DOCSLIB.ORG

Redalyc.CPAP Treatment for Catathrenia

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Redalyc.CPAP Treatment for Catathrenia Revista Portuguesa de Pneumología ISSN: 0873-2159 [email protected] Sociedade Portuguesa de Pneumologia Portugal Dias, C.; Sousa, L.; Batata, L.; Teixeira, F.; Moita, J.; Moutinho dos Santos, J. CPAP treatment for catathrenia Revista Portuguesa de Pneumología, vol. 23, núm. 2, marzo-abril, 2017, pp. 101-104 Sociedade Portuguesa de Pneumologia Lisboa, Portugal Available in: http://www.redalyc.org/articulo.oa?id=169750147009 How to cite Complete issue Scientific Information System More information about this article Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Journal's homepage in redalyc.org Non-profit academic project, developed under the open access initiative Documento descargado de http://www.elsevier.pt el 28/03/2017. Copia para uso personal, se prohíbe la transmisión de este documento por cualquier medio o formato. RESEARCH LETTERS 101 Conflicts of interest randomised controlled trial of efficacy, feasibility and costs. Respir Med. 2014;108:1387---95. The authors have no conflicts of interest to declare. J.C. Winck a,∗, J. Chaves Caminha b a References Faculdade de Medicina da Universidade do Porto, Portugal b Instituto de Ciências Biomédicas Abel Salazar, 1. Nava S. Behind a mask: tricks, pitfalls and preju- Universidade do Porto, Portugal dices for non invasive ventilation. Respir Care. 2013;58: 1367---76. ∗ Corresponding author. 2. Köhnlein T, Windisch W, Köhler D, Drabik A, Geiseler J, Hartl S, E-mail address: [email protected] (J.C. Winck). et al. Non-invasive positive pressure ventilation for the treat- ment of severe stable chronic obstructive pulmonary disease: a http://dx.doi.org/10.1016/j.rppnen.2015.12.008 prospective, multicentre, randomised, controlled clinical trial. 2173-5115/ Lancet Respir Med. 2014;2:698---705. © 2016 Sociedade Portuguesa de Pneumologia. Published by Elsevier 3. Hazenberg A, Kerstjens HA, Prins SC, Vermeulen KM, Wijk- Espa na,˜ S.L.U. This is an open access article under the CC BY-NC-ND stra PJ. Initiation of home mechanical ventilation at home: a license (http://creativecommons.org/licenses/by-nc-nd/4.0/ ). CPAP treatment for catathrenia home with the established pressure. The patients were eval- uated at 1 and 3 months of CPAP therapy, in the presence of Catathrenia is a rare, idiopathic sleep disorder classified as their bed partner. During the evaluation, patients were ques- an isolated symptom of sleep-disordered breathing (SDB). 1 tioned how they would classify their daytime complaints Its prevalence is unknown, 2 and its onset is usually in improvement (scale 0---100). After the first 3 months of adolescence. 3 Affected individuals are frequently unaware CPAP therapy, they were contacted monthly by telephone of their problem, and family members or bed partners to evaluate improvements over the remaining 3 months of commonly report strange sounds while breathing during therapy. sleep. 1,3 Eight patients were included. Five patients had abnor- The hallmark of this disorder is a deep inspiration mal sleepiness (ESS > 10). Six patients had symptoms of followed by prolonged expiration and a monotonous vocal- anxiety disorder and 7 were medicated with psycopharms ization resembling groaning, usually during rapid eye (Table 1). movement sleep. 1 Catathrenia events during the diagnostic and CPAP titra- No pharmacological treatments are available, 4 but some tion polysomnograms are displayed on Table 2. Diagnostic studies have shown partial or complete resolution of events PSG showed a mean respiratory disturbance index (RDI) with continuous positive airway pressure (CPAP) therapy, of 2.8 ± 3.29 events/h, a mean apnea---hypopnea index of especially in patients with a SDB associated. 2,4,5 1.2 ± 1.5 events/h. The mean number of catathrenia events The purpose of this study was to assess the effectiveness was 39.3 ± 26.6. Patient #6 experienced a partial resolution of CPAP treatment and a 6-month CPAP therapy in patients of events, despite an increase in pressure up to 12 cmH 2O. with catathrenia without SDB events associated. This patient did not tolerate a higher pressure. We performed a prospective study of patients with After 1 month of therapy, seven patients had signifi- catathrenia, diagnosed between 2008 and 2014, who under- cantly fewer moaning/groaning episodes and patient #6 went a CPAP titration PSG and subsequently initiated home reported a moderate reduction. After 3 months, seven CPAP therapy for 6 months. There were no exclusion patients reported complete resolution of nocturnal episodes criteria. and patient #6 reported maintenance of the moderate During anamnesis, the evaluated symptoms were: groan- reduction achieved with the first month of therapy. An ing, snoring, choking, apnea, daytime sleepiness (Epworth improvement in daytime complaints was reported by all Sleepiness Scale [ESS]), headache, fatigue, and anxi- patients (mean subjective improvement of 80/100). One ety/depression. The diagnosis was based on an overnight patient maintained an abnormal sleepiness (ESS > 10). Com- polysomnogram (PSG). A catathrenia event was defined as plete resolution of events was maintained during the 6 a deep inhalation followed by prolonged exhalation, and months of follow-up, except for patient #6 who continued to a monotonous vocalization resembling groaning. 1 After the exhibit partial improvement. This patient was subsequently diagnostic study, patients underwent a CPAP titration PSG treated with clonazepam for 6 months, but showed no addi- to correct catathrenia events. CPAP began at 4 cmH 2O and tional improvements. was progressively increased according to the type of respira- Although CPAP titration has been used in previous studies tory events observed. In the presence of obstructive events, of catathrenia, its goal was to correct apnea, hypopnea, and such as obstructive apnea or hypopnea, the pressure was flow limitation. 2,5 Other studies have reported an improve- increased by 2 cmH 2O every 15 min, and in the presence of ment in moaning/groaning with CPAP, but the majority of snoring, respiratory effort-related arousals, and/or groan- patients had associated SDB. 2,4 6 ing episodes, it was increased by 1 cmH 2O every 15 min, Iriarte et al. have argued that the pathological mech- until the events reduced in number or disappeared. Once anism underlying catathrenia is mainly obstructive. Our the optimal pressure was achieved, CPAP was initiated at results support this theory, as our patients responded to Documento descargado de http://www.elsevier.pt el 28/03/2017. Copia para uso personal, se prohíbe la transmisión de este documento por cualquier medio o formato. 102 Table 1 Demographic and clinical characteristics of patients. Patient Sex Age (years) BMI (kg/m 2) Chief Onset of Other Craniofacial Psycopharms ESS score complaint groaning symptoms examination 1 F 40 21.4 Groaning, Childhood Choking, Mallampati I, Paroxetine 13 excessive morning high narrow daytime headache, hard palate sleepiness panic attack, 2 F 25 27.7 Groaning, Childhood Morning Mallampati I, Ethyl 14 fatigue headache, deviated nasal loflazepate, panic attack septum trazodone 3 F 37 39.5 Groaning, 15 years of Depression Mallampati II, Paroxetine, 20 snoring, age long uvula Lorazepam, choking Trazodone 4 F 30 22 Groaning Childhood Tension Mallampati II, Cloxazolam 11 headache tonsillectomy 5 M 31 26 Groaning 25 years of Morning Mallampati II, --- 4 age headache and long uvula fatigue 6 M 32 27.2 Groaning, 28 years of Apnea, Mallampati I, Sertraline, 4 morning age depression High narrow alprazolan fatigue and hard palate headache 7 F 36 45.8 Groaning 26 years of Headache, Mallampati I Alprazolam 3 age fatigue, depression 8 F 34 18.2 Groaning 32 years of Choking, Mallampati I, Fluoxetine, 14 age morning high narrow alprazolam fatigue, hard palate, anxiety short uvula F --- female; M --- male; BMI --- body mass index; ESS --- Epworth Sleepiness Scale. RESEARCH LETTERS Documento descargado de http://www.elsevier.pt el 28/03/2017. Copia para uso personal, se prohíbe la transmisión de este documento por cualquier medio o formato. RESEARCH LETTERS 103 positive airway pressure. Vetrugno et al. 3 described a series of 10 patients with catathrenia and a normal RDI (as CPAP our patients) who had a post-inspiratory positive rise in 7 7 5 4 5 2 ESS After 12 10 endoesophageal pressure during events, higher than that movement; observed in expiration in eupnoic breathing, suggesting eye an expiratory upper airway obstruction. One possible CPAP mechanism that might explain the response observed in our 3 rapid patients is subtotal closure of the glottis during expiration. 0 0 0 0 0 0 0 (s) Maximum duration under 14 --- Our patients presented some differences in relation to REM previous published series: there was a preponderance of CPAP women; OSA was absent and the majority of patients were time; sleepy. It is possible that patients with more severe SDB, 0 0 0 0 0 8 0 0 (s) Minimum duration under PSG catathrenia events were unnoticed or obscured by other sleep respiratory sounds and therefore not detected. This may CPAP explain the lower prevalence in men and patients with Titration total OSA in our series. The higher frequency of young women --- 0 0 0 0 0 9 0 0 Catathrenia events under (total) is also probably related to the less severe SDB. As for TST sleepiness, it may be argued that it may be related to the O) concomitant psychiatric disorders and medications. Other CPAP 2 during index; sleepiness causes, recognized to contribute to sleep depri- used Peak 7 6 6 8 9 8 7 titration (cmH sound. 12 vation, were not analyzed in the present study. However, its improvement following efficacious catathrenia treat- 0.2 0.4 6.1 3.1 7 0.3 5 4.8 RDI ment suggest an association between both complaints and groaning s) warrants further research. While no clear association has a been demonstrated between catathrenia and psychiatric apnea/hypopnea 1 0 disorders, they marked a bold presence in our study (7/8 --- Clusters duration (mean, 59 23 15 76 56 80 67 patients).
Load more

Recommended publications
  • How to Take a Sleep History
    1/25/2015 How to take a sleep history Joan Santamaria Neurology Service and Multidisciplinary Sleep Disorders Unit Hospital Clínic of Barcelona 1.- Clinical history: Fundamental: the best “sleep test” Examination: helpful, but not always 2.- Investigations : Sleep tests: PSG, Video-PSG, respiratory polygraphy, MSLT, MWT, actimetry 3.- To rush into a sleep test without considering the history is of little use Taking a good sleep history The bed partner is essential By definition, people is unconscious during sleep Parasomnias, PLMs, Snoring, Sleep apnea, Seizures Daytime sleepiness may be neglected by some patients Even in insomnia patients, the bed partner information may be helpful 1 1/25/2015 Three main complaints I cannot sleep as much as I want (insomnia) Excessive daytime sleepiness (hypersomnia) Abnormal behaviors during sleep (parasomnias and other problems…noise, apnea, enuresis, seizures… ) What are the main questions? Nocturnal sleep characteristics Schedule of sleep during the week and week-end or holidays Latency to sleep, number of awakenings and cause (bathroom, pain, nightmare...) Time and type of final awakening (spontaneous/induced) Feel refreshed / tired on awakening? 23 1 4:30 6 8 Nocturnal sleep pattern Sleep onset insomnia 24 1:30 7:30 Delayed sleep phase 24 3 12 Week day Insufficient sleep 24 5:30 1 11 Week end (> 2 hrs additional sleep duration on week ends, high sleep efficiency) 2 1/25/2015 Sleep diary DEFINITION OF INSOMNIA Two key elements Nocturnal sleep: Difficulty in sleeping as much or as deep as one would
    [Show full text]
  • Parasomnias Revisited New Mexico Thoracic Society Sapna Bhatia Md 02/25/17 Objectives
    PARASOMNIAS REVISITED NEW MEXICO THORACIC SOCIETY SAPNA BHATIA MD 02/25/17 OBJECTIVES • Appreciate the clinical semiology to help differentiate between REM and NREM parasomnias • Appreciate the ICSD III Classification Scheme for the major parasomnias • Understand management modalities including behavioral and pharmacological for NREM and REM parasomnias • Understand the difference between parasomnias and seizures WHAT ARE PARASOMNIAS? Undesirable motor, or verbal phenomena that arise from sleep or sleep-wake transition PARASOMNIAS: OVERLAPPING STATES REM PARASOMNIAS WAKE NREM PARASOMNIAS REM NREM PARASOMNIAS: DIFFERENTIAL DIAGNOSIS RBD Confusional Arousals Recurrent Isolated Sleep Paralysis Sleepwalking Nightmare Disorder Sleep Terrors WAKE Sleep Related Eating Disorder REM NREM PYSCHOGENIC SEIZURES SPELLS NFLE Dissociative Disorder ICSD II ICSD III REM Parasomnias • RBD • RBD • Recurrent Isolated Sleep • Recurrent Isolated Sleep Paralysis ICSD II VS ICSDParalysis III CLASSIFICATION• Nightmare Disorder • Nightmare Disorder Disorders of arousal • Confusional Arousals • Confusional Arousals (NREM sleep) • Sleepwalking • Sleep Walking • Sleep Terrors • Sleep Terrors • SRED Other Parasomnias • SRED • Sleep Related Dissociative • Sleep Related Dissociative Disorders Disorders • Sleep Enuresis • Sleep Enuresis • Catathrenia SDB • Catathrenia • Exploding Head Syndrome • Exploding Head syndrome • Sleep Related Hallucinations • Sleep Related Hallucinations • Parasomnia, Unspecified • Parasomnia, Unspecified • Parasomnia due to Drug or • Parasomnia
    [Show full text]
  • Parasomnias and Antidepressant Therapy: a Review of the Literature
    REVIEW ARTICLE published: 12 December 2011 PSYCHIATRY doi: 10.3389/fpsyt.2011.00071 Parasomnias and antidepressant therapy: a review of the literature Lara Kierlin1,2 and Michael R. Littner 1,2* 1 David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA 2 Pulmonary, Critical Care and Sleep Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA Edited by: There exists a varying level of evidence linking the use of antidepressant medication to Ruth Benca, University of the parasomnias, ranging from larger, more comprehensive studies in the area of REM Wisconsin – Madison School of Medicine, USA sleep behavior disorder to primarily case reports in the NREM parasomnias. As such, prac- Reviewed by: tice guidelines are lacking regarding specific direction to the clinician who may be faced Ruth Benca, University of with a patient who has developed a parasomnia that appears to be temporally related to Wisconsin – Madison School of use of an antidepressant. In general, knowledge of the mechanisms of action of the med- Medicine, USA ications, particularly with regard to the impact on sleep architecture, can provide some David Plante, University of Wisconsin, USA guidance. There is a potential for selective serotonin reuptake inhibitors, tricyclic antide- *Correspondence: pressants, and serotonin–norepinephrine reuptake inhibitors to suppress REM, as well Michael R. Littner, 10736 Des Moines as the anticholinergic properties of the individual drugs to further disturb normal sleep Avenue, Porter Ranch, Los Angeles, architecture. CA 91326, USA. e-mail: [email protected] Keywords: parasomnias, REM sleep behavior disorder, non-REM parasomnias, selective serotonin reuptake inhibitors, depression INTRODUCTION and night terrors (Ohayon et al., 1999; Yeh et al., 2009).
    [Show full text]
  • Somnology-Jr-Book.Pdf
    1 To Grace Zamudio and Zoe Lee-Chiong. 2 Preface Carpe noctem. Teofilo Lee-Chiong MD Professor of Medicine Division of Sleep Medicine National Jewish Health Denver, Colorado University of Colorado Denver School of Medicine Denver, Colorado Chief Medical Liaison Philips Respironics Murrysville, Pennsylvania 3 Abbreviations AHI Apnea-hypopnea index BPAP Bi-level positive airway pressure CPAP Continuous positive airway pressure CSA Central sleep apnea ECG Electrocardiography EEG Electroencephalography EMG Electromyography EOG Electro-oculography FEV1 Forced expiratory volume in 1 second GABA Gamma-aminobutyric acid N1 NREM stage 1 sleep N2 NREM stage 2 sleep N3 NREM stages 3 (and 4) sleep NREM Non-rapid eye movement O2 Oxygen OSA Obstructive sleep apnea PaCO2 Partial pressure of arterial carbon dioxide PaO2 Partial pressure of arterial oxygen REM Rapid eye movement sleep SaO2 Oxygen saturation SOREMP Sleep onset REM period 4 Table of contents Introduction 15 Neurobiology of sleep 16 Neural systems generating wakefulness 16 Neural systems generating NREM sleep 16 Neural systems generating REM sleep 16 Main neurotransmitters 17 Acetylcholine 17 Adenosine 17 Dopamine 17 Gamma-aminobutyric acid 17 Glutamate 17 Glycine 17 Histamine 18 Hypocretin 18 Melatonin 18 Norepinephrine 18 Serotonin 18 Physiology during sleep 19 Autonomic nervous system 19 Respiratory system 19 Respiratory patterns 19 Cardiovascular system 19 Gastrointestinal system 20 Renal and genito-urinary systems 20 Endocrine system 20 Growth hormone 20 Thyroid stimulating hormone
    [Show full text]
  • Sleep Disorders As Outlined by Outlined As Disorders Sleep of Classification N the Ribe the Features and Symptoms of Each Disorder
    CHAPTER © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION 2NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FORSleep SALE OR DISTRIBUTION Disorders NOT FOR SALE OR DISTRIBUTION © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION © Agsandrew/Shutterstock © Jones & Bartlett Learning, LLC © Jones & Bartlett Learning, LLC NOT FOR SALE OR DISTRIBUTION NOT FOR SALE OR DISTRIBUTION CHAPTER OUTLINE EEG arousal alveolar hypoventilation paradoxical breathing idiopathic central alveolar History of Sleep Disorders© Jones & Bartlett Learning, LLCmicrognathia © Joneshypoventilation & Bartlett Learning, LLC Classification of Sleep DisordersNOT FOR SALE OR DISTRIBUTIONretrognathia NOTsnoring FOR SALE OR DISTRIBUTION Insomnia apnea–hypopnea primary snoring Sleep-Related Breathing Disorders index (AHI) sleep-related groaning Central Disorders of Hypersomnolence respiratory disturbance catathrenia Circadian Rhythm Sleep–Wake Disorders index (RDI) CPAP therapy Parasomnias respiratory effort–related positional therapy Sleep-Related© Jones Movement & Bartlett Disorders Learning, LLC arousal (RERA)© Jones & Bartletttonsillectomy Learning, LLC OtherNOT Sleep FOR Disorders SALE OR DISTRIBUTION upper-airwayNOT resistance FOR SALEadenoidectomy OR DISTRIBUTION Chapter Summary syndrome bi-level therapy excessive daytime multiple sleep latency LEARNING OBJECTIVES sleepiness (EDS) test (MSLT) sudden infant
    [Show full text]
  • Periodic Limb Movement Disorder: Characteristics
    SLEEP SCIENCE : SLEEP , SLEEPINESS , AND SLEEPLESSNESS Kenneth Lichstein, Ph.D. Professor Emeritus Department of Psychology The University of Alabama sleeplessness II a lot can go wrong topics (among 70 sleep disorders) sleep apnea narcolepsy restless legs periodic limb movements disorders we won’t talk about exploding head syndrome sexsomnia sleep-related epilepsy catathrenia if left untreated, sleep apnea is a slow moving terminal illness Pickwickian syndrome (now called obesity-hypoventilation syndrome) obesity, daytime labored breathing, daytime sleepiness ̶ Burwell et al., 1956 10 years later sleep apnea “Nocturnal polygraphic registrations disclosed respiratory pauses…” ̶ Gastaut et al., 1966 invisible sleep apnea science advances by two processes ❑ steady, incremental, systematic research ❑ abrupt, accidental discovery o Between 1956 and 1966, 10s of thousands of PSGs had been performed world wide and no one noticed some people had quit breathing. o Bed partners were not complaining that their partner had quit breathing. when you don’t know what you are looking for, you don’t see the obvious benign snoring and sleep apnea moderate and severe snoring sleep apnea benign snoring I snoring without breath cessation ▪ occurs in 10-15% of population ▪ sleeping on back increases likelihood of snoring ▪ snorer usually has no knowledge of condition ▪ more troublesome to bed partner ▪ at 5-year follow-up, benign snoring (without weight gain) is not a risk factor for sleep apnea physiology ▪ partial airway obstruction ▪ on continuum
    [Show full text]
  • The Effortless Sleep Method: Cure for Insomnia
    Sleeping Pills: An Introduction 1 1 Sleeping Pills: An Introduction What Are Sleeping Pills? Most sleeping pills are “sedative hypnotics.” That’s a specific class of drugs used to induce and/or maintain sleep. Sedative hypnotics include benzodiazepines, barbiturates, and various hypnotics. SLEEPING PILL ABUSE: ITS SIGNS AND SYMPTOMS A number of people underestimate the powerful grip sleeping pills like Ambien or Sonata can have over someone’s life and the dangers of abusing these drugs. 2 The Effortless Sleep Method: Cure for Insomnia... Many people abusing sleeping pills experience memory and concentration problems. Some of the signs of sleeping pill abuse include: • Slurred speech • Uncoordinated movements • Unsteady gait • Inability to focus • Impaired memory • Unusual euphoria. SLEEPING PILLS: ITS MAIN DANGERS Both the immediate and long-term dangers of sleeping pill abuse are enough for most people to exercise caution when using them. However, many people aren’t aware of the dangers of these medications. The dangerous effects of sleep medications range from seizures to depressed breathing. Some people also experience allergic reactions from sleeping pills that can cause difficulty breathing, chest pain, nausea and swelling. Though rare, people who use sleeping pills may even develop parasomnias. Parasomnias are defined as sleep disorders that include behaviors like sleep-walking, sleep-eating, sleep-sex, sleep- driving and other potentially dangerous sleep-related activities. The immediate dangers of sleeping pills range from minor fatigue to coma. Some of these side effects can even lead to deadly overdoses, casting light on the true dangers of sleeping pills. Common symptoms of sleeping pill abuse are: • Dizziness • Dry mouth • Difficulty with coordination • Daytime drowsiness • Memory loss • Unusual dreams • Itching and swelling Sleeping Pills: An Introduction 3 • Lightheadedness • Depressed breathing rate.
    [Show full text]
  • Nocturnal Groaning (Catathrenia) and Epilepsy
    Clinical commentary with video sequences Epileptic Disord 2010; 12 (2): 136-7 Nocturnal groaning (catathrenia) and epilepsy Jan Zinke, Sven Rupprecht, Matthias Schwab, Georg Hagemann Hans Berger Clinic for Neurology, University Hospital Jena, Germany Received March 2, 2010; Accepted April 29, 2010 ABSTRACT – We report the case of a patient with idiopathic generalized epilepsy who ten years after the onset of his epilepsy also developed recurring nocturnal paroxysmal episodes reminiscent of his seizure semiology. Video monitoring and polysomnography revealed episodes of nocturnal groaning. Escalation of antiepileptic treatment was avoided. [Published with video sequences] Key words: differential diagnosis, epilepsy, parasomnia, nocturnal groaning A 22-year-old male suffering from revealed REM-associated episodes seizures was treated with a daily dose of nocturnal groaning without any of 1,500 mg valproate. The seizures further abnormalities (figure 1; see started at the age of 11 years and video sequence). initially were characterized by staring, Nocturnal groaning, or catathrenia, is a hand movements, and impaired rare condition classified as parasomnia consciousness which occurred once (AASM, 2005; Vetrugno et al.,2001) a week during daytime. Additionally, which does not usually require the family reported nocturnal episodes treatment. Therefore, no change of with groaning, more violent jerking of treatment was necessary for this patient. arms and legs, loss of consciousness, Catathrenia has not previously been and enuresis which were considered to reported to be associated with epi- be generalised seizures. Repeated lepsy and it is unknown whether interictal EEGs showed only general- there is any relationship between ised slowing without epileptiform these entities. Therefore, for the time activity or focal abnormalities.
    [Show full text]
  • Indeling Der Slaap
    Classification of sleep disorders Prof. Dr. J. Verbraecken Multidisciplinary Sleep Disorders Centre Antwerp University Hospital University of Antwerp Prevalence Sleep disorders occur in 10% of the population impacting daily live. Most frequent: Insomnia (use of hypnotics !), Sleep related breathing disorders, Restless legs syndrome Classification sleep disorders The old classification systems (1979, 1990, 1997): according to cardinal symptom Insomnia: poor sleep Hypersomnia: too much sleep and/or EDS Parasomnia: abnormal behaviour during sleep International Classification of Sleep Disorders (2005; 2014): according to pathophysiology DSM-V (Diagnostic and Statistical Manual of Mental Disorders) ICD-10 (International Classification of Diseases - WHO) ICSD 3 (AASM): 7 categories 1. Insomnia 2. Sleep Related Breathing Disorders 3. Central Disorders of Hypersomnolence 4. Circadian Rhythm Sleep-Wake Disorders 5. Parasomnias 6. Sleep Related Movement Disorders 7. Other Sleep Disorder Appendix: Sleep Related Medical and Neurological Disorders ICSD 3 (AASM): 7 categories 1. Insomnia 10% 2. Sleep Related Breathing Disorders 3-7% or ↑ 3. Central Disorders of Hypersomnolence 0,02- 0,18% 4. Circadian Sleep-Wake Rhythm Disorders 7-16% 5. Parasomnias (children/adults) 3-17% 6. Sleep Related Movement Disorders 5-10% 7. Other Sleep Disorders Appendix: Sleep Related Medical and Neurological Disorders Insomnia Subjective: Patients suffer from poor sleep Different dimensions: Problem of initiating sleep Problem of maintaining sleep Problem of awakening too
    [Show full text]
  • Role of Inflammation in the Cardiometabolic Co-Morbidities of Sleep Apnoea
    bs_bs_banner Sleep and Biological Rhythms 2015; 13 (Suppl. 1): 1–98 doi:10.1111/sbr.12132 Abstracts (UAMs) have a variety of different discharge patterns. These patterns 001 are found in all UAMs, although the distribution of different patterns ROLE OF INFLAMMATION IN THE differs from one muscle to another. UAM motor units may be divided CARDIOMETABOLIC CO-MORBIDITIES into two classes, the “Inspiratory System” which consists of inspiratory modulated motor units and the “tonic system” consisting of tonic and OF SLEEP APNOEA expiratory modulated motor units. The inspiratory system motor units WALTER MCNICHOLAS1,2 1 2 are recruited under conditions of elevated respiratory drive, such as at University College Dublin, Dublin, Ireland, UCD Conway Institute, arousal from sleep and during hypercapnia, their activity being coor- Dublin, Ireland dinated by a central drive mediated by the respiratory pattern gen- erator, referred to as common drive. Common drive to inspiratory Obstructive sleep apnoea syndrome (OSA) is strongly associated with motor units is pervasive subsuming inspiratory motor units both cardiovascular morbidity and mortality and there is increasing evi- within and between UAMs. This system is the main mechanism for dence for a link between OSA and metabolic dysfunction, in particular the defence of airway patency in the face of closing forces. The tonic insulin resistance and metabolic syndrome. The particular form of system, which consists of almost 50% of motor units in UAMs, intermittent hypoxia (IH) observed in OSA, with repetitive short responds only weakly to airway closure. Further, common drive to cycles of desaturation followed by rapid reoxygenation, plays a major tonic and expiratory modulated motor units within a muscle is less role in the development of cardiovascular co-morbidities.
    [Show full text]
  • Sleep-Physiology.Pdf
    http://www.nap.edu/catalog/11617.html We ship printed books within 1 business day; personal PDFs are available immediately. Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem Harvey R. Colten and Bruce M. Altevogt, Editors, Committee on Sleep Medicine and Research ISBN: 0-309-65727-X, 424 pages, 6 x 9, (2006) This PDF is available from the National Academies Press at: http://www.nap.edu/catalog/11617.html Visit the National Academies Press online, the authoritative source for all books from the National Academy of Sciences, the National Academy of Engineering, the Institute of Medicine, and the National Research Council: • Download hundreds of free books in PDF • Read thousands of books online for free • Explore our innovative research tools – try the “Research Dashboard” now! • Sign up to be notified when new books are published • Purchase printed books and selected PDF files Thank you for downloading this PDF. If you have comments, questions or just want more information about the books published by the National Academies Press, you may contact our customer service department toll- free at 888-624-8373, visit us online, or send an email to [email protected]. This book plus thousands more are available at http://www.nap.edu. Copyright © National Academy of Sciences. All rights reserved. Unless otherwise indicated, all materials in this PDF File are copyrighted by the National Academy of Sciences. Distribution, posting, or copying is strictly prohibited without written permission of the National Academies Press. Request reprint permission for this book. Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem http://www.nap.edu/catalog/11617.html SLEEP DISORDERS AND SLEEP DEPRIVATION AN UNMET PUBLIC HEALTH PROBLEM Committee on Sleep Medicine and Research Board on Health Sciences Policy Harvey R.
    [Show full text]
  • A Practical Guide to the Therapy of Narcolepsy and Hypersomnia Syndromes
    Neurotherapeutics DOI 10.1007/s13311-012-0150-9 A Practical Guide to the Therapy of Narcolepsy and Hypersomnia Syndromes Emmanuel J. M. Mignot # The Author(s) 2012. This article is published with open access at Springerlink.com Summary Narcolepsy and other syndromes associated possibility of tolerance and the development of stimulant with excessive daytime sleepiness can be challenging to addiction. Kleine-Levin Syndrome is usually best left untreat- treat. New classifications now distinguish narcolepsy/hypo- ed, although lithium can be considered in severe cases with cretin deficiency (also called type 1 narcolepsy), a lifelong frequent episodes. Guidelines are provided based on the liter- disorder with well-established diagnostic procedures and ature and personal experience of the author. etiology, from other syndromes with hypersomnolence of unknown causes. Klein-Levin Syndrome, a periodic hyper- Keywords Narcolepsy . Hypocretin . Orexin . Sodium somnia associated with cognitive and behavioral abnormal- oxybate . Modafinil . Venlafaxine ities, is also considered a separate entity with separate therapeutic protocols. Non hypocretin-related hypersomnia syndromes are diagnoses of exclusion. These diagnoses are Introduction only made after eliminating sleep deprivation, sleep apnea, disturbed nocturnal sleep, and psychiatric comorbidities as According to the Diagnostic and Statistical Manual of Men- the primary cause of daytime sleepiness. The treatment of tal Disorders, 5th edition (DSM-5) currently being final- narcolepsy/hypocretin deficiency is well-codified, and ized, syndromes with primary hypersomnolence can be involves pharmacotherapies using sodium oxybate, stimu- practically divided into 3 groups: 1) narcolepsy caused by lants, and/or antidepressants, plus behavioral modifications. hypocretin (orexin) deficiency, a disorder associated with These therapies are almost always needed, and the risk-to- Human Leukocyte Antigen (HLA) marker DQB1*06:02 benefit ratio is clear, notably in children.
    [Show full text]