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Supplemetary Table S1: 72 Preeclampsia Candidate Genes Investigated and Resulting P-Values for Th Gene Chr Start End Full Gene

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Supplemetary Table S1: 72 Preeclampsia Candidate Genes Investigated and Resulting P-Values for Th Gene Chr Start End Full Gene Supplemetary Table S1: 72 preeclampsia candidate genes investigated and resulting p-values for th Gene Chr Start End Full Gene Name LCT 2 136545415 1365947540 Lactase PER3 1 7784703 7845177 period_circadian_clock_3 NOS3 7 150990995 151014588 nitric_oxide_synthase_3 XPO5 6 43490068 43543812 exportin_5 LY9 1 160765864 160798045 lymphocyte_antigen_9 ERAP1 5 96760810 96808100 endoplasmic_reticulum_aminopeptidase_1 DPP7 9 137110542 137114718 dipeptidyl_peptidase_7 LNPEP 5 96935464 97037515 leucyl/cystinyl_aminopeptidase HS3ST2 16 22814177 22916338 heparan_sulfate_(glucosamine)_3_O_sulfotransferase_2 ERAP2 5 96875939 96919716 endoplasmic_reticulum_aminopeptidase_2 COL4A2 13 110307267 110513027 collagen_type_IV_alpha_2 SLC2A6 9 133471095 133479137 solute_carrier_family_2_(facilitated_glucose_transporter)_member TNFRSF14 1 2556366 2563829 tumor_necrosis_factor_receptor_superfamily_member_14 KDR 4 55078477 55125589 kinase_insert_domain_receptor SLC27A2 11 124933013 124960412 solute_carrier_family_37 COL4A1 13 110148963 110307149 collagen_type_IV_alpha_1 ACP5 19 11685475 11689801 acid_phosphatase_5_tartrate_resistant QRFPR 4 121329314 121381059 Pyroglutamylated_RFamide_Peptide_Receptor STOX2 4 183905356 184023526 storkhead_box_2 EDN1 6 12290363 12297194 endothelin_1 ACVR1C 2 157526767 157629005 activin_A_receptor_type_IC STOX1 10 68827541 68895432 storkhead_box_1 FLT1 13 28300344 28495095 fms_related_tyrosine_kinase_1 AGT 1 230702523 230714297 angiotensinogen MMP2 16 55478971 55506691 matrix_metallopeptidase_2 LMAN1 18 56995056 57026508 lectin_mannose_binding_1 GTF3C4 9 135545728 135565470 general_transcription_factor_IIIC_polypeptide_4 TGFB1 19 41330323 41353911 transforming_growth_factor_beta_1 LRP1B 2 140988996 142889270 Low Density Lipoprotein Receptor-Related Protein 1B ISPD 7 16127152 16460947 isoprenoid_synthase_domain_containing NOS2 17 27756766 27800499 nitric_oxide_synthase_2 PDK4 7 95583499 95596491 pyruvate_dehydrogenase_kinase_isozyme_4 INHA 2 219572195 219575713 inhibin_alpha IL10 1 206767602 206772494 interleukin_10 PTGS2 1 186671791 186680427 prostaglandin_endoperoxide_synthase_2 ACVR1 2 157736449 157875862 activin_A_receptor_type_I ACVR2A 2 147844517 147930824 activin_A_receptor_type_IIA INHBB 2 120346143 120351808 inhibin_beta_B GCA 2 163200583 163219148 Grancalcin FST 5 53480409 53487134 follistatin TNF 6 31575567 31578336 tumor_necrosis_factor VEGFA 6 43770707 43784949 vascular_endothelial_growth_factor_A SHH 7 155799986 155812273 sonic_hedgehog IL6 7 22725884 22732002 interleukin_6 INHBA 7 41685114 41703108 inhibin_beta_A SERPINE1 7 101127089 101139266 serpin_peptidase_inhibitor_clade_E CD72 9 35609533 35619542 CD72_molecule ENG 9 127815017 127854636 endoglin QRFP 9 130892702 130896812 Pyroglutamylated_RFamide_Peptide CYP17A1 10 102830531 102837533 cytochrome_P450_family_17_subfamily_A_polypeptide_1 FAM21A 10 51827684 51893269 family_with_sequence_similarity_21_member_A INS 11 2159779 2161341 Insulin ADIPOR2 12 1800247 1897845 adiponectin_receptor_2 IFNG 12 68154768 68159747 interferon_gamma BMF 15 40380091 40401085 Bcl2_modifying_factor CEP152 15 49030135 49103343 centrosomal_protein_152kDa CDH1 16 68737225 68835548 cadherin_1_type_1_E_cadherin ALDOA 16 30076994 30081741 aldolase_A_fructose_bisphosphate SLC2A4 17 7281667 7288257 solute_carrier_family_2_(facilitated_glucose_transporter)_member ANKFY1 17 4066665 4167142 ankyrin_repeat_and_FYVE_domain_containing_1 CYGB 17 74523430 74533987 cytoglobin SMAD7 18 48919853 48950711 SMAD_family_member_7 DBP 19 48630030 48637438 D_site_of_albumin_promoter_(albumin_D_box)_binding_protein GPI 19 34856032 34893318 glucose_6_phosphate_isomerase P2RY11 19 10222197 10226064 purinergic_receptor_P2Y_G_protein_coupled_11 AVP 20 3082556 3084724 arginine_vasopressin OXT 20 3071620 3072517 oxytocin/neurophysin_I_prepropeptide_ MMP9 20 46008908 46016561 matrix_metallopeptidase_9 TEF 22 41777933 41795332 thyrotrophic_embryonic_factor XIAP X 123859812 123913976 X_linked_inhibitor_of_apoptosis_E3_ubiquitin_protein_ligase RENBP X 153200722 153210232 renin_binding_protein ZDHHC9 X 128937264 128977910 zinc_finger_DHHC_type_containing_9 Table S2: Categorization of variants by sequencing platform and there intersection. Sequencing Platform Variant Function Illumina TruSeq AmpliSeq Intersected 49,622 (22 30,172 (5 Synonymous 47,852 (9 splicing) splicing) splicing) 77,770 (36 62,883 (17 31,007 (9 Nonsynonymous splicing) splicing) splicing) Intronic 1315 114,842 62 22,034 (18 Exonic non-coding RNA 662 (2 splicing) 131 splicing) 3’UTR 102,646 7,012 3,866 5’UTR 27,613 5,346 2,602 Mixed 3’5’ 14 19 0 Downstream 185 446 3 Upstream 226 1148 13 Upstream/Downstream 29 63 0 Stop/Gain 1253 1088 334 Stop/Loss 125 (1 splicing) 68 29 Unclassified Exonic 1796 1473 Intergenic 1186 144 45 Intronic non-coding RNA 4589 3435 155 Splicing 93 673 8 Other 12 2 0 Total 290,607 247,144 69,298 rs1048944 5 34824555RAI14 exonic 0.475 0.4 rs78544176 11 93457532CEP295 exonic 0.047917 0.01 rs9358799 6 24806594FAM65B UTR3 0.433333 0.3 rs1783978 11 57463500ZDHHC5 exonic 0.389584 0.6 rs3744204 17 72999773CDR2L exonic 0.239584 0.2 rs1062600 20 56137798PCK1 exonic 0.395834 0.2 rs111437424 16 1464636UNKL exonic 0.0375 0.9 rs117519030 19 47774680CCDC9 exonic 0.041667 0.00 rs77099580 3 183752964HTR3D;HTR3D exonic;splicing 0.029167 0.01 rs45626541 19 37677748ZNF585B exonic 0.339583 0.2 rs115553646 5 132150132SOWAHA exonic 0.054166 0.1 rs6413437 14 20872863TEP1 exonic 0.054166 0.1 rs34110867 1 232564162SIPA1L2 exonic 0.027083 0.06 rs1128013 22 43195147ARFGAP3 exonic 0.364584 0.3 rs7246479 19 55824332TMEM150B exonic 0.370833 0.5 rs36125344 22 46655779PKDREJ exonic 0.097917 0.06 rs1141684 16 2014591RPS2 exonic 0.04375 0.1 rs144634106 5 139422232NRG2 exonic 0.05625 0.02 rs7114668 11 4842925OR51F2 exonic 0.04375 0.08 rs6971819 7 128315889FAM71F2 exonic 0.1375 0.1 rs2230380 12 26806955ITPR2 exonic 0.270834 0.1 rs200551840 16 74455190CLEC18B UTR5 0.108333. rs4757987 11 5906205OR52E4 exonic 0.34375 0.4 rs10742809 11 5862532OR52E6 exonic 0.26875 0.3 rs55888789 9 139849843LCN12 exonic 0.054166 0.0 rs138379333 1 85559205WDR63 exonic 0.016667 0.003 rs302646 11 87908448RAB38 exonic 0.122916 0.7 rs954144 15 78730591IREB2 UTR5 0.297916 0.3 rs1555048 22 50688348HDAC10 exonic 0.266666 0.8 rs7511651 1 16070871TMEM82 exonic 0.066667 0.1 rs7560668 2 74300717TET3 exonic 0.314584 0.3 rs17373874 4 155411939DCHS2 exonic 0.466666 0. rs56261530 19 4280207SHD exonic 0.104166 0.03 rs4357719 11 5862653OR52E6 exonic 0.329166 0.3 rs4495918 11 5862937OR52E6 exonic 0.329166 0.3 rs10769272 11 5862984OR52E6 exonic 0.329166 0.3 rs4362173 11 5863013OR52E6 exonic 0.329166 0.3 rs10742810 11 5863113OR52E6 exonic 0.329166 0.3 rs1799793 19 45867259ERCC2 exonic 0.297916 0.1 rs78448370 8 142446937MROH5 exonic 0.10625 0.07 rs1135045 16 23489711GGA2 exonic 0.158333 0.6 rs8477 17 79618059PDE6G UTR3 0.2875 0.5 rs141851604 11 5799498OR52N5 exonic 0.008334. rs2278159 18 72178161CNDP2 exonic 0.14375 0.2 rs2075690 19 51519236KLK10 exonic 0.341666 0.5 rs2286873 17 1377943MYO1C exonic 0.285417 0.4 rs554202 11 75428958MOGAT2 exonic 0.3625 0.3 rs220130 21 43531808UMODL1 exonic 0.160416 0.1 rs2961149 7 143807515OR2A2 exonic 0.277083 0 rs28546127 1 22200473HSPG2 exonic 0.072916 0.06 rs2229481 1 22200998HSPG2 exonic 0.072916 0.06 rs2229952 7 81667468CACNA2D1 exonic 0.060416 0.0 rs1056806 1 110233147GSTM1 exonic 0.1375 0.2 rs7893917 10 90585819ANKRD22 exonic 0.322916 0.3 rs35076349 10 7759679ITIH2 exonic 0.05625 0.04 rs118117962 9 140002995MAN1B1 exonic 0.025 0.01 rs267738 1 150940625CERS2 exonic 0.2 0.06 rs2036772 12 102517753PARPBP exonic 0.170833 0. rs33990195 3 113320477SIDT1 exonic 0.077083 0.04 rs2278426 19 11350488C19orf80 exonic 0.041667 0.1 rs1129777 10 91468925KIF20B exonic 0.1625 0.2 rs3758388 10 91488979KIF20B exonic 0.1625 0.2 rs2291439 8 95419698RAD54B exonic 0.297916 0.4 rs41265007 1 156021079UBQLN4 exonic 0.05 0.01 rs4072568 15 80884025ARNT2 exonic 0.108333 0.1 rs15350 18 77211764NFATC1 exonic 0.160416 0.2 rs4682752 3 44775962ZNF501 exonic 0.485416 0.6 rs3736508 11 45975130PHF21A exonic 0.03125 0. rs1051630 5 870619BRD9 exonic 0.070833 0.1 rs41274386 9 96212813FAM120AOS exonic 0.047917 0.02 rs2481598 9 71650752FXN exonic 0.01875 0.9 rs61731692 22 36537725APOL3 exonic 0.102083 0.09 rs2075643 14 51383432PYGL exonic 0.1375 0.2 rs35092547 19 9068990MUC16 exonic 0.03125 0.009 rs35346115 19 9071916MUC16 exonic 0.03125 0.009 rs7216 17 19578873ALDH3A2 exonic 0.345834 0.6 rs7256494 19 54849481LILRA4 exonic 0.252084 0.3 rs12313 10 134017295DPYSL4 exonic 0.170833 0.8 rs704219 12 22354921ST8SIA1 exonic 0.13125 0.8 rs2187016 8 101648164SNX31 exonic 0.172917 0. rs2811741 9 139732331RABL6 exonic 0.16875 0.8 rs2230325 1 52399021RAB3B exonic 0.035416 0.05 rs78451460 16 10769943TEKT5 exonic 0.022916 0.01 rs139376072 1 231335983TRIM67 exonic 0.01875 0.009 rs9898751 17 7950952ALOX15B exonic 0.360416 0.4 rs17689863 2 75882399MRPL19 exonic 0.24375 0.1 rs639905 6 4069685FAM217A exonic 0.222916 0.2 rs1078461 4 185940952HELT exonic 0.08125 0.1 rs78637028 16 3640784SLX4 exonic 0.075 0.04 rs59939128 16 3640785SLX4 exonic 0.075 0.06 rs113490934 16 3650987SLX4 exonic 0.075 0.05 rs79842542 16 3656625SLX4 exonic 0.075 0.05 rs61735644 18 55104016ONECUT2 exonic 0.058334 0.1 rs13447182 22 19467462CDC45 UTR5 0.06875 0.04 rs3822355 5 140186979PCDHA4 exonic 0.422916 0.3 rs2245431 21 30357163LTN1 exonic 0.095834 0. rs5757465 22 39477123APOBEC3G exonic 0.377084 0.2 rs7571 13 25000617PARP4 exonic 0.25625 0.4 rs848547 2 36704144CRIM1 exonic 0.470834 0.6 rs136569 22 45767455SMC1B exonic 0.385416 0. rs34169738 10
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