Schwerpunkt 40 Jahre Pille
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University of Groningen the Pill and Thrombosis Van Vlijmen, Elizabeth
University of Groningen The pill and thrombosis van Vlijmen, Elizabeth Femma Willemien IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2016 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): van Vlijmen, E. F. W. (2016). The pill and thrombosis. Rijksuniversiteit Groningen. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license. More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne- amendment. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 08-10-2021 Financial support for the printing of this thesis was kindly provided by the Dutch Medicines Evaluation Board and UMCG/GUIDE. -
Cleaning up After Sex: an Environmental History of Contraceptives in the United States, 1873—2010 Sarah Ruth Payne
University of New Mexico UNM Digital Repository History ETDs Electronic Theses and Dissertations 9-3-2010 Cleaning Up After Sex: An Environmental History of Contraceptives in the United States, 1873—2010 Sarah Ruth Payne Follow this and additional works at: https://digitalrepository.unm.edu/hist_etds Recommended Citation Payne, Sarah Ruth. "Cleaning Up After Sex: An Environmental History of Contraceptives in the United States, 1873—2010." (2010). https://digitalrepository.unm.edu/hist_etds/62 This Dissertation is brought to you for free and open access by the Electronic Theses and Dissertations at UNM Digital Repository. It has been accepted for inclusion in History ETDs by an authorized administrator of UNM Digital Repository. For more information, please contact [email protected]. CLEANING UP AFTER SEX: AN ENVIRONMENTAL HISTORY OF CONTRACEPTIVES IN THE UNITED STATES, 1873–2010 BY SARAH R. PAYNE B.A., History, Nebraska Wesleyan University, 1997 M.A., History, University of Wyoming, 2001 DISSERTATION Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy History The University of New Mexico Albuquerque, New Mexico August, 2010 ACKNOWLEDGMENTS My heartfelt thanks go first and foremost to Dr. Virginia Scharff. For her encouragement, insight, and patience, with the dissertation and with life in general, I am truly grateful. Dr. Scharff’s skills as a researcher and writer are matched by her skills as a mentor, which have made possible the quality work of so many of her graduate students. I also thank Dr. Scharff and her Center for the Southwest for providing me funding and experience organizing lectures and workshops, and allowing me to work with so many wonderful scholars. -
Hormones and the Female Voice: an Exploration of the Female Hormonal Cycle from Puberty to Menopause and How It Affects the Vocal Apparatus
HORMONES AND THE FEMALE VOICE: AN EXPLORATION OF THE FEMALE HORMONAL CYCLE FROM PUBERTY TO MENOPAUSE AND HOW IT AFFECTS THE VOCAL APPARATUS A Dissertation Submitted to the Temple University Graduate Board In Partial Fulfillment of the Requirements for the Degree DOCTOR OF MUSICAL ARTS by Patricia Vigil July 2015 Examining Committee Members: Dr. Christine Anderson, Advisory Chair, Department of Voice and Opera Dr. Rollo Dilworth, Department of Music Education and Therapy Dr. Lawrence Indik, Department of Voice and Opera Dr. Joyce Lindorff, Department of Keyboard Studies © Copyright 2015 by Patricia Vigil All Rights Reserved ABSTRACT The purpose of this paper is to examine the female hormonal cycle throughout a woman’s life and its effects on the singing voice. Dealing with vocal issues brought on by hormonal fluctuations can be extremely frustrating for the professional singer, as these issues can wreak havoc on performance and practice schedules. The best weapon of defense against its unpredictability is information. Unfortunately, data on the female hormonal cycle and its effects on the voice is not covered in most standard vocal pedagogy books. Information on the subject is often relegated to a small section of a chapter, and even then usually describes only the symptoms: edema, hoarseness, and loss of high notes and power. The question as to why these symptoms happen every month and during menopause, and whether there is anything that can be done to alleviate them, remains largely unanswered. A candid discourse on the subject of hormones and the female voice has begun, but now must brought into the open. -
An Archaeology of Sex Hormones
Beyond the natural body Beyond the Natural Body presents an episode in the history of life sciences that is essential to our current understanding of sex and the body, and the relations between gender and science. Since the early decades of the twentieth century, the notion of the hormonally constructed body has become the dominant mode of conceptualizing bodies, particularly female bodies, to such an extent that we now assume that it is a natural phenomenon. This book challenges the idea that there is such a thing as a “natural” body and demonstrates that it is the process by which scientific claims achieve universal status that constructs such discourses as natural facts. Beyond the Natural Body tells the fascinating story of scientists’ search for the many tons of ovaries, testes and urine that were required in experiments to develop the hormonal body concept. It traces the origins of sex hormones and follows their development through mass-production as drugs to their eventual transformation into the contraceptive pill. Nelly Oudshoorn argues that the power to control sex and the body is not restricted to the domain of texts and ideologies. In addition, she describes the dynamic, capillary action of a science which linked cultural assumptions, concepts, ovaries, urine, diagnostic tests, laboratory equipment, marketing strategies, clinical trials, population policies and bodies, thus transforming the world we live in. Nelly Oudshoorn is Assistant Professor in the Department of Science Dynamics at the University of Amsterdam, and has written numerous articles on gender and biology. Beyond the natural body An archeology of sex hormones Nelly Oudshoorn London and New York First published 1994 by Routledge 11 New Fetter Lane, London EC4P 4EE This edition published in the Taylor & Francis e-Library, 2005. -
“Conceiving” the Pill the 45Th Birthday of the Oral Contraceptive Pill in Europe
Review Article “Conceiving” the pill The 45th birthday of the oral contraceptive pill in Europe Jean Calleja-Agius, Mark Brincat Abstract In 1931, Ludwig Haberlandt, Professor of Physiology In 1961, the first combined oral contraceptive pill was in Innsbruck, Austria wrote: ‘of all the methods available, introduced in Europe. This pill contained ethinylestradiol hormonal sterilisation, based on a biological principle, if it (0.05mg) and northisterone (4mg). Nowadays, monophasic pill can be applied unobjectively in the human, is the ideal method preparations contain a low dose (20–35 μg) of ethinylestradiol for practical medicine and its future task of birth control.’ His in combination with a progestogen. Progestogens include experiments involved transplanting ovaries from pregnant norethisterone and levonorgestrel (second generation); rabbits under the skin of fertile adult does, and he found that desogestrel and gestodene (third generation); and the they become infertile. newest progestogen, drospirenone (fourth generation). The three most well-known persons who are considered the Risks of the combined oral contraceptive pill include venous pioneers in the development of the oral contraceptive pill are thromboembolism and stroke. Benefits, such as protection Margaret Sanger, Katherine Dexter McCormick and Gregory from ovarian and endometrial cancer, apart from contraception, Goodwin Pincus. They had met in 1951 to initiate the project outweigh the risks if contraindications are observed, and low that resulted in marketing the first oral contraceptive. Margaret dose formulations used. Sanger was a nurse specialising in obstetric care, who introduced the term ‘birth control’ in 1914 in America through a monthly magazine entitled ‘The Woman Rebel’, which she edited. In 1950, Katherine Dexter McCormick, a philanthropist, sent a letter to Sanger indicating her interest in supporting ‘further contraceptive research.’ Both women had long been aware of the pressing social and population problems caused by the lack of adequate birth control. -
Combined Estrogen–Progestogen Contraceptives
COMBINED ESTROGEN–PROGESTOGEN CONTRACEPTIVES These substances were considered by a previous Working Group, in June 1998 (IARC, 1999), under the title ‘Oral contraceptives, combined’. Since that time, new data have become available, and these have been incorporated into the monograph and taken into consideration in the present evaluation. 1. Exposure Data 1.1 Introduction Combined hormonal contraceptives consist of an estrogen and a progestogen, and act primarily by preventing ovulation through the inhibition of follicle-stimulating hormone and luteinizing hormone. The progestogen component also renders the cervical mucus relatively impenetrable to sperm and reduces the receptivity of the endometrium to implantation. These mechanisms render combined hormonal contraceptives very effective in the preven- tion of pregnancy. Annual failure rates vary between 0.02% (two per 10 000 women/year) when full adherence to instructions for use is assumed (Ketting, 1988) and 5% for typical use (Fu et al., 1999). A variety of innovations have been developed since combined hormonal contra- ceptives were first made available in the late 1950s, but not all of these have proved valuable in practice. Changes in drug components, doses used and the temporal sequen- cing of exposure to drugs have incorporated new technologies and responded to suggested risks. While regional variations in use are abundant, the dominant trends have been towards less androgenic progestogens, lower doses of estrogen and progestogen, the near abandonment of hormonal contraceptives with an estrogen-only phase, a proliferation of different product formulations and the continuing development of novel delivery systems. In combined hormonal contraception, ethinylestradiol is the most common estrogen, although other are used occasionally. -
Oral Contraceptives, Combined
ORAL CONTRACEPTIVES, COMBINED 1. Exposure Combined oral contraceptives consist of the steroid hormone oestrogen in combi- nation with a progestogen, taken primarily to prevent pregnancy. The same hormones can also be used in other forms for contraception. Combined oral contraceptive pills generally refer to pills in which an oestrogen and a progestogen are given concurrently in a monthly cycle. In contrast, a cycle of sequential oral contraceptive pills includes oestrogen-only pills followed by five to seven days of oestrogen plus progestogen pills. Sequential oral contraceptive pills were removed from the consumer market in the late 1970s; they are covered in an IARC monograph (IARC, 1979, 1987). Combined oral contraceptives are thus usually administered as a pill containing oestrogen and progestogen, which is taken daily for 20–22 days, followed by a seven-day pill-free interval (or seven days of placebo), during which time a withdrawal bleed is expected to occur. The most commonly used oestrogen is ethinyloestradiol, although mestranol is used in some formulations. The pro- gestogens most commonly used in combined oral contraceptives are derived from 19-nor- testosterone and include norethisterone, norgestrel and levonorgestrel, although many others are available (Kleinman, 1990) (see Annex 2, Table 1). Chemical and physical data and information on the synthesis, production, use and regulations and guidelines for hormones used in combined oral contraceptives are given in Annex 1. Annex 2 (Table 1) lists the trade names of many contemporary combined oral contraceptives with their formulations. Combined oral contraceptives are currently available in monophasic, biphasic and triphasic preparations, the terms referring to the number of different doses of progestogen they contain. -
ORAL CONTRACEPTIVES, COMBINED 1. Exposure
ORAL CONTRACEPTIVES, COMBINED 1. Exposure Combined oral contraceptives consist of the steroid hormone oestrogen in combi- nation with a progestogen, taken primarily to prevent pregnancy. The same hormones can also be used in other forms for contraception. Combined oral contraceptive pills generally refer to pills in which an oestrogen and a progestogen are given concurrently in a monthly cycle. In contrast, a cycle of sequential oral contraceptive pills includes oestrogen-only pills followed by five to seven days of oestrogen plus progestogen pills. Sequential oral contraceptive pills were removed from the consumer market in the late 1970s; they are covered in an IARC monograph (IARC, 1979, 1987). Combined oral contraceptives are thus usually administered as a pill containing oestrogen and progestogen, which is taken daily for 20–22 days, followed by a seven-day pill-free interval (or seven days of placebo), during which time a withdrawal bleed is expected to occur. The most commonly used oestrogen is ethinyloestradiol, although mestranol is used in some formulations. The pro- gestogens most commonly used in combined oral contraceptives are derived from 19-nor- testosterone and include norethisterone, norgestrel and levonorgestrel, although many others are available (Kleinman, 1990) (see Annex 2, Table 1). Chemical and physical data and information on the synthesis, production, use and regulations and guidelines for hormones used in combined oral contraceptives are given in Annex 1. Annex 2 (Table 1) lists the trade names of many contemporary combined oral contraceptives with their formulations. Combined oral contraceptives are currently available in monophasic, biphasic and triphasic preparations, the terms referring to the number of different doses of progestogen they contain. -
Laughing Gas, Viagra, and Lipitor
Laughing Gas, Viagra, and Lipitor The Human Stories Behind the Drugs We Use Jie Jack Li 1 2006 3 Oxford University Press, Inc., publishes works that further Oxford University’s objective of excellence in research, scholarship, and education. Oxford New York Auckland Cape Town Dar es Salaam Hong Kong Karachi Kuala Lumpur Madrid Melbourne Mexico City Nairobi New Delhi Shanghai Taipei Toronto With offices in Argentina Austria Brazil Chile Czech Republic France Greece Guatemala Hungary Italy Japan Poland Portugal Singapore South Korea Switzerland Thailand Turkey Ukraine Vietnam Copyright © 2006 by Oxford University Press Published by Oxford University Press, Inc. 198 Madison Avenue, New York, New York 10016 www.oup.com Oxford is a registered trademark of Oxford University Press All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permission of Oxford University Press. Library of Congress Cataloging-in-Publication Data Li, Jie Jack. Laughing gas, viagra, and lipitor : the human stories behind the drugs we use / Jie Jack Li. p. cm. Includes bibliographical references and index. ISBN-13 978-0-19-530099-4 ISBN 0-19-530099-8 1. Drugs—Miscellanea. 2. Nitrous oxide. 3. Sildenafil. I. Title. RM301.15.L5 2006 362.29'9—dc22 2006002586 987654321 Printed in the United States of America on acid-free paper foreword ny person interested in understanding the history of medical A progress and the way in which many of the most important medi- cines came into existence will be well rewarded by reading this latest book by Jie Jack Li, one of the most prolific and interesting authors in the field of molecular medicine and chemistry. -
University of Groningen the Pill and Thrombosis Van Vlijmen, Elizabeth
University of Groningen The pill and thrombosis van Vlijmen, Elizabeth Femma Willemien IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2016 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): van Vlijmen, E. F. W. (2016). The pill and thrombosis. Rijksuniversiteit Groningen. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 23-09-2021 Chapter1 General introduction and outline of thesis Introduction Chapter 1 Introduction Combined oral contraceptives and venous thromboembolism The combined oral contraceptive, i.e. the ‘Pill’, was the first medicinal product developed that had to be taken every day on a regular basis by persons not suffe- ring from any disease. Today, world-wide more than 100 million women start the day with taking the ‘Pill’.1 Although the Pill is a safe and highly effective contracep- tive method in the vast majority of women, in a small group of women its use is associated with a rare but potentially serious adverse event, i.e. -
Oral Contraceptives - Journey So Far: a Review Kanaka Bhushanam GVVS1 and Sakuntala Devi Gampa2,*
REVIEW Oral contraceptives - journey so far: A review Kanaka Bhushanam GVVS1 and Sakuntala Devi Gampa2,* 1 2 Gitam Medical Collage, Gandhi Nagar, Rushikonda, Visakhapatnam, Andhra Pradesh, India Krishna Institute of Medical Sciences, Minister Road, Secunderabad-500003, Telangana, India Abstract since 1970s. As per WHO (1998), over 100 million women are using oral contraceptive pills (OCPs) worldwide, mostlyOral contraceptive in developed is acountries. widely accepted In India and only most 2% effectiveof married method women of offertility reproductive control. ageIts wereuse has using been OCPs growing for fertility control during the period from 1990 to 2001. The history, evolution and development of oral pills till Keywords:date is discussed oral contraception; along with the fertility benefits, control; risks and contraceptive side effects pills of oral contraceptive pills. *Corresponding author: Dr. Sakuntala Devi Gampa, Gitam Introduction Medical Collage, Gandhi Nagar, Rushikonda, Visakhapatnam, [email protected] Once upon a time contraception was a taboo in many countries and practicing or even promoting ReceivedAndhra Pradesh, 28 October India. 2015; Email: Revised 11 December 2015; Accepted 19 December 2015; Published 29 December 2015 contraception was punishable. From that situation oral pills have now reached a stage where they are Citation: most widely accepted method of birth control and Kanakabhushanam GVVS, Gampa SD. Oral1 contraceptives- also became a useful therapeutic modality for many journey so far: A review. J Med Sci Res. 2016; 4(1):35-40. DOI: gynaecological conditions avoiding unnecessary Chttp://dx.doi.org/10.17727/JMSR.2016/4-01opyright: © 2016 Kanakabhushanam GVVS, et al. Published by hysterectomies. Many breakthroughs in the article distributed under the terms of the Creative Commons evolution of birth pills are responsible for today’s AttributionKIMS Foundation License, and which Research permits Center. -
An Ethnography of Contraceptive Pill Users in a Central London Family Planning Clinic
The London School of Economics and Political Science The Social Life of the Pill: An Ethnography of Contraceptive Pill Users in a Central London Family Planning Clinic Victoria Jane Boydell A thesis submitted to the Department of Anthropology of the London School of Economics and Political Science for the degree of Doctor of Philosophy, London August 2010 1 UMI Number: U615975 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. Dissertation Publishing UMI U615975 Published by ProQuest LLC 2014. Copyright in the Dissertation held by the Author. Microform Edition © ProQuest LLC. All rights reserved. This work is protected against unauthorized copying under Title 17, United States Code. ProQuest LLC 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 48106-1346 THeses F BriVSh ttxury o' POW*C® ■jnd >.utfvjiv&.bciance IW t ? Declaration I certify that the thesis I have presented for examination for the MPhil/PhD degree of the London School of Economics and Political Science is solely my own work other than where I have clearly indicated that it is the work of others (in which case the extent of any work carried out jointly by me and any other person is clearly identified in it). The copyright of this thesis rests with the author. Quotation from it is permitted, provided that full acknowledgement is made.