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2D6 Substrates 2D6 Inhibitors 2D6 Inducers
Physician Guidelines: Drugs Metabolized by Cytochrome P450’s 1 2D6 Substrates Acetaminophen Captopril Dextroamphetamine Fluphenazine Methoxyphenamine Paroxetine Tacrine Ajmaline Carteolol Dextromethorphan Fluvoxamine Metoclopramide Perhexiline Tamoxifen Alprenolol Carvedilol Diazinon Galantamine Metoprolol Perphenazine Tamsulosin Amiflamine Cevimeline Dihydrocodeine Guanoxan Mexiletine Phenacetin Thioridazine Amitriptyline Chloropromazine Diltiazem Haloperidol Mianserin Phenformin Timolol Amphetamine Chlorpheniramine Diprafenone Hydrocodone Minaprine Procainamide Tolterodine Amprenavir Chlorpyrifos Dolasetron Ibogaine Mirtazapine Promethazine Tradodone Aprindine Cinnarizine Donepezil Iloperidone Nefazodone Propafenone Tramadol Aripiprazole Citalopram Doxepin Imipramine Nifedipine Propranolol Trimipramine Atomoxetine Clomipramine Encainide Indoramin Nisoldipine Quanoxan Tropisetron Benztropine Clozapine Ethylmorphine Lidocaine Norcodeine Quetiapine Venlafaxine Bisoprolol Codeine Ezlopitant Loratidine Nortriptyline Ranitidine Verapamil Brofaramine Debrisoquine Flecainide Maprotline olanzapine Remoxipride Zotepine Bufuralol Delavirdine Flunarizine Mequitazine Ondansetron Risperidone Zuclopenthixol Bunitrolol Desipramine Fluoxetine Methadone Oxycodone Sertraline Butylamphetamine Dexfenfluramine Fluperlapine Methamphetamine Parathion Sparteine 2D6 Inhibitors Ajmaline Chlorpromazine Diphenhydramine Indinavir Mibefradil Pimozide Terfenadine Amiodarone Cimetidine Doxorubicin Lasoprazole Moclobemide Quinidine Thioridazine Amitriptyline Cisapride -
Systematic Review of the Effect of Intravenous Lipid Emulsion Therapy for Non-Local Anesthetics Toxicity
Clinical Toxicology ISSN: 1556-3650 (Print) 1556-9519 (Online) Journal homepage: http://www.tandfonline.com/loi/ictx20 Systematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicity Michael Levine, Robert S. Hoffman, Valéry Lavergne, Christine M. Stork, Andis Graudins, Ryan Chuang, Samuel J. Stellpflug, Martin Morris, Andrea Miller-Nesbitt, Sophie Gosselin & for the Lipid Emulsion Workgroup* To cite this article: Michael Levine, Robert S. Hoffman, Valéry Lavergne, Christine M. Stork, Andis Graudins, Ryan Chuang, Samuel J. Stellpflug, Martin Morris, Andrea Miller-Nesbitt, Sophie Gosselin & for the Lipid Emulsion Workgroup* (2016) Systematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicity, Clinical Toxicology, 54:3, 194-221, DOI: 10.3109/15563650.2015.1126286 To link to this article: http://dx.doi.org/10.3109/15563650.2015.1126286 Published online: 06 Feb 2016. Submit your article to this journal Article views: 692 View related articles View Crossmark data Citing articles: 2 View citing articles Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=ictx20 Download by: [UPSTATE Medical University Health Sciences Library] Date: 03 August 2016, At: 08:19 CLINICAL TOXICOLOGY, 2016 VOL. 54, NO. 3, 194–221 http://dx.doi.org/10.3109/15563650.2015.1126286 REVIEW Systematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicity Michael Levinea, Robert S. Hoffmanb, Vale´ry Lavergnec, Christine M. Storkd, Andis Graudinse, Ryan Chuangf, Samuel J. Stellpflugg, Martin Morrish, Andrea Miller-Nesbitth, Sophie Gosselini and for the Lipid Emulsion Workgroup* aDepartment of Emergency Medicine, Section of Medical Toxicology, University of Southern California, Los Angeles, CA, USA; bDivision of Medical Toxicology, Ronald O. -
H1-Antihistamines for Chronic Spontaneous Urticaria: an Abridged Cochrane Systematic Review
H1-antihistamines for chronic spontaneous urticaria: An abridged Cochrane Systematic Review Sharma, Maulina , Bennett, C. , Carter, Ben and Cohen, Stuart N. Author post-print (accepted) deposited by Coventry University’s Repository Original citation & hyperlink: Sharma, Maulina , Bennett, C. , Carter, Ben and Cohen, Stuart N. (2015) H1-antihistamines for chronic spontaneous urticaria: An abridged Cochrane Systematic Review . Journal of the American Academy of Dermatology, volume 73 (4): 710-716 http://dx.doi.org/10.1016/j.jaad.2015.06.048 DOI 10.1016/j.jaad.2015.06.048 ISSN 0190-9622 ESSN 1097-6787 Publisher: Elsevier NOTICE: this is the author’s version of a work that was accepted for publication in Journal of the American Academy of Dermatology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of the American Academy of Dermatology, [VOL 73, ISSUE 4, (2015)] DOI: 10.1016/j.jaad.2015.06.048 © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial- NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders. -
The EAACI/GA²LEN/EDF/WAO Guideline for the Definition, Classification, Diagnosis and Management of Urticaria
Accepted: 18 December 2017 DOI: 10.1111/all.13397 POSITION PAPER The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria T. Zuberbier1 | W. Aberer2 | R. Asero3 | A. H. Abdul Latiff4 | D. Baker5 | B. Ballmer-Weber6 | J. A. Bernstein7 | C. Bindslev-Jensen8 | Z. Brzoza9 | R. Buense Bedrikow10 | G. W. Canonica11 | M. K. Church1 | T. Craig12 | I. V. Danilycheva13 | C. Dressler14 | L. F. Ensina15 | A. Gimenez-Arnau 16 | K. Godse17 | M. Goncßalo18 | C. Grattan19 | J. Hebert20 | M. Hide21 | A. Kaplan22 | A. Kapp23 | C. H. Katelaris24 | E. Kocaturk€ 25 | K. Kulthanan26 | D. Larenas-Linnemann27 | T. A. Leslie28 | M. Magerl1 | P. Mathelier-Fusade29 | R. Y. Meshkova30 | M. Metz1 | A. Nast14 | E. Nettis31 | H. Oude-Elberink32 | S. Rosumeck14 | S. S. Saini33 | M. Sanchez-Borges 34 | P. Schmid-Grendelmeier6 | P. Staubach35 | G. Sussman36 | E. Toubi37 | G. A. Vena38 | C. Vestergaard39 | B. Wedi23 | R. N. Werner14 | Z. Zhao40 | M. Maurer1 | Endorsed by the following societies: AAAAI, AAD, AAIITO, ACAAI, AEDV, APAAACI, ASBAI, ASCIA, BAD, BSACI, CDA, CMICA, CSACI, DDG, DDS, DGAKI, DSA, DST, EAACI, EIAS, EDF, EMBRN, ESCD, GA²LEN, IAACI, IADVL, JDA, NVvA, MSAI, OGDV,€ PSA, RAACI, SBD, SFD, SGAI, SGDV, SIAAIC, SIDeMaST, SPDV, TSD, UNBB, UNEV and WAO* 1Charite—Universitatsmedizin€ Berlin, corporate member of Freie Universit€at Berlin, Humboldt-Universitat€ zu Berlin, and Berlin Institute of Health, Department of Dermatology and Allergy, Allergy-Centre-Charite, Berlin, Germany 2Department of Dermatology, Medical -
Second Generation Antiarrhythmic Agents: Have We Reached Antiarrhythmic Nirvana?
JACC Vol. 9. NO.2 459 February 1987:459-63 EDITORIAL REVIEWS Second Generation Antiarrhythmic Agents: Have We Reached Antiarrhythmic Nirvana? LEONARD N. HOROWITZ, MD, FACC, JOEL MORGANROTH, MD, FACC Philadelphia, Pennsylvania During the first half of the 20th century, antiarrhythmic some cases novel, but because their preapproval evaluations therapy was principally directed toward supraventricular ar followed a more rigorous and circumspect path. More in rhythmia; only relatively recently has therapy of ventricular formation is available to us so we can decide when and how arrhythmias been emphasized. In fact, significant pharma these agents should be employed. cologic treatment of ventricular arrhythmias was minimal Like all antiarrhythmic drugs of the first generation, the until routine use of quinidine and procainamide began in new agents have the potential to provoke or worsen ven the 1950s (1,2). The first generation oral antiarrhythmic tricular arrhythmias. These proarrhythmic effects vary in drugs, quinidine, procainamide and disopyramide, previ incidence and may present a major problem in certain patient ously constituted the principal antiarrhythmic agents for long groups such as those with sustained ventricular tachyar term treatment of ventricular arrhythmias in the United States. rhythrnias, reduced left ventricular function and conduction Compared with modem regulatory standards, the data on disturbances. In common with other antiarrhythmic drugs, which the use of these drugs was based were modest at best the second generation drugs have not been shown to prevent and rudimentary at worst. However, because good clinical sudden death in patients with ventricular ectopic activity. judgment compensates for a multitude of deficiencies, we These factors, along with efficacy and potential toxicity, have been able to provide effective antiarrhythmic therapy must be considered in selecting antiarrhythmic regimens for to many patients with this rather limited pharmacopoeia. -
Ventricular Tachycardia Drugs Versus Devices John Camm St
Cardiology Update 2015 Davos, Switzerland: 8-12th February 2015 Ventricular Arrhythmias Ventricular Tachycardia Drugs versus Devices John Camm St. George’s University of London, UK Imperial College, London, UK Declaration of Interests Chairman: NICE Guidelines on AF, 2006; ESC Guidelines on Atrial Fibrillation, 2010 and Update, 2012; ACC/AHA/ESC Guidelines on VAs and SCD; 2006; NICE Guidelines on ACS and NSTEMI, 2012; NICE Guidelines on heart failure, 2008; NICE Guidelines on Atrial Fibrillation, 2006; ESC VA and SCD Guidelines, 2015 Steering Committees: multiple trials including novel anticoagulants DSMBs: multiple trials including BEAUTIFUL, SHIFT, SIGNIFY, AVERROES, CASTLE- AF, STAR-AF II, INOVATE, and others Events Committees: one trial of novel oral anticoagulants and multiple trials of miscellaneous agents with CV adverse effects Editorial Role: Editor-in-Chief, EP-Europace and Clinical Cardiology; Editor, European Textbook of Cardiology, European Heart Journal, Electrophysiology of the Heart, and Evidence Based Cardiology Consultant/Advisor/Speaker: Astellas, Astra Zeneca, ChanRX, Gilead, Merck, Menarini, Otsuka, Sanofi, Servier, Xention, Bayer, Boehringer Ingelheim, Bristol- Myers Squibb, Daiichi Sankyo, Pfizer, Boston Scientific, Biotronik, Medtronic, St. Jude Medical, Actelion, GlaxoSmithKline, InfoBionic, Incarda, Johnson and Johnson, Mitsubishi, Novartis, Takeda Therapy for Ventricular Tachycardia Medical therapy Antiarrhythmic drugs Autonomic management Ventricular tachycardia Monomorphic Polymorphic Ventricular fibrillation Ventricular storms Ablation therapy Device therapy Surgical Defibrillation Catheter Antitachycardia pacing History of Antiarrhythmic Drugs 1914 - Quinidine 1950 - Lidocaine 1951 - Procainamide 1946 – Digitalis 1956 – Ajmaline 1962 - Verapamil 1962 – Disopyramide 1964 - Propranolol 1967 – Amiodarone 1965 – Bretylium 1972 – Mexiletine 1973 – Aprindine, Tocainide 1969 - Diltiazem 1975- Flecainide 1976 – Propafenone Encainide Ethmozine 2000 - Sotalol D-sotalol 1995 - Ibutilide (US) Recainam 2000 – Dofetilide US) IndecainideX Etc. -
H1-Antihistamines for Chronic Spontaneous Urticaria Sharma, M., Bennett, C., Cohen, S,N
H1-antihistamines for chronic spontaneous urticaria Sharma, M., Bennett, C., Cohen, S,N. and Carter, B. Published version deposited in CURVE November 2015 Original citation & hyperlink: Sharma, M., Bennett, C., Cohen, S,N. and Carter, B. (2014) H1-antihistamines for chronic spontaneous urticaria. Cochrane Database of Systematic Reviews, volume 2014 (11): Article number CD006137. http://dx.doi.org/10.1002/14651858.CD006137.pub2 Copyright © and Moral Rights are retained by the author(s) and/ or other copyright owners. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This item cannot be reproduced or quoted extensively from without first obtaining permission in writing from the copyright holder(s). The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the copyright holders. CURVE is the Institutional Repository for Coventry University http://curve.coventry.ac.uk/open H1-antihistamines for chronic spontaneous urticaria (Review) Sharma M, Bennett C, Cohen SN, Carter B This is a reprint of a Cochrane review, prepared and maintained by The Cochrane Collaboration and published in The Cochrane Library 2014, Issue 11 http://www.thecochranelibrary.com H1-antihistamines for chronic spontaneous urticaria (Review) Copyright © 2015 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. TABLE OF CONTENTS HEADER....................................... 1 ABSTRACT ...................................... 1 PLAINLANGUAGESUMMARY -
Formulation Development Strategies
FORMULATION DEVELOPMENT STRATEGIES FOR ORAL EXTENDED RELEASE DOSAGE FORMS Dissertation zur Erlangung des akademischen Grades des Doktors der Naturwissenschaften (Dr. rer. nat.) eingereicht im Fachbereich Biologie, Chemie, Pharmazie der Freien Universität Berlin vorgelegt von ARAYA RAIWA aus Bangkok, Thailand May, 2011 1. Gutachter: Prof. Dr. Roland Bodmeier 2. Gutachter: Prof. Dr. Jürgen Siepmann Disputation am 9.Juni 2011 TO MY FAMILY ACKNOWLEDGEMENTS First and foremost, I wish to express my deepest gratitude to my supervisor, Prof. Dr. Roland Bodmeier for his professional guidance, helpful advices and encouragement. I am very grateful for his scientific and financial support and for providing me such an interesting topic. Furthermore, I am very thankful to him for the opportunity to support his editorial role in the European Journal of Pharmaceutical Sciences. I would like to thank Prof. Dr. Jürgen Siepmann for co-evaluating this thesis. Thanks are extended to Prof. Dr. Herbert Kolodziej, Prof. Dr. Johannes Peter Surmann and Dr. Martin Körber for serving as members of my thesis advisor committee. I am particular thankful to Dr. Andrei Dashevsky, Dr. Nantharat Pearnchob and Dr. Martin Körber for their very useful discussion; Dr. Burkhard Dickenhorst for evaluating parts of this thesis; Mrs. Angelika Schwarz for her assistance with administrative issues; Mr. Andreas Krause, Mrs. Eva Ewest and Mr. Stefan Walter for the prompt and diligent technical support. Sincere thanks are extended to Dr. Ildiko Terebesi, Dr. Burkhard Dickenhorst, Dr. Soravoot Rujivipat and Dr. Samar El-Samaligy for the friendly atmosphere in the lab My special thanks are owing to all members from the Kelchstrasse for their practical advice, enjoyable discussion and kindness throughout the years. -
Development of a Bio Analytical Assay for the Determination of Rupatadine in Human Plasma and Its Clinical Applications
Acta Scientific Pharmaceutical Sciences (ISSN: 2581-5423) Volume 5 Issue 1 January 2021 Research Article Development of a Bio analytical Assay for the Determination of Rupatadine in Human Plasma and its Clinical Applications Sara AS2, Mohamed Raslan1,2, Eslam MS2 and Nagwa A Sabri1* Received: November 10, 2020 1Department of Clinical Pharmacy, Faculty of Pharmacy- Ain Shams University, Published: December 14, 2020 Cairo, Egypt © All rights are reserved by Nagwa A Sabri., 2Drug Research Centre, Cairo, Egypt et al. *Corresponding Author: Nagwa A Sabri, Department of Clinical Pharmacy, Faculty of Pharmacy- Ain Shams University, Cairo, Egypt. Abstract Background: Rupatadine is an antihistaminic drug that is used for the treatment of allergic rhinitis, chronic idiopathic urticarial, additionally, it can be used as safe and effective alternative to loratadine. Aim: Development of bio-analytical method for rapid quantification of rupatadine in human plasma and its clinical application in bioequivalenceMethods: study of generic and reference products of rupatadine 10mg film coated tablet. 0.5ml/min, ESI positive mode, and m/z 416282.1, 383337 for rupatadine and loratadine as internal standard respectively. The Extracted rupatadine was chromatographed with mobile phase of methanol: 0.5% formic acid 80:20 v/v at flow rate bioequivalence study was conducted in a crossover design invovlving 24 volunteers and pharmacokinetic parameters AUC 0-t, AUC 0-inf, Cmax, and Tmax were used for assessment of bioequivalence of the two products. Results: The average recovery of rupatadine from human plasma was 87.567%, limit of quantitation was 0.01ng/ml, and the cor- 2) obtained was 0.9997. -
ACC/AHA/ESC Practice Guideline
ACC/AHA/ESC Practice Guideline ACC/AHA/ESC Guidelines for the Management of Patients With Supraventricular Arrhythmias*—Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients With Supraventricular Arrhythmias) Developed in Collaboration With NASPE-Heart Rhythm Society Committee Members Carina Blomström-Lundqvist, MD, PhD, FACC, FESC, Co-chair; Melvin M. Scheinman, MD, FACC, Co-chair; Etienne M. Aliot, MD, FACC, FESC; Joseph S. Alpert, MD, FACC, FAHA, FESC; Hugh Calkins, MD, FACC, FAHA; A. John Camm, MD, FACC, FAHA, FESC; W. Barton Campbell, MD, FACC, FAHA; David E. Haines, MD, FACC; Karl H. Kuck, MD, FACC, FESC; Bruce B. Lerman, MD, FACC; D. Douglas Miller, MD, CM, FACC; Charlie Willard Shaeffer, Jr, MD, FACC; William G. Stevenson, MD, FACC; Gordon F. Tomaselli, MD, FACC, FAHA Task Force Members Elliott M. Antman, MD, FACC, FAHA, Chair; Sidney C. Smith, Jr, MD, FACC, FAHA, FESC, Vice-Chair; Joseph S. Alpert, MD, FACC, FAHA, FESC; David P. Faxon, MD, FACC, FAHA; Valentin Fuster, MD, PhD, FACC, FAHA, FESC; Raymond J. Gibbons, MD, FACC, FAHA†‡; Gabriel Gregoratos, MD, FACC, FAHA; Loren F. Hiratzka, MD, FACC, FAHA; Sharon Ann Hunt, MD, FACC, FAHA; Alice K. Jacobs, MD, FACC, FAHA; Richard O. Russell, Jr, MD, FACC, FAHA† ESC Committee for Practice Guidelines Members Silvia G. Priori, MD, PhD, FESC, Chair; Jean-Jacques Blanc, MD, PhD, FESC; Andzrej Budaj, MD, FESC; Enrique Fernandez Burgos, MD; Martin Cowie, MD, PhD, FESC; Jaap Willem Deckers, MD, PhD, FESC; Maria Angeles Alonso Garcia, MD, FESC; Werner W. -
Compounds and Bulk Powders
UnitedHealthcare Pharmacy Clinical Pharmacy Programs Program Number 2021 P 1014-13 Program Prior Authorization/Notification Medication Compounds and Bulk Powders P&T Approval Date 1/2012, 02/2013, 04/2013, 07/2013, 10/2013, 11/2013, 2/2014, 4/2014, 10/2014, 4/2015, 7/2015, 4/2016, 10/2016, 10/2017, 10/2018, 10/2019, 5/2020, 1/2021 Effective Date 4/1/2021; Oxford only: 4/1/2021 1. Background: Compounded medications can provide a unique route of delivery for certain patient- specific conditions and administration requirements. Compounded medications should be produced for a single individual and not produced on a large scale. A dollar threshold may be used to identify compounds which require Notification and must meet the criteria below in order to be covered. Drugs included in the compound must be a covered product. Claims for patients under the age of 6 will process automatically for First-Lansoprazole, First-Omeprazole, and Omeprazole + Syrspend SF compounding kits. 2. Coverage Criteriaa: A. Authorization for compounds and bulk powders will be approved based on all of the following criteria (includes bulk powders requested as a single ingredient such as bulk powder formulations of cholestyramine or nystatin when the powder formulation requested is not the commercially available FDA approved product): 1. The requested drug component is a covered medication -AND- 2. The requested drug component is to be administered for an FDA-approved indication -AND- 3. If a drug included in the compound requires prior authorization and/or step therapy, all drug specific clinical criteria must also be met -AND- 4. -
Draft for Public Comment
Draft for Public Comment Practice guideline update: Treatment of painful diabetic polyneuropathy Report of the Guideline Subcommittee of the American Academy of Neurology Authors (Alphabetical order—final order to be determined later in the guideline development process) Carmel Armon, MD, MSc, MHS1,Vera Bril, MD2, Brian C. Callaghan, MD, MS3, Lindsay Colbert, MA4, William S. David, MD, PhD5, Mary Dolan O’Brien, MLIS6, Kenneth Fink, MD, MPH7, Gary Franklin, MD, MPH8, Gary Gronseth, MD9, John Halperin, MD10, Lawrence B. Harkless, DPM11, Leslie Levine, PhD, VMD, JD12, Nicole Licking, DO13, Bruce A. Perkins, MD, MPH14, Michael Pignone, MD15, Raymond Price, MD16, Alexander Rae-Grant, MD17, Don Smith, MD18, Scott R. Wessels, MPS, ELS6 1. Department of Neurology, Tel Aviv University Sackler School of Medicine, Israel 2. Division of Neurology, Department of Medicine, Toronto General Hospital, ON, Canada 3. Department of Neurology, University of Michigan, Ann Arbor 4. The Foundation for Peripheral Neuropathy, Buffalo Grove, IL 5. Department of Neurology, Massachusetts General Hospital, Boston 6. American Academy of Neurology, Minneapolis, MN 7. Kamehameha Schools, Honolulu, HI 8. Department of Neurology, University of Washington, Seattle, WA 9. Department of Neurology, University of Kansas Medical Center, Kansas City 10. Department of Neurosciences, Overlook Medical Center, Summit, NJ 11. Western University Health Sciences College of Podiatric Medicine, Pomona, CA 1 Draft for Public Comment 12. Neuropathy Action Foundation, Santa Ana, CA 13. New West Physicians, Golden, CO 14. Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON 15. Department of Medicine, The University of Texas at Austin 16. Department of Neurology, University of Pennsylvania, Philadelphia 17.