Genetic Testing for Cardiovascular Conditions

Cardiology panels available at LifeLabs Genetics include:

Condition Selected Cardiology Panels Condition Selected Cardiology Panels • Hereditary Arrhythmia Pulmonary • Pulmonary Disease • Long and Short QT Syndrome Diseases • Pulmonary Hypertension Arrhythmias • • Catecholaminergic Polymorphic • Familial Thoracic Aortic Aneurysm Ventricular Tachycardia Aortopathies and • Ehlers Danlos Syndrome Connective • Marfan Syndrome Tissue Disorders • Arrhythmogenic Right Ventricular • Loeys-Dietz Syndrome Cardiomyopathy Cardiomyopathies • Hypertrophic Cardiomyopathy • Familial hypercholesterolemia Other Cardiology- • Dilated Cardiomyopathy • Congenital Defects related Panels • Noonan and related RASopathies • Hereditary Hemorrhagic Telangiectasia

(1) Additional cardiology or cardiology-associated single and panels may be available; (2) Please visit www.LifeLabsGenetics.com for updated content of each panel; (3) Mitochondrial DNA testing is available as an add-on to any panel ($950 CAD); (4) Many of the above panels can be combined to create a single custom and comprehensive Fixed Panel.

All panels can be performed by one of three methodologies

Fixed Panels Expanded Panel Progressive Panels

✓ Panels with more focused gene ✓ Largest panel available, covering ✓ WGS-based, meaning inclusion of content means less likelihood of a >6,700 genes non-exonic regions VUS ✓ No need to choose a panel, as all ✓ Best way to call CNVs and other All✓ Curated panels content can means be ordered less work according>6,700 genesto the are alwayspreferred sequenced methodologystructural variants needed to be done by the ordering ✓ 1 step process, meaning no need to ✓ Includes mitochondrial analyses, HCP reflex to larger data when applicable ✓ All sequencing includes repeat ✓ Raw data available ✓ Reflex to WGS available expansion, when applicable Prices start at: Prices start at: Prices start at: $1,450 CAD (Sequencing) $1,350 CAD (Sequencing) $3,850 CAD (Seq+CNV) $1,950 CAD (Seq+CNV) $1,900 CAD (Seq+CNV) +$1,000 (Reflex to WGS)

Turn-around time Single Gene: 4 weeks Panels: 4-6 weeks (TAT) Familial Mutation: 2-4 weeks Price: $300 for point mutations, $450 for Dosage (MLPA or qPCR)

Visit www.lifelabsgenetics.com to learn more about custom diagnostic panels, whole exome and whole genome sequencing. Contact us [email protected] | 1-84-GENEHELP (1-844-363-4357) Genetic Testing for Cardiovascular Conditions

Cardiology gene list per condition:

Condition Genes

AKAP9, ANK2, CACNA1C, CACNB2, CASQ2, CAV3, DSC2, DSG2, DSP, GPD1L, HCN4, JUP, KCNA5, KCND3, KCNE1, KCNE2, Hereditary Arrhythmia KCNE3, KCNH2, KCNJ2, KCNQ1, NPPA, PKP2, PLN, RYR2, SCN1B, SCN3B, SCN4B, SCN5A, SLMAP, SNTA1, TGFB3, TMEM43

Long and Short QT AKAP9, ANK2, CACNA1C, CALM1, CALM2, CALM3, CAV3, KCNE1, KCNE2, KCNH2, KCNJ2, KCNJ5, KCNQ1, SCN4B, SCN5A, Syndromes SNTA1, TRDN

Brugada Syndrome CACNA1C, CACNB2, GPD1L, HCN4, KCNE3, SCN1B, SCN3B, SCN5A, SLMAP

Catecholaminergic polymorphic ventricular RYR2, CASQ2, KCNJ2 tachycardia

Arrhythmogenic Right Ventricular CDH2, CTNNA3, DES, DSC2, DSG2, DSP, JUP, LMNA, PKP2, PLN, RYR2, SCN5A, TGFB3, TMEM43, TTN Cardiomyopathy

ACTC1, ACTN2, ANKRD1, CALR3, CAV3, CRYAB, CSRP3, DES, FHL2, FLNC, GLA, JPH2, LAMP2, LDB3, MYBPC3, MYH6, MYH7, Hypertrophic MYL2, MYL3, MYLK2, MYPN, NEXN, PDLIM3, PLN, PRKAG2, SLC25A4, SOS1, TCAP, TNNC1, TNNI3, TNNT2, TPM1, TRIM63, Cardiomyopathy TTN, TTR, VCL

ABCC9, ACTC1, ACTN2, ANKRD1, BAG3, CRYAB, CSRP3, DES, DMD, DNAJC19, DOLK, DSC2, DSG2, DSP, EMD, EYA4, FKTN, Dilated Cardiomyopathy GATA4, GATAD1, ILK, LAMA4, LAMP2, LDB3, LMNA, MURC, MYBPC3, MYH6, MYH7, MYPN, NEBL, NEXN, PDLIM3, PKP2, PLN, PRDM16, RAF1, RBM20, SCN5A, SGCD, TAZ, TBX20, TCAP, TNNC1, TNNI3, TNNT2, TPM1, TTN, TTR, TXNRD2, VCL

Noonan and related BRAF, CBL, HRAS, KAT6B, KRAS, LZTR1, MAP2K1, MAP2K2, NF1, NRAS, PTPN11, RAF1, RASA2, RIT1, SHOC2, SOS1, SOS2, RASopathies SPRED1

ABCA3, ACVRL1, AP3B1, ASCL1, BDNF, BLOC1S3, BLOC1S6, BMPR2, CCDC39, CCDC40, CFTR, CSF2RA, CSF2RB, DKC1, DNAAF1, DNAAF2, DNAH11, DNAH5, DNAI1, DNAI2, DNAL1, DOCK8, DTNBP1, EDN3, EFEMP2, ELMOD2, ELN, ENG, FBLN5, Pulmonary Disease FBN1, FLCN, FOXF1, GDNF, HPS1, HPS3, HPS4, HPS5, HPS6, LTBP4, NKX2-1, NME8, NOP10, PARN, PHOX2B, RET, RSPH1, RSPH4A, RSPH9, RTEL1, SCNN1A, SCNN1B, SCNN1G, SERPINA1, SFTPA1, SFTPA2, SFTPB, SFTPC, SFTPD, SMAD9, STAT3, TERC, TERT, TINF2, TSC1, TSC2

Pulmonary Hypertension ACVRL1, BMPR1B, BMPR2, CAV1, EIF2AK4, ENG, FOXF1, GDF2, KCNA5, KCNK3, SMAD9

Familial Thoracic Aortic ACTA2, BGN, CBS, LOX, MAT2A, MFAP5, MYH11, MYLK Aneurysm

Ehlers Danlos Syndrome ADAMTS2, ATP7A, B3GALT6, B3GAT3, B4GALT7, CHST14, COL12A1, COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, DSE, and related disorders EFEMP2, ELN, FBLN5, FBN1, FKBP14, FLNA, GORAB, LTBP4, PLOD1, PRDM5, PYCR1, RIN2, SLC39A13, TNXB, ZNF469

Marfan, Loeys-Dietz, and COL3A1, COL5A1, COL5A2, EFEMP2, FBN1, FBN2, NOTCH1, SKI, SLC2A10, SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1, TGFBR2 related disorders

Familial APOB, GHR, LDLR, PCSK9 hypercholesterolemia

Congenital Heart CFC1, CITED2, CRELD1, FOXH1, GATA4, GATA6, GDF1, NKX2-5, NOTCH1, TBX1, TBX20, ZFPM2 Defects

Hereditary Hemorrhagic ACVRL1, ENG, GDF2, SMAD4 Telangiectasia

The gene content of our panels is continuously changing. Please visit www.lifelabsgenetics.com for the most up-to-date information.

Visit www.lifelabsgenetics.com to learn more about custom diagnostic panels, whole exome and whole genome sequencing. Contact us [email protected] | 1-84-GENEHELP (1-844-363-4357)