DOCSLIB.ORG

Cytokines MONTRÉAL 2008

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Cytokines MONTRÉAL 2008 Cytokines MONTRÉAL 2008 Translating Science into Health: Cytokines in Cancer, Infl ammation and Infectious Diseases 7th Joint Conference of the International Cytokine Society and the International Society for Interferon and Cytokine Research Photo: Tourisme Montréal Photo: Tourisme October 12-16, 2008 Fairmont Queen Elizabeth Hotel Montreal Quebec CANADA Cytokines Montreal 2008 1 PROGRAM From cell separation to molecular analysis The Gold Standard in Cell Isolation • Separation of functional, cytokine-secreting cells • Virtually any cell type from any species • Superior viability, purity and recovery Cytokines and Growth Factors • New, broad portfolio: human - mouse - rat • Excellent purity and activity • Optimized for cell culture applications MACSmolecular Tools for Molecular Analysis • Tools for signal transduction • State of the art microRNA analysis • Comprehensive gene expression profiling Unless otherwise specifically indicated, Miltenyi Biotec products and services are for research use only and not for therapeutic or diagnostic use. Miltenyi Biotec Inc. Phone 800 FOR MACS www.miltenyibiotec.com 12740 Earhart Avenue +1 530 888 8871 [email protected] Auburn CA 95602, USA Fax +1 530 888 8925 2 Cytokines Montreal 2008 ContentsWelcome to Montreal ..................................................................................... 4-5 Sponsors and Exhibitors ................................................................................... 6 Conference Venue ............................................................................................ 11 Scientifi c Information ...................................................................................... 12 Registration ...................................................................................................... 14 Program at a Glance ........................................................................................ 15 Conference Floor Plan ..................................................................................... 16 Invited Speakers .............................................................................................. 16 Scientifi c Program Sunday, October 12 ............................................................................... 17 Monday, October 13 .............................................................................. 18 Tuesday, October 14 .............................................................................. 28 Wednesday, October 15 ........................................................................ 36 Thursday, October 16 ............................................................................ 45 General Information ........................................................................................ 47 Social Program ................................................................................................ 48 A Walking Tour of Downtown ......................................................................... 50 Canadian Organizing Committee John Hiscott, McGill University Karen Mossman, McMaster University Marc Servant, Université de Montréal Michele Barry, University of Alberta Eleanor Fish, University of Toronto John Schrader, University of British Columbia International Organizing Committee Christine Czarniecki (USA) Alberto Mantovani (Italy) Thomas Decker (Austria) Eliane Meurs (France) Scott K. Durum (USA) Luke A.J. O’Neill (Ireland) Takashi Fujita (Japan) Nancy Reich (USA) Adolfo Garcia-Sastre (USA) Christian Schindler (USA) Otto Haller (Germany) Josef Schwarzmeier (Italy) Raymond Kaempfer (Israel) Michael Tovey (France) George Kukolj (Canada) Carl Ware (USA) Santo Landolfo (Italy) Bryan Williams (Australia) Allan Lau (China) Howard Young (USA) Warren Leonard (USA) Cytokines Montreal 2008 3 Bienvenue’est avec grand plaisir à que jeMontréal vous souhaite la bienvenue à cette 7e rencontre conjointe de la Société internationale pour la recherche sur Cl’interféron et les cytokines et de la Société internationale des cytokines : Cytokines 2008. Notre conférence a mobilisé l’expertise biomédicale et les efforts de ces deux sociétés afi n de vous présenter une mise à jour complète des hypothèses les plus récentes quant au rôle élémentaire et clinique des cytokines dans le cancer, l’infl ammation et les maladies infectieuses. Le thème général de cette conférence, l’utilisation des connaissances scientifi ques pour améliorer la santé, a été choisi afi n de mettre l’emphase sur l’intégration des recherches fondamentales, précliniques, pharmaceutiques et cliniques dans les domaines du cancer, de la modulation immunitaire, de l’infl ammation et des maladies infectieuses. Les sujets abordés comprendront l’identifi cation des pathogènes et leur signalisation pour le déclenchement d’une réaction immunitaire, l’infl ammation et le cancer, la biologie et les fonctions des cellules immunitaires et des cytokines, et les stratégies utilisées par les pathogènes pour échapper à la réaction immunitaire de l’hôte. Une part importante de la conférence sera aussi dédiée aux traitements agissant sur les cytokines dans le cancer et d’autres troubles de santé, ainsi que sur les thérapies émergentes ayant pour cible les cytokines dans les maladies autoimmunes et infl ammatoires. Des scientifi ques chevronnés, des jeunes chercheurs, des médecins, des boursiers postdoctoraux, des étudiants aux cycles supérieurs et des représentants des compagnies pharmaceutiques profi teront amplement de ce lieu de réunion favorisant les échanges. Nous croyons que cette conférence—qui a lieu dans la belle ville cosmopolite de Montréal lors de l’époustoufl ante fête des couleurs de l’automne—mettra en évidence les meilleures recherches actuelles sur les cytokines. 4 Cytokines Montreal 2008 Welcomet is my pleasure to welcome to youMontreal to the 7th Joint Meeting of the International Society for Interferon and Cytokine Research and the IInternational Cytokine Society: Cytokines 2008. Our Conference has harnessed the biomedical expertise and energies of both societies to provide a comprehensive update of recent insights into basic and clinical aspects of Cytokines in Cancer, Infl ammation and Infectious Diseases. The overall theme of this Conference is Translating Science into Health, and is chosen to emphasize the integration of basic, pre-clinical, pharmaceutical and clinical research in the areas of cancer, immune modulation, infl ammation and infectious diseases. Topics to be covered include: pathogen recognition and signaling to the immune response, infl ammation and cancer, the biology and functions of immune cells and cytokines, and pathogen strategies to evade the host immune response. Part of the conference is also devoted to cytokine-based therapies in malignancy and other disorders, as well as emerging therapies targeting cytokines in autoimmune and infl ammatory diseases. Senior scientists, young investigators, physicians, postdoctoral fellows, graduate students and representatives of the pharmaceutical industry will all benefi t from the interactions available at this venue. We believe that this Conference— set in the beautiful cosmopolitan city of Montreal during the stunning fall display of colors—will refl ect the best of current cytokine research. Cytokines Montreal 2008 5 THANK YOU TO Platinum Gold Silver Bronze 6 Cytokines Montreal 2008 OUR SPONSORS Sponsors Supporter Other Amounts Cytokines Montreal 2008 7 Exhibitors Assay Designs, Inc. BioLegend, Inc. Emily Riesterer Claudia Arellano, Marketing Coordinator Marketing Communications Supervisor 11080 Roselle Street 5777 Hines Dr. San Diego, CA 92121 Ann Arbor, MI 48108 Tel: 858-455-9588 Tel: 800-833-8651 or 734-668-6113 Fax: 858-455-9587 Fax: 734-668-2793 Website: http://www.biolegend.com/ Website: www.assaydesigns.com BOOTH #3 BOOTH #1 Representatives: Gene (Jeng Guang) Lay, Benjamin (Brad) Kraft, Representative: Tonya Goodman Shaoquan Ji Assay Designs manufactures immunassays, antibodies, and BioLegend, Inc. manufactures reagents for immunology and proteins for the academic and pharmaceutical research markets, cell biology research. Selection of fl uorochrome conjugated including custom immunoassay development and custom bulk antibodies, including Pacifi c Blue, Alexa and tandem dyes. reagent production and conjugation. Novel antibodies: Treg (FOXP3, TSLP-R, GITR). Innate Immunity (TLRs, NTB-A, CCR7), Cytokines.Chemokines (IL-17, 1L-23,TSLP), BD Biosciences Stem Cells (Nanog, FZD9, SOX-2, REX-1, FOXD3, FOXO3a); for FACS, ELISA, ELISPOT, IHC, IP, IF and WB. Andrea Brueschke, Product Manager 2280 Argentia Road Mississauga, ON L5N 6H8 Cedarlane Laboratories Ltd. Tel: 905-542-6285 Naomi Wessel-Bonnar, Marketing Coordinator Fax: 905-542-9391 4410 Paletta Court Website: http://www.bdbiosciences.com/ Burlington, ON L7L 5R2 Tel: 289-288-0001, Toll Free: 1-800-268-5058 BOOTH #12 Fax: 289-288-0020, Toll Free: 1-800-638-5099 Representatives: Alex Brunet, Benoit Lachapelle Website: http://www.cedarlanelabs.com/ BD Biosciences (Becton, Dickinson and Company) is a medical BOOTH #9 & 10 technology company that serves healthcare institutions, clinical Representatives: Kyle Pahapill and Kevin Tutenberg laboratories, life science researchers, and industry. BD manu- factures and sells a broad range of medical supplies, devices, Cederlane specializes in providing high quality reagents to laboratory equipment and diagnostic products. BD Biosciences, the life science community. We are an ISO 9001: 2000 and ISO a segment of BD, provides a comprehensive portfolio of con- 13485:2003 registered
Load more

Recommended publications
  • The Role of Polyadenylation in the Induction of Inflammatory Genes
    The role of polyadenylation in the induction of inflammatory genes Raj Gandhi BSc & ARCS Thesis submitted for the degree of Doctor of Philosophy September 2016 Declaration Except where acknowledged in the text, I declare that this thesis is my own work and is based on research that was undertaken by me in the School of Pharmacy, Faculty of Science, The University of Nottingham. i Acknowledgements First and foremost, I give thanks to my primary supervisor Dr. Cornelia de Moor. She supported me at every step, always made time for me whenever I needed it, and was sympathetic during times of difficulty. I feel very, very fortunate to have been her student. I would also like to thank Dr. Catherine Jopling for her advice and Dr. Graeme Thorn for being so patient and giving me so much help in understanding the bioinformatics parts of my project. I am grateful to Dr. Anna Piccinini and Dr. Sadaf Ashraf for filling in huge gaps in my knowledge about inflammation and osteoarthritis, and to Dr. Sunir Malla for help with the TAIL-seq work. I thank Dr. Richa Singhania and Kathryn Williams for proofreading. Dr. Hannah Parker was my “big sister” in the lab from my first day, and I am very grateful for all her help and for her friendship. My project was made all the more enjoyable/bearable by the members of the Gene Regulation and RNA Biology group, especially Jialiang Lin, Kathryn Williams, Dr. Richa Singhania, Aimée Parsons, Dan Smalley, and Hibah Al-Masmoum. Barbara Rampersad was a wonderful technician. Mike Thomas, James Williamson, Will Hawley, Tom Upton, and Jamie Ware were some of the best of friends I could have hoped to make in Nottingham.
    [Show full text]
  • Beyond Vaccines: Promising Therapeutics for COVID-19 and Emerging Viruses
    Research Canada speaks to Dr. Eleanor Fish, a scientific advisor to Canada’s COVID- 19 Therapeutics Task Force Beyond Vaccines: Promising Therapeutics for COVID-19 and Emerging Viruses The federal government’s COVID-19 Therapeutics Task Force provides advice on the best and most promising treatments for COVID-19 procurement, whether these are still in development and merit support, including via applications to the federal Strategic Innovation Fund, or are existing medications. The Task Force also makes recommendations on therapies developed for a different use that may have an application to COVID-19. Dr. Eleanor Fish is among 11 science advisors to the Therapeutics Task Force. A Professor of Immunology at the University of Toronto and a Senior Scientist at University Health Network, she investigates the behaviour of cytokines, which play a role in cell-to-cell communication during the body’s immune response. In a recent Research Canada interview with Ms. Deborah Gordon-El- Bihbety, President and CEO, Dr. Fish talked about the critical place of therapeutics in the battle against COVID-19, and their important role in preparing for the diseases and epidemics to come. "Vaccines are a very important tool in our toolbox against COVID-19, but they are not a complete solution." - Dr. Eleanor Fish 1 RESEARCH CANADA: Canada’s vaccination campaign is under way, and we’ve been told that all Canadians who want a vaccine will have it by next fall. What role do therapeutics play, separate from vaccines, in the fight against COVID-19? DR. ELEANOR FISH: Vaccines are a very important tool in our toolbox against COVID-19, but they are not a complete solution.
    [Show full text]
  • ISICR Vol. 15.1
    ISICR Officers President Eleanor Fish President-elect INTERNATIONAL SOCIETY FOR Leonidas Platanias INTERFERON AND CYTOKINE RESEARCH Secretary April 2008 Tom Hamilton Volume 15, No. 1 Treasurer Bob Friedman Executive Director A Message from the new ISICR Cliff Brownstein President, Eleanor Fish It is with gratitude and humility that I assume the Future ISICR Meetings responsibilities of incoming President of the ISICR. I am honored to have been elected by my peers and am fortunate to have in place a Board of 2008 Meeting Directors and Committee members that are as Joint ISICR/ICS committed to strengthening our Society as I am. In Montreal, Canada recent months, to ensure that our Society reflects Oct. 12-16 the scientific activities of junior investigators, as positions have www.cytokines2008.org become vacant on the various ISICR Committees, in consultation 2009 Meeting with the Committee Chairs I have made best efforts to invite the par- Joint ISICR/ICS/SLB ticipation of younger investigators who share our vision of a strong, Lisbon, Portugal international, collegial Society. I invite members to participate in your Society - just contact me to let me know of your interest. 2010 Meeting Joint ISICR/ICS Within recent years we have seen a revival of interest in the Chicago, Illinois pleiotropic activities of interferons, touching on many different bio- logical disciplines. Moreover, the role of cytokines and how they ISICR WWW Site inform us of biological processes in normal and diseased states is an www.ISICR.org ever expanding field. I would like to focus my tenure as President on a number of key areas: ISICR Business Office O Communication.
    [Show full text]
  • Dec 08 News Vol 15 No 3 Final.Qxp
    ISICR Officers President Eleanor Fish President-elect Leonidas Platanias Secretary Tom Hamilton December 2008 - Volume 15, No. 3 Treasurer Bob Friedman Executive Director One on one: An Interview with Cliff Brownstein Giorgio Trinchieri, Recipient of the 2008 Milstein Award Future ISICR Meetings Thomas Tan 2009 Meeting Giorgio Trinchieri received his medical degree Joint ISICR/ICS/SLB from the University of Torino, Italy, in 1973. He Lisbon, Portugal was a member of the Basel Institute for Immunology (Basel, Switzerland) and an investi- 2010 Meeting gator at the Swiss Institute for Experimental Joint ISICR/ICS Cancer Research (Epalanges sur Lausanne, Chicago, Illinois Switzerland). From 1979 to 1999 he was at Wistar Institute in Philadelphia and became Hilary Koprowski Professor and Chairman of the Immunology Program; he ISICR WWW Site was also Wistar Professor of Medicine at the University of www.ISICR.org Pennsylvania. He then served as director of the Schering Plough Laboratory for Immunological Research in Dardilly, France, and an ISICR Business Office NIH Fogarty Scholar at the Laboratory for Parasitic Diseases, [email protected] NIAID, before becoming director of the Cancer and Inflammation TEL: 301-634-7250 Program (CIP) and Chief of the Laboratory of Experimental FAX: 301-634-7420 Immunology at NCI in August 2006. As CIP director, he oversees the operations of two major NCI intramural laboratories, the Laboratory ISICR Newsletter Editors of Experimental Immunology and the Laboratory of Molecular Howard Young Immunoregulation. These two laboratories constitute the major [email protected] immunologic component of the inflammation and cancer initiative, Fax: 301-846-1673 which spans the NCI's campuses in Frederick and Bethesda and seeks Hannah Nguyen to partner NCI's expertise in inflammation and immunology with its cutting-edge cancer etiology and carcinogenesis program.
    [Show full text]
  • 2008-05-13-Professors Marc Feldmann and Sir Ravinder Maini
    Contact: Seema Kumar Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (908) 218-6460 or [email protected] Frederik Wittock Johnson & Johnson Pharmaceutical Research & Development (Belgium) +32 14 60 57 24 or [email protected] Professors Marc Feldmann and Sir Ravinder Maini Named Winners of the 2008 Dr. Paul Janssen Award for Biomedical Research New York, N.Y. – May 13, 2008 – Johnson & Johnson today announced that Professor Marc Feldmann, FMedSci, FAA, FRS and Emeritus Professor Sir Ravinder N. Maini, FRCP, FMedSci, FRS of the Kennedy Institute of Rheumatology, Imperial College London have been named the recipients of the 2008 Dr. Paul Janssen Award for Biomedical Research by an independent selection committee of world-renowned scientists. The award salutes the most passionate and creative scientists in basic or clinical research, whose scientific achievements have made, or have strong potential to make, a measurable impact on human health. Feldmann and Maini were selected for their role in the discovery of tumor necrosis factor-alpha, or TNF-alpha, as an effective therapeutic target for rheumatoid arthritis and other chronic inflammatory conditions afflicting millions worldwide. The award, which includes a $100,000 prize, will be presented to the winners at events in New York and Beerse, Belgium in September. According to Solomon Snyder, Ph.D., Distinguished Service Professor of Neuroscience, Pharmacology and Psychiatry, Johns Hopkins School of Medicine and Chairman, Janssen Award Selection Committee, “The work of Feldmann and Maini exemplifies the bench-to-bedside approach that Paul Janssen’s contributions epitomized. It is extremely rare for researchers to identify a molecular messenger in test tube studies, demonstrate its physiologic relevance in animals and themselves carry these efforts forward to a successful clinical demonstration.
    [Show full text]
  • The Recent History of Tumour Necrosis Factor (Tnf)
    THE RECENT HISTORY OF TUMOUR NECROSIS FACTOR (TNF) The transcript of a Witness Seminar held by the History of Modern Biomedicine Research Group, Queen Mary University of London, on 14 July 2015 Edited by A Zarros, E M Jones, and E M Tansey Volume 60 2016 ©The Trustee of the Wellcome Trust, London, 2016 First published by Queen Mary University of London, 2016 The History of Modern Biomedicine Research Group is funded by the Wellcome Trust, which is a registered charity, no. 210183. ISBN 978 1 91019 5208 All volumes are freely available online at www.histmodbiomed.org Please cite as: Zarros A, Jones E M, Tansey E M. (eds) (2016) The Recent History of Tumour Necrosis Factor (TNF). Wellcome Witnesses to Contemporary Medicine, vol. 60. London: Queen Mary University of London. CONTENTS What is a Witness Seminar? v Acknowledgements E M Tansey and A Zarros vii Illustrations and credits ix Abbreviations xi Introduction Professor Jon Cohen xv Transcript Edited by A Zarros, E M Jones, and E M Tansey 1 Appendix 1 Timeline of important events in the history of TNF 73 Appendix 2 Simplified overview of the main biological actions of TNF in rheumatoid arthritis 75 Appendix 3 Overview of TNF inhibitors mentioned in the current Witness Seminar transcript 77 Glossary 79 Biographical notes 83 References 93 Index 105 Witness Seminars: Meetings and publications 111 WHAT IS A WITNESS SEMINAR? The Witness Seminar is a specialized form of oral history, where several individuals associated with a particular set of circumstances or events are invited to meet together to discuss, debate, and agree or disagree about their memories.
    [Show full text]
  • Pnas11052ackreviewers 5098..5136
    Acknowledgment of Reviewers, 2013 The PNAS editors would like to thank all the individuals who dedicated their considerable time and expertise to the journal by serving as reviewers in 2013. Their generous contribution is deeply appreciated. A Harald Ade Takaaki Akaike Heather Allen Ariel Amir Scott Aaronson Karen Adelman Katerina Akassoglou Icarus Allen Ido Amit Stuart Aaronson Zach Adelman Arne Akbar John Allen Angelika Amon Adam Abate Pia Adelroth Erol Akcay Karen Allen Hubert Amrein Abul Abbas David Adelson Mark Akeson Lisa Allen Serge Amselem Tarek Abbas Alan Aderem Anna Akhmanova Nicola Allen Derk Amsen Jonathan Abbatt Neil Adger Shizuo Akira Paul Allen Esther Amstad Shahal Abbo Noam Adir Ramesh Akkina Philip Allen I. Jonathan Amster Patrick Abbot Jess Adkins Klaus Aktories Toby Allen Ronald Amundson Albert Abbott Elizabeth Adkins-Regan Muhammad Alam James Allison Katrin Amunts Geoff Abbott Roee Admon Eric Alani Mead Allison Myron Amusia Larry Abbott Walter Adriani Pietro Alano Isabel Allona Gynheung An Nicholas Abbott Ruedi Aebersold Cedric Alaux Robin Allshire Zhiqiang An Rasha Abdel Rahman Ueli Aebi Maher Alayyoubi Abigail Allwood Ranjit Anand Zalfa Abdel-Malek Martin Aeschlimann Richard Alba Julian Allwood Beau Ances Minori Abe Ruslan Afasizhev Salim Al-Babili Eric Alm David Andelman Kathryn Abel Markus Affolter Salvatore Albani Benjamin Alman John Anderies Asa Abeliovich Dritan Agalliu Silas Alben Steven Almo Gregor Anderluh John Aber David Agard Mark Alber Douglas Almond Bogi Andersen Geoff Abers Aneel Aggarwal Reka Albert Genevieve Almouzni George Andersen Rohan Abeyaratne Anurag Agrawal R. Craig Albertson Noga Alon Gregers Andersen Susan Abmayr Arun Agrawal Roy Alcalay Uri Alon Ken Andersen Ehab Abouheif Paul Agris Antonio Alcami Claudio Alonso Olaf Andersen Soman Abraham H.
    [Show full text]
  • 2020 Annual Report
    2020 Annual Report Make this cover come alive with augmented reality. Details on inside back cover. Contents The Walter and Eliza Hall Institute About WEHI 1 of Medical Research President’s report 2 Parkville campus 1G Royal Parade Director’s report 3 Parkville Victoria 3052 Australia Telephone: +61 3 9345 2555 WEHI’s new brand launched 4 Bundoora campus 4 Research Avenue Our supporters 10 La Trobe R&D Park Bundoora Victoria 3086 Australia Exceptional science and people 13 Telephone: +61 3 9345 2200 www.wehi.edu.au 2020 graduates 38 WEHIresearch Patents granted in 2020 40 WEHI_research WEHI_research WEHImovies A remarkable place 41 Walter and Eliza Hall Institute Operational overview 42 ABN 12 004 251 423 © The Walter and Eliza Hall Institute Expanding connections with our alumni 45 of Medical Research 2021 Diversity and inclusion 46 Produced by the WEHI’s Communications and Marketing department Working towards reconciliation 48 Director Organisation and governance 49 Douglas J Hilton AO BSc Mon BSc(Hons) PhD Melb FAA FTSE FAHMS WEHI Board 50 Deputy Director, Scientific Strategy WEHI organisation 52 Alan Cowman AC BSc(Hons) Griffith PhD Melb FAA FRS FASM FASP Members of WEHI 54 Chief Operating Officer WEHI supporters 56 Carolyn MacDonald BArts (Journalism) RMIT 2020 Board Subcommittees 58 Chief Financial Officer 2020 Financial Statements 59 Joel Chibert BCom Melb GradDipCA FAICD Financial statements contents 60 Company Secretary Mark Licciardo Statistical summary 94 BBus(Acc) GradDip CSP FGIA FCIS FAICD The year at a glance 98 Honorary
    [Show full text]
  • CMAJ WHO Enters New Terrain in Ebola Research
    CMAJ News WHO enters new terrain in Ebola research he meeting on unproven inter- ventions for Ebola at the World T Health Organization on Sept. 4 and 5 takes the global agency into “absolutely uncharted territory,” says WHO spokesperson, Dr. Margaret Harris. “We’re actually often criticized for being incredibly slow about saying, ‘Do this over that’, because we demand enormous levels of evidence,” she says. But for Ebola virus disease, there are no approved therapies, so WHO is attempting to move investigational interventions forward, including medi- cations, vaccines and so-called conva- lescent serum, made from the blood of survivors. The Sept. 4 meeting, aimed at guid- ing research in the midst of the out- NikiLitov/iStock/Thinkstock break, marks a sharp turn for WHO, In the absence of approved therapies for patients diagnosed with Ebola, WHO is taking where research efforts are viewed as the unprecedented step of attempting to move research forward. fragmented. About five years ago, WHO eliminated its office of research break at 78%, and in late August the three control animals died. Five of the strategy; the department leading the disease spread to another country — seven people treated with ZMapp have Ebola research effort, known as Senegal — and another city — Port survived, but it is unclear if the medica- Knowledge, Ethics and Research, was Harcourt, Nigeria, the hub of Nigeria’s tion helped them to recover and it will only formed at the end of 2013. But the oil and gas industry, where Canadian be months before there is more ZMapp Ebola crisis forced a change.
    [Show full text]
  • Keynote Speakers
    Keynote Speakers Dr. Katie Flanagan, BA(Hons) MBBS DTM&H MA PhD CCST FRCP FRACP, leads the Infectious Diseases Service at Launceston General Hospital in Tasmania, and is a clinical Associate Professor at the University of Tasmania, Australia. She obtained a degree in Physiological Sciences from Oxford University, followed by her MBBS from the University of London. She is a UK and Australia accredited Infectious Diseases Physician. Katie obtained her PhD in malaria immunology based at Oxford University. She was previously Head of Infant Immunology Research at the MRC Laboratories in The Gambia from 2005-11. Dr. Thumbi Ndung’u, BVM, PhD, is the Scientific Director of the HIV Pathogenesis Programme at the University of KwaZulu Natal in South Africa. He is a virologist with a PhD from Harvard University, Boston, USA. His main research interests are in host-virus interactions and immune responses in HIV-1 infection. He is also interested in the development of biomedical interventions that can be used in resource-limited settings to prevent or treat HIV/AIDS. He is an Associate Professor in HIV/AIDS Research at the the Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu-Natal. He holds the South African Department of Science and Technology/National Research Foundation (DST/NRF) Research Chair in Systems Biology of HIV/AIDS. Dr. Josef Penninger BA, MD, PhD, is Scientific Director of the Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria. He is Professor in the Departments of Immunology and Medical Biophysics at the University of Toronto, Canada, Professor of Genetics, University of Vienna, Austria, Honorary Professor of Peking Union Medical College/Chinese Academy of Medical Sciences, Beijing, China, Affiliate Scientist, Keenan Research Centre, Li Ka Shing Knowledge Institute of St.
    [Show full text]
  • Anti-TNF Therapy from the Bench to the Clinic
    CMJ1002-Scott_CLA.qxd 3/11/10 2:04 PM Page 161 Current key developments Anti-TNF therapy from the bench mediated by TNF-␣ to take place in promoting immune-medi- ated inflammation and tissue destruction. to the clinic: a paradigm of The hypothesis that TNF was a candidate molecular thera- translational research peutic target was further strengthened by the demonstration in vivo of suppression of arthritis and tissue destruction by treating murine collagen-induced arthritis, a model of RA, with a hamster Ravinder N Maini, emeritus professor of rheumatology, The monoclonal and specific antibody directed against TNF-␣.8 Kennedy Institute of Rheumatology Division, Imperial College London Proof of concept clinical trials and back to the Email: [email protected] laboratory for mechanism of action studies In the late 1980s Centocor Inc had developed cA2, a mouse x Introduction human chimaeric anti-TNF-␣ specific neutralising antibody, sub- In the 1980s emerging recombinant DNA and monoclonal anti- sequently known as infliximab (Remicade®) for the treatment of body technology stimulated research into the molecular con- septic shock, and agreed to support a proof concept study in cepts of pathogenesis of disease. A number of cytokines were DMARD-recalcitrant RA. In 1992, 20 patients were treated and being identified and their biological properties, such as their impressive therapeutic efficacy with excellent tolerability was doc- role in activation, proliferation, and cell death of immune, umented.9 Continuing studies established pharmacokinetics and inflammatory and mesenchymal cells by autocrine and the need for repeated therapy.10,11 paracrine action in the tissue micro-environment, made a com- Next in patients with active disease despite prior therapy with pelling case for their involvement in rheumatoid arthritis (RA).
    [Show full text]
  • Trial Please Esteemed Panel of Researchers
    The Biomedical and Life Sciences Collection • Regularly expanded, constantly updated • Already contains over 700 presentations • Growing monthly to over 1,000 talks “This is an outstanding Seminar style presentations collection. Alongside journals and books no self-respecting library in institutions hosting by leading world experts research in biomedicine and the life sciences should be without access to these talks.” When you want them, Professor Roger Kornberg, Nobel Laureate, Stanford University School of Medicine, USA as often as you want them “I commend Henry Stewart Talks for the novel and • For research scientists, graduate • Look and feel of face-to-face extremely useful complement to teaching and research.” students and the most committed seminars that preserve each Professor Sir Aaron Klug OM FRS, Nobel Laureate, The Medical senior undergraduates speaker’s personality and Research Council, University of approach Cambridge, UK • Talks specially commissioned “This collection of talks is a and organized into • A must have resource for all seminar fest; assembled by an extremely eminent group of comprehensive series that cover researchers in the biomedical editors, the world class speakers deliver insightful talks illustrated both the fundamentals and the and life sciences whether in with slides of the highest latest advances academic institutions or standards. Hundreds of hours of thought provoking presentations industry on biomedicine and life sciences. • Simple format – animated slides It is an impressive achievement!” with accompanying narration, Professor Herman Waldmann FRS, • Available online to view University of Oxford, UK synchronized for easy listening alone or with colleagues “Our staff here at GSK/Research Triangle Park wishes to convey its congratulations to your colleagues at Henry Stewart for this first-rate collection of talks from such an To access your free trial please esteemed panel of researchers.
    [Show full text]