Cytokines MONTRÉAL 2008
Translating Science into Health: Cytokines in Cancer, Infl ammation and Infectious Diseases
7th Joint Conference of the International Cytokine Society and the International Society for Interferon and Cytokine Research Photo: Tourisme Montréal Photo: Tourisme
October 12-16, 2008 Fairmont Queen Elizabeth Hotel Montreal Quebec CANADA
Cytokines Montreal 2008 1 PROGRAM From cell separation to molecular analysis
The Gold Standard in Cell Isolation • Separation of functional, cytokine-secreting cells • Virtually any cell type from any species • Superior viability, purity and recovery
Cytokines and Growth Factors • New, broad portfolio: human - mouse - rat • Excellent purity and activity • Optimized for cell culture applications
MACSmolecular Tools for Molecular Analysis • Tools for signal transduction • State of the art microRNA analysis • Comprehensive gene expression profiling
Unless otherwise specifically indicated, Miltenyi Biotec products and services are for research use only and not for therapeutic or diagnostic use.
Miltenyi Biotec Inc. Phone 800 FOR MACS www.miltenyibiotec.com 12740 Earhart Avenue +1 530 888 8871 [email protected] Auburn CA 95602, USA Fax +1 530 888 8925 2 Cytokines Montreal 2008 ContentsWelcome to Montreal ...... 4-5 Sponsors and Exhibitors ...... 6 Conference Venue ...... 11 Scientifi c Information ...... 12 Registration ...... 14 Program at a Glance ...... 15 Conference Floor Plan ...... 16 Invited Speakers ...... 16
Scientifi c Program Sunday, October 12 ...... 17 Monday, October 13 ...... 18 Tuesday, October 14 ...... 28 Wednesday, October 15 ...... 36 Thursday, October 16 ...... 45
General Information ...... 47 Social Program ...... 48 A Walking Tour of Downtown ...... 50
Canadian Organizing Committee
John Hiscott, McGill University Karen Mossman, McMaster University Marc Servant, Université de Montréal Michele Barry, University of Alberta Eleanor Fish, University of Toronto John Schrader, University of British Columbia
International Organizing Committee
Christine Czarniecki (USA) Alberto Mantovani (Italy) Thomas Decker (Austria) Eliane Meurs (France) Scott K. Durum (USA) Luke A.J. O’Neill (Ireland) Takashi Fujita (Japan) Nancy Reich (USA) Adolfo Garcia-Sastre (USA) Christian Schindler (USA) Otto Haller (Germany) Josef Schwarzmeier (Italy) Raymond Kaempfer (Israel) Michael Tovey (France) George Kukolj (Canada) Carl Ware (USA) Santo Landolfo (Italy) Bryan Williams (Australia) Allan Lau (China) Howard Young (USA) Warren Leonard (USA)
Cytokines Montreal 2008 3 Bienvenue’est avec grand plaisir à que jeMontréal vous souhaite la bienvenue à cette 7e rencontre conjointe de la Société internationale pour la recherche sur Cl’interféron et les cytokines et de la Société internationale des cytokines : Cytokines 2008. Notre conférence a mobilisé l’expertise biomédicale et les efforts de ces deux sociétés afi n de vous présenter une mise à jour complète des hypothèses les plus récentes quant au rôle élémentaire et clinique des cytokines dans le cancer, l’infl ammation et les maladies infectieuses. Le thème général de cette conférence, l’utilisation des connaissances scientifi ques pour améliorer la santé, a été choisi afi n de mettre l’emphase sur l’intégration des recherches fondamentales, précliniques, pharmaceutiques et cliniques dans les domaines du cancer, de la modulation immunitaire, de l’infl ammation et des maladies infectieuses. Les sujets abordés comprendront l’identifi cation des pathogènes et leur signalisation pour le déclenchement d’une réaction immunitaire, l’infl ammation et le cancer, la biologie et les fonctions des cellules immunitaires et des cytokines, et les stratégies utilisées par les pathogènes pour échapper à la réaction immunitaire de l’hôte. Une part importante de la conférence sera aussi dédiée aux traitements agissant sur les cytokines dans le cancer et d’autres troubles de santé, ainsi que sur les thérapies émergentes ayant pour cible les cytokines dans les maladies autoimmunes et infl ammatoires. Des scientifi ques chevronnés, des jeunes chercheurs, des médecins, des boursiers postdoctoraux, des étudiants aux cycles supérieurs et des représentants des compagnies pharmaceutiques profi teront amplement de ce lieu de réunion favorisant les échanges. Nous croyons que cette conférence—qui a lieu dans la belle ville cosmopolite de Montréal lors de l’époustoufl ante fête des couleurs de l’automne—mettra en évidence les meilleures recherches actuelles sur les cytokines.
4 Cytokines Montreal 2008 Welcomet is my pleasure to welcome to youMontreal to the 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the IInternational Cytokine Society: Cytokines 2008. Our Conference has harnessed the biomedical expertise and energies of both societies to provide a comprehensive update of recent insights into basic and clinical aspects of Cytokines in Cancer, Infl ammation and Infectious Diseases. The overall theme of this Conference is Translating Science into Health, and is chosen to emphasize the integration of basic, pre-clinical, pharmaceutical and clinical research in the areas of cancer, immune modulation, infl ammation and infectious diseases. Topics to be covered include: pathogen recognition and signaling to the immune response, infl ammation and cancer, the biology and functions of immune cells and cytokines, and pathogen strategies to evade the host immune response. Part of the conference is also devoted to cytokine-based therapies in malignancy and other disorders, as well as emerging therapies targeting cytokines in autoimmune and infl ammatory diseases. Senior scientists, young investigators, physicians, postdoctoral fellows, graduate students and representatives of the pharmaceutical industry will all benefi t from the interactions available at this venue. We believe that this Conference— set in the beautiful cosmopolitan city of Montreal during the stunning fall display of colors—will refl ect the best of current cytokine research.
Cytokines Montreal 2008 5 THANK YOU TO
Platinum
Gold
Silver
Bronze
6 Cytokines Montreal 2008 OUR SPONSORS
Sponsors
Supporter
Other Amounts
Cytokines Montreal 2008 7 Exhibitors
Assay Designs, Inc. BioLegend, Inc. Emily Riesterer Claudia Arellano, Marketing Coordinator Marketing Communications Supervisor 11080 Roselle Street 5777 Hines Dr. San Diego, CA 92121 Ann Arbor, MI 48108 Tel: 858-455-9588 Tel: 800-833-8651 or 734-668-6113 Fax: 858-455-9587 Fax: 734-668-2793 Website: http://www.biolegend.com/ Website: www.assaydesigns.com BOOTH #3 BOOTH #1 Representatives: Gene (Jeng Guang) Lay, Benjamin (Brad) Kraft, Representative: Tonya Goodman Shaoquan Ji
Assay Designs manufactures immunassays, antibodies, and BioLegend, Inc. manufactures reagents for immunology and proteins for the academic and pharmaceutical research markets, cell biology research. Selection of fl uorochrome conjugated including custom immunoassay development and custom bulk antibodies, including Pacifi c Blue, Alexa and tandem dyes. reagent production and conjugation. Novel antibodies: Treg (FOXP3, TSLP-R, GITR). Innate Immunity (TLRs, NTB-A, CCR7), Cytokines.Chemokines (IL-17, 1L-23,TSLP), BD Biosciences Stem Cells (Nanog, FZD9, SOX-2, REX-1, FOXD3, FOXO3a); for FACS, ELISA, ELISPOT, IHC, IP, IF and WB. Andrea Brueschke, Product Manager 2280 Argentia Road Mississauga, ON L5N 6H8 Cedarlane Laboratories Ltd. Tel: 905-542-6285 Naomi Wessel-Bonnar, Marketing Coordinator Fax: 905-542-9391 4410 Paletta Court Website: http://www.bdbiosciences.com/ Burlington, ON L7L 5R2 Tel: 289-288-0001, Toll Free: 1-800-268-5058 BOOTH #12 Fax: 289-288-0020, Toll Free: 1-800-638-5099 Representatives: Alex Brunet, Benoit Lachapelle Website: http://www.cedarlanelabs.com/
BD Biosciences (Becton, Dickinson and Company) is a medical BOOTH #9 & 10 technology company that serves healthcare institutions, clinical Representatives: Kyle Pahapill and Kevin Tutenberg laboratories, life science researchers, and industry. BD manu- factures and sells a broad range of medical supplies, devices, Cederlane specializes in providing high quality reagents to laboratory equipment and diagnostic products. BD Biosciences, the life science community. We are an ISO 9001: 2000 and ISO a segment of BD, provides a comprehensive portfolio of con- 13485:2003 registered company. Acting as both a manufacturer sumables, reagents, and instruments, including antibodies, and a distributor we offer monoclonal & polyclonal antibod- tissue culture products, and fl ow cytometers, to support the ies, molecular and cell biology reagents, micro-arrays, custom life sciences industry. services, temperature sensitive shipping supplies & more.
Bender MedSystems GmbH eBioscience Ms Birgit Osterhoff, Ph.D. Rachel Yeager, Marketing Communications Specialist International Distributor Coach Campus Vienna Biocenter 2 10255 Science Center Dr. Vienna, Austria 1030 San Diego, CA 92121 Tel: +43-01-796-4040-111 Tel: 888-999-1371 Fax: +43-01-796-4040-400 Fax: 858-642-2080 Website: http://www.bendermedsystems.com/ Website: http://www.eBioscience.com/
BOOTH #5 BOOTH #11 Representatives: Ms Birgit Osterhoff, Ph.D. Representatives: Edwin Chau, Peggy Just, David Sehy, Mark Konrad Our portfolio includes Elisa Kits, Antibodies and Proteins for re- search in immunology and cellular biology, adhesion, cytokines, eBioscience provides innovative high quality reagents to apoptosis, tumor biology. researchers worldwide that empower the process of scientifi c discovery in the areas of cellular immunity and oncology. Our Bender MedSystems FlowCytomix bead-based assays follow the extensive portfolio of leading edge cell analysis products and same principle as a sandwich immunoassay. The FlowCytomix technologies focused on fl ow cytometry and immunodetection multiplexing technology enables the simultaneous detection of position our customers to be at the forefront of science. multiple analytes from only 25 µl of sample! FlowCytomix kits can be used on most commercially available fl ow cytometers. GSK – GlaxoSmithKline Biologicals Chemokines are inter-cellular messengers in infl ammatory reac- tions and immunity, but also play a role in many pathological North America processes. Daniel Larocque, Ph.D., Scientist 525 Blvd. Cartier West Laval, Quebec H7V 3S8 Tel: 450-978-8293 Fax: 450-978-6343 Website: http://www.gsk-bio.com/
BOOTH #13 Representative: Daniel Larocque, Steven Tran
8 Cytokines Montreal 2008 Exhibitors
HumanZyme Inc. Meso Scale Discovery, A Division of Frederic Rhoads, Vice-President Sales and Marketing Meso Scale Diagnostics, LLC. 2201 W. Campbell Pk. Dr. 24 Debbie O’Connell, Marketing Specialist/Event Planner Chicago, IL 60612 9238 Gaither Road Tel: 312-738-0127 Gaithersburg, Maryland 20877 Fax: 312-276-8128 Tel: 240-831-2522 Website: http://www.humanzyme.com/ Fax: 240-632-2219 Website: http://www.mesoscale.com/ BOOTH #21 Representative: Frederic Rhoads BOOTH #18 Representatives: Carter Cliff, Brooke Murphy Human cell expressed cytokines and growth factors, non- human cytokines, human kinases, coagulation proteins. Meso Scale Discovery (MSD®) specializes in detection of proteins in biological samples. Through the combination of patterned arrays Invitrogen and electrochemiluminescence, the MSD platform increases Dana Bassett, Marketing Project Coordinator throughput via multiplex capability, offers sensitive assays with 5791 Van Allen Way wide dynamic ranges. Carlsbad, CA 92008 Tel: 541-335-0346 Millipore Corporation Fax: 541-344-6504 Natasha Sotomayor, Exhibit Specialist Website: http://www.invitrogen.com/ 290 Concord Road Billerica, MA 01821 BOOTH #14 Tel: 800-645-5476 Representatives: Jeff Croissant, Thao Sebata, Stephanie Graber Fax: 800-645-5439 Website: http://www.millipore.com/ Invitrogen Corporation provides products and services that support academic and government research institutions and BOOTH #17 pharmaceutical and biotech companies worldwide in their ef- Representatives: Janna Pull, Todd Hendrich forts to improve the human condition. Invitrogen is your source for Molecular Probes, BioSource, Caltag, and Zymed cellular Millipore offers the largest portfolio of biomarker immunoassays pathway exploration tools, including ELISAs, Luminex® assays, including RIAs, ELISAs, Multiplex Assays using the Luminex xMAP kinase activity assays, protein arrays, antibodies and recom- technology (MILLIPLEXTM) for the better understanding of the binant proteins. Our products help researchers improve their mechanisms of diseases such as diabetes, obesity, cancer, cardio- understanding of the role of both extracellular proteins and vascular disease, infl ammation and more, providing consistent, intracellular proteins and their function in the disease process. high-quality products for drug discovery and development. The Invitrogen is committed to providing the most innovative path- expertise of Upstate Chemicon and Linco are now a part of Millipore. way solutions along with personalized customer support. Miltenyi Biotec, Inc. Mabtech AB Kent Jordan ([email protected]) Alexandre Antoni, International Sales Manager Product Marketing Specialist Augustendalsvägen 19 12740 Earhart Avenue Nacka Strand, Sweden 131 28 Auburn, CA 95602 Tel: 46(0)8-556 798 23, 46(0)8-716 27 00 Tel: 530-887-5321 (direct) Fax: 46(0)8-716 27 01 Fax: 1-800-367-6227 (toll free) Website: http://www.mabtech.com/ Website: http://www.miltenyibiotec.com/
BOOTH #2 BOOTH #24 Representatives: Alexandre Antoni, Sten Braesch-Anderson Representative: Kirt Braun
Mabtech AB is a privately owned Swedish biotech company MACS® Column Technology – The gold standard in magnetic cell founded in 1986. Emerging from the Department of Immunol- separation ogy at Stockholm University, Mabtech has become a world MACS Technology is based on MACS MicroBeads, MACS Columns leader in ELISpot and T-cell measurements. and Separators. Gentle and fast separation of cells labeled with mini- mal amounts of MACS MicroBeads. Column technology allows for Medicorp Inc. convenient sample processing and washing under sterile conditions. Normand Pepin Excellent purity and recovery of viable and functionally active cells. General Manager Please visit our web site www.miltenyibiotec.com to fi nd out more 5800 Royalmount about more than 250 MACS Cell Separation Reagents. ® Montreal, Qc H4P 1K5 MACS Column Technology – For manual and automated magnetic Tel: 514-733-1900, Toll free:1-877-733-1900 cell separation. Fax: 514-733-1212 Website: http://www.medicorp.com PBL Interferon Source Jaleel Shujath BOOTH #20 131 Ethel Road W, Suite #6 Representatives: Louise Blanchette, Genèvieve Bourque Piscataway, NJ 08854 Tel: 732-777-9123 MEDICORP is one of Canada’s largest, independent distributors Fax: 732-777-9141 of immunodiagnostic and research products. MEDICORP Website: http://www.interferonsource.com/ distributes an expanding line of products in immunology, endocrinology, cell biology, molecular biology and labware BOOTH #7 products. Representative: Jaleel Shujath
World’s leading manufacturer and distributor of interferon products.
Cytokines Montreal 2008 9 Exhibitors
PeproTech, Inc. Roche Dawn Huxley, Sales Manager Hélène Ouellett, Marketing Coordinator, Freezer Program P.O. Box 275, 5 Crescent Avenue Applied Science & Molecular Diagnostics Rocky Hill, NJ 08553 Laboratory, Hospital and Research Systems Tel: 609-497-0253 x123 201 Boul Armand-Frappier Fax: 609-497-0321 Laval, QC H7V 4A2 Canada Website: http://www.peprotech.com/ Tel: 450-686-5486 Fax: 450-686-7009 BOOTH #19 Website: http://www.roche-applied-science.com Representatives: Jason Palmucci, McDuffy Barrow BOOTH #23 PeproTech manufactures an extensive line of Recombinant Human, Representatives: Julies Desnoyers, Julie Fortier Murine and Rat Cytokines as well as a complementary line of Mono- clonal Antibodies, Affi nity Purifi ed Polyclonal Antibodies, Affi nity Pu- Rules Based Medicine, Inc. rifi ed Biotinylated Polyclonal Antibodies and Elisa Development Kits. Rob Bencher, Director 3300 Duval Road Pfi zer Canada Inc. Austin, TX 78759 Nathalie Savoie, Administrative Coordinator, Medical division Tel: 215-806-1747 17300 Trans Canada Highway Fax: 215-733-9225 Kirkland, Quebec H9J 2M5 Website: http://www.rulesbasedmedicine.com/ Tel: 514-426-7544 Fax: 514-693-4500 BOOTH #22 Website: http://www.pfi zer.ca Representative: Rob Bencher
BOOTH #8 Rules Based Medicine is a service laboratory which provides multi- Representatives: Sophia Calmels, Guillaume Feugere, Karima analyte profi le (MAP) testing. MAPS provide a comprehensive Fazal-Karim, Luc Levesque, Christine Mormont, evaluation of protein response to disease, drugs, or the enviro- Bertrand Roy nment. All studies are performed under GLP guidelines and are typically performed within a period of 2 weeks. Please contact Pfi zer Canada Inc. is the Canadian operation of Pfi zer Inc, the world’s [email protected] for additional information. leading pharmaceutical company and is located in Kirkland, Quebec. Pfi zer discovers, develops, manufactures and markets prescription STEMCELL Technologies Inc. medicines for humans and animals. Pfi zer Inc invests more than Julie Robinson, Conference Coordinator US$7 billion annually in R&D to discover and develop innovative life- 400-570 West 7th Ave. saving and life-enhancing medicines in a wide range of therapeutic Vancouver, B.C. V5Z 1B3 areas. Global headquarters are located in New York City, where the Tel: 604-675-7715 company was founded in 1849. Fax: 1-800-567-2899 Website: http:// www.stemcell.com R&D Systems Tracey Husted, Marketing BOOTH #16 614 McKinley Place NE Representatives: Benoit Guilbault, Paul Wolf Minneapolis, MN 55413 Tel: 612-379-2956 About STEMCELL Technologies – STEMCELL Technologies, a leader Fax: 612-379-6580 in specialty cell culture media, cell separation products and ancillary Website: http://www.rndsystems.com/ reagents for life science research, is a privately-owned biotechnol- ogy company based in Vancouver, Canada. Driven by science, BOOTH #4 STEMCELL delivers over 800 products to more than 60 countries Representative: Vassilios Kalabokis worldwide. To learn more about how STEMCELL helps to make research work, visit R&D Systems serves the basic research, clinical research, and diag- nostic markets with products for cell biological research. We provide Wisent, Inc. purifi ed proteins; antibodies; kits and reagents for ELISAs, multiplex Michel Rotaru, Sales Representative assays and assays services. P.O. Box 131, St-Bruno Montréal, Québec J3V 4P8 Randox Laboratories, Ltd. Tel: 450-446-2660 [email protected] Fax: 450-446-7038 55 Diamond Road Website: http://www.wisent.ca/ Crumlin Co. Antrim BOOTH #15 United Kingdom BT29 4QY Representative: Michel Rotaru Tel: +44 (0) 28-9442-2413 Fax: +44 (0) 28-9445-2912 Website: http://www.randox.com/
BOOTH #6 Representatives: Craig Matson, Jonathon Porter
Randox is an international diagnostics company, headquartered in the UK, which develops, manufactures and markets clinical diag- nostics worldwide. Randox specialise in biochip arrays and Biochip Array Technology analysers. The range of biochip arrays includes cytokine biochips for simultaneous detection of up to 12 cytokines in a single sample.
10 Cytokines Montreal 2008 Conference Venue Cytokines 2008 is being held at the Fairmont Queen Elizabeth Hotel, centrally located adjacent to Place Ville Marie in the downtown area of Montreal.
Fairmont Queen Elizabeth Hotel 900, René Lévesque Ouest Montréal, Québe H3B 4A5 Tel: 514-861-3511 Fax: 514-954-2256
http://www.fairmont.com
For other useful information about Montreal, please visit: www.tourisme-montreal.org
Airport: Pierre Elliott Trudeau International, 22 km west of downtown, now serves all domestic, U.S. and inter- national passenger fl ights.
A taxi ride from anywhere in town to Trudeau Airport costs a fl at rate of $38-$40 CDN. Important Addresses & Information Aerobus shuttle bus service runs from the downtown bus terminal (514-842-2281) with several stops before CONFERENCE SECRETARIAT taking the highway. Fares are lower than taxis: Gabriella Di Pancrazio $12-$15 CDN to or from Trudeau airport. Lady Davis Institute for Medical Research Sir Mortimer B. Davis – Jewish General Hospital It is also possible to get to Trudeau Airport by taking 3755 chemin de la Côte Ste-Catherine regular city buses: the 211 and the 204 will get you Montréal, Québec H3T 1E2 there from downtown, but the 211 could be tricky Tel: 514-340-8308 Fax: 514-340-7502 with a lot of baggage at busy times of day. E-mail: [email protected]
Buses: Montreal has bus connections to other cities within SCIENTIFIC SECRETARIAT Quebec, to the rest of Canada and to the United Prof. Dr. John Hiscott States. Intercity bus travel does not carry the same Lady Davis Institute for Medical Research stigma as in the U.S. and the buses to Quebec City Sir Mortimer B. Davis – Jewish General Hospital and Toronto, for example, are clean and pleasant. McGill University The main bus terminus is the Station Centrale at 3755 chemin de la Côte Ste-Catherine the corner of Berri and de Maisonneuve, tel. 514- Montréal, Québec H3T 1E2 842-2281. E-mail: [email protected] Trains: Montreal is on the Via Rail Windsor-Quebec corridor. EXHIBITION MANAGEMENT You can reserve tickets on their website or get them from your travel agent. Clarkson Conway – Exhibits AVW-TELAV – Audiovisual Amtrak runs the Adirondack from New York to Christine Lalonde – Graphic Design Montreal daily. Their website also offers reservations. Mélanie Philion – Hotel Liason
There are two major downtown train stations, Central Station (Gare Centrale) and Windsor Station (recently CONGRESS HOME PAGE renamed L’Allier Station). Both are connected to the http://www.cytokines2008.org Bonaventure Metro station and are thus connected to the underground city. Windsor/L’Allier is only used for commuter trains now.
Cytokines Montreal 2008 11 Scientifi c Information Overview of the Sessions All Plenary sessions (PL1 – PL4) will take place in the Grand Salon from 8:30 – 12:30 (Mon- Thurs); two parallel Symposia (SY1-SY6) will take place each day (Mon-Wed) from 16:30 – 18:00 and four concurrent Workshops (Mon-Wed) will take place each day from 14:00 – 16:00 (WO1-WO12). Four concurrent Poster sessions (PP1-PP12) will also take place each day from 18:00 – 19:30, with selected Poster Discussions (PD) taking place each evening from 18:15 – 19:30. Also, a Late Breaking (LB) session has been scheduled for Thursday Oct. 16 at 14:00-16:00. The abbreviations above (PL1, SY2, WO3 and PP4 etc) refer to the specifi c sessions; the number following the session designation denotes the Abstract number in the Conference Abstract issue of CYTOKINE.
Presentation Instructions for Workshops and Posters On the following pages are the titles and authors (including Abstract numbers and session type) for the Plenary, Symposia, Workshop and Poster Sessions. Please note that WO refers to a Special Topics Workshop (also referred to as an Oral Presentation), PP refers to a Poster Presentation, and PD refers to a Poster Discussion Session. The number following the ab- breviation indicates the session number, followed by the Abstract number in the Conference issue of CYTOKINE.
Workshop Sessions: Listed below are the Workshop Sessions including day and time of presentation, abstract numbers in each session and session chairs. The time allotted for oral presentations is 15 minutes (12 minutes for talk and 3 minutes for discussion). Please be certain to time your presentation to conform to these guidelines. Both PC and Mac computers will be available to load your presentation. Chairpersons are asked to be in the session room at least 15 minutes prior to the beginning of the session and should make every effort to maintain the time schedule.
Speaker Ready Room: Saguenay located on the Convention Floor Level of the Fairmont Queen Elizabeth Hotel is the designated “Speaker Ready Room”. It will be open throughout the meeting so that you may prepare or preview your material prior to your oral presentation. It is recommended that you bring your presentation on a USB fl ash drive or CD. The technician in your session room will be available to pre-load your talk onto a central computer (PC and Mac available) to avoid delays between presentations. You will need to be in the session room approximately 30 minutes prior to the session, so that loading of talks can be completed prior to the fi rst presentation.
Poster Sessions: Posters are divided into three sessions – one session per day (Sessions listed below). Authors are requested to put up their posters during the morning of the specifi c poster session (or the night before, as soon as the boards are ready). The posters will be available for “brows- ing” throughout the day (08:30 – 19:30). Poster Sessions (and Poster Discussion Sessions) with Wine and Cheese will be from Monday – Wednesday between 18:00 – 19:30 each day. Presenters are requested to stand by their posters during this designated poster session time on their scheduled day to answer questions. Poster sessions will be held in Hochelaga 2-6. After the session, please remove your poster by latest 20:00 as posters will be changed every day. • Posters can be fi xed with push pins provided by the Conference Management which will be available in the Poster Session Rooms and at the Registration Desk. Should you wish to use Male-velcro, you will need to bring your own. • Please note that only posters 4 feet high (from top to bottom) and 8 feet wide (from side to side) can be presented.
12 Cytokines Montreal 2008 Poster Discussion Sessions: Each evening during the Poster session, 4 to 6 posters will be highlighted for a short discus- sion session from 18:15 – 19:30. Presenters are invited to prepare a 10 minute slide presenta- tion of the results of their poster. Please leave time for questions. Selected posters will be grouped together in a semi-circle in Hochelaga 2 and delegates are invited to attend this short informative focus session. Please note that because of the large number of posters in PP2, three topics will be presented on Monday, October 13, fi ve topics will be presented on Tuesday, October 14, and four topics will be presented on Wednesday, October 15, as indicated in the table below.
DATE TOPICS
Monday, October 13 PP1: Signal Transduction I PP2: Cytokines in the Pathogenesis of Infl ammatory Disease PP3: Cytokines and Chemokines: Mechanisms of Action
Tuesday, October 14 PP4: Immune Cell Activation and Function PP5: Gene Regulation: Transcriptional and Post-transcriptional Mechanisms PP6: Control of Cell Growth and Death in Cancer and Hematopoiesis PP7: Structure and Function of Cytokines and their Receptors PP8: Pathogen Evasion of the Host Cytokine Response
Wednesday, October 15 PP9: Cytokines in the Development of Innate and Adaptive Immunity PP10: Induction of Cytokines and Interferons PP11: Cytokines in Preclinical Models of Cancer and Infectious Disease PP12: Signal Transduction II
Speaker Ready Room Will be open during the registration hours. It is important that all speakers check their presentations before their sessions in the Speaker Ready Room, the Saguenay located on the Convention Floor. This room will be available as of Sunday, October 12, 2008 – 12:00. If you are scheduled to speak in the morning we ask you to check your presentation the afternoon before. For afternoon presentation please check at least two hours prior to the beginning of your session.
Cytokines Montreal 2008 13 MEZZANINE LEVEL and ALCOVE LEVEL
RegistrationThe registration desk will be open:
Sunday, October 12, 2008 13:30 – 20:00
Monday, October 13, 2008 through Wednesday, October 15, 2008 08:00 – 18:00
Thursday, October 16, 2008 08:00 – 12:00
Registration Fees Early Advance At The Meeting
Academic/Government (member) $500 $600 $650 Academic/Government (non member) $600 $700 $750 Industry $700 $800 $900 Students/Residents/Postdocs $250 * $300 $350 Accompanying Guests $200 $250 $300
*Early registration for 4 or more students from the same laboratory will receive one complimentary registration.
The registration fee for participants includes: • Admission to the scientifi c sessions • Admission to the commercial exhibition • Conference documents and the Abstract book • Opening Ceremony and Welcome Reception at the Fairmont Queen Elizabeth Hotel, Hochelaga 1-6, Sunday, October 12, 2008 • Notre Dame Basilica de Montreal Monday, October 13, 2008 (since space is limited, only the fi rst 320 registrants can be accepted) • An Evening at the Montreal Museum of Fine Arts Tuesday, October 14, 2008 • Gala Dinner in the heritage Windson Station Wednesday, October 15, 2008
The registration fee for accompanying persons includes the following: • Opening Ceremony and Welcome Reception at the Fairmont Queen Elizabeth Hotel, Hochelaga 1-6, Sunday, October 12, 2008 • Admission to the commercial exhibition • Notre Dame Basilica de Montreal Monday, October 13, 2008 (since space is limited, only the fi rst 320 registrants can be accepted) • An Evening at the Montreal Museum of Fine Arts Tuesday, October 14, 2008 • Gala Dinner in the heritage Windson Station Wednesday, October 15, 2008
14 Cytokines Montreal 2008 Program at a Glance (Foyer) Plenary Session 4 Cytokine-Based Therapeutics
Coffee Break Coffee (Foyer) (Foyer) Windsor Station ISICR General Membership Coffee Break Coffee Coffee Break
(Foyer) (Foyer) Coffee Break Coffee Break Coffee (Foyer) (Foyer) ISICR / ICS Joint Board (Continued) (Continued) (Continued) (Continued) (On your own) (On your own) (On your own) PBL Tutorial PBL Tutorial JICR Luncheon Symposium 1 & 2 Symposium 3 & 4 Symposium 5 & 6 Plenary Session 1 Plenary Session 2 Plenary Session 3 Keynote Lecture II and Adaptive Immunity Poster Discussion 1 Poster Discussion 2 Poster Discussion 3 1) Interferon Stimulated Genes 3) microRNAs Signaling 5) Lymphocyte Pattern Recognition Receptors ammation and Cancer Infl Cytokines and Emerging Taniguchi Tada Dr. (Hochelaga 2 to 6 & Marquette) (Hochelaga 2 to 6 & Marquette) (Hochelaga 2 to 6) Special Topics Workshops Workshops Special Topics Workshops Special Topics Workshops Special Topics Late Breaking Session
(1-4) (5-8) (9-12) (11:00 – 17:30) (14:00 – 17:30) (20:00 – 20:30) Dr. Nahum Sonenberg Dr. Keynote Lecture I PP1 to PP3 PP4 to PP8 PP9 to PP12 Opening Ceremony Poster Presentations Poster Presentations Poster Presentations Welcome Reception Welcome Notre Dame Basilica Evening at the Museum Dreamscape Gala ICS Council Meeting ISICR Committee Meetings Plenary Session 1 Plenary Session 2 Plenary Session 3 Plenary Session 4 Break Coffee Lunch Break Lunch Break Lunch Break
Coffee Break 12:30 – 14:00 (18:00 – 20:00) 2) TNF Superfamily 4) Th 17 / IL17 6) Regulatory T Cells and Signaling to Innate Infectious Pathogens (08 :30 –09 :00)
Time 07:30 – 08:30 08:30 – 10:30 October 12, 2008 Sunday October 13, 2008 10:30 – 11:00 11:00 – 12:30 October 14, 2008 Monday October 15, 2008 Tuesday October 16, 2008 14:00 – 16:00 16:00 – 16:30 Wednesday 16:30 – 18:00 18:00 – 20:30 Thursday 20:00 – 00:30 (Hochelaga 1 to 6) (20:30 – 22:30) Light” & “And Then There Was Organ Recital by Pierre Grandmaison (19:30 – 22:00) (20:00 – 21:30) (20:00 – 00:30)
Awards Presentations Awards Meeting (Richelieu) Meeting
with Buffet Dinner de Montreal of Fine Arts
Maurice) (Saint (Jolliet) (Chaudiere) Meeting HumanZyme Tutorial (Saint Maurice) ICS General Membership Meeting (Marquette)
Cytokines Montreal 2008 15 Fairmont The Queen Elizabeth Hotel
SAINT LAURENT
GATNEAU
BERMISE
PERIBONCA
RICHELIEU
HARRICANA
CHAUDIERE LE GRAND SALON MARQUETTE JOLLIET DULUTH MACKENZIE
MATAPEDIA
SAINT CHARLES
YAMASKA 23 22 SAINT MAURICE 24 21 25
17 18 19 20 SAGUENAY 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Hochelaga Hochelaga Hochelaga Hochelaga Hochelaga Hochelaga 1 2 3 4 5 6
Speakers
BAECHER-ALLAN Clare, Harvard University (USA) LEONARD Warren, National Institutes of Health (USA) BARBER Glen, University of Miami (USA) LI Xiaoxia, Lerner Research Institute, Cleveland Clinic (USA) BLATT Lawrence M., Alios BioPharma, South San Francisco (USA) LIU Yong-Jun, MD Anderson Houston (USA) BOWIE Andrew, Trinity College Dublin (Ireland) MAK Tak, University Health Network, University of Toronto (Canada) BROWNING Jeff, Biogen Idec (USA) MANTOVANI Alberto, Instituto Clinico Humanitas (Italy) CHENG Genhong, University of California, Los Angeles (USA) McFADDEN Grant, University of Florida (USA) COYLE Anthony, MedImmune Inc. (USA) MEDZHITOV Ruslan, Yale University School of Medicine (USA) CROW Mary K., Weill Medical College (USA) MIKKOLA Marja, University of Helsinki (Finland) DAVID Michael, University of California, San Diego (USA) O’NEILL Luke A.J., Trinity College Dublin (Ireland) DONG Chen, MD Anderson, Houston TX (USA) O’SHEA John, National Institutes of Health (USA) DECKER Thomas, University of Vienna (Austria) OZATO Keiko, National Institutes of Health (USA) DINARELLO Charles, University of Colorado (USA) PHILPOTT Dana, University of Toronto (Canada) FELDMANN Heinz, Rocky Mountain Labs (USA) REIS E SOUSA Caetano, London Research Institute, (UK) FELDMANN Marc, Kennedy Institute of Rheumatology (UK) SCHINDLER Christian, Columbia University (USA) FISH Eleanor, University Health Network, University of Toronto (Canada) SEN Ganes C., Lerner Research Institute, Cleveland Clinic (USA) FOX Paul, Lerner Research Institute, Cleveland Clinic (USA) SHEVACH Ethan, National Institutes of Health (USA) FUJITA Takashi, Kyoto University (Japan) SILVERMAN Robert H., Lerner Research Institute, Cleveland Clinic (USA) GAFFEN Sarah, SUNY Buffalo (USA) SONENBERG Nahum, McGill University (Canada) GALE Michael, University of Washington (USA) TANIGUCHI Tadatsugu, University of Tokyo (Japan) GARCIA-SASTRE Adolfo, Mount Sinai School of Medicine (USA) TING Jenny P-Y., University of North Carolina at Chapel Hill (USA) GOODALL Greg, Hanson Institute, Adelaide (Australia) TRINCHIERI Giorgio, National Cancer Institute-Frederick (USA) HORVATH Curt, Northwestern University (USA) TSCHOPP Jurg, University of Lausanne (Switzerland) HSIEH Chyi-Song, Washington University, St. Louis (USA) VAN DEN BERG Wim, University of Nijmegen Medical Center (Netherlands) JOVE Richard, Beckman Research Institute, City of Hope (USA) WARE Carl, LaJolla Institute of Allergy and Immunology (USA) KISHIMOTO Tadamitsu, Osaka University (Japan) WILLIAMS Bryan, Monash Institute (Australia) KOLLIAS George, Alexander Fleming Institute (Greece) YOUNG Howard A., National Cancer Institute-Frederick (USA) LAFAILLE Juan, New York University (USA)
16 Cytokines Montreal 2008 Sunday, October 12, 2008
11:00 – 12:30 ISICR Publications Committee MATAPÉDIA 12:00 – 13:30 ISICR Membership Committee CHAUDIÈRE 12:30 – 14:30 ICS & ISICR Meetings Committees SAINT MAURICE 12:45 – 14:15 ISICR Finance Committee MATAPÉDIA 13:45 – 15:15 ISICR Awards Committee CHAUDIÈRE 15:00 – 16:30 ISICR Nomenclature Committee SAINT MAURICE 15:00 – 17:00 ISICR Standards Committee MATAPÉDIA 15:30 – 17:30 ISICR Board of Directors CHAUDIÈRE
14:00 – 17:30 ICS Council Meeting HARRICANA
OPENING SESSION LE GRAND SALON 18:00 OPENING REMARKS - WELCOME John Hiscott (Chair, Scientifi c Organizing Committee) Eleanor Fish (President, International Society for Interferon and Cytokine Research) Carl Ware (President, International Cytokine Society)
ISICR AND ICS AWARDS PRESENTATIONS Drs. Robert Silverman and John Sims
ICS Awards ISICR Awards Honorary Life Membership Seymour and Vivian Milstein Award ICS Young Investigator Award Honorary Membership ICS Postdoctoral Investigator Award Seymour and Vivian Milstein Young Investigator Awards ICS Outstanding Scholar Award Seymour and Vivian Milstein Travel Awards Christina Fleischmann Award to Young Women Investigators
HONORARY LECTURES 19:00 HON-1 Anti TNF and the Beginning of Anti Cytokine Medicine. Marc Feldmann, Head, Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, UK. ICS Honorary Life Membership Award 19:30 HON-2 Role of Pro-Infl ammatory Cytokines in Carcinogenesis. Giorgio Trinchieri, Cancer and Infl ammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD. ISICR Seymour and Vivian Milstein Award
KEYNOTE LECTURE 20:00 KEY-1 Translational Control of Innate Immunity via IRF-7. Nahum Sonenberg, Department of Biochemistry and McGill Cancer Centre, McGill University, Montréal, QC.
20:30 WELCOME RECEPTION – HOCHELAGA 1 TO 6
Cytokines Montreal 2008 17 Monday, October 13, 2008
PLENARY SESSION 1 LE GRAND SALON
PATTERN RECOGNITION RECEPTORS AND SIGNALING TO INNATE AND ADAPTIVE IMMUNITY
Chairpersons: Luke A.J. O’Neill, Trinity College Dublin (Ireland) Marc Servant, Université de Montréal (Canada) 08:30 PL1-1 The IL-1 Receptor / Toll-like Receptor Superfamily: 10 Years of Progress. Luke A.J. O’Neill, School of Biochemistry and Immunology, Trinity College Dublin, Ireland. 09:00 PL1-2 Innate Recognition Pathways in Dendritic Cells. Caetano Reis e Sousa, Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, UK. 09:30 PL1-3 Insights into Innate Immune Signaling Pathways from Vaccinia Immune Evasion. Andrew G. Bowie, School of Biochemistry and Immunology, Trinity College Dublin, Ireland. 10:00 PL1-4 Role of Nod-like Receptors in Innate and Adaptive Immunity. Dana Philpott, Department of Immunology, University of Toronto, Toronto, ON.
10:30 COFFEE BREAK – FOYER
11:00 PL1-5 New Functions for NLR Proteins: Cell Death and Type I IFN Response. Jenny P-Y Ting, University of North Carolina at Chapel Hill, USA. 11:30 PL1-6 Danger Signals, Interferons and Autoimmune Disease. Anthony Coyle, MedImmune Inc., Gaithersburg, USA. 12:00 PL1-7 Mechanism of Foreign RNA Recognition in the Cytoplasm. Takashi Fujita, Laboratory of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan.
12:30 LUNCH BREAK – ON YOUR OWN
18 Cytokines Montreal 2008 Monday, October 13, 2008
WORKSHOP 1 LE GRAND SALON WORKSHOP 2 MARQUETTE SIGNAL TRANSDUCTION I CYTOKINES IN THE PATHOGENESIS OF INFLAMMATORY DISEASE Chairpersons: Leon Platanias, Northwestern University (USA) Chairpersons: Jennifer Gommerman, University of Toronto (Canada) Paula Pitha, Johns Hopkins University (USA) Josef Schwarzmeier, University of Vienna (Austria) 14:00 WO1-5 14:00 WO2-149 The Role of IRF-5 in the Antiviral and Infl ammatory Response. Mice in which Human TNF is Mediating both Benefi cial and Mumtaz Y. Balkhi, Katherine A. Fitzgerald and Paula M. Pitha, Deleterious Functions: A Model Comparison of Different Johns Hopkins University School of Medicine, Baltimore, MD. Blockade Strategies. A.A. Kruglov, Yu.V. Shebzukhov, A. Kuchmiy, ISICR Honorary Membership Award A.R. Galimov, G. Efi mov, S.I. Grivennikov, D.V. Kuprash, S.V. 14:15 WO1-6 Kozlov, S.A. Nedospasov, German Rheumatism Research Center New pathway for IRF-3-activation by RIG-I that causes its (DRFZ), Berlin, Germany; Engelhardt Institute of Molecular mitochondrial translocation and apoptosis. Saurabh Biology, Russian Academy of Sciences, Moscow, Russia. Chattopadhyay, Joao T. Marques, Bryan Williams and Ganes C. 14:15 WO2-28 Sen, Lerner Research Institute, Cleveland Clinic, Cleveland, OH. Differential Roles of IL-6 and IL-11 in Infl ammation and Tumori- 14:30 WO1-13 genesis. Brendan J. Jenkins, Meri Nadjovska, Claire Greenhill, STAT Phosphorylation-independent Induction of IRF-9 by IFN-β. Louise McLeod, Hazel Tye, Catherine Kennedy, Ceri Fielding, M. R. Sandhya Rani, Tao Wei, Jennifer Shrock, Ed Croze and Nicholas Topley, Simon A. Jones, Matthias Ernst, and Paul J Hert- Richard M. Ransohoff, Neuroinfl ammation Research Center, zog, Monash Institute of Medical Research, Clayton, Australia. Department of Neurosciences, Cleveland Clinic, Cleveland, OH, 14:30 WO2-30 Bayer Healthcare Pharmaceuticals Inc., Richmond, CA. Inhibition of IL-23 Prevents Disease in an Inducible Psoriatic- 14:45 WO1-3 like Mouse Model. Jennifer Towne, Donna Shows, Huyen Dinh, Roles of JAK-STAT Pathway Factors in Antiproliferative Yu Zhang, Charley Dean, Esther Trueblood, Keith Bailey, John Activities of Human IFN-α and IFN-γ: A Comprehensive Sims, and Hal Blumberg, Department of Infl ammation Research, Assessment in Human Ovarian Adenocarcinoma OVCAR3 Cells. Amgen, Seattle, WA. Takaya Tsuno, Josef Mejido, Tongmao Zhao, Angel Morrow and 14:45 WO2-41 Kathryn C. Zoon, National Institute of Allergy and Infectious TL1A-DR3 Interactions Drive Immunopathology Mediated by Diseases, National Institutes of Health, Bethesda, MD. Multiple T-cell Subsets. Richard M. Siegel, Erin Kahle, Krishika 15:00 WO1-1 Acharya, Ivan Fuss, Eddie Wang, and Francoise Meylan, Dual Regulatory Roles of the Phosphatidylinositol 3-kinase in Immunoregulation Unit, NIAMS, NIH, Bethesda, MD. Interferon Signaling. Surinder Kaur, Antonella Sassano, Ajith M. ICS Young Investigator Award Joseph, Beata Majchrzak-Kita, Elizabeth A. Eklund, Eleanor N. 15:00 WO2-34 Fish, Amit Verma, Saskia M. Brachmann, and Leonidas C. Mutations in the Interleukin-1 Receptor Antagonist Cause a Platanias, Robert H. Lurie Comprehensive Cancer Center, North- New Autoinfl ammatory Disease. Seth L Masters, Ivona Aksen- western University Feinberg School of Medicine, Chicago, IL. tijevich*, Polly J Ferguson, Matthew G Booty, Arian Laurence, 15:15 WO1-7 Hang Pham, Deborah L Stone, Edward W Cowen, Nicole Plass, Similarities and Distinctions of STAT Nuclear Traffi cking. Janaki Xinyu Bing, Gillian I Clarke, Kamal Ohson, Hatem I El-Shanti, Iyer, Hui-Chen Chen, Velasco Cimica and Nancy C. Reich, Annet van Royen, Joost Frenk, Proton Rahman, Elaine F Remmers, Department of Molecular Genetics & Microbiology, Stony Brook Paul Dancey, Daniel L Kastner and Raphaela Goldbach-Mansky, University, Stony Brook, New York, NY. Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD. 15:30 WO1-12 ICS Post-Doctoral Investigator Award The Pathophysiological Actions of Interferon-α in the Central Nervous System are Exacerbrated by the Absence of IRF9. 15:15 WO2-112 Markus J. Hofer, Wen Li and Iain L. Campbell. School of Regulation of Infl ammatory Responses by IL-17F. Chang SH, Molecular and Microbial Biosciences and Bosch Institute, Yang XO, Park H, Nurieva R, Shah B, Acero L, Wang YH, Schluns University of Sydney, NSW, Australia. KS, Broaddus RR, Zhu Z, Dong C. Department of Immunology, MD Anderson Cancer Center, Houston, TX. 15:45 WO1-4 ICS Post-Doctoral Investigator Award Parameters Governing Interferon alpha2/beta Differential Activities. Ignacio Moraga Gonzalez, Josiane Ragimbeau, Gilles 15:30 WO2-32 Uzé and Sandra Pellegrini, Cytokine Signaling Unit, CNRS URA The Role of IL6-Transsignaling in Acute and Chronic Infl amma- 1961, Institut Pasteur, Paris, France. tion. B. Rabe, Athena Chalaris, Nina Adam, Krzysztof Paliga, Hans Lange, Tamas Laskay, Ceri A. Fielding, Georg H. Waetzig, 16:00 COFFEE BREAK – FOYER Dirk Seegert, Anwen S. Williams, Simon A. Jones, Christian Sina, Stefan Rose-John and Jürgen Scheller, Department of Biochem- istry, Christian-Albrechts-University, Kiel, Germany. 15:45 WO2-35 Role of the IFN-inducible Gene IFI16 in the Pathogenesis of Autoimmune Diseases. Gugliesi Francesca, Michele Mondini, Marco De Andrea, Simone Sponza, Rossella Baggetta, Marisa Gariglio, and Santo Landolfo, Department of Public Health and Microbiology, University of Turin, Turin, Italy. 16:00 COFFEE BREAK – FOYER Cytokines Montreal 2008 19 Monday, October 13, 2008
WORKSHOP 3 JOLLIET WORKSHOP 4 DULUTH CYTOKINES AND CHEMOKINES: MECHANISMS OF ACTION IMMUNE CELL ACTIVATION AND FUNCTION Chairpersons: Alberto Mantovani, Istituto Clinico Humanitas IRCCS (Italy) Chairpersons: Scott Durum, NIH (USA) Eliane Meurs, Institut Pasteur (France) Michael Tovey, CNRS-Villejuif (France) 14:00 WO3-113 14:00 WO4-148 Major Differences in the Response of Primary Human Blood ‘Re-educating’ Macrophages in Infection and Cancer by Cells to IFN-β. Anette H. H. van Boxel-Dezaire, Joana A. Zula, Targeting NF-κB. Toby Lawrence, Carol Fong and Thorsten Yaomin Xu, Richard M. Ransohoff, James W. Jacobberger, and Hagemann, Centre for Cancer and Infl ammation, Institute of George R. Stark, Department of Molecular Genetics, Cleveland Cancer and CR-UK Clinical Centre, Barts and The London Clinic Foundation, Cleveland, OH. School of Medicine and Dentistry, London UK. 14:15 WO3-114 ISICR Young Investigator Award A New Composite Cytokine Formed by the Interleukin-27 14:15 WO4-29 Subunit P28 and Soluble Receptor CLF Activating Human Antagonistic Role of STAT6 for Regulatory T-cells. Svetlana P. Natural Killer Cells. Sandrine Crabé, Angélique Guay-Giroux, Chapoval, Ann E. Kelly-Welch, Elizabeth Smith, and Achsah D. Dorothée Duluc, Aurélie Tormo, Pascale Jeannin and Jean- Keegan, Center for Vascular and Infl ammatory Diseases, François Gauchat, Département de pharmacologie, Université University of Maryland School of Medicine, Baltimore, MD. de Montréal, Montreal, QC. 14:30 WO4-152 14:30 WO3-116 Negative Feedback Regulation of T-cells: Interleukin 2 and Cell-specifi c Induction of CXCL9 by IFN-γ is Determined by PU.1. FOXP3 Reciprocity. Zoran Popmihajlov and Kendall A. Smith, Sally L. Carter, Marcus Müller, Wen Li, Peter M. Manders, Iain Division of Immunology, Department of Medicine, Weill Cornell L. Campbell, School of Molecular and Microbial Biosciences Medical College, New York, NY. and the Bosch Institute, University of Sydney, Sydney, NSW, 14:45 WO4-158 Australia. Cytokines Control CD4+ CD25+ Foxp3+ Regulatory T-cell 14:45 WO3-118 Survival and their Mechanism of Suppression. Pushpa Oncostatin-M Induces Accumulation of Airway Eosinophils Pandiyan and Michael Lenardo, Laboratory of Immunology, and Extracellular Matrix Through STAT6–dependent and NIAID, Bethesda, MD. –independent Pathways. Dominik K. Fritz, Christine Kerr, Walid ICS Post-Doctoral Investigator Award Khan, Fernando Botelho, David Smyth, Martin Stampfl i, Carl D. 15:00 WO4-151 Richards, Centre for Gene Therapeutics, Department of Pathology Interferon Regulatory Factor-1 Negatively Regulates CD4+CD25+ and Molecular Medicine, McMaster University, Hamilton, ON. Regulatory T-cells by Repressing FOXP3. Alessandra Fragale, 15:00 WO3-119 Lucia Gabriele, Emilia Stellacci, Paola Borghi, Edvige Perrotti, TGF-β Promotes Th17 Cell Development Through Inhibition of Ramona Ilari, Angela Lanciotti, Anna Lisa Remoli, Massimo SOCS-3. Hongwei Qin, Lanfang Wang, Charles O. Elson, Sandrine Venditti, Filippo Belardelli and Angela Battistini, Department of A. Niyongere, Sun Jung Lee, Etty N. Benveniste, Craig L. Infectious, Parasitic and Immunomediated Diseases, Istituto Maynard, Casey T. Weaver, Kevin Roarty, Rosa Serra, and Yingzi Superiore di Sanità, Rome, Italy. Cong, Department of Cell Biology, University of Alabama, 15:15 WO4-31 Birmingham, AL. ICS Young Investigator Award A Role for IFN-β in Limiting TH17 Cell Accumulation in Multiple 15:15 WO3-120 Sclerosis. Carole Galligan, Ramtin Rahbar, Beata Majchrzak, The IL-1 Family Member IL-1F7 Reduces Innate Immunity by Thomas Murooka, Ehtesham Baig, and Eleanor Fish, Toronto Inhibiting Toll-like Receptor and IL-1 Signaling Pathways. General Research Institute, University Health Network, Marcel F. Nold, Claudia A. Nold-Petry, Jarod A. Zepp, Philip Toronto, ON. Bufl er, and Charles A. Dinarello, Department of Medicine, 15:30 WO4-154 University of Colorado Health Sciences Center, Denver, CO. Interferon-gamma Prevents Death of Bystander Neurons During 15:30 WO3-121 CD8 T-cell Responses in the Brain. Kirsten Richter, Jürgen Differential Control of T-Cell Responses by Classical IL-6 Hausmann and Peter Staeheli, Department of Virology, University Receptor Signaling and IL-6 Trans-signaling. Gareth W. Jones, of Freiburg, Freiburg, Germany. Rachel M. McLoughlin, Victoria J. Hammond, Clare R. Parker, 15:45 WO4-211 John D. Williams, Raj Malhotra, Jürgen Scheller, Stefan Rose- Micro-Injection of Inositol Pyrophosphates Induces Apoptosis John, Nicholas Topley and Simon A. Jones, Department of in Head and Neck Squamous Cell Carcinoma Cells. Bei H. Medical Biochemistry and Immunology, School of Medicine, Morrison, Eric Lamarre, Joseph A. Bauer, Judith Drazba, Glenn Cardiff University, Cardiff, UK. D. Prestwich, and Daniel J. Lindner, Center for Hematology and 15:45 WO3-125 Oncology Molecular Therapeutics, Taussig Cancer Institute, Glycosylated Recombinant Simian Interleukin-7 Provokes Cleveland Clinic, Cleveland, OH. Immediate and Massive Chemokine-dependent T-cell Homing 16:00 COFFEE BREAK – FOYER in Healthy Rhesus Macaques. Stéphanie Beq, Sandra Rozlan, David Gautier, Raphaelle Parker, Véronique Mersseman, Clémentine Schilte, Brigitte Assouline, Iann Rancé, Pascal Lavedan, Michel Morre and Rémi Cheynier, Département de Virologie, Institut Pasteur, Paris, France. 16:00 COFFEE BREAK – FOYER
20 Cytokines Montreal 2008 Monday, October 13, 2008
SYMPOSIUM 1 LE GRAND SALON
FUNCTIONS OF INTERFERON STIMULATED GENES
Chairpersons: Ganes Sen, Lerner Research Institute, Cleveland Clinic (USA) Michael David, University of California, San Diego (USA) 16:30 SY1-1 Induction, Functions and Viral Evasion of the ISG56 Family of Genes. Ganes C. Sen, Lenette Lu, Volker Fensterl, Christine White, Michifumi Yamashita, Parama Saikia, Saurabh Chattopadhyay and Saumendra N. Sarkar, Lerner Research Institute, Cleveland Clinic, Cleveland, OH. 17:00 SY1-2 Infl ammation-Induced microRNAs in B-cell Lymphoma. Irene Pedersen, Ana Miletic, Carlo Croce, Kirsten Gronbaek, Robert Rickert and Michael David, University of California, San Diego, La Jolla, CA. 17:20 SY1-3 STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Glen Barber, University of Miami School of Medicine, Miami, FL. 17:40 SY1-4 The Gait System Defi nes a Post-Transcriptional Regulon that limits Myeloid Expression of Infl ammatory Genes. Paul L. Fox, Rupak Mukhopadhyay, Partho Sarothi Ray, Abul Arif, and Jie Jia, Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
SYMPOSIUM 2 MARQUETTE / JOLLIET
BIOLOGY AND REGULATION OF THE TNF SUPERFAMILY
Chairpersons: Carl Ware, LaJolla Institute of Allergy and Immunology (USA) Genhong Cheng, University of California, Los Angeles (USA) 16:30 SY2-5 Regulation of Immunity through the LTβ Receptor and HVEM-BTLA Circuit. Carl F. Ware, Tim Cheung, Carl DeTrez, Kirsten Schneider, John Sedy, Claire Jacquin, Satoshi Fukuyama, Hideki Sanjo, Brian Greenberg, Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA. 17:00 SY2-6 Cells and Signals in Models of TNF-driven Pathophysiology. George Kollias, Alexander Fleming Institute, Vari, Athens, Greece. 17:20 SY2-7 TNF-like Proteins in Organogenesis. Marja L. Mikkola, Sylvie Lefebvre, Ingrid Fliniaux, Irma Thesleff, Developmental Biology Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland. 17:40 SY2-8 Noncanonical NF-κB Activation Requires the Coordinated Assembly of the cIAP1/2-NIK Regulatory Complex by TRAF2 and TRAF3. Genhong Cheng, Brian J. Zarnegar, Yaya Wang, Douglas J.Mahoney, Paul W. Dempsey, Herman H. Cheung, Jeannie He, Travis Shiba, Xiaolu Yang, Wen-chen Yeh, Tak W. Mak, Robert G. Korneluk, Department of Microbiology, Immunology & Molecular Genetics, University of California Los Angeles, Los Angeles, CA.
Cytokines Montreal 2008 21 Monday, October 13, 2008
POSTER DISCUSSION 1 18:00 – 19:30 HOCHELAGA 2 Christina Luig, Stephan Ludwig, Institute of Molecular Virology, Center for Molecular Biology of Infl ammation (ZMBE), Münster, Germany. 18:15 PD1-78 PP1-15 TREM-1 Expression is Increased in the Synovium of Rheuma- Gene and Protein Expression Observed After Treatment of DAUDI Cells toid Arthritis Patients and Induces the Expression of Pro- with IFN-α2c and IFN-α21β. Joseph Bekisz, Josef Mejido, Timothy infl ammatory Cytokines. Jun Kuai, Bernard Gregory, Andrew Hill, Veenstra and Kathryn Zoon, National Institute of Allergy and Infectious Debra D. Pittman, Jeffrey L. Feldman, Tom Brown, Brenda Carito, Diseases, National Institutes of Health, Bethesda, MD. Margot O’Toole, Renee Ramsey, Kathleen M. Shields, Jonathan T Beech, Jagdeep Nanchahal, Marc Feldmann, Brian M Foxwell, PP1-16 Fionula M Brennan, Wyeth Research, Departments of IRS1 Expression Enhances the Sensitivity of 32D Cells to Chemo- Infl ammation, Cambridge, MA. therapy-induced Cell Death. Holly A. Porter, and Achsah D. Keegan, Center for Vascular and Infl ammatory Diseases, Marlene and Stewart 18:30 PD1-44 Greenebaum Cancer Center, University of Maryland School of Medicine, The Overexpression of DAP12 Leads to Gain of Osteoclast Baltimore, MD. Function in vitro with Age-related Onset of Osteopenia in vivo. Geneviève Despars, Adrienne Anginot, Eric Vivier, Marlène PP1-17 Mazzorana, and Pierre Jurdic, Cell Biology and Bone Physio- Identifi cation of IFN-alpha-induced Genes and Proteins that are As- pathology Laboratory, Institut de Génomique Fonctionnelle de sociated with Antiviral Activity in DAUDI Cells. Hana Schmeisser, Josef Lyon Université de Lyon; Institut Fédératif Biosciences Gerland Mejido, Kathryn C. Zoon, NIAID, National Institutes of Health, Bethesda, Lyon Sud; Université Lyon 1, CNRS, INRA, Ecole Normale MD. Supérieure de Lyon, France. PP1-18 18:45 PD1-57 Induction of ISGF3 in Response to Interferon Gamma in Human Cells. Neo-Organoid of Mesenchymal Stem Cells Engineered to Angel N. Morrow, Hana Schmeisser, Takaya Tsuno, and Kathryn C. Zoon, Secrete a CC-Chemokine Chimeric Fusokine Reverses EAE. National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Moutih Rafei, Philippe Campeau, Elena Birman, and Jacques MD. Galipeau, Montreal Center for Experimental Therapeutics in PP1-19 Cancer, Jewish General Hospital, McGill University, Montreal, Simultaneous Detection of STAT1, STAT3, and STAT5 Activation in QC. Response to Interferons. Mary M. Brodey, Wei Zheng, Jimin Wang, and 19:00 PD1-180 Kevin Reagan, Invitrogen Corporation, Camarillo, CA.
Recruitment of Stat1 to Chromatin is Required for Interferon- PP1-20 induced Serine Phosphorylation of Stat1 Transactivation Alpha Lipoic Acid Attenuates Cadmium-induced Infl ammatory Cytokine Iwona Sadzak, Melanie Schiff, Edward Yang, Barbara Domain. Expression and Apoptosis in HepG2 Cells. José G. Macías-Barragán, Schaljo and Pavel Kovarik, Max F. Perutz Laboratories, University Miriam R. Bueno-Topete, Juan S. Armendáriz-Borunda, Selene G. of Vienna, Vienna, Austria. Huerta-Olvera, Fernando R. Siller-López, Instituto de Biología Molecular HOCHELAGA 2-6 en Medicina y Terapia Génica, Universidad de Guadalajara, México. POSTER SESSION 1 18:00 – 19:30 & MARQUETTE PP1-21 PP 1 – SIGNAL TRANSDUCTION I Functional Analyses of Three Human TYK2 Variants. Josiane Ragim- beau, Milica Gakovic, Maija L. Eloranta and Sandra Pellegrini, Cytokine PP1-8 Signaling Unit, CNRS URA 1961, Institut Pasteur, Paris, France. A Role for JAKs and STATs in Chemoresistance? Catarina Ramos do Carmo, Michael J. Seckl and Ana P. Costa-Pereira, Imperial College Lon- PP1-22 don, Faculty of Medicine, Department of Oncology/SORA, Hammersmith The dsRNA Binding Protein Pact in Innate Immune Signaling. Christine Hospital, London, UK. L. White, Gregory A. Peters, Benjamin K. Dickerman, Avanti Desai and Ganes C. Sen, Department of Molecular Genetics, Cleveland Clinic, PP1-9 Cleveland, OH. Type I Interferon-regulated Gene Expression in the Absence of IRF9, STAT1 OR STAT2 in Murine Mixed Glial Cell Cultures. Wen Li, Markus PP1-23 J. Hofer, Sally L. Carter, Dale Hancock, Gareth Denyer, Iain L. Campbell, Impaired Signaling in Memory T-cells during HIV Infection. Yu Shi, School of Molecular and Microbial Biosciences, University of Sydney, Lydie Trautmann, Yoav Peretz, Joumana Zeidan, Bader Yassine-Diab, Sydney, NSW, Australia. Zhong He, Mohamed-Rachid Boulassel, Jean-Pierre Routy, Elias K. Had- dad and Rafi ck-Pierre Sékaly, Laboratory of Immunology, Department of PP1-10 Microbiology and Immunology, Université de Montréal and CR-CHUM, X-Linked Inhibitor of Apoposis Protein Inhibits RIG-I Signalling Path- NSERM U743 and CUSM, Montréal, QC. way. Peyman Nakhaei, Thibault Mesplède, Qiang Sun, Simon Leveillé, Robert G. Korneluk and John Hiscott, Molecular Oncology Group, Lady PP1-24 Davis Institute-Jewish General Hospital, McGill University, Montreal, OCT-6 (POU3F1, TST-1, SCIP) is an Interferon-inducible Protein. Elisa- Canada. beth Hofmann, Ursula Reichart, Christian Gausterer, Dies Meijer, Math- ias Müller and Birgit Strobl, Institute of Animal Breeding and Genetics, PP1-11 University of Veterinary Medicine Vienna, Austria. Nuclear Transport Dynamics of STAT6. Hui-Chen Chen, Nancy C. Reich, Department of Molecular Genetics and Microbiology, Stony Brook PP1-25 University, NY. Role of Syk in IL-4-induced Human Neutrophils. Jamila Ennaciri, Denis Girard, Université du Québec, INRS-Institut Armand-Frappier, QC. PP1-14 The Function of MAP-kinase Activated Protein Kinases in Infl uenza A PP1-26 Virus Infection–Linking MAPK Signalling to Protein Kinase R Inhibition. Molecular and Genetic Analysis of the Resistance of the Mouse Strain SPRET/Ei to Endotoxemia and Gram-negative Sepsis. Lien Dejager, Iris 22 Cytokines Montreal 2008 Monday, October 13, 2008
Pinheiro, Filip Van Hauwermeiren and Claude Libert, Molecular Mouse PP2-47 Genetics Unit, DMBR, VIB and Ghent University, Ghent, Belgium. Interleukin-22 in Sepsis. Tobias M. Bingold, Elisabeth Ziesché, Bertram Scheller, Christian D. Sadik, Katharina Franck, Lara Just, Sven Sartorius, PP 2 – CYTOKINES IN THE PATHOGENESIS OF INFLAMMATORY Mathis Wahrmann, Heimo Wissing, Bernhard Zwissler, Josef Pfeilschift- DISEASE er and Heiko Mühl, Pharmazentrum frankfurt/ZAFES, General Pharma- PP2-33 cology, Goethe-University School of Medicine, Frankfurt, Germany. The Role of DCIR in the Development of Autoimmune Diseases. Noriyuki Fujikado, Shinobu Saijo, Tomo Yonezawa, Kazusuke Shimamori, Akina PP2-48 Ishii, Sho Sugai, Hayato Kotaki, Katsuko Sudo, Masato Nose, Yoichiro Spleen Tyrosine and Tyrosine-protein Kinases are Involved in the Marina Iwakura, Center for Experimental Medicine, The Institute of Medical Sci- Infl ammasome Activation by Hemozoin in Human Monocytes. T. Shio, Myriam Savaria, Martin Olivier, Department of Microbiology and ence, University of Tokyo, Tokyo, Japan. Immunology, Centre for the Study of Host Resistance, McGill University PP2-36 Health Centre, Montréal, QC. Serum Cytokine and Chemokine Profi les of individuals with Myalgic PP2-49 Encephalomyelitis (ME) Reveal Distinct Pathogen Associated Sig- Regulation of TLR Mediated Responses in the Peritoneal Cavity. Chantal natures. Vincent C. Lombardi, Doug Redelman, Darren C. White, Marc S Colmont, Mario O Labéta, Anne-Catherine Raby, Barbara Coles, Simon Fremont, Kenny DeMeirleir, Daniel Peterson and Judy A. Mikovits, Whit- A Jones and Nicholas Topley, Department of Medical Biochemistry and temore Peterson Institute, Reno, NV, USA; Dept. of Microbiology and Immunology, Cardiff University, Cardiff, UK. Immunology, University of Nevada, Reno, NV. PP2-37 PP2-50 The Identifi cation of Novel CSF-1 Target Genes in Human Macrophages. A Humanized BAC Transgenic/Knockout Mouse Model for Human Katharine M. Irvine, Melanie R. Andrews, Manuel A. Fernandez, Robert Caspase-12 Polymorphism. Garabet Yeretssian, Michael R. Hayden, G. Parton, Christopher J. Burns, Stephen Su, Andrew F. Wilks, David A. Donald W. Nicholson and Maya Saleh, Department of Medicine, Division Hume, M. J. Sweet, Institute for Molecular Biosciences, The University of Critical Care, McGill University, Montreal, QC. of Queensland, Brisbane, Queensland, Australia. PP2-52 Heather R. Conti, PP2-38 Defi ning Host T-cell Responses in Oral Candidiasis. Fang Shen, Namrata Nayyar, Eileen Stocum, Matthew J. Lindemann, Leishmania Induces Inactivation of the Macrophage AP-1 Transcrip- Allen Ho, Patricia Masso-Welch, Mira Edgerton, Sarah L. Gaffen, Dept. tion Factor and its Subunits Through its Surface Protease GP63. Irazú Contreras, Ma. Adelaida Gomez, Oliver Nguyen, Robert McMaster and of Oral Biology, School of Dental Medicine, University at Buffalo, SUNY, Martin Olivier, Department of Microbiology and Immunology, McGill Buffalo NY. University, Montreal, QC. PP2-53 PP2-39 CNTF Receptor Activation Modulates Sensitivity to Cold, to TRPA1 Ago- Marie-Claude Letellier, Cytokines in Guillain Barre Syndrome. Shripad A. Patil and Arun B.Taly, nist and Infl ammation-Induced Hyperalgesia. Dept. of Neuro-Microbiology and Neurology, National Institute of Mental Jean-Sébastien Walczak, Sandrine Crabé, Marie Gingras, François Ber- Health and Neurosciences, Bangalore, India. thod, Greg Elson, Pierre Beaulieu and Jean-François Gauchat, Départe- ment de pharmacologie, Université de Montréal, Montreal, QC. PP2-40 Expression and Function of Schlafen-4 in Macrophage Biology and PP2-54 A Soluble Form of the LDL Receptor Inhibits Hepatitis B Virus Replica- Infl ammation. Wendy JM van Zuijlen, K Schroder, V Garceau, MJ Sweet, Ariel Werman, Brent E. Korba, Ben Alkahe, Danit Finkelsh- S Kellie, DA Hume, Institute for Molecular Bioscience, University of tion in vitro. tein, Sergey Bujanover, Daniela Novick, Ernest Vinocour and Menachem Queensland, Brisbane, QLD, Australia, CRC for Chronic Infl ammatory Rubinstein, Dept. of Molecular Genetics, Weizmann Institute of Science, Diseases, Parkville, Victoria, Australia. Rehovot, Israel. PP2-42 Absence of IL-22 Aggravates Dextran-sulfate Induced Colitis. Laure PP2-55 Katherine Dumoutier and Jean-Christophe Renauld, Ludwig Institute for Cancer Infl ammatory Caspases Modulate Host Response to Malaria. Labbé, Jenny Miu, Mifong Tam, Mary Stevenson, Maya Saleh, Microbi- Research, Brussels, Belgium. ology and Immunology, McGill University, Montreal, QC. PP2-43 Adipokines and Tumor Necrosis Factor-α in Peripheral Arterial Occlu- PP2-56 Characterization of an Anti-infl ammatory and Immunomodulatory sive Disease. Claudia Gherman, Adriana Muresan, Adriana Filip, Anca Shaomin Hu and Ming Chiu Cristea, Aurel Mironiuc, Laura Palcau, Diana Sacui, Surgical Clinic No.2, Protein, SJ16, of Schistosoma Japonicum. Fung, Department of Biology, Chinese University of Hong Kong, Hong University of Medicine and Pharmacy “Iuliu Hatieganu” Cluj-Napoca, Kong, China. Romania. PP2-45 PP2-57 Key Role of the Protease ADAM17 in the Biology of Interleukin-6, TNFα Neo-Organoid of Mesenchymal Stem Cells Engineered to Secrete a Moutih Rafei, Philippe and the EGF-Receptor. Stefan Rose-John, Athena Chalaris, Krzysztof CC-Chemokine Chimeric Fusokine Reverses EAE. Paliga, Karina Reiss, Paul Saftig, Joanna Cichy, and Jürgen Scheller, Campeau, Elena Birman, and Jacques Galipeau, Montreal Center for Department of Biochemistry, Christian-Albrechts-Universität, 24098 Kiel, Experimental Therapeutics in Cancer, Jewish General Hospital, McGill Germany. University, Montreal, QC. PP2-46 PP2-58 Modulation of FoxP3 Expression and Severity of Experimental IBD by Effect of Coenzyme Q10 on LPS-induced Secretion of the Pro-infl am- Constance Estrogen Receptor Isotype and their Agonist. Rekha Rani Garg, Muham- matory Cytokines and Chemotactic Factors in THP-1 Cells. madreza Sachedina, Fabio Cominelli, Brian K. Reuter, and Theresa T. Schmelzer, Gerti Lorenz, Inka Lindner, Frank Döring, Department of Pizarro, Digestive Health Research Center, University of Virginia Health Molecular Nutrition, Institute of Human Nutrition and Food Science, System, Charlottesville, VA. University of Kiel, Germany. Cytokines Montreal 2008 23 Monday, October 13, 2008
PP2-59 Institute of Basic Medical Sciences, College of Medicine, National Myelin-phagocytosing Macrophages in Isolated Sciatic and Optic Cheng Kung University, Tainan, Taiwan. Denise van Rossum, Nerves Reveal a Unique Reactive Phenotype. PP2-70 Sören Hilbert, Silke Straßenburg, Uwe-Karsten Hanisch and Wolfgang Plasma Concentration sE-selectin in Patients with Postoperative Infec- Brück, Institute for Neuropathology, University of Göttingen, Göttingen, tious Complications from Gastrointestinal Surgery for Stomach Cancer. Germany. Zelenskiy Alexey, Kazakov Sergey, State postgraduate medical educa- PP2-60 tion of the Defense Ministry of Russian Federation, Moscow, Russia. Immunomodulatory Effects of Drug Metabolites: An Unexpected Role of PP2-71 James Li, Howard Sulfamethoxazole in the Regulation of Infl ammation. Tumor Cells Induce Interferon Responsive Genes in Primary Endothe- Yim, Michael Rieder, Davy Lee, Allan Lau, Cytokine Biology Group, lial Cells in a Polar Fashion. Claudia Nemeth, Herwig P. Moll, Harald Department of Paediatrics and Adolescent Medicine, and Bio-Screen- Freudenthaler, Anna Zommer, Christine Brostjan, Department of Surgery ing Unit, Li Ka Shing Faculty of Medicine, The University of Hong Kong, – Research Laboratories, Medical University of Vienna, Austria. Pokfulam, Hong Kong, China. PP2-72 PP2-61 Pirfenidone Blunts Induction of Bleomycin Induced Genes Associated Gamma Interferon-induced Inhibition of Growth Rickettsia Prowazekii with Idiopathic Pulmonary Fibrosis in Mice. Milton W. Taylor, Takuma Jenifer in Fibroblasts is not Alleviated by Addition of Iron-transferrin. Tsukahara, Osman N Ozes, Jena Derrick, Sarah K.Stevens, Lawrence Turco and Herbert H. Winkler, Department of Biology, Valdosta State M.Blatt, Department of Biology, Indiana University, Bloomington, IN. University, Valdosta, GA. PP2-73 PP2-62 Multiplex Immunoassays for the Quantifi cation of Rhesus and Cyno- Impact of Hepatitis B Viral Load on Serum IL-6, MMP-9 and Alpha-feto- molgus Monkey Cytokines. Mary M. Brodey, Nina Liu, Jimin Wang, and protein Levels and their Correlation with Liver Injury in Chronic Hepa- Kevin Reagan, Invitrogen Corporation, Camarillo, CA. titis B Infection. Ghada F. Helaly, Department of Microbiology, Medical Research Institute, University of Alexandria, Alexandria, Egypt. PP2-74 Inhibition by AT-1001 of Epithelial Tight Junction Permeability Caused PP2-63 by Cytokines from PT-Gliadin Stimulated Human PBMC. Malarvizhi Paired Perhipheral Blood and Genital Tract Cytokine and Chemokine Durai, Neil Poloso, Kelly Kitchens, Robert Somerville; Rosa Carrasco, Levels with Non-protease Inhibitor Based Antiretrovirals in HIV Infect- Shobha Gopalakrishnan, Amir Tamiz, Niranjan Pandey and Sefi k S. Ajay Wanchu, Ravinder Kaur Sachdeva, Suresh Pallikkuth, ed Women. Alkan, ALBA Therapeutics, Baltimore, MD. Rashmi Bagga, Nancy Malla, Meera Sharma, Department of Internal Medicine, PGIMER, Chandigarh, India. PP2-75 Leucine Modulates the Effects of the Walker Tumour’s Proteolysis-in- PP2-64 ducing Factor in C2C12 Muscle Cells. Estela M. Gonçalves, Maria Cris- Contribution of cerebral proinfl ammatory cytokines to hepatic encepha- tina C. Gomes-Marcondes, Laboratory of Nutrition and Cancer, Depart- lopathy in experimental acute liver failure: effect of interleukin-1beta ment of Physiology and Biophysics, Institute of Biology, State University Chantal receptor and tumor necrosis factor-alpha receptor knockouts. of Campinas - UNICAMP, Campinas, SP, Brazil. Bemeur, Paul Desjardins and Roger F. Butterworth, Unité de recherche en neurosciences, Hôpital St-Luc du CHUM, Montréal, QC. PP2-76 Inhibition of Cyclooxygenase-2 in Severe Acute Pancreatitis: Cytokines PP2-65 α Levels and Organ Dysfunction. Chooklin S., Bihalskyy I., Lyba M., Medi- Serum Concentration of TNF- , IL-6, IL-8, and MCP-1 in Retired Workers cal University, Lviv, Ukraine. Exposed to Mineral Dusts. Jae Hoon Shin, Jong Seong Lee, JooHwan Hwang, Byung soon Choi, Center for Occupational Lung Diseases, PP2-77 WAMCO, Ansan, Korea. The Role of IgE Antibodies in Protection Against P.falciparum. Reem Mohammed, Marita Troye Bloomberg, Muntasir Eltayeb, Ibrahim Elhas- PP2-66 san, Institute of Endemic Diseases, University of Khartoum, Khartoum, Quantitative Cytokine and Cytokine Receptors Profi ling with Evidence Sudan. Biochip Arrays. J. Porter, F.M. McPhillips, V. Toner, A. Beattie, R.I. Mc- Connell, S.P. Fitzgerald, Randox Laboratories Ltd., Crumlin, Northern PP2-78 Ireland, UK. TREM-1 Expression is Increased in the Synovium of Rheumatoid Arthritis Patients and Induces the Expression of Pro-infl ammatory PP2-67 Cytokines. Jun Kuai, Bernard Gregory, Andrew Hill, Debra D. Pittman, Biological Role of Hepatocyte-derived Interleukin-1 Receptor Antago- Jeffrey L. Feldman, Tom Brown, Brenda Carito, Margot O’Toole, Renee Celine Lamacchia, Gaby nist in a Model of Systemic Infl ammation. Ramsey, Kathleen M. Shields, Jonathan T Beech, Jagdeep Nanchahal, Palmer, Audrey Benoit, Dominique Talabot and Cem Gabay, Division of Marc Feldmann, Brian M Foxwell, Fionula M Brennan, Wyeth Research, Rheumatology and Department of Pathology & Immunology, University Departments of Infl ammation, Cambridge, MA. of Geneva School of Medicine (CMU), Geneva, Switzerland. PP2-79 PP2-68 Therapeutic Potential of IL-27 for Infl ammatory and Autoimmune Biological Role of Myeloid Cell-derived Interleukin-1 Receptor An- Diseases. Yoshiyuki Miyazaki, Hitoshi Nakashima, and Hiroki Yoshida, Celine Lamacchia, Gaby Palmer, tagonist in Collagen-induced Arthritis. Department of Biomolecular Sciences, Faculty of Medicine, Saga Uni- Audrey Benoit, Dominique Talabot and Cem Gabay, Division of Rheuma- versity, Saga, Japan. tology and Department of Pathology & Immunology, University of Geneva School of Medicine (CMU), Geneva, Switzerland. PP2-80 Low Dose Administration of Cytokines Protects from Allergic Asthma. PP2-69 Marco Palazzo, Silvia Gariboldi, Laura Zanobbio, Giuseppina F Dusio, Interleukin-20 Induced Cell Death in Renal Epithelial Cells and was Valentina Mauro and Cristiano Rumio, MIL- Mucosal Immunity Labora- Hsing-Hui Li, and Ming-Shi Chang, Associated with Acute Renal Failure. tory, Department of Human Morphology, Università degli Studi di Milano, Milan, Italy. 24 Cytokines Montreal 2008 Monday, October 13, 2008
PP2-81 PP2-90 Mechanism of Action of Sifnalimumab, a Human IFN-α Neutralizing Modulation of macrophage infi ltration and infl ammatory activity by the Monoclonal Antibody. R. Cibotti, V. Oganesyan, M. Liang, I. Vainshtein, phosphatase SHP-1 in virus-induced demyelinating disease. George C. Morris, J. Riggs, W. Dall’Acqua, L. Roskos. P. Kiener and A. J. Coyle, P. Christophi, Chad A. Hudson, Ross Gruber, Michael Panos, and Paul Medimmune, Inc. One Medimmune Way, Gaithersburg, MD. T. Massa, Department of Neurology and Department of Microbiology & PP2-82 Immunology, SUNY Upstate Medical University, Syracuse NY. The Activity State of NF-κB is Associated with the Internalization and PP2-91 Intracellular Survival of Staphylococcus Aureus in Endothelial Cells. The Use of Cytokine Response Profi les to Inform Viral Vaccine Develop- Javier Oviedo-Boyso, Marcos Cajero-Juárez, Juan J. Valdez-Alarcón, ment. Stacie Lambert, Kathy Wang, Jennifer Woo, George Kemble, Alejandro Bravo-Patiño and Víctor M. Baizabal-Aguirre, Laboratory of MedImmune, LLC, Mountain View CA. Molecular Immunology, Centro Multidisciplinario de Estudios en Bio- PP2-92 tecnología, Facultad de Medicina Veterinaria y Zootecnia, Universidad IFN Gamma Modulation by IL 18, IL 4 and IL 10 during BEHCET Disease Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, México. Evolution. Houda Belguendouz, Djamel Messaoudene, Mohammed E-mail: [email protected]. L. Ahmedi, Karima Lahmar, Fatma Z. Ider, Oussama Medjber, Dahbia PP2-83 Hartani and Chafi a Touil-Boukoffa, “Cytokines & NO Synthases” group, Acceleration of Aging-associated Increase in Infl ammatory Markers MCB laboratory, FSB, USTHB, Algiers, Algeria. and Attenuation of the Immune System Among Atomic-bomb Survivors. PP2-93 Tomonori Hayashi, Yoichiro Kusunoki, Yukari Morishita, Hiroko Nagamura, PGE2-mediated Chronic Infl ammation: a Role for IFN-γ? Alex G. Therien, Mayumi Maki, Yoshiko Kubo, Mika Yamaoka, Ikue Hayashi, Kengo Simon Lord-Dufour, Virginie Bernier, Yves Boie, Jason D. Burch, Patsy Yoshida, Kei Nakachi, Department of Radiobiology/Molecular Epidemiol- Clark, Danielle Denis, Yongxin Han, James R. Mortimer and Marie-Claude ogy, Radiation Effects Research Foundation, Hiroshima, Japan. Mathieu, Merck Frosst Center for Therapeutic Research, Kirkland, QC. PP2-84 PP2-94 Different Tumoral Evolution Induces Increase of Proteolysis-inducing Leucine-rich Diet and Ascorbic Acid Affect the Proteolysis-inducing Factor (PIF) and Alteration of the Proteolytic System Activities in Young Factor Level and the Muscle Antioxidant Stress Response in Tumor- Tumor-bearing Rats. Tatiane Pertile, Maria C.C.Gomes-Marcondes, bearing Rats. TC Marcondes; BLG Cruz; EM Salomão; MCC Gomes-Mar- Department of Physiology and Biophysics, Institute of Biology, State condes, Departament of Physiology and Biophysics, Biology Institute, University of Campinas – Unicamp – 13083-800, Campinas/SP, Brazil. State University of Campinas, Campinas, SP, Brazil. PP2-85 PP2-95 Anti-interleukin-6 Receptor Antibody Prevents T-cell Transfer Colitis Plasma Derived HBSAG Inhibits Toll-like Receptor-2 Ligand Induced not only via Suppression of TH17 Differentiation but also via Suppres- Expression of Interleukin-12 and CD80 in Monocytic Cell Line THP-1. sion of TH1 Proliferation. Fumitaka Terabe, Minoru Fujimoto, Satoshi Chen Zhiao, Cheng Yuming, Hu Yuwen, Yuan Zhenghong, Key Laboratory Serada, Jirou Horino, Tsuyoshi Takahashi, Yoshihito Souma, Yuko Matsu- of Medical Molecular Virology, Ministry of Education and Health Shang- kawa, Teppei Nishikawa, Tomoharu Ohkawara, Barry Ripley, Tadamitsu hai Medical College, Fudan University, Shanghai, China. Kishimoto, and Tetsuji Naka, Laboratory for Immune Signal, National Institute of Biomedical Innovation, Osaka, Japan. PP2-96 Injectable, thermo-reversible and Complex Coacervated Combination PP2-86 Gels Containing IL-1 Receptor Antagonis Inhibits IL-1 BETA-induced Inhibitory Effect of Carpinus Tschonoskii on the Infl ammatory Chemo- MMP-3 Expression in Human Osteoarthritis Chondrocytes. Jae-Bum kines, MDC and TARC, IFN-γ-stimulated HACAT Human Keratinocytes. Jun, Young-In Na, Choong Hyeok Choi, Jang Kyoung Kim and Yong-Hee Gyeoung-jin Kang, Ji-young Moon, Hye-ja Lee, Eun-jin Yang, Sun-soon Kim, Department of Rheumatology, The Hospital for Rheumatic Diseases, Park, Hee-kyoung Kang, Byoung-sam Yoo, and Eun-sook Yoo, Depart- Hanyang University, Seoul, Korea ment of Pharmacology, College of Medicine, Cheju National University, Jeju, South Korea. PP2-97 Estimation of Cytokine Levels and its Ratio for Autoimmune Pathology, PP2-87 Adenoma and Cancer of Thyroid Glands. Sergei P. Kazakov, Nikolai Ev. Effects of Horse Bone Extracts on Induced Postmenopausal Osteoporo- Kushlinsky, Research Scientifi c Center, Burdenko Main Military Clinical sis in Rats. Sun-Soon Park, Weon-Jong Yoon, Hye-Ja Lee, Gyeong-Jin Hospital, DM, Moscow, Russia. Kang, Eun-Jin Yang, Sung-mi Kim, Chang-Su Choo, Hee-Kyoung Kang and Eun-Sook Yoo, Department of Pharmacology, College of Medicine, PP2-98 Cheju National University, Jeju, South Korea. Hyper-induction of COX-2-Mediated Proinfl ammatory Cascade: A Mech- anism for the Pathogenesis of Avian Infl uenza H5N1 Infection. Suki M.Y. PP2-88 Lee, Chung-Yan Cheung, John M. Nicholls, J. S. Malik Peiris, Department Immunomodulatory Production of NO by Cytokines in Algerian Patients of Microbiology, The University of Hong Kong, Hong Kong, China. with Bowel Disesae. Hayet Rafa, Manel Amri, Mourad Belkhelfa, Houria Saoula, Amira F. Boutaleb, Chafi a Touil-Boukoffa, Team: Cytokines and PP2-99 NOSynthase, Laboratory of Cellular and Molecular Biology, Faculty of Induction of Pro-infl ammatory Mediators by H5N1 Infection of Primary Biological Science, USTHB, Algiers, Algeria. Human Lung Microvascular Endothelial Cells. Chung-Yan Cheung, Suki M. Y. Lee, J. S. Malik Peiris, Department of Microbiology, The University PP2-89 of Hong Kong, Hong Kong, China. Suppression of Pro-infl ammatory Cytokines and Mediators Expression by Brown Algae Sargassum micracanthum Extracts in Murine Macro- PP2-100 phage RAW 264.7 Cells. Weon-Jong Yoon, Kil-Nam Kim, Ji-Young Kim, Creation of Mutant TNF with TNF Receptor-1 Selective Antagonistic Hee-Jung Kim, Soo-Yeong Park, Wook Jae Lee, and Chang-Gu Hyun, Activity for the Development of a Novel Autoimune Disease Drug. Jeju Biodiversity Research Institute, Jeju Hi-Tech Industry Development Tetsuya Nomura, Yasuhiro Abe, Yasuo Yoshioka, Hiroko Shibata, Hiroyuki Institute, Jeju, Korea, Department of Pharmacology, College of Medi- Kayamuro, Yohei Mukai, Madoka Taniai, Tsunetaka Ohta, Shinsaku cine, Cheju National University, Jeju , South Korea. Cytokines Montreal 2008 25 Monday, October 13, 2008
Nakagawa, Haruhiko Kamada, Shin-ichi Tsunoda and Yasuo Tsutsumi, Horwitz, Department of Microbiology and Immunology, University of National Institute of Biomedical Innovation (NiBio), Osaka, Japan; British Columbia, Vancouver, BC. Graduate School of Pharmaceutical Sciences, Osaka University, PP2-375 Osaka, Japan. Ingested IFN-Alpha2a Prolongs the ‘Honeymoon’ Phase in New Onset PP2-101 Type 1 Diabetes Mellitus (T1D) in a phase II Randomized clinical The Role of Interferon Regulatory Factor 3 and p38 in Infl uenza A Virus trial (RCT). Kristina I. Rother, Rebecca J. Brown, Miriam M. Morales, Induced Pro-infl ammatory Cytokines. Kenrie P. Hui, Suki M. Lee, Chung- Elizabeth Wright, Zhigang Duan, C. Campbell, David M. Harlan, Philip R. yan Cheung, Iris H. Y. Ng, Leo L. M. Poon, Yi Guan, Nancy Y. Ip, Allan S. Orlander, Staley A. Brod, U. Texas Medical School, Department of Inter- Lau and JS Malik Peiris, Department of Microbiology, Li Ka Shing Faculty nal Medicine and Neurology, Houston, TX, National Institute of Diabetes of Medicine, The University of Hong Kong, Hong Kong, China. and Digestive and Kidney Diseases (NIDDK), Bethesda, MD. PP2-102 PP 3 – CYTOKINES AND CHEMOKINES: MECHANISMS OF ACTION WFDC1/PS20: A Novel Viral Permissivity Factor. Erin Rogers, Ehtesham PP3-115 Baig, Raymond Alvarez, James Reading, Anna Vyakarnam, DanLin Jia S-nitrosylated S100A8– Novel Anti-infl ammatory Properties. Su Yin and John Nicholls and Eleanor Fish, Department of Immunology, Univer- Lim, Mark Raftery, Hong Cai, Shane Thomas, Kenneth Hsu and Carolyn sity of Toronto, Toronto, ON. L. Geczy, Centre for Infection and Infl ammation Research, Bioanalytical PP2-103 Mass Spectrometry Facility and Centre for Vascular Research, School Experimental Assessment of Photodynamic Therapy with 5,10,15,20- of Medical Sciences, University of New South Wales, Sydney, NSW tetrakis- (Methoxyphenyl)-Porphyrins in Rat Walker Tumor. Adriana G. Australia. Filip, Simona V. Clichici, Adriana V. Muresan, Claudia Gherman, Doina PP3-117 Daicoviciu, Rodica M. Ion, Simina Dreve, Nicoleta Decea, Remus Moldo- Unaltered Neurological Disease and Mortality in CXCR3-defi cient Mice van, Department of Physiology, “Iuliu Hatieganu” University of Medicine Infected Intracranially with LCMV-armstrong Strain. Markus J Hofer, and Pharmacy Cluj-Napoca, Romania. Sally L Carter, Marcus Mueller and Iain L Campbell, School of Molecular PP2-104 and Microbial Biosciences and the Bosch Institute, The University of Role for Tumor Necrosis Factor-alpha (TNF-α) in Hearing Loss and in Sydney, NSW, Australia, Department of Neurology, University of Bonn, Aquaporin-4 (AQP-4) Expression. Min Kyo Jung, Song E. Kim, Sang W. Germany. Yeo and Steven K. Juhn, Department of Otolaryngology-HNS, School of PP3-122 Medicine, The Catholic University of Korea, Seoul, Korea. 2’-5’ Oligoadenylate Synthetase Shares Active Site Architecture with PP2-105 the Archaeal CCA Editing Enzyme. Séverine Torralba, Jelena Sojat and Cytokine Evaluation of Seven Different Respiratory Infections. Matthew Rune Hartmann, Centre for Structural Biology, Dept. of Molecular Biol- C. Groll and Peter Bellos, Quansys Biosciences, Logan, UT. Positive ogy, University of Aarhus, Denmark. samples from Infl uenza A, B, Parainfl uenza 1,2,3. PP3-123 PP2-106 Functions of IL-32 in Human Vascular Endothelial Cells. Claudia A. Nold- Strategy for a Robust Preclinical Human Assay to Assess Potential Petry, Marcel F. Nold, Jarod A. Zepp, Alaine K. Walborn, and Charles for Cytokine Release Syndrome with Therapeutic Antibodies. Ram A. Dinarello, Department of Medicine, University of Colorado Health Achuthanandam, Peter J. Bugelski, George Treacy and Renold J. Sciences Center, Denver, Colorado, USA. Capocasale, Toxicology and Investigative Pharmacology, Centocor PP3-124 R&D, Radnor, PA. Differential Responses to Oncostatin-M in C57BL/6 and BALB/C Mice in PP2-108 vivo. Carl D. Richards, Christine Kerr, Dominik K. Fritz, Andrew D. Row- Mouse Model of Eczema Vaccination. Jarmila Zajicova and Zora an2 and Carrie M. Langdon, Centre for Gene Therapeutics, Department Melkova, Institute of Immunology and Microbiology, 1st Medical Faculty, of Pathology and Molecular Medicine, McMaster University, Hamilton, Charles University, Prague, Czech Republic. Ontario, Canada and 2University of Newcastle, Newcastle, UK. PP2-109 PP3-126 Ultra Human Interferons Exhibit Higher Activity than the Standard Interferome: The Database of Interferon Regulated Genes. Shamith Interferons in Prevention of Human Papillomavirus Infection in Cells. Samarajiwa, Sam Forster, Katie Auchett, Paul Hertzog, Center for In- Barbara Schwartz, Kevin Anton, Dolly Koltchev, Michael Skawinski, nate Immunity and Infectious Diseases, Monash Institute of Medical William Clark, Thomas Lavoie, Lara S. Izotova, David Lembo, Patricia Research, Monash University, Clayton, Victoria, Australia. Day, Susana Pang, John T. Schiller and Sidney Pestka, Department of PP3-127 Molecular Genetics, Microbiology, and Immunology, RWJMS-UMDNJ, Cardiotrophin-like Cytokine (CLC) and Epstein-barr Virus Induced Gene Piscataway, NJ. 3 (EBI3) Form A Composite Cytokine. Isabelle Cognet, Sandrine Crabe, PP2-110 Aurélie Tormo, Catherine Guillet, Lydie Canier, Sylvie Chevalier, Greg Role of IL21R in the Pathogenesis of Murine Models of SLE. Leslie Lowe, C.A. Elson, Dominique Couez, Odile Devergne, Hugues Gascan and Heath Guay, Tatyana Andreyeva, Christie Damphousse, Nancy Stedman, Jean-François Gauchat, Département de pharmacologie, Université de Laird Bloom, Stephane Olland, Tom Brown, Cheryl Nickerson-Nutter, Montréal, Montreal, QC. Mary Collins, and Debbie Young, Wyeth Research: Infl ammation and PP3-128 Biological Technologies, Cambridge, MA. Interleukin-6 Acts in the Fashion of a Classical Chemokine on Mono- PP2-111 cytic Cells by Inducing Integrin Activation, Cell Adhesion, Actin Interleukin-6 Regulates the Severity of Chronic Autoimmune Myocardi- Polymerization, Chemotaxis and Trans-migration. Thomas Clahsen, tis Following Coxsackievirus Infection. Maya C. Poffenberger, Nadine Fred Schaper, Department of Biochemistry, RWTH Aachen University, Straka, Nahida El Warry, Dianne Fang, Iryna Shanina and Marc S. Aachen, Germany.
26 Cytokines Montreal 2008 Monday, October 13, 2008
PP3-129 PP3-140 CC Chemokine Receptor 5-dependent Endothelial Progenitor Cell Protective Role of CX3CR1-medicated Signal Pathway in Clostridium Homing to Skin Wound. Yuko Ishida, Akihiko Kimura, Kouji Matsushima, Diffi cile Toxin A-induced Enteritis. Masanori Inui, Yuko Ishida, Akihiko Naofumi Mukaida, Toshikazu Kondo, Department of Forensic Medicine, Kimura, Naofumi Mukaida, Toshikazu Kondo, Department of Molecular Wakayama Medical University, Wakayama, Japan. Immunology, Institute of Advanced Medicine, Wakayama Medical Uni- versity, Wakayama, Japan. PP3-130 STAT3 is a Negative Regulator of Type I IFN-induced Antiviral Respons- PP3-141 es. Wei-Bei Wang and Chien-Kuo Lee, Graduate Institute of Immunol- Dissecting Interactions Between Interleukin-1 Alpha Histone Acet- ogy, National Taiwan University, Taipei, Taiwan. yltransferase Complexes. Blanka Vicenova, Miroslava Buryskova, Ladislav Burysek, Martin Pospisek, Dept. of Genetics and Microbiology, PP3-131 Faculty of Science, Charles University in Prague, Czech Republic. Cytokine Responses of Naïve T-cells Requires Special Permission by Accessory Cells. Noriko Sato, Thomas A. Waldmann, Yutaka Tagaya, PP3-142 Metabolism Branch, National Cancer Institute, NIH, Bethesda, MD. HSP70 Dependent Zinc Protection Against TNF-induced Lethal Infl am- mation Allows for a Safer Antitumor Therapy. Filip Van Hauwermeiren, PP3-132 Claude Libert, Department for Molecular Biomedical Research, VIB; Oncostatin M Induces Interleukin 17 Receptor A and Synergistic Re- Ghent, Belgium. sponses to Interleukin-17 in Mouse Aortic Adventitial Fibroblasts. Matt Scott, Jackie Beitz, Bernardo Trigatti and Carl D. Richards, Centre for PP3-143 Gene Therapeutics, Department of Pathology and Molecular Medicine, MARCH1 E3 Ubiquitin Ligase in Pro-infl ammatory Cytokine Response: McMaster University, Hamilton, ON. What is its Role in Infl ammation Regulation? Jessy Tremblay, Marie- Claude Bourgeoie-Daigneault, Jacques Thibodeau, Gabrielle Huppé, PP3-133 Viktor Steimle, Département de Microbiologie et Immunologie, Univer- Combination of Interferon-gamma and Transforming Growth Factor-beta sité de Montréal, Montréal, QC. (TGF-beta) Results in an Altered Gene Expression Profi le. Milton W. Taylor, Oman N.Ozes, Takuma Tsukahara, Lawrence Blatt, Department of PP3-144 Biology, Indiana University, Bloomington and InterMune, Brisbane, CA. Molecular Mechanisms of MHC Class II Inhibition by the MARCH1 Ubiquitin Ligase in Response to IL-10. Marie-Claude Bourgeois- PP3-134 Daigneault, Gabrielle Huppé, Jessy Tremblay, Viktor Steimle, and Neutralizing Monoclonal Antibodies Against Type I Interferon can Jacques Thibodeau, Department of Microbiology and Immunology, Trigger an “Interferon-like” Response: Involvement of the Fc Domain. University of Montreal, QC. Herwig P. Moll, Harald Freudenthaler, Anna Zommer, Elisabeth Buch- berger, Christine Brostjan, Department of Surgery – Research Laborato- PP3-145 ries, Medical University of Vienna, Austria. IL-33 is a Potent Activator of Human Eosinophils. Michael R. Comeau, Bo-Rin Park Yoon, Heidi K. Jessup, Penny Anders, Dave Swart, Molly D. PP3-135 Smithgall and Dirk E. Smith, Infl ammation Research, Amgen, Inc. Seattle, Resveratrol Inhibits Foam Cell Formation via NADPH Oxidase 1-Medi- WA. ated ROS and MCP-1. Kheewoong Baek, Dae-Weon Park, Sung-Chul Park, Yoon-Ki Park, Jae-Ryong Kim, Suk-Hwan Baek, Aging-associated PP3-146 Vascular Disease Research Center, Department of Biochemistry & A GMCSF and CCL2 Fusion Chimera Induces Apoptosis in CCR2 Ex- Molecular Biology, College of Medicine, Yeungnam University, Daegu, pressing Lymphomyeloid Cells and Promotes Xenotolerance. Moutih South Korea. Rafei, Yamina Berchiche, Jian Hui Wu, Elena Birman, Nikolaus Heveker, and Jacques Galipeau, The Montreal Center for Experimental Therapeu- PP3-136 tics in Cancer, Montreal, QC. Ca2+-Independent Phospholipase A2 Participates in Toll-Like Receptor 4-Induced MCP-1 Release. Sun-Hye Lee, Eun-Jung Lim, Jae-Ryong Kim, PP3-147 Suk-Hwan Baek, Aging-associated Vascular Disease Research Center, Lymphotoxin-α β Heterotrimers are Shed from the Surface of Activated Department of Biochemistry & Molecular Biology, College of Medicine, Human Lymphocytes and Circulate in Human Serum. Judy Young, Allen Yeungnam University, Daegu, South Korea. Nguyen, Xin Yu, Eugene Chiang, Racquel Corpuz, JianPing Yin, Catherine Kung, Richard Vandlen, Dan Yansura, Laura DeForge, Wai Lee Wong, PP3-137 Jane Grogan, Department of Assay and Automation Technology, Genen- Specifi c Determination of Human IFN-α8: Establishment of the Sub- tech Inc., South San Francisco, CA. tupe-specifi c Monoclonal Antibodies and Elisa Systems. Chie Ushio, Harumi Ariyasu, Tohru Kayano, Hitomi Ohta, Miho Aga, Toshio Ariyasu, Tsunetaka Ohta and Shigeharu Fukuda, Biomedical Institute, Research 20:00 EVENING AT NOTRE DAME BASILICA OF MONTREAL Center, Hayashibara Biochemical Laboratories, Inc., Okayama, Japan. PP3-138 Molecular Mechanisms of Interleukin-27-induced Cytokine Production in Human Monocytic Cells. Christina Guzzo, Nor Fazila Binti Che Mat and Katrina Gee, Department of Microbiology and Immunology, Queen’s University, Kingston, ON. PP3-139 The Absence of IL-6/STAT3 Signals Enhanced Arsenite-induced Renal Injury by Promoting Autophagy of Tubular Epithelial Cells with Aber- rant ERK Activation. Akihiko Kimura, Yuko Ishida, Naofumi Mukaida and Toshikazu Kondo, Department of Forensic Medicine, Wakayama Medical University, Wakayama, Japan.
Cytokines Montreal 2008 27 Tuesday, October 14, 2008
PLENARY SESSION 2 LE GRAND SALON
INFLAMMATION AND CANCER
Chairpersons: Giorgio Trinchieri, National Cancer Institute, (USA) Maya Saleh, McGill University (Canada) 08:30 PL2-8 Molecular Pathways Linking Infl ammation and Cancer. Alberto Mantovani, Istituto Clinico Humanitas IRCCS, University of Milan, Milan, Italy. 09:00 PL2-9 Toll-like Receptors in Oncogenesis. Ruslan Medzhitov, Department of Immunology, Yale University School of Medicine, New Haven, CT. 09:30 PL2-10 Induction of Innate Immune Responses Through Nalp3 Infl ammasome Sensing of Asbestos and Silica. Jurg Tschopp, Department of Biochemistry, University of Lausanne, Epalinges, Switzerland. 10:00 PL2-11 Role of Infl ammatory Caspases in Mucosal Immunity, Colitis and Colorectal Cancer. Maya Saleh, Department of Medicine, McGill University, Montreal, QC.
10:30 COFFEE BREAK – FOYER
11:00 PL2-12 IL-7 Paralyses Inhibitory Networks, Potently Boosts Autoimmunity and Viral vaccine Induced Tumor Immune Rejection. Thomas Calzascia*, Marc Pellegrini*, Albert Lin, Kristine M Garza, Alisha R Elford, Arda Shahinian, Pamela S Ohashi & Tak W Mak, University Health Network, University of Toronto, Princess Margaret Hospital, Toronto, Canada. 11:30 PL2-13 Diverse Roles of STAT3 Signaling in Cancer. Hua Yu and Richard Jove, Tumor Immunology and Molecular Medicine, Beckman Research Institute, City of Hope Cancer Center, Duarte, CA. 12:00 PL2-14 The Mechanism of Interferon Gene Transcription in Dendritic Cells. Keiko Ozato, Prafullakumar Tailor, Lakshimi Ramakrishna, Tsung Hsien Chang, Toru Kubota, Mayumi Matsuoka and Herbert Morse, C., Program in Genomics of Differentiation, NICHD, National Institutes of Health, Bethesda, MD.
12:30 LUNCH BREAK – ON YOUR OWN
28 Cytokines Montreal 2008 Tuesday, October 14, 2008
WORKSHOP 5 MARQUETTE WORKSHOP 6 LE GRAND SALON GENE REGULATION: TRANSCRIPTIONAL AND CONTROL OF CELL GROWTH AND DEATH IN CANCER POST-TRANSCRIPTIONAL MECHANISMS AND HEMATOPOIESIS Chairpersons: Tom Hamilton, Cleveland Clinic (USA) Chairpersons: Michele Barry, University of Alberta (Canada) Raymond Kaempfer, Hebrew University (Israel) Nancy Reich, Stony Brook University (USA) 14:00 WO5-170 14:00 WO6-195 IL-17 Uses a Distinct Signaling Pathway to Prolong Chemokine NF-κB Signaling is Essential in Lung Adenocarcinoma. Etienne mRNA Half-life. Justin Hartupee, Shyamasree Datta, Michael Meylan, Alison Dooley, Erin Turk and Tyler Jacks, Koch Institute Novotny, Dongxu Sun, Paul Pavicic, and Thomas Hamilton, for Integrative Cancer Research, Massachusetts Institute of Department of Immunology, Lerner Research Institute, Cleveland Technology, Cambridge, MA. Clinic Foundation, Cleveland, OH. 14:15 WO6-196 14:15 WO5-171 Defi ciency of the Soluble Pattern Recognition Receptor The Suppressor of Cytokine Signaling 1, a New Link Between Pentraxin-3 Increases Susceptibility to Tumor Growth and p53, DNA Damage and Senescence. Viviane Calabrese, Metastasis. Virginia Maina, Andrea Doni, Cecilia Garlanda and Frédérick A. Mallette, Xavier Deschênes-Simard, Sheela Alberto Mantovani, Laboratory of Immunology and Infl ammation, Ramanathan, Julien Gagnon, Adrian Moores, Subburaj Ilangu- Istituto Clinico Humanitas, Rozzano, Milan, Italy. maran and Gerardo Ferbeyre, Department of Biochemistry, 14:30 WO6-197 Faculty of Medicine, University of Montreal, Montreal, QC. The Antiapoptotic Protein G1P3 (ISG 6-16) in Survival Signaling (also PP5-171) in Breast Carcinoma: Cytokine and Endocrine Cross Talk. 14:30 WO5-172 Venugopalan Cheriyath, Barbara S. Jacobs, Dustin G. Thomas, Regulation of TNFα Gene Transcription at the Post-initiation Perry Evangelista and Ernest C. Borden, Taussig Cancer Institute, Step. Megan A. Kennedy, Sergei Nechaev, Daniel A. Gilchrist, Center for Hematology and Oncology Molecular Therapeutics, Ginger W. Muse, Yurii Chinenov, Karen Adelman and Inez Cleveland Clinic, Cleveland, OH. Rogatsky, Hospital for Special Surgery and Dept. of Microbiology 14:45 WO6-198 and Immunology, Weill Medical College of Cornell University, Activated NOTCH2 Links Protein Kinase C Delta (PKC-δ) to the New York, NY. Expression of CD23 in Chronic Lymphocytic Leukemia (CLL) 14:45 WO5-173 Cells. Josef D. Schwarzmeier, Rainer Hubmann, Martin Hilgarth, ssRNA Viruses Inactivate P53 and Induce Noxa-dependent Susanne Schnab, Dita Demirtas, Katrina Vanura, Trang Le, Apoptosis via Post-Translational Modifi cations of IRF-1, IRF-3 Ulrich Jäger and Medhat Shehata, Clinic of Internal Medicine I, and CREB. C. Lallemand, B. Blanchard, P. Lebon, E. May and Department of Hematology and Hemostaseology, Medical M.G. Tovey, Laboratory of Viral Oncology, FRE2937 CNRS, Institut University of Vienna, Vienna, Austria. André Lwoff, Villejuif, France. 15:00 WO6-199 15:00 WO5-174 Targeting the Apoptotic Pathway with BCL-2 Inhibitors IRAK2 is Critical for LPS-mediated Post-transcriptional Control. Sensitizes Primary Chronic Lymphocytic Leukemia to VSV- Hui Xiao, Youzhong Wan, Tae Whan Kim, Katarzyna Bulek, Sujan induced Oncolysis. Vanessa F. Tumilasci, Stephanie Oliere, Chaudhuri, Barsanjit Mazumder, George R Stark, James Thomas, John Bell and John Hiscott, Lady Davis Institute - Jewish Xiaoxia Li, Department of Immunology, Cleveland Clinic Founda- General Hospital, McGill University, Montreal, QC. tion, Cleveland, OH. 15:15 WO6-200 15:15 WO5-175 IL-9 Inhibits Corticoid-induced Expression of the BH3-only Opposite Transcriptional Effects of Interferon Regulatory Protein BMF in Mouse Thymic Lymphomas Via the JAK-STAT Factor 3 on Differential Human Interferon-A Gene Expresssion. Pathway. Amel Tounsi and Jean-Christophe Renauld, Ludwig Pierre Génin, Rongtuan Lin, John Hiscott and Ahmet Civas, UPR Institute for Cancer Research, Brussels, Belgium. 2228 - CNRS, Laboratoire de Régulation Transcriptionnelle et 15:30 WO6-201 Maladies Génétiques, UFR Biomédicale des Saints-Pères, The Lnk Adaptor Protein Negatively Regulates Specifi c SCF Université Paris Descartes, Paris, France. Biological Responses in Primary Hematopoietic Cells. Clotilde 15:30 WO5-176 Simon, Elisabetta Dondi, Amandine Chaix, Paulo de Sepulveda, Identifi cation of a Novel Enhancer Region in the Distal Promoter Terrance J. Kubiseski, Nadine Varin-Blank and Laura Velazquez, Region of the Human Interferon-Lambda1 Gene. Scott J.P. Institut Cochin, Université Paris Descartes, CNRS, Paris, France. Thomson, FuiGoon Goh, Helen Banks, Brian Foxwell, Sergei V. 15:45 WO6-202 Kotenko and Irina A. Udalova, Kennedy Institute of Rheumatol- Interferon Regulatory Factors 4 is Involved in Epstein-Barr ogy, Imperial College, London, UK. Virus-mediated Transformation of Human B Lymphocytes. 15:45 WO5-177 Dongsheng Xu, Lingjun Zhao, Luis Del Valle, Judith Miklossy, Multiple Intracellular Signaling Pathways Contribute to and Luwen Zhang, Nebraska Center for Virology, School of Synergistic TLR Ligand-induced Cytokine Gene Expression Biological Sciences, University of Nebraska, Lincoln, NE. in Human Monocyte-derived Dendritic Cells. Sanna Mäkelä, 16:00 COFFEE BREAK – FOYER Mari Strengell, Taija Pietilä, Pamela Österlund and Ilkka Julkunen, Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland. 16:00 COFFEE BREAK – FOYER
Cytokines Montreal 2008 29 Tuesday, October 14, 2008
WORKSHOP 7 DULUTH WORKSHOP 8 JOLLIET STRUCTURE AND FUNCTION OF CYTOKINES AND THEIR RECEPTORS PATHOGEN EVASION OF THE HOST CYTOKINE RESPONSE Chairpersons: Paul Hertzog, Monash University (Australia) Chairpersons: Michael Gale Jr., University of Washington (USA) John Sims, AMGEN (USA) Karen Mossman, McMaster University (Canada) 14:00 WO7-217 14:00 WO8-248 Identifi cation of Functional Roles for both IL-17RB and IL-17RA Ebola Virus Protein VP35 Inhibits Activation of the Interferon- in Mediating IL-25 Induced Activities. Erika A. Rickel, Lori A. inducible Kinase PKR by RNA. Maayan Eitan, Farhat Osman, Siegel, Bo-Rin P. Yoon, James Rottman, David Kugler, David Lise Sarah Namer, Einav Eliahu, Yona Banai, Raymond Kaempfer, Swart, Penny Anders, Joel E. Tocker, Michael R. Comeau, and Department of Molecular Virology, Faculty of Medicine, Alison L. Budelsky, Department of Infl ammation Research, The Hebrew University of Jerusalem, Israel. Amgen, Seattle, WA. 14:15 WO8-237 14:15 WO7-218 Reovirus Inhibits Interferon Signaling Through a Novel Mechanism of TOLL/IL-1 Receptor Domain Dimerization and Mechanism Involving Nuclear Accumulation of IRF9. Barbara Signaling Revealed by the Crystal Structure of MYD88. Greg Sherry, Jennifer Zurney, Takeshi Kobayashi, Geoffrey H. Holm, A. Snyder, Jiansheng Jiang and Tsan Xiao, Laboratory of and Terence S. Dermody, Departments of Molecular Biomedical Immunology, National Institute of Allergy and Infectious Sciences and Microbiology, North Carolina State University, NC. Diseases, National Institutes of Health, Bethesda, MD. 14:30 WO8-238 14:30 WO7-219 Innate immune response triggered by infl uenza A virus is Regulation of Myelopoiesis Through Syntenin-mediated negatively regulated by suppressor of cytokine signaling Modulation of IL-5 Receptor Output. Jeffrey M. Beekman, (SOCS)1 and SOCS3 through a RIG-I/IFNAR1-dependent path- Liesbeth P. Verhagen, Niels Geijsen and Paul J. Coffer, Molecular way. Julien Pothlichet, Michel Chignard, and Mustapha Si-Tahar, Immunology Lab, Dept of Immunology, Dept. of Pediatric Unité Défense Innée et Infl ammation, Institut Pasteur, Paris, Immunology, University Medical Centre Utrecht, Utrecht, France. The Netherlands. 14:45 WO8-239 14:45 WO7-220 PML is Cleaved and Degraded in EMCV-infected Cells. Bouchra Antiviral Potency of Interferon Lambda and Identifi cation of M’chichi, Tarik Regad, Laurent Dianoux, Yann Percherancier Amino Acids that are Important for the Antiviral Activity of and Mounira Chelbi-Alix, CNRS FRE 2937, Institut André Lwoff, Interferon Lambda II. Hans Henrik Gad, Christoffer Dellgren, Villejuif, France. Ole J Hamming, Susanne Vends & Rune Hartmann, Centre for 15:00 WO8-240 Structural Biology, Department of Molecular Biology, University Identifi cation of Non-assigned, Non-homologous Virus Genes of Aarhus, Århus C, Denmark. Inhibiting Interferon Responses. Correia S, Reis AL, Leitão A, 15:00 WO7-221 Goodbourn S, Parkhouse RME, Instituto Gulbenkian de Ciência, Structure-function Characterization of Type I Interferon Oeiras, Portugal. Receptor Signaling Regulation. Nicole A de Weerd, Rebecca 15:15 WO8-241 Piganis, Leyla Zaker-Tabrizi, Hugh Reid, Jennifer Fenner, Susie Regulation of mRNA Processing Genes and Post-initiation Noppert, Jodee Gould, Bernadette Scott, Jamie Rossjohn, W Regulation of Transcription by M. Tuberculosis and by IFNγ Zhao, C Lee, C Plumlee, Christian Schindler, Paul J Hertzog, Stimulation After Infection. Richard Pine, Yaming Qiao, Jeff Centre for Innate Immunity and Infectious Disease, and Cheng, and Antony Canova, Public Health Research Institute, Department of Biochemistry and Molecular Biology, Monash University of Medicine and Dentistry of New Jersey - New University, Clayton, Victoria, Australia. Jersey Medical School, Newark, NJ. 15:15 WO7-222 15:30 WO8-242 Forced Dimerization of gp130-receptor Homo and Heterodimers SHP-1-mediated IRAK-1 Inactivation Inhibits LPS-induced Leads to Constitutive Activation and Cytokine Independent Macrophage Functions During Leishmaniasis. Issa Abu Dayyeh, Growth. J. Suthaus, A. Tillmann, C. Stuhlmann-Laeisz, I. Benoit Cousineau, and Martin Olivier, Department of Micro- Lorenzen, S. Rose-John and J. Scheller, Department of Bio- biology and Immunology, McGill University, Montréal, QC. chemistry, Christian-Albrechts-Universität, Kiel, Germany. 15:45 WO8-243 15:30 WO7-223 T-cell Responses in Heliobacter-induced Gastric Preneo- IL-22R, IL-10R2 and IL-22BP Binding Sites are Topologically plastic Pathology. Ayca Sayi, Esther Kohler, Iris Hitzler and Juxtaposed on Adjacent and Overlapping Surfaces of IL-22. Anne Mueller, Institute of Molecular Cancer Research, Faculty Paul W. Wu, Jing Li, Sreekumar R. Kodangattil, Deborah P. of Medicine, University of Zurich, Zurich, Switzerland. Luxenberg, Frann Bennett, Margot Martino, Mary Collins, Kyriaki Dunussi-Joannopoulos, Davinder S. Gill, Neil M. Wolfman, 16:00 COFFEE BREAK – FOYER Lynette A. Fouser, Wyeth Research-Infl ammation, Cambridge, MA. 15:45 WO7-224 The Role of TRAF2 Binding to the Type I IFN Receptor in Alterna- tive NFκB Activation and Antiviral Response. Chuan He Yang, Aruna Murti, Susan R. Pfeffer, Meiyun Fan, Ziyun Du & Lawrence M. Pfeffer. Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN. 16:00 COFFEE BREAK – FOYER
30 Cytokines Montreal 2008 Tuesday, October 14, 2008
SYMPOSIUM 3 LE GRAND SALON
microRNA REGULATION OF CYTOKINE GENE EXPRESSION
Chairpersons: Bryan Williams, Monash Institute for Medical Research (Australia) Robert Silverman, Cleveland Clinic (USA) 16:30 SY3-9 Stimulation of Innate Immunity by Short Interfering and micro RNAs. Bryan RG Williams, Michael P Gantier, Stephen Tong, Dakang Xu, and Anthony J Sadler, Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia. 17:00 SY3-10 Role of the miR-200 Family in Mediating EMT in Response to TGF-β. Philip A. Gregory, Cameron P. Bracken, Andrew G. Bert, Emily L. Paterson, Natasha Kolesnikoff, Gelareh Farshid, Yeesim Khew-Goodall and Gregory J. Goodall, Hanson Institute, Institute of Medical and Veterinary Science, Adelaide, Australia. 17:20 SY3-11 Role of Small RNAs Generated by RNase L in Antiviral Innate Immunity. Robert H. Silverman, Beihua Dong, Michael Gale, and Krishnamurthy Malathi, Department of Cancer Biology, Cleveland Clinic, Cleveland, OH. 17:40 SY3-12 The Role of miRNAs in the Regulation of Interferon-gamma Gene Expression. Ram Savan, Rajesh Yalamanchili, Shakeeb Hakim and Howard A. Young, Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, Frederick, MD.
SYMPOSIUM 4 MARQUETTE / JOLLIET
BIOLOGY AND REGULATION OF TH17 CELLS AND IL17
Chairpersons: Sarah Gaffen, SUNY-Buffalo (USA) John O’Shea, NIH (USA) 16:30 SY4-13 Structure and Function of the IL-17 Receptor. Sarah L. Gaffen, Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA. 17:00 SY4-14 Cytokine Regulation of Th17 and Tfh Cell Differentiation. Chen Dong, Department of Immunology, MD Anderson Cancer Center, Houston, TX. 17:20 SY4-15 Role of IL-17 and Related Cytokines in Experimental Erosive Arthritis. Wim B van den Berg, Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. 17:40 SY4-16 The Critical Role of Epithelial-derived Act1 in IL-17- and IL-25-mediated Pulmonary Infl ammation. Shadi Swaidani, Katarzyna Bulek, Zizhen Kang, Caini Liu, Yi Lu, Mark Aronica, Xiaoxia Li, Department of Immunology, Cleveland Clinic, Cleveland, OH. 18:00 SY4-17 Cytokine Signaling and T-cell Differentiation. John O’Shea, National Institutes of Health, Bethesda, MD.
Cytokines Montreal 2008 31 Tuesday, October 14, 2008
POSTER DISCUSSION 2 18:00 – 19:30 HOCHELAGA 2 Fitting, Jean-Marc Cavaillon, Institut Pasteur, 28 rue Dr. Roux, 75015 Paris, France. 18:15 PD2-247 PP4-159 A Vaccinia Virus Deletion Mutant Reveals Additional Inhibitors Aryl Hyrdocarbon Receptor Participates in TH17 Cell Differentiation of NFκB. Katharine Fagan, Brianne Couturier, Nick van Buuren, Through Negatively Regulating STAT1 Activation. Akihiro Kimura, Tet- Crystal Harmon, Joanna Shisler and Michele Barry, Department suji Naka and Tadamitsu Kishimoto, Laboratory of Immune Regulation, of Medical Microbiology and Immunology, University of Alberta, Graduate School of Frontier Biosciences, Suita city, Osaka, Japan. Edmonton, Alberta, Canada; Department of Microbiology, University of Illinois, Urbana, IL. PP4-160 A Transient Breach in the Epithelial Barrier Leads to Regulatory T-Cell 18:30 PD2-244 Generation and Resistance to TNBS-Colitis Induction. Monica Boirivant, HIV-1 Antagonizes Innate Antiviral Signaling Pathways by Antonello Amendola, Alessia Butera, Massimo Sanchez, Lili Xu, Mar- Targeting Interferon Regulatory Factor-3 (IRF-3). Brian Doehle iarosaria Marinaro, Atsushi Kitani, Claudia Di Giacinto, Warren Strober, and Michael Gale Jr., Department of Immunology, University of Ivan J. Fuss, Mucosal Immunity Section, Laboratory of Host Defenses, Washington, Seattle, WA. National Institute of Allergy and Infectious Diseases, Bethesda, MD. 18:45 PD2-259 PP4-161 Antagonism of the Innate Immune Response by Human The Role of Lymphotoxin-beta-receptor Signaling in Dendritic Cell Rhinovirus 1a. Jennifer Drahos and Vincent Racaniello, Function. Leslie Summers deLuca, Yunfei Gao, Douglas D. McCarthy, Department of Microbiology, Columbia University, New York, NY. Lesley Ward, and Jennifer L. Gommerman, Department of Immunology, 19:00 PD2-225 University of Toronto, Toronto, ON. Biological Activities and Detection of Cynomolgus Interferon-α PP4-162 Subtypes. Doranelly H. Koltchev, Michael Skawinski, Diane Vy, Methyl Dehydro-jasmonate(J2) Expression Supresses the Production Xiao-Hong Lin, Sara Crisafulli, Karlene Moolchan, Lara Izotova, of Infl ammatory Mediators by Down-regulating NF-ΚB, JNK STAT1 Ex- Edward Dolphin, Thomas B. Lavoie, William Clark, Ronald G. pression. Hye-Ja Lee, Hung-The Dang, Eun-Jin Yang, Weon-Jong Yoon, Jubin and Sidney Pestka, PBL InterferonSource, Piscataway, NJ. Gyeoung-Jin Kang, Sun-Soon Park, Hee-Kyoung Kang, Jee H. Jung, and 19:15 PD2-227 Eun-Sook Yoo, Department of Pharmacology, College of Medicine, Cheju Design of High Affi nity Interleukin-6 and gp130 Variants: National University, Jeju, South Korea. Implications for Cytokine-receptor Assembly. Nina Adam, PP4-163 Stephanie Tenhumberg, Georg H. Waetzig, Athena Chalaris, Regulation of IL-4R Signaling in TH17 Cells. Laura A. Tesmer, Sujata Björn Rabe, Jan Suthaus, Dirk Seegert, Jürgen Scheller, Stefan Sarkar, David A. Fox, Division of Rheumatology, Department of Internal Rose-John and Joachim Grötzinger, Institute of Biochemistry, Medicine, University of Michigan, Ann Arbor, MI. Christian-Albrechts-University, Kiel, Germany. PP4-164 HOCHELAGA 2-6 Relationship Between Regulatory T-cell Infi ltration and Progression POSTER SESSION 2 18:00 – 19:30 & MARQUETTE of Different Tumors Assessed by High-density Tissue Microarray. PP 4 – IMMUNE CELL ACTIVATION AND FUNCTION Kazuya Nagano, Tomoaki Yoshikawa, Toshiki Sugita, Hiromi Nabeshi, PP4-150 Sunao Imai, Kensuke Suzuki, Junya Fukuoka, Shinsaku Nakagawa, Signaling Via LTbR & HVEM-BTLA Pathways Control Dendritic Cell Yasuhiro Abe, Haruhiko Kamada, Shin-ichi Tsunoda, and Yasuo Tsutsumi, Homeostasis. Carl De Trez, Kirsten Schneider, Sukwon Ha, Chris A. Laboratory of Pharmaceutical Proteomics, National Institute of Biomedi- Benedict, Carl F. Ware, Laboratory of Parasitology, Université Libre de cal Innovation; Graduate School of Pharmaceutical Sciences, Osaka Bruxelles, Brussels, Belgium; Division of Molecular Immunology, University, Osaka, Japan. La Jolla Institute for Allergy and Immunology, La Jolla, CA, USA. PP4-165 α PP4-153 Higher effi cacy of Peg-IFN- 2 ribavirin combined therapy in HCV-in- A Novel Antigen Presenting Cell Population (VAP) Modulates Type 2 fected patients with functional myeloid dendritic cells (MDC). Ian Gaël Immunity Against Infl uenza Virus Infection. Jae-Kwang Yoo, Carole Rodrigue-Gervais, Hawley Rigsby, Bernard Willems and Daniel Lamarre, Galligan, Daniel Burke, Eleanor N. Fish, Toronto General Research Centre Hospitalier de l’Université de Montréal; INSERM Unité 743, Institute, University Health Network, Toronto, Ontario, Canada. Hôpital Saint-Luc, Montréal, Québec, Canada; Département de Microbi- ologie-Immunologie, Université de Montréal, Montréal, QC. PP4-155 The Immunomodulatory CD300A Receptor is Differentially Expressed PP4-166 κ on Human TH1 AND TH17 Cells. Francisco Borrego, Sriram Narayanan, p50 NF- B Overexpression in Tumor Associated Macrophages Inhibits Xiaobin Tang, Yelina Alvarez and John E. Coligan, Receptor Cell Biology M1 Infl ammatory Responses and Antitumor Resistance. Chiara Porta, Section, Laboratory of Immunogenetics, National Institute of Allergy and Monica Rimoldi, Alberto Mantovani, Antonio Sica, Fondazione Humani- Infectious Diseases, NIH, Rockville, MD. tas per la Ricerca, Rozzano, Italy. PP4-156 PP4-167 Lung Immune Semaphorins and their Receptors. Elizabeth Smith, Elite Controllers are Enriched with HIV-Specifi c Cells Expressing CD160 Michael M. Lipsky, Louis J. DeTolla, Jr., Jack A. Elias, Achsah D. Keegan, But Lacking PD1. Yoav Peretz, Yu Shi, Zhong He, Lydie Trautmann, Bader Svetlana P. Chapoval, Center for Vascular and Infl ammatory Diseases, Yassine Diab, Elias Haddad and Rafi ck-Pierre Sékaly, Department of Mi- Department of Microbiology and Immunology, University of Maryland crobiology and Immunology, University of Montreal (CHUM). Montréal, QC. School of Medicine, Baltimore, MD. PP4-168 PP4-157 Characterization of the Potential Cross-talk Between Human Phago- Pulmonary Cytokine Microenvironment Prevents Alveolar Macro- cytes and TH17 Cells. Martin Pelletier and Marco A. Cassatella, Depart- phages to Display Endotoxin Tolerance. Francois Philippart, Catherine ment of Pathology, Section of General Pathology, University of Verona, Verona, Italy. 32 Cytokines Montreal 2008 Tuesday, October 14, 2008
PP4-169 PP5-187 Gene-Silencing of Reversion-induced LIM Protein Compromises Glucocorticoid Regulation of the Type I Interferon-JAK/STAT Signaling Responses to Interleukin-16 in Jurkat T-cells. Mark Lee, Dannon Martin, Pathway. Jamie R. Flammer, Megan A. Kennedy, Yurii Chinenov, Lionel Tiffany King, Biology Department of Spelman College, Atlanta, GA. B. Ivashkiv and Inez Rogatsky, Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sci- PP 5 – GENE REGULATION: TRANSCRIPTIONAL AND ences, New York, NY USA; Hospital for Special Surgery, New York, NY. POST-TRANSCRIPTIONAL MECHANISMS PP5-188 PP5-171 The Suppressor of Cytokine Signaling 1, a New Link Between p53, DNA Synergistic Up-regulation of Cytokine Encoding Genes by CpG Oli- Lev Petrenko, Sven Klaschik, Hidekazu Damage and Senescence. Viviane Calabrese, Frédérick A. Mallette, gonucleotides Plus Poly (I:C). Xavier Deschênes-Simard, Sheela Ramanathan, Julien Gagnon, Adrian Shirota, and Dennis M. Klinman, Laboratory of Experimental Immunol- Moores, Subburaj Ilangumaran and Gerardo Ferbeyre, Department of ogy, National Cancer Institute, NIH, Frederick, MD. Biochemistry, Faculty of Medicine, University of Montreal, Montreal, QC. PP5-189 PP5-178 Protein Kinase R-dependent Regulation of c-JUN and EGR-1 in Re- Arindam Chakrabarti, Robert H. Silver- Changes in Gene Expression induced by Pegintron Plus Ribavirin in sponse to Double-stranded RNA. man, and Bryan R. G. Williams, Department of Cancer Biology, Lerner PBMC of Hepatitis C Patients During the First 10 Weeks of Treatment. Milton W. Taylor, Takuma Tsukahara, Jeanette N. McClintick, Howard J. Research Institute, The Cleveland Clinic, Cleveland, OH. Edenberg, Paul Kwo, Department of Biology, Indiana University, Bloom- PP5-190 ington, IN. IRF-1 is Required for Full NF-κB Transcriptional Activity at the HIV-1 Marco Sgarbanti, Anna L. Remoli, Giulia Marsili, Edvige PP5-179 LTR Enhancer. Perrotti, Roberto Orsatti, Ramona Ilari, Emilia Stellacci, Barbara Ridolfi , A Central Role for C/EBP-β (NF-IL6) in Regulating the Expression of Alessandra Borsetti, Leonardo Sernicola, Barbara Ensoli, and Angela Metastasis Associated Gene DAPK1 in a Novel IFN-induced Growth Battistini, Department of Infectious, Parasitic and Immune-Mediated Suppressive Pathway. Sanjit K. Roy, Hui Li, Shreeram C. Nallar and Dhan V. Kalvakolanu, Department of Microbiology & Immunology, University of Diseases, Istituto Superiore di Sanità, Rome, Italy. Maryland School of Medicine, Baltimore, MD 21201, USA. PP5-191 PP5-180 Differential Regulation of the OASL and OAS1 Genes in Response to Viral Jesper Melchjorsen, Helle Kristiansen, Rune Christiansen, Recruitment of Stat1 to Chromatin is Required for Interferon-induced Infection. Johanna Rintahaka, Sampsa Matikainen, Søren R. Paludan and Rune Serine Phosphorylation of Stat1 Transactivation Domain. Iwona Sadzak, Melanie Schiff, Edward Yang, Barbara Schaljo and Pavel Kovarik, Max F. Hartmann, Department of Molecular Biology, University of Aarhus, Perutz, Laboratories, University of Vienna, Vienna, Austria, Laboratory of Denmark. Molecular Cell Biology, Rockefeller University, New York NY. PP5-192 PP5-181 Micro RNA Induction by Interferon alpha and their Potential Role to Fredy Siegrist and Ulrich Role of Interferon-inducible Adenosine Deaminase that Acts on RNA Interfere in the Negative Feedback Pathway. Certa, RNAi Safety, F, Hoffmann-La Roche LTD, Basel, Switzerland. 1 in the Inhibition of the Protein Kinase R Activation During HIV-1 Infection. Guerline Clerzius, Jean-François Gélinas, Aïcha Daher, Eliane PP5-193 Meurs, Anne Gatignol, Lady Davis Institute-Jewish General Hospital, IFN Mediated Inactivation of the 4E-BP1 Repressor of mRNA Transla- McGill University, Montréal,Canada. tion Infl uences an Antiviral Response. Daniel Burke, Nahum Sonenberg, Leonidas C. Platanias, Eleanor N. Fish, Toronto General Research Inst. & PP5-182 University of Toronto, Toronto, ON. Differential Involvement of IRF Members in IL-27 Synthesis Induced by TLR Ligation. Céline Molle, Véronique Flamand, Fabienne Willems, PP5-194 Michel Goldman and Stanislas Goriely, Institute for Medical Immunology NADPH Oxidase Involvement in Regulation of Interleukin-8 mRNA Sta- (IMI), Université Libre de Bruxelles, Charleroi, Belgium. bility in Lipopolysaccharide Treated Endothelial Cells. Imad Al Ghouleh, Alexandra Triantafi llopoulos, Sheldon Magder, McGill University, Critical PP5-183 Care Division, Royal Victoria Hospital, Montreal, QC. The Partial Rescue of Impaired Interferon-γ Signalling in Type I Interferon Receptor Defi cient Cells by Re-Expression of STAT1. Nicole PP 6 – CONTROL OF CELL GROWTH AND DEATH IN CANCER L. Messina, Daniel J. Gough, Linda Hii, Ricky Johnstone, Chris Clarke, AND HEMATOPOIESIS Peter MacCallum, Cancer Centre, St Andrews Place, East Melbourne, PP6-203 VIC Australia; Dept. Pathology, University of Melbourne, Parkville VIC GRIM-19: A Novel Cytokine-induced Tumor Suppressor. Dhan V. Kal- Australia. vakolanu, Sudhakar Kalakonda, Shreeram C. Nallar, Peng Sun, Depart- PP5-184 ment of Microbiology & Immunology, University of Maryland School of The NFκB Regulator Bcl10 is a Novel Stat5 Target Gene. Zsuzsanna S. Medicine, Baltimore, MD 21201, USA. Nagy, Matthew J. LeBaron, Hallgeir Rui and Robert A. Kirken, Depart- PP6-204 ment of Biological Sciences, University of Texas at El Paso, El Paso, TX. Pre-operative Intracellular Peripheral Monocyte Glutathione Levels PP5-185 Correlate with Anti-tumor Immune-responses and Predict Overall IKK-related Kinases are Repressors of HIF-1 Transcriptional Activity. Survival of Patients with Colorectal Carcinoma. Kazuko Uno, Tomohiko Simon-Pierre Gravel, Darren E. Richard, Marc J. Servant, Faculté de Matsuzaki, Katsumi Yagi, Junji Hamuro, Kiyotaka Okuno, Louis Pasteur Pharmacie, Université de Montréal, Montréal, QC. Center for Medical Research, Kyoto, Japan. PP5-186 PP6-205 Inductive and Suppressive Networks Regulate TLR9-dependent Gene Interleukin-7 Controls Glucose Uptake in T-lymphocytes by Regulating Expression in vivo. Sven Klaschik, Debra Tross, Dennis M. Klinman, Hexokinse II Gene Expression. Mounir Chehtane and Annette R. Khaled, Laboratory of Experimental Immunology, National Cancer Institute, NIH, Biomolecular Science Center, Burnett School of Biomedical Sciences, Frederick, MD. Cytokines Montreal 2008 33 Tuesday, October 14, 2008
University of Central Florida, Orlando, FL. PA, Laboratory of Experimental Immunology, Cancer and Infl ammation Program, NCI - Frederick, MD. PP6-206 The Role for Interferon Regulatory Factor-2 on Megakaryopoiesis PP 7 – STRUCTURE AND FUNCTION OF CYTOKINES AND Mediated by IFN-γ Induction. Atsuko Masumi, Isao Hamaguchi, Madoka THEIR RECEPTORS Kuramitsu, Takuo Mizukami, Kazuya Takizawa, Haruka Momose, Seishir- PP7-225 ou Naito and Kazunari Yamaguchi, Department of Safety Research on Biological Activities and Detection of Cynomolgus Interferon-α Sub- Blood and Biological Products, National Institute of Infectious Diseases, types. Doranelly H. Koltchev, Michael Skawinski, Diane Vy, Xiao-Hong Japan. Lin, Sara Crisafulli, Karlene Moolchan, Lara Izotova, Edward Dolphin, PP6-207 Thomas B. Lavoie, William Clark, Ronald G. Jubin and Sidney Pestka, Apoptosis Detection: A Novel Multiplex Assay for the Luminex® PBL InterferonSource, Piscataway, NJ, USA. Mary M. Brodey, Wei Zheng, Jimin Wang, and Kevin xMAP™ Platform. PP7-226 Reagan, Invitrogen Corporation, Camarillo, CA. Multiple Roles for the SOCS Box. Julie Piessevaux, Delphine Lavens, PP6-208 Frank Peelman and Jan Tavernier, Department of Medical Protein Targeting the Expression of GM2/GD2-synthase in Tumor Cell Lines Research, VIB, Department of Biochemistry, Faculty of Medicine and Reduces Tumor Growth and Enhances Immune Responses. Rafael Health Sciences, Ghent University, A. Baertsoenkaai 3, 9000 Ghent, Fernandez-Botran, Shawn Greschel and David Roach, Department of Belgium. Pathology & Laboratory Medicine, University of Louisville, Louisville, KY. PP7-227 PP6-209 Design of High Affi nity interleukin-6 and gp130 Variants: Implications Anti-proliferative Effect of Interferon-β in Mucosal and Cutaneous Hu- for Cytokine-receptor Assembly. Nina Adam, Stephanie Tenhumberg, man Papilloma Virus (HPV)-transformed Keratinocytes. Chiantore M.V., Georg H. Waetzig, Athena Chalaris, Björn Rabe, Jan Suthaus, Dirk Vannucchi S., Accardi R., Tommasino M., Affabris E., Fiorucci G. and Seegert, Jürgen Scheller, Stefan Rose-John and Joachim Grötzinger, Romeo G., Dept of Infectious, Parasitic and Immune-mediated Diseases, Institute of Biochemistry, Christian-Albrechts-University Kiel, Kiel, Ger- Istituto Superiore di Sanità, Rome, Italy; Dept of Experimental Medicine, many, CONARIS Research Institute AG, Kiel, Germany. Sapienza University of Rome, Rome, Italy. PP7-228 PP6-210 Erythropoietin and Glucocorticoids Exert Antagonistic Effects on STAT- Regulation of NKG2D Ligand Expression by IL-10. Antonio E. Serrano, 5 Phosphorylation in Primary Human Erythroblasts. Emilia Stellacci, An- Marcela Gatica-Andrades, Evelyn Menares-Castillo, Macarena Garrido, tonella Di Noia, Katija Jelicic, Maria Zingariello, Angela Di Baldassarre, Carolina Hernández, Mercedes N. López, Flavio Salazar-Onfray, Juan C. Giovanni Migliaccio, Ronald Hoffman, Angela Battistini and Anna Rita Aguillón and María C. Molina, Programme of Immunology, ICBM, Medi- Migliaccio, Departments of Infectious, Parasitic and Immunomediated cal Faculty, University of Chile, Santiago, Chile. Diseases, Istituto Superiore Sanità, Rome, Italy. PP6-212 PP7-229 Programmed Death-1 Pathway Inhibits γc common Cytokine Signal– Does S100A12 Activate Mast Cells and Monocytes/Macrophages Via driven T-cell Proliferation and Survival. Wei Huang, Andre Tanel, Rage? Jesse Goyette, Weixing Yan, Su Yin Lim, Nick Di Girolamo and Francesco A Procopio, Simmone Fonseca, Bader Yassine-Diab, Julien Carolyn L. Geczy, Centre for Infection and Infl ammation Research, van Grevenynghe, Chao Qiu, Denis Gaucher, Zhong He, Mohamed School of Medical Sciences, University of New South Wales, Sydney, El Far, Yu Shi, Nicolas Chomont, Yuwei Zhang, Elias A Said, Labora- NSW, Australia. toire d’Immunologie, Centre de Recherche du Centre Hospitalier de PP7-230 l’Université de Montréal (CR-CHUM), Montréal, Canada. The Exon 3-encoded Domain of IL-15Ralpha Contributes to IL-15 High- PP6-213 affi nity Binding and is Crucial for IL-15 Antagonistic Effect of Soluble Cell Cycle and Translational Requirements for VSV oncolysis in Primary IL-15Ralpha. G. Bouchaud, L. Garrigue-Antar, V. Solé, A. Quéméner, CD4+ T-Lymphocytes. Stephanie Oliere, Vanessa Tumilasci, David Stojdl, Y. Boublik, E. Mortier, H. Perdreau, Y. Jacques and A. Plet, INSERM, Nahum Sonenberg, John Bell and John Hiscott, Molecular Oncology U892, Centre de Recherche en Cancérologie Nantes/Angers, Groupe Group, Lady Davis Institute - Jewish General Hospital and Depts. of Cytokines et Récepteurs, Nantes, France; Université de Nantes, IFR26, Microbiology and Medicine, McGill University, Montreal, QC. Nantes, France. PP6-214 PP7-231 Differential Biological Activities of E. Coli Produced Murine Interferon-α Structure Basis for the Molecular Recognition Between IL-15 and its Proteins on B16-F10 Cells. Doranelly H Koltchev, Michael Skawinski, Private Receptor IL-15Ralpha. Mami Chirifu, Chiharu Hayashi, Teruya Karlene Moolchan, Lara Izotova, Sara Crisafulli, Xiao-Hong Lin, Steven Nakamura, Sachiko Toma, Tsuyoshi Shuto, Hirofumi Kai, Yuriko Yamaga- Carbone, Thomas Lavoie, Ronald Jubin, William Clark and Sidney ta, Simon J. Davis and Shinji Ikemizu, Graduate School of Pharmaceuti- Pestka, PBL InterferonSource, Piscataway, NJ. cal Sciences, Kumamoto University, Kumamoto, Japan. PP6-215 PP7-232 Ecto-ATPase Expression Modulates the in vivo Rat Glioma Infl ammatory Dimerization of HVEM and BTLA in Cellular Membranes. Timothy C. Response and Promotes Tumor Growth. Elizandra Braganhol, Fernanda Cheung, Matthew G. Macauley, Lisa M. Oborne, and Carl F. Ware, B. Morrone, Andressa Bernardi, Màrcia R. Wink, Daiane Huppes, L, Division of Molecular Immunology, La Jolla Institute for Allergy and Biochemistry Department - UFRGS- ICBS - Porto Alegre, Brazil. Immunology, La Jolla, CA. PP6-216 PP7-233 STAT2 Contributes to Infl ammation-induced Colorectal Cancer. Ana M. The type I Interferon System of Atlantic Salmon. Veronica Bergan and Gamero, Anthony J. Scarzello, Matthew R.Young, Roycelynn Mentor- Børre Robertsen, Department of Marine Biotechnology. University of Marcel, Gerd Bobe, Jennifer Wise, and Nancy H. Colburn, Department Tromsø, Norwegian College of Fishery Science, Tromsø, Norway. of Biochemistry, Temple University School of Medicine, Philadelphia
34 Cytokines Montreal 2008 Tuesday, October 14, 2008
PP7-234 Julkunen, Department of Viral Diseases and Immunology, National Public Fine Tuning of Receptor-selectivity for TNF Using a Phage Display Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland. Yasuhiro Abe, System with One-step Competitive-subtractive Panning. PP8-254 Hiroko Shibata, Tetsuya Nomura, Hiroyuki Kayamuro, Yohei Mukai, Tula and Puumala Hantavirus NSs ORFs are Functional and the Products Tomoaki Yoshikawa, Yasuo Yoshioka, Madoka Taniai, Tsunetaka Ohta, Inhibit Activation of the Interferon-beta Promoter. Kirsi M. Jääskeläinen, Shinsaku Nakagawa, Haruhiko Kamada, Shin-ichi Tsunoda, Yasuo Tsut- Pasi Kaukinen, Ekaterina S. Minskaya, Angelina Plyusnina, Olli Vapalahti, sumi, National Institute of Biomedical Innovation (NiBio), Osaka, Japan. Åke Lundkvist, Richard M. Elliott, Friedemann Weber, Antti Vaheri, and PP7-235 Alexander Plyusnin, Department of Virology, Haartman Institute, Univer- Structure-function Relationship of TNF Based on 3D Structural Analysis sity of Helsinki, Helsinki, Finland. Yohei Mukai, Hiroko Shi- of Fully Active TNFR1-selective TNF Mutant. PP8-255 bata, Teruya Nakamura, Yasuo Yoshioka, Yasuhiro Abe, Tetsuya Nomura, Echinococcus Granulosus Escape the TH1 Protective Response. Manel Madoka Taniai, Tsunetaka Ohta, Shinji Ikemizu, Shinsaku Nakagawa, Amri, Dalila Mezioug, Samia Bouaziz and Chafi a Touil-Boukoffa, Team: Shin-ichi Tsunoda, Haruhiko Kamada, Yuriko Yamagata, Yasuo Tsutsumi, Cytokines and NOSynthase, Laboratory of Cellular and Molecular Biol- Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, ogy, Faculty of Biological Science, USTHB, Algiers, Algeria. Japan; Laboratory of Pharmaceutical Proteomics Project, National Institute of Biomedical Innovation (NiBio), Osaka, Japan. PP8-256 The Role of Type I Interferon in Legionella Infection of Murine and Hu- PP 8 – PATHOGEN EVASION OF THE HOST CYTOKINE RESPONSE man Macrophages. Courtney R. Plumlee, Christian Schindler, Depart- PP8-244 ment of Microbiology, Columbia University, New York, NY. HIV-1 Antagonizes Innate Antiviral Signaling Pathways by Targeting In- PP8-257 Brian Doehle and Michael Gale Jr., terferon Regulatory Factor-3 (IRF-3). The R1 Subunit of Herpes Simplex Virus Type 2 Ribonucleotide Department of Immunology, University of Washington, Seattle, WA USA. Reductase Protects Cells Against TNF-alpha and Double-Stranded- PP8-245 RNA-induced Apoptosis by Direct Interaction with Procaspase-8. Expression of H5N1 Non-Structural Protein 1 Alters Type I IFN Signal- Florent Dufour, A. Marie-Josée Sasseville, Stéphane Chabaud, Richard ing. Danlin Jia1, Eleanor N. Fish1,2, 1Department of Immunology, Univer- M Siegel, Bernard Massie and Yves Langelier, Centre de recherche du sity of Toronto, Canada. 2Division of Cellular and Molecular Biology, Centre hospitalier de l’Université de Montréal and Institut du cancer de Toronto General Research Institute, Canada. Montréal, Hôpital Notre-Dame, Montreal, QC. PP8-246 PP8-258 Gingival Epithelial Cells Reduce C. Albican Pathogenesis Through Vaccinia Virus Protein E3L Inhibits Type I Interferon Induction by the Cytokine Production. M. Rouabhia, Groupe de Recherche en Écologie Cytoplasmic Signaling Pathway. Eugene Friedman, Isabelle J. Marié Buccale, Faculté de Médecine Dentaire, Université Laval, QC. and David E. Levy, Department of Pathology and NYU Cancer Institute, Molecular Oncology and Immunology Program, New York University PP8-247 School of Medicine, New York, NY. A Vaccinia Virus Deletion Mutant Reveals Additional Inhibitors of NFκB. Katharine Fagan, Brianne Couturier, Nick van Buuren, Crystal PP8-259 Harmon, Joanna Shisler and Michele Barry, Department of Medical Antagonism of the Innate Immune Response by Human Rhinovirus 1a. Microbiology and Immunology, University of Alberta, Edmonton, AB. Jennifer Drahos and Vincent Racaniello, Department of Microbiology, Columbia University, New York, NY, Department of Microbiology, PP8-249 Columbia University College of Physicians & Surgeons, 701 W. 168th Leishmania Promastigotes Modulate Macrophage Signal Transduction Street, New York, NY. by Targeting Host Protein Tyrosine Phosphatases in a GP63-dependent Manner. Maria Adelaida Gomez, Irazu Contreras, Laleh Alisaraie, Max- PP8-260 ime Halle, Michel L. Tremblay, Albert M. Berghuis, Robert W. McMaster Type I IFN and ISG Expression in Primary Hepatocytes Following and Martin Olivier, Department of Microbiology and Immunology, dsRNA Stimulation and Expression Disruption by HCV Protease NS3/4A. McGill University, Montreal, QC. Loubna Jouan, Pierre Melançon, Ian Gaël Rodrigue-Gervais, Valerie- Ann Raymond, Subajini Selliah, Marc Bilodeau, Rafi ck-Pierre Sékaly, PP8-250 Nathalie Grandvaux and Daniel Lamarre, Laboratoire d’immunologie A Role for CCR5 in Dissemination of Vaccinia Virus in vivo. Ramtin Rahbar, Thomas T. Murooka & Eleanor N. Fish, Toronto General virale, Département de Sciences Biomédicales, Université de Montréal, Research Institute, University Health Network and Department of QC. Immunology, University of Toronto, Toronto, ON. PP8-261 PP8-251 Activation of TLR-independent Signaling Pathway by HIV-1 in Primary Mayra Solis, Thibault Mesplede, Peyman Nakhaei Roles of IFN and Rnase L in the Inhibition of the Human Retrovirus, Human Macrophages. and John Hiscott, Lady Davis Insitute for Medical Research, and Depart- XMRV. Beihua Dong, Malathi Krishnamurthy, Ao Zhang, and Robert H. Silverman, Dept. of Cancer Biology, Lerner Research Institute, Cleveland ments of Microbiology & Immunology and Medicine, McGill University, Clinic, Cleveland, OH. Montreal, QC. PP8-252 Hepatitis C Virus Impairs Cytokine Production by Immune Cells. Marie- 19:30 EVENING AT THE MONTREAL MUSEUM OF FINE ARTS Eve Bilodeau, Emmanuel Moreau, Esther Tarrab and Alain Lamarre, Immunovirology Laboratory, INRS-Institut Armand-Frappier, Laval, QC. PP8-253 Hepatitis C Virus NS3/4A Protein Downregulates Toll-like Receptor 7 Signalling Pathway. Maarit Sillanpää, Pasi Kaukinen and Ilkka
Cytokines Montreal 2008 35 Wednesday, October 15, 2008
PLENARY SESSION 3 LE GRAND SALON
CYTOKINES AND EMERGING INFECTIOUS PATHOGENS
Chairpersons: Eleanor Fish, University Health Network (Canada) Adolfo Garcia-Sastre, Mount Sinai School of Medicine (USA) 08:30 PL3-14 H5N1 and Interferons-α/ß: A Battle for Supremacy. Danlin Jia, Jae K. Yoo, Daniel Burke, John Nicholls, Eleanor N. Fish, Toronto General Research Institute, University Health Network & Department of Immunology, University of Toronto, Toronto, ON. 09:00 PL3-15 Modulation of Infl uenza Virus Replication and Virulence by Viral-host Protein Interactions. Adolfo García-Sastre, Department of Microbiology, Mount Sinai School of Medicine, New York, NY. 09:30 PL3-16 Ebola and Marburg Viruses: Immunopathology and Immunoprotection. Heinz Feldmann, Laboratory of Virology, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT. 10:00 PL3-17 Poxvirus Immune Evasion and Host Tropism are Linked by Cytokines. Grant McFadden, Dept. Molecular Genetics and Microbiology University of Florida, Gainesville, FL.
10:30 COFFEE BREAK – FOYER
11:00 PL3-18 Viral and Host Control of Innate Immune Defenses in Hepatitis C Virus Infection. Michael Gale Jr. and the Gale Laboratory, Department of Immunology, University of Washington, Seattle WA. 11:30 PL3-19 Activation and Inhibition of Interferon and Cytokine Signaling by Emerging Pathogens. Curt M. Horvath, Evanston Northwestern Healthcare, Northwestern University, Evanston, IL. 12:00 PL3-27 Severe SARS Coronavirus Infection in Aged Macaques is Associated with Reduced Expression of Anti-Infl ammatory Type-1 Interferons. Bart L. Haagmans, Saskia L. Smits, Anna de Lang, Judith M.A. van den Brand, Lonneke M.E. Leijten, Arno Andeweg, Geert van Amerongen, Thijs Kuiken, and Albert D.M.E. Osterhaus, Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands. 12:15 PL3-236 SARS-Coronavirus Inhibits Interferon Induction both at Pre and Post-transcriptional Levels. Thomas Kuri, Xiaonan Zhang, Luis Martinez-Sobrido, Adolfo García-Sastre, Zhenghong Yuan, Friedemann Weber, Department of Virology, University of Freiburg, Freiburg, Germany.
12:30 LUNCH BREAK – ON YOUR OWN
12:30 – 14:00 ICS General Membership Meeting – MARQUETTE 12:30 – 14:00 ISICR General Membership Meeting – JOLLIET
36 Cytokines Montreal 2008 Wednesday, October 15, 2008
WORKSHOP 9 JOLLIET WORKSHOP 10 MARQUETTE CYTOKINES IN THE DEVELOPMENT OF INNATE AND INDUCTION OF CYTOKINES AND INTERFERONS ADAPTIVE IMMUNITY Chairpersons: Takashi Fujita, Osaka University (Japan) Chairpersons: Ana Gamero, Temple University (USA) Otto Haller, University of Freiburg (Germany) Simon Jones, Cardiff University (UK) 14:00 WO10-289 14:00 WO9-262 NOX2: A Novel Regulator of Pro-infl ammatory Cytokine Development and Maintenance of T-cells Require Post- Production in Response to Respiratory Virus Infections. Nathalie Translational Regulation of Anti-apoptotic MCL-1 and Pro- Grandvaux, Karin Fink, Alexis Martel, Anton Soucy-Faulkner and apoptotic BIM by IL-7. Wenqing Li, Tad Guszczynski, Julie Hixon, Annick Duval, CRCHUM and Department of Biochemistry, and Scott K. Durum, Laboratory of Molecular Immunoregulation, Université de Montréal, Montréal, QC. Cancer and Infl ammation Program, CCR, National Cancer 14:15 WO10-290 Institute. NIH, Frederick, MD. Defi ning the Pathogen Associated Molecular Patterns (PAMPs) 14:15 WO9-263 of RNA Viruses and Their Recognition by RIG-I to Mediate Interferon Regulatory Factor-1 Eradicates Tumors by Inducing Innate Immune Defenses. Takeshi Saito, David Owen, Fuguo Immune Responses Through T-cell Stimulation and Regulatory Jiang, Joseph Marcotrigiano, and Michael Gale Jr., Department T-cell Inhibition. Katjana Klages, Antje Ksienzyk, Hansjörg of Immunology, University of Washington School of Medicine, Hauser, and Andrea Kröger, Department of Gene Regulation and Seattle, WA. ISICR Young Investigator Award Differentiation, Helmholtz Centre for Infection Research, Braun- 14:30 WO10-291 schweig, Germany. Polo-like Kinase 1 (PLK1) and Protein Kinase IKK Epsilon – Two 14:30 WO9-264 Markers of Cancer – Down-regulate IFN Induction by MAVS. The Infl ammatory Traffi cking of Monocytic Cells in IL-6-defi cient Damien Vitour, Stéphanie Dabo, Malek Ahmadi Pour, Myriam Mice Highlights the Emergence of a CD11c+ Monocytic Popula- Vilasco, Pierre-Olivier Vidalain, Yves Jacob, Pascal Pineau, tion. Victoria J Hammond, Vincent Dioszeghy, Chantal Colmont, Frédéric Tangy, John Hiscott and Eliane F. Meurs, Unit of Hepaci- Emily Hams, Gareth W Jones, Nicholas Topley, Valerie O’Donnell, virus and Innate Immunity, Pasteur Institute, Paris, France. Philip R Taylor, Simon A Jones, Medical Biochemistry and 14:45 WO10-292 Immunology, Cardiff University, Cardiff, UK. p53 Transcriptionally Activates IRF9 to Enhance Antiviral 14:45 WO9-278 Immunity. César Muñoz-Fontela, Salvador Macip, Luis Martínez- Lymphotoxin-beta Receptor Signaling in the Intestine is Critical Sobrido, Rana Elkholi, Lauren Brown, Joseph Ashour, Adolfo for Recruitment of Dendtric Cells that Contribute to IGA Class García-Sastre, Sam W. Lee and Stuart A. Aaronson, Department Switch Recombination. Douglas McCarthy, Leslie Summers of Oncological Sciences, Mount Sinai School of Medicine, deLuca, Lesley Ward, Hang Shi and Jennifer Gommerman, New York, NY. ISICR Young Investigator Award University of Toronto Department of Immunology, Toronto, ON. 15:00 WO10-293 ICS Outstanding Scholar Award IFN-gamma 3’untranslated Region AU-RICH Element-deleted 15:00 WO9-266 Mice have Altered Immune Structure and Function. Deborah L. The Interferon Sensitivity of Tick-borne Encephalitis Virus is Hodge, Cyril Berthet, Jeff Subleski, William Bere, Xin Chen, Partially Mediated by Double-stranded RNA-dependent Protein Vincenzo Coppola, Matthew Buschman, Thomas Wolfe, Isabelle Kinase. Anna K Överby, Friedemann Weber, Department of Shuggi, Howard A. Young, Laboratory of Experimental Immunol- Virology, University of Freiburg, Freiburg, Germany. ogy, Center for Cancer Research, National Cancer Institute- 15:15 WO9-269 Frederick, Frederick, MD. Coordinated Expression of IFN-λ1 and IL-4, a Novel Feedback 15:15 WO10-294 Loop Leading to the Reduction of Th2 Responses. G. Gallagher, Viral Targeting of Human DEAD-box Protein 3 Reveals its Novel GE. Gallagher, J. Dai & N. Megjugorac, Humigen-Genetic Role in IRF3/7 Activation. Martina Schröder, Marcin Baran and Immunology Laboratory. Hamilton, NJ. Andrew G. Bowie, School of Biochemistry and Immunology, 15:30 WO9-267 Trinity College Dublin, Ireland. Interferon-λ Contributes to Innate Immunity of Mice Against ICS Post-Doctoral Investigator Award Infl uenza A Virus but not Against Hepatotropic Viruses. Markus 15:30 WO10-295 Mordstein, Georg Kochs, Laure Dumoutier, Jean-Christophe Membrane Fusion Activates Interferon Regulatory Factor 3. Renauld, Søren R. Paludan, Kevin Klucher, and Peter Staeheli, Ryan Noyce, Kathryne Taylor, and Karen Mossman, Department Department of Virology, University of Freiburg, Freiburg, Germany. of Biochemistry and Biomedical Sciences, McMaster University, 15:45 WO9-268 Hamilton, ON. A Role for Intra-cellular Interleukin-1alpha in Antiviral Defense. 15:45 WO10-298 Ariel Werman, Ben Alkahe, Charles A. Dinarello and Menachem Receptor and Cell-specifi c Function of MAP3K8/TPL2 in Innate Rubinstein, Dept. of Molecular Genetics, Weizmann Institute of Immune Signaling and Cytokine Production. Lisa A Mielke, Science, Rehovot, Israel. Karen Elkins, Robyn Starr, Douglas J Hilton, Philip Tsichlis, John 16:00 COFFEE BREAK – FOYER J O’Shea, Wendy T Watford, Molecular Immunology and Infl am- mation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD. ICS Outstanding Scholar Award 16:00 COFFEE BREAK – FOYER
Cytokines Montreal 2008 37 Wednesday, October 15, 2008
WORKSHOP 11 DULUTH 16:00 WO11-328 Generation of Interleukin-6 Receptor-defi cient Mice and Effect CYTOKINES IN PRECLINICAL MODELS OF CANCER on Ovarian Cancer Progression. Molly M. McFarland, Holly F. AND INFECTIOUS DISEASE Funk, Sara Kozma, Mingfu Zhou, Angela F. Drew, Department of Chairpersons: Howard Young, NCI-Frederick (USA) Cancer and Cell Biology, University of Cincinnati, Cincinnati, OH. Allan Lau, University of Hong Kong (China) 16:15 COFFEE BREAK – FOYER 14:00 WO11-321 IL-11 Dependent Gastric Tumourigenesis in GP130 Receptor WORKSHOP 12 LE GRAND SALON Mutant Mice. Tracy L. Putoczki, Andrew G. Jarnicki, Therése SIGNAL TRANSDUCTION II Lundgren-May, Brent S. Mckenzie, Brendan Jenkins, Matthias Ernst, Ludwig Institute for Cancer Research, Melbourne, Victoria, Chairpersons: George Stark, Cleveland Clinic (USA) Australia. John Schrader, University of British Columbia (Canada) 14:15 WO11-322 14:00 WO12-346 Chemical Targeting of the Innate Antiviral Response by Histone Promoter Insertion Reveals Lysine Demethylase FBXL11 as a κ Deacetylase Inhibitors Renders Refractory Cancers Sensitive Negative Regulator of NF B. Tao Lu*, Mark W. Jackson, Aatur to Viral Oncolysis. Thi Lien-Anh Nguyên, Hesham Abdelbary, D. Singhi, Eugene Kandel, Benlian Wang, Maojing Yang, Yi Meztli Arguello, Simon Leveille, John C. Bell and John Hiscott, Zhang, Mark Chance, Masaru Miyagi, Andrei V. Gudkov, and Lady Davis Institute - Jewish General Hospital and Dept. of George R. Stark, Department of Molecular Genetics, Lerner Microbiology & Immunology, McGill University, Montreal, QC. Research Institute, Cleveland Clinic Foundation, Cleveland, OH. ISICR Young Investigator Award (also PP12-346) 14:30 WO11-323 Microbial Interactions in AIDS Pathogenesis: HIV-TAT Suppres- 14:30 WO12-350 sion of Endotoxin-TLR4 Induced Interferon Induction and Defi ning the Biology of IPS-1 in Innate Immunity. Yueh-Ming Loo Cytokine Dysregulation. Howard CH Yim, James CB Li, Davy CW and Michael Gale Jr., Department of Immunology, University of Lee, Allan S Lau, Cytokine Biology Group, Department of Paedi- Washington School of Medicine, Seattle, WA. atrics and Adolescent Medicine, and Bio-Screening Unit, Li Ka ISICR Christina Fleischmann Award Shing Faculty of Medicine, The University of Hong Kong, 14:45 WO12-347 Pokfulam, Hong Kong, China. Regulation of Innate Immune Responses by DAI (DLM-1 / ZBP1) 14:45 WO11-324 and Other DNA-sensing Molecules. ZhiChao Wang, Hideyuki IL-27 is a Novel Anti-viral Cytokine that Inhibits Replication of Yanai, Myoung Kwon Choi, Tatsuma Ban, Tomohiko Tamura, HIV-1 and HCV. Terrence W. Brann, Jun Yang, Da-Wei Huang, Akinori Takaoka, Kazuko Nishikura, and Tadatsugu Taniguchi, Astrid Frank, Richard A. Lempicki, Michael W. Baseler, Shaym Department of Immunology, Graduate School of Medicine and Kottilili, H. Clifford Lane, and Tom Imamichi, Laboratory of Human Faculty of Medicine, University of Tokyo, Tokyo, Japan. Retrovirology, NCI-Frederick, Frederick, MD. ICS Outstanding Scholar Award 15:00 WO4-51 15:00 WO12-348 α Intranasal Administration of Interferon-alpha Reduces Infl uenza Role of the Protein Kinase TBK1 in TNF -induced Apoptosis. A Morbidity in Ferrets. Daniela Kugel, Georg Kochs, Joachim Mireille Delhase, Takashi Yagi, Koichi S. Kobayashi and Makoto Roth, Darwyn Kobasa, Michael Gray, Otto Haller, Peter Staeheli, Nakanishi, Department of Immunology and AIDS, Dana Farber and Veronika von Messling, Institute Armand-Frappier, University Cancer Institute and Department of Pathology, Harvard Medical of Quebec, Montreal, QC. School, Boston, MA. 15:15 WO11-325 15:15 WO12-360 IFNα Induces Long-lasting Refractoriness of JAK-STAT Signal- Cross-regulation of Cytokine Signalling: Pro-infl ammatory ing in the Mouse Liver Through Induction of the Negative Cytokines Restrict IL-6 Signalling Through Receptor Inter- Regulator USP18/UBP43. Magdalena Sarasin-Filipowicz, Xueya nalisation and Degradation. Simone Radtke, Xiang-ping Yang, Wang, Ming Yan, Francois H.T. Duong, Valeria Poli, Douglas J. Stefan Wüller, Matthias Gaestel, Peter C. Heinrich, Fred Schaper Hilton, Dong-Er Zhang, Markus H. Heim, Hepatology Laboratory, and Heike M. Hermanns, Department of Biochemistry, Medical Department of Biomedicine, University Hospital Basel, Basel, School RWTH Aachen, DFG Research Center for Experimental Switzerland. Biomedicine, Würzburg, Germany. ICS Young Investigator Award 15:30 WO11-326 Combined Intra-tumoural Regulatory T-cell Depletion and Trans- 15:30 WO12-351 forming Growth Factor-β Neutralisation Induces Regression Differential Requirement of MALT1 for BAFF-induced Outcomes of Established AE17 Murine Mesothelioma Rumours. Haydn T in B Cell Subsets. Michael W. Tusche, Lesley A. Ward, Frances Kissick, Demelza J Ireland, Manfred W Beilharz, Discipline of Vu, Doug McCarthy, Miguel Quintela-Fandino, Tak W. Mak and Microbiology & Immunology, School of Biomedical, Biomolecular Jennifer L. Gommerman, Department of Immunology, Faculty of and Chemical Sciences, University of Western Australia, Medicine, University of Toronto, Toronto, ON. Crawley, Australia. 15:45 WO12-352 15:45 WO11-327 Suppressor of Cytokine Signalling (SOCS)-5 Regulates IL-4 Immunotherapy with CpG Oligonucleotides and Antibodies to Activity Via Interaction with the IL-4 Receptor and Inhibition TNFα Rescue Neonatal Mice from Lethal Arena Virus-induced of JAK1 Kinase Activity. Tatiana Kolesnik, Ruth E. Columbus, Meningoencephalitis. João A. Pedras-Vasconcelos, Montserrat Anjana Chakravorty, Tracy A. Willson, Naomi S. Sprigg, Wendy Puig, Christian Sauder, Candie Wolbert, Mikhail Ovanesov and Carter, Jian-Guo Zhang, Nicos A. Nicola and Sandra E. Nichol- Daniela Verthelyi, Division of Therapeutic proteins-CDER- FDA, son, The Walter and Eliza Hall Institute of Medical Research, Bethesda, MD. Parkville, Victoria, Australia. 16:00 COFFEE BREAK – FOYER 38 Cytokines Montreal 2008 Wednesday, October 15, 2008
SYMPOSIUM 5 LE GRAND SALON
CYTOKINE SIGNALING IN THE IMMUNE RESPONSE
Chairpersons: Christian Schindler, Columbia University (USA) Warren Leonard, NIH (USA) 16:30 SY5-18 Signaling and Gene Regulation by γc-Dependent Cytokines. Warren Leonard, Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, NIH, Bethesda, MD. 17:00 SY5-19 From Epithelial Innate to Adaptive Immune Response: Cross Talk Between Epithelial Cells and Dendritic Cells. Yong-Jun Liu, Department of Immunology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX. 17:20 SY5-20 The TBK-1 Substrate DDX3X, a DEAD-box RNA Helicase, Provides Innate Immunity to Listeria Monocytogenes. Thomas Decker, Didier Soulat, Tilmann Bürckstümmer, Sandra Westermayer, Adriana Goncalves, Angela Bauch, Adrijana Stefanovic, Oliver Hantschel, Keiryn L. Bennett and Giulio Superti-Furga, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria. 17:40 SY5-21 Cytokine Signals Regulate the Interface of Innate and Adaptive Immunity. Li Song, Courtney Plumlee, Carolyn Lee, John Seeley, Govind Bhagat, Ana Belen Blazquez, Cecilia Berin, Boris Reizis, and Christian Schindler, Departments of Microbiology, Medicine and Pathology, Columbia University, New York, NY.
SYMPOSIUM 6 MARQUETTE / JOLLIET
REGULATORY T CELLS
Chairpersons: Ethan Shevach, Laboratory of Immunology, NIAID, NIH (USA) Ciro Piccirillo, McGill University (Canada) 16:30 SY6-22 Control of Immune Responses by Natural and Adaptive Regulatory T-cells. Ethan M. Shevach, Eva Huter, Dat Tran, and John Andersson, Laboratory of Immunology, NIAID, NIH, Bethesda, MD. 17:00 SY6-23 Human CD4+CD25high Natural Tregs and Th17 Effector Cells are Related. Clare Baecher-Allan, Gaëlle Beriou, Li Yang, William Hastings, David Anderson, Vijay K. Kuchroo and David A. Hafl er, Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA. 17:20 SY6-24 Thymic and Peripheral Regulatory T-cell Development. Chyi-Song Hsieh, Chan Wang Lio, Stephanie K. Lathrop, Jhoanne Bautista, Hyang Mi Lee, and Nicole San, Washington University, St. Louis, MO. 17:40 SY6-25 Adaptive Foxp3+ Regulatory T-cells. Maria A. C de Lafaille, Yi Ding, Juan J. Lafaille, Skirball Institute, New York University School of Medicine, New York, NY.
Cytokines Montreal 2008 39 Wednesday, October 15, 2008
POSTER DISCUSSION 3 18:00 – 19:30 HOCHELAGA 2 PP9-273 Interleukin-12 Enhances the Fungicidal Activity of Neutrophils from 18:00 PD3-258 Gerbils with Sporothrix Schenckii Infection. Aurelio Flores-García, Vaccinia Virus Protein E3L Inhibits Type I Interferon Induction by Porfi rio López-Lugo, Pedro Aguiar-García, Nidia K. Castillón-Benavides, the Cytoplasmic Signaling Pathway. Eugene Friedman, Isabelle Omar J. Castillón-Benavides, José R. Altamirano-Gallegos, Rogelio J. Marié and David E. Levy, Department of Pathology and NYU Sánchez-Gutiérrez, Eloy A. Zepeda-Carrillo, Martha Barba-Barajas Cancer Institute, New York University School of Medicine, and Vicente Garibald, Unidad Académica de Medicina, Universidad New York, NY USA. Autónoma de Nayarit, Tepic, Nayarit, México. 18:15 PD3-349 PP9-274 Investigation of the Mechanism of IRAK-2-mediated NFκB Identifi cation of Small RNAs Produced by Cleavage of Hepatitis C Viral Activation Via Stimulation of TRAF6 Ubiquitination. Sinéad RNA with RNase L that Bind RIG-I. Krishnamurthy Malathi, Michael Flannery, Sinéad Keating and Andrew Bowie, School of Bio- Gale, and Robert H. Silverman, Dept. of Cancer Biology, Lerner Research chemistry and Immunology, Trinity College Dublin, Ireland. Institute, Cleveland Clinic, Cleveland, OH. ICS Outstanding Scholar Award PP9-275 18:30 PD3-355 Interferon Subtype Stimulation of Dendritic Cells: Key Activators of Triad3A E3 Ligase Negatively Regulates the RIG-I/MAVS Signal- Anti-viral Immunity. Cassandra M James, Seamus Duffy, Dean Pem- ing Pathway by Targeting TRAF3 for Degradation. Peyman berton, Anthony Armson, Philip A Stumbles, School of Veterinary and Nakhaei, Thibault Mesplede, Qiang Sun, Mayra Solis, Long Yang, Biomedical Sciences, Murdoch University, Perth, Western Australia, Rongtuan Lin, Tsung-Hsien Chuang, Carl F. Ware, John Hiscott, Australia. Lady Davis Institute, McGill University, Montreal, QC. PP9-276 18:45 PD3-296 Annexin-1 Regulates Cytokines and Dexamethasone Sensitivity Via Role of Interferon Regulatory Factor 5 in Regulation of the Glucocorticoid-induced Leucine Zipper. Yuan H. Yang, Daniel Aeberli, Human Tumor Necrosis Factor Gene Expression. Thomas Michelle Leech, April Dacumos, Jin R. Xue and Eric F. Morand, Centre Krausgruber, Scott JP. Thomson, David G. Saliba, Irina A. for Infl ammatory Diseases, Department of Medicine, Monash University, Udalova, Kennedy Institute of Rheumatology, Imperial College Clayton, Victoria, Australia. London, London, UK. PP9-277 Mutant TNF Elicits Th2-type Responses for Enhanced Mucosal Immu- POSTER SESSION 3 18:00 – 19:30 HOCHELAGA 2-6 nity. Hiroyuki Kayamuro, Yasuo Yoshioka, Kazufumi Katayama, Haruhiko PP 9 – CYTOKINES IN THE DEVELOPMENT OF INNATE AND Kamada, Tetsuya Nomura, Yasuhiro Abe, Takachika Hiroi, Shin-ichi ADAPTIVE IMMUNITY Tsunoda, Yasuo Tsutsumi, National Institute of Biomedical Innovation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, PP9-107 Japan. Bioactive Chicken IL-12: Plant-derived Protein Production Platform Compatible with Veterinary Vaccine Applications. Giuliana Medrano, PP9-279 Nathan Stephans, David Radin, Maureen C. Dolan, and Carole L. Cramer, Type I IFNs Affect Early Thymocyte Development. Dominique Gauchat, Arkansas Biosciences Institute, Arkansas State University, Jonesboro, Marie-Laurence Baron, Ross La Motte-Mohs, Juan-Carlos Zúñiga- AR. Pfl ücker, and Rafi ck-Pierre Sékaly, Laboratoire d’Immunologie, Centre de Recherches du CHUM, Hôpital Saint-Luc, Montréal, Qc., Canada; PP9-265 Département de Microbiologie et Immunologie, Faculté de Médecine, Early but not Late Interferon Alpha Therapy Against Hepatitis C Rescues Université de Montréal, Montréal, Montréal, Qc., Canada; Unité INSERM Polyfunctional CD4+ and CD8+ Memory T-Cells. Mohamed S. Abdel- U743, Immunologie humaine. Centre de Recherches du CHUM, Hôpital Hakeem, Nathalie Bédard, Gamal Badr, Mario Ostrowski, Julie Bruneau, Saint-Luc, Montréal, QC. Rafi ck P. Sékaly, Bernard Willems, Jenny E. Heathcote and Naglaa H. Shoukry, Centre de Recherche du Centre Hospitalier de l’Université de PP9-280 Montréal (CHUM), Hôpital St-Luc, Université de Montréal, Montréal, QC. SGLT-1 as a Novel Immunological Player in the Intestinal Mucosa. Marco Palazzo, Silvia Gariboldi, Laura Zanobbio, Silvia Selleri, Giusep- PP9-270 pina F Dusio, Valentina Mauro, Anna Rossini, Andrea Balsari and λ Production of, and Response to, IFN- 1 by Plasmacytoid Dendritic Cristiano Rumio, MIL- Mucosal Immunity Laboratory, Department of Cells. N. Megjugorac, GE. Gallagher, G. Gallagher, Humigen-Genetic Human Morphology, Università degli Studi di Milano, Milan, Italy. Immunology Laboratory, Hamilton NJ. PP9-281 PP9-271 Low Molecular Weight Hyaluronic acid Increases the Self Defence λ IFN- 1 (IL-29) Suppresses the Differentiation of Human Naive and of Skin Epithelium by Induction of β-defensin 2 via TLR2 and 4. Silvia Memory Th2 Cells Without Inhibiting their Proliferation. J. Dai, Gariboldi, Marco Palazzo, Laura Zanobbio, Silvia Selleri, Michele N. Megjugorac, GE. Gallagher & G. Gallagher, Humigen-Genetic Sommariva, Andrea Balsari, Cristiano Rumio, MIL – Mucosal Immunity Immunology Laboratory, Hamilton, NJ. Laboratory, Department of Human Morphology, Università degli Studi di PP9-272 Milano, Milan, Italy. Antigen-independent Proliferation and Functional Differentiation of PP9-282 CD8 T Lymphocytes Stimulated by IL-6 in the Presence of IL-7 OR IL-15. Alpha-1-Antitrypsin is an Endogenous and Specifi c Inhibitor of Pro- Subburaj Ilangumaran, Julien Gagnon, Chantal Leblanc and Sheela infl ammatory Cytokine Production in Whole Blood. Gregory B. Pott, Ramanathan, Immunology division, Department of Pediatrics, Faculty of Edward D. Chan, Charles A. Dinarello, and Leland Shapiro, Denver Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Veterans Affairs Medical Center, National Jewish Medical and Research QC. Center, Denver, CO.
40 Cytokines Montreal 2008 Wednesday, October 15, 2008
PP9-283 PP10-302 Alpha-1-Antitrypsin is an Inhibitor of Intracellular Pro-infl ammatory Examining the Role of Nuclear Factor Kappa-B Proteins in Human Cytokine Production in Monocytes and T-cells. Scott Beard, Gregory B. Cytokine Gene Expression: Comparison of Type I and Type III Pott, Kristin Morris, Brent Palmer, and Leland Shapiro, Denver Veterans Interferons. Fui Goon Goh, Scott J.P. Thomson and Irina A. Udalova, Affairs Medical Center and University of Colorado Denver, Denver, CO. Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, London, UK. PP9-284 The Effect of IL-6 Overproduction in vivo on the Balance of Foxp3+ PP10-303 Regulatory T-cells and Th17 Cells. Minoru Fujimoto, Fumitaka Terabe, Toll-like Receptor 4/MyD88 Pathway Mediates Microglial Proinfl amma- Satoshi Serada, Teppei Nishikawa, Yuko Matsukawa, Tomoharu Oh- tory Cytokine Responses to Thrombin-associated Coagulation Protein kawara, Jiro Horino, Barry Ripley, Akihiro Kimura, Tadamitsu Kishimoto Complexes. Jörg Scheffel, Denise van Rossum, Jonathan R. Weinstein, and Tetsuji Naka, Laboratory for Immune Signal, National Institute of Hassan Dihazi, Tommy Regen, Wolfgang Brück, Helmut Kettenmann, Biomedical Innovation, Osaka University, Japan. Marco Prinz, Thomas Möller and Uwe-Karsten Hanisch, Institute of Neuropathology, University of Göttingen, Germany. PP9-285 TSLP as a Mediator of Crosstalk Between Bronchial Smooth Muscle PP10-304 and Mast Cells. Michael R. Comeau, Zoulfi a Allakhverdi, Heidi K. Jessup, Glatiramer Acetate Induces IL-1 Receptor Antagonist and Inhib- and Guy Delespesse, Infl ammation Research, Amgen Inc, Seattle, WA. its the Induced Production of IL-1β in Human Monocytes. Danielle Burger, Nicolas Molnarfi , Martin S. Weber, Karim J. Brandt, Thomas PP9-286 Prod’homme, Lyssia Gruaz, Michel Choffl on, Scott S. Zamvil, Patrice H. Modulation of Humoral and Cellular Immune Responses Generated Lalive, Division of Immunology and Allergy, Clinical Immunology Unit, Against Hepatitis C Vrus Core DNA Vaccine by Utilizing Granulocyte University Hospital and Faculty of Medicine, University of Geneva, Monocyte-Colony Stimulating Factor and Interleukin-23 as Immunologi- Switzerland. cal Adjuvants. Christine Hartoonian, Massoumeh Ebtekar, Ali Karami, Mehdi Mahdavi, Kayhan Azadmanesh, Mehdi Yousefi pour, Department PP10-305 of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran Univer- Dynamic Accumulation of Plasmacytoid Dendritic Cells in Lymph sity of Medical Sciences, Tehran, Iran. Nodes is Regulated by Type I IFN-beta. Yunfei Gao, Beata Majchrzak, Eleanor Fish and Jennifer L. Gommerman, Department of Immunology, PP9-287 University of Toronto, Toronto, ON. ACT1 is Required for IL-25-dependent TH2 Responses. Shadi Swaidani, Katarzyna Bulek, Zizhen Kang, Caini Liu, Yi Lu, Mark Aronica, Xiaoxia Li, PP10-306 Department of Immunology, Cleveland Clinic, Cleveland, Ohio. IFN-β Induces the Expression of Secreted IL-1 Receptor Antagonist PP9-288 in Human Monocytes Through a MEK2/PI3K-dependent, ERK1/2-inde- Karim J. Brandt, Nicolas Molnarfi , Lyssia Gruaz, and Chimeric Fusokines Borne of the Marriage of the TGFβ Receptor II pendent Pathway. Danielle Burger, Division of Immunology and Allergy, Clinical Immunol- Ectodomain and Pro-infl ammatory Cytokines IL2 and GMCSF for Breast ogy Unit, University Hospital and Faculty of Medicine, University of Cancer Immunotherapy. Claudia A. Penafuerte-Diaz, Norma Bautista- Lopez and Jacques Galipeau, MCETC, McGill University, Montreal Geneva, Switzerland. Canada. PP10-307 PP 10 – INDUCTION OF CYTOKINES AND INTERFERONS Is Nuclear Accumulation of Interferon Regulatory Factor (IRF)-3 Depen- dent on a Functional Nuclear Localization Sequence? Annie Bibeau- PP10-296 Poirier, Jean-François Clément, Rongtuan Lin, Marc J. Servant, Faculty Role of Interferon Regulatory Factor 5 in Regulation of the Human Tumor of Pharmacy, University de Montreal, Montreal, QC. Necrosis Factor Gene Expression. Thomas Krausgruber, Scott JP. Thom- son, David G. Saliba, Irina A. Udalova, Kennedy Institute of Rheumatol- PP10-308 ogy, Imperial College London, London, United Kingdom. In vitro Effects on Cellular Metabolism and Cytopathic Expression of Vesicular Stomatitis Virus Strains. Valérie Janelle, Frédérick Brassard, PP10-297 Kathya Dupont, Alain Roy, Marc Desforges, Pierre Talbot, Alain Lamarre, Regulation and Functional Characterisation of a Novel Interferon, IFNε. Laurent Poliquin, Biomed Research Center and Department of Biology, KaYee Fung, Helen Cumming, Shamith Samarajiwa, Shelley Smal- Université du Québec à Montréal, Montreal, QC. lacombe and Paul Hertzog, Centre for Innate Immunity and Infectious Disease, Monash University, Clayton, Victoria, Australia. PP10-309 Ad-huPA Effects on Transcription Factors T-BET/GATA3 in Bleomycin- PP10-299 induced Experimental Scleroderma. Francisco J. Gálvez-Gastelum, Ana Cytokine Response to Liposome-encapsulated Poly ICLC Prophylaxis of L. Márquez-Aguirre, José Navarro-Partida, José M. Vera Cruz, Jaime Infl uenza A Virus Infection. Mary E. Christopher, Nina E.C. Karpoff, Sathi- González Cuevas, José Macías-Barragán, Jesús J. García-Bañuelos and yanarayanan Viswanathan, Xiaojiang Dai, Glen J. Schnell, Jonathan P. Juan S. Armendáriz Boruda, Instituto de Biología Molecular en Medicina Wong, Biotechnology Section, Defence R&D Canada – Suffi eld, Ralston, y Terapia Génica. CUCS. Universidad de Guadalajara, México. AB. PP10-310 PP10-300 Lipopolysaccharide: A Potent Inhibitor of Interferon Induction. Christo- TNF Production Induced by Staphylococcus Aureus Involves Different pher P. Malinoski, John M. Ngunjiri, Margaret J. Sekellick, and Philip I. Signalization Pathways in Monocytes, Alveolar Macrophages and Peri- Marcus, Dept. Molecular & Cell Biol., University of Connecticut, Storrs, toneal Macrophages. Ronan Kapetanovic, Catherine Fitting, Jean-Marc CT. Cavaillon, Minou Adib-Conquy, Institut Pasteur, Paris, France. PP10-311 PP10-301 Molecular Networks in Innate Immunity. Tilmann Burckstummer, Evren ELISpot and Cytokine Levels are Markers of Cell Mediated Immunity. Karayel, Evelyn Dixit, Adriana Goncalves, Gerhard Durnberger, Hannah Geetanjali Gupta, Arif Azam Khan, D. N. Rao, India Institute of Medical Jahn, Melanie Planyavsky, Jacques Colinge, Keiryn L Bennett and Giulio Sciences, New Delhi, India. Cytokines Montreal 2008 41 Wednesday, October 15, 2008
Superti-Furga, CeMM, Research Center for Molecular Medicine of the dinova, and Boryana K. Popivanova, Division of Molecular Bioregulation, Austrian Academy of Sciences Vienna, Austria. Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan. PP10-312 Infl uenza A Virus Induces an Immediate Cytotoxic Effect by all Major PP11-331 Subsets of Peripheral Blood Mononuclear Cells. Monika Sachet, Sanda Innate Immunity: Preclinical Study of Eradication of Tumor Cells by Sturlan, Suzann Baumann, Andreas Spittler and Michael Bergmann, IFN-activated Monocytes in vitro and in vivo. Samuel Baron, Joyce Dept. of General Surgery, Medical University of Vienna, Vienna, Austria. Poast, Fujio Suzuki, and Makiko Kobayashi, Kathleen Clouse, Sylvia Bacot, Linda Tiffany, Carla Lankford, Gunther Boekhoudt, Angel PP10-313 Morrow, Samuel Fey, Hana Schmeisser, Joseph Bekisz, and Kathryn Induction of IFN Responses in Infl uenza B Virus-infected Human Mono- Zoon, University of Texas Medical Branch, Dept. of Microbiology and cyte-derived Dendritic Cells. Pamela Österlund, Mari Strengell and Ilkka Julkunen, Department of Viral Diseases and Immunology, National Immunology, Galveston, TX; University of Texas Medical Branch, Dept. Public Health Institute, Helsinki, Finland. of Internal Medicine, Galveston, TX; NIAID, NIH, Bethesda, MD. PP10-314 PP11-332 The Role of Type I and Type III Interferons in Salmonella-infected HIV Infection Leads to Increased Proliferation of T-cells by Two Distinct Christopher Dendritic Cells. Taija E. Pietilä, Pamela Österlund, and Ilkka Julkunen, Pathways that Differentially Affect CD4 and CD8 T-cells. Department of Viral Diseases and Immunology, National Public Health Wilhelm, Michele Di Mascio, Zonghui Hu, Sharat Srinivasula, Vishakha Institute, Helsinki, Finland. Thaker, Joseph Adelsberger, Adam Rupert, Michael Baseler, Yutaka Tagaya, Gregg Roby, Catherine Rehm, Dean Follmann, Clifford Lane and PP10-315 Marta Catalfamo, CMRS/Laboratory of Immunoregulation, NIAID, NIH, Activation of Interferon Response in Human PBMC by Avian Infl uenza Bethesda, MD. H5N1 Virus. Concetta Castilletti, Eleonora Lalle, Licia Bordi, Roberta Chiappini, Alessandra Sacchi, Maria Rosaria Capobianchi, Laboratory PP11-333 Manfred of Virology, National Institute for Infectious Diseases “Lazzaro Spallan- Oral Type 1 Interferon Protection from Lethal Infl uenza Virus. W. Beilharz and Alayne L. Bennett, Discipline of Microbiology and Im- zani”, Rome, Italy. munology, School of Biomedical, Biomolecular and Chemical Sciences, PP10-316 The University of Western Australia, 35 Stirling Hwy, Crawley, Perth, TOLLOME: A Web Based Knowledge Discovery Environment for Innate Australia. Immunity. Shamith Samarajiwa, Sam Forster, Katie Auchettl, Sarah Boyd, Paul Hertzog, Center for Innate Immunity and Infectious Diseases, PP11-334 Monash Institute of Medical Research, Monash University, Clayton, Pattern of Regulatory T-cell Migration in AE17 Tumour Bearing Mice Haydn T Kissick, Demelza J Ireland, Victoria, Australia. Following Tumour Challenge. Manfred W Beilharz, Discipline of Microbiology and Immunology, M310, PP10-317 School of Biomedical, Biomolecular and Chemical Sciences, The Univer- DNA Damage Response Activates Interferon Signaling. Sabrina sity of Western Australia, Crawley, WA, Australia. Brzostek, Chris Gordon, Sarah VanScoy, Nancy C. Reich, Department of Molecular Genetics & Microbiology, Stony Brook University, Stony PP11-335 Brook, NY. Proteome Profi ling of Multiple Myeloma and the Associated Microen- vironment in Bone Marrow. Christopher Gerner, Astrid Slany, Thomas PP10-318 Mohr, Josef D. Schwarzmeier, Christoph Zielinski, Johannes Drach, Identifi cation of TSLP-dependent Mediators in a Calcipotriol Mouse Karl Landsteiner Institute for Cytokine Research, Vienna, Austria. Model of Skin Infl ammation. Heidi K. Jessup and Michael R. Comeau, Infl ammation Research, Amgen, Inc. Seattle, WA. PP11-336 IP-10 and IL-1Ra elevation in cytomegalovirus-infected vs normal PP10-319 midtrimester amniotic fl uids. Sharon S.W. Chow, Beverley Hall, Cheryl Upregulation of IL-15 Gene Expression in Human Monocytic Cells by A. Jones, Maria E. Craig, Jacki Catteau, Andrew R. Lloyd, William D. HSV-1 is Mediated by TLR2 Signalling. R. Ahmad, S. El Bassam, P. Cor- Rawlinson, School of Medical Sciences, University of New South Wales; deiro, J. Menezes, Ste-Justine Hospital Research Center and Depart- Virology Research, POWH & UNSW Research Laboratories, Prince of ment of Microbiology & Immunology, Faculty of Medicine, University of Wales Hospital; Department of Microbiology, SEALS, Prince of Wales Montreal, Montreal, QC. Hospital. PP10-320 PP11-337 Mechansim of PML-induced Senescence. Mathieu Vernier, Veronique The TGF-β Superfamily Cytokine MIC-1 Causes Tumour-induced An- Bourdeau, David Baudry, Gerardo Ferbeyre, Department of biochemis- orexia/Cachexia by Modulating Appetite Control Centres in the Hypo- try, University of Montreal, Montreal, QC. thalamus. Samuel N Breit, Heiko Johnen, Shu Lin, Tamara Kuffner, David PP 11 – CYTOKINES IN PRECLINICAL MODELS OF CANCER A Brown, Vicky Wang-Wei Tsai, Asne R Bauskin, Liyun Wu, Eva Corey, AND INFECTIOUS DISEASE Amanda Sainsbury, Herbert Herzog, Centre for Immunology, St Vincent’s Hospital and University of NSW, Australia. PP11-329 CCL5 Promotes Breast Cancer Proliferation Through mTOR/4E-BP1 PP11-338 Dependent mRNA Translation. Thomas T. Murooka, Ramtin Rahbar and Studies on Interleukin-21 Production in HIV-infected/AIDS Patients: Eleanor N., Toronto General Research Inst. & University of Toronto, A Potentially New Biomarker for AIDS Progression. Alexandre Iannello, Toronto, Canada; McGill University, Montreal, Canada; Northwestern Cecile Tremblay, Jean-Pierre Routy, Mohamed-Rachid Boulassel, University School of Medicine, Chicago, USA. Emil Toma and Ali Ahmad, Laboratory of Innate Immunity, Ste-Justine Hospital Research Center; Department of Microbiology & Immunology, PP11-330 University of Montreal, Montreal, QC. Prevention of Azoxymemethane/Dextran Sodium Sulfate-induced Colon Carcinogenesis by CCR2 Blockade. Naofumi Mukaida, Feodora I. Kosta-
42 Cytokines Montreal 2008 Wednesday, October 15, 2008
PP11-339 Campbell, School of Molecular and Microbial Biosciences, University Toll-like Receptor Mediated Innate Immune Response in Hepatocytes of Sydney, Sydney, NSW, Australia Suppressed Woodchuck Hepatitis Virus Replication Via Interferon- PP12-356 Xiaoyong Zhang, Zhongji Meng, Yang Xu, Jörg independent Pathway. Differential Actions of GP130 Cytokines: Mechanisms of Oncostatin M Schlaak, Michael Roggendorf, Mengji Lu, Institute of Virology, University Functional Specifi city. Nick Underhill-Day and John K. Heath, College of Hospital of Essen, Essen, Germany; Department of Microbiology, Tongji Life and Environmental Sciences, School of Biosciences, University of Medical College, Huazhong University of Science and Technology, Birmingham, Birmingham, UK. Wuhan, China. PP12-357 PP11-340 MGBP-2 Inhibits RAC Activation by Platelet-derived Growth Factor or Effects of Interferon-alpha on Regulatory T-cell Depletion in Cancer Integrin Engagement: Possible Role of Phosphatidylinositol 3-kinase. Shawna Wall, Duane Jeansonne, Pei-Yi Lin, Aijie Liu, Immunotherapy. Angela F. Messmer, Sujata Balasubramanian, and Deborah J. Vestal, Gaby Rennebeck, Suzanne Thibodeaux, Carolina Livi, Ben Daniel, Tyler Department of Biological Sciences, University of Toledo, Toledo, OH. Curiel, Department of Medicine, Cancer Therapy & Research Center at the University of Texas Health Science Center, San Antonio, TX. PP12-358 Molecular Cloning and Functional Studies of Atlantic Salmon Mito- PP11-341 chondrial Antivrial Signaling Protein. Silje Lauksund, Tina Svingerud, Cell-associated IL-15 is the Mediator of Tumor Immunity in B16ALPHA Veronica Bergan, Øyvind Kileng and Børre Robertsen, Department of Tzu G. Wu, Theresa K. Umhoefer, Jade Cao, Robert J. Vaccine Cells. Marine Biotechnology, Norwegian College of Fishery Science, University Burgmeier, Christine F. Grewe, Michael R. DeWall, Alexander T. Burton, of Tromsø, Norway. Michael J. Gerger, Molly C. Schwab, and W. Robert Fleischmann, Jr., The University of Minnesota Medical School, Minneapolis, MN. PP12-359 A Novel Mechanism for the Regulation of GAB1 Recruitment to the PP11-342 α β Plasma Membrane. René Eulenfeld, Fred Schaper, Department of Bio- The Impact of IFN 2 on Signaling of STAT1, STAT3, STAT5a, STAT5b, chemistry, RWTH Aachen University, Aachen, Germany. and SOCS3 in Clinical Melanoma Precursors, the Atypical NEVI. Wenjun Wang, Ling Chen, Arash Radfar, John M Kirkwood, Division of PP12-361 Hematology and Oncology, Department of Medicine, School of Medi- Characterization of the Bovine Type I Interferon Locus. Angela Walker cine, University of Pittsburgh, Pittsburgh, PA. and R. Michael Roberts, Department of Veterinary Pathobiology, Univer- sity of Missouri, Columbia, MO. PP11-343 Effi cacy of Human Recombinant Interferon-α2b (VIFERON®) in Treat- PP12-362 ment of Neonatal Bacterial and Viral Infections. Marina V. Degtyareva, WNTS as a New Kind of Cytokines. Jing-pu Zhang, Bin Hong and Yuan Irina G. Soldatova, Ekaterina G. Getya, Nikolay N. Volodin, Nina V. Var- Yang, Institute of Medicinal Biotechnology, Chinese Academy of Medical tanian, Valentina V. Malinovskaya, Department of Neonatology, Russian Sciences. State Medical University, Moscow, Russia. PP12-363 PP11-344 What do Cytokine Polymorphisms Tell Us About Human Population Down-regulation of CXCL-1 Inhibits Growth of Colorectal Liver Metas- History? The Case of European Populations. Fabian A. Crespo, Rafael tases. Obul R Bandapalli, Stephan M Goeppinger, Matthias Gaida, Moritz Fernandez-Botrán, Manuel F. Casanova, Rachel Oberst and Christopher Wente, Peter Schirmacher and Karsten Brand, Institute of Pathology R. Tillquist, Department of Pathology and Laboratory Medicine, Univer- and Department of Surgery, University Clinic Heidelberg, University of sity of Louisville, Louisville, KY. Heidelberg, Im Neuenheimer Feld 220/1, D-69120 Heidelberg, Germany. PP12-364 PP11-345 Single Nucleotide Polymorphisms of TNFα Gene and its Receptors Gentically Engineered Oncolytic Vesicular Stomatitis Virus to Stimulate 1 and 2 in Mexican Lepromatous Leprosy Patients. Margarita Mon- Anti-tumor Immune Response. Simon Leveille and John Hiscott, Molecu- toya-Buelna, José F. Muñoz-Valle, Anabell Alvarado-Navarro, Rocio I. lar Oncology Group, Lady Davis Institute, McGill University, Montreal, López Roa, Luis E. Figuera-Villanueva, Mary Fafutis-Morris, Centro de QC. Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, México. PP 12 – SIGNAL TRANSDUCTION II PP12-365 PP12-346 Genomic Analysis of the Equine Type I Interferon Family. Eva Wattrang, Promoter Insertion Reveals Lysine Demethylase FBXL11 as a Negative Bettina Wagner and David A. Morrison, Department of Virology, κ Tao Lu*, Mark W. Jackson, Aatur D. Singhi, Eugene Regulator of NF B. Immunobiology and Parasitology, National Veterinary Institute, Uppsala, Kandel, Benlian Wang, Maojing Yang, Yi Zhang, Mark Chance, Masaru Sweden. Miyagi, Andrei V. Gudkov, and George R. Stark, Department of Molecu- lar Genetics, Lerner Research Institute, Cleveland Clinic Foundation, PP12-366 Cleveland, OH. The Production of Interferon-β Induced by HIV-1 Nef Treatment of Pri- ISICR Young Investigator Award mary Human Monocyte-derived Macrophages Requires the PI3K/AKT Pathway. Zulema A. Percario, Ilaria Gentile, Giorgio Mangino, Gianna PP12-353 Fiorucci, Giovanna Romeo, Elisabetta Affabris, Dept. of Biology, Univ. β Fang IL-17 Signaling Induces Sequential Phosphorylation of C/EBP . Roma Tre, Rome, Italy. Shen, Nan Li, Troy Wood, and Sarah L. Gaffen, Dept. of Oral Biology, Dept. of Chemistry, SUNY Buffalo, Buffalo NY. PP12-367 Ubiquitin-regulated Recruitment of IKKε to MAVS Interferon Signal- PP12-354 ing Adapter. Suzanne Paz, Myriam Vilasco, Meztli Arguello, Qiang Sun, The Impact of Defective GP130-SHP2/SOCS3 Signaling on the Astro- Judith Lacoste, Rongtuan Lin, Eliane F. Meurs, John Hiscott, Molecular Ricardo F. Frausto, Gareth Denyer, Jürgen cyte Response to Hyper-IL6. Oncology Group, Lady Davis Institute - Jewish General Hospital, McGill Scheller, Stefan Rose-John, Brendan J. Jenkins, Matthias Ernst, Iain L. University, Montreal, QC. Cytokines Montreal 2008 43 Wednesday, October 15, 2008
PP12-368 PP12-372 Anti-Infl ammatory Effect of Citrus Grandis Osbeck (DANGYUJA) Leaves A Novel Function of STAT3 in Cellular Respiration. Joanna Wegrzyn, in LPS-stimulated raw 2764.7 Cells. Eun-Jin Yang, Gyeong-Jin Kang, Ramesh Potla, Yong-Joon Chwae, Qifang Zhang, Marta Derecka, Karol Hye-Ja Lee, Sun-Soon Park, Weon-Jong Yoon, Hee-Kyoung Kang, So-Mi Szczepanek, Magdalena Szelag, Agnieszka Gornicka, Akira Moh, Kim and Eun-Sook Yoo, Department of Pharmacology, College of Medi- Shadi Moghaddas, Qun Chen, Santha Bobbili, Xin-Yuan Fu, Edward J. cine, Cheju National University, Jejudaehakno, Jeju, South Korea. Lesnefsky, Department of Immunology, Lerner Research Institute, The CYTOKINES AD?FINALPDF !- Cleveland Clinic Foundation, Cleveland,OH. PP12-369 NF-κB is Transported into the Nucleus Via A Subset of Importin α PP12-373 Molecules. Riku Fagerlund, Krister Melén, Xinmin Cao, Ilkka Julkunen, CK2 Positively Regulates Janus Kinase-signal Transducer and Activator Department of Viral Diseases and Immunology, National Public Health of Transcription Signaling by Interactions with Janus Kinases. Ying Institute, Helsinki, Finland. Zheng, Hongwei Qin, Etty Benveniste, Department of Cell Biology, Uni- versity of Alabama, Birmingham, AL. PP12-370 Cigarette Smoke Products Suppress Anti-viral Effects of Type I Inter- PP12-374 feron Via Phosphorylation-dependent Downregulation of its Receptor. Tick-borne Encephalitis Virus Proteins PRM and NS1 Act as Potent Wei-Chun Huang Fu, Jianghuai Liu, Ronald N. Harty and Serge Y. Fuchs, Inhibitors of Cytokine Gene Expression. Suvi Kuivanen, Pasi Kaukinen, Department of Animal Biology and Mari Lowe Center for Comparative Maarit Sillanpää, Nathalie Uzcátegui De Castillo, Antti Vaheri, Ilkka Oncology, University of Pennsylvania, Philadelphia, PA. Julkunen and Olli Vapalahti, Department of Virology, Haartman Institute, Faculty of Medicine, University of Helsinki, Helsinki, Finland. PP12-371 Virus-induced Unfolded Protein Response Attenuates Anti-viral Defenses Via Phosphorylation-dependent Ubiquitination and Degrada- 20:30 DREAMSCAPE GALA – WINDSOR STATION tion of Type I Interferon Receptor. Jianghuai Liu, Wei-Chun Huang Fu, K.G. Suresh Kumar, James P. Casey, Robert Hamanaka, Christina Grigo- riadou, Rafael Aldabe, J. Alan Diehl, and Serge Y. Fuchs, Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, Univeristy of Pennsylvania, Philadelphia, PA.
44 Cytokines Montreal 2008 Thursday, October 16, 2008
KEYNOTE LECTURE
08:00 KEY-2 30 Years After the Dawn of Cytokine Molecular Biology: Roles of IRF Transcription Factors. Tadatsugu Taniguchi, Department of Immunology, University of Tokyo, Japan.
PLENARY SESSION 4 LE GRAND SALON
CYTOKINE-BASED THERAPEUTICS
Chairpersons: Marc Feldmann, Kennedy Institute of Rheumatology (UK) Tadamitsu Kishimoto, Osaka University (Japan) 09:00 PL4-20 Basic and Clinical Studies Involving IL-6 Receptor Blockade: TH17 Cells and Aryl Hydrocarbon Receptor. Tadamitsu Kishimoto, Osaka University, Japan. 09:30 PL4-21 Blocking IL-1 in Auto-infl ammatory Diseases. Charles Dinarello, University of Colorado School of Medicine, Denver, CO. 10:00 PL4-22 Blockade of the Lymphotoxin-LIGHT Pathway and the Treatment of Autoimmune Disease. Evangelia Hatzis, Adrian Papandile and Jeffrey Browning, Biogen Idec, Cambridge, MA.
10:30 COFFEE BREAK – FOYER
11:00 PL4-23 Interferons in the Pathogenesis of Systemic Lupus Erythematosus. Mary K. Crow, Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY. 11:30 PL4-24 Treatment of Chronic Hepatitis B and C with Interferons. Lawrence M. Blatt, Alios BioPharma, South San Francisco, CA. 12:00 TBA
12:30 LUNCH BREAK – ON YOUR OWN
Cytokines Montreal 2008 45 Thursday, October 16, 2008
LATE BREAKING SESSION MARQUETTE
PATHOGENESIS AND THERAPY OF HEPATITIS B AND C VIRUS INFECTION
Chairpersons: Daniel Lamarre, Centre Hospitalier Université de Montréal (Canada) Santiago Duenas-Carrera, CIBG (Cuba) 14:00 LB-2 A Novel Innate Immune Antiviral Mechanism of Action of Ribavirin in Mammalian Cells Contributes to Effi cacy of Combination Therapy for Hepatitis C. Emmanuel Thomas, Zongyi Hu, Stephen Dong, Jordan J. Feld and T. Jake Liang, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD. 14:15 LB-54 A Soluble Form of the LDL Receptor Inhibits Hepatitis B Virus Replication in vitro. Ariel Werman, Brent E. Korba, Ben Alkahe, Danit Finkelshtein, Sergey Bujanover, Daniela Novick, Ernest Vinocour and Menachem Rubinstein, Dept. of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel. 14:30 LB-265 Early but not Late Interferon Alpha Therapy Against Hepatitis C Rescues Polyfunctional CD4+ and CD8+ Memory T-Cells. Mohamed S. Abdel-Hakeem, Nathalie Bédard, Gamal Badr, Mario Ostrowski, Julie Bruneau, Rafi ck P. Sékaly, Bernard Willems, Jenny E. Heathcote and Naglaa H. Shoukry, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CHUM), Hôpital St-Luc, Université de Montréal, Montréal, QC. 14:45 LB-178 Changes in Gene Expression induced by Pegintron Plus Ribavirin in PBMC of Hepatitis C Patients During the First 10 Weeks of Treatment. Milton W. Taylor, Takuma Tsukahara, Jeanette N. McClintick, Howard J. Edenberg, Paul Kwo, Department of Biology, Indiana University, Bloomington, IN. 15:00 LB-165 Higher Effi cacy of Peg-IFN-α2 Ribavirin combined therapy in HCV-infected patients with functional myeloid dendritic cells (MDC). Ian Gaël Rodrigue-Gervais, Hawley Rigsby, Bernard Willems and Daniel Lamarre, Centre Hospitalier de l’Université de Montréal; INSERM Unité 743, Hôpital Saint-Luc, Université de Montréal, QC. 15:15 LB-253 Hepatitis C Virus NS3/4A Protein Downregulates Toll-like Receptor 7 Signalling Pathway. Maarit Sillanpää, Pasi Kaukinen and Ilkka Julkunen, Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland.
46 Cytokines Montreal 2008 GeneralExhibition InformationPublic Transport – www.stm.info The exhibition will be open: Public transport is a great way to get around Montréal. Monday – Wednesday: 07:30 – 19:30 Notice those big blue signs with the white arrows? That’s Thursday: 07:30 – 10:30 the way to the city’s underground métro system—one Please use all breaks to visit the exhibition stands. of the safest in the world. The métro is fast and links all of downtown and major tourist destinations, as well as Badges connecting to Montréal’s frequent bus service and the Participants are asked to wear their name badges at train. You can purchase individual tickets, or convenient functions during the conference. one- or three-day passes for unlimited travel on bus and métro. If your trip requires both métro and bus, make Breakfast sure to get a transfer from the bus driver or in the métro A light breakfast (Coffee/Danish – “Breakfast on the Run”) station (the tall silver boxes once you’re inside the turn- will be served in the Foyer. stiles); transfers are valid for 90 minutes. The time that is Monday, Tuesday and Wednesday: 7:30 – 8:30 printed on it indicates when the validity period will end. Fares: Coffee Breaks Adult fare (bus and métro): $2.75, 6 tickets: $12.00. Coffee/Tea/Water will be available in the Foyer Monday, Tuesday, and Wednesday The metro and bus Tourist Card: Morning Coffee Breaks: 10:30 – 11:00 1 day, $9.00; 3 days, $17.00. Afternoon Coffee Breaks: 16:00 – 16:30 Offi cial Carrier Lunch Air Canada is the offi cial airline carrier of Lunch break is “On Your Own” from 12:30 to 14:00. You Cytokines 2008. Discount rates are available can fi nd several restaurants and coffee shops in Place from Air Canada on most routes. A promo- Ville Marie in the Underground City (map of the Under- tion code will be provided along with your ground and a list of restaurants are provided with the acknowledgement of registration. Program Book). Members of the Organizing Staff will be available in the Foyer to assist you. Shopping ONE OF THE GREAT SHOPPING CITIES OF THE WORLD Parking – FIND OUT FOR YOURSELF Parking is available in the Metropolitan Parking garage Many major retail and specialty shops can be found on located on the lower level, adjacent to the hotel (look for Saint Catherine St West. Most stores are open from 9 or a green P sign). Indoor valet parking is also available at 10 am to 6 pm Monday through Wednesday, to 9 pm on the Queen Elizabeth Hotel. Thursday and Friday, and 9 or 10 am to 5 pm on Satur- day. Many stores are now also open on Sunday from Bank noon to 5 pm. Opening hours: Monday to Wednesday: 10:00 to 16:00, on Thursday: 10:00 to 20:00, and on Friday: 10:00 to Insurance, Liability 16:00; 24 hours automated cash dispensers are located Neither the organizers nor Fairmont Queen Elizabeth outside most banks. can be held responsible for any personal injury, loss, damage, accident to private property or additional Currency and Credit Cards expenses incurred as a result of delays or changes in The currency is in Canadian dollars. Most hotels, restau- air, rail, sea, road or other services, strikes, sickness, rants and shops accept internationally valid credit cards. weather, acts of terrorism and any other cause. All participants are encouraged to make their own Language arrangements for health and travel insurance. English is the offi cial language of the conference. No simultaneous translation will be provided.
Cytokines Montreal 2008 47 Social Program Opening Session – Welcome Reception Sunday, October 12, 2008 20:30h in the Hochelaga rooms Dress Code: Casual All registered delegates and their accompanying persons are invited to attend the offi cial Opening Ceremony, to be followed by a Welcome Reception with a buffet dinner at the Fairmont Queen Elizabeth Hotel.
Evening at the Notre Dame Basilica of Montreal Monday, October 13, 2008 19:30h Meeting point at the hotel lobby of the Fairmont Queen Elizabeth Hotel. Included in the registration fee for participants and registered accompanying persons. Dress Code: Casual A special showing of “And Then There Was Light” —a light and sound spectacular at the historic Notre Dame Basilica in Old Montreal, followed by an exclusive organ recital by Pierre Grandmaison. The show recreates the history of Montreal and the Basilica; through the magic of fi lm projections, lighting and illustrations, you will relive a history fi lled with challenges and spectacular success. Additional information is available at the website www. therewaslight.ca. The capacity of the Basilica is 300, and therefore it is necessary to reserve a spot for the program. A complimentary ticket for the evening at Notre Dame Basilica is provided to each registrant of Cytokines 2008 who signs up for the light show; additional tickets for a spouse and/or guest(s) may be purchased at the cost of $20 per person. Please note that tickets are available on a “fi rst come-fi rst serve” basis.
*Since the number of available places is limited, please be sure to register for this event.
Evening at the Montreal Museum of Fine Arts Tuesday, October 14, 2008 19:30h Meeting point at the hotel lobby of the Fairmont Queen Elizabeth Hotel. Included in the registration fee for participants and registered accompanying persons. Dress Code: Casual The Montreal Museum of Fine Arts will be holding an Andy Warhol Retrospective—that includes unique pieces from public and private collections. We have reserved the Glass Court at the Musée des Beaux Arts for delegates and guests of the Conference. The Museum is located at 1380 Sherbrooke St. West (corner of rue Crescent), a convenient 10-15 minute walk from the Fairmont Queen Elizabeth Hotel.
48 Cytokines Montreal 2008 No other artist is as completely identifi ed with Pop Art as Andy Warhol. The media called him the Prince of Pop. Warhol made his way from a Pittsburgh working class family to an American legend. He studied commercial art at the Carnegie Institute of Technology in Pittsburgh; after graduation in 1949, he went to New York to work as an illustrator for magazines like Vogue and Harper’s Bazaar. He soon became one of New York’s most sought after and successful commercial illustrators. In the sixties Warhol started painting daily objects of mass production like Campbell Soup cans and Coke bottles, quickly becoming a famous fi gure in the New York art scene. From 1962 on, he started making silkscreen prints of famous personalities like Marilyn Monroe and Elizabeth Taylor. The quintessence of Andy Warhol art was to remove the difference between fi ne arts and the commercial arts used for magazine illustrations, comic books, record albums or advertising campaigns. Warhol once expressed his philosophy in one poignant sentence: “When you think about it, department stores are kind of like museums”. In the 1970s, the philosopher of art produced individual portraits of the rich and affl uent of his time—Mick Jagger, Michael Jackson and Marilyn Munroe. Over time, Warhol’s activities became more entrepreneurial. In 1975 Warhol published The philosophy of Andy Warhol. In this book he describes what art is: “Making money is art, and working is art and good business is the best art.” A complimentary ticket for the evening at Musée des Beaux Arts is provided to each registrant of Cytokines 2008; additional tickets for a spouse and/or guest(s) may be purchased at the cost of $20 per person.
Gala Dinner Wednesday, October 15, 2008 20:00h at Windsor Station Dress Code: Evening Dress Included in the registration fee for participants and regis- tered accompanying persons. All registered delegates and their accompanying persons are invited to attend the Gala Dinner. A Gala Dinner has been organized in the heritage Windsor Station which will be transformed into a magical Dream- scape. Created by Mina Martini Events and Promotions, this unforgettable evening of entertainment will include music, dance and gravity defying acrobatics.
Cytokines Montreal 2008 49 GO TAKE A HIKE: A Walking Tour of Downtown
From that offi ce, go back to the other end of the square and turn left (east) on: Rue University 5. Boulevard René-Lévesque: Formerly Dorchester Boulevard, this primary street was Fairmont Queen renamed in 1988 following the death of René- Elizabeth Boulevard René-Lévesque O Lévesque, the Parti Quebecois leader who led Rue MansfieldRue Belmont Gauchetière O the movement in favor of Québec indepen- Rue de la Cathédrale dence and the use of the French language. Rue de la Boulevard René-Lévesque is the city’s broad- est downtown thoroughfare, and the Start one with the fastest traffi c. On the right is the: 1. 1000 rue de la Gauchetière: This young contribution to the already- 6. Cathédrale Marie-Reine-du-Monde (Mary Queen of the World memorable skyline is easily identifi ed Cathedral): Built between 1875 and 1894 as the headquarters for by its copper-and-blue pyramidal top, Montréal’s Roman Catholic bishop, the cathedral is a copy of St. which rises to the maximum height Peter’s Basilica in Rome, built to roughly one-quarter scale. The permitted by the municipal building statue in front of the cathedral is of Bishop Ignace Bourget (1799- code. Inside, past an atrium planted 1885), the force behind the construction of the basilica. It was with live trees, is a huge indoor skat- sculpted in 1903 by Louis-Philippe Hébert, who is also responsible ing rink bordered by cafes with seat- for the statue of de Maisonneuve in the Place d’Armes in Vieux- ing for more than 1,500 spectators. Montréal. Walk west for 1 block on rue de la Continue past the cathedral and Gauchetière. On the left is: cross rue Mansfi eld, and you will see: 2. Le Marriott Château Champlain: The hotel’s distinctive facade of half- 7. Fairmont The Queen Elizabeth moon windows inspired its nickname: (Le Reine Elizabeth): Opened in the “Cheese Grater.” 1958, Montréal’s largest hotel stands above Gare Centrale, the Turn right on rue Peel, walking north. When main railroad station, making it you hit boulevard René-Lévesque, bear right most convenient for people arriving by and you’ll arrive at: train. It also has direct access to the un- derground city, and buses leave for Dorval 3. Square Dorchester: The square’s tall old and Mirabel airports from here. trees and benches invite lunchtime brown-bag- gers. This used to be called Dominion Square, Across boulevard René-Lévesque from but it was renamed for Baron Dorchester, an Fairmont Le Reine Elizabeth hotel is: early English governor, when the adjacent street, once named for him, was changed to 8. Place Ville-Marie: Known as PVM to boulevard René-Lévesque. Along the east side Montrealers, this massive structure was of the square is the Sun Life Insurance build- the gem of the postwar urban redevelop- ing, built in three stages between 1914 and ment efforts in Montréal. The skyscraper, 1931, and the tallest building in Québec from with its cross-shaped fl oor plan, was designed by I. 1931 until the skyscraper boom of the post- M. Pei. It is meant to recall Cartier’s cross, planted World War II era. This is a gathering point for on Mont-Royal to claim the island for France, and tour buses and calèches. In winter, the calèche for de Maisonneuve’s fi rst little settlement, Ville-Ma- drivers replace their carriages with sleighs and rie. The complex, completed in 1962, has a fountain give rides around the top of Mont-Royal. in its plaza called Feminine Landscape (1972), executed by Toronto artist Gerald Gladstone. At the northeast corner of the square is the main offi ce of: At the end of the hotel, turn left along rue Université, crossing boulevard René-Lévesque and walking 2 4. Infotouriste Centre: Many useful maps and blocks to rue Ste-Catherine. Turn right on rue Ste- brochures are in stock here, most of them Catherine and walk past avenue Union, where you’ll free for the taking. Visitors can ask questions see: of bilingual attendants, purchase tour tickets, change money, make hotel reservations, con- 9. Carré Phillips: This plaza contains a statue of nect with the Internet, and rent a car. Edward VII and, during much of the year, a farm stand selling Québec maple products.
50 Cytokines Montreal 2008 Over to the left, across rue Ste-Catherine, is: Continue up rue Crescent, past boulevard de Maisonneuve, to the corner of rues Crescent and Sherbrooke. On this left corner, and on 10. Cathédrale Christ Church: Built from 1856 to 1859, this neo- the opposite side of Sherbrooke, is the: Gothic building is the seat of the Anglican bishop of Montréal. The church garden is modeled on a medieval European cloister. 14. Musée des Beaux-Arts (Museum of Fine Arts): This is Canada’s The cathedral donated the land on which place de la Cathédrale oldest and Montréal’s most prominent museum. The modern annex and the shopping complex underneath it, Prom- was added in 1991 and is connected to the original enades de la Cathédrale, were built, in return for stately Beaux Arts building (1912) across the way eventual ownership of the skyscraper and the by an underground tunnel that doubles as a gallery. underground complex. All those subterranean Both buildings are made of Vermont marble. corridors and levels have caused some to dub it the “fl oating” or “fl ying” church. Turn right on rue Sherbrooke, passing, at the next corner, the Holt Renfrew department store, identi- Turn left on: fi ed on its marquee only as HOLTS. Continue on rue Sherbrooke, passing, on the right, the: 11. Rue Ste-Catherine: Head west through the center of Montréal’s shopping district. Many of 15. Maison Alcan: This structure has been fre- Montréal’s department stores are along here, in- quently lauded for its incorporation of 19th-century cluding, to the right of the church, La Baie (or “The houses into its late-20th-century facade. Step inside Bay,” short for Hudson’s Bay Company, successor the lobby to see the results, especially over to the to the famous fur-trapping fi rm). Movie houses, right. cafes, shops, and several “adult” emporia line rue Ste-Catherine for several blocks. Walk 4 more blocks in the same direction. On the opposite side of rue Sherbrooke is the entrance to: At the corner of rue de la Montagne is: 16. McGill University: The gate is usually open to this, Canada’s 12. Ogilvy: This is the most vibrant of most prestigious university. Step inside and see, just to the left, a classy breed of department store a large stone that marks the site of the Amerindian Horchelaga that appears to be fading from the settlement that existed here before the arrival of the Europeans. scene. Founded in 1866, it strives to maintain its upmarket stature by blend- Also on the campus is the: ing tradition with tasteful marketing 17. Musée Redpath: Housed in a building dating from 1882, this strategies. Its Christmas windows are museum’s main draw is its Egyptian antiquities collection, the eagerly awaited each year. A bagpiper second largest of its kind in Canada. announces the noon hour. Opposite the university, and just half a block south of rue Sherbrooke, on the left, is a Continue 1 more cream-colored resin sculpture called: block to: 18. The Illuminated Crowd (1979): Raymond 13. Rue Crescent: This Mason’s sculpture is frequently photographed and nearby streets and widely admired for its evocation of the are the locus of the human condition, although its detractors fi nd center-city social it sentimental and obvious. Circle it at leisure and dining district, and then return to rue Sherbrooke, turning largely yuppie Anglo right. in character, if not necessarily in strict One block east on rue Sherbrooke is the: demographics. Pricey boutiques, inexpensive pizza joints, upscale restaurants, and dozens of bars and 19. Musée McCord: This private museum of Canadian dance clubs draw enthusiastic consumers looking to history fi rst opened in 1921 and was substantially spend money and party the night away. This center of renovated and expanded in 1992. Named for its founder, gilded youth and glamour was once a run-down slum David Ross McCord (1844-1930), the McCord has area slated for demolition. Luckily, buyers with a good an eclectic and often eccentric collection of 80,000 aesthetic sense saw the possibilities of these late-19th- artifacts. Furniture, clothing, china, silver, paintings, century row houses and brought them back to life. photographs, and folk art reveal elements of city and rural life from the 18th to the 20th century. Amerindians Turn right on rue Crescent and: are represented in the First Nations room. Take a Break – Lively spots for coffee or snacks are To return to the Fairmont Queen Elizabath Hotel con- abundant along rue Crescent. Thursday’s (no. 1449, in tinue east on rue Sherbrooke to rue University, then L’Hôtel de la Montagne) is one, if you can fi nd a seat on turn right (south) and walk down to boulevard René-Lévesque. the balcony, or walk a little farther up rue Crescent and get The hotel is a half block to your right. a sidewalk table at Sir Winston Churchill Pub (no. 1459).
Cytokines Montreal 2008 51 MAKE THE MOST OF EVERY CELL
52Cytokines_show_Outline.indd Cytokines Montreal 2008 1 8/12/08 10:07:05 AM bringingbringing healthhealth toto lifelife
NATIONAL PUBLIC AND MEDIA RELATIONS FOR • treatments and diagnostics targeting inflammatory proteins • building bridges with stakeholders in immunotherapies
TORONTO MONTRÉAL VANCOUVER Joan Lister Gabrielle Collu Ann Gibbon 1-888-773-7784 (222) 1-888-773-7784 (226) 1-888-773-7784 (223) [email protected] [email protected] [email protected]
www.healthcomm.ca
Cytokines Montreal 2008 53 Merck Frosst contributes to the health of Canadians
Over the past century, we have discovered some of the most important medicines and vaccines of our time.
In 2007, Merck Frosst invested close to $110 million in R&D in Canada. More than 300 of the world’s leading scientific personnel work at the Merck Frosst Centre for Therapeutic Research, one of the largest biomedical research facilities in Canada.
You work hard. You play hard. We do too. We understand just how passionate you are as a scientist and as a person. PBL InterferonSource is committed to providing reliable, high- quality interferon products. Our focus will help you in advancing your research... and give you time to leap tall buildings in a single bound.
[T] +1-732-777-9123 [F] +1-732-777-9141 [E] [email protected] [W] www.interferonsource.com
54 Cytokines Montreal 2008 ADVANCING SCIENCE FOR BETTER HEALTH
Our scientists are all alike. Unique.
Anthony is a leader in MedImmune’s inflammatory disease research group.
For more information on MedImmune and career possibilities, visit www.medimmune.com or www.cambridgeantibody.com (Cambridge-based positions).
For more information please contact Robert L. Bencher | Director Rules-Based Medicine, Inc. 3300 Duval Road · Austin, Texas 78759 P 215 806 1747 · Toll-free 866 RBM MAPS (726 6277) F 512 835 4687 · [email protected] www.rbmmaps.com
the biomarker testing laboratory
Cytokines Montreal 2008 55 R&D Systems Tools for Cell Biology Research™ R&D Systems Quantikine® ELISA Kits The standard by which immunoassays are measured. Simplify your
Where do you get your cytokine research TM. immunoassays? More scientists trust with Assay Designs R&D Systems for accurate > Easy-to-use kits & reagents and dependable results. > Large cytokine product portfolio Each Quantikine ELISA kit -after-lot is fully validated, ready > Reproducible results lot to run, and quality tested. IL-1B IL-8 Specificity Reproducibility IL-6 IL-21 Accuracy Reliability IL-4 IL-22 Sensitivity A IFN-G TNF- For results you can trust.
View our complete portfolio of cytokines & chemokines at www.AssayDesigns.com Selection expanding weekly— visit www.RnDSystems.com/go/request to sign up for weekly new product updates.
www.cedarlanelabs.com
An ISO 9001:2000 and ISO 13485:2003 registered company. Now Over 800 Suppliers!
Reduce... Freight charges, Administration. Eliminate... Currency ConsolidateConsolidate exchange, Shipping and TMTM clearance issues. && SaveSave !! Receive... Rapid delivery, Access to a myriad of international products and suppliers. In CANADA: Toll Free: 1-800-268-5058 4410 Paletta Court, Burlington, ON L7L 5R2 ph: (289) 288-0001, fax: (289) 288-0020 e-mail: [email protected]
56 Cytokines Montreal 2008 540 tests results in under 3 Hours..with Biochip Array Technology
Cytokine & Growth Factors Array Biochip Array Technology is based on ELISA principles of competitive, sandwich and antibody capture assays
• Cytokine & Growth Factors Array simultaneously and quantitatively detects 12 cytokines and growth factors in a single sample • Small sample volume - 8µl per test, suitable for human serum and plasma sample • Ready to use biochips • Inter and intra assay CV’s typically less than 10%
Biochip Array Technology provides simultaneous multi-analyte testing and offers Time saving, Cost saving and an extensive Test Menu
Cytokine & Growth Factors Array I Cytokine IV
Interleukin-1 alpha (IL-1_) STNFR1 Interleukin-1 beta (IL-1`) STNFR2 Interleukin-2 (IL-2) SIL - 6R alpha Interleukin-4 (IL-4) MMP - 9 Interleukin-6 (IL-6) SIL - 2R alpha Interleukin-8 (IL-8) Interleukin-10 (IL-10) Vascular Endothelial Growth Factor (VEGF) Tumour Necrosis Factor-alpha (TNF-_) Interferon-gamma (IFN-a) Epidermal Growth Factor (EGF) Monocyte Chemotactic Protein-1 (MCP-1) Further cytokine assays in development
Randox Laboratories Ltd., 55 Diamond Road, Crumlin, Co. Antrim, United Kingdom, BT29 4QY t: +44 (0) 28 9442 2413, f: +44 (0) 28 9445 2912, e: [email protected] www.randox.com 2007
Welcome to a more colorful worldSM Value Through Innovation Introducing BD Horizon™ premium reagents
“Our driving ambition is to discover New BD Horizon V450 violet laser reagents and develop new and better medicines. We will achieve this by leveraging Introducing a new family of high-quality reagents from BD Biosciences, the most powerful technologies, engineered for exceptional sensitivity and consistency, and optimized for BD FACS™ flow cytometers equipped with violet lasers. but central to our success will be Visit bdbiosciences.com/colors to learn more. talented and resourceful people.”
This product is for Research Use Only. Not for use in diagnostic or therapeutic procedures. BD Biosciences BD, BD Logo and all other trademarks are property of 2350 Qume Drive Becton, Dickinson and Company. © 2008 BD San Jose, CA 95131 23-10361-00 bdbiosciences.com
Cytokines Montreal 2008 57 Curious Minds Roche is a broad spectrum supplier of high quality products for life science research. In addition to being a leader in instruments and systems, we also offer a complete list of reagents and kits. Discover an environment sure to satisfy your quest for knowledge
Located adjacent to Stanford University in the vibrant biotech environment of Silicon Valley, Schering-Plough Biopharma was built by legendary innovators. Combining research strengths in oncology and immunology, there is a legacy of pioneering science at Schering-Plough Biopharma that is being translated into medicines for our future.
At Schering-Plough Biopharma, you will join scientists who share your Visit us at the Roche booth and receive a free gift! passion and respect your opinion. Working in a close-knit environment, Julie Desnoyers, Account Executive with all the power, reach and resources of Schering-Plough Corporation, 1-800-667-2547, ext. 2736 or [email protected] you will face new challenges and discover what it means to be on the www.roche-applied-science.com leading edge of innovation.
Careers available in: UÊ ÃVÛiÀÞÊ,iÃi>ÀV UÊ Ý«iÀiÌ>Ê*>Ì }ÞÊ UÊ *ÀÌiÊ }iiÀ}Ê & Pharmacology & Antibody Technology UÊ >>ÞÌV>ÊEÊ*ÀÌiÊ iÃÌÀÞ
Schering-Plough Biopharma is an Equal Opportunity Employer. For more information, visit our website: www.schering-plough.com www.roche-applied-science.com
Fluorospot - The bright way to detect cells secreting multiple cytokines A simple and sensitive assay similar to ELISpot enabling you to detect cells secreting multiple cytokines in one well. Useful when studying cellular co-expression patterns, polyfunctional T cells and when samples are limited. Visit us at our booth for more information about the Fluorospot technique and our range of kits.
www.mabtech.com
58 Cytokines Montreal 2008 Commitment to Innovation
Use the solution that fits YOUR requirements
UÊConventional ELISA UÊMultiple Analyte At Abbott Bioresearch Center (ABC) in UÊInstant ELISA Detection – Worcester, we’re making new discoveries UÊHigh Sensitivity ELISA FlowCytomix every day. We’re innovating and developing Contract Development the medicines that change the world of patient UÊMatched Antibody Pairs UÊ health. ABC is a unique facility housing about 700 employees engaged in both research … for the Analytes in YOUR Research Field! and manufacturing. UÊAdhesion Molecules If you’re passionate about improving the Give us a try! health of people and contributing meaningfully UÊAnnexin V to your community, visit the career section of UÊApoptosis US: +1 866 952 2112 abbott.com and select #57170BR to learn UÊCD Markers EU: +43 1 796 more about how Abbott can change countless UÊChemokines lives...Starting with your own. UÊCytokines/Growth Factors 40 40-0 www.Abbott.com UÊTumor Biology
An EOE, we are committed to employee diversity. www.bendermedsystems.com
Stress-free cell separation for you and your cells The Biomarker Testing Laboratory: VISIT US Quality Assured AT BOOTH 16 OR ROBOSEP.COM
For more information please contact Robert L. Bencher | Director
3300 Duval Road Austin, Texas 78759 Phone: 215-806-1747 Toll-free 866-RBMMAPS (726-6277) www.rbmmaps.com [email protected]
Cytokines Montreal 2008 59 promouvoir la vie par la santé
RELATIONS PUBLIQUES ET RELATIONS MÉDIAS • Promotion des traitements et des méthodes diagnostiques ciblant les protéines inflammatoires • Création de liens avec les parties prenantes en immunothérapie
TORONTO MONTRÉAL VANCOUVER Joan Lister Gabrielle Collu Ann Gibbon 1-888-773-7784 (222) 1-888-773-7784 (226) 1-888-773-7784 (223) [email protected] [email protected] [email protected]
www.healthcomm.ca
60 Cytokines Montreal 2008 Your FIRST choice for cytokine reagents 5I t *-" t *-'New Stop by booth #11 t *-"'New for a chance to win t *- an iPod touch. 5I5I t *- t *-New t *-New t 54-1New *OOBUF*NNVOJUZ t (.$4'New t *'/αNew t *'/α t *-
For a complete listing of antibodies, recombinant proteins and immunoassays for the targets listed above please visit our website. XXXFCJPTDJFODFDPNt
A Canadian distributor since 1986, Medicorp Inc. now represents over 35 companies from the U.S. and Europe.
Biosource Int. Reagents in Immunology and Signal Transduction Mobio Laboratories DNA and RNA extraction & purification Kits Vaccination is one of the most cost-effective and successful of public health interventions. It has been used to tackle diseases such Jackson Immunoresearch as rabies, diphtheria, tetanus, yellow fever and, more recently, polio, Secondary Antibodies measles, mumps, and rubella and hepatitis B. Labvision In the past, vaccination was aimed mostly at the young. Today it can Over 2000 antibodies and reagents for be used for people of all ages with a range of vaccines available to prevent disease at all stages of life. Immunohistochemistry
Victories and challenges IDS Vaccines have helped to bring many diseases under control. Immunodiagnostic kits for Bone Marker Examples are poliomyelitis, measles and smallpox. Biochain However, many diseases are still not preventable by vaccination. DNA, RNA and protein from tissues and tools Our search continues for vaccines to prevent some of the world’s most common diseases such as cancer, HIV/AIDS and malaria. for biomedical research And more...
Contact us for Phone: 877-733-1900 (Toll Free) Fax: 800-361-8309 (Toll Free) more information: Email: [email protected] Web: www.medicorp.com
Cytokines Montreal 2008 61 PFIZER AU CANADA
Pfi zer Canada Inc. est la fi liale canadienne de Pfi zer Inc, première entreprise pharmaceu- tique à l’échelle mondiale, et elle est située à Kirkland, au Québec. Pfi zer découvre, met au point, fabrique et commercialise des médicaments d’ordonnance pour les humains et les animaux. Pfi zer Inc investit plus de sept milliards de dollars américains par année dans la recherche et le développement pour découvrir et mettre au point des médicaments d’importance vitale ou qui améliorent la qualité de la vie dans divers domaines thérapeu- tiques. Le siège social mondial de la Société se trouve à New York, où elle a été fondée en 1849.
Durant la Seconde Guerre mondiale, Pfi zer est devenue le premier fabricant de pénicilline à l’échelle industrielle, ce qui l’a propulsée dans l’ère moderne de l’industrie pharmaceutique. Pfi zer Canada possède maintenant une Division des marchés spécialisés, dont l’objectif est de faire progresser les connaissances scientifi ques sur les maladies qui se rapportent aux domaines de l’oncologie, du VIH, des maladies infectieuses, de l’endocrinologie et de l’ophtalmologie. À l’heure actuelle, l’oncologie est le premier secteur de recherche en importance pour ce qui est de la somme investie en recherche et développement.
Pfi zer Canada, qui est un chef de fi le en matière de recherche sur les soins de santé, a investi plus de 137 millions de dollars dans les travaux de recherche et de développement, les contributions et les partenariats en 2007. Depuis 2000, la Société a injecté plus d’un milliard de dollars dans la recherche-développement. Fière de fi gurer parmi les membres du Programme des entreprises généreuses d’Imagine Canada, Pfi zer Canada est l’une des principales sociétés donatrices du pays. Grâce à son programme d’engagement commu- nautaire, Pfi zer Canada a contribué à plus de 1 400 projets et organisations sans but lucratif partout au pays, versant au total plus de 25 millions de dollars, en 2007.
Pour obtenir de plus amples renseignements, visitez le site www.pfi zer.ca.
62 Cytokines Montreal 2008 PFIZER IN CANADA
Pfi zer Canada Inc. is the Canadian operation of Pfi zer Inc, the world’s leading pharmaceutical company and is located in Kirkland, Quebec. Pfi zer discovers, develops, manufactures and markets prescription medicines for humans and animals. Pfi zer Inc invests more than US$7 billion annually in R&D to discover and develop innovative life-saving and life-enhancing medicines in a wide range of therapeutic areas. Global headquarters are located in New York City, where the company was founded in 1849.
During the Second World War, Pfi zer became the fi rst company to mass-produce penicillin, launching Pfi zer into the modern pharmaceutical era. Pfi zer Canada now has a Specialty Division which is committed to advancing the scientifi c understanding of diseases in the areas of oncology, HIV, infectious diseases, endocrinology and ophthalmology. Research in oncology now represents the Pfi zer’s largest research and development investment.
Pfi zer Canada is a leader in Canadian healthcare research, investing more than $137 mil- lion in research and development activities, contributions and partnerships in 2007. The company has invested more than $1 billion in R&D since 2000. As one of the top corporate charitable donors in Canada, Pfi zer Canada is a proud member of Imagine Canada and its Caring Company program. In 2007, Pfi zer Canada’s Community Investment Program sup- ported more than 1,400 non-profi t organizations and projects across the country with a total investment of over $25 million.
For more information, visit www.pfi zer.ca.
Cytokines Montreal 2008 63 64 Cytokines Montreal 2008