The Symptoms of Post-Traumatic Stress Disorder
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Bionomics to Trial Drug Against Post-Traumatic Stress Disorder
ABN 53 075 582 740 ASX ANNOUNCEMENT 30 June 2016 BIONOMICS TO TRIAL DRUG AGAINST POST-TRAUMATIC STRESS DISORDER Trial to examine effects of Bionomics’ drug candidate BNC210 on PTSD No current effective treatments for PTSD 5-10% of population will suffer PTSD at some point ADELAIDE, Australia, 30 June 2016: Bionomics Limited (ASX:BNO; OTCQX:BNOEF), a biopharmaceutical company focused on the discovery and development of innovative therapeutics for the treatment of diseases of the central nervous system and cancer, has initiated a Phase II clinical trial with its drug candidate BNC210 in adults suffering Post- Traumatic Stress Disorder (PTSD). The study’s primary objective is to determine whether BNC210 causes a decrease in symptoms of PTSD as measured by the globally-accepted Clinician-Administered PTSD Scale (CAPS-5). Secondary objectives include the determination of the effects of BNC210 on anxiety, depression, quality of life, and safety. This clinical study will recruit 160 subjects with PTSD at 8-10 clinical research centres throughout Australia and New Zealand. The study is a randomized, double-blind, placebo-controlled design with subjects to be treated over 12 weeks with BNC210 or placebo. The Principal Investigator is Professor Jayashri Kulkarni from the Monash Alfred Psychiatry Research Centre in Melbourne, Australia. PTSD is very common and its societal and economic burden extremely heavy. It is estimated that 5-10% of the general population will suffer from PTSD at some point in their lives. There is a need for further and improved pharmacotherapy options for people with PTSD. Currently, only two drugs, the antidepressants paroxetine and sertraline, are approved for the treatment of PTSD. -
Persistent Neurobehavioral Problems Following Mild Traumatic Brain Injury
Archives of Clinical Neuropsychology 16 (2001) 561–570 Downloaded from https://academic.oup.com/acn/article/16/6/561/2043 by guest on 23 September 2021 Persistent neurobehavioral problems following mild traumatic brain injury Lawrence C. Hartlagea,*, Denise Durant-Wilsona, Peter C. Patcha,b aAugusta Neuropsychology Center, 4227 Evans to Locks Road, Evans, GA 30809, USA bUS Penitentiary, Atlanta, GA, USA Accepted 9 May 2000 Abstract Accumulating research documents typical rates in the range of 85% of mild traumatic brain injury (MTBI) showing prompt, complete resolution with 15% suffering from persistent neurobehavioral impairments. Studies of neurobehavioral symptoms of MTBI have not separated these two populations, resulting in either inconclusive or contradictory conclusions concerning the relationship of MTBI with residual behavioral problems. This project studied 70 MTBI patients with persistent neurobehavioral problems at two time intervals post-injury to determine whether there are consistent neurobehavioral patterns considered to be sequelae of MTBI. A matched group of 40 normal subjects provided control data. While most behavioral problems showed improvement, 21% tended to show significant behavioral impairment compared to controls at 12 or more months post-injury. Neurochemical bases of neuronal degeneration may account for some of the behavioral deterioration following MTBI. D 2001 National Academy of Neuropsychology. Published by Elsevier Science Ltd. Keywords: Persistent neurobehavioral problems; Brain; MTBI The scientific -
Depression and Anxiety: a Review
DEPRESSION AND ANXIETY: A REVIEW Clifton Titcomb, MD OTR Medical Consultant Medical Director Hannover Life Reassurance Company of America Denver, CO [email protected] epression and anxiety are common problems Executive Summary This article reviews the in the population and are frequently encoun- overall spectrum of depressive and anxiety disor- tered in the underwriting environment. What D ders including major depressive disorder, chronic makes these conditions diffi cult to evaluate is the wide depression, minor depression, dysthymia and the range of fi ndings associated with the conditions and variety of anxiety disorders, with some special at- the signifi cant number of comorbid factors that come tention to post-traumatic stress disorder (PTSD). into play in assessing the mortality risk associated It includes a review of the epidemiology and risk with them. Thus, more than with many other medical factors for each condition. Some of the rating conditions, there is a true “art” to evaluating the risk scales that can be used to assess the severity of associated with anxiety and depression. Underwriters depression are discussed. The various forms of really need to understand and synthesize all of the therapy for depression are reviewed, including key elements contributing to outcomes and develop the overall therapeutic philosophy, rationale a composite picture for each individual to adequately for the choice of different medications, the usual assess the mortality risk. duration of treatment, causes for resistance to therapy, and the alternative approaches that The Spectrum of Depression may be employed in those situations where re- Depression represents a spectrum from dysthymia to sistance occurs. -
A Comparison of Flashbacks and Ordinary Autobiographical
Behaviour Research and Therapy 42 (2004) 1–12 www.elsevier.com/locate/brat A comparison of flashbacks and ordinary autobiographical memories of trauma: content and language Steph J. Hellawell a,∗, Chris R. Brewin b a Royal Holloway, University of London, UK b University College, London, UK Received 12 November 2002; received in revised form 11 March 2003; accepted 12 March 2003 Abstract We investigated hypotheses derived from the dual representation theory of posttraumatic stress disorder, which proposes that flashbacks and ordinary memories of trauma are supported by different types of rep- resentation. Sixty-two participants meeting diagnostic criteria for posttraumatic stress disorder completed a detailed written trauma narrative, and afterwards identified those sections in the narrative that had been written in flashback and ordinary memory periods. As predicted, flashback periods were characterised by greater use of detail, particularly perceptual detail, by more mentions of death, more use of the present tense, and more mention of fear, helplessness, and horror. In contrast, ordinary memory sections were characterised by more mention of secondary emotions such as guilt and anger. 2003 Elsevier Ltd. All rights reserved. Keywords: Memory; PTSD; Trauma; Flashback; Narrative 1. Introduction The intense revisualizations of the traumatic scene (commonly known as “flashbacks”) reported by patients with posttraumatic stress disorder (PTSD) have been conceptualized both as a distinct form of memory (e.g., Brewin, 2001; Brewin, Dalgleish, & Joseph, 1996) and as a more frag- mented and disorganized form of ordinary autobiographical memory (Conway & Pleydell-Pearce, 2001; Foa & Riggs, 1993). Previously (Hellawell & Brewin, 2002) we presented evidence that parts of a trauma narrative labeled by PTSD patients as corresponding to periods of flashback ∗ Corresponding author. -
Living with Threats of Violence
Living with threats of violence People who are frequently exposed to violence or live with threats of violence may experience psychological, emotional, and physical effects. Whether the threat of violence is the result of living in a dangerous neighborhood or being involved in an abusive relationship, common reactions include fear, depression, anxiety, and post-traumatic stress disorder. These stress reactions are normal but can seriously interfere with everyday life and the ability to function at home, work, or school. Common reactions Coping with stress and anxiety If the threat of violence and conflict is constant Living with the threat of violence is an unfortunate and unpredictable, people may operate in “survival reality for many people around the world. Ways to mode” and find it difficult to focus on anything but manage stress and anxiety include the following: the looming threat. For most people, being physically • Take care of yourself first. Eat healthy foods, get threatened is a traumatic event. Emotional and enough rest, and exercise on a regular basis. physical responses to traumatic events may include: Physical activity can relieve anxiety and promote • Shock, confusion, and intense fear well-being. • Anxiety and sadness • Talk about your concerns with people you trust. A • Physical reactions such as headaches, supportive network is very important for emotional stomachaches, chest pains, racing pulse, dizzy health. spells, trouble sleeping and changes in appetite • Avoid excessive use of caffeine, alcohol and • Being easily startled nicotine. • Feelings of anger, guilt, despair, and self-blame • Balance work and play. Make time for hobbies and activities you enjoy, or find interesting volunteer • Difficulty concentrating work. -
Compreheneon of Time. SPONS AGENCY North Carolina Univ., Greensboro
DOCUMENT RESUla ED 273 394 PS 016 064 AUTHOR Calvert, Sandra L.; Scott, N. Catherine TITLE Television Production Feature Effects on Children's Compreheneon of Time. SPONS AGENCY North Carolina Univ., Greensboro. PUB DATE Aug 86 NOTE 16p.; Paper presented at the Annual Meeting of the American Psychological Association (Washington, DC, August 22-26, 1986). PUB TYPE Reports - Research/Technical (143) -- Speeches/Conference Papers (150) EDRS PRICE MF01/PC01 Plus Postage. DESCRIPTORS Age Differences; *Audi,ory Stimuli; *Comprehension; Elementary Education; *Elementary School Students; Sex Differences; *Television Viewing; *Time; *Visual Stimuli ABSTRACT Children's temporal comprehension was assessed after viewing a television program containing flashbacks that shifted the events to much earlier times. Flashbacks were marked or not marked with sound effects, and time relations were represented with either dreamy dissolves or abrupt camera cuts. A total of 64 children, equally distributed by sex and by grades kindergarten and first versus fourth and fifth, participated in individual viewing sessions. After viewing, children sequenced picture sets to assess temporal integration of the plot line and answered questions to assess comprehension of the flashbacks. Results indicated that young children understood temporal concepts best after viewing camera dissolves, but older boys understood concepts of real time best after viewing camera cuts. The results suggest that formal features differentially activate mental skills, depending on children's -
Ethics Questions Raised by the Neuropsychiatric
REGULAR ARTICLE Ethics Questions Raised by the Neuropsychiatric, Neuropsychological, Educational, Developmental, and Family Characteristics of 18 Juveniles Awaiting Execution in Texas Dorothy Otnow Lewis, MD, Catherine A. Yeager, MA, Pamela Blake, MD, Barbara Bard, PhD, and Maren Strenziok, MS Eighteen males condemned to death in Texas for homicides committed prior to the defendants’ 18th birthdays received systematic psychiatric, neurologic, neuropsychological, and educational assessments, and all available medical, psychological, educational, social, and family data were reviewed. Six subjects began life with potentially compromised central nervous system (CNS) function (e.g., prematurity, respiratory distress syndrome). All but one experienced serious head traumas in childhood and adolescence. All subjects evaluated neurologically and neuropsychologically had signs of prefrontal cortical dysfunction. Neuropsychological testing was more sensitive to executive dysfunction than neurologic examination. Fifteen (83%) had signs, symptoms, and histories consistent with bipolar spectrum, schizoaffective spectrum, or hypomanic disorders. Two subjects were intellectually limited, and one suffered from parasomnias and dissociation. All but one came from extremely violent and/or abusive families in which mental illness was prevalent in multiple generations. Implications regarding the ethics involved in matters of culpability and mitigation are considered. J Am Acad Psychiatry Law 32:408–29, 2004 The first well-documented case in America of execut- principle, the New Jersey Supreme Court, in the case ing a child antedates the American Revolution. In of State v. Aaron,5 overturned the death sentence of 1642, a 16-year-old boy, Thomas Graunger, was an 11-year-old slave convicted of murdering a hanged for the crime of bestiality, having sodomized younger child. -
Post-Traumatic Stress Disorder (PTSD) and Sleep
SHF-PTSD-0312 21/3/12 6:20 PM Page 1 Post-Traumatic Stress Disorder (PTSD) and Sleep Important Things to Know About PTSD and Sleep • PTSD can happen after a period of extreme trauma and stress. • One of the symptoms of PTSD may be problems with sleeping. • The treatment for this will depend on how the PTSD is affecting sleep. • There are many treatments available. How might PTSD affect sleep? • Insomnia. People with PTSD may have difficulty with getting to sleep or staying asleep. They may wake up There are may sleep problems that may be associated frequently during the night and be unable to get back with PTSD. For more information on the disorders to sleep. mentioned below see the relevant pages on this website. • Issues linked to the body clock, such as Delayed Sleep • The extreme anxiety of PTSD (caused by trauma or Phase Disorder may occur in a person with PTSD. If you catastrophe) can seriously disrupt sleep. In some cases can’t get to sleep until very late at night and then this starts a few months after the event. You might need to sleep in you may be experiencing this suffer from horror or strong fear and feel helpless. See problem. Anxiety and Sleep. • Obstructive Sleep Apnoea may be caused by weight • People with PTSD have higher rates of depression and gain due to the life style changes associated with the this is often associated with poor sleep. See PTSD. If the sleep apnoea is serious, medications such Depression and Sleep. as Seroquel can be an additional danger. -
Major Depressive and Generalized Anxiety Disorder
MAJOR DEPRESSIVE DISORDER AND GENERALIZED ANXIETY DISORDER Dana Bartlett, RN, BSN, MSN, MA Dana Bartlett is a professional nurse and author. His clinical experience includes 16 years of ICU and ER experience and over 20 years of as a poison control center information specialist. Dana has published numerous CE and journal articles, written NCLEX material and textbook chapters, and done editing and reviewing for publishers such as Elsevier, Lippincott, and Thieme. He has written widely on the subject of toxicology and was recently named a contributing editor, toxicology section, for Critical Care Nurse journal. He is currently employed at the Connecticut Poison Control Center and is actively involved in lecturing and mentoring nurses, emergency medical residents and pharmacy students. ABSTRACT Major depressive disorder and generalized anxiety disorder are psychiatric conditions with primary symptoms that often overlap. The treatment of each condition is often similar. Medication, psychotherapy and lifestyle changes are typically recommended as part of the patient treatment plan. Although often diagnosed as separate conditions, major depressive disorder and generalized anxiety disorder often co- occur, and thoughtful consideration by psychiatric and primary care providers and nurses of selective treatment strategies to target primary symptoms will support patient compliance, progress and remission. nursece4less.com nursece4less.com nursece4less.com nursece4less.com 1 Continuing Nursing Education Course Planners William A. Cook, PhD, Director, Douglas Lawrence, MA, Webmaster, Susan DePasquale, MSN, FPMHNP-BC, Lead Nurse Planner Policy Statement This activity has been planned and implemented in accordance with the policies of NurseCe4Less.com and the continuing nursing education requirements of the American Nurses Credentialing Center's Commission on Accreditation for registered nurses. -
Which Is It: ADHD, Bipolar Disorder, Or PTSD?
HEALINGHEALINGA PUBLICATION OF THE HCH CLINICIANS’ HANDSHANDS NETWORK Vol. 10, No. 3 I August 2006 Which Is It: ADHD, Bipolar Disorder, or PTSD? Across the spectrum of mental health care, Anxiety Disorders, Attention Deficit Hyperactivity Disorders, and Mood Disorders often appear to overlap, as well as co-occur with substance abuse. Learning to differentiate between ADHD, bipolar disorder, and PTSD is crucial for HCH clinicians as they move toward integrated primary and behavioral health care models to serve homeless clients. The primary focus of this issue is differential diagnosis. Readers interested in more detailed clinical information about etiology, treatment, and other interventions are referred to a number of helpful resources listed on page 6. HOMELESS PEOPLE & BEHAVIORAL HEALTH Close to a symptoms exhibited by clients with ADHD, bipolar disorder, or quarter of the estimated 200,000 people who experience long-term, PTSD that make definitive diagnosis formidable. The second chronic homelessness each year in the U.S. suffer from serious mental causative issue is how clients’ illnesses affect their homelessness. illness and as many as 40 percent have substance use disorders, often Understanding that clinical and research scientists and social workers with other co-occurring health problems. Although the majority of continually try to tease out the impact of living circumstances and people experiencing homelessness are able to access resources comorbidities, we recognize the importance of causal issues but set through their extended family and community allowing them to them aside to concentrate primarily on how to achieve accurate rebound more quickly, those who are chronically homeless have few diagnoses in a challenging care environment. -
An Evidence Based Guide to Anxiety in Autism
Academic excellence for business and the professions The Autism Research Group An Evidence Based Guide to Anxiety in Autism Sebastian B Gaigg, Autism Research Group City, University of London Jane Crawford, Autism and Social Communication Team West Sussex County Council Helen Cottell, Autism and Social Communication Team West Sussex County Council www.city.ac.uk November 2018 Foreword Over the past 10-15 years, research has confirmed what many parents and teachers have long suspected – that many autistic children often experience very significant levels of anxiety. This guide provides an overview of what is currently known about anxiety in autism; how common it is, what causes it, and what strategies might help to manage and reduce it. By combining the latest research evidence with experience based recommendations for best practice, the aim of this guide is to help educators and other professionals make informed decisions about how to promote mental health and well-being in autistic children under their care. 3 Contents What do we know about anxiety in autism? 5 What is anxiety? 5 How common is anxiety and what does it look like in autism? 6 What causes anxiety in autism? 7-9 Implications for treatment approaches 10 Cognitive Behaviour Therapy 10 Coping with uncertainity 11 Mindfulness based therapy 11 Tools to support the management of anxiety in autism 12 Sensory processing toolbox 12-13 Emotional awareness and alexithymia toolbox 14-15 Intolerance of uncertainty toolbox 16-17 Additional resources and further reading 18-19 A note on language in this guide There are different preferences among members of the autism community about whether identity-first (‘autistic person’) or person-first (‘person with autism’) language should be used to describe individuals who have received an autism spectrum diagnosis. -
Adjustment Disorder
ADJUSTMENT DISORDER Introduction Recent Changes from the DSM-IV to the DSM-5 Prevalence Causes and Risk Factors Classifications Diagnosis Comorbidity Treatment Psychotherapy Pharmacological Treatment Cultural Considerations Overview for Families Introduction An adjustment disorder is an unhealthy behavioral response to a stressful event or circumstance (Medical Center of Central Georgia, 2002). Youth who experience distress in excess of what is an expected response may experience significant impairment in normal daily functioning and activities (Institute for Health, Health Care Policy and Aging Research, 2002). Adjustment disorders in youth are created by factors similar to those in adults. Factors that may contribute to the development of adjustment disorders include the nature of the stressor and the vulnerabilities of the child, as well as other intrinsic and extrinsic factors (Benton & Lynch, 2009). In order to be diagnosed as an adjustment disorder, the child’s reaction must occur within three months of the identified event (Medical Center of Central Georgia, 2002). Typically, the symptoms do not last more than six months, and the majority of children quickly return to normal functioning (United Behavioral Health, 2002). Adjustment disorders differ from post-traumatic stress disorder (PTSD) in that PTSD usually occurs in reaction to a life-threatening event and may last longer (Access Med Health Library, 2002). Adjustment disorders may be difficult to distinguish from major depressive disorder (Casey & Doherty, 2012). Unless otherwise cited, the following information is attributed to the University of Chicago Comer Children’s Hospital (2005). In clinical samples of children and adolescents, males and females are equally likely to be diagnosed with an adjustment disorder (American Psychiatric Association [APA], 2000).