.
125. Sosinowski, T., Pandey, A., Dixit, V.M., and Weiss, A.: Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. J. Exp. Med., 191:463-473, 2000.
126. Liou, J., Friedemann, K., Dang, A., Hashimoto, A., Cobb, M.H., Kurosaki, T. and Weiss, A: HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1. Immunity, 12:399-408, 2000.
127. Genot, E.M., Arrieumerlou, C., Ku, G., Burgering, B.M.T., Weiss, A., and Kramer, I.M.: The T-cell receptor regulates Akt (protein kinase) via a pathway involving Rac1 and phosphatidylinositide 3-kinase. Mol. Cell. Biol., 20:5469-5478,2000.
128. Majeti, R., Parslow, T.G., Olson, J.L., Daikh, D.I., Killeen, and Weiss, A.: An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell, 103:1059-1070, 2000.
129. Elder, M.E., Skoda-Smith, S., Kadlecek, T.A., Wang, F., Wu, J. and Weiss, A.: Distinct T cell development consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70. J. Immunol. 166:656-661, 2001.
130. Kane, L.P., Andres, P.G., Abbas, A.K., and Weiss, A.: Akt, acting through the RE/AP element, provides the CD28 co-stimulatory signal for upregulation of IL-2 but not Th2 cytokines. Nature Immunol, 2:37-44, 2001.
131. Ku, G., Yablonski, D., Manser, E., Lim, L. and Weiss, A.: A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. EMBO J., 20:457-465, 2001.
132. Baker, J.E., Majeti, R., Tangye, S.G., and Weiss, A.: Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cγ1 phosphorylation. Mol. Cell. Biol. 21:2393-2403, 2001.
133. Kratchmarova, I., Sosinowski, T., Weiss, A., Witter, K., Vincenz, C., and Pandey, A.: Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein. Gene, 262:267-273, 2001.
134. Yablonski, D., Kadlecek, T., and Weiss, A.: Identification of a PLC-γ1 SH3 domain-binding site in SLP- 76, required for TCR-mediated activation of PLC-γ1 and NFAT. Mol. Cell Biol., 21:4208-4218, 2001.
135. Lynch, K.W. and Weiss, A.: A CD45 polymorphism associated with multiple sclerosis disrupts an exonic splicing silencer, J. Biol. Chem., 276:24341-24247, 2001.
136. Arnold, R., Liou, J., Drexler, H.C.A., Weiss, A., and Kiefer, F.: Caspase-mediated cleavage of hematopoietic progenitor kinase 1 (HPK1) converts an activator of NFκB into an inhibitor of NFκB. J. Biol. Chem., 276:14675-14684, 2001.
137. Lin, J. and Weiss, A.: Identification of the minimal tyrosine residues required for linker for activation of T cell function. J. Biol. Chem. 276:29588-29595, 2001.
20 Arthur Weiss, M.D., Ph.D.
138. Sosinowski, T., Killeen, N., and Weiss, A.: The Src-like adaptor protein downregulates T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. Immunity, 145:457-466, 2001.
139. Sauer, K.*, Liou, J.*, Singh, S.B., Yablonski, D., Weiss, A., and Perlmutter, R.: The Kinase HPK1 associates physically and functionally with the adaptor proteins BLNK and SLP-76 in lymphocytes. J. Biol. Chem., 276:45207-45216, 2001. *co-first authors
140. Bromley, S.K., Iaboni, A., Davis, S.J., Whitty, A., Green, J.M., Shaw, A.S., Weiss, A. and Dustin, M.L.: The immunological synapse and CD28-CD80 interactions. Nature Immunol. 2:1159-1166, 2001.
141. Barcellos L.F., Caillier, S., Dragone, L., Elder, M., Vittinghoff, E., Bucher, P., Lincoln R.R., Pericak-Vance, M., Haines, J.L., Weiss, A., Hauser, S.L., Oksenberg, J.R. PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients. Nat Genet. 1:234-236. 2001.
142. Xu, Z., Stokoe, D., Kane, L.P. and Weiss, A.: The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells. Cell Growth & Different., 13:285-296, 2002.
143. Xu, Z., Weiss, A.: Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms. Nat. Immunol., 3:764-771, 2002.
144. Kane, L.P., Mollenauer, M.N., Xu, Z., Turk, C.W., and Weiss, A.: Akt-dependent phosphorylation specifically regulates Cot induction of NF-κB dependent transcription. Mol. Cell. Biol., 22:5962-5974, 2002.
145. Chen, L., Huynh, L., Rassenti, L., Widhopf, G., Rai, K.R., Weiss, A., and Kipps T.J. Expression of ZAP- 70 in B cell chronic lymphocytic leukemia, Blood, 100:4609-4614, 2002.
146. Richie Erlich, L.I., Ebert, P.J.R., Krummel, M.F., Weiss, A., and Davis, M.M. Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity, 17:809-822, 2002.
147. Kuhne, M.R., Lin, J., Yablonski, D., Richie, L.I., Huppa, J., Davis, M.M., and Weiss. A. LAT, ZAP-70 and SLP-76 are required for TCR-induced MTOC polarization. J. Immunol., 171:860-866, 2003.
148. Hargrove, L., Lin, J., Langen, H., Zech, T., Weiss, A., and Harder, T. Synergistic assembly of LAT signalling protein complexes in T cell plasma membrane domains. J. Biol. Chem., 278:20389-20394, 2003.
149. Lin, J., and Weiss, A. The tyrosine phosphatase CD148 is excluded fromt he immunologic synapse and downregulates prolonged T cell signaling. J. Cell Biol., 162:673-682, 2003.
150. Roose, J.P., Diehn, M., Tomlinson, M.G., Lin, J., Alizadeh, A.A., Botstein, D., Brown, P.O., and Weiss, A. T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PloS Biology, 1:271-287, 2003
151. Tomlinson, M.G., Kane, L.P., Su, J., Kadlecek, T.A., Mollenauer, M.N., and Weiss, A. Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec. Mol. Cell. Biol., 24:2455-2466, 2004.
21 Arthur Weiss, M.D., Ph.D.
152. Andres, P., Howland, K.C., Nirula, A., Kane, L.P., Barron, L., Dresnek, D, Sadra, A., Imboden, J., Weiss, A., and Abbas, A.K. Distinct regions in the CD28 domain are required for TH2 differentiation. Nature Immunol., 5:435-442, 2004.
153. Crotzer, V.L., Mabardy, A.S., Weiss, A., and Brodsky, F.M. T cell receptor regulates its own down- modulation through Lck phosphorylation of clarthrin. J. Exp. Med., 199:981-991, 2004.
154. Kane, L.P., Mollenauer, M.N., and Weiss, A. A proline-rich motif in the carboxy terminus of Akt contributes to its localization in the immunological synapse. J. Immunol. 172:5441-5449, 2004.
155. Lin, J., Zhu, J.W., Baker, J.E., and Weiss, A. Regulated expression of the receptor-like tyrosine phosphatase CD148 on hematopoietic cells. J. Immunol. 173:2324-2330. 2004.
156. Rassenti, L.Z., Huynh, L., Toy, T.L., Chen, L., Gribben, J.G., Keating, M.J., Rai, K.R., Finn, I.W., Byrd, J.C., Kay, N.E., Greaves, A., Weiss, A., Kipps, T.J. ZAP-70 compared with immunoglobulin heavy- chain mutation status as a predictor of disease progression in chronic lymphocytic leukemia. N. Eng. J. Med., 351:893-901. 2004.
157. Tomlinson, M.G., Heath, V.L., Turck, C.W., Watson, S.P., and Weiss, A. SHIP family of inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase. J. Biol. Chem. 279:55089- 55096, 2004.
158. Chen, L. Apgar, J., Huynh, L., Dicker, F., Giago-McGahan, T., Rassenti, L, Weiss, A. and Kipps, T.J. ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia. Blood 105:2036-2041, 2004.
159. Roose, J.P., Mollenauer, M., Gupta, V., Stone, J., and Weiss, A. A diacylglycerol-PKC-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol. Cell. Biol. 25:4426- 4441, 2005.
160. Phee, H., Abraham, R., and Weiss, A. Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1. Nature Immunol. 6:608-617, 2005.
161. Brdicka, T., Kadlecek, T.A., Roose, J.P., Pastuszak, A.W., and Weiss, A. Intramolecular regulatory switch in ZAP-70: analogy to with receptor tyrosine kinases. Mol. Cell. Biol. 25:4924-4933, 2005.
162. Myers, M.D., Dragone, L.L., and Weiss, A. Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRζ for degradation. J. Cell Biol. 170:285-294, 2005.
163. Hermiston, M., Tan, A.L., Gupta, V.A., Majeti, R., and Weiss, A. The juxtamembrane wedge negatively, regulates CD45 function in B cells. Immunity 23:635-647, 2005.
164. Myers, M.D., Sosinowski, T., Dragone, L.L., White, C., Band, H., Gu, H., and Weiss, A. Src-like adaptor protein regulates TCR expression on thymocytes by adapting c-Cbl to the TCR complex. Nature Immunol., 7:57-66, 2006.
165. Dragone, L.L., Myers, M.D., White, C., Sosinowski, T., and Weiss, A. Src-like adaptor protein regulates B cell development and function. J. Immunol., 176:335-345, 2006.
166. Hesslein, D.G.T., Takaki, R., Hermiston, M.L., Weiss, A., and Lanier, L.L. Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production. Proc. Nat. Acad. Sci., USA, 103:7012-7017, 2006.
22 Arthur Weiss, M.D., Ph.D.
167. Nirula, A., Ho, M., Phee, H., Roose, J., and Weiss, A. Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4. J. Exp. Med. 203:1733-1744, 2006.
168. Dragone, L.L., Myers, M.D., White, C., Gadwal, S., Sosinowski, T., Gu, H., and Weiss. A. Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner. Proc. Natl. Acad. Sci., USA, 103:18202-18207, 2006.
169. Balachandran, P., Dragone, L., Garrity-Ryan, L., Weiss, A., and Engel, J. Pseudomonas aeroginosa exotoxin T-mediated virulence is limited by the ubiquitin ligase Cbl-b. J. Clin. Invest., 117:419-427, 2007.
170. Roose, J.P., Mollenauer, M., Ho, M., Kurosaki, T., and Weiss, A. Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes, Mol. Cell. Biol., 27:2732-2735, 2007.
171. Chung, S.A., Limnander, A., Kurosaki, T., Weiss, A., and Korenbrot, J.I. Coupling Ca2+ store release to Icrac channel activation requires the activity of Lyn and Syk kinases in B lymphocytes. J. Cell Biol. 177:317-328, 2007.
172. Deindl, S., Kadlecek, T.A. , Brdicka, T., Cao, X., Weiss, A., and Kuriyan. Structural basis for the inhibition of the tyrosine kinase activity of ZAP-70. Cell, 129:735-746, 2007.
173. Schmalzigaug, R., Phee, H., Davidson, C., Weiss, A., and Premont, R. Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues. J. Hisochem. and Cytochem., 55:1039-1048, 2007.
174. Palacios, E., and Weiss, A. Distinct roles for Syk and ZAP-70 during thymic development. J. Exp. Med., 204:1703-1715, 2007.
175. Chen, L., Huynh, L., Apgar, J., Tang, L., Rassenti, L., Weiss, A., and Kipps, T.J. ZAP-70 enhances IgM signaling independent of it kinase activity in chronic lymphocytic leukemia. Blood, 111:2685-2692, 2007.
176. Siggs, O.M., Miosge, L.A., Yates, A.L., Kucharska, E.M., Sheahan, D., Brdicka, T., Weiss, A., Liston, A., and Goodnow, C.C. Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate response to nucleotide substitutions. Immunity. 27:912-926. 2007.
177. Zhu, J.W.*, Brdicka, T.*, Katsumoto, T.R., Lin, J. and Weiss, A. Structurally distinct phosphatases CD45 and CD148 regulate B cell and macrophage immunoreceptor signaling. Immunity. 28:183-196. 2008. * co-first authors
178. Levin, S.E., Zhang, C., Kadlecek, T.A., Shokat, K. and Weiss, A. Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling. J. Biol. Chem. 283:15419-15430. 2008.
179. Mingueneau, M., Sansoni, A., Gregoire, C., Roncagalli, R., Aguado, E., Weiss, A., Malissen, M., and Malissen, B. The proline-rich sequence of CD3e controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes. Nature Immunol., 9:522-32. 2008.
180. Gupta, V.A., Hermiston, M.L., Cassafer, G., Daikh, D.I., and Weiss, A. B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency. J. Exp. Med., 205:2755-61. 2008.
23 Arthur Weiss, M.D., Ph.D.
181. Prasad, A., Zikherman, J., Das, J., Roose, J.P., Weiss, A. and Chakraborty A.K. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. Proc. Natl. Acad. Sci. USA, in press. 2008.
182. Louvet, C., Szot, G.L., Lang, J., Lee, M.R., Bolag, G., Zhu, S., Weiss, A. and Bluestone, J.A. Reversal and long term remission of type 1 diabetes in NOD mice treated with Imatinib. Proc. Natl. Acad. Sci. USA, 105:18895-18900. 2008.
183. Das, J., Ho, M., Zikherman, J., Govern, C., Yang, M., Weiss, A., Chakraborty, A.K., and Roose, J.P. Digital signaling and hysteresis characterize Ras activation in lymphoid cells. Cell. 136:337-351 2009.
184. Grochowy, G., Hermiston, M.L., Kuhny, M., Weiss, A. and Huber, M. Requirement for CD45 in fine- tuning mast cell responses mediated by different ligant-receptor systems. Cell Sig., 8:1277-1286. 2009.
185. Zikherman, J., Hermiston, M., Steiner, D., Hasegawa, K., Chan, A. and Weiss, A. PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. J. Immunol., 182:4093-4106. 2009.
186. Senis, Y.A., Tomlinson, M.G., Ellison, S., Mazharian, A., Lim, J., Zhao, Y, Kornerup, K.N., Auger, J.M., Thomas, S.G., Dhanjal, T., Kalia, N., Zhu, J.W., Weiss, A. and Watson, S.P. The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. Blood, 113:4942-4954. 2009.
188. Xavier, C., Gabay, J.E., Reyes, M., Zhu, J.W., Weiss, A., and Shuman, H.A. Chemical genetics reveals bacterial and host cell functions critical for type IV effector translocation by legionella pneumophilia. PLoS Path, July 5(7):e1000501, 2009.
189. Hsu, L.-Y., Tan, Y.X., Xiao, Z., Malissen, M., and Weiss, A. A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity. J. Exp. Med., 206:2527-2541, 2009
190. Deindl, S.*, Kadlecek*, T.A., Cao, X., Kuriyan, J., and Weiss. A. Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response. Proc. Natl. Acad. Sci. USA, 106:20699-20704, 2009. * co-first authors
191. Zikherman, J., Jenne, C., Watson, S., Doan, K., Raschke, W., Goodnow, C.C., and Weiss, A. The balance between positive and negative regulatory roles of CD45 during TCR signaling varies throughout T cell development. Immunity, 32:342-354. 2010.
192. Phee, H., Dzhagalov, I., Mollenauer, M., Wang, Y., Irvine, D.J., Robey, E., and Weiss, A. Regulation of thymocyte positive selection and motility by GIT2. Nat. Immunol., 11:503-511. 2010.
193. Beinke, S., Phee, H., Clingan, J.M., Schlessinger, J., Matloubian, M., and Weiss, A. Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector cells. Proc. Natl. Acad. Sci. USA 107:16234-16239. 2010.
194. Au-Yeung, B.B, Levin, S.E., Zhang, C., Hsu, L.-Y., Cheng, D., Killeen, N., Shokat, K.M., and Weiss. A. A genetically selective ZAP-70 kinase inhibitor reveals requirements for catalytic function in Treg cells. Nat. Immunol. 11:1085-1093. 2010.
24 Arthur Weiss, M.D., Ph.D.
NON-PEER REVIEWED PUBLICATIONS AND OTHER CREATIVE ACTIVITIES
1. Edidin, M. and Weiss, A.: Restriction of antigen mobility in the plasma membranes of some cultured fibroblasts. In Control of Proliferation in Animal Cells. Cold Spring Harbor Laboratory, p. 213, 1974.
2. Fitch, F.W., Weiss, A., McKearn, T.J. and Stuart, F.P.: Graft enhancement and anti-idiotypic antibody. Lymphocytes from long-term rat renal allograft recipients have normal responsiveness in vitrol. Transplant. Proc. 10:367-372, 1978.
3. McKearn, T.J., Sarmiento, M., Weiss, A., Stuart, F.P. and Fitch, F.W.: Selective suppression of reactivity to rat histocompatibility antigens by hybridoma antibodies. Curr. T. Micro. 81:61-65, 1978.
4. Weiss, A., Stuart, F.P. and Fitch, F.W.: Absence of immunologic memory in recipients of enhanced renal allografts. Surg. Forum 29:330-333, 1978.
5. McKearn, T.J., Weiss, A., Stuart, F.P. and Fitch, F.W.: Selective suppression of humoral and cell- mediated immune response to rat alloantigens by monoclonal antibodies produced by hybridoma cell lines. Transplant. Proc. 11:932-935, 1979.
6. Stuart, F.P., Weiss, A. and Fitch, F.W.: Induction and maintenance of immunologic enhancement in Immunological Tolerance and Enhancement. Ed. F.P. Stuart and F.W. Fitch, MTP Press Limited, p. 29, 1979.
7. Stuart, F.P., McKearn, T.J. , Weiss, A. and Fitch, F.W.: Suppression of rat renal allograft rejection by antigen and antibody. Immunological Reviews, p. 49, 1979.
8. Nabholz, M., Cianfriglia, M., Acuto, O., Conzelmann, A., Weiss, A., Haas, W. and von Boehmer, H.: The production of murine cytolytic T cell hybrids. In Monoclonal Antibodies and T Cell Hybridomas. Ed. G.H. Hammerling, V. Hammerling and F.P. Kearney. Elsevier/North-Holland Biomed. Press, p. 539- 547, 1981.
9. Brunner, K.T., Weiss, A., MacDonald, H.R. and Cerottini, J.-C.: Cytolytic T lymphocyte clones recognizing murine sarcoma virus-induced tumor antigens. In Isolation, Characterization and Utilization of T Lymphocyte Clones. Ed. C.G. Fathman and F.W. Fitch. Academic Press, p. 297, 1982.
10. Weiss, A., Hollander, H. and Stobo, J.: Acquired immunodeficiency syndrome: Epidemiology, virology and immunology. Ann. Rev. Med. 36:545-562, 1985.
11. Imboden, J., Weiss, A. and Stobo, J.: Transmembrane signalling by the T3-antigen-receptor complex requires an increase in cytoplasmic free calcium. Immunology Today 6:328-331, 1985.
12. Weiss, A., Imboden, J., Hardy, K., Manger, B., Terhorst, C. and Stobo, J.: The role of the T3/antigen receptor complex in T cell activation. Ann. Rev. Immunol. 4:593-619, 1986.
13. Weiss, A. and Imboden, J.B.: Cell surface molecules and early events involved in human T cell activation. Adv. Immunol. 41:1-38, 1987.
14. Allison, J.P., Havran, W.L., Poenie, M., Kimura, J., DeGraffenreid, L., Ajami, S., Duwe, G., Weiss, A. and Tsien, R.: Expression and function of CD3 on murine thymocytes. UCLA Symposium on Molecular and Cellular Biology, The T Cell Receptor, Volume 73, Ed. John Kappler and Mark Davis, Alan R. Liss, Inc., New York, NY, p. 33-45, 1987.
25 Arthur Weiss, M.D., Ph.D.
15. Bockenstedt, L.K., Goldsmith, M.A., Koretzky, G.A. and Weiss, A.: The activation of T lymhocytes. Rheumatic Disease Clinics of North America. 13:411-430, 1987.
16. Weiss, A., Imboden, J.B., Manger, B. and Stobo, J.D.: The role of the T3-antigen receptor complex in T cell activation. Human Inflammatory Disease, Clinical Immunology, Volume 1, Ed. G. Marone, L. Lichtenstein, M. Condorelli and A. Fauci. B.C. Decker Inc., Philadelphia, PA, pp 295-302, 1988.
17. Lanier, L.L., Ruitenberg, J.J., Allison, J.P. and Weiss, A.: Biochemical and flow cytometric analysis of CD3 and Ti expression on normal and malignant T-cells. Leucocyte Typing III, Ed. A.J. McMichael, Oxford University Press, New York, N.Y., pp 175-178, 1988.
18. Manger, B., Imboden, J. and Weiss, A.: The role of the T3/T-cell antigen receptor complex in human T cell activation in The T Cell Receptor. Ed. T. Mak. Plenum Press, pp 133-149, 1988.
19. Goldsmith, M.A. and Weiss, A.: New clues about T cell antigen receptor complex function. Immunology Today 9:220-222, 1988.
20. Imboden, J.B. and Weiss, A.: Regulation of interleukin-2 production by the T cell antigen receptor. Interleukin 2, Ed. K.A. Smith, Academic Press, Inc., San Diego, CA, 85-98, 1988.
21. Weiss, A.: The biology of the T lymphocytes. Textbook of Rheumatology. 3rd Edition. Ed. W. Kelley, E.D. Harris, S. Ruddy and C.B. Sledge. W.B. Saunders Co., Philadelphia, PA. pp 148-168, 1988.
22. Goldsmith, M.A. and Weiss, A.: Function of the antigen receptor in T cell activation. Biology of Growth Factors: Molecular Biology, Oncogenes, Signal Transduction and Clinical Applications. Ed. J.E. Kudlow, D.H. MacLennon, A. Bernstein, and A. Gotlieb, pp. 195-211, 1988.
23. Goldsmith, M.A. and Weiss, A.: Generation and analysis of a T lymphocyte somatic mutant for studying molecular aspects of signal transduction by the antigen receptor. Ann. N.Y. Acad. Sci., pp 91-103, 1988.
24. Goldsmith, M.A., Bockenstedt, L.K., Dazin, P. and Weiss, A.: Use of somatic cell mutants to study the signal transduction function of the T cell antigen receptor. Second International Conference of Lymphocyte Activation and Immune Regulation. Plenum, N.Y. pp. 195-211, 1988.
25. Imboden, J.B. and Weiss, A.: The initiation of human T lymphocyte activation. Progress in Allergy. 42:246-279, 1988.
26. Weiss, A.: T Lymphocyte Activation. Fundamental Immunology. Second Edition. Ed. W.E. Paul. Raven Press, New York. pp. 359-384, 1989.
27. Weiss, A. Fraser, J.D., Desai, D.M. and Goldsmith, M.A.: Signal transduction by the T cell antigen receptor. In Progress in Immunology VII, Proceedings of the 7th International Congress of Immunology, F. Melchers, Ed., Berlin, pp 687-692, 1989.
28. Krensky, A.M., Weiss, A., Crabtree, G., Davis, M.M. and Parham, P.: T-lymphocyte-antigen interactions in transplant rejection. N. Engl. J. Med. 322:510-517, 1990.
29. Samelson, L.E. and Weiss, A.: Discussion summary: T cell activation and inactivation. In Immunogenicity, Ed. Charles A. Janeway, Jr., Jonathan Sprent and Eli Sercarz. Alan R. Liss, Inc., New York, pp. 141-146, 1990.
30. Weiss, A.: Structure and function of the T cell antigen receptor. J. Clin. Invest. 86:1015-1022, 1990.
26 Arthur Weiss, M.D., Ph.D.
31. Weiss, A., Desai, D., Graber, M., Picus, J. and Koretzky, G.: The regulation of T cell antigen receptor signal transduction function. Transplant. Proc. 23(1):32-33, 1991.
32. Weiss, A.: Molecular and genetic insights into T cell antigen receptor structure and function. Ann. Rev. Genetics, 25:487-510, 1991.
33. Weiss, A., Irving, B.A., Tan, L. and Koretzky, G.A.: Signal transduction by the T cell antigen receptor. Seminars in Immunology 3:313-324, 1991.
34. Koretzky, G.A., Goldsmith, M.A., Graber, M., Picus, J. and Weiss, A.: Somatic cell genetic approach to understanding T cell antigen receptor signal transduction. Genetic Approaches - Advances in Regulation of Cell Growth, Vol 2, Ed. Mond, J., Cambier, J. and Weiss, A. Raven Press, New York, 1991.
35. Chan, A.C., Irving, B.A. and Weiss, A.: New insights into T-cell antigen receptor structure and signal transduction. Current Opinion Immunol., 4:246-251, 1992.
36. Weiss, A., Chan, A.C., Iwashma, M., Straus, D. and Irving, B.A.: Regulation of protein tyrosine kinase activation by the T cell antigen receptor ζ chain. Cold Spring Harbor Symposium on Quantitative Biology. The Cell Surface, Vol. LVII, pp. 107-116, 1992.
37. Iwashima, M., Chan, A.C., Irving, B., Straus, D. and Weiss, A.: Molecular dissection of T-cell antigen receptor signal transduction. In Progress in Immunology VIII, Proceedings of the 8th International Congress of Immunology, J. Gergely et al Ed., Budapest, pp. 205-211, 1992.
38. Weiss, A.: T Lymphocyte Activation. Fundamental Immunology. Third Edition. Ed. W.E. Paul. Raven Press, New York. pp. 467-504, 1993.
39. Weiss, A.: T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases. Cell 73:209-212, 1993.
40. Fraser, J.D., Straus, D. and Weiss, A.: Signal transduction events leading to T-cell lymphokine gene expression. Immunol. Today 14:357-362, 1993.
41. Weiss, A. and Littman, D.R.: Signal transduction by lymphocyte antigen receptors. Cell 76:263-274, 1994.
42. Chan, A.C., Desai, D.M. and Weiss, A. The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Annu. Rev. Immunol. 12:555-592, 1994.
43. Weiss, A., Iwashima, M., Irving, B.A., van Oers, N.S.C., Kadlecek, T.A., Straus, D. and Chan, A.: Molecular and genetic insights into T cell antigen receptor signal transduction. In: Mechanisms of Lymphocyte Activation and Immune Regulation V: Molecular Basis of Signal Transduction. Eds. Sudhir Gupta, William E. Paul, Anthony DeFranco and Roger Perlmutter, Plenum Press, New York, pp. 53- 62, 1994.
44. Howe, L.R. and Weiss, A.: Multiple kinases mediate T-cell-receptor signaling. TIBS 20:59-64, 1995.
45. Weiss, A., Kadlecek, T., Iwashima, M., Chan, A. and van Oers, N.: Molecular and genetic insights into T-cell antigen receptor signaling. Receptor Activation by Antigens, Cytokines, Hormones, and Growth Factors, Eds. David Naor, Pierre De Meyts, Marc Feldmann and Joseph Schlessinger, Ann. N.Y. Acad. Sci. 766:149-156, 1995.
27 Arthur Weiss, M.D., Ph.D.
46. Weiss, A.: Molecular and genetic insights into the role of protein tyrosine kinases in T cell receptor signaling. Clin. Immunol. Immunopathol.76:S158-S162, 1995.
47. van Oers, N.S.C. and Weiss, A.: The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes. Seminars in Immunology 7:227-236, 1995.
48. Weiss, A.: Zapping tandem SH2 domains. Nature 377:17-18, 1995.
49. Qian, D. and Weiss, A.: T cell antigen receptor signal transduction. Curr. Op. Cell. Biol. 9:205-212, 1997.
50. Weiss, A.: Protein tyrosine kinases involved in the initiation of signals by the T cell antigen receptor. In: Progress in Immunodeficiency VI: Proceedings of the VII Meeting of the European Society of Immunodeficiencies, Goteborg, Sweden, Elsevier Science, 1996.
51. Weiss, A., Miller, L.J.: Halting the march of the immune defenses. Science, 280:179, 1998.
52. DeFranco, A.L. and Weiss, A. Lymphocyte activation and effector functions turning lymphocytes on and off. Curr. Op. Immunol., 10:243-244, 1998.
53. Weiss, A. and Schlessinger, J. Switching signals on and off by receptor dimerization. Cell, 94:277-280, 1998.
54. Weiss, A.: T-Lymphocyte Activation. In Fundamental Immunology, Fourth Edition, pp. 441-448, Ed. Wm. E. Paul, Lippincott-Raven: Philadelphia, 1998.
55. Chu, D.H., Morita, C.T. and Weiss, A. The Syk family of protein tyrosine kinases in T-cell activation and development. Immunol. Rev., 165:167-180, 1998.
56. Weiss, A., and DeFranco, A.L.: Signal transduction by T and B lymphocyte antigen receptors. In Primary Immunodeficiency Diseases, A Molecular and Genetic Approach, pp. 66-81, Eds. H.D. Ochs, C.I.E. Smith, and J. Puck, Oxford University Press: New York, 1999.
57. Elder, M. and Weiss, A.: SCID Resulting from mutations in the gene encoding the protein tyrosine kinase ZAP-70. In Primary Immunodeficiency Diseases, A Molecular and Genetic Approach, pp. 146-154, Eds. H.D. Ochs, C.I.E. Smith, and J. Puck, Oxford University Press: New York, 1999.
58. Finco, T.S., Yablonski, D., Lin, J. and Weiss, A.: The adaptor proteins LAT and SLP-76 are required for T-cell activation. Cold Spring Harbor Symposium on Quantitative Biology, Cold Spring Harbor Laboratory Press, 87969-569-2/99, Vol. LXIV: 265-274, 1999.
59. Kane, LP, Lin, J. and Weiss, A.: Signal transduction by the TCR for antigen. Curr. Op. Immunol., 12:242-249, 2000.
60. Roose, J. and Weiss, A.: T cells: getting a GRP on Ras. Nat. Immunol., 1:275-276, 2000.
61. Tomlinson, M., Lin, J. and Weiss, A.: Lymphocytes with a complex: adapter proteins in antigen receptor signaling. Immunol. Today, 21:584-591, 2000.
62. Yablonski, D., and Weiss, A.: Mechanisms of signaling by the hematopoietic-specific adaptor proteins, SLP-76 and LAT and their B cell counterpart, BLNK/SLP-65, Adv. Immunol., 79:93-128, 2001.
28 Arthur Weiss, M.D., Ph.D.
63. Majeti, R., and Weiss, A.: Regulatory mechanisms for receptor protein tyrosine phosphatases. Chem. Rev., 101:2441-2448, 2002.
64. Hermiston, M.L., Xu, Z., Majeti, R, and Weiss, A.: Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases. J. Clin. Invest., 109:9-14, 2002.
65. Kane, L.P., Lin, J., and Weiss, A.: It's all rel-ative: NF-κB and CD28 costimulation of T-cell activation. Trends in Immunol., 2002. 23:413-420, 2002.
66. Hermiston, M., Xu, Z. and Weiss, A. CD45: a critical regulator of signaling thresholds in immune cells. Annu. Rev. Immunol., 21:107-137, 2003.
67. Kane, L.P., and Weiss, A. The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3. Immunol. Rev., 192:7-20, 2003.
68. Weiss, A., Cambier, J.C. Lymphocyte activation. Curr. Op. Immunol., 16:285-287, 2004.
69. Abraham, R., and Weiss, A. Jurkat T cells and development of the T-cell receptor signalling paradigm. Nat. Rev. Immunol., 4:301-8, 2004.
70. Palacios, E. and Weiss, A. Function of the Src-family kinases, Lck and Fyn, in T cell development and activation. Oncogene, 23:7990-8000, 2004.
71. Levin, S.E., and Weiss, A. Twisting tails exposed: The evidence for TCR conformational change. J. Exp. Med., in press.
72. Weiss, A. Discovering the TCR β-chain by subtraction. J. Immunol., 175:2769-2770, 2005.
73. Zikherman, J. and Weiss, A. Alternative splicing of CD45: The tip of the iceberg. Immunity, 29:839-841, 2008.
74. Zikherman, J. and Weiss, A. Antigen receptor signaling in the rheumatic diseases. Arthr. Research & Therapy, 11:202, 2009.
75. Au-Yeung, B.B., Deindl, S., Hsu, L.Y., Palacios, E.H., Levin, S.E., Kuriyan, J., and Weiss, A. The structure, regulation and function of Zap-70. Immunol. Rev. , 228:41-57, 2009.
76. Weiss, A. Kinases and phosphatases of the immune system. Immunol. Rev., 228:5-8, 2009.
77. Chakraboty, A.K., Das, J., Zikherman, J., Yan, M., Govern, C.C., Ho, M, Weiss, A. and Roose, J. Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes. Sci. Signal, 2:pt2. 2009. In press.
78. Weiss, A. AAI Presidential Address: TCR Signal Transduction: Opening the Black Box. J. Immunol., 183:4821-4827. 2009.
79. Weiss, A. The right team at the right time to go for home runs: Tyrosine kinase activation by the TCR. Nature Immunol., 11:101-104, 2009.
80. Wang, H., Kadlecek, T.A., Au-Yeung, B.B., Goodfellow, H.E., Hsu, L.Y., Freedman, T.S., and Weiss, A. Cold Spring Harbor Perspect. Biol., 2:002279
29 Arthur Weiss, M.D., Ph.D.
Books Edited
1. Mond, J.J., Cambier, J.C. and Weiss, A. (Editors): Advances in Regulation of Cell Growth: Regulation of Cell Growth and Activation. Raven Press, New York, 1989.
2. Mond, J.J., Cambier, J.C. and Weiss, A. (Editors): Advances in Regulation of Cell Growth, Volume 2. Cell Activation: Genetic Approaches. Raven Press, New York, 1991.
PATENTS ISSUED
Chimeric Chains for Receptor-Associated Signal Transduction Pathways U.S. Patents # 5,359,046, #6,319,494, # 6,407,221 Screening Assay for the Identification of Novel Immunosuppressives Using Cultured T Cells U.S. Patent #5,474,897
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