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Genetic Testing for Cardiovascular Conditions

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Genetic Testing for Cardiovascular Conditions Genetic Testing for Cardiovascular Conditions Cardiology panels available at LifeLabs Genetics include: Condition Selected Cardiology Panels Condition Selected Cardiology Panels • Hereditary Arrhythmia Pulmonary • Pulmonary Disease • Long and Short QT Syndrome Diseases • Pulmonary Hypertension Arrhythmias • Brugada Syndrome • Catecholaminergic Polymorphic • Familial Thoracic Aortic Aneurysm Ventricular Tachycardia Aortopathies and • Ehlers Danlos Syndrome Connective • Marfan Syndrome Tissue Disorders • Arrhythmogenic Right Ventricular • Loeys-Dietz Syndrome Cardiomyopathy Cardiomyopathies • Hypertrophic Cardiomyopathy • Familial hypercholesterolemia Other Cardiology- • Dilated Cardiomyopathy • Congenital Heart Defects related Panels • Noonan and related RASopathies • Hereditary Hemorrhagic Telangiectasia (1) Additional cardiology or cardiology-associated single genes and panels may be available; (2) Please visit www.LifeLabsGenetics.com for updated gene content of each panel; (3) Mitochondrial DNA testing is available as an add-on to any panel ($950 CAD); (4) Many of the above panels can be combined to create a single custom and comprehensive Fixed Panel. All panels can be performed by one of three methodologies Fixed Panels Expanded Panel Progressive Panels ✓ Panels with more focused gene ✓ Largest panel available, covering ✓ WGS-based, meaning inclusion of content means less likelihood of a >6,700 genes non-exonic regions VUS ✓ No need to choose a panel, as all ✓ Best way to call CNVs and other All✓ Curated panels content can means be ordered less work according>6,700 genesto the are alwayspreferred sequenced methodologystructural variants needed to be done by the ordering ✓ 1 step process, meaning no need to ✓ Includes mitochondrial analyses, HCP reflex to larger data when applicable ✓ All sequencing includes repeat ✓ Raw data available ✓ Reflex to WGS available expansion, when applicable Prices start at: Prices start at: Prices start at: $1,450 CAD (Sequencing) $1,350 CAD (Sequencing) $3,850 CAD (Seq+CNV) $1,950 CAD (Seq+CNV) $1,900 CAD (Seq+CNV) +$1,000 (Reflex to WGS) Turn-around time Single Gene: 4 weeks Panels: 4-6 weeks (TAT) Familial Mutation: 2-4 weeks Price: $300 for point mutations, $450 for Dosage (MLPA or qPCR) Visit www.lifelabsgenetics.com to learn more about custom diagnostic panels, whole exome and whole genome sequencing. Contact us [email protected] | 1-84-GENEHELP (1-844-363-4357) Genetic Testing for Cardiovascular Conditions Cardiology gene list per condition: Condition Genes AKAP9, ANK2, CACNA1C, CACNB2, CASQ2, CAV3, DSC2, DSG2, DSP, GPD1L, HCN4, JUP, KCNA5, KCND3, KCNE1, KCNE2, Hereditary Arrhythmia KCNE3, KCNH2, KCNJ2, KCNQ1, NPPA, PKP2, PLN, RYR2, SCN1B, SCN3B, SCN4B, SCN5A, SLMAP, SNTA1, TGFB3, TMEM43 Long and Short QT AKAP9, ANK2, CACNA1C, CALM1, CALM2, CALM3, CAV3, KCNE1, KCNE2, KCNH2, KCNJ2, KCNJ5, KCNQ1, SCN4B, SCN5A, Syndromes SNTA1, TRDN Brugada Syndrome CACNA1C, CACNB2, GPD1L, HCN4, KCNE3, SCN1B, SCN3B, SCN5A, SLMAP Catecholaminergic polymorphic ventricular RYR2, CASQ2, KCNJ2 tachycardia Arrhythmogenic Right Ventricular CDH2, CTNNA3, DES, DSC2, DSG2, DSP, JUP, LMNA, PKP2, PLN, RYR2, SCN5A, TGFB3, TMEM43, TTN Cardiomyopathy ACTC1, ACTN2, ANKRD1, CALR3, CAV3, CRYAB, CSRP3, DES, FHL2, FLNC, GLA, JPH2, LAMP2, LDB3, MYBPC3, MYH6, MYH7, Hypertrophic MYL2, MYL3, MYLK2, MYPN, NEXN, PDLIM3, PLN, PRKAG2, SLC25A4, SOS1, TCAP, TNNC1, TNNI3, TNNT2, TPM1, TRIM63, Cardiomyopathy TTN, TTR, VCL ABCC9, ACTC1, ACTN2, ANKRD1, BAG3, CRYAB, CSRP3, DES, DMD, DNAJC19, DOLK, DSC2, DSG2, DSP, EMD, EYA4, FKTN, Dilated Cardiomyopathy GATA4, GATAD1, ILK, LAMA4, LAMP2, LDB3, LMNA, MURC, MYBPC3, MYH6, MYH7, MYPN, NEBL, NEXN, PDLIM3, PKP2, PLN, PRDM16, RAF1, RBM20, SCN5A, SGCD, TAZ, TBX20, TCAP, TNNC1, TNNI3, TNNT2, TPM1, TTN, TTR, TXNRD2, VCL Noonan and related BRAF, CBL, HRAS, KAT6B, KRAS, LZTR1, MAP2K1, MAP2K2, NF1, NRAS, PTPN11, RAF1, RASA2, RIT1, SHOC2, SOS1, SOS2, RASopathies SPRED1 ABCA3, ACVRL1, AP3B1, ASCL1, BDNF, BLOC1S3, BLOC1S6, BMPR2, CCDC39, CCDC40, CFTR, CSF2RA, CSF2RB, DKC1, DNAAF1, DNAAF2, DNAH11, DNAH5, DNAI1, DNAI2, DNAL1, DOCK8, DTNBP1, EDN3, EFEMP2, ELMOD2, ELN, ENG, FBLN5, Pulmonary Disease FBN1, FLCN, FOXF1, GDNF, HPS1, HPS3, HPS4, HPS5, HPS6, LTBP4, NKX2-1, NME8, NOP10, PARN, PHOX2B, RET, RSPH1, RSPH4A, RSPH9, RTEL1, SCNN1A, SCNN1B, SCNN1G, SERPINA1, SFTPA1, SFTPA2, SFTPB, SFTPC, SFTPD, SMAD9, STAT3, TERC, TERT, TINF2, TSC1, TSC2 Pulmonary Hypertension ACVRL1, BMPR1B, BMPR2, CAV1, EIF2AK4, ENG, FOXF1, GDF2, KCNA5, KCNK3, SMAD9 Familial Thoracic Aortic ACTA2, BGN, CBS, LOX, MAT2A, MFAP5, MYH11, MYLK Aneurysm Ehlers Danlos Syndrome ADAMTS2, ATP7A, B3GALT6, B3GAT3, B4GALT7, CHST14, COL12A1, COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, DSE, and related disorders EFEMP2, ELN, FBLN5, FBN1, FKBP14, FLNA, GORAB, LTBP4, PLOD1, PRDM5, PYCR1, RIN2, SLC39A13, TNXB, ZNF469 Marfan, Loeys-Dietz, and COL3A1, COL5A1, COL5A2, EFEMP2, FBN1, FBN2, NOTCH1, SKI, SLC2A10, SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1, TGFBR2 related disorders Familial APOB, GHR, LDLR, PCSK9 hypercholesterolemia Congenital Heart CFC1, CITED2, CRELD1, FOXH1, GATA4, GATA6, GDF1, NKX2-5, NOTCH1, TBX1, TBX20, ZFPM2 Defects Hereditary Hemorrhagic ACVRL1, ENG, GDF2, SMAD4 Telangiectasia The gene content of our panels is continuously changing. Please visit www.lifelabsgenetics.com for the most up-to-date information. Visit www.lifelabsgenetics.com to learn more about custom diagnostic panels, whole exome and whole genome sequencing. Contact us [email protected] | 1-84-GENEHELP (1-844-363-4357).
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